Harvard Catalyst Profiles

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Joshua Kueiyu Lin, Sc.D., M.D.

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Dr. Lin is a Pharmacoepidemiologist in the Division of Pharmacoepidemiology and Pharmacoeconomics at the Brigham and Women’s Hospital and a practicing hospitalist at the Massachusetts General Hospital. He is an Assistant Professor at Harvard Medical school and the Executive Director of the Mass General Brigham (MGB) Center for Integrated Healthcare Data Research. In this role, he has built a highly valuable research database, linking multiple health insurance claims data with a variety of clinical data from electronic health records of the MGB institutions. Leading a team of investigators, research scientists, and administrators, he has built an efficient infrastructure that makes these rich data sources readily available for researchers at Harvard Medical School to facilitate scientific discovery. This valuable database has led to multiple publications in high-impact journals and successfully competed NIH research grants. His research has focused on optimal prescribing in vulnerable populations using large routine-care databases and the development of analytical solutions to combat common biases in pharmacoepidemiology. As Principal Investigator (PI) of an NIH-funded R01 research project (1R01LM012594), he has developed and validated an algorithm to identify a high data-completeness cohort to reduce the information bias resulted from missing medical information recorded outside of the study electronic health record (EHR) system and demonstrated this sub-cohort is representative of the remaining population. He is also the PI of an NIH-funded research project (1RF1AG063381, originally 1R01AG063381) aiming to determine the optimal anticoagulation strategy to prevent stroke in older adults with dementia and other high-risk features. He has developed and validated the best-performed prediction score for anticoagulation quality, which can help reduce inappropriate prescribing of warfarin, a highly morbid anticoagulant, to patients susceptible for adverse outcomes. In addition, he is PI of an NIH-funded Ro1 project (1R01LM013204) to develop a data-adaptive analytical framework for reducing confounding bias in studies that leverages a large amount of patient information recorded in the free-text clinical notes and reports for confounding adjustment in comparative effectiveness research (CER). He has published extensively in pharmacoepidemiology methods to minimize common biases and robust CER findings using real-world data. Using a population-based electronic medical record database in the UK, he was among the first investigators who quantified the effectiveness of different gastroprotective strategies among patients on various antithrombotic therapies. He has also published novel methods to improve information bias and confounding adjustment for multi-center survey-based epidemiological studies and produced important evidence to inform the safe use of antibiotics during pregnancy. His long-term career goal is to establish a rigorous and generalizable framework to optimize validity and precision of comparative effectiveness research with detailed evaluation of treatment effect heterogeneity using electronic health records and insurance claims data.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01LM013204 (LIN, JOSHUA K) Jun 1, 2020 - Mar 31, 2025
    Developing scalable algorithms to incorporate unstructured electronic health records for causal inference based on real-world data
    Role: Principal Investigator
  2. RF1AG063381 (LIN, JOSHUA K) May 1, 2019 - Apr 30, 2023
    Assessing the effectiveness of oral anticoagulants in patients with atrial fibrillation at high risk of underutilization due to dementia, recurrent falls, or poor anticoagulation quality
    Role: Principal Investigator
  3. R01AG063381 (LIN, JOSHUA K) May 1, 2019 - Jan 31, 2023
    Assessing the effectiveness of oral anticoagulants in patients with atrial fibrillation at high risk of underutilization due to dementia, recurrent falls, or poor anticoagulation quality
    Role: Principal Investigator
  4. R01LM012594 (LIN, JOSHUA K) Sep 1, 2017 - Aug 31, 2021
    Improving comparative effectiveness research through electronic health records continuity cohorts
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lin KJ, Feldman WB, Wang SV, Pramod Umarje S, D'Andrea E, Tesfaye H, Zabotka LE, Liu J, Desai RJ. Gastrointestinal prophylaxis for COVID-19: an illustration of severe bias arising from inappropriate comparators in observational studies. J Clin Epidemiol. 2022 11; 151:45-52. PMID: 35868493; PMCID: PMC9296251.
    Citations:    Fields:    
  2. Lin KJ, Schneeweiss S, Tesfaye H, D'Andrea E, Liu J, Lii J, Murphy SN, Gagne JJ. Pharmacotherapy for Hospitalized Patients with COVID-19: Treatment Patterns by Disease Severity. Drugs. 2020 Dec; 80(18):1961-1972. PMID: 33151482; PMCID: PMC7643089.
    Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
  3. Lee MP, Glynn RJ, Schneeweiss S, Lin KJ, Patorno E, Barberio J, Levin R, Evers T, Wang SV, Desai RJ. Risk Factors for Heart Failure with Preserved or Reduced Ejection Fraction Among Medicare Beneficiaries: Application of Competing Risks Analysis and Gradient Boosted Model. Clin Epidemiol. 2020; 12:607-616. PMID: 32606986; PMCID: PMC7304674.
    Citations: 5     
  4. Lin KJ, Dvorin E, Kesselheim AS. Prescribing systemic steroids for acute respiratory tract infections in United States outpatient settings: A nationwide population-based cohort study. PLoS Med. 2020 03; 17(3):e1003058. PMID: 32231363; PMCID: PMC7108689.
    Citations: 3     Fields:    Translation:Humans
  5. Fralick M, Colacci M, Schneeweiss S, Huybrechts KF, Lin KJ, Gagne JJ. Effectiveness and Safety of Apixaban Compared With Rivaroxaban for Patients With Atrial Fibrillation in Routine Practice: A Cohort Study. Ann Intern Med. 2020 04 07; 172(7):463-473. PMID: 32150751.
    Citations: 12     Fields:    Translation:Humans
  6. Connolly JG, Gagne JJ, Lin KJ. Evaluating the Impact of Increasing Allowable Inpatient Diagnoses in Medicare Claims Data. Epidemiology. 2020 03; 31(2):e11-e12. PMID: 31764277.
    Citations:    Fields:    Translation:Humans
  7. Lin KJ, Rosenthal GE, Murphy SN, Mandl KD, Jin Y, Glynn RJ, Schneeweiss S. External Validation of an Algorithm to Identify Patients with High Data-Completeness in Electronic Health Records for Comparative Effectiveness Research. Clin Epidemiol. 2020; 12:133-141. PMID: 32099479; PMCID: PMC7007793.
    Citations: 9     
  8. Desai RJ, Lin KJ, Patorno E, Barberio J, Lee M, Levin R, Evers T, Wang SV, Schneeweiss S. Development and Preliminary Validation of a Medicare Claims-Based Model to Predict Left Ventricular Ejection Fraction Class in Patients With Heart Failure. Circ Cardiovasc Qual Outcomes. 2018 12; 11(12):e004700. PMID: 30562067.
    Citations: 9     Fields:    Translation:Humans
  9. Lin KJ, Glynn RJ, Singer DE, Murphy SN, Lii J, Schneeweiss S. Out-of-system Care and Recording of Patient Characteristics Critical for Comparative Effectiveness Research. Epidemiology. 2018 05; 29(3):356-363. PMID: 29283893.
    Citations: 18     Fields:    Translation:Humans
  10. Lin KJ, Singer DE, Glynn RJ, Murphy SN, Lii J, Schneeweiss S. Identifying Patients With High Data Completeness to Improve Validity of Comparative Effectiveness Research in Electronic Health Records Data. Clin Pharmacol Ther. 2018 05; 103(5):899-905. PMID: 28865143; PMCID: PMC6026022.
    Citations: 17     Fields:    Translation:Humans
  11. Lin KJ, Singer DE, Glynn RJ, Blackley S, Zhou L, Liu J, Dube G, Oertel LB, Schneeweiss S. Prediction Score for Anticoagulation Control Quality Among Older Adults. J Am Heart Assoc. 2017 Oct 05; 6(10). PMID: 28982676.
    Citations: 11     Fields:    Translation:Humans
  12. Lin KJ, Cho SI, Tiwari N, Bergman M, Kizer JR, Palma EC, Taub CC. Impact of metabolic syndrome on the risk of atrial fibrillation recurrence after catheter ablation: systematic review and meta-analysis. J Interv Card Electrophysiol. 2014 Apr; 39(3):211-23. PMID: 24346619.
    Citations: 19     Fields:    Translation:Humans
  13. Lin KJ, De Caterina R, García Rodríguez LA. Low-dose aspirin and upper gastrointestinal bleeding in primary versus secondary cardiovascular prevention: a population-based, nested case-control study. Circ Cardiovasc Qual Outcomes. 2014 Jan; 7(1):70-7. PMID: 24254886.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  14. Yau WP, Mitchell AA, Lin KJ, Werler MM, Hernández-Díaz S. Use of decongestants during pregnancy and the risk of birth defects. Am J Epidemiol. 2013 Jul 15; 178(2):198-208. PMID: 23825167.
    Citations: 9     Fields:    Translation:Humans
  15. Lin KJ, Mitchell AA, Yau WP, Louik C, Hernández-Díaz S. Safety of macrolides during pregnancy. Am J Obstet Gynecol. 2013 Mar; 208(3):221.e1-8. PMID: 23254249; PMCID: PMC3581717.
    Citations: 28     Fields:    Translation:Humans
  16. Lin KJ, Mitchell AA, Yau WP, Louik C, Hernández-Díaz S. Maternal exposure to amoxicillin and the risk of oral clefts. Epidemiology. 2012 Sep; 23(5):699-705. PMID: 22766750.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  17. Su YC, Chen CC, Lee YK, Lee JY, Lin KJ. Comparison of video laryngoscopes with direct laryngoscopy for tracheal intubation: a meta-analysis of randomised trials. Eur J Anaesthesiol. 2011 Nov; 28(11):788-95. PMID: 21897263.
    Citations: 33     Fields:    Translation:Humans
  18. Yau WP, Lin KJ, Werler MM, Louik C, Mitchell AA, Hernández-Díaz S. Drug certainty-response in interview-based studies. Pharmacoepidemiol Drug Saf. 2011 Nov; 20(11):1210-6. PMID: 21913281.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  19. Lin KJ, García Rodríguez LA, Hernández-Díaz S. Systematic review of peptic ulcer disease incidence rates: do studies without validation provide reliable estimates? Pharmacoepidemiol Drug Saf. 2011 Jul; 20(7):718-28. PMID: 21626606.
    Citations: 20     Fields:    Translation:Humans
  20. Lin KJ, Cheung WY, Lai JY, Giovannucci EL. The effect of estrogen vs. combined estrogen-progestogen therapy on the risk of colorectal cancer. Int J Cancer. 2012 Jan 15; 130(2):419-30. PMID: 21365647.
    Citations: 59     Fields:    Translation:Humans
  21. Lin KJ, Hernández-Díaz S, García Rodríguez LA. Acid suppressants reduce risk of gastrointestinal bleeding in patients on antithrombotic or anti-inflammatory therapy. Gastroenterology. 2011 Jul; 141(1):71-9. PMID: 21458456.
    Citations: 30     Fields:    Translation:Humans
  22. García Rodríguez LA, Lin KJ, Hernández-Díaz S, Johansson S. Risk of upper gastrointestinal bleeding with low-dose acetylsalicylic acid alone and in combination with clopidogrel and other medications. Circulation. 2011 Mar 15; 123(10):1108-15. PMID: 21357821.
    Citations: 54     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.