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Last Name
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Manoj Bhasin, Ph.D.

TitleAssistant Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Interdisciplinary Med
99 Brookline Ave
Boston MA 02215
Phone617/667-0009
Fax617/667-5276
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 Research 
 research resources
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eagle-i@hms.harvard.edu.
BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center - Core services (6), Instruments (18), Microarrays (1), Protocols (8) and Software (20)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cuiffo BG, Campagne A, Bell GW, Lembo A, Orso F, Lien EC, Bhasin MK, Raimo M, Hanson SE, Marusyk A, El-Ashry D, Hematti P, Polyak K, Mechta-Grigoriou F, Mariani O, Volinia S, Vincent-Salomon A, Taverna D, Karnoub AE. MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis. Cell Stem Cell. 2014 Dec 4; 15(6):762-74.
    View in: PubMed
  2. Dahlke C, Angin M, Müller C, Sharma S, Bhasin MK, Zhuang Y, Addo MM. A Distinct Treg Transcriptome Signature in HIV-1 Elite Controllers Might Contribute to Improved Disease Outcome. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A180.
    View in: PubMed
  3. Moll HP, Lee A, Minussi DC, da Silva CG, Csizmadia E, Bhasin M, Ferran C. A20 Regulates Atherogenic Interferon (IFN)-? Signaling in Vascular Cells by Modulating Basal IFNß Levels. J Biol Chem. 2014 Nov 7; 289(45):30912-24.
    View in: PubMed
  4. Ramesh N, Massaad MJ, Kumar L, Koduru S, Sasahara Y, Anton I, Bhasin M, Libermann T, Geha R. Binding of the WASP/N-WASP-interacting protein WIP to actin regulates focal adhesion assembly and adhesion. Mol Cell Biol. 2014 Jul; 34(14):2600-10.
    View in: PubMed
  5. Koulmanda M, Sampathkumar RS, Bhasin M, Qipo A, Fan Z, Singh G, Movahedi B, Duggan M, Chipashvili V, Strom TB. Prevention of nonimmunologic loss of transplanted islets in monkeys. Am J Transplant. 2014 Jul; 14(7):1543-51.
    View in: PubMed
  6. Zerbini LF, Bhasin MK, de Vasconcellos JF, Paccez JD, Gu X, Kung AL, Libermann TA. Computational repositioning and preclinical validation of pentamidine for renal cell cancer. Mol Cancer Ther. 2014 Jul; 13(7):1929-41.
    View in: PubMed
  7. Denninger JW, Bhasin M, Huffman J, Niles H, Creager M, Pande R, Liberman T, Fricchione G, Benson H, Zusman R. Clinical and genomic effects of a relaxation response-based mind-body intervention in stage I hypertension. J Altern Complement Med. 2014 May; 20(5):A54.
    View in: PubMed
  8. Angin M, Sharma S, King M, Murooka TT, Ghebremichael M, Mempel TR, Walker BD, Bhasin MK, Addo MM. HIV-1 Infection Impairs Regulatory T-Cell Suppressive Capacity on a Per-Cell Basis. J Infect Dis. 2014 Sep 15; 210(6):899-903.
    View in: PubMed
  9. Arredouani MS, Bhasin MK, Sage DR, Dunn LK, Gill MB, Agnani D, Libermann TA, Fingeroth JD. Analysis of Host Gene Expression Changes Reveals Distinct Roles for the Cytoplasmic Domain of the Epstein-Barr Virus Receptor/CD21 in B-Cell Maturation, Activation, and Initiation of Virus Infection. J Virol. 2014 May; 88(10):5559-77.
    View in: PubMed
  10. Black KM, Masuzawa A, Hagberg RC, Khabbaz KR, Trovato ME, Rettagliati VM, Bhasin MK, Dillon ST, Libermann TA, Toumpoulis IK, Levitsky S, McCully JD. Preliminary biomarkers for identification of human ascending thoracic aortic aneurysm. J Am Heart Assoc. 2013; 2(6):e000138.
    View in: PubMed
  11. Skibsted S, Bhasin MK, Aird WC, Shapiro NI. Bench-to-bedside review: Future novel diagnostics for sepsis - a systems biology approach. Crit Care. 2013; 17(5):231.
    View in: PubMed
  12. Dillon ST, Bhasin MK, Feng X, Koh DW, Daoud SS. Quantitative proteomic analysis in HCV-induced HCC reveals sets of proteins with potential significance for racial disparity. J Transl Med. 2013; 11(1):239.
    View in: PubMed
  13. Keslar KS, Lin M, Zmijewska AA, Sigdel TK, Tran TQ, Ma L, Bhasin M, Rao P, Ding R, Iklé DN, Mannon RB, Sarwal MM, Strom TB, Reed EF, Heeger PS, Suthanthiran M, Fairchild RL. Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling. Am J Transplant. 2013 Jul; 13(7):1891-7.
    View in: PubMed
  14. Bhasin MK, Dusek JA, Chang BH, Joseph MG, Denninger JW, Fricchione GL, Benson H, Libermann TA. Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One. 2013; 8(5):e62817.
    View in: PubMed
  15. Reimold FR, Braun N, Zsengellér ZK, Stillman IE, Karumanchi SA, Toka HR, Latus J, Fritz P, Biegger D, Segerer S, Alscher MD, Bhasin MK, Alper SL. Transcriptional patterns in peritoneal tissue of encapsulating peritoneal sclerosis, a complication of chronic peritoneal dialysis. PLoS One. 2013; 8(2):e56389.
    View in: PubMed
  16. Friehs I, Cowan DB, Choi YH, Black KM, Barnett R, Bhasin MK, Daly C, Dillon SJ, Libermann TA, McGowan FX, del Nido PJ, Levitsky S, McCully JD. Pressure-overload hypertrophy of the developing heart reveals activation of divergent gene and protein pathways in the left and right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2013 Mar 1; 304(5):H697-708.
    View in: PubMed
  17. Black KM, Barnett RJ, Bhasin MK, Daly C, Dillon ST, Libermann TA, Levitsky S, McCully JD. Microarray and proteomic analysis of the cardioprotective effects of cold blood cardioplegia in the mature and aged male and female. Physiol Genomics. 2012 Nov 1; 44(21):1027-41.
    View in: PubMed
  18. Koulmanda M, Bhasin M, Fan Z, Hanidziar D, Goel N, Putheti P, Movahedi B, Libermann TA, Strom TB. Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15443-8.
    View in: PubMed
  19. Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP. A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012 Sep 4; 122(9):3088-100.
    View in: PubMed
  20. Bhasin M, Huang Z, Pradhan-Nabzdyk L, Malek JY, LoGerfo PJ, Contreras M, Guthrie P, Csizmadia E, Andersen N, Kocher O, Ferran C, LoGerfo FW. Temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury. PLoS One. 2012; 7(6):e39123.
    View in: PubMed
  21. Koulmanda M, Bhasin M, Awdeh Z, Qipo A, Fan Z, Hanidziar D, Putheti P, Shi H, Csizuadia E, Libermann TA, Strom TB. The role of TNF-a in mice with type 1- and 2- diabetes. PLoS One. 2012; 7(5):e33254.
    View in: PubMed
  22. Paccez JD, Vasques GJ, Correa RG, Vasconcellos JF, Duncan K, Gu X, Bhasin M, Libermann TA, Zerbini LF. The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target. Oncogene. 2013 Feb 7; 32(6):689-98.
    View in: PubMed
  23. Wang X, Zhang L, Goldberg SN, Bhasin M, Brown V, Alsop DC, Signoretti S, Mier JW, Atkins MB, Bhatt RS. High dose intermittent sorafenib shows improved efficacy over conventional continuous dose in renal cell carcinoma. J Transl Med. 2011; 9:220.
    View in: PubMed
  24. Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, Ochiai T, Nadazdin O, Koyama I, Boenisch O, Najafian N, Bhasin MK, Colvin RB, Madsen JC, Strom TB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates. Am J Transplant. 2012 Feb; 12(2):330-40.
    View in: PubMed
  25. Zerbini LF, Tamura RE, Correa RG, Czibere A, Cordeiro J, Bhasin M, Simabuco FM, Wang Y, Gu X, Li L, Sarkar D, Zhou JR, Fisher PB, Libermann TA. Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-?B inhibitors in ovarian cancer therapy. PLoS One. 2011; 6(9):e24285.
    View in: PubMed
  26. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM. PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest. 2011 Oct; 121(10):4003-14.
    View in: PubMed
  27. Yuan L, Sacharidou A, Stratman AN, Le Bras A, Zwiers PJ, Spokes K, Bhasin M, Shih SC, Nagy JA, Molema G, Aird WC, Davis GE, Oettgen P. RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG. Blood. 2011 Jul 28; 118(4):1145-53.
    View in: PubMed
  28. Zhang L, Bhasin M, Schor-Bardach R, Wang X, Collins MP, Panka D, Putheti P, Signoretti S, Alsop DC, Libermann T, Atkins MB, Mier JW, Goldberg SN, Bhatt RS. Resistance of renal cell carcinoma to sorafenib is mediated by potentially reversible gene expression. PLoS One. 2011; 6(4):e19144.
    View in: PubMed
  29. Damrauer SM, Studer P, da Silva CG, Longo CR, Ramsey HE, Csizmadia E, Shrikhande GV, Scali ST, Libermann TA, Bhasin MK, Ferran C. A20 modulates lipid metabolism and energy production to promote liver regeneration. PLoS One. 2011; 6(3):e17715.
    View in: PubMed
  30. Horst D, Gu X, Bhasin M, Yang Q, Verzi M, Lin D, Joseph M, Zhang X, Chen W, Li YP, Shivdasani RA, Libermann TA. Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum. J Biol Chem. 2010 Nov 5; 285(45):35047-55.
    View in: PubMed
  31. Juengel E, Bhasin M, Libermann T, Barth S, Michaelis M, Cinatl J, Jones J, Hudak L, Jonas D, Blaheta RA. Alterations of the gene expression profile in renal cell carcinoma after treatment with the histone deacetylase-inhibitor valproic acid and interferon-alpha. World J Urol. 2011 Dec; 29(6):779-86.
    View in: PubMed
  32. O'Brien KB, Alberich-Jordà M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010 Jul; 137(13):2147-56.
    View in: PubMed
  33. Afkarian M, Bhasin M, Dillon ST, Guerrero MC, Nelson RG, Knowler WC, Thadhani R, Libermann TA. Optimizing a proteomics platform for urine biomarker discovery. Mol Cell Proteomics. 2010 Oct; 9(10):2195-204.
    View in: PubMed
  34. Bhasin M, Yuan L, Keskin DB, Otu HH, Libermann TA, Oettgen P. Bioinformatic identification and characterization of human endothelial cell-restricted genes. BMC Genomics. 2010; 11:342.
    View in: PubMed
  35. Konstantinopoulos PA, Fountzilas E, Goldsmith JD, Bhasin M, Pillay K, Francoeur N, Libermann TA, Gebhardt MC, Spentzos D. Analysis of multiple sarcoma expression datasets: implications for classification, oncogenic pathway activation and chemotherapy resistance. PLoS One. 2010; 5(4):e9747.
    View in: PubMed
  36. Nikolova-Krstevski V, Yuan L, Le Bras A, Vijayaraj P, Kondo M, Gebauer I, Bhasin M, Carman CV, Oettgen P. ERG is required for the differentiation of embryonic stem cells along the endothelial lineage. BMC Dev Biol. 2009; 9:72.
    View in: PubMed
  37. Arredouani MS, Lu B, Bhasin M, Eljanne M, Yue W, Mosquera JM, Bubley GJ, Li V, Rubin MA, Libermann TA, Sanda MG. Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer. Clin Cancer Res. 2009 Sep 15; 15(18):5794-802.
    View in: PubMed
  38. McCully JD, Bhasin MK, Daly C, Guerrero MC, Dillon S, Liberman TA, Cowan DB, Mably JD, McGowan FX, Levitsky S. Transcriptomic and proteomic analysis of global ischemia and cardioprotection in the rabbit heart. Physiol Genomics. 2009 Jul 9; 38(2):125-37.
    View in: PubMed
  39. Lata S, Bhasin M, Raghava GP. MHCBN 4.0: A database of MHC/TAP binding peptides and T-cell epitopes. BMC Res Notes. 2009; 2:61.
    View in: PubMed
  40. Yuan L, Nikolova-Krstevski V, Zhan Y, Kondo M, Bhasin M, Varghese L, Yano K, Carman CV, Aird WC, Oettgen P. Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 gene. Circ Res. 2009 May 8; 104(9):1049-57.
    View in: PubMed
  41. Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H, Flier JS, Strom TB. Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16242-7.
    View in: PubMed
  42. Haram KM, Peltier HJ, Lu B, Bhasin M, Otu HH, Choy B, Regan M, Libermann TA, Latham GJ, Sanda MG, Arredouani MS. Gene expression profile of mouse prostate tumors reveals dysregulations in major biological processes and identifies potential murine targets for preclinical development of human prostate cancer therapy. Prostate. 2008 Oct 1; 68(14):1517-30.
    View in: PubMed
  43. Dusek JA, Otu HH, Wohlhueter AL, Bhasin M, Zerbini LF, Joseph MG, Benson H, Libermann TA. Genomic counter-stress changes induced by the relaxation response. PLoS One. 2008; 3(7):e2576.
    View in: PubMed
  44. Nikolova-Krstevski V, Bhasin M, Otu HH, Libermann T, Oettgen P. Gene expression analysis of embryonic stem cells expressing VE-cadherin (CD144) during endothelial differentiation. BMC Genomics. 2008; 9:240.
    View in: PubMed
  45. Nautiyal J, Garg ML, Kumar MS, Khan AA, Thakur JS, Kumar R. Air pollution and cardiovascular health in Mandi-Gobindgarh, Punjab, India - a pilot study. Int J Environ Res Public Health. 2007 Dec; 4(4):268-82.
    View in: PubMed
  46. Touma M, Antonini V, Kumar M, Osborn SL, Bobenchik AM, Keskin DB, Connolly JE, Grusby MJ, Reinherz EL, Clayton LK. Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 2007 Aug 1; 179(3):1681-92.
    View in: PubMed
  47. Gu X, Zerbini LF, Otu HH, Bhasin M, Yang Q, Joseph MG, Grall F, Onatunde T, Correa RG, Libermann TA. Reduced PDEF expression increases invasion and expression of mesenchymal genes in prostate cancer cells. Cancer Res. 2007 May 1; 67(9):4219-26.
    View in: PubMed
  48. Bhasin M, Lata S, Raghava GP. Searching and mapping of T-cell epitopes, MHC binders, and TAP binders. Methods Mol Biol. 2007; 409:95-112.
    View in: PubMed
  49. Bhasin M, Lata S, Raghava GP. TAPPred prediction of TAP-binding peptides in antigens. Methods Mol Biol. 2007; 409:381-6.
    View in: PubMed
  50. Bhasin M, Raghava GP. A hybrid approach for predicting promiscuous MHC class I restricted T cell epitopes. J Biosci. 2007 Jan; 32(1):31-42.
    View in: PubMed
  51. Lata S, Bhasin M, Raghava GP. Application of machine learning techniques in predicting MHC binders. Methods Mol Biol. 2007; 409:201-15.
    View in: PubMed
  52. Sharma VM, Calvo JA, Draheim KM, Cunningham LA, Hermance N, Beverly L, Krishnamoorthy V, Bhasin M, Capobianco AJ, Kelliher MA. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol Cell Biol. 2006 Nov; 26(21):8022-31.
    View in: PubMed
  53. Shank-Calvo JA, Draheim K, Bhasin M, Kelliher MA. p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice. Oncogene. 2006 May 18; 25(21):3023-31.
    View in: PubMed
  54. Bhasin M, Reinherz EL, Reche PA. Recognition and classification of histones using support vector machine. J Comput Biol. 2006 Jan-Feb; 13(1):102-12.
    View in: PubMed
  55. Bhasin M, Zhang H, Reinherz EL, Reche PA. Prediction of methylated CpGs in DNA sequences using a support vector machine. FEBS Lett. 2005 Aug 15; 579(20):4302-8.
    View in: PubMed
  56. Bhasin M, Raghava GP. Pcleavage: an SVM based method for prediction of constitutive proteasome and immunoproteasome cleavage sites in antigenic sequences. Nucleic Acids Res. 2005 Jul 1; 33(Web Server issue):W202-7.
    View in: PubMed
  57. Kumar M, Bhasin M, Natt NK, Raghava GP. BhairPred: prediction of beta-hairpins in a protein from multiple alignment information using ANN and SVM techniques. Nucleic Acids Res. 2005 Jul 1; 33(Web Server issue):W154-9.
    View in: PubMed
  58. Bhasin M, Raghava GP. GPCRsclass: a web tool for the classification of amine type of G-protein-coupled receptors. Nucleic Acids Res. 2005 Jul 1; 33(Web Server issue):W143-7.
    View in: PubMed
  59. Saha S, Bhasin M, Raghava GP. Bcipep: a database of B-cell epitopes. BMC Genomics. 2005; 6:79.
    View in: PubMed
  60. Bhasin M, Garg A, Raghava GP. PSLpred: prediction of subcellular localization of bacterial proteins. Bioinformatics. 2005 May 15; 21(10):2522-4.
    View in: PubMed
  61. Garg A, Bhasin M, Raghava GP. Support vector machine-based method for subcellular localization of human proteins using amino acid compositions, their order, and similarity search. J Biol Chem. 2005 Apr 15; 280(15):14427-32.
    View in: PubMed
  62. Bhasin M, Raghava GP. Prediction of CTL epitopes using QM, SVM and ANN techniques. Vaccine. 2004 Aug 13; 22(23-24):3195-204.
    View in: PubMed
  63. Bhasin M, Raghava GP. GPCRpred: an SVM-based method for prediction of families and subfamilies of G-protein coupled receptors. Nucleic Acids Res. 2004 Jul 1; 32(Web Server issue):W383-9.
    View in: PubMed
  64. Bhasin M, Raghava GP. ESLpred: SVM-based method for subcellular localization of eukaryotic proteins using dipeptide composition and PSI-BLAST. Nucleic Acids Res. 2004 Jul 1; 32(Web Server issue):W414-9.
    View in: PubMed
  65. Bhasin M, Raghava GP. Classification of nuclear receptors based on amino acid composition and dipeptide composition. J Biol Chem. 2004 May 28; 279(22):23262-6.
    View in: PubMed
  66. Bhasin M, Raghava GP. Analysis and prediction of affinity of TAP binding peptides using cascade SVM. Protein Sci. 2004 Mar; 13(3):596-607.
    View in: PubMed
  67. Bhasin M, Raghava GP. SVM based method for predicting HLA-DRB1*0401 binding peptides in an antigen sequence. Bioinformatics. 2004 Feb 12; 20(3):421-3.
    View in: PubMed
  68. Bhasin M, Raghava GP. Prediction of promiscuous and high-affinity mutated MHC binders. Hybrid Hybridomics. 2003 Aug; 22(4):229-34.
    View in: PubMed
  69. Bhasin M, Singh H, Raghava GP. MHCBN: a comprehensive database of MHC binding and non-binding peptides. Bioinformatics. 2003 Mar 22; 19(5):665-6.
    View in: PubMed
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