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Barbara Burleigh, Ph.D.

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Mentoring
The Role of Endosomal Regulators and ER-Mediated Phagocytosis in Trypanosoma cruzi Invasion and Vacuole Maturation
Summer, 05/23/05 - 07/31/06

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI146815 (BURLEIGH, BARBARA A) Jun 10, 2019 - May 31, 2021
    NIH/NIAID
    Exploring metabolic resistance to small molecule inhibitors in Trypanosoma cruzi
    Role: Principal Investigator
  2. R21AI135520 (BURLEIGH, BARBARA A) Dec 4, 2017 - Nov 30, 2019
    NIH/NIAID
    Characterization of a novel interaction between intracellular T. cruzi amastigotes and host mitochondria
    Role: Principal Investigator
  3. R01AI114622 (BURLEIGH, BARBARA A) May 1, 2015 - Apr 30, 2020
    NIH/NIAID
    Role of host fatty acid metabolism in Trypanosoma cruzi amastigote growth
    Role: Principal Investigator
  4. R21AI113121 (BURLEIGH, BARBARA A) Jan 1, 2015 - Dec 31, 2016
    NIH/NIAID
    Functional characterization of Trypanosoma cruzi-host cytoskeletal interactions
    Role: Principal Investigator
  5. R21AI099689 (BURLEIGH, BARBARA A) Feb 7, 2012 - Jan 31, 2014
    NIH/NIAID
    Role of host cell metabolism in supporting intracellular Trypanosma cruzi growth
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Clements RL, Streva V, Dumoulin P, Huang W, Owens E, Raj DK, Burleigh B, Llinás M, Winzeler EA, Zhang Q, Dvorin JD. A Novel Antiparasitic Compound Kills Ring-Stage Plasmodium falciparum and Retains Activity Against Artemisinin-Resistant Parasites. J Infect Dis. 2020 Mar 02; 221(6):956-962. PMID: 31616928.
    Citations:    
  2. Dumoulin PC, Burleigh BA. Stress-Induced Proliferation and Cell Cycle Plasticity of Intracellular Trypanosoma cruzi Amastigotes. mBio. 2018 07 10; 9(4). PMID: 29991586.
    Citations:    Fields:    
  3. Gazos-Lopes F, Martin JL, Dumoulin PC, Burleigh BA. Host triacylglycerols shape the lipidome of intracellular trypanosomes and modulate their growth. PLoS Pathog. 2017 12; 13(12):e1006800. PMID: 29281741.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Belew AT, Junqueira C, Rodrigues-Luiz GF, Valente BM, Oliveira AER, Polidoro RB, Zuccherato LW, Bartholomeu DC, Schenkman S, Gazzinelli RT, Burleigh BA, El-Sayed NM, Teixeira SMR. Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection. PLoS Pathog. 2017 12; 13(12):e1006767. PMID: 29240831.
    Citations: 1     Fields:    Translation:HumansAnimals
  5. Lentini G, Dos Santos Pacheco N, Burleigh BA. Targeting host mitochondria: A role for the Trypanosoma cruzi amastigote flagellum. Cell Microbiol. 2018 02; 20(2). PMID: 29119655.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Shah-Simpson S, Lentini G, Dumoulin PC, Burleigh BA. Modulation of host central carbon metabolism and in situ glucose uptake by intracellular Trypanosoma cruzi amastigotes. PLoS Pathog. 2017 Nov; 13(11):e1006747. PMID: 29176805.
    Citations:    Fields:    Translation:HumansAnimals
  7. Shah-Simpson S, Pereira CF, Dumoulin PC, Caradonna KL, Burleigh BA. Bioenergetic profiling of Trypanosoma cruzi life stages using Seahorse extracellular flux technology. Mol Biochem Parasitol. 2016 08; 208(2):91-5. PMID: 27392747.
    Citations: 2     Fields:    Translation:AnimalsCells
  8. Burleigh BA, Boothroyd JC. Editorial overview: Host-microbe interactions: parasites: How eukaryotic parasites meet the challenges of life in a host. Curr Opin Microbiol. 2016 08; 32:viii-xi. PMID: 27372032.
    Citations:    Fields:    Translation:AnimalsCells
  9. Li Y, Shah-Simpson S, Okrah K, Belew AT, Choi J, Caradonna KL, Padmanabhan P, Ndegwa DM, Temanni MR, Corrada Bravo H, El-Sayed NM, Burleigh BA. Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection. PLoS Pathog. 2016 Apr; 12(4):e1005511. PMID: 27046031.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  10. Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J. Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites. Nat Med. 2016 Feb; 22(2):210-6. PMID: 26752517.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  11. Costales JA, Kotton CN, Zurita-Leal AC, Garcia-Perez J, Llewellyn MS, Messenger LA, Bhattacharyya T, Burleigh BA. Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM). Parasit Vectors. 2015 Aug 25; 8:435. PMID: 26303927.
    Citations: 3     Fields:    Translation:HumansAnimals
  12. Padmanabhan PK, Polidoro RB, Barteneva NS, Gazzinelli RT, Burleigh BA. Transient transfection and expression of foreign and endogenous genes in the intracellular stages of Trypanosoma cruzi. Mol Biochem Parasitol. 2014 Dec; 198(2):100-3. PMID: 25712770.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Liu L, Xu YX, Caradonna KL, Kruzel EK, Burleigh BA, Bangs JD, Hirschberg CB. Inhibition of nucleotide sugar transport in Trypanosoma brucei alters surface glycosylation. J Biol Chem. 2013 Apr 12; 288(15):10599-615. PMID: 23443657.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  14. Caradonna KL, Engel JC, Jacobi D, Lee CH, Burleigh BA. Host metabolism regulates intracellular growth of Trypanosoma cruzi. Cell Host Microbe. 2013 Jan 16; 13(1):108-17. PMID: 23332160.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  15. Zhao X, Kumar P, Shah-Simpson S, Caradonna KL, Galjart N, Teygong C, Blader I, Wittmann T, Burleigh BA. Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process. Cell Microbiol. 2013 Apr; 15(4):571-84. PMID: 23107073.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  16. Nagajyothi F, Machado FS, Burleigh BA, Jelicks LA, Scherer PE, Mukherjee S, Lisanti MP, Weiss LM, Garg NJ, Tanowitz HB. Mechanisms of Trypanosoma cruzi persistence in Chagas disease. Cell Microbiol. 2012 May; 14(5):634-43. PMID: 22309180.
    Citations: 49     Fields:    Translation:HumansAnimals
  17. Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. PLoS One. 2011; 6(9):e24434. PMID: 21931713.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  18. Mott GA, Costales JA, Burleigh BA. A soluble factor from Trypanosoma cruzi inhibits transforming growth factor-ß-induced MAP kinase activation and gene expression in dermal fibroblasts. PLoS One. 2011; 6(9):e23482. PMID: 21931601.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  19. Andriani G, Chessler AD, Courtemanche G, Burleigh BA, Rodriguez A. Activity in vivo of anti-Trypanosoma cruzi compounds selected from a high throughput screening. PLoS Negl Trop Dis. 2011 Aug; 5(8):e1298. PMID: 21912715.
    Citations: 19     Fields:    Translation:Animals
  20. Chessler AD, Caradonna KL, Da'dara A, Burleigh BA. Type I interferons increase host susceptibility to Trypanosoma cruzi infection. Infect Immun. 2011 May; 79(5):2112-9. PMID: 21402764.
    Citations: 12     Fields:    Translation:Animals
  21. Caradonna KL, Burleigh BA. Mechanisms of host cell invasion by Trypanosoma cruzi. Adv Parasitol. 2011; 76:33-61. PMID: 21884886.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  22. Costales JA, Daily JP, Burleigh BA. Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling. BMC Genomics. 2009 May 29; 10:252. PMID: 19480704.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  23. Chessler AD, Unnikrishnan M, Bei AK, Daily JP, Burleigh BA. Trypanosoma cruzi triggers an early type I IFN response in vivo at the site of intradermal infection. J Immunol. 2009 Feb 15; 182(4):2288-96. PMID: 19201883.
    Citations: 11     Fields:    Translation:AnimalsCells
  24. Mott A, Lenormand G, Costales J, Fredberg JJ, Burleigh BA. Modulation of host cell mechanics by Trypanosoma cruzi. J Cell Physiol. 2009 Feb; 218(2):315-22. PMID: 18853412.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  25. Samanovic M, Molina-Portela MP, Chessler AD, Burleigh BA, Raper J. Trypanosome lytic factor, an antimicrobial high-density lipoprotein, ameliorates Leishmania infection. PLoS Pathog. 2009 Jan; 5(1):e1000276. PMID: 19165337.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  26. Kawashita SY, da Silva CV, Mortara RA, Burleigh BA, Briones MR. Homology, paralogy and function of DGF-1, a highly dispersed Trypanosoma cruzi specific gene family and its implications for information entropy of its encoded proteins. Mol Biochem Parasitol. 2009 May; 165(1):19-31. PMID: 19393159.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  27. Chessler AD, Ferreira LR, Chang TH, Fitzgerald KA, Burleigh BA. A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts. J Immunol. 2008 Dec 01; 181(11):7917-24. PMID: 19017982.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  28. Mott GA, Burleigh BA. The role of host cell lysosomes in Trypanosoma cruzi invasion. Subcell Biochem. 2008; 47:165-73. PMID: 18512350.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  29. Burleigh B, Soldati-Favre D. Dedication. Subcell Biochem. 2008; 47:vii-viii. PMID: 18581654.
    Citations:    
  30. Burleigh BA, Sinai AP. Molecular mechanisms of parasite invasion. Preface. Subcell Biochem. 2008; 47:xix-xx. PMID: 18512337.
    Citations:    Fields:    Translation:HumansAnimals
  31. Fisch S, Gray S, Heymans S, Haldar SM, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto YM, Pinto Y, Liao R, Jain MK. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7074-9. PMID: 17438289.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  32. Petersen CA, Krumholz KA, Carmen J, Sinai AP, Burleigh BA. Trypanosoma cruzi infection and nuclear factor kappa B activation prevent apoptosis in cardiac cells. Infect Immun. 2006 Mar; 74(3):1580-7. PMID: 16495529.
    Citations: 17     Fields:    Translation:AnimalsCells
  33. Petersen CA, Krumholz KA, Burleigh BA. Toll-like receptor 2 regulates interleukin-1beta-dependent cardiomyocyte hypertrophy triggered by Trypanosoma cruzi. Infect Immun. 2005 Oct; 73(10):6974-80. PMID: 16177377.
    Citations: 19     Fields:    Translation:AnimalsCells
  34. Burleigh BA. Host cell signaling and Trypanosoma cruzi invasion: do all roads lead to lysosomes? Sci STKE. 2005 Jul 19; 2005(293):pe36. PMID: 16030288.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  35. Unnikrishnan M, Burleigh BA. Inhibition of host connective tissue growth factor expression: a novel Trypanosoma cruzi-mediated response. FASEB J. 2004 Nov; 18(14):1625-35. PMID: 15522908.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  36. Woolsey AM, Burleigh BA. Host cell actin polymerization is required for cellular retention of Trypanosoma cruzi and early association with endosomal/lysosomal compartments. Cell Microbiol. 2004 Sep; 6(9):829-38. PMID: 15272864.
    Citations: 22     Fields:    Translation:AnimalsCells
  37. Burleigh BA. Probing Trypanosoma cruzi biology with DNA microarrays. Parasitology. 2004; 128 Suppl 1:S3-10. PMID: 16454896.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  38. Petersen CA, Burleigh BA. Role for interleukin-1 beta in Trypanosoma cruzi-induced cardiomyocyte hypertrophy. Infect Immun. 2003 Aug; 71(8):4441-7. PMID: 12874323.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  39. Woolsey AM, Sunwoo L, Petersen CA, Brachmann SM, Cantley LC, Burleigh BA. Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation. J Cell Sci. 2003 Sep 01; 116(Pt 17):3611-22. PMID: 12876217.
    Citations: 52     Fields:    Translation:AnimalsCells
  40. Burleigh BA, Woolsey AM. Cell signalling and Trypanosoma cruzi invasion. Cell Microbiol. 2002 Nov; 4(11):701-11. PMID: 12427093.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  41. Vaena de Avalos S, Blader IJ, Fisher M, Boothroyd JC, Burleigh BA. Immediate/early response to Trypanosoma cruzi infection involves minimal modulation of host cell transcription. J Biol Chem. 2002 Jan 04; 277(1):639-44. PMID: 11668183.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  42. Caler EV, Morty RE, Burleigh BA, Andrews NW. Dual role of signaling pathways leading to Ca(2+) and cyclic AMP elevation in host cell invasion by Trypanosoma cruzi. Infect Immun. 2000 Dec; 68(12):6602-10. PMID: 11083771.
    Citations: 31     Fields:    Translation:AnimalsCells
  43. Kima PE, Burleigh B, Andrews NW. Surface-targeted lysosomal membrane glycoprotein-1 (Lamp-1) enhances lysosome exocytosis and cell invasion by Trypanosoma cruzi. Cell Microbiol. 2000 Dec; 2(6):477-86. PMID: 11207602.
    Citations: 14     Fields:    Translation:AnimalsCells
  44. Caler EV, Vaena de Avalos S, Haynes PA, Andrews NW, Burleigh BA. Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi. EMBO J. 1998 Sep 01; 17(17):4975-86. PMID: 9724634.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  45. Burleigh BA, Andrews NW. Signaling and host cell invasion by Trypanosoma cruzi. Curr Opin Microbiol. 1998 Aug; 1(4):461-5. PMID: 10066513.
    Citations: 23     Fields:    Translation:AnimalsCells
  46. Burleigh BA, Caler EV, Webster P, Andrews NW. A cytosolic serine endopeptidase from Trypanosoma cruzi is required for the generation of Ca2+ signaling in mammalian cells. J Cell Biol. 1997 Feb 10; 136(3):609-20. PMID: 9024691.
    Citations: 39     Fields:    Translation:AnimalsCells
  47. Gardiner PR, Nene V, Barry MM, Thatthi R, Burleigh B, Clarke MW. Characterization of a small variable surface glycoprotein from Trypanosoma vivax. Mol Biochem Parasitol. 1996 Nov 12; 82(1):1-11. PMID: 8943146.
    Citations: 4     Fields:    Translation:AnimalsCells
  48. Burleigh BA, Andrews NW. A 120-kDa alkaline peptidase from Trypanosoma cruzi is involved in the generation of a novel Ca(2+)-signaling factor for mammalian cells. J Biol Chem. 1995 Mar 10; 270(10):5172-80. PMID: 7890627.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  49. Burleigh BA, Andrews NW. The mechanisms of Trypanosoma cruzi invasion of mammalian cells. Annu Rev Microbiol. 1995; 49:175-200. PMID: 8561458.
    Citations: 43     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.