Harvard Catalyst Profiles

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Igor V. Garkavtsev, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21CA169616 (GARKAVTSEV, IGOR) Feb 7, 2013 - Jan 31, 2015
    Evaluation of TNBC treatment strategy utilizing novel signaling pathways
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Munn LL, Garkavtsev I. SLPI: a new target for stopping metastasis. Aging (Albany NY). 2018 Jan 20; 10(1):13-14. PMID: 29356683.
    Citations:    Fields:    
  2. Kozin SV, Maimon N, Wang R, Gupta N, Munn L, Jain RK, Garkavtsev I. Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers. Oncotarget. 2017 Dec 12; 8(65):108292-108302. PMID: 29312532.
    Citations: 1     Fields:    
  3. Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK, Garkavtsev I. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1033-1038. PMID: 28096337.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Han S, Ma X, Zhao Y, Zhao H, Batista A, Zhou S, Zhou X, Yang Y, Wang T, Bi J, Xia Z, Bai Z, Garkavtsev I, Zhang Z. Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer. Oncotarget. 2016 Jul 12; 7(28):44406-44416. PMID: 27259271.
    Citations: 2     Fields:    Translation:Humans
  5. Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK. Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism. Neoplasia. 2012 Feb; 14(2):84-94. PMID: 22431917.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  6. Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson RT, Jain RK. Dehydro-alpha-lapachone, a plant product with antivascular activity. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11596-601. PMID: 21709229.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  7. Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y. Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors. Cancer Res. 2011 Jul 01; 71(13):4527-38. PMID: 21571860.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  8. Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK. Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells. Neoplasia. 2007 Dec; 9(12):1038-45. PMID: 18084611.
    Citations: 14     Fields:    Translation:HumansCells
  9. Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y. Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors. Cancer Res. 2007 Jun 01; 67(11):5076-82. PMID: 17545583.
    Citations: 12     Fields:    Translation:HumansAnimals
  10. Garkavtsev I, Boucher Y. An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol. . 2005 Jan; 4(1):48-9. PMID: 15711122.
    Citations: 5     Fields:    Translation:HumansCells
  11. Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 2004 Dec; 6(6):553-63. PMID: 15607960.
    Citations: 383     Fields:    Translation:HumansAnimalsCells
  12. Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature. 2004 Mar 18; 428(6980):328-32. PMID: 15029197.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  13. Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ Res. 2003 Oct 31; 93(9):e88-97. PMID: 14525808.
    Citations: 76     Fields:    Translation:AnimalsCells
  14. Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N. A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). FEBS Lett. 2002 Jul 31; 524(1-3):163-71. PMID: 12135761.
    Citations: 10     Fields:    Translation:HumansCells
  15. Garkavtsev IV, Kley N, Grigorian IA, Gudkov AV. The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control. Oncogene. 2001 Dec 13; 20(57):8276-80. PMID: 11781842.
    Citations: 7     Fields:    Translation:HumansCells
  16. Tatusov RL, Natale DA, Garkavtsev IV, Tatusova TA, Shankavaram UT, Rao BS, Kiryutin B, Galperin MY, Fedorova ND, Koonin EV. The COG database: new developments in phylogenetic classification of proteins from complete genomes. Nucleic Acids Res. 2001 Jan 01; 29(1):22-8. PMID: 11125040.
    Citations: 631     Fields:    Translation:AnimalsCells
  17. Zeremski M, Hill JE, Kwek SS, Grigorian IA, Gurova KV, Garkavtsev IV, Diatchenko L, Koonin EV, Gudkov AV. Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function. J Biol Chem. 1999 Nov 05; 274(45):32172-81. PMID: 10542254.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  18. Garkavtsev IV, Tsvetkova TG, Yegolina NA, Gudkov AV. Variability of human rRNA genes: inheritance and nonrandom chromosomal distribution of structural variants of nontranscribed spacer sequences. Hum Genet. 1988 Dec; 81(1):31-7. PMID: 3198124.
    Citations: 1     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.