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Vesela Kovacheva, Ph.D., M.D.

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Biography
Boston University, Boston, MAPhD09/2007Pathology and Neuroscience

Overview

Mentoring
Available: 01/01/00, Expires: 12/03/23

HARNESSING THE POWER OF ARTIFICIAL INTELLIGENCE TO IMPROVE SURGICAL AND PREGNANCY OUTCOMES We are working on developing the first in human artificial intelligence-powered algorithms to transform the care for pregnant women at risk for adverse pregnancy outcomes. There are multiple events around the time of delivery that can affect the maternal and fetal outcome and experiences. We use various transparent machine learning techniques to predict and prevent severe maternal morbidity, detect racial bias, and improve patient safety. Our lab is a welcoming and an inclusive environment, and we have a great experience with HMS students. We are looking for a motivated and self-directed team player who is interested in obstetrics, anesthesia, and clinical/translational research. The job involves interacting with patients and providers as well as accessing medical records to collect clinical data and basic data analysis. No prior experience is necessary; this job is suitable for any medical student level. The student will have the opportunity to get experience with research design, IRB application, review, and statistics. If the candidate has experience with computer science/Python/ PostgreSQL, we can offer some additional experience in data science and machine learning. There are opportunities for remote work and in-person clinical research work, depending on the candidate's schedule. We anticipate a minimum commitment of 15 hours per week for at least 12 weeks.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Scoon LEG, Gray KJ, Zhou G, Cohen RY, Armero W, Chen YK, Ray AM, Diouf K, Goldfarb IT, Boatin AA, Kovacheva VP. Hemodynamic changes in patients with SARS-CoV-2 infection presenting for cesarean delivery under spinal anesthesia: a retrospective case-control study. Int J Obstet Anesth. 2022 Dec 28; 53:103624. PMID: 36634448; PMCID: PMC9795802.
    Citations:    Fields:    
  2. Armero W, Gray KJ, Fields KG, Cole NM, Bates DW, Kovacheva VP. A survey of pregnant patients' perspectives on the implementation of artificial intelligence in clinical care. J Am Med Inform Assoc. 2022 Dec 13; 30(1):46-53. PMID: 36250788; PMCID: PMC9748543.
    Citations:    Fields:    Translation:Humans
  3. Wilson JM, He J, Flowers KM, Kovacheva V, Soens M, Schreiber KL. Pain Severity and Pain Interference in Late Pregnancy: An Analysis of Biopsychosocial Factors among Women Scheduled for Cesarean Delivery. Pain Med. 2022 Nov 04. PMID: 36331346.
    Citations:    Fields:    
  4. Mukasa CDM, Kovacheva VP. Development and implementation of databases to track patient and safety outcomes. Curr Opin Anaesthesiol. 2022 Dec 01; 35(6):710-716. PMID: 36302209.
    Citations:    Fields:    Translation:Humans
  5. Chen YK, Soens MA, Kovacheva VP. Less stress, better success: a scoping review on the effects of anxiety on anesthetic and analgesic consumption. J Anesth. 2022 08; 36(4):532-553. PMID: 35779126.
    Citations:    Fields:    
  6. Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, Wilson ML, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Risk of pre-eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case-control study. BJOG. 2021 01; 128(1):55-65. PMID: 32741103.
    Citations: 4     Fields:    Translation:Humans
  7. Kovacheva VP, Brovman EY, Greenberg P, Song E, Palanisamy A, Urman RD. A Contemporary Analysis of Medicolegal Issues in Obstetric Anesthesia Between 2005 and 2015. Anesth Analg. 2019 06; 128(6):1199-1207. PMID: 31094788.
    Citations: 1     Fields:    Translation:Humans
  8. Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, DeWan AT, Triche EW, Saftlas AF, Hoh J, Bodian DL, Klein E, Huddleston KC, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Wilson ML, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1. Hypertension. 2018 08; 72(2):408-416. PMID: 29967039.
    Citations: 20     Fields:    Translation:Humans
  9. Kovacheva VP, Brovman EY, Greenberg P, Song E, Palanisamy A, Urman RD. A Contemporary Analysis of Medicolegal Issues in Obstetric Anesthesia Between 2005 and 2015. Anesth Analg. 2018 May 10. PMID: 29757778.
    Citations:    Fields:    
  10. Kovacheva VP, Tsen LC. Predictors of Achieving Recommended Daily Physical Activity Among Anesthesiologists at a Large Tertiary Care Academic Center. J Clin Med Res. 2018 Jan; 10(1):50-55. PMID: 29238434; PMCID: PMC5722045.
    Citations: 2     
  11. Kovacheva VP, Aglio LS, Boland TA, Mendu ML, Gibbons FK, Christopher KB. Acute Kidney Injury After Craniotomy Is Associated With Increased Mortality: A Cohort Study. Neurosurgery. 2016 Sep; 79(3):389-96. PMID: 26645967.
    Citations: 2     Fields:    Translation:Humans
  12. Kovacheva VP, Soens MA, Tsen LC. A Randomized, Double-blinded Trial of a "Rule of Threes" Algorithm versus Continuous Infusion of Oxytocin during Elective Cesarean Delivery. Anesthesiology. 2015 Jul; 123(1):92-100. PMID: 25909969.
    Citations: 11     Fields:    Translation:Humans
  13. Kovacheva VP, Soens MA, Tsen LC. Serum uric acid as a novel marker for uterine atony and post-spinal vasopressor use during cesarean delivery. Int J Obstet Anesth. 2013 Jul; 22(3):200-8. PMID: 23702182.
    Citations:    Fields:    Translation:Humans
  14. Kovacheva VP, Davison JM, Mellott TJ, Rogers AE, Yang S, O'Brien MJ, Blusztajn JK. Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. FASEB J. 2009 Apr; 23(4):1054-63. PMID: 19047067.
    Citations: 14     Fields:    Translation:Animals
  15. Davison JM, Mellott TJ, Kovacheva VP, Blusztajn JK. Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. J Biol Chem. 2009 Jan 23; 284(4):1982-9. PMID: 19001366.
    Citations: 64     Fields:    Translation:AnimalsCells
  16. Kovacheva VP, Mellott TJ, Davison JM, Wagner N, Lopez-Coviella I, Schnitzler AC, Blusztajn JK. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J Biol Chem. 2007 Oct 26; 282(43):31777-88. PMID: 17724018.
    Citations: 99     Fields:    Translation:AnimalsCells
  17. Lopez-Coviella I, Mellott TM, Kovacheva VP, Berse B, Slack BE, Zemelko V, Schnitzler A, Blusztajn JK. Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain. Brain Res. 2006 May 09; 1088(1):49-56. PMID: 16626664.
    Citations: 15     Fields:    Translation:AnimalsCells
  18. Lopez-Coviella I, Follettie MT, Mellott TJ, Kovacheva VP, Slack BE, Diesl V, Berse B, Thies RS, Blusztajn JK. Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6984-9. PMID: 15870197; PMCID: PMC1088172.
    Citations: 32     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.