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Eva-Maria Ratai, Ph.D.

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The goals of my research are to advance the understanding of central nervous system (CNS) diseases through the application of advanced neuroimaging techniques, specifically, magnetic resonance imaging (MRI) and MR spectroscopy MRS.
Currently, am active in a number of research projects related to brain tumors, hypoxic ischemic injury in neonates, neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), and neuro-developmental disorders such as autism or OCD.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS124065 (OZ, GULIN) Jul 15, 2021 - Jun 30, 2026
    Understanding the long term impact of COVID-19 on the brain through advanced MR imaging and spectroscopy
    Role: Co-Principal Investigator
  2. R01DA047088 (LOGGIA, MARCO LUCIANO) Jul 15, 2018 - Mar 31, 2023
    Imaging neuroglial mechanisms of neuropathic pain-opioid interaction in HIV
    Role: Co-Principal Investigator
  3. R01CA190901 (RATAI, EVA-MARIA) Sep 7, 2015 - Jul 31, 2021
    Identifying Early Failure to Anti-angiogenic Therapy in Recurrent GBM
    Role: Principal Investigator
  4. R21NS059331 (RATAI, EVA-MARIA) Sep 30, 2007 - May 31, 2010
    Role: Principal Investigator
  5. P51RR000164 (SACHS, BENJAMIN PAUL) Jun 1, 1978 - Apr 30, 2013
    Tulane National Primate Research Center
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chandrasekaran J, Petit E, Park YW, du Montcel ST, Joers JM, Deelchand DK, Považan M, Banan G, Valabregue R, Ehses P, Faber J, Coupé P, Onyike CU, Barker PB, Schmahmann JD, Ratai EM, Subramony SH, Mareci TH, Bushara KO, Paulson H, Durr A, Klockgether T, Ashizawa T, Lenglet C, Öz G. Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3. Ann Neurol. 2022 Dec 13. PMID: 36511514.
    Citations:    Fields:    
  2. Hone-Blanchet A, Antal B, McMahon L, Lithen A, Smith NA, Stufflebeam S, Yen YF, Lin A, Jenkins BG, Mujica-Parodi LR, Ratai EM. Acute administration of ketone beta-hydroxybutyrate downregulates 7T proton magnetic resonance spectroscopy-derived levels of anterior and posterior cingulate GABA and glutamate in healthy adults. Neuropsychopharmacology. 2022 Aug 22. PMID: 35995971.
    Citations:    Fields:    
  3. El-Abtah ME, Talati P, Fu M, Chun B, Clark P, Peters A, Ranasinghe A, He J, Rapalino O, Batchelor TT, Gilberto Gonzalez R, Curry WT, Dietrich J, Gerstner ER, Ratai EM. Magnetic resonance spectroscopy outperforms perfusion in distinguishing between pseudoprogression and disease progression in patients with glioblastoma. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac128. PMID: 36071927; PMCID: PMC9446677.
  4. Selvadurai LP, Perlman SL, Wilmot GR, Subramony SH, Gomez CM, Ashizawa T, Paulson HL, Onyike CU, Rosenthal LS, Sair HI, Kuo SH, Ratai EM, Zesiewicz TA, Bushara KO, Öz G, Dietiker C, Geschwind MD, Nelson AB, Opal P, Yacoubian TA, Nopoulos PC, Shakkottai VG, Figueroa KP, Pulst SM, Morrison PE, Schmahmann JD. The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications. Cerebellum. 2022 Aug 12. PMID: 35962273.
    Citations:    Fields:    
  5. El-Abtah ME, Talati P, Dietrich J, Gerstner ER, Ratai EM. Magnetic resonance spectroscopic imaging for detecting metabolic changes in glioblastoma after anti-angiogenic therapy-a systematic literature review. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac103. PMID: 35892047; PMCID: PMC9307101.
  6. Antal B, McMahon LP, Sultan SF, Lithen A, Wexler DJ, Dickerson B, Ratai EM, Mujica-Parodi LR. Type 2 diabetes mellitus accelerates brain aging and cognitive decline: Complementary findings from UK Biobank and meta-analyses. Elife. 2022 05 24; 11. PMID: 35608247; PMCID: PMC9132576.
    Citations:    Fields:    Translation:Humans
  7. Brusaferri L, Alshelh Z, Martins D, Kim M, Weerasekera A, Housman H, Morrissey EJ, Knight PC, Castro-Blanco KA, Albrecht DS, Tseng CE, Zürcher NR, Ratai EM, Akeju O, Makary MM, Catana C, Mercaldo ND, Hadjikhani N, Veronese M, Turkheimer F, Rosen BR, Hooker JM, Loggia ML. The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic. Brain Behav Immun. 2022 05; 102:89-97. PMID: 35181440; PMCID: PMC8847082.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  8. Sari H, Galbusera R, Bonnier G, Lin Y, Alshelh Z, Torrado-Carvajal A, Mukerji SS, Ratai EM, Gandhi RT, Chu JT, Akeju O, Orhurhu V, Salvatore AN, Sherman J, Kwon DS, Walker B, Rosen B, Price JC, Pollak LE, Loggia M, Granziera C. Multimodal Investigation of Neuroinflammation in Aviremic Patients With HIV on Antiretroviral Therapy and HIV Elite Controllers. Neurol Neuroimmunol Neuroinflamm. 2022 03; 9(2). PMID: 35140142; PMCID: PMC8860468.
    Citations: 3     Fields:    Translation:Humans
  9. Deelchand DK, Henry PG, Joers JM, Auerbach EJ, Park YW, Kara F, Ratai EM, Kantarci K, Öz G. Plug-and-play advanced magnetic resonance spectroscopy. Magn Reson Med. 2022 06; 87(6):2613-2620. PMID: 35092085; PMCID: PMC8957599.
    Citations: 1     Fields:    Translation:Humans
  10. El-Abtah ME, Wenke MR, Talati P, Fu M, Kim D, Weerasekera A, He J, Vaynrub A, Vangel M, Rapalino O, Andronesi O, Arrillaga-Romany I, Forst DA, Yen YF, Rosen B, Batchelor TT, Gonzalez RG, Dietrich J, Gerstner ER, Ratai EM. Myo-Inositol Levels Measured with MR Spectroscopy Can Help Predict Failure of Antiangiogenic Treatment in Recurrent Glioblastoma. Radiology. 2022 02; 302(2):410-418. PMID: 34751617; PMCID: PMC8805659.
    Citations: 1     Fields:    Translation:Humans
  11. Weerasekera A, Morrissey E, Kim M, Saha A, Lin Y, Alshelh Z, Torrado-Carvajal A, Albrecht D, Akeju O, Kwon YM, Bedair H, Chen AF, Napadow V, Schreiber K, Ratai EM, Edwards RR, Loggia ML. Thalamic neurometabolite alterations in patients with knee osteoarthritis before and after total knee replacement. Pain. 2021 07 01; 162(7):2014-2023. PMID: 33470749; PMCID: PMC8205967.
    Citations: 4     Fields:    Translation:Humans
  12. Rowe OE, Rangaprakash D, Weerasekera A, Godbole N, Haxton E, James PF, Stephen CD, Barry RL, Eichler FS, Ratai EM. Magnetic resonance imaging and spectroscopy in late-onset GM2-gangliosidosis. Mol Genet Metab. 2021 08; 133(4):386-396. PMID: 34226107; PMCID: PMC8289742.
    Citations: 2     Fields:    Translation:Humans
  13. Lee J, Andronesi OC, Torrado-Carvajal A, Ratai EM, Loggia ML, Weerasekera A, Berry MP, Ellingsen DM, Isaro L, Lazaridou A, Paschali M, Grahl A, Wasan AD, Edwards RR, Napadow V. 3D magnetic resonance spectroscopic imaging reveals links between brain metabolites and multidimensional pain features in fibromyalgia. Eur J Pain. 2021 10; 25(9):2050-2064. PMID: 34102707; PMCID: PMC9176690.
    Citations:    Fields:    Translation:Humans
  14. Talati P, El-Abtah M, Kim D, Dietrich J, Fu M, Wenke M, He J, Natheir SN, Vangel M, Rapalino O, Vaynrub A, Arrillaga-Romany I, Forst DA, Yen YF, Andronesi O, Kalpathy-Cramer J, Rosen B, Batchelor TT, Gonzalez RG, Gerstner ER, Ratai EM. MR spectroscopic imaging predicts early response to anti-angiogenic therapy in recurrent glioblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab060. PMID: 34131648; PMCID: PMC8193903.
    Citations: 2     
  15. Barry RL, Babu S, Anteraper SA, Triantafyllou C, Keil B, Rowe OE, Rangaprakash D, Paganoni S, Lawson R, Dheel C, Cernasov PM, Rosen BR, Ratai EM, Atassi N. Ultra-high field (7T) functional magnetic resonance imaging in amyotrophic lateral sclerosis: a pilot study. Neuroimage Clin. 2021; 30:102648. PMID: 33872993; PMCID: PMC8060594.
    Citations: 4     Fields:    Translation:Humans
  16. Wiggins CJ, Choi C, Li Y, Lin AP, Thakur SB, Ratai EM. Shimming-the forgotten child of in-vivo MR? MAGMA. 2021 04; 34(2):179-181. PMID: 33768364.
    Citations:    Fields:    Translation:Humans
  17. Makary MM, Weerasekara A, Rodham H, Hightower BG, Tseng CJ, Chan J, Chew S, Paganoni S, Ratai EM, Zürcher NR, Hooker JM, Atassi N, Babu S. Comparison of Two Clinical Upper Motor Neuron Burden Rating Scales in ALS Using Quantitative Brain Imaging. ACS Chem Neurosci. 2021 03 03; 12(5):906-916. PMID: 33576234.
    Citations: 3     Fields:    Translation:HumansCells
  18. Lin A, Andronesi O, Bogner W, Choi IY, Coello E, Cudalbu C, Juchem C, Kemp GJ, Kreis R, Krššák M, Lee P, Maudsley AA, Meyerspeer M, Mlynarik V, Near J, Öz G, Peek AL, Puts NA, Ratai EM, Tkác I, Mullins PG. Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations. NMR Biomed. 2021 05; 34(5):e4484. PMID: 33559967; PMCID: PMC8647919.
    Citations: 17     Fields:    Translation:Humans
  19. Andronesi OC, Nicholson K, Jafari-Khouzani K, Bogner W, Wang J, Chan J, Macklin EA, Levine-Weinberg M, Breen C, Schwarzschild MA, Cudkowicz M, Rosen BR, Paganoni S, Ratai EM. Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients. Front Neurol. 2020; 11:590573. PMID: 33343494.
    Citations: 5     
  20. Rapalino O, Weerasekera A, Moum SJ, Eikermann-Haerter K, Edlow BL, Fischer D, Torrado-Carvajal A, Loggia ML, Mukerji SS, Schaefer PW, Gonzalez RG, Lev MH, Ratai EM. Brain MR Spectroscopic Findings in 3 Consecutive Patients with COVID-19: Preliminary Observations. AJNR Am J Neuroradiol. 2021 01; 42(1):37-41. PMID: 33122208.
    Citations: 2     Fields:    Translation:HumansCells
  21. Figueiro Longo MG, Tan CO, Chan ST, Welt J, Avesta A, Ratai E, Mercaldo ND, Yendiki A, Namati J, Chico-Calero I, Parry BA, Drake L, Anderson R, Rauch T, Diaz-Arrastia R, Lev M, Lee J, Hamblin M, Vakoc B, Gupta R. Effect of Transcranial Low-Level Light Therapy vs Sham Therapy Among Patients With Moderate Traumatic Brain Injury: A Randomized Clinical Trial. JAMA Netw Open. 2020 09 01; 3(9):e2017337. PMID: 32926117.
    Citations: 4     Fields:    Translation:Humans
  22. Torrado-Carvajal A, Albrecht DS, Lee J, Andronesi OC, Ratai EM, Napadow V, Loggia ML. Inpainting as a Technique for Estimation of Missing Voxels in Brain Imaging. Ann Biomed Eng. 2021 Jan; 49(1):345-353. PMID: 32632531.
    Citations: 3     Fields:    Translation:Humans
  23. Jung C, Ichesco E, Ratai EM, Gonzalez RG, Burdo T, Loggia ML, Harris RE, Napadow V. Magnetic resonance imaging of neuroinflammation in chronic pain: a role for astrogliosis? Pain. 2020 07; 161(7):1555-1564. PMID: 31990749; PMCID: PMC7305954.
    Citations: 9     Fields:    Translation:Humans
  24. Mujica-Parodi LR, Amgalan A, Sultan SF, Antal B, Sun X, Skiena S, Lithen A, Adra N, Ratai EM, Weistuch C, Govindarajan ST, Strey HH, Dill KA, Stufflebeam SM, Veech RL, Clarke K. Diet modulates brain network stability, a biomarker for brain aging, in young adults. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):6170-6177. PMID: 32127481; PMCID: PMC7084077.
    Citations: 31     Fields:    Translation:Humans
  25. Deelchand DK, Berrington A, Noeske R, Joers JM, Arani A, Gillen J, Schär M, Nielsen JF, Peltier S, Seraji-Bozorgzad N, Landheer K, Juchem C, Soher BJ, Noll DC, Kantarci K, Ratai EM, Mareci TH, Barker PB, Öz G. Across-vendor standardization of semi-LASER for single-voxel MRS at 3T. NMR Biomed. 2021 05; 34(5):e4218. PMID: 31854045; PMCID: PMC7299834.
    Citations: 13     Fields:    Translation:Humans
  26. Wilson M, Andronesi O, Barker PB, Bartha R, Bizzi A, Bolan PJ, Brindle KM, Choi IY, Cudalbu C, Dydak U, Emir UE, Gonzalez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Huppi PS, Hurd RE, Kantarci K, Kauppinen RA, Klomp DWJ, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjanska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Mullins PG, Murdoch JB, Nelson SJ, Noeske R, Öz G, Pan JW, Peet AC, Poptani H, Posse S, Ratai EM, Salibi N, Scheenen TWJ, Smith ICP, Soher BJ, Tkác I, Vigneron DB, Howe FA. Methodological consensus on clinical proton MRS of the brain: Review and recommendations. Magn Reson Med. 2019 08; 82(2):527-550. PMID: 30919510.
    Citations: 83     Fields:    Translation:Humans
  27. Mintzopoulos D, Ratai EM, He J, Gonzalez RG, Kaufman MJ. Simian immunodeficiency virus transiently increases brain temperature in rhesus monkeys: detection with magnetic resonance spectroscopy thermometry. Magn Reson Med. 2019 05; 81(5):2896-2904. PMID: 30652349; PMCID: PMC6414245.
    Citations: 3     Fields:    Translation:AnimalsCells
  28. Nicholson K, Chan J, Macklin EA, Levine-Weinberg M, Breen C, Bakshi R, Grasso DL, Wills AM, Jahandideh S, Taylor AA, Beaulieu D, Ennist DL, Andronesi O, Ratai EM, Schwarzschild MA, Cudkowicz M, Paganoni S. Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2018 Dec; 5(12):1522-1533. PMID: 30564619; PMCID: PMC6292193.
    Citations: 7     Fields:    
  29. Ratai EM, Alshikho MJ, Zürcher NR, Loggia ML, Cebulla CL, Cernasov P, Reynolds B, Fish J, Seth R, Babu S, Paganoni S, Hooker JM, Atassi N. Integrated imaging of [11C]-PBR28 PET, MR diffusion and magnetic resonance spectroscopy 1H-MRS in amyotrophic lateral sclerosis. Neuroimage Clin. 2018; 20:357-364. PMID: 30112276.
    Citations: 20     Fields:    Translation:Humans
  30. Ratai EM, Zhang Z, Fink J, Muzi M, Hanna L, Greco E, Richards T, Kim D, Andronesi OC, Mintz A, Kostakoglu L, Prah M, Ellingson B, Schmainda K, Sorensen G, Barboriak D, Mankoff D, Gerstner ER. ACRIN 6684: Multicenter, phase II assessment of tumor hypoxia in newly diagnosed glioblastoma using magnetic resonance spectroscopy. PLoS One. 2018; 13(6):e0198548. PMID: 29902200; PMCID: PMC6002091.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  31. González RG, Fell R, He J, Campbell J, Burdo TH, Autissier P, Annamalai L, Taheri F, Parker T, Lifson JD, Halpern EF, Vangel M, Masliah E, Westmoreland SV, Williams KC, Ratai EM. Temporal/compartmental changes in viral RNA and neuronal injury in a primate model of NeuroAIDS. PLoS One. 2018; 13(5):e0196949. PMID: 29750804.
    Citations: 7     Fields:    Translation:AnimalsCells
  32. Andronesi OC, Arrillaga-Romany IC, Ly KI, Bogner W, Ratai EM, Reitz K, Iafrate AJ, Dietrich J, Gerstner ER, Chi AS, Rosen BR, Wen PY, Cahill DP, Batchelor TT. Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate. Nat Commun. 2018 04 16; 9(1):1474. PMID: 29662077.
    Citations: 53     Fields:    Translation:HumansCTClinical Trials
  33. Atassi N, Xu M, Triantafyllou C, Keil B, Lawson R, Cernasov P, Ratti E, Long CJ, Paganoni S, Murphy A, Salibi N, Seethamraju R, Rosen B, Ratai EM. Ultra high-field (7tesla) magnetic resonance spectroscopy in Amyotrophic Lateral Sclerosis. PLoS One. 2017; 12(5):e0177680. PMID: 28498852.
    Citations: 24     Fields:    Translation:HumansCells
  34. Rapalino O, Ratai EM. Multiparametric Imaging Analysis: Magnetic Resonance Spectroscopy. Magn Reson Imaging Clin N Am. 2016 Nov; 24(4):671-686. PMID: 27742109.
    Citations: 6     Fields:    Translation:Humans
  35. Prakkamakul S, Witzel T, Huang S, Boulter D, Borja MJ, Schaefer P, Rosen B, Heberlein K, Ratai E, Gonzalez G, Rapalino O. Ultrafast Brain MRI: Clinical Deployment and Comparison to Conventional Brain MRI at 3T. J Neuroimaging. 2016 09; 26(5):503-10. PMID: 27273370.
    Citations: 12     Fields:    Translation:Humans
  36. Mbugua KK, Holmes MJ, Cotton MF, Ratai EM, Little F, Hess AT, Dobbels E, Van der Kouwe AJ, Laughton B, Meintjes EM. HIV-associated CD4+/CD8+ depletion in infancy is associated with neurometabolic reductions in the basal ganglia at age 5 years despite early antiretroviral therapy. AIDS. 2016 06 01; 30(9):1353-62. PMID: 26959509; PMCID: PMC4864158.
    Citations: 17     Fields:    Translation:HumansCells
  37. Gerstner ER, Zhang Z, Fink JR, Muzi M, Hanna L, Greco E, Prah M, Schmainda KM, Mintz A, Kostakoglu L, Eikman EA, Ellingson BM, Ratai EM, Sorensen AG, Barboriak DP, Mankoff DA. ACRIN 6684: Assessment of Tumor Hypoxia in Newly Diagnosed Glioblastoma Using 18F-FMISO PET and MRI. Clin Cancer Res. 2016 Oct 15; 22(20):5079-5086. PMID: 27185374; PMCID: PMC5065740.
    Citations: 45     Fields:    Translation:Humans
  38. Rincon SP, Blitstein MB, Caruso PA, González RG, Thibert RL, Ratai EM. The Use of Magnetic Resonance Spectroscopy in the Evaluation of Pediatric Patients With Seizures. Pediatr Neurol. 2016 05; 58:57-66. PMID: 26948493.
    Citations: 3     Fields:    Translation:Humans
  39. Ratai EM, Gilberto González R. Clinical magnetic resonance spectroscopy of the central nervous system. Handb Clin Neurol. 2016; 135:93-116. PMID: 27432661.
    Citations: 3     Fields:    Translation:Humans
  40. Eichler F, Ratai E, Carroll JJ, Masdeu JC. Inherited or acquired metabolic disorders. Handb Clin Neurol. 2016; 135:603-636. PMID: 27432685.
    Citations: 3     Fields:    Translation:Humans
  41. Robertson CE, Ratai EM, Kanwisher N. Reduced GABAergic Action in the Autistic Brain. Curr Biol. 2016 Jan 11; 26(1):80-5. PMID: 26711497.
    Citations: 120     Fields:    Translation:HumansCells
  42. Wu WE, Babb JS, Tal A, Kirov II, George AE, Ratai EM, Gonzalez RG, Gonen O. Early glial activation precedes neurodegeneration in the cerebral cortex after SIV infection: a 3D, multivoxel proton magnetic resonance spectroscopy study. HIV Med. 2015 Jul; 16(6):381-7. PMID: 25689120.
    Citations: 2     Fields:    Translation:AnimalsCells
  43. Robertson C, Hermann K, Ratai EM, Kanwisher N. GABA Measured in Visual Cortex using MRS Predicts Atypical Dynamics of Binocular Rivalry Associated with Autism. J Vis. 2015; 15(12):917. PMID: 26326605.
  44. Campbell JH, Ratai EM, Autissier P, Nolan DJ, Tse S, Miller AD, González RG, Salemi M, Burdo TH, Williams KC. Anti-a4 antibody treatment blocks virus traffic to the brain and gut early, and stabilizes CNS injury late in infection. PLoS Pathog. 2014 Dec; 10(12):e1004533. PMID: 25502752; PMCID: PMC4263764.
    Citations: 38     Fields:    Translation:AnimalsCells
  45. Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Dinçer A, Dydak U, Emir UE, Frahm J, González RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, Hüppi PS, Hurd RE, Kantarci K, Klomp DW, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjanska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJ, Ratai EM, Ross BD, Scheenen TW, Schuster C, Smith IC, Soher BJ, Tkác I, Vigneron DB, Kauppinen RA. Clinical proton MR spectroscopy in central nervous system disorders. Radiology. 2014 Mar; 270(3):658-79. PMID: 24568703; PMCID: PMC4263653.
    Citations: 211     Fields:    Translation:Humans
  46. Wu WE, Tal A, Zhang K, Babb JS, Ratai EM, González RG, Gonen O. Structure-specific glial response in a macaque model of neuroAIDS: multivoxel proton magnetic resonance spectroscopic imaging at 3 Tesla. AIDS. 2013 Oct 23; 27(16):2519-28. PMID: 23939235.
    Citations: 3     Fields:    Translation:Animals
  47. Caruso PA, Johnson J, Thibert R, Rapalino O, Rincon S, Ratai EM. The use of magnetic resonance spectroscopy in the evaluation of epilepsy. Neuroimaging Clin N Am. 2013 Aug; 23(3):407-24. PMID: 23928197.
    Citations: 3     Fields:    Translation:Humans
  48. Ratai EM, Zhang Z, Snyder BS, Boxerman JL, Safriel Y, McKinstry RC, Bokstein F, Gilbert MR, Sorensen AG, Barboriak DP. Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677. Neuro Oncol. 2013 Jul; 15(7):936-44. PMID: 23645534.
    Citations: 22     Fields:    Translation:Humans
  49. Cohen-Adad J, Zhao W, Keil B, Ratai EM, Triantafyllou C, Lawson R, Dheel C, Wald LL, Rosen BR, Cudkowicz M, Atassi N. 7-T MRI of the spinal cord can detect lateral corticospinal tract abnormality in amyotrophic lateral sclerosis. Muscle Nerve. 2013 May; 47(5):760-2. PMID: 23553571.
    Citations: 14     Fields:    Translation:HumansCells
  50. Wu WE, Tal A, Kirov II, Rusinek H, Charytonowicz D, Babb JS, Ratai EM, Gilberto Gonzalez R, Gonen O. Global gray and white matter metabolic changes after simian immunodeficiency virus infection in CD8-depleted rhesus macaques: proton MRS imaging at 3 T. NMR Biomed. 2013 Apr; 26(4):480-8. PMID: 23418159.
    Citations: 1     Fields:    Translation:AnimalsCells
  51. Westmoreland SV, Annamalai L, Lentz MR, Ratai EM, Assaf B, Boisvert K, Huynh T, Vallender EJ, Miller GM, Madras BK, Gonzalez RG. Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques. J Neurovirol. 2011 Oct; 17(5):455-68. PMID: 21789725.
    Citations: 1     Fields:    Translation:AnimalsCells
  52. Kim H, Catana C, Ratai EM, Andronesi OC, Jennings DL, Batchelor TT, Jain RK, Sorensen AG. Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma. Cancer Res. 2011 Jun 01; 71(11):3745-52. PMID: 21507932.
    Citations: 29     Fields:    Translation:HumansCTClinical Trials
  53. Campbell JH, Burdo TH, Autissier P, Bombardier JP, Westmoreland SV, Soulas C, González RG, Ratai EM, Williams KC. Minocycline inhibition of monocyte activation correlates with neuronal protection in SIV neuroAIDS. PLoS One. 2011 Apr 06; 6(4):e18688. PMID: 21494695.
    Citations: 38     Fields:    Translation:AnimalsCells
  54. Ratai EM, Pilkenton S, He J, Fell R, Bombardier JP, Joo CG, Lentz MR, Kim WK, Burdo TH, Autissier P, Annamalai L, Curran E, O'Neil SP, Westmoreland SV, Williams KC, Masliah E, Gilberto González R. CD8+ lymphocyte depletion without SIV infection does not produce metabolic changes or pathological abnormalities in the rhesus macaque brain. J Med Primatol. 2011 Oct; 40(5):300-9. PMID: 21463330.
    Citations: 13     Fields:    Translation:AnimalsCells
  55. Ratai EM, Annamalai L, Burdo T, Joo CG, Bombardier JP, Fell R, Hakimelahi R, He J, Lentz MR, Campbell J, Curran E, Halpern EF, Masliah E, Westmoreland SV, Williams KC, González RG. Brain creatine elevation and N-Acetylaspartate reduction indicates neuronal dysfunction in the setting of enhanced glial energy metabolism in a macaque model of neuroAIDS. Magn Reson Med. 2011 Sep; 66(3):625-34. PMID: 21381104.
    Citations: 29     Fields:    Translation:AnimalsCells
  56. Wu WE, Kirov II, Zhang K, Babb JS, Joo CG, Ratai EM, González RG, Gonen O. Cross-sectional and longitudinal reproducibility of rhesus macaque brain metabolites: a proton MR spectroscopy study at 3 T. Magn Reson Med. 2011 Jun; 65(6):1522-31. PMID: 21337426.
    Citations: 1     Fields:    Translation:Animals
  57. Atassi N, Ratai EM, Greenblatt DJ, Pulley D, Zhao Y, Bombardier J, Wallace S, Eckenrode J, Cudkowicz M, Dibernardo A. A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2010 Dec; 11(6):508-13. PMID: 20698808.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  58. Annamalai L, Bhaskar V, Pauley DR, Knight H, Williams K, Lentz M, Ratai E, Westmoreland SV, González RG, O'Neil SP. Impact of short-term combined antiretroviral therapy on brain virus burden in simian immunodeficiency virus-infected and CD8+ lymphocyte-depleted rhesus macaques. Am J Pathol. 2010 Aug; 177(2):777-91. PMID: 20595631; PMCID: PMC2913382.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  59. Ratai EM, Bombardier JP, Joo CG, Annamalai L, Burdo TH, Campbell J, Fell R, Hakimelahi R, He J, Autissier P, Lentz MR, Halpern EF, Masliah E, Williams KC, Westmoreland SV, González RG. Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS. PLoS One. 2010 May 07; 5(5):e10523. PMID: 20479889.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  60. Liu S, Fleysher R, Fleysher L, Joo CG, Ratai EM, González RG, Gonen O. Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T. Magn Reson Med. 2010 Apr; 63(4):865-71. PMID: 20373387.
    Citations: 4     Fields:    Translation:Animals
  61. Ramadan S, Ratai EM, Wald LL, Mountford CE. In vivo 1D and 2D correlation MR spectroscopy of the soleus muscle at 7T. J Magn Reson. 2010 May; 204(1):91-8. PMID: 20206561; PMCID: PMC3741347.
    Citations: 10     Fields:    Translation:Humans
  62. Andronesi OC, Ramadan S, Ratai EM, Jennings D, Mountford CE, Sorensen AG. Spectroscopic imaging with improved gradient modulated constant adiabaticity pulses on high-field clinical scanners. J Magn Reson. 2010 Apr; 203(2):283-93. PMID: 20163975.
    Citations: 41     Fields:    
  63. Wu CL, Jordan KW, Ratai EM, Sheng J, Adkins CB, Defeo EM, Jenkins BG, Ying L, McDougal WS, Cheng LL. Metabolomic imaging for human prostate cancer detection. Sci Transl Med. 2010 Jan 27; 2(16):16ra8. PMID: 20371475.
    Citations: 17     Fields:    Translation:Humans
  64. Liu S, Gonen O, Fleysher R, Fleysher L, Babb JS, Soher BJ, Joo CG, Ratai EM, González RG. Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T. Magn Reson Med. 2009 Nov; 62(5):1292-9. PMID: 19780178.
    Citations: 2     Fields:    Translation:Animals
  65. Ratai EM, Pilkenton SJ, Greco JB, Lentz MR, Bombardier JP, Turk KW, He J, Joo CG, Lee V, Westmoreland S, Halpern E, Lackner AA, González RG. In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain. BMC Neurosci. 2009 Jun 22; 10:63. PMID: 19545432.
    Citations: 29     Fields:    Translation:AnimalsCells
  66. Ratai EM, González RG. Magnetic Resonance Imaging of the Brain and Spine, edited by Scott W. Atlas. Magnetic Resonance Spectroscopy and the Biochemical Basis of Neurologic Disease. 2009.
  67. Ratai E, Kok T, Wiggins C, Wiggins G, Grant E, Gagoski B, O'Neill G, Adalsteinsson E, Eichler F. Seven-Tesla proton magnetic resonance spectroscopic imaging in adult X-linked adrenoleukodystrophy. Arch Neurol. 2008 Nov; 65(11):1488-94. PMID: 19001168; PMCID: PMC2829763.
    Citations: 11     Fields:    Translation:Humans
  68. Lentz MR, Lee V, Westmoreland SV, Ratai EM, Halpern EF, González RG. Factor analysis reveals differences in brain metabolism in macaques with SIV/AIDS and those with SIV-induced encephalitis. NMR Biomed. 2008 Oct; 21(8):878-87. PMID: 18574793.
    Citations: 13     Fields:    Translation:Animals
  69. Liu S, Gonen O, Fleysher L, Fleysher R, Soher BJ, Pilkenton S, Lentz MR, Ratai EM, González RG. Regional metabolite T2 in the healthy rhesus macaque brain at 7T. Magn Reson Med. 2008 May; 59(5):1165-9. PMID: 18429024.
    Citations: 5     Fields:    Translation:Animals
  70. Ratai EM, Hancu I, Blezek DJ, Turk KW, Halpern E, González RG. Automatic repositioning of MRSI voxels in longitudinal studies: impact on reproducibility of metabolite concentration measurements. J Magn Reson Imaging. 2008 May; 27(5):1188-93. PMID: 18425834.
    Citations: 8     Fields:    Translation:Humans
  71. Gonen O, Liu S, Goelman G, Ratai EM, Pilkenton S, Lentz MR, González RG. Proton MR spectroscopic imaging of rhesus macaque brain in vivo at 7T. Magn Reson Med. 2008 Apr; 59(4):692-9. PMID: 18302225.
    Citations: 3     Fields:    Translation:Animals
  72. Lentz MR, Westmoreland SV, Lee V, Ratai EM, Halpern EF, González RG. Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS. Magn Reson Med. 2008 Mar; 59(3):475-84. PMID: 18306400.
    Citations: 14     Fields:    Translation:AnimalsCells
  73. Singhal AB, Ratai E, Benner T, Vangel M, Lee V, Koroshetz WJ, Schaefer PW, Sorensen AG, Gonzalez RG. Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke. Stroke. 2007 Oct; 38(10):2851-4. PMID: 17761914.
    Citations: 33     Fields:    Translation:Humans
  74. González RG, Greco JB, He J, Lentz MR, O'Neil S, Pilkenton SJ, Ratai EM, Westmoreland S. New insights into the neuroimmunity of SIV infection by magnetic resonance spectroscopy. J Neuroimmune Pharmacol. 2006 Jun; 1(2):152-9. PMID: 18040781.
    Citations: 7     Fields:    Translation:AnimalsCells
  75. Williams K, Westmoreland S, Greco J, Ratai E, Lentz M, Kim WK, Fuller RA, Kim JP, Autissier P, Sehgal PK, Schinazi RF, Bischofberger N, Piatak M, Lifson JD, Masliah E, González RG. Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS. J Clin Invest. 2005 Sep; 115(9):2534-45. PMID: 16110325; PMCID: PMC1187930.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  76. Ratai EM, Pilkenton S, Lentz MR, Greco JB, Fuller RA, Kim JP, He J, Cheng LL, González RG. Comparisons of brain metabolites observed by HRMAS 1H NMR of intact tissue and solution 1H NMR of tissue extracts in SIV-infected macaques. NMR Biomed. 2005 Jun; 18(4):242-51. PMID: 15759297.
    Citations: 8     Fields:    Translation:Animals
  77. Kim JP, Lentz MR, Westmoreland SV, Greco JB, Ratai EM, Halpern E, Lackner AA, Masliah E, González RG. Relationships between astrogliosis and 1H MR spectroscopic measures of brain choline/creatine and myo-inositol/creatine in a primate model. AJNR Am J Neuroradiol. 2005 Apr; 26(4):752-9. PMID: 15814917.
    Citations: 22     Fields:    Translation:Animals
  78. Lentz MR, Kim JP, Westmoreland SV, Greco JB, Fuller RA, Ratai EM, He J, Sehgal PK, Halpern EF, Lackner AA, Masliah E, González RG. Quantitative neuropathologic correlates of changes in ratio of N-acetylaspartate to creatine in macaque brain. Radiology. 2005 May; 235(2):461-8. PMID: 15798152.
    Citations: 35     Fields:    Translation:AnimalsCells
  79. Greco JB, Westmoreland SV, Ratai EM, Lentz MR, Sakaie K, He J, Sehgal PK, Masliah E, Lackner AA, González RG. In vivo 1H MRS of brain injury and repair during acute SIV infection in the macaque model of neuroAIDS. Magn Reson Med. 2004 Jun; 51(6):1108-14. PMID: 15170829.
    Citations: 31     Fields:    Translation:AnimalsCells
  80. Fuller RA, Westmoreland SV, Ratai E, Greco JB, Kim JP, Lentz MR, He J, Sehgal PK, Masliah E, Halpern E, Lackner AA, González RG. A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS. BMC Neurosci. 2004 Mar 05; 5:10. PMID: 15070430.
    Citations: 29     Fields:    Translation:AnimalsCells
  81. Cramer C, Gao Y, Brunklaus S, Ratai E. Ion Dynamics in Mixed Alkali Borate Glasses. Zeitschrift für Physikalische Chemie. 2004; 218(12):1413-1428 .
  82. Cramer C, Brunklaus S, Ratai E, Gao Y. New mixed alkali effect in the ac conductivity of ion-conducting glasses. Phys Rev Lett. 2003 Dec 31; 91(26 Pt 1):266601. PMID: 14754075.
    Citations:    Fields:    
  83. Ratai E, Augustine MP, Kauzlarich SM. Synthesis and Characterization of the Mg2SixGe1-x Solid Solution. J. Phys. Chem. B. 2003; 107(46):12573-12577.
  84. Ratai E.-M.; Janssen M.; Epping J.D.; Chan J.C.C.; Eckert H. . Local and medium range order in alkali borate glasses: an overview of recent solid state NMR results. Physics and Chemistry of Glasses. 2003; 44(2):45-53.
  85. Baldwin RK, Pettigrew KA, Ratai E, Augustine MP, Kauzlarich SM. Solution reduction synthesis of surface stabilized silicon nanoparticles. Chem Commun (Camb). 2002 Sep 07; (17):1822-3. PMID: 12271626.
    Citations: 8     Fields:    
  86. Ratai E, Chan JCC, Eckert H. Local Coordination and spatial distribution of cations in mixed-alkali borate glasses. Physical Chemistry Chemical Physics. 2002; 4(14):3198-3208.
  87. Ratai E, Bruins P, Hernandez CJ, Kauzlarich SM, and Augustine MP. Magnetic Resonance Study of a Series of Phosphorus-Containing Zintl Compounds: Ca14AlP11, Ca14MnP11, and Eu14MnP11. Chemistry of Materials. 2002; 14(6):2467-2475.
  88. Schoo U, Cramer C, Ratai E, Mehrer H. Diffusion in single and mixed-alkali borate glasses. Diffusion in single and mixed-alkali borate glasses. Diffusion in single and mixed-alkali borate glasses. 2001; 194-199:925-933.
  89. Ratai E, Janssen M, Eckert H. Solid State Ionics. Spatial distributions and chemical environments of cations in single- and mixed alkali borate glasses: evidence from solid state NMR. 1998; 105(1-4):25-37.
  90. Kanert O, Kuchler R, Peters J, Volmari A, Jain H, Eckert H, Ratai E. Journal of Non-Crystalline Solids. Structural basis of low-frequency excitations in silicophosphate glasses. 1997; 222:321-328.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.