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John R. David, M.D.

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Title
Institution
Department

Biography
University of ChicagoM.D.1955

Overview
Research

Our groups two main research interests are the immunobiology of cytokines and the control of parasitic infections with a focus on leishmaniasis, We produced recombinant migration inhibitory factor (rMIF), the first lymphokine discovered in the 1960s, and are determining the biological role of the 12kD recombinant cytokine. RMIF has marked effects on the physiology of macrophages, a cell important in the afferent limb of the immune response and in mechanisms of inflammation. Studies by others have shown the presence of MIF-MRNA in numerous cell types suggesting it has other functions as well. They have shown that MIF is important in the pathogenesis of endotoxic shock, inhibits the antiinflammatory effects of corticosteroids, plays a role in the development of the eye, and enhances the secretion of insulin.

Our current studies are focused on understanding the functions of MIF in a genetic-deficient strain of mice that we have recently developed that lacks the MIF gene.

Studies on parasitic diseases now focus on leishmaniasis. Early studies emphasized the bringing of new diagnostic techniques from the laboratory to the field. Recent studies In Brazil have focused on using these techniques to understand the mechanisms of transmission, including defining the importance of dogs as reservoir hosts for leishmaniasis and developing control strategies and trials for immunotherapy and radiowave-induced heat therapy for cutaneous leishmaniasis. In Boston, the work has focused on understanding the mechanisms of immunity using mice that are genetically deficient in cytokines, their receptors, or other relevant molecules, and on maxadilan, a recombinant peptide from the saliva of sand flies, the insect that transmits leishmaniasis. Maxadilan is a potent vasodilator and immunosuppressive molecule which appears to be necessary for the transmission of leishmaniasis. It also can completely prevent the lethal effects of LPS induced endotoxin shock in mice.

Mentoring
The Effects of Deltamethrin PVC Canine Collars on Leismaniasis Control in Baturite, Brasil
International, 06/19/00 - 08/25/00

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AI033226 (DAVID, JOHN R) Aug 1, 1992 - Jul 31, 1995
    NIH
    RECOMBINANT MIF AS AN ADJUVANT FOR HIV ANTIGENS
    Role: Principal Investigator
  2. R13AI031013 (DAVID, JOHN R) Sep 1, 1991 - Aug 31, 1992
    NIH
    AMERICAN SOCIETY FOR TROPICAL MEDICINE AND HYGIENE
    Role: Principal Investigator
  3. T32AI007350 (DAVID, JOHN R) Sep 30, 1989 - Jun 30, 2000
    NIH
    DOCTORAL TRAINING PROGRAM IN TROPICAL DISEASES
    Role: Principal Investigator
  4. R01AI022801 (DAVID, JOHN R) Apr 1, 1985 - Aug 31, 1995
    NIH
    HUMAN RECOMBINANT MIGRATION INHIBITORY FACTOR
    Role: Principal Investigator
  5. P01AI022794 (DAVID, JOHN R) Feb 1, 1985 - Jan 31, 1991
    NIH
    IMMUNOLOGY OF FOUR TROPICAL PARASITIC DISEASES OF MAN
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. David JR. The successful use of radiofrequency-induced heat therapy for cutaneous leishmaniasis: a review. Parasitology. 2018 04; 145(4):527-536. PMID: 29536826.
    Citations: 2     Fields:    Translation:HumansAnimals
  2. Schmidt MQ, David J, Yoshida EJ, Scher K, Mita A, Shiao SL, Ho AS, Zumsteg ZS. Predictors of survival in head and neck mucosal melanoma. Oral Oncol. 2017 10; 73:36-42. PMID: 28939074.
    Citations: 4     Fields:    Translation:Humans
  3. McDevitt MA, Xie J, Ganapathy-Kanniappan S, Griffith J, Liu A, McDonald C, Thuma P, Gordeuk VR, Metz CN, Mitchell R, Keefer J, David J, Leng L, Bucala R. A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J Exp Med. 2015 May 04; 212(5):825. PMID: 25941322.
    Citations:    Fields:    
  4. Leibowitch J, Mathez D, de Truchis P, Ledu D, Melchior JC, Carcelain G, Izopet J, Perronne C, David JR. Four days a week or less on appropriate anti-HIV drug combinations provided long-term optimal maintenance in 94 patients: the ICCARRE project. FASEB J. 2015 Jun; 29(6):2223-34. PMID: 25833895.
    Citations: 1     Fields:    Translation:HumansCells
  5. Braga M, Reddy ST, Vergnes L, Pervin S, Grijalva V, Stout D, David J, Li X, Tomasian V, Reid CB, Norris KC, Devaskar SU, Reue K, Singh R. Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J Lipid Res. 2014 Mar; 55(3):375-84. PMID: 24443561.
    Citations: 29     Fields:    Translation:AnimalsCells
  6. Das R, Koo MS, Kim BH, Jacob ST, Subbian S, Yao J, Leng L, Levy R, Murchison C, Burman WJ, Moore CC, Scheld WM, David JR, Kaplan G, MacMicking JD, Bucala R. Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):E2997-3006. PMID: 23882081.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  7. Xu J, Escamilla J, Mok S, David J, Priceman S, West B, Bollag G, McBride W, Wu L. CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer. Cancer Res. 2013 May 01; 73(9):2782-94. PMID: 23418320.
    Citations: 209     Fields:    Translation:HumansAnimalsCells
  8. Wilson ME, Fregni F, de S M Veras MA, Dyett J, Shei A, Ribeiro GS, David J, Castro MC, Segurado AC, Ko AI, Reis MG. Collaborative teaching and learning: a model for building capacity and partnerships to address NTDs. PLoS Negl Trop Dis. 2011 Mar 29; 5(3):e939. PMID: 21468316.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  9. Wang B, Huang X, Wolters PJ, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, David JR, Bucala R, Shi GP. Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses. J Immunol. 2006 Nov 01; 177(9):5779-84. PMID: 17056501.
    Citations: 14     Fields:    Translation:AnimalsCells
  10. Werneck GL, Costa CH, Walker AM, David JR, Wand M, Maguire JH. Multilevel modelling of the incidence of visceral leishmaniasis in Teresina, Brazil. Epidemiol Infect. 2007 Feb; 135(2):195-201. PMID: 16824254.
    Citations: 24     Fields:    Translation:HumansAnimalsPHPublic Health
  11. McDevitt MA, Xie J, Ganapathy-Kanniappan S, Shanmugasundaram G, Griffith J, Liu A, McDonald C, Thuma P, Gordeuk VR, Metz CN, Mitchell R, Keefer J, David J, Leng L, Bucala R. A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J Exp Med. 2006 May 15; 203(5):1185-96. PMID: 16636133.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  12. Pakozdi A, Amin MA, Haas CS, Martinez RJ, Haines GK, Santos LL, Morand EF, David JR, Koch AE. Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. Arthritis Res Ther. 2006; 8(4):R132. PMID: 16872482.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  13. Gomes RN, Castro-Faria-Neto HC, Bozza PT, Soares MB, Shoemaker CB, David JR, Bozza MT. Calcitonin gene-related peptide inhibits local acute inflammation and protects mice against lethal endotoxemia. Shock. 2005 Dec; 24(6):590-4. PMID: 16317392.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  14. Lobo IM, Soares MB, Correia TM, de Freitas LA, Oliveira MI, Nakatani M, Netto E, Badaro R, David JR. Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy. Trans R Soc Trop Med Hyg. 2006 Jul; 100(7):642-9. PMID: 16274713.
    Citations: 12     Fields:    Translation:HumansCells
  15. Rice EK, Nikolic-Paterson DJ, David JR, Bucala R, Metz CN, Atkins RC, Tesch GH. Macrophage accumulation and renal fibrosis are independent of macrophage migration inhibitory factor in mouse obstructive nephropathy. Nephrology (Carlton). 2004 Oct; 9(5):278-87. PMID: 15504140.
    Citations: 3     Fields:    Translation:AnimalsCells
  16. Gregory JL, Leech MT, David JR, Yang YH, Dacumos A, Hickey MJ. Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice. Arthritis Rheum. 2004 Sep; 50(9):3023-34. PMID: 15457472.
    Citations: 23     Fields:    Translation:AnimalsCells
  17. Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2004 Jun 29; 109(25):3149-53. PMID: 15197138.
    Citations: 50     Fields:    Translation:Animals
  18. dos-Santos WL, David J, Badaró R, de-Freitas LA. Association between skin parasitism and a granulomatous inflammatory pattern in canine visceral leishmaniosis. Parasitol Res. 2004 Jan; 92(2):89-94. PMID: 14610666.
    Citations: 10     Fields:    Translation:Animals
  19. Jose MD, David JR, Atkins RC, Chadban SJ. Blockade of macrophage migration inhibitory factor does not prevent acute renal allograft rejection. Am J Transplant. 2003 Sep; 3(9):1099-106. PMID: 12919089.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Leech M, Lacey D, Xue JR, Santos L, Hutchinson P, Wolvetang E, David JR, Bucala R, Morand EF. Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis. Arthritis Rheum. 2003 Jul; 48(7):1881-9. PMID: 12847682.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  21. Rodríguez-Sosa M, Satoskar AR, David JR, Terrazas LI. Altered T helper responses in CD40 and interleukin-12 deficient mice reveal a critical role for Th1 responses in eliminating the helminth parasite Taenia crassiceps. Int J Parasitol. 2003 Jul; 33(7):703-11. PMID: 12814650.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Rodríguez-Sosa M, Rosas LE, David JR, Bojalil R, Satoskar AR, Terrazas LI. Macrophage migration inhibitory factor plays a critical role in mediating protection against the helminth parasite Taenia crassiceps. Infect Immun. 2003 Mar; 71(3):1247-54. PMID: 12595439.
    Citations: 23     Fields:    Translation:AnimalsCells
  23. Koebernick H, Grode L, David JR, Rohde W, Rolph MS, Mittrücker HW, Kaufmann SH. Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13681-6. PMID: 12271144.
    Citations: 32     Fields:    Translation:AnimalsCells
  24. Werneck GL, Costa CH, Walker AM, David JR, Wand M, Maguire JH. The urban spread of visceral leishmaniasis: clues from spatial analysis. Epidemiology. 2002 May; 13(3):364-7. PMID: 11964941.
    Citations: 20     Fields:    Translation:Humans
  25. Rodriguez-Sosa M, David JR, Bojalil R, Satoskar AR, Terrazas LI. Cutting edge: susceptibility to the larval stage of the helminth parasite Taenia crassiceps is mediated by Th2 response induced via STAT6 signaling. J Immunol. 2002 Apr 01; 168(7):3135-9. PMID: 11907063.
    Citations: 23     Fields:    Translation:AnimalsCells
  26. Costa CH, Stewart JM, Gomes RB, Garcez LM, Ramos PK, Bozza M, Satoskar A, Dissanayake S, Santos RS, Silva MR, Shaw JJ, David JR, Maguire JH. Asymptomatic human carriers of Leishmania chagasi. Am J Trop Med Hyg. 2002 Apr; 66(4):334-7. PMID: 12164285.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  27. Mitchell RA, Liao H, Chesney J, Fingerle-Rowson G, Baugh J, David J, Bucala R. Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):345-50. PMID: 11756671.
    Citations: 210     Fields:    Translation:AnimalsCells
  28. de Jong YP, Abadia-Molina AC, Satoskar AR, Clarke K, Rietdijk ST, Faubion WA, Mizoguchi E, Metz CN, Alsahli M, ten Hove T, Keates AC, Lubetsky JB, Farrell RJ, Michetti P, van Deventer SJ, Lolis E, David JR, Bhan AK, Terhorst C, Sahli MA. Development of chronic colitis is dependent on the cytokine MIF. Nat Immunol. 2001 Nov; 2(11):1061-6. PMID: 11668338.
    Citations: 99     Fields:    Translation:HumansAnimals
  29. David JR, Stamm LM, Bezerra HS, Souza RN, Killick-Kendrick R, Lima JW. Deltamethrin-impregnated dog collars have a potent anti-feeding and insecticidal effect on Lutzomyia longipalpis and Lutzomyia migonei. Mem Inst Oswaldo Cruz. 2001 Aug; 96(6):839-47. PMID: 11562713.
    Citations: 15     Fields:    Translation:Animals
  30. Satoskar AR, Bozza M, Rodriguez Sosa M, Lin G, David JR. Migration-inhibitory factor gene-deficient mice are susceptible to cutaneous Leishmania major infection. Infect Immun. 2001 Feb; 69(2):906-11. PMID: 11159984.
    Citations: 40     Fields:    Translation:Animals
  31. Monteforte GM, Takeda K, Rodriguez-Sosa M, Akira S, David JR, Satoskar AR. Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection. J Immunol. 2000 Jun 01; 164(11):5890-3. PMID: 10820270.
    Citations: 17     Fields:    Translation:AnimalsCells
  32. Satoskar AR, Rodig S, Telford SR, Satoskar AA, Ghosh SK, von Lichtenberg F, David JR. IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology. Eur J Immunol. 2000 Mar; 30(3):834-9. PMID: 10741399.
    Citations: 26     Fields:    Translation:AnimalsCells
  33. Satoskar AR, Stamm LM, Zhang X, Okano M, David JR, Terhorst C, Wang B. NK cell-deficient mice develop a Th1-like response but fail to mount an efficient antigen-specific IgG2a antibody response. J Immunol. 1999 Nov 15; 163(10):5298-302. PMID: 10553052.
    Citations: 11     Fields:    Translation:AnimalsCells
  34. Stamm LM, Satoskar AA, Ghosh SK, David JR, Satoskar AR. STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis. Eur J Immunol. 1999 08; 29(8):2524-9. PMID: 10458767.
    Citations: 21     Fields:    Translation:AnimalsCells
  35. Satoskar AR, Stamm LM, Zhang X, Satoskar AA, Okano M, Terhorst C, David JR, Wang B. Mice lacking NK cells develop an efficient Th1 response and control cutaneous Leishmania major infection. J Immunol. 1999 Jun 01; 162(11):6747-54. PMID: 10352294.
    Citations: 13     Fields:    Translation:AnimalsCells
  36. Bozza M, Satoskar AR, Lin G, Lu B, Humbles AA, Gerard C, David JR. Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J Exp Med. 1999 Jan 18; 189(2):341-6. PMID: 9892616.
    Citations: 160     Fields:    Translation:AnimalsCells
  37. Stamm LM, Räisänen-Sokolowski A, Okano M, Russell ME, David JR, Satoskar AR. Mice with STAT6-targeted gene disruption develop a Th1 response and control cutaneous leishmaniasis. J Immunol. 1998 Dec 01; 161(11):6180-8. PMID: 9834104.
    Citations: 19     Fields:    Translation:AnimalsCells
  38. Bozza M, Soares MB, Bozza PT, Satoskar AR, Diacovo TG, Brombacher F, Titus RG, Shoemaker CB, David JR. The PACAP-type I receptor agonist maxadilan from sand fly saliva protects mice against lethal endotoxemia by a mechanism partially dependent on IL-10. Eur J Immunol. 1998 10; 28(10):3120-7. PMID: 9808180.
    Citations: 10     Fields:    Translation:Animals
  39. Ashford DA, David JR, Freire M, David R, Sherlock I, Eulálio MC, Sampaio DP, Badaro R. Studies on control of visceral leishmaniasis: impact of dog control on canine and human visceral leishmaniasis in Jacobina, Bahia, Brazil. Am J Trop Med Hyg. 1998 Jul; 59(1):53-7. PMID: 9684628.
    Citations: 52     Fields:    Translation:HumansAnimals
  40. Satoskar AR, Okano M, Connaughton S, Raisanen-Sokolwski A, David JR, Labow M. Enhanced Th2-like responses in IL-1 type 1 receptor-deficient mice. Eur J Immunol. 1998 Jul; 28(7):2066-74. PMID: 9692874.
    Citations: 26     Fields:    Translation:AnimalsCells
  41. Soares MB, Titus RG, Shoemaker CB, David JR, Bozza M. The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-alpha and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor. J Immunol. 1998 Feb 15; 160(4):1811-6. PMID: 9469441.
    Citations: 31     Fields:    Translation:AnimalsCells
  42. Satoskar A, Okano M, David JR. Gammadelta T cells are not essential for control of cutaneous Leishmania major infection in genetically resistant C57BL/6 mice. J Infect Dis. 1997 Dec; 176(6):1649-52. PMID: 9395385.
    Citations: 4     Fields:    Translation:AnimalsCells
  43. Soares MB, David JR, Titus RG. An in vitro model for infection with Leishmania major that mimics the immune response in mice. Infect Immun. 1997 Jul; 65(7):2837-45. PMID: 9199457.
    Citations: 5     Fields:    Translation:AnimalsCells
  44. Secor WE, del Corral H, dos Reis MG, Ramos EA, Zimon AE, Matos EP, Reis EA, do Carmo TM, Hirayama K, David RA, David JR, Harn DA. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201. J Infect Dis. 1996 Nov; 174(5):1131-5. PMID: 8896524.
    Citations: 10     Fields:    Translation:Humans
  45. Bozza M, Kolakowski LF, Jenkins NA, Gilbert DJ, Copeland NG, David JR, Gerard C. Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes. Genomics. 1995 Jun 10; 27(3):412-9. PMID: 7558021.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  46. David JR. MIF as a GST. Parasitol Today. 1993 Sep; 9(9):315-6. PMID: 15463791.
    Citations:    Fields:    
  47. Badaro R, Eulalio MC, Benson D, Freire M, Miranda JC, Pedral-Sampaio D, Burns JM, David JR, Johnson WD, Reed SG. Sensitivity and specificity of a recombinant Leishmania chagasi antigen in the serodiagnosis of visceral leishmaniasis. Arch Inst Pasteur Tunis. 1993 Jul-Oct; 70(3-4):331-2. PMID: 7802487.
    Citations: 5     Fields:    Translation:HumansAnimals
  48. Ashford DA, Badaro R, Eulalio C, Freire M, Miranda C, Zalis MG, David JR. Studies on the control of visceral leishmaniasis: validation of the Falcon assay screening test--enzyme-linked immunosorbent assay (FAST-ELISA) for field diagnosis of canine visceral leishmaniasis. Am J Trop Med Hyg. 1993 Jan; 48(1):1-8. PMID: 8427377.
    Citations: 7     Fields:    Translation:Animals
  49. Weiser WY, Pozzi LM, Titus RG, David JR. Recombinant human migration inhibitory factor has adjuvant activity. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):8049-52. PMID: 1518830.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  50. Weiser WY, Pozzi LM, David JR. Human recombinant migration inhibitory factor activates human macrophages to kill Leishmania donovani. J Immunol. 1991 Sep 15; 147(6):2006-11. PMID: 1909737.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  51. David JR. The citizen-scientist: an essential species for our times. Am J Trop Med Hyg. 1991 Mar; 44(3):235-43. PMID: 2035745.
    Citations:    Fields:    
  52. Kahl LP, Byram JE, David JR, Comerford SA, Von Lichtenberg F. Leishmania (Viannia) braziliensis: comparative pathology of golden hamsters infected with isolates from cutaneous and mucosal lesions of patients residing in Tres Bracos, Bahia, Brazil. Am J Trop Med Hyg. 1991 Feb; 44(2):218-32. PMID: 1849379.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  53. Kahl LP, Byram JE, David JR. Leishmania (Viannia) braziliensis isolated from cutaneous and mucosal lesions of patients residing in Tres Bracos, Bahia, Brazil differ in virulence for the golden hamster. Trans R Soc Trop Med Hyg. 1990 Nov-Dec; 84(6):783-4. PMID: 2096506.
    Citations: 3     Fields:    Translation:Animals
  54. Silberstein DS, David JR, Harn DA. The ability of mouse monoclonal antibodies to direct the cytotoxic function of cytokine-activated human eosinophils. Hybridoma. 1990 Jun; 9(3):237-42. PMID: 2194934.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  55. Stein LD, Harn DA, David JR. A cloned ATP:guanidino kinase in the trematode Schistosoma mansoni has a novel duplicated structure. J Biol Chem. 1990 Apr 25; 265(12):6582-8. PMID: 2324092.
    Citations: 9     Fields:    Translation:AnimalsCells
  56. Silberstein DS, Minkoff MS, Creasey AA, David JR. A serum factor that suppresses the cytotoxic function of cytokine-stimulated human eosinophils. J Exp Med. 1990 Mar 01; 171(3):681-93. PMID: 2407799.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  57. Weiser WY, Temple PA, Witek-Giannotti JS, Remold HG, Clark SC, David JR. Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7522-6. PMID: 2552447.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  58. Barker RH, Brandling-Bennett AD, Koech DK, Mugambi M, Khan B, David R, David JR, Wirth DF. Plasmodium falciparum: DNA probe diagnosis of malaria in Kenya. Exp Parasitol. 1989 Oct; 69(3):226-33. PMID: 2676577.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  59. Silberstein DS, Ali MH, Baker SL, David JR. Human eosinophil cytotoxicity-enhancing factor. Purification, physical characteristics, and partial amino acid sequence of an active polypeptide. J Immunol. 1989 Aug 01; 143(3):979-83. PMID: 2745979.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  60. Silberstein DS, Schoof DD, Rodrick ML, Tai PC, Spry CJ, David JR, Eberlein TJ. Activation of eosinophils in cancer patients treated with IL-2 and IL-2-generated lymphokine-activated killer cells. J Immunol. 1989 Mar 15; 142(6):2162-7. PMID: 2784151.
    Citations: 9     Fields:    Translation:HumansCells
  61. Patel RJ, Piessens WF, David JR, Wirth DF. A cloned DNA fragment for identification of Mycobacterium tuberculosis. Rev Infect Dis. 1989 Mar-Apr; 11 Suppl 2:S411-9. PMID: 2496456.
    Citations: 1     Fields:    Translation:HumansCells
  62. Van Niel A, Zacks SE, David JR, Remold HG, Weiser WY. Identification and characterization of a non-interferon antileishmanial macrophage activating factor (antileishmanial MAF). Adv Exp Med Biol. 1988; 239:231-7. PMID: 3059767.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  63. Weiser WY, Van Niel A, Clark SC, David JR, Remold HG. Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by human monocyte-derived macrophages. J Exp Med. 1987 Nov 01; 166(5):1436-46. PMID: 3119759.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  64. Silberstein DS, David JR. The regulation of human eosinophil function by cytokines. Immunol Today. 1987; 8(12):380-5. PMID: 25291273.
    Citations: 6     Fields:    
  65. Rocklin RE, Winston CT, David JR. Activation of human blood monocytes by products of sensitized lymphocytes. J Clin Invest. 1974 Feb; 53(2):559-64. PMID: 11344570.
    Citations: 19     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.