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Richard Leonard Verrier, Ph.D.

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Overview
My research concentrates on the major public health problem of sudden cardiac death, which claims approximately 325,000 lives per year in the United States alone and occurs without prodromes in at least 30% of cases. The main challenges have been to elucidate the complex pathophysiologic factors involved and to develop novel approaches for identifying individuals at risk for this mode of demise.

In an extensive series of studies, my colleagues and I explored the mechanisms responsible for sudden arrhythmic death. Our investigations demonstrated the pivotal role played by sympathetic nerve activity in triggering life-threatening arrhythmias and defined contributions of beta-adrenergic receptors acting primarily on intracellular calcium handling. We also determined that vagus nerve activity opposes the deleterious influence of adrenergic activity by opposition to presynaptic release of norepinephrine and direct antagonism of second messenger effects. I developed an experimental model in canines that emulated the angerlike state and allowed us to demonstrate that intense behavioral arousal profoundly alters cardiac electrical instability and coronary reactivity, which in turn predispose to malignant arrhythmias. My group and I also systematically studied the impact of sleep states on coronary hemodynamic and cardiac electrophysiologic function. The knowledge base generated was published in Science, Circulation, New England Journal of Medicine, and other leading journals. My basic science studies on neural control of heart rhythm received NIH funding for more than 35 years.

My most significant contributions to clinical innovation emerged during my appointment at Harvard Medical School in Beth Israel Deaconess Medical Center’s Division of Cardiovascular Medicine. In collaboration with my junior colleague, Dr. Bruce D. Nearing, a biomedical engineer, I discovered and published in Science in 1991 evidence that a fundamental electrophysiologic phenomenon, “T-wave alternans,” a beat-to-beat fluctuation in the magnitude of this waveform, is capable of stratifying risk for life-threatening arrhythmia. An extensive series of experiments revealed that T-wave alternans is tracks effects of neural factors, myocardial ischemia, and other proarrhythmic influences. Conversely, antiarrhythmic physiologic and pharmacologic interventions reduce the magnitude of alternans. These findings provided essential scientific underpinnings for utilizing alternans as a clinical marker of arrhythmic risk and target for therapeutic interventions. We developed, patented, and implemented methodologies for quantifying alternans that are compatible with routine ambulatory ECG monitoring and exercise stress testing and employed them to demonstrate that this phenomenon is capable of assessing risk for arrhythmic events in >1,600 post-myocardial infarction and heart failure patients based on ambulatory ECGs recordings. Prediction was also demonstrated in >3,500 consecutive patients with preserved left ventricular function who were referred for routine exercise testing. In 2011, I was lead author of a clinical consensus guideline on T-wave alternans by international experts that was published in Journal of the American College of Cardiology.

In summary, my research program focuses on sudden cardiac death, with dual emphasis on elucidation of pathophysiologic mechanisms and translation from bench to bedside. Our patented, FDA-approved diagnostic risk assessment technology is now in use in clinics and hospitals worldwide.

Mentoring
Available: 06/24/13, Expires: 06/30/19

The study will address the important clinical question of how to identify patients who will respond to cardiac resynchronization therapy, which is a state-of-the-art technology to improve cardiac output in patients following heart attack. The student will learn to analyze ambulatory or hospital ECGs for T-Wave Alternans and Spatial Heterogeneity of Depolarization and Repolarization. He or she will work in a group with expertise in cardiovascular medicine, engineering, and statistics, in an office setting with other medical students and will gain expertise in interpretation of the electrocardiogram and noninvasive stratification of risk for ventricular arrhythmia. He/she may submit abstracts of findings for presentation at national scientific sessions of Heart Rhythm Society, American Heart Association, or American College of Cardiology.

Chemical Cardioversion of Atrial Fibrillation by Transatrial Delivery of Antiarrhythmic Agents into the Pericardial Space
Summer, 05/15/00 - 08/18/00
A Novel Approach for Prevention and Treatment of Atrial Fibrillation by Intrapericardial L-Arginine Administration
Summer, 06/18/01 - 08/10/01
Characterization of the Efficacy of Intrapericardially Delivered Autonomic Nerve Blocking Agents in Protection Against Ischemia/reperfusion-induced Arrhythmia in Pigs
Summer, 06/01/02 - 08/31/02

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL063968 (VERRIER, RICHARD L) May 10, 2001 - Mar 31, 2006
    NIH/NHLBI
    ANTIFIBRILLATORY MECHANISMS OF INTRAPERICARDIAL AGENTS
    Role: Principal Investigator
  2. P01ES008129 (GODLESKI, JOHN J) Jun 28, 1997 - Jun 30, 2003
    NIH/NIEHS
    MECHANISMS OF MORBIDITY/MORTALITY DUE TO AIR PARTICLES
    Role: Co-Principal Investigator
  3. R01HL050078 (VERRIER, RICHARD L) May 19, 1994 - Apr 30, 1999
    NIH/NHLBI
    DYNAMIC TRACKING OF CARDIAC ARRHYTHMOGENESIS IN SLEEP
    Role: Principal Investigator
  4. R01HL032905 (VERRIER, RICHARD L) Sep 30, 1985 - Jun 30, 1990
    NIH/NHLBI
    EFFECT OF SLEEP ON MYCARDIAL PERFUSION AND ARRHYTHMIAS
    Role: Principal Investigator
  5. R01HL035138 (VERRIER, RICHARD L) Sep 30, 1985 - Sep 29, 1989
    NIH/NHLBI
    STRESS, NEUROACTIVE PEPTIDES, AND CARDIAC ARRHYTHMIAS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Huikuri HV, Verrier RL, Malik M, Lombardi F, Schmidt G, Zabel M. Our doubts about the usefulness of the Tpeak-Tend interval. Heart Rhythm. 2019 Jan 22. PMID: 30682431.
    Citations:    Fields:    
  2. Malik M, Huikuri HV, Lombardi F, Schmidt G, Verrier RL, Zabel M. Is the Tpeak-Tend interval as a measure of repolarization heterogeneity dead or just seriously wounded? Heart Rhythm. 2019 Jan 17. PMID: 30660561.
    Citations:    Fields:    
  3. de Antonio VZ, Silva AC, Stocco FG, Silva BA, Marum AA, Bortolotto AL, Belardinelli L, Verrier RL. Pulmonary delivery of flecainide causes a rate-dependent predominant effect on atrial compared with ventricular depolarization duration revealed by intracardiac recordings in an intact porcine model. J Cardiovasc Electrophysiol. 2018 Nov; 29(11):1563-1569. PMID: 30106207.
    Citations:    Fields:    
  4. Marum AA, Silva BA, Bortolotto AL, Silva AC, de Antonio VZ, Belardinelli L, Verrier RL. Optimizing flecainide plasma concentration profile for atrial fibrillation conversion while minimizing adverse ventricular effects by rapid, low-dose intratracheal or intravenous administration. Int J Cardiol. 2019 Jan 01; 274:170-174. PMID: 30217428.
    Citations:    Fields:    
  5. Stocco FG, Evaristo E, Silva AC, de Antonio VZ, Pfeiffer J, Rangachari N, Belardinelli L, Verrier RL. Comparative Pharmacokinetic and Electrocardiographic Effects of Intratracheal and Intravenous Administration of Flecainide in Anesthetized Pigs. J Cardiovasc Pharmacol. 2018 Sep; 72(3):129-135. PMID: 29923887.
    Citations:    Fields:    
  6. Verrier RL. The power of the patch: A smart way to track risk for Torsades de pointes in congenital and drug-induced long QT syndromes? Int J Cardiol. 2018 09 01; 266:145-146. PMID: 29887431.
    Citations:    Fields:    Translation:Humans
  7. Verrier RL, Schachter SC. Is heart disease in chronic epilepsy a consequence of seizures or a fellow traveler? Epilepsy Behav. 2018 09; 86:211-213. PMID: 30153935.
    Citations:    Fields:    
  8. Verrier RL. Ivabradine's Pleiotropic Profile: Can It Protect Against Doxorubicin-Induced Heart Failure? J Cardiovasc Pharmacol. 2018 Jul; 72(1):19-21. PMID: 29738373.
    Citations:    Fields:    
  9. Verrier RL, Bortolotto AL, Silva BA, Marum AA, Stocco FG, Evaristo E, de Antonio VZ, Silva AC, Belardinelli L. Accelerated conversion of atrial fibrillation to normal sinus rhythm by pulmonary delivery of flecainide acetate in a porcine model. Heart Rhythm. 2018 Jun 26. PMID: 29958990.
    Citations:    Fields:    
  10. Verrier RL. Assessing risk for rehospitalization and cardiac death in patients with heart failure: Can the dynamic duo of heart rate turbulence and T-wave alternans help? J Cardiovasc Electrophysiol. 2018 Sep; 29(9):1265-1267. PMID: 29882377.
    Citations:    Fields:    
  11. Takasugi N, Takasugi M, Goto H, Kuwahara T, Nakashima T, Kubota T, Kanamori H, Kawasaki M, Nishigaki K, Minatoguchi S, Verrier RL. Significance of T-wave inversion triggered by spontaneous atrial premature beats in patients with long QT syndrome. Heart Rhythm. 2018 06; 15(6):860-869. PMID: 29427819.
    Citations:    Fields:    Translation:Humans
  12. Kenttä TV, Sinner MF, Nearing BD, Freudling R, Porthan K, Tikkanen JT, Müller-Nurasyid M, Schramm K, Viitasalo M, Jula A, Nieminen MS, Peters A, Salomaa V, Oikarinen L, Verrier RL, Kääb S, Junttila MJ, Huikuri HV. Repolarization Heterogeneity Measured With T-Wave Area Dispersion in Standard 12-Lead ECG Predicts Sudden Cardiac Death in General Population. Circ Arrhythm Electrophysiol. 2018 Feb; 11(2):e005762. PMID: 29440187.
    Citations:    Fields:    
  13. Stocco FG, Evaristo E, Shah NR, Cheezum MK, Hainer J, Foster C, Nearing BD, Gervino E, Verrier RL. Marked exercise-induced T-wave heterogeneity in symptomatic diabetic patients with nonflow-limiting coronary artery stenosis. Ann Noninvasive Electrocardiol. 2018 Mar; 23(2):e12503. PMID: 28949056.
    Citations: 1     Fields:    Translation:Humans
  14. Tan AY, Nearing BD, Rosenberg M, Nezafat R, Josephson ME, Verrier RL. Interlead heterogeneity of R- and T-wave morphology in standard 12-lead ECGs predicts sustained ventricular tachycardia/fibrillation and arrhythmic death in patients with cardiomyopathy. J Cardiovasc Electrophysiol. 2017 Nov; 28(11):1324-1333. PMID: 28675579.
    Citations:    Fields:    Translation:Humans
  15. Evaristo E, Stocco FG, Shah NR, Cheezum MK, Hainer J, Foster C, Nearing BD, Di Carli M, Verrier RL. Ranolazine reduces repolarization heterogeneity in symptomatic patients with diabetes and non-flow-limiting coronary artery stenosis. Ann Noninvasive Electrocardiol. 2018 Jan; 23(1). PMID: 28653394.
    Citations:    Fields:    Translation:Humans
  16. Verrier RL. Statins protect against arrhythmogenic calcium alternans in the post-myocardial infarction diabetic heart: Pleiotropy on steroids. Heart Rhythm. 2017 09; 14(9):1417-1418. PMID: 28606636.
    Citations:    Fields:    Translation:Humans
  17. Verrier RL, Huikuri H. Tracking interlead heterogeneity of R- and T-wave morphology to disclose latent risk for sudden cardiac death. Heart Rhythm. 2017 10; 14(10):1466-1475. PMID: 28610987.
    Citations:    Fields:    Translation:Humans
  18. Verrier RL. Editorial Commentary: Tuning in to sympathetic activity cutaneously in humans-A bench to bedside saga. Trends Cardiovasc Med. 2017 10; 27(7):473-474. PMID: 28709809.
    Citations:    Fields:    
  19. Libbus I, Nearing BD, Amurthur B, KenKnight BH, Verrier RL. Quantitative evaluation of heartbeat interval time series using Poincaré analysis reveals distinct patterns of heart rate dynamics during cycles of vagus nerve stimulation in patients with heart failure. J Electrocardiol. 2017 Nov - Dec; 50(6):898-903. PMID: 28625397.
    Citations: 1     Fields:    Translation:Humans
  20. Steinberg JS, Varma N, Cygankiewicz I, Aziz P, Balsam P, Baranchuk A, Cantillon DJ, Dilaveris P, Dubner SJ, El-Sherif N, Krol J, Kurpesa M, La Rovere MT, Lobodzinski SS, Locati ET, Mittal S, Olshansky B, Piotrowicz E, Saxon L, Stone PH, Tereshchenko L, Turitto G, Wimmer NJ, Verrier RL, Zareba W, Piotrowicz R. 2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry. Heart Rhythm. 2017 07; 14(7):e55-e96. PMID: 28495301.
    Citations: 2     Fields:    
  21. Steinberg JS, Varma N, Cygankiewicz I, Aziz P, Balsam P, Baranchuk A, Cantillon DJ, Dilaveris P, Dubner SJ, El-Sherif N, Krol J, Kurpesa M, La Rovere MT, Lobodzinski SS, Locati ET, Mittal S, Olshansky B, Piotrowicz E, Saxon L, Stone PH, Tereshchenko L, Turakhia MP, Turitto G, Wimmer NJ, Verrier RL, Zareba W, Piotrowicz R. 2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry. Ann Noninvasive Electrocardiol. 2017 05; 22(3). PMID: 28480632.
    Citations: 1     Fields:    Translation:Humans
  22. Silva AF, Bonatti R, Batatinha JA, Nearing BD, Zeng D, Belardinelli L, Verrier RL. The Selective Late Sodium Current Inhibitor Eleclazine, Unlike Amiodarone, Does Not Alter Defibrillation Threshold or Dominant Frequency of Ventricular Fibrillation. J Cardiovasc Pharmacol. 2017 Mar; 69(3):178-182. PMID: 28045761.
    Citations:    Fields:    Translation:Animals
  23. Carlson GM, Libbus I, Amurthur B, KenKnight BH, Verrier RL. Novel method to assess intrinsic heart rate recovery in ambulatory ECG recordings tracks cardioprotective effects of chronic autonomic regulation therapy in patients enrolled in the ANTHEM-HF study. Ann Noninvasive Electrocardiol. 2017 Sep; 22(5). PMID: 28213914.
    Citations:    Fields:    Translation:Humans
  24. de Oliveira Antunes M, Samesima N, Pereira Filho HG, Matsumoto AY, Verrier RL, Pastore CA, Arteaga-Fernández E, Mady C. Exercise-induced quantitative microvolt T-wave alternans in hypertrophic cardiomyopathy. J Electrocardiol. 2017 Mar - Apr; 50(2):184-190. PMID: 27916321.
    Citations: 1     Fields:    Translation:Humans
  25. Bacic D, Carneiro JS, Bento AA, Nearing BD, Rajamani S, Belardinelli L, Verrier RL. Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model. Heart Rhythm. 2017 03; 14(3):448-454. PMID: 27777148.
    Citations: 3     Fields:    Translation:Animals
  26. Verrier RL, Nearing BD, Olin B, Boon P, Schachter SC. Baseline elevation and reduction in cardiac electrical instability assessed by quantitative T-wave alternans in patients with drug-resistant epilepsy treated with vagus nerve stimulation in the AspireSR E-36 trial. Epilepsy Behav. 2016 09; 62:85-9. PMID: 27450311.
    Citations: 2     Fields:    Translation:Humans
  27. Nearing BD, Libbus I, Amurthur B, Kenknight BH, Verrier RL. Acute Autonomic Engagement Assessed by Heart Rate Dynamics During Vagus Nerve Stimulation in Patients With Heart Failure in the ANTHEM-HF Trial. J Cardiovasc Electrophysiol. 2016 09; 27(9):1072-7. PMID: 27221316.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  28. Verrier RL. Commentary: Sudden Cardiac Risk Stratification with Electrocardiographic Indices - A Review on Computational Processing, Technology Transfer, and Scientific Evidence. Front Physiol. 2016; 7:267. PMID: 27458116; PMCID: PMC4932814.
    Citations:    
  29. Justo F, Fuller H, Nearing BD, Rajamani S, Belardinelli L, Verrier RL. Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation. Heart Rhythm. 2016 09; 13(9):1860-7. PMID: 27317981.
    Citations: 3     Fields:    Translation:Animals
  30. Fuller H, Justo F, Nearing BD, Kahlig KM, Rajamani S, Belardinelli L, Verrier RL. Eleclazine, a new selective cardiac late sodium current inhibitor, confers concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in an intact porcine model. Heart Rhythm. 2016 08; 13(8):1679-86. PMID: 27108587.
    Citations: 2     Fields:    Translation:Animals
  31. Kaplan RM, Herzog CA, Larive B, Subacius H, Nearing BD, Verrier R, Passman RS. T-Wave Alternans, Heart Rate Turbulence, and Ventricular Ectopy in Standard versus Daily Hemodialysis: Results from the FHN Daily Trial. Ann Noninvasive Electrocardiol. 2016 Nov; 21(6):566-571. PMID: 27778458.
    Citations:    Fields:    Translation:Humans
  32. Verrier RL, Sroubek J. Quantitative T-wave alternans analysis for sudden cardiac death risk assessment and guiding therapy: answered and unanswered questions: For: Proceedings of ICE2015 Comandatuba, Brazil, Sudden Death Symposium. J Electrocardiol. 2016 May-Jun; 49(3):429-38. PMID: 26987616.
    Citations: 1     Fields:    Translation:Humans
  33. Takasugi N, Goto H, Takasugi M, Verrier RL, Kuwahara T, Kubota T, Toyoshi H, Nakashima T, Kawasaki M, Nishigaki K, Minatoguchi S. Prevalence of Microvolt T-Wave Alternans in Patients With Long QT Syndrome and Its Association With Torsade de Pointes. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003206. PMID: 26839386.
    Citations: 3     Fields:    Translation:Humans
  34. Mewton N, Strauss DG, Rizzi P, Verrier RL, Liu CY, Tereshchenko LG, Nearing B, Volpe GJ, Marchlinski FE, Moxley J, Killian T, Wu KC, Spooner P, Lima JA. Screening for Cardiac Magnetic Resonance Scar Features by 12-Lead ECG, in Patients with Preserved Ejection Fraction. Ann Noninvasive Electrocardiol. 2016 Jan; 21(1):49-59. PMID: 26806840; PMCID: PMC4684490.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  35. Libbus I, Nearing BD, Amurthur B, KenKnight BH, Verrier RL. Letter to the Editor--Can reducing quantitative T-wave alternans save lives? Heart Rhythm. 2016 Apr; 13(4):e89. PMID: 26744097.
    Citations:    Fields:    Translation:Humans
  36. Verrier RL, Fuller H, Justo F, Nearing BD, Rajamani S, Belardinelli L. Unmasking atrial repolarization to assess alternans, spatiotemporal heterogeneity, and susceptibility to atrial fibrillation. Heart Rhythm. 2016 Apr; 13(4):953-61. PMID: 26592850.
    Citations: 2     Fields:    Translation:Animals
  37. Kenttä TV, Nearing BD, Porthan K, Tikkanen JT, Viitasalo M, Nieminen MS, Salomaa V, Oikarinen L, Jula A, Kontula K, Newton-Cheh C, Huikuri HV, Verrier RL. Prediction of sudden cardiac death with automated high-throughput analysis of heterogeneity in standard resting 12-lead electrocardiograms. Heart Rhythm. 2016 Mar; 13(3):713-20. PMID: 26616400.
    Citations:    Fields:    Translation:HumansPHPublic Health
  38. Libbus I, Nearing BD, Amurthur B, KenKnight BH, Verrier RL. Autonomic regulation therapy suppresses quantitative T-wave alternans and improves baroreflex sensitivity in patients with heart failure enrolled in the ANTHEM-HF study. Heart Rhythm. 2016 Mar; 13(3):721-8. PMID: 26601770.
    Citations: 3     Fields:    Translation:Humans
  39. Carneiro JS, Bento AS, Bacic D, Nearing BD, Rajamani S, Belardinelli L, Verrier RL. The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model. J Cardiovasc Electrophysiol. 2015 Dec; 26(12):1364-9. PMID: 26331943.
    Citations: 5     Fields:    Translation:Animals
  40. Verrier RL. Critical neurocircuitry mediating cardiovascular diseases and strategies for intervention. Trends Cardiovasc Med. 2016 Apr; 26(3):258-9. PMID: 26299949.
    Citations:    Fields:    Translation:Humans
  41. Alves Bento AS, Bacic D, Saran Carneiro J, Nearing BD, Fuller H, Justo FA, Rajamani S, Belardinelli L, Verrier RL. Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model. Heart Rhythm. 2015 Dec; 12(12):2508-14. PMID: 26190314.
    Citations: 6     Fields:    Translation:Animals
  42. Verrier RL. What can mechanics teach electricians about arrhythmias in heart failure? Heart Rhythm. 2015 Oct; 12(10):2184-5. PMID: 26051532.
    Citations:    Fields:    Translation:Animals
  43. Verrier RL, Silva AF, Bonatti R, Batatinha JA, Nearing BD, Liu G, Rajamani S, Zeng D, Belardinelli L. Combined actions of ivabradine and ranolazine reduce ventricular rate during atrial fibrillation. J Cardiovasc Electrophysiol. 2015 Mar; 26(3):329-35. PMID: 25346368.
    Citations: 4     Fields:    Translation:Animals
  44. Schomer AC, Nearing BD, Schachter SC, Verrier RL. Vagus nerve stimulation reduces cardiac electrical instability assessed by quantitative T-wave alternans analysis in patients with drug-resistant focal epilepsy. Epilepsia. 2014 Dec; 55(12):1996-2002. PMID: 25470430.
    Citations: 6     Fields:    Translation:Humans
  45. Minkkinen M, Nieminen T, Verrier RL, Leino J, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Kähönen M. Prognostic capacity of a clinically indicated exercise test for cardiovascular mortality is enhanced by combined analysis of exercise capacity, heart rate recovery and T-wave alternans. Eur J Prev Cardiol. 2015 Sep; 22(9):1162-70. PMID: 25366884.
    Citations: 3     Fields:    Translation:Humans
  46. Verrier RL, Malik M. Quantitative T-wave alternans analysis for guiding medical therapy: an underexploited opportunity. Trends Cardiovasc Med. 2015 Apr; 25(3):201-13. PMID: 25541329.
    Citations: 5     Fields:    Translation:Humans
  47. Nearing BD, Verrier RL. Multilead template-derived residua of surface ECGS for quantitative assessment of arrhythmia risk. Ann Noninvasive Electrocardiol. 2015 May; 20(3):273-81. PMID: 25236344.
    Citations:    Fields:    Translation:Humans
  48. Verrier RL, Bonatti R, Silva AF, Batatinha JA, Nearing BD, Liu G, Rajamani S, Zeng D, Belardinelli L. If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation. Heart Rhythm. 2014 Dec; 11(12):2288-96. PMID: 25111327.
    Citations: 5     Fields:    Translation:Animals
  49. Takasugi N, Goto H, Kuwahara T, Verrier RL. Sudden paradoxical QT-interval prolongation exacerbating T-wave alternans in a patient with type 3 long QT syndrome. Ann Noninvasive Electrocardiol. 2015 May; 20(3):290-1. PMID: 25039471.
    Citations:    Fields:    Translation:Humans
  50. Kenttä T, Tulppo MP, Nearing BD, Karjalainen JJ, Hautala AJ, Kiviniemi AM, Huikuri HV, Verrier RL. Effects of exercise rehabilitation on cardiac electrical instability assessed by T-wave alternans during ambulatory electrocardiogram monitoring in coronary artery disease patients without and with diabetes mellitus. Am J Cardiol. 2014 Sep 15; 114(6):832-7. PMID: 25107578.
    Citations: 2     Fields:    Translation:Humans
  51. Bonatti R, Silva AF, Batatinha JA, Sobrado LF, Machado AD, Varone BB, Nearing BD, Belardinelli L, Verrier RL. Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity. Heart Rhythm. 2014 Oct; 11(10):1827-35. PMID: 24953379.
    Citations: 5     Fields:    Translation:Animals
  52. Uchimura-Makita Y, Nakano Y, Tokuyama T, Fujiwara M, Watanabe Y, Sairaku A, Kawazoe H, Matsumura H, Oda N, Ikanaga H, Motoda C, Kajihara K, Oda N, Verrier RL, Kihara Y. Time-domain T-wave alternans is strongly associated with a history of ventricular fibrillation in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2014 Sep; 25(9):1021-1027. PMID: 24761970.
    Citations: 7     Fields:    Translation:Humans
  53. Nieminen T, Scirica BM, Pegler JR, Tavares C, Pagotto VP, Kanas AF, Sobrado MF, Nearing BD, Umez-Eronini AA, Morrow DA, Belardinelli L, Verrier RL. Relation of T-wave alternans to mortality and nonsustained ventricular tachycardia in patients with non-ST-segment elevation acute coronary syndrome from the MERLIN-TIMI 36 trial of ranolazine versus placebo. Am J Cardiol. 2014 Jul 01; 114(1):17-23. PMID: 24852915.
    Citations: 4     Fields:    Translation:Humans
  54. Goto H, Takasugi N, Kuwahara T, Verrier RL. QRST-wave alternans in a child with type 3 long-QT syndrome: an ominous ECG pattern appearing during transition from T-wave alternans to polymorphic VT. J Cardiovasc Electrophysiol. 2014 Jun; 25(6):657-8. PMID: 24383991.
    Citations:    Fields:    Translation:Humans
  55. Verrier RL. Is there a role of MMA T wave alternans test for risk assessment in Brugada syndrome? Anadolu Kardiyol Derg. 2014 Feb; 14(1):96. PMID: 24382500.
    Citations:    Fields:    Translation:Humans
  56. Verrier RL. Ranolazine's sweet side--improvement of glycaemic control by the novel mechanism of skeletal muscle microvascular recruitment. J Physiol. 2013 Oct 15; 591(20):4961. PMID: 24130322; PMCID: PMC3810802.
    Citations:    Fields:    Translation:Animals
  57. Strauss DG, Mewton N, Verrier RL, Nearing BD, Marchlinski FE, Killian T, Moxley J, Tereshchenko LG, Wu KC, Winslow R, Cox C, Spooner PM, Lima JA. Screening entire health system ECG databases to identify patients at increased risk of death. Circ Arrhythm Electrophysiol. 2013 Dec; 6(6):1156-62. PMID: 24122522; PMCID: PMC3992472.
    Citations: 12     Fields:    Translation:Humans
  58. Verrier RL, Ikeda T. Ambulatory ECG-based T-wave alternans monitoring for risk assessment and guiding medical therapy: mechanisms and clinical applications. Prog Cardiovasc Dis. 2013 Sep-Oct; 56(2):172-85. PMID: 24215749.
    Citations: 5     Fields:    Translation:Humans
  59. Verrier RL, Malik M. Electrophysiology of T-wave alternans: mechanisms and pharmacologic influences. J Electrocardiol. 2013 Nov-Dec; 46(6):580-4. PMID: 23948521.
    Citations: 5     Fields:    Translation:HumansAnimals
  60. Verrier RL, Sobrado MF, Pagotto VP, Kanas AF, Machado AD, Varone BB, Sobrado LF, Nearing BD, Zeng D, Belardinelli L. Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation. Heart Rhythm. 2013 Nov; 10(11):1692-7. PMID: 23933296.
    Citations: 5     Fields:    Translation:Animals
  61. Verrier RL, Malik M. Clinical applications of T-wave alternans assessed during exercise stress testing and ambulatory ECG monitoring. J Electrocardiol. 2013 Nov-Dec; 46(6):585-90. PMID: 23870659.
    Citations: 2     Fields:    Translation:Humans
  62. Sobrado LF, Varone BB, Machado AD, Nearing BD, Zeng D, Belardinelli L, Verrier RL. Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect. J Cardiovasc Electrophysiol. 2013 Aug; 24(8):914-8. PMID: 23647933.
    Citations: 4     Fields:    Translation:Animals
  63. Goto H, Takasugi N, Verrier RL, Kuwahara T. T-wave alternans, QRST-wave alternans and atrioventricular block: three consecutive rate-dependent phenomena in a child with congenital long-QT syndrome. J Cardiovasc Electrophysiol. 2013 Oct; 24(10):1183-4. PMID: 23631359.
    Citations:    Fields:    Translation:Humans
  64. Verrier RL, Nearing BD, Ghanem RN, Olson RE, Garberich RF, Katsiyiannis WT, Gornick CC, Tang CY, Henry TD. Elevated T-wave alternans predicts nonsustained ventricular tachycardia in association with percutaneous coronary intervention in ST-segment elevation myocardial infarction (STEMI) patients. J Cardiovasc Electrophysiol. 2013 Jun; 24(6):658-63. PMID: 23445517.
    Citations: 4     Fields:    Translation:Humans
  65. Boink GJ, Duan L, Nearing BD, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Bobkov E, Kryukova Y, Ozgen N, Danilo P, Cohen IS, Verrier RL, Robinson RB, Rosen MR. HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates. J Am Coll Cardiol. 2013 Mar 19; 61(11):1192-201. PMID: 23395072.
    Citations: 17     Fields:    Translation:Animals
  66. Verrier RL, Schmidt G. Independent and complementary utility of ambulatory electrocardiogram-based T-wave alternans and heart rate turbulence for predicting major cardiac events in patients after myocardial infarction. Circ J. 2013; 77(4):1084-5. PMID: 23302771.
    Citations:    Fields:    Translation:Humans
  67. Tan AY, Verrier RL. The role of the autonomic nervous system in cardiac arrhythmias. Handb Clin Neurol. 2013; 117:135-45. PMID: 24095122.
    Citations: 6     Fields:    Translation:HumansAnimals
  68. Verrier RL, Kumar K, Nieminen T, Belardinelli L. Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation. Europace. 2013 Mar; 15(3):317-24. PMID: 23220484; PMCID: PMC3578672.
    Citations: 7     Fields:    Translation:HumansAnimals
  69. Verrier RL, Pagotto VP, Kanas AF, Sobrado MF, Nearing BD, Zeng D, Belardinelli L. Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia. Heart Rhythm. 2013 Jan; 10(1):121-7. PMID: 22985658.
    Citations: 8     Fields:    Translation:Animals
  70. Boink GJ, Nearing BD, Shlapakova IN, Duan L, Kryukova Y, Bobkov Y, Tan HL, Cohen IS, Danilo P, Robinson RB, Verrier RL, Rosen MR. Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2. Circulation. 2012 Jul 31; 126(5):528-36. PMID: 22753192; PMCID: PMC3418050.
    Citations: 16     Fields:    Translation:AnimalsCells
  71. Nearing BD, Mittleman MA, Josephson ME, Verrier RL, Wellenius GA, Burger AJ. Response to letter regarding article, "crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failure". Circ Arrhythm Electrophysiol. 2012 Jun 1; 5(3):e79. PMID: 22715245.
    Citations:    
  72. Verrier RL, Klingenheben T, Malik M, El-Sherif N, Exner DV, Hohnloser SH, Ikeda T, Martínez JP, Narayan SM, Nieminen T, Rosenbaum DS. Microvolt T-wave alternans testing has a role in arrhythmia risk stratification. J Am Coll Cardiol. 2012 Apr 24; 59(17):1572-3. PMID: 22516453.
    Citations: 6     Fields:    Translation:HumansAnimals
  73. Verrier RL, Josephson ME. The stress of sleep in patients prone to atrial tachyarrhythmias. J Cardiovasc Electrophysiol. 2012 Jun; 23(6):612-3. PMID: 22494659.
    Citations:    Fields:    Translation:Humans
  74. Kawaguchi T, Takasugi N, Kubota T, Takasugi M, Kanamori H, Ushikoshi H, Hattori A, Aoyama T, Kawasaki M, Nishigaki K, Takemura G, Minatoguchi S, Verrier RL. In-hospital monitoring of T-wave alternans in a case of amiodarone-induced torsade de pointes: clinical and methodologic insights. Europace. 2012 Sep; 14(9):1372-4. PMID: 22389418.
    Citations:    Fields:    Translation:Humans
  75. Nearing BD, Wellenius GA, Mittleman MA, Josephson ME, Burger AJ, Verrier RL. Crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failure. Circ Arrhythm Electrophysiol. 2012 Feb; 5(1):84-90. PMID: 22157521; PMCID: PMC3296063.
    Citations: 6     Fields:    Translation:Humans
  76. Nieminen T, Tavares CA, Pegler JR, Belardinelli L, Verrier RL. Ranolazine injection into coronary or femoral arteries exerts marked, transient regional vasodilation without systemic hypotension in an intact porcine model. Circ Cardiovasc Interv. 2011 Oct 01; 4(5):481-7. PMID: 21953372.
    Citations: 3     Fields:    Translation:HumansAnimals
  77. Verrier RL, Klingenheben T, Malik M, El-Sherif N, Exner DV, Hohnloser SH, Ikeda T, Martínez JP, Narayan SM, Nieminen T, Rosenbaum DS. Microvolt T-wave alternans physiological basis, methods of measurement, and clinical utility--consensus guideline by International Society for Holter and Noninvasive Electrocardiology. J Am Coll Cardiol. 2011 Sep 20; 58(13):1309-24. PMID: 21920259; PMCID: PMC4111570.
    Citations: 61     Fields:    Translation:HumansAnimals
  78. Takasugi N, Kubota T, Nishigaki K, Verrier RL, Kawasaki M, Takasugi M, Ushikoshi H, Hattori A, Ojio S, Aoyama T, Takemura G, Minatoguchi S. Should T-wave alternans magnitude be corrected with T-wave amplitude in the ultra-short-term prediction of life-threatening cardiac arrhythmias? Europace. 2011 Oct; 13(10):1512-3. PMID: 21846640.
    Citations:    
  79. Takasugi N, Kubota T, Nishigaki K, Verrier RL, Kawasaki M, Takasugi M, Ushikoshi H, Hattori A, Ojio S, Aoyama T, Takemura G, Minatoguchi S. Relationship between T-wave alternans magnitude and T-wave amplitude before the onset of ventricular tachyarrhythmias during emergent reperfusion in acute coronary syndrome patients. Europace. 2011 Oct; 13(10):1511-2; author reply 1512; discussion 1512-3. PMID: 21665920.
    Citations:    Fields:    Translation:Humans
  80. Verrier RL, Nieminen T. T-Wave variability, the new microvolt "buzz" in arrhythmia risk assessment: any links to TWA? J Cardiovasc Electrophysiol. 2011 Jul; 22(7):806-7. PMID: 21352391.
    Citations:    Fields:    Translation:Humans
  81. Takasugi N, Kubota T, Nishigaki K, Verrier RL, Kawasaki M, Takasugi M, Ushikoshi H, Hattori A, Ojio S, Aoyama T, Takemura G, Minatoguchi S. Continuous T-wave alternans monitoring to predict impending life-threatening cardiac arrhythmias during emergent coronary reperfusion therapy in patients with acute coronary syndrome. Europace. 2011 May; 13(5):708-15. PMID: 21317426.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  82. Rosen MR, Verrier RL. To the editor--Biological pacemakers exhibit positive chronotropic response to emotional arousal. Heart Rhythm. 2012 Dec; 9(12):e30. PMID: 21195209.
    Citations:    Fields:    Translation:Animals
  83. Secemsky EA, Verrier RL, Cooke G, Ghossein C, Subacius H, Manuchehry A, Herzog CA, Passman R. High prevalence of cardiac autonomic dysfunction and T-wave alternans in dialysis patients. Heart Rhythm. 2011 Apr; 8(4):592-8. PMID: 21126602.
    Citations: 6     Fields:    Translation:Humans
  84. Nieminen T, Nanbu DY, Datti IP, Vaz GR, Tavares CA, Pegler JR, Nearing BD, Belardinelli L, Verrier RL. Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model. Heart Rhythm. 2011 Apr; 8(4):608-14. PMID: 21094698.
    Citations: 11     Fields:    Translation:Animals
  85. Leino J, Verrier RL, Minkkinen M, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Kähönen M, Nieminen T. Importance of regional specificity of T-wave alternans in assessing risk for cardiovascular mortality and sudden cardiac death during routine exercise testing. Heart Rhythm. 2011 Mar; 8(3):385-90. PMID: 21056698.
    Citations: 4     Fields:    Translation:Humans
  86. Anttila I, Nikus K, Kähönen M, Jula A, Reunanen A, Salomaa V, Nieminen MS, Lehtimäki T, Virtanen V, Verrier RL, Varis J, Sclarovsky S, Nieminen T. Prognostic implications of quantitative ST-segment characteristics and T-wave amplitude for cardiovascular mortality in a general population from the Health 2000 Survey. Ann Med. 2010 Oct; 42(7):502-11. PMID: 20854212.
    Citations: 1     Fields:    Translation:Humans
  87. Verrier RL, Nieminen T, Josephson ME. Antiarrhythmic drug effects on microvolt T-wave alternans: measurement nuisance or indicator of therapeutic action? J Cardiovasc Electrophysiol. 2010 Nov; 21(11):E79. PMID: 20840466.
    Citations:    Fields:    Translation:Humans
  88. Shlapakova IN, Nearing BD, Lau DH, Boink GJ, Danilo P, Kryukova Y, Robinson RB, Cohen IS, Rosen MR, Verrier RL. Biological pacemakers in canines exhibit positive chronotropic response to emotional arousal. Heart Rhythm. 2010 Dec; 7(12):1835-40. PMID: 20708103.
    Citations: 9     Fields:    Translation:AnimalsCells
  89. Verrier RL, Nieminen T. Macroscopic T-wave alternans: the tip of the iceberg in drug-induced torsade de pointes? J Am Coll Cardiol. 2010 Jul 13; 56(3):241; author reply 241-2. PMID: 20620750.
    Citations: 1     Fields:    Translation:Humans
  90. Nieminen T, Verrier RL. Usefulness of T-wave alternans in sudden death risk stratification and guiding medical therapy. Ann Noninvasive Electrocardiol. 2010 Jul; 15(3):276-88. PMID: 20645971.
    Citations: 5     Fields:    Translation:Humans
  91. Verrier RL, Nieminen T. T-wave alternans as a therapeutic marker for antiarrhythmic agents. J Cardiovasc Pharmacol. 2010 Jun; 55(6):544-54. PMID: 20555232.
    Citations: 12     Fields:    Translation:Humans
  92. Verrier RL, Josephson ME. Noninvasive arrhythmia risk assessment in guiding pharmacologic therapy for prevention of sudden cardiac death: where do we stand? Where do we go? J Cardiovasc Pharmacol. 2010 May; 55(5):425-7. PMID: 20224430.
    Citations:    Fields:    Translation:Humans
  93. Nieminen T, Verrier RL, Nikus K, Viik J, Lehtinen R, Lehtimäki T, Kaiser W, Kähönen M. Pattern of crescendo TWA may disclose the underlying cardiac pathology. J Electrocardiol. 2010 Sep-Oct; 43(5):449-51. PMID: 20413129.
    Citations:    Fields:    Translation:Humans
  94. Carvas M, Nascimento BC, Acar M, Nearing BD, Belardinelli L, Verrier RL. Intrapericardial ranolazine prolongs atrial refractory period and markedly reduces atrial fibrillation inducibility in the intact porcine heart. J Cardiovasc Pharmacol. 2010 Mar; 55(3):286-91. PMID: 20075744.
    Citations: 5     Fields:    Translation:Animals
  95. Nieminen T, Verrier RL, Leino J, Nikus K, Lehtinen R, Lehtimäki T, Minkkinen M, Kööbi T, Turjanmaa V, Viik J, Kähönen M. Atrioventricular conduction and cardiovascular mortality: assessment of recovery PR interval is superior to pre-exercise measurement. Heart Rhythm. 2010 Jun; 7(6):796-801. PMID: 20188862.
    Citations: 1     Fields:    Translation:Humans
  96. Verrier RL, Tan A. Heart rate, autonomic markers, and cardiac mortality. Heart Rhythm. 2009 Nov; 6(11 Suppl):S68-75. PMID: 19880076; PMCID: PMC2776094.
    Citations: 19     Fields:    Translation:HumansAnimals
  97. Leino J, Minkkinen M, Nieminen T, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Verrier RL, Kähönen M. Combined assessment of heart rate recovery and T-wave alternans during routine exercise testing improves prediction of total and cardiovascular mortality: the Finnish Cardiovascular Study. Heart Rhythm. 2009 Dec; 6(12):1765-71. PMID: 19959127.
    Citations: 6     Fields:    Translation:Humans
  98. Verrier RL, Josephson ME. Impact of sleep on arrhythmogenesis. Circ Arrhythm Electrophysiol. 2009 Aug; 2(4):450-9. PMID: 19808502; PMCID: PMC2744995.
    Citations: 20     Fields:    Translation:Humans
  99. De Ferrari GM, Verrier RL. Letter by De Ferrari and Verrier regarding article, "Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy". Circulation. 2009 Jul 21; 120(3):e20; author reply e22. PMID: 19620521.
    Citations:    Fields:    Translation:Humans
  100. Zanobetti A, Stone PH, Speizer FE, Schwartz JD, Coull BA, Suh HH, Nearing BD, Mittleman MA, Verrier RL, Gold DR. T-wave alternans, air pollution and traffic in high-risk subjects. Am J Cardiol. 2009 Sep 01; 104(5):665-70. PMID: 19699342; PMCID: PMC3139397.
    Citations: 14     Fields:    Translation:HumansPHPublic Health
  101. Kumar K, Nearing BD, Carvas M, Nascimento BC, Acar M, Belardinelli L, Verrier RL. Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart. J Cardiovasc Electrophysiol. 2009 Jul; 20(7):796-802. PMID: 19298570.
    Citations: 18     Fields:    Translation:Animals
  102. Verrier RL, Kumar K, Nearing BD. Re: Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction: a prospective study. Heart Rhythm. 2009 Apr; 6(4):e1; author reply e1. PMID: 19324300.
    Citations:    Fields:    Translation:Humans
  103. Minkkinen M, Nieminen T, Verrier RL, Leino J, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Kähönen M. Impaired exercise capacity predicts sudden cardiac death in a low-risk population: enhanced specificity with heightened T-wave alternans. Ann Med. 2009; 41(5):380-9. PMID: 19301163.
    Citations:    Fields:    Translation:HumansPHPublic Health
  104. Verrier RL, Kumar K, Nearing BD. Basis for sudden cardiac death prediction by T-wave alternans from an integrative physiology perspective. Heart Rhythm. 2009 Mar; 6(3):416-22. PMID: 19251221; PMCID: PMC2672309.
    Citations: 14     Fields:    Translation:HumansAnimals
  105. Minkkinen M, Kähönen M, Viik J, Nikus K, Lehtimäki T, Lehtinen R, Kööbi T, Turjanmaa V, Kaiser W, Verrier RL, Nieminen T. Enhanced predictive power of quantitative TWA during routine exercise testing in the Finnish Cardiovascular Study. J Cardiovasc Electrophysiol. 2009 Apr; 20(4):408-15. PMID: 19175840.
    Citations: 9     Fields:    Translation:Humans
  106. Bartoli CR, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Akiyama I, Lee LM, Okabe K, Verrier RL, Godleski JJ. Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changes. Environ Health Perspect. 2009 Mar; 117(3):361-6. PMID: 19337509; PMCID: PMC2661904.
    Citations: 35     Fields:    Translation:AnimalsPHPublic Health
  107. Bartoli CR, Wellenius GA, Coull BA, Akiyama I, Diaz EA, Lawrence J, Okabe K, Verrier RL, Godleski JJ. Concentrated ambient particles alter myocardial blood flow during acute ischemia in conscious canines. Environ Health Perspect. 2009 Mar; 117(3):333-7. PMID: 19337504; PMCID: PMC2661899.
    Citations: 12     Fields:    Translation:Animals
  108. Verrier RL, Nearing BD, Kumar K. Computer-aided visualization of microvolt T-wave alternans: "seeing is believing". J Cardiovasc Electrophysiol. 2008 Sep; 19(9):E51-2. PMID: 18662178.
    Citations:    Fields:    Translation:Humans
  109. Verrier RL, Kumar K, Wellenius GA. Predicting cardiac resynchronization therapy response based on endothelial dysfunction: causal link or fellow traveler? Heart Rhythm. 2008 Sep; 5(9):1236-7. PMID: 18774095.
    Citations:    Fields:    Translation:Humans
  110. Kumar K, Nearing BD, Bartoli CR, Kwaku KF, Belardinelli L, Verrier RL. Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart. J Cardiovasc Electrophysiol. 2008 Oct; 19(10):1073-9. PMID: 18479333.
    Citations: 10     Fields:    Translation:Animals
  111. Kumar K, Kwaku KF, Verrier RL. Treatment options for patients with coronary artery disease identified as high risk by T-wave alternans testing. Curr Treat Options Cardiovasc Med. 2008 Feb; 10(1):39-48. PMID: 18325306.
    Citations:    
  112. Verrier RL, Kumar K, Josephson ME. The frustrating search for arrhythmia risk stratifiers in heart failure due to nonischemic cardiomyopathy: does T-wave alternans testing help? J Am Coll Cardiol. 2007 Nov 06; 50(19):1905-6. PMID: 17980259.
    Citations: 2     Fields:    Translation:Humans
  113. Bartoli CR, Akiyama I, Godleski JJ, Verrier RL. Long-term pericardial catheterization is associated with minimum foreign-body response. Catheter Cardiovasc Interv. 2007 Aug 01; 70(2):221-7. PMID: 17632787.
    Citations: 2     Fields:    Translation:HumansAnimals
  114. Nieminen T, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Niemelä K, Turjanmaa V, Kaiser W, Huhtala H, Verrier RL, Huikuri H, Kähönen M. T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test. Eur Heart J. 2007 Oct; 28(19):2332-7. PMID: 17652105.
    Citations: 18