Harvard Catalyst Profiles

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Xin Yuan, D.Sc., M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01CA168393 (BALK, STEVEN P) May 13, 2014 - Apr 30, 2019
    NIH
    SOX9 Mediation of AR and ERG Driven Prostate Cancer
    Role: Co-Principal Investigator
  2. R01DK079962 (YUAN, XIN) Mar 19, 2008 - Feb 28, 2014
    NIH
    SOX9 in prostate cancer development and progression
    Role: Principal Investigator
  3. K01DK064739 (YUAN, XIN) Sep 30, 2003 - Jun 30, 2008
    NIH
    Androgen Receptor and SRY/SOX Interaction in Prostate
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nguyen TM, Thomas LA, Rhoades JL, Ricchi I, Yuan XC, Yuan XC, Sheridan A, Hildebrand DGC, Funke J, Regehr WG, Lee WA. Publisher Correction: Structured cerebellar connectivity supports resilient pattern separation. Nature. 2023 Feb; 614(7946):E18. PMID: 36631615.
    Citations:    Fields:    
  2. Nguyen TM, Thomas LA, Rhoades JL, Ricchi I, Yuan XC, Yuan XC, Sheridan A, Hildebrand DGC, Funke J, Regehr WG, Lee WA. Structured cerebellar connectivity supports resilient pattern separation. Nature. 2023 01; 613(7944):543-549. PMID: 36418404.
    Citations: 2     Fields:    Translation:AnimalsCells
  3. Pettit NL, Yuan XC, Yuan XC, Harvey CD. Hippocampal place codes are gated by behavioral engagement. Nat Neurosci. 2022 05; 25(5):561-566. PMID: 35449355; PMCID: PMC9076532.
    Citations: 4     Fields:    Translation:Animals
  4. Ma F, Arai S, Wang K, Calagua C, Yuan AR, Poluben L, Gu Z, Russo JW, Einstein DJ, Ye H, He MX, Liu Y, Van Allen E, Sowalsky AG, Bhasin MK, Yuan X, Balk SP. Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer. Cancer Res. 2022 04 15; 82(8):1518-1533. PMID: 35131873; PMCID: PMC9018564.
    Citations: 4     Fields:    Translation:HumansCells
  5. Liang J, Wang L, Poluben L, Nouri M, Arai S, Xie L, Voznesensky OS, Cato L, Yuan X, Russo JW, Long HW, Brown M, Chen S, Balk SP. Androgen receptor splice variant 7 functions independently of the full length receptor in prostate cancer cells. Cancer Lett. 2021 10 28; 519:172-184. PMID: 34256096; PMCID: PMC8403646.
    Citations: 8     Fields:    Translation:HumansCells
  6. He MX, Cuoco MS, Crowdis J, Bosma-Moody A, Zhang Z, Bi K, Kanodia A, Su MJ, Ku SY, Garcia MM, Sweet AR, Rodman C, DelloStritto L, Silver R, Steinharter J, Shah P, Izar B, Walk NC, Burke KP, Bakouny Z, Tewari AK, Liu D, Camp SY, Vokes NI, Salari K, Park J, Vigneau S, Fong L, Russo JW, Yuan X, Balk SP, Beltran H, Rozenblatt-Rosen O, Regev A, Rotem A, Taplin ME, Van Allen EM. Transcriptional mediators of treatment resistance in lethal prostate cancer. Nat Med. 2021 03; 27(3):426-433. PMID: 33664492; PMCID: PMC7960507.
    Citations: 34     Fields:    Translation:HumansCells
  7. An JQ, Cheng YW, Guo YC, Wei M, Gong MJ, Tang YL, Yuan XY, Song WF, Mu CY, Zhang AF, Saguner AM, Li GL, Luo GG. Safety and efficacy of remote ischemic postconditioning after thrombolysis in patients with stroke. Neurology. 2020 12 15; 95(24):e3355-e3363. PMID: 33028663.
    Citations: 16     Fields:    Translation:Humans
  8. Poluben L, Puligandla M, Neuberg D, Bryke CR, Hsu Y, Shumeiko O, Yuan X, Voznesensky O, Pihan G, Adam M, Fraenkel E, Rasnic R, Linial M, Klymenko S, Balk SP, Fraenkel PG. Characteristics of myeloproliferative neoplasms in patients exposed to ionizing radiation following the Chernobyl nuclear accident. Am J Hematol. 2019 01; 94(1):62-73. PMID: 30295334.
    Citations: 4     Fields:    Translation:Humans
  9. Chen S, Cai C, Sowalsky AG, Ye H, Ma F, Yuan X, Simon NI, Gray NS, Balk SP. BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer. Cancer Res. 2018 09 15; 78(18):5203-5215. PMID: 30012673; PMCID: PMC6139052.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  10. Sonzogni O, Haynes J, Seifried LA, Kamel YM, Huang K, BeGora MD, Yeung FA, Robert-Tissot C, Heng YJ, Yuan X, Wulf GM, Kron KJ, Wagenblast E, Lupien M, Kislinger T, Hannon GJ, Muthuswamy SK. Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo. PLoS Biol. 2018 06; 16(6):e2004049. PMID: 29924804; PMCID: PMC6042798.
    Citations: 8     Fields:    Translation:AnimalsCells
  11. Zheng Z, Zhang H, Yuan X, Rao C, Zhao Y, Wang Y, Normand SL, Krumholz HM, Hu S. Comparing Outcomes of Coronary Artery Bypass Grafting Among Large Teaching and Urban Hospitals in China and the United States. Circ Cardiovasc Qual Outcomes. 2017 Jun; 10(6). PMID: 28611187.
    Citations: 12     Fields:    Translation:Humans
  12. Liu X, Gao Y, Ye H, Gerrin S, Ma F, Wu Y, Zhang T, Russo J, Cai C, Yuan X, Liu J, Chen S, Balk SP. Positive feedback loop mediated by protein phosphatase 1a mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer. Nucleic Acids Res. 2017 04 20; 45(7):3738-3751. PMID: 28062857; PMCID: PMC5397168.
    Citations: 16     Fields:    Translation:HumansCells
  13. Hu H, Luo ML, Desmedt C, Nabavi S, Yadegarynia S, Hong A, Konstantinopoulos PA, Gabrielson E, Hines-Boykin R, Pihan G, Yuan X, Sotiriou C, Dittmer DP, Fingeroth JD, Wulf GM. Epstein-Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation. EBioMedicine. 2016 Jul; 9:148-160. PMID: 27333046.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  14. Li Q, Guo J, Cao XQ, Yuan X, Rao KQ, Zheng Z, Liu ZD, Hu SS. Trend of non-communicable disease mortality for three common conditions in the elderly population from 2002 to 2010: A population-based study in China. Chronic Dis Transl Med. 2015 Sep; 1(3):152-157. PMID: 29063001; PMCID: PMC5643572.
    Citations: 3     
  15. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 07; 155(4):844-57. PMID: 24209622.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  16. Liu X, Busby J, John C, Wei J, Yuan X, Lu ML. Direct interaction between AR and PAK6 in androgen-stimulated PAK6 activation. PLoS One. 2013; 8(10):e77367. PMID: 24130878.
    Citations: 9     Fields:    Translation:HumansCells
  17. Cai C, Yuan X, Balk SP. Androgen receptor epigenetics. Transl Androl Urol. 2013 Sep 01; 2(3):148-157. PMID: 25580383; PMCID: PMC4286807.
    Citations: 15     
  18. Song SJ, Poliseno L, Song MS, Ala U, Webster K, Ng C, Beringer G, Brikbak NJ, Yuan X, Cantley LC, Richardson AL, Pandolfi PP. MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell. 2013 Jul 18; 154(2):311-324. PMID: 23830207.
    Citations: 251     Fields:    Translation:HumansAnimalsCells
  19. Cai C, Wang H, He HH, Chen S, He L, Ma F, Mucci L, Wang Q, Fiore C, Sowalsky AG, Loda M, Liu XS, Brown M, Balk SP, Yuan X. ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer. J Clin Invest. 2013 Mar; 123(3):1109-22. PMID: 23426182; PMCID: PMC3582143.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  20. Wang H, He L, Ma F, Regan MM, Balk SP, Richardson AL, Yuan X. SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/ß-catenin activation in breast cancer. J Biol Chem. 2013 Mar 01; 288(9):6478-87. PMID: 23306204.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  21. Wang H, Xu Y, Fang Z, Chen S, Balk SP, Yuan X. Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation. PLoS One. 2012; 7(7):e41330. PMID: 22844460.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  22. Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, Cai C, Balk SP, Yuan X. Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation. J Biol Chem. 2012 Jan 13; 287(3):2090-8. PMID: 22139837; PMCID: PMC3265888.
    Citations: 31     Fields:    Translation:AnimalsCells
  23. Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Jänne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS, Brown M. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell. 2009 Jul 23; 138(2):245-56. PMID: 19632176.
    Citations: 492     Fields:    Translation:HumansCells
  24. Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvänen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dörr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Völker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Völzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 2009 Jun; 41(6):666-76. PMID: 19430483; PMCID: PMC2891673.
    Citations: 574     Fields:    Translation:Humans
  25. Yuan X, Balk SP. Mechanisms mediating androgen receptor reactivation after castration. Urol Oncol. 2009 Jan-Feb; 27(1):36-41. PMID: 19111796.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  26. Kaur R, Yuan X, Lu ML, Balk SP. Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate. 2008 Oct 01; 68(14):1510-6. PMID: 18642328.
    Citations: 43     Fields:    Translation:HumansCells
  27. Wang H, Leav I, Ibaragi S, Wegner M, Hu GF, Lu ML, Balk SP, Yuan X. SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion. Cancer Res. 2008 Mar 15; 68(6):1625-30. PMID: 18339840.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  28. Wang H, McKnight NC, Zhang T, Lu ML, Balk SP, Yuan X. SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells. Cancer Res. 2007 Jan 15; 67(2):528-36. PMID: 17234760.
    Citations: 69     Fields:    Translation:HumansCells
  29. Chen S, Xu Y, Yuan X, Bubley GJ, Balk SP. Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15969-74. PMID: 17043241; PMCID: PMC1635111.
    Citations: 101     Fields:    Translation:HumansCells
  30. Yuan X, Li T, Wang H, Zhang T, Barua M, Borgesi RA, Bubley GJ, Lu ML, Balk SP. Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cells. Am J Pathol. 2006 Aug; 169(2):682-96. PMID: 16877366; PMCID: PMC1698802.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  31. Kaur R, Liu X, Gjoerup O, Zhang A, Yuan X, Balk SP, Schneider MC, Lu ML. Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase. J Biol Chem. 2005 Feb 04; 280(5):3323-30. PMID: 15550393.
    Citations: 23     Fields:    Translation:HumansCells
  32. Amir AL, Barua M, McKnight NC, Cheng S, Yuan X, Balk SP. A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4. J Biol Chem. 2003 Aug 15; 278(33):30828-34. PMID: 12799378.
    Citations: 31     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.