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profileLaura M Holsen, PH.D.

TitleAssistant Professor of Psychiatry
InstitutionBrigham and Women's Hospital
DepartmentPsychiatry
AddressBrigham and Women's Hospital
B C -3, D W H
1620 Tremont St
Boston MA 02120
Phone617/525-8772
Fax617/525-7900
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Collapse Research 
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DK104772     (HOLSEN, LAURA MCGRATH)Dec 23, 2015 - Nov 30, 2020
NIH/NIDDK
Ghrelin Modulation of Mesolimbic Reward Signaling in Stress-induced Hyperphagia
Role: Principal Investigator

K01MH091222     (HOLSEN, LAURA MCGRATH)Jul 1, 2011 - Apr 30, 2015
NIH/NIMH
Neural mechanisms underlying abnormal food reward processing in depressed women
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mareckova K, Holsen L, Admon R, Whitfield-Gabrieli S, Seidman LJ, Buka SL, Klibanski A, Goldstein JM. Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex. J Affect Disord. 2017 Jun 28; 222:88-97. PMID: 28688266.
    View in: PubMed
  2. Goldstein JM, Holsen L, Huang G, Hammond BD, James-Todd T, Cherkerzian S, Hale TM, Handa RJ. Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome. Dialogues Clin Neurosci. 2016 Dec; 18(4):425-436. PMID: 28179814.
    View in: PubMed
  3. Mareckova K, Holsen LM, Admon R, Makris N, Seidman L, Buka S, Whitfield-Gabrieli S, Goldstein JM. Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses. Hum Brain Mapp. 2016 Nov; 37(11):3733-3744. PMID: 27246897.
    View in: PubMed
  4. Mason SM, Bryn Austin S, Bakalar JL, Boynton-Jarrett R, Field AE, Gooding HC, Holsen LM, Jackson B, Neumark-Sztainer D, Sanchez M, Sogg S, Tanofsky-Kraff M, Rich-Edwards JW. Child Maltreatment's Heavy Toll: The Need for Trauma-Informed Obesity Prevention. Am J Prev Med. 2016 May; 50(5):646-9. PMID: 26689978; PMCID: PMC4905569.
  5. Holsen LM, Goldstein JM. Valuation and cognitive circuitry in anorexia nervosa: disentangling appetite from the effort to obtain a reward. Biol Psychiatry. 2015 Apr 01; 77(7):604-6. PMID: 25766686.
    View in: PubMed
  6. Goldstein JM, Lancaster K, Longenecker JM, Abbs B, Holsen LM, Cherkerzian S, Whitfield-Gabrieli S, Makris N, Tsuang MT, Buka SL, Seidman LJ, Klibanski A. Sex differences, hormones, and fMRI stress response circuitry deficits in psychoses. Psychiatry Res. 2015 Jun 30; 232(3):226-36. PMID: 25914141; PMCID: PMC4439265.
  7. Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH. Ghrelin. Mol Metab. 2015 Jun; 4(6):437-60. PMID: 26042199; PMCID: PMC4443295.
  8. Admon R, Holsen LM, Aizley H, Remington A, Whitfield-Gabrieli S, Goldstein JM, Pizzagalli DA. Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression. Biol Psychiatry. 2015 Jul 01; 78(1):67-76. PMID: 25483401; PMCID: PMC4383718.
  9. Goldstein JM, Holsen L, Handa R, Tobet S. Fetal hormonal programming of sex differences in depression: linking women's mental health with sex differences in the brain across the lifespan. Front Neurosci. 2014; 8:247. PMID: 25249929; PMCID: PMC4157606.
  10. Jacobs EG, Holsen LM, Lancaster K, Makris N, Whitfield-Gabrieli S, Remington A, Weiss B, Buka S, Klibanski A, Goldstein JM. 17ß-estradiol differentially regulates stress circuitry activity in healthy and depressed women. Neuropsychopharmacology. 2015 Feb; 40(3):566-76. PMID: 25113601; PMCID: PMC4289944.
  11. Holsen LM, Lawson EA, Christensen K, Klibanski A, Goldstein JM. Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa. Psychiatry Res. 2014 Aug 30; 223(2):94-103. PMID: 24862390; PMCID: PMC4090258.
  12. Lawson EA, Holsen LM, Desanti R, Santin M, Meenaghan E, Herzog DB, Goldstein JM, Klibanski A. Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa. Eur J Endocrinol. 2013 Nov; 169(5):639-47. PMID: 23946275; PMCID: PMC3807591.
  13. Holsen LM, Lancaster K, Klibanski A, Whitfield-Gabrieli S, Cherkerzian S, Buka S, Goldstein JM. HPA-axis hormone modulation of stress response circuitry activity in women with remitted major depression. Neuroscience. 2013 Oct 10; 250:733-42. PMID: 23891965; PMCID: PMC3772711.
  14. Lennerz BS, Alsop DC, Holsen LM, Stern E, Rojas R, Ebbeling CB, Goldstein JM, Ludwig DS. Effects of dietary glycemic index on brain regions related to reward and craving in men. Am J Clin Nutr. 2013 Sep; 98(3):641-7. PMID: 23803881; PMCID: PMC3743729.
  15. Lawson EA, Holsen LM, Santin M, DeSanti R, Meenaghan E, Eddy KT, Herzog DB, Goldstein JM, Klibanski A. Postprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa. J Clin Psychiatry. 2013 May; 74(5):e451-7. PMID: 23759466; PMCID: PMC3731039.
  16. Holsen LM, Lawson EA, Blum J, Ko E, Makris N, Fazeli PK, Klibanski A, Goldstein JM. Food motivation circuitry hypoactivation related to hedonic and nonhedonic aspects of hunger and satiety in women with active anorexia nervosa and weight-restored women with anorexia nervosa. J Psychiatry Neurosci. 2012 Sep; 37(5):322-32. PMID: 22498079; PMCID: PMC3447131.
  17. Lawson EA, Holsen LM, Santin M, Meenaghan E, Eddy KT, Becker AE, Herzog DB, Goldstein JM, Klibanski A. Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa. J Clin Endocrinol Metab. 2012 Oct; 97(10):E1898-908. PMID: 22872688; PMCID: PMC3674290.
  18. Honea RA, Holsen LM, Lepping RJ, Perea R, Butler MG, Brooks WM, Savage CR. The neuroanatomy of genetic subtype differences in Prader-Willi syndrome. Am J Med Genet B Neuropsychiatr Genet. 2012 Mar; 159B(2):243-53. PMID: 22241551; PMCID: PMC3296480.
  19. Holsen LM, Lee JH, Spaeth SB, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Sloan RP, Goldstein JM. Brain hypoactivation, autonomic nervous system dysregulation, and gonadal hormones in depression: a preliminary study. Neurosci Lett. 2012 Apr 11; 514(1):57-61. PMID: 22395084; PMCID: PMC3319257.
  20. Holsen LM, Savage CR, Martin LE, Bruce AS, Lepping RJ, Ko E, Brooks WM, Butler MG, Zarcone JR, Goldstein JM. Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs simple obesity. Int J Obes (Lond). 2012 May; 36(5):638-47. PMID: 22024642; PMCID: PMC3270121.
  21. Bruce JM, Hancock L, Bruce A, Lepping RJ, Martin L, Lundgren JD, Malley S, Holsen LM, Savage CR. Changes in brain activation to food pictures after adjustable gastric banding. Surg Obes Relat Dis. 2012 Sep-Oct; 8(5):602-8. PMID: 21996599.
    View in: PubMed
  22. Holsen LM, Spaeth SB, Lee JH, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Goldstein JM. Stress response circuitry hypoactivation related to hormonal dysfunction in women with major depression. J Affect Disord. 2011 Jun; 131(1-3):379-87. PMID: 21183223; PMCID: PMC3073153.
  23. Bruce AS, Holsen LM, Chambers RJ, Martin LE, Brooks WM, Zarcone JR, Butler MG, Savage CR. Obese children show hyperactivation to food pictures in brain networks linked to motivation, reward and cognitive control. Int J Obes (Lond). 2010 Oct; 34(10):1494-500. PMID: 20440296.
    View in: PubMed
  24. Martin LE, Holsen LM, Chambers RJ, Bruce AS, Brooks WM, Zarcone JR, Butler MG, Savage CR. Neural mechanisms associated with food motivation in obese and healthy weight adults. Obesity (Silver Spring). 2010 Feb; 18(2):254-60. PMID: 19629052.
    View in: PubMed
  25. Holsen LM, Zarcone JR, Chambers R, Butler MG, Bittel DC, Brooks WM, Thompson TI, Savage CR. Genetic subtype differences in neural circuitry of food motivation in Prader-Willi syndrome. Int J Obes (Lond). 2009 Feb; 33(2):273-83. PMID: 19048015; PMCID: PMC2643328.
  26. Holsen LM, Zarcone JR, Brooks WM, Butler MG, Thompson TI, Ahluwalia JS, Nollen NL, Savage CR. Neural mechanisms underlying hyperphagia in Prader-Willi syndrome. Obesity (Silver Spring). 2006 Jun; 14(6):1028-37. PMID: 16861608; PMCID: PMC1535344.
  27. Young J, Zarcone J, Holsen L, Anderson MC, Hall S, Richman D, Butler MG, Thompson T. A measure of food seeking in individuals with Prader-Willi syndrome. J Intellect Disabil Res. 2006 Jan; 50(Pt 1):18-24. PMID: 16316427; PMCID: PMC1535345.
  28. Holsen LM, Zarcone JR, Thompson TI, Brooks WM, Anderson MF, Ahluwalia JS, Nollen NL, Savage CR. Neural mechanisms underlying food motivation in children and adolescents. Neuroimage. 2005 Sep; 27(3):669-76. PMID: 15993629; PMCID: PMC1535274.
  29. Holsen L, Thompson T. Compulsive behavior and eye blink in Prader-Willi syndrome: neurochemical implications. Am J Ment Retard. 2004 May; 109(3):197-207. PMID: 15072522.
    View in: PubMed
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