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Joel Naom Hirschhorn, M.D., Ph.D.

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Available: 09/01/24, Expires: 09/01/25

Our lab uses a variety of approaches, including computational analysis, clinical research, and basic wet-lab research, to understand the genetic and biological basis of disorders related to endocrinology. Specific projects include (1) computational and genomic analysis to identify causal genes, mechanisms and biological pathways by which noncoding variants affect obesity, short stature, diabetic kidney disease, or Graves Disease; (2) analysis of metabolomic and genetic data to understand the causal connections between diet, metabolite levels, and disease outcomes; (3) functional genomics to identify causal genes and delineate mechanisms by which they regulate skeletal growth or obesity; (4) helping to decipher the genetic basis of hypermobile Ehlers Danlos syndrome; (5) basic mouse and cell culture research to discover the mechanisms by which topiramate suppresses appetite


Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01DK132299 (HIRSCHHORN, JOEL N) Aug 1, 2022 - May 31, 2027
    NIH
    A functional genomics pipeline for genetic discovery in diabetic kidney disease
    Role: Principal Investigator
  2. R01DK127585 (ZIOBROWSKI, HANNAH) Apr 1, 2021 - Jan 31, 2025
    NIH
    Phenotyping obesity using behavioral, psychological, physiological, familial, and genetic data
    Role: Co-Principal Investigator
  3. R01DK125273 (HIRSCHHORN, JOEL N) Aug 12, 2020 - Apr 30, 2025
    NIH
    Metabolomics from a Controlled Feeding Study and Large Cohorts to Identify Diet-Associated Biomarkers, Augmented by Genetics to Infer Causality for Cardiometabolic Outcomes
    Role: Principal Investigator
  4. R01HD089521 (CHAN, YEE-MING) Sep 10, 2016 - May 31, 2021
    NIH
    Exome Sequencing in Disorders of Sex Development: Impact on Patients and Families
    Role: Principal Investigator
  5. R01DK105154 (HIRSCHHORN, JOEL N) Dec 23, 2015 - Nov 30, 2020
    NIH
    Integrative genomic, epigenetic and functional studies in diabetic kidney disease
    Role: Co-Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.