Harvard Catalyst Profiles

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Laura M Holsen, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK104772 (HOLSEN, LAURA MCGRATH) Dec 23, 2015 - Nov 30, 2021
    Ghrelin Modulation of Mesolimbic Reward Signaling in Stress-induced Hyperphagia
    Role: Principal Investigator
  2. K01MH091222 (HOLSEN, LAURA MCGRATH) Jul 1, 2011 - Nov 30, 2015
    Neural mechanisms underlying abnormal food reward processing in depressed women
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wronski ML, Plessow F, Kerem L, Asanza E, O'Donoghue ML, Stanford FC, Bredella MA, Torriani M, Soukas AA, Kheterpal A, Eddy KT, Holmes TM, Deckersbach T, Vangel M, Holsen LM, Lawson EA. A randomized, double-blind, placebo-controlled clinical trial of 8-week intranasal oxytocin administration in adults with obesity: Rationale, study design, and methods. Contemp Clin Trials. 2022 Nov; 122:106909. PMID: 36087842.
    Citations:    Fields:    Translation:HumansAnimals
  2. Piccolo M, Belleau EL, Holsen LM, Trivedi MH, Parsey RV, McGrath PJ, Weissman MM, Pizzagalli DA, Javaras KN. Alterations in resting-state functional activity and connectivity for major depressive disorder appetite and weight disturbance phenotypes. Psychol Med. 2022 Jun 07; 1-11. PMID: 35670301.
    Citations:    Fields:    
  3. Breithaupt L, Kahn DL, Slattery M, Plessow F, Mancuso C, Izquierdo A, Dreier MJ, Becker K, Franko DL, Thomas JJ, Holsen L, Lawson EA, Misra M, Eddy KT. Eighteen-month Course and Outcome of Adolescent Restrictive Eating Disorders: Persistence, Crossover, and Recovery. J Clin Child Adolesc Psychol. 2022 Sep-Oct; 51(5):715-725. PMID: 35476589; PMCID: PMC9444807.
    Citations:    Fields:    
  4. Busler JN, Coello E, Liao H, Taylor J, Zhao W, Holsen LM, Lin AP, Mahon PB. Perceived Stress, Cortical GABA, and Functional Connectivity Correlates: A Hypothesis-Generating Preliminary Study. Front Psychiatry. 2022; 13:802449. PMID: 35350427; PMCID: PMC8957825.
  5. Low AYT, Goldstein N, Gaunt JR, Huang KP, Zainolabidin N, Yip AKK, Carty JRE, Choi JY, Miller AM, Ho HST, Lenherr C, Baltar N, Azim E, Sessions OM, Ch'ng TH, Bruce AS, Martin LE, Halko MA, Brady RO, Holsen LM, Alhadeff AL, Chen AI, Betley JN. Reverse-translational identification of a cerebellar satiation network. Nature. 2021 12; 600(7888):269-273. PMID: 34789878; PMCID: PMC8665128.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  6. Chang RS, Cerit H, Hye T, Durham EL, Aizley H, Boukezzi S, Haimovici F, Goldstein JM, Dillon DG, Pizzagalli DA, Holsen LM. Stress-induced alterations in HPA-axis reactivity and mesolimbic reward activation in individuals with emotional eating. Appetite. 2022 01 01; 168:105707. PMID: 34562531; PMCID: PMC8671188.
    Citations: 1     Fields:    Translation:Humans
  7. Dreier MJ, Van De Water AL, Kahn DL, Becker KR, Eddy KT, Thomas JJ, Holsen LM, Lawson EA, Misra M, Lyall AE, Breithaupt L. Meta-analysis of structural MRI studies in anorexia nervosa and the role of recovery: a systematic review protocol. Syst Rev. 2021 09 13; 10(1):247. PMID: 34517926; PMCID: PMC8438886.
    Citations:    Fields:    Translation:Humans
  8. Holsen LM, Hoge WS, Lennerz BS, Cerit H, Hye T, Moondra P, Goldstein JM, Ebbeling CB, Ludwig DS. Diets Varying in Carbohydrate Content Differentially Alter Brain Activity in Homeostatic and Reward Regions in Adults. J Nutr. 2021 08 07; 151(8):2465-2476. PMID: 33852013; PMCID: PMC8349124.
    Citations: 3     Fields:    Translation:Humans
  9. Ironside M, Moser AD, Holsen LM, Zuo CS, Du F, Perlo S, Richards CE, Duda JM, Chen X, Nickerson LD, Null KE, Nascimento N, Crowley DJ, Misra M, Goldstein JM, Pizzagalli DA. Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation. Neuropsychopharmacology. 2021 11; 46(12):2188-2196. PMID: 34363015; PMCID: PMC8505659.
    Citations:    Fields:    Translation:Humans
  10. Goldstein JM, Cohen JE, Mareckova K, Holsen L, Whitfield-Gabrieli S, Gilman SE, Buka SL, Hornig M. Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). PMID: 33876747.
    Citations: 9     Fields:    Translation:Humans
  11. Kerem L, Van De Water AL, Kuhnle MC, Harshman S, Hauser K, Eddy KT, Becker KR, Misra M, Micali N, Thomas JJ, Holsen L, Lawson EA. Neurobiology of Avoidant/Restrictive Food Intake Disorder in Youth with Overweight/Obesity Versus Healthy Weight. J Clin Child Adolesc Psychol. 2022 Sep-Oct; 51(5):701-714. PMID: 33769133; PMCID: PMC8464625.
    Citations:    Fields:    
  12. Holsen LM, Huang G, Cherkerzian S, Aroner S, Loucks EB, Buka S, Handa RJ, Goldstein JM. Sex Differences in Hemoglobin A1c Levels Related to the Comorbidity of Obesity and Depression. J Womens Health (Larchmt). 2021 09; 30(9):1303-1312. PMID: 33534642; PMCID: PMC8558065.
    Citations:    Fields:    Translation:Humans
  13. Kerem L, Holsen L, Fazeli P, Bredella MA, Mancuso C, Resulaj M, Holmes TM, Klibanski A, Lawson EA. Modulation of neural fMRI responses to visual food cues by overeating and fasting interventions: A preliminary study. Physiol Rep. 2021 01; 8(24):e14639. PMID: 33369272.
    Citations: 1     Fields:    Translation:Humans
  14. Duda JM, Moser AD, Zuo CS, Du F, Chen X, Perlo S, Richards CE, Nascimento N, Ironside M, Crowley DJ, Holsen LM, Misra M, Hudson JI, Goldstein JM, Pizzagalli DA. Repeatability and reliability of GABA measurements with magnetic resonance spectroscopy in healthy young adults. Magn Reson Med. 2021 05; 85(5):2359-2369. PMID: 33216412; PMCID: PMC7902337.
    Citations: 4     Fields:    Translation:Humans
  15. Breithaupt L, Chunga-Iturry N, Lyall AE, Cetin-Karayumak S, Becker KR, Thomas JJ, Slattery M, Makris N, Plessow F, Pasternak O, Holsen LM, Kubicki M, Misra M, Lawson EA, Eddy KT. Developmental stage-dependent relationships between ghrelin levels and hippocampal white matter connections in low-weight anorexia nervosa and atypical anorexia nervosa. Psychoneuroendocrinology. 2020 09; 119:104722. PMID: 32512249.
    Citations: 3     Fields:    Translation:Humans
  16. Garcia RG, Mareckova K, Holsen LM, Cohen JE, Whitfield-Gabrieli S, Napadow V, Barbieri R, Goldstein JM. Impact of sex and depressed mood on the central regulation of cardiac autonomic function. Neuropsychopharmacology. 2020 07; 45(8):1280-1288. PMID: 32152473; PMCID: PMC7298013.
    Citations: 5     Fields:    Translation:Humans
  17. Kerem L, Hadjikhani N, Holsen L, Lawson EA, Plessow F. Oxytocin reduces the functional connectivity between brain regions involved in eating behavior in men with overweight and obesity. Int J Obes (Lond). 2020 05; 44(5):980-989. PMID: 31740723.
    Citations: 5     Fields:    Translation:Humans
  18. Cerit H, Davidson P, Hye T, Moondra P, Haimovici F, Sogg S, Shikora S, Goldstein JM, Evins AE, Whitfield-Gabrieli S, Stoeckel LE, Holsen LM. Resting-State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy. Obesity (Silver Spring). 2019 11; 27(11):1846-1855. PMID: 31689011.
    Citations: 6     Fields:    Translation:Humans
  19. Cerit H, Christensen K, Moondra P, Klibanski A, Goldstein JM, Holsen LM. Divergent associations between ghrelin and neural responsivity to palatable food in hyperphagic and hypophagic depression. J Affect Disord. 2019 01 01; 242:29-38. PMID: 30170236.
    Citations: 4     Fields:    Translation:Humans
  20. Plessow F, Marengi DA, Perry SK, Felicione JM, Franklin R, Holmes TM, Holsen LM, Makris N, Deckersbach T, Lawson EA. Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men. Neuropsychopharmacology. 2018 02; 43(3):638-645. PMID: 28930284.
    Citations: 19     Fields:    Translation:Humans
  21. Holsen LM, Davidson P, Cerit H, Hye T, Moondra P, Haimovici F, Sogg S, Shikora S, Goldstein JM, Evins AE, Stoeckel LE. Neural predictors of 12-month weight loss outcomes following bariatric surgery. Int J Obes (Lond). 2018 04; 42(4):785-793. PMID: 28894291.
    Citations: 19     Fields:    Translation:Humans
  22. Holsen LM, Jackson B. Reward Capacity Predicts Leptin Dynamics During Laboratory-Controlled Eating in Women as a Function of Body Mass Index. Obesity (Silver Spring). 2017 09; 25(9):1564-1568. PMID: 28722317.
    Citations:    Fields:    Translation:Humans
  23. Mareckova K, Holsen L, Admon R, Whitfield-Gabrieli S, Seidman LJ, Buka SL, Klibanski A, Goldstein JM. Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex. J Affect Disord. 2017 11; 222:88-97. PMID: 28688266; PMCID: PMC5560420.
    Citations: 10     Fields:    Translation:Humans
  24. Goldstein JM, Holsen L, Huang G, Hammond BD, James-Todd T, Cherkerzian S, Hale TM, Handa RJ. Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome. Dialogues Clin Neurosci. 2016 12; 18(4):425-436. PMID: 28179814; PMCID: PMC5286728.
    Citations: 19     Fields:    Translation:Humans
  25. Mareckova K, Holsen LM, Admon R, Makris N, Seidman L, Buka S, Whitfield-Gabrieli S, Goldstein JM. Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. Hum Brain Mapp. 2016 11; 37(11):3733-3744. PMID: 27246897.
    Citations: 16     Fields:    Translation:Humans
  26. Mason SM, Bryn Austin S, Bakalar JL, Boynton-Jarrett R, Field AE, Gooding HC, Holsen LM, Jackson B, Neumark-Sztainer D, Sanchez M, Sogg S, Tanofsky-Kraff M, Rich-Edwards JW. Child Maltreatment's Heavy Toll: The Need for Trauma-Informed Obesity Prevention. Am J Prev Med. 2016 May; 50(5):646-649. PMID: 26689978.
    Citations: 14     Fields:    Translation:Humans
  27. Lawson EA, Holsen LM, Santin M, DeSanti R, Meenaghan E, Eddy KT, Herzog DB, Goldstein JM, Klibanski A. Correction: Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa. J Clin Psychiatry. 2015 05; 76(5):666. PMID: 26035205.
    Citations:    Fields:    
  28. Holsen LM, Goldstein JM. Valuation and cognitive circuitry in anorexia nervosa: disentangling appetite from the effort to obtain a reward. Biol Psychiatry. 2015 Apr 01; 77(7):604-6. PMID: 25766686.
    Citations: 1     Fields:    Translation:Humans
  29. Goldstein JM, Lancaster K, Longenecker JM, Abbs B, Holsen LM, Cherkerzian S, Whitfield-Gabrieli S, Makris N, Tsuang MT, Buka SL, Seidman LJ, Klibanski A. Sex differences, hormones, and fMRI stress response circuitry deficits in psychoses. Psychiatry Res. 2015 Jun 30; 232(3):226-36. PMID: 25914141; PMCID: PMC4439265.
    Citations: 12     Fields:    Translation:Humans
  30. Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH. Ghrelin. Mol Metab. 2015 Jun; 4(6):437-60. PMID: 26042199.
    Citations: 319     Fields:    
  31. Admon R, Holsen LM, Aizley H, Remington A, Whitfield-Gabrieli S, Goldstein JM, Pizzagalli DA. Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression. Biol Psychiatry. 2015 Jul 01; 78(1):67-76. PMID: 25483401; PMCID: PMC4383718.
    Citations: 37     Fields:    Translation:Humans
  32. Goldstein JM, Holsen L, Handa R, Tobet S. Fetal hormonal programming of sex differences in depression: linking women's mental health with sex differences in the brain across the lifespan. Front Neurosci. 2014; 8:247. PMID: 25249929.
    Citations: 24     
  33. Jacobs EG, Holsen LM, Lancaster K, Makris N, Whitfield-Gabrieli S, Remington A, Weiss B, Buka S, Klibanski A, Goldstein JM. 17ß-estradiol differentially regulates stress circuitry activity in healthy and depressed women. Neuropsychopharmacology. 2015 Feb; 40(3):566-76. PMID: 25113601.
    Citations: 29     Fields:    Translation:Humans
  34. Holsen LM, Lawson EA, Christensen K, Klibanski A, Goldstein JM. Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa. Psychiatry Res. 2014 Aug 30; 223(2):94-103. PMID: 24862390.
    Citations: 27     Fields:    Translation:HumansCells
  35. Lawson EA, Holsen LM, Desanti R, Santin M, Meenaghan E, Herzog DB, Goldstein JM, Klibanski A. Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa. Eur J Endocrinol. 2013 Nov; 169(5):639-47. PMID: 23946275.
    Citations: 20     Fields:    Translation:Humans
  36. Holsen LM, Lancaster K, Klibanski A, Whitfield-Gabrieli S, Cherkerzian S, Buka S, Goldstein JM. HPA-axis hormone modulation of stress response circuitry activity in women with remitted major depression. Neuroscience. 2013 Oct 10; 250:733-42. PMID: 23891965.
    Citations: 43     Fields:    Translation:Humans
  37. Lennerz BS, Alsop DC, Holsen LM, Stern E, Rojas R, Ebbeling CB, Goldstein JM, Ludwig DS. Effects of dietary glycemic index on brain regions related to reward and craving in men. Am J Clin Nutr. 2013 Sep; 98(3):641-7. PMID: 23803881; PMCID: PMC3743729.
    Citations: 38     Fields:    Translation:HumansPHPublic Health
  38. Lawson EA, Holsen LM, Santin M, DeSanti R, Meenaghan E, Eddy KT, Herzog DB, Goldstein JM, Klibanski A. Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa. J Clin Psychiatry. 2013 May; 74(5):e451-7. PMID: 23759466.
    Citations: 24     Fields:    Translation:Humans
  39. Holsen LM, Lawson EA, Blum J, Ko E, Makris N, Fazeli PK, Klibanski A, Goldstein JM. Food motivation circuitry hypoactivation related to hedonic and nonhedonic aspects of hunger and satiety in women with active anorexia nervosa and weight-restored women with anorexia nervosa. J Psychiatry Neurosci. 2012 Sep; 37(5):322-32. PMID: 22498079.
    Citations: 60     Fields:    Translation:Humans
  40. Lawson EA, Holsen LM, Santin M, Meenaghan E, Eddy KT, Becker AE, Herzog DB, Goldstein JM, Klibanski A. Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa. J Clin Endocrinol Metab. 2012 Oct; 97(10):E1898-908. PMID: 22872688; PMCID: PMC3674290.
    Citations: 45     Fields:    Translation:Humans
  41. Honea RA, Holsen LM, Lepping RJ, Perea R, Butler MG, Brooks WM, Savage CR. The neuroanatomy of genetic subtype differences in Prader-Willi syndrome. Am J Med Genet B Neuropsychiatr Genet. 2012 Mar; 159B(2):243-53. PMID: 22241551.
    Citations: 17     Fields:    Translation:Humans
  42. Holsen LM, Lee JH, Spaeth SB, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Sloan RP, Goldstein JM. Brain hypoactivation, autonomic nervous system dysregulation, and gonadal hormones in depression: a preliminary study. Neurosci Lett. 2012 Apr 11; 514(1):57-61. PMID: 22395084.
    Citations: 21     Fields:    Translation:Humans
  43. Holsen LM, Savage CR, Martin LE, Bruce AS, Lepping RJ, Ko E, Brooks WM, Butler MG, Zarcone JR, Goldstein JM. Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs simple obesity. Int J Obes (Lond). 2012 May; 36(5):638-47. PMID: 22024642.
    Citations: 32     Fields:    Translation:Humans
  44. Bruce JM, Hancock L, Bruce A, Lepping RJ, Martin L, Lundgren JD, Malley S, Holsen LM, Savage CR. Changes in brain activation to food pictures after adjustable gastric banding. Surg Obes Relat Dis. 2012 Sep-Oct; 8(5):602-8. PMID: 21996599.
    Citations: 33     Fields:    Translation:Humans
  45. Holsen LM, Spaeth SB, Lee JH, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Goldstein JM. Stress response circuitry hypoactivation related to hormonal dysfunction in women with major depression. J Affect Disord. 2011 Jun; 131(1-3):379-87. PMID: 21183223.
    Citations: 42     Fields:    Translation:Humans
  46. Bruce AS, Holsen LM, Chambers RJ, Martin LE, Brooks WM, Zarcone JR, Butler MG, Savage CR. Obese children show hyperactivation to food pictures in brain networks linked to motivation, reward and cognitive control. Int J Obes (Lond). 2010 Oct; 34(10):1494-500. PMID: 20440296.
    Citations: 112     Fields:    Translation:Humans
  47. Martin LE, Holsen LM, Chambers RJ, Bruce AS, Brooks WM, Zarcone JR, Butler MG, Savage CR. Neural mechanisms associated with food motivation in obese and healthy weight adults. Obesity (Silver Spring). 2010 Feb; 18(2):254-60. PMID: 19629052.
    Citations: 128     Fields:    Translation:Humans
  48. Holsen LM, Zarcone JR, Chambers R, Butler MG, Bittel DC, Brooks WM, Thompson TI, Savage CR. Genetic subtype differences in neural circuitry of food motivation in Prader-Willi syndrome. Int J Obes (Lond). 2009 Feb; 33(2):273-83. PMID: 19048015.
    Citations: 21     Fields:    Translation:HumansCells
  49. Holsen LM, Zarcone JR, Brooks WM, Butler MG, Thompson TI, Ahluwalia JS, Nollen NL, Savage CR. Neural mechanisms underlying hyperphagia in Prader-Willi syndrome. Obesity (Silver Spring). 2006 Jun; 14(6):1028-37. PMID: 16861608.
    Citations: 59     Fields:    Translation:Humans
  50. Young J, Zarcone J, Holsen L, Anderson MC, Hall S, Richman D, Butler MG, Thompson T. A measure of food seeking in individuals with Prader-Willi syndrome. J Intellect Disabil Res. 2006 Jan; 50(Pt 1):18-24. PMID: 16316427; PMCID: PMC1535345.
    Citations: 2     Fields:    Translation:Humans
  51. Holsen LM, Zarcone JR, Thompson TI, Brooks WM, Anderson MF, Ahluwalia JS, Nollen NL, Savage CR. Neural mechanisms underlying food motivation in children and adolescents. Neuroimage. 2005 Sep; 27(3):669-76. PMID: 15993629.
    Citations: 60     Fields:    Translation:HumansCTClinical Trials
  52. Holsen L, Thompson T. Compulsive behavior and eye blink in Prader-Willi syndrome: neurochemical implications. Am J Ment Retard. 2004 May; 109(3):197-207. PMID: 15072522.
    Citations: 1     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.