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Elena Aikawa, PH.D., M.D.

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Mentoring
Novel Mechanism of Atherosclerotic Plaque Rupture: Zooming in on the Genesis of Microcalcifications
Summer, 06/26/14 - 08/29/14

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL147095 (AIKAWA, ELENA) Apr 1, 2019 - Mar 31, 2023
    NIH/NHLBI
    New driver of fibrosis and calcification in CAVD
    Role: Principal Investigator
  2. R01HL141917 (LEVINE, ROBERT A) Apr 1, 2018 - Mar 31, 2022
    NIH/NHLBI
    Improving Mitral Compensation In Ischemic Regurgitation
    Role: Co-Principal Investigator
  3. R01HL136431 (AIKAWA, ELENA) Mar 24, 2017 - Feb 28, 2021
    NIH/NHLBI
    Macrophage-derived microcalcificaitons
    Role: Principal Investigator
  4. R01HL114805 (AIKAWA, ELENA) Aug 23, 2012 - Jun 30, 2017
    NIH/NHLBI
    Aortic valve microcalcification
    Role: Principal Investigator
  5. R01HL109506 (LEVINE, ROBERT A) May 15, 2012 - Apr 30, 2016
    NIH/NHLBI
    Improving Mitral Compensation in Ischemic Regurgitation
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR. Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis. J Am Coll Cardiol. 2019 May 07; 73(17):2150-2162. PMID: 31047003.
    Citations:    
  2. Rogers MA, Aikawa E. Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery. Nat Rev Cardiol. 2019 May; 16(5):261-274. PMID: 30531869.
    Citations:    Fields:    
  3. Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E. Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification. Front Cardiovasc Med. 2019; 6:49. PMID: 31041314.
    Citations:    
  4. Phillippi JA, Aikawa E, Hutcheson J. Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine. Front Cardiovasc Med. 2019; 6:13. PMID: 30873414.
    Citations:    
  5. Blaser MC, Aikawa E. Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis. Circ Res. 2019 Feb 15; 124(4):467-469. PMID: 30763209.
    Citations:    
  6. Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR. After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology. Front Cardiovasc Med. 2019; 6:8. PMID: 30838213.
    Citations:    
  7. Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH. Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019 Jan 22; 73(2):190-209. PMID: 30654892.
    Citations:    Fields:    
  8. Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabási AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M. Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling. Circulation. 2019 Jan 02; 139(1):78-96. PMID: 30586693.
    Citations:    Fields:    
  9. Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E. 18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images. Circ Cardiovasc Imaging. 2019 Jan; 12(1):e007835. PMID: 30642216.
    Citations:    Fields:    
  10. Blaser MC, Aikawa E. Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism. Front Cardiovasc Med. 2018; 5:187. PMID: 30622949.
    Citations:    
  11. Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanovic MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Line A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BW, van der Grein SG, Van Deun J, van Herwijnen MJ, Van Keuren-Jensen K, van Niel G, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018; 7(1):1535750. PMID: 30637094.
    Citations:    
  12. Koenen RR, Aikawa E. Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases. Front Cardiovasc Med. 2018; 5:133. PMID: 30283791.
    Citations:    
  13. Dekker S, van Geemen D, van den Bogaerdt AJ, Driessen-Mol A, Aikawa E, Smits AIPM. Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves. Front Cardiovasc Med. 2018; 5:105. PMID: 30159315.
    Citations:    
  14. Gottlieb Sen D, Halu A, Razzaque A, Gorham JM, Hartnett J, Seidman JG, Aikawa E, Seidman CE. The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development. Ann Thorac Surg. 2018 Dec; 106(6):1834-1840. PMID: 30071238.
    Citations:    Fields:    
  15. Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E. Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease. Circulation. 2018 Jul 24; 138(4):377-393. PMID: 29588317.
    Citations:    Fields:    
  16. Peeters FECM, Meex SJR, Dweck MR, Aikawa E, Crijns HJGM, Schurgers LJ, Kietselaer BLJH. Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment. Eur Heart J. 2018 Jul 21; 39(28):2618-2624. PMID: 29136138.
    Citations: 3     Fields:    
  17. Hagita S, Rogers MA, Pham T, Wen JR, Mlynarchik AK, Aikawa M, Aikawa E. Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin. Sci Rep. 2018 Jun 13; 8(1):9006. PMID: 29899496.
    Citations:    Fields:    
  18. van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E. Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. Nanomaterials (Basel). 2018 May 03; 8(5). PMID: 29751516.
    Citations:    
  19. Hutcheson JD, Aikawa E. Extracellular vesicles in cardiovascular homeostasis and disease. Curr Opin Cardiol. 2018 05; 33(3):290-297. PMID: 29465447.
    Citations: 1     Fields:    
  20. Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ. New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study. Eur Heart J. 2018 Apr 14; 39(15):1269-1277. PMID: 29020406.
    Citations: 1     Fields:    
  21. Kim DH, Dal-Bianco JP, Aikawa E, Bischoff J, Levine RA. Mitral Valve Adaptation: Can We Win the Race? Circ Cardiovasc Imaging. 2018 Apr; 11(4):e007642. PMID: 29626080.
    Citations:    Fields:    
  22. Hoganson DM, Cooper DA, Rich KN, Piekarski BL, Gui L, Gaut JP, Mayer JE, Aikawa E, Niklason LE, Emani SM. Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction. Ann Thorac Surg. 2018 06; 105(6):1809-1818. PMID: 29510094.
    Citations:    Fields:    
  23. Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. Int J Mol Sci. 2018 Feb 27; 19(3). PMID: 29495441.
    Citations: 1     Fields:    Translation:HumansCells
  24. Itoh S, Mizuno K, Aikawa M, Aikawa E. Dimerization of sortilin regulates its trafficking to extracellular vesicles. J Biol Chem. 2018 03 23; 293(12):4532-4544. PMID: 29382723.
    Citations: 1     Fields:    Translation:HumansCells
  25. Sena BF, Figueiredo JL, Aikawa E. Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease. Front Cardiovasc Med. 2017; 4:88. PMID: 29379789.
    Citations: 1     
  26. Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK. Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation. JACC Cardiovasc Imaging. 2019 Apr; 12(4):665-677. PMID: 29248661.
    Citations: 1     Fields:    
  27. Bakhshian Nik A, Hutcheson JD, Aikawa E. Extracellular Vesicles As Mediators of Cardiovascular Calcification. Front Cardiovasc Med. 2017; 4:78. PMID: 29322046.
    Citations: 3     
  28. Goettsch C, Kjolby M, Aikawa E. Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):19-25. PMID: 29191923.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  29. Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA. Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling. Circ Cardiovasc Imaging. 2017 Nov; 10(11). PMID: 29042413.
    Citations: 1     Fields:    Translation:HumansAnimals
  30. Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA. Effect of Losartan on Mitral Valve Changes After Myocardial Infarction. J Am Coll Cardiol. 2017 Sep 05; 70(10):1232-1244. PMID: 28859786.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  31. Rogers MA, Aikawa M, Aikawa E. Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues. Circ Res. 2017 06 23; 121(1):5-7. PMID: 28642321.
    Citations:    Fields:    
  32. Rogers MA, Maldonado N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E. Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Circ Res. 2017 Jul 21; 121(3):220-233. PMID: 28607103.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  33. Aikawa E, Libby P. A Rock and a Hard Place: Chiseling Away at the Multiple Mechanisms of Aortic Stenosis. Circulation. 2017 05 16; 135(20):1951-1955. PMID: 28507250.
    Citations: 3     Fields:    Translation:Humans
  34. Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P. Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion. Circ Res. 2017 Jun 23; 121(1):31-42. PMID: 28428204.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  35. Nagy E, Lei Y, Martínez-Martínez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E. Interferon-? Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves. Am J Pathol. 2017 Jun; 187(6):1413-1425. PMID: 28431214.
    Citations: 2     Fields:    Translation:HumansCells
  36. Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E. Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. Arterioscler Thromb Vasc Biol. 2017 05; 37(5):1005-1011. PMID: 28279970.
    Citations:    Fields:    Translation:HumansCells
  37. van der Ven CF, Wu PJ, Tibbitt MW, van Mil A, Sluijter JP, Langer R, Aikawa E. In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease. Clin Sci (Lond). 2017 02 01; 131(3):181-195. PMID: 28057890.
    Citations: 2     Fields:    Translation:HumansAnimals
  38. Hutcheson JD, Blaser MC, Aikawa E. Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field. Circ Res. 2017 01 20; 120(2):270-273. PMID: 28104767.
    Citations: 4     Fields:    Translation:HumansAnimals
  39. Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E. Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development. Front Cardiovasc Med. 2016; 3:44. PMID: 27867942.
    Citations:    
  40. Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Nat Commun. 2016 10 31; 7:12849. PMID: 27796300.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  41. Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko PE, Guerrero JL, Dal-Bianco JP, Beaudoin J, Garcia ML, Sullivan SM, Seybolt MM, Morris BA, Keegan J, Irvin WS, Aikawa E, Levine RA. CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction. Circ Res. 2016 Nov 11; 119(11):1215-1225. PMID: 27750208.
    Citations: 8     Fields:    Translation:AnimalsCells
  42. Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD. Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease. Cell Stem Cell. 2016 11 03; 19(5):628-642. PMID: 27618218.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  43. Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E. Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency. Semin Thorac Cardiovasc Surg. 2016 Winter; 28(4):757-767. PMID: 28417861.
    Citations:    Fields:    Translation:HumansCells
  44. Singh SA, Aikawa E, Aikawa M. Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research. Circ J. 2016 Jul 25; 80(8):1674-83. PMID: 27430298.
    Citations: 1     Fields:    Translation:HumansAnimals
  45. Dweck MR, Aikawa E, Newby DE, Tarkin JM, Rudd JH, Narula J, Fayad ZA. Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis. Circ Res. 2016 07 08; 119(2):330-40. PMID: 27390335.
    Citations: 16     Fields:    Translation:Humans
  46. Mosch J, Gleissner CA, Body S, Aikawa E. Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus. Histol Histopathol. 2017 Mar; 32(3):293-306. PMID: 27353274.
    Citations: 3     Fields:    Translation:Humans
  47. Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E. A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. Atherosclerosis. 2016 08; 251:109-118. PMID: 27318830.
    Citations: 6     Fields:    Translation:AnimalsCells
  48. Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E. Extracellular vesicles in cardiovascular calcification: expanding current paradigms. J Physiol. 2016 06 01; 594(11):2895-903. PMID: 26824781.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  49. Aikawa E. Extracellular vesicles in cardiovascular disease: focus on vascular calcification. J Physiol. 2016 06 01; 594(11):2877-80. PMID: 27246548.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  50. O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R. Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation. J Vis Exp. 2016 05 31; (111). PMID: 27284788.
    Citations: 1     Fields:    Translation:HumansAnimals
  51. Ruiz JL, Weinbaum S, Aikawa E, Hutcheson JD. Zooming in on the genesis of atherosclerotic plaque microcalcifications. J Physiol. 2016 06 01; 594(11):2915-27. PMID: 27040360.
    Citations: 3     Fields:    Translation:HumansAnimals
  52. Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E. Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation. J Mol Cell Cardiol. 2016 05; 94:13-20. PMID: 26996755.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  53. Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA. 3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR. Eur Heart J Cardiovasc Imaging. 2016 May; 17(5):510-1. PMID: 26976355.
    Citations:    Fields:    Translation:Humans
  54. Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016 Apr 01; 126(4):1323-36. PMID: 26950419.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  55. Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA. Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve. J Am Coll Cardiol. 2016 Jan 26; 67(3):275-87. PMID: 26796392.
    Citations: 10     Fields:    Translation:Animals
  56. Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E. Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-ß Signaling. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):525-33. PMID: 26800565.
    Citations: 8     Fields:    Translation:AnimalsCells
  57. Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E. Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nat Mater. 2016 Mar; 15(3):335-43. PMID: 26752654.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  58. Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH. Mitral valve disease--morphology and mechanisms. Nat Rev Cardiol. 2015 Dec; 12(12):689-710. PMID: 26483167.
    Citations: 24     Fields:    Translation:Humans
  59. Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga J, Sonoki H, Matsumoto J, Aikawa M, Aikawa E. Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease. PLoS One. 2015; 10(9):e0138047. PMID: 26367531.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  60. Hutcheson JD, Goettsch C, Rogers MA, Aikawa E. Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach. Semin Cell Dev Biol. 2015 Oct; 46:68-77. PMID: 26358815.
    Citations: 4     Fields:    Translation:HumansAnimals
  61. Rogers MA, Aikawa E. A Not-So-Little Role for Lipoprotein(a) in the Development of Calcific Aortic Valve Disease. Circulation. 2015 Aug 25; 132(8):621-3. PMID: 26224809.
    Citations: 2     Fields:    Translation:HumansAnimals
  62. Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E. Valvular interstitial cells suppress calcification of valvular endothelial cells. Atherosclerosis. 2015 Sep; 242(1):251-260. PMID: 26232165.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  63. Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E. N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification. J Cardiovasc Dev Dis. 2015 Apr 15; 2(2):31-47. PMID: 29371511.
    Citations:    
  64. Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E. N-acetylglucosamine-1-Pthosphate transferase Suppresses Lysosamal Hydrolases in Dysphunctional Osteoclasts: A Potential Mechanism for Vascular Calcification. Journal of Cardiovascular Development and Disease. 2015; (2):31-47.
  65. Ruiz JL, Hutcheson JD, Aikawa E. Cardiovascular calcification: current controversies and novel concepts. Cardiovasc Pathol. 2015 Jul-Aug; 24(4):207-12. PMID: 25797772.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  66. Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W, Hartmann G, Aikawa E. Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease. Am J Pathol. 2015 Apr; 185(4):1156-66. PMID: 25680278.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  67. Hutcheson JD, Aikawa E. Cardiovascular imaging: Arterial and aortic valve inflammation and calcification. Ed. Aikawa E. Pathobiology and optical molecular imaging of calcific aortic valve disease. 2014; pp. 187-201.
  68. Hutcheson JD, Aikawa E. Cardiovascular imaging: Arterial and aortic valve inflammation and calcification. Ed. Aikawa E. Optical molecular imaging of inflammation and calcification in atherosclerosis. 2014; pp.107-121.
  69. Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E. Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol. J Extracell Vesicles. 2014; 3:25129. PMID: 25491249.
    Citations: 10     
  70. Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stepien E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics. 2015 Mar 15; 31(6):933-9. PMID: 25388151.
    Citations: 54     Fields:    Translation:HumansCells
  71. Hutcheson JD, Maldonado N, Aikawa E. Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability. Curr Opin Lipidol. 2014 Oct; 25(5):327-32. PMID: 25188916.
    Citations: 19     Fields:    Translation:Humans
  72. Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2014 Nov; 34(11):2387-93. PMID: 25189570.
    Citations: 31     Fields:    Translation:HumansCells
  73. Goettsch C, Iwata H, Aikawa E. Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1333-5. PMID: 24951650.
    Citations: 5     Fields:    Translation:Humans
  74. Hjortnaes J, Camci-Unal G, Hutcheson JD, Jung SM, Schoen FJ, Kluin J, Aikawa E, Khademhosseini A. Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform. Adv Healthc Mater. 2015 Jan 07; 4(1):121-30. PMID: 24958085.
    Citations: 7     Fields:    Translation:AnimalsCells
  75. Rogers MA, Aikawa E. Modifying vascular calcification in diabetes mellitus: contribution of O-GlcNAcylation. Circ Res. 2014 Mar 28; 114(7):1074-6. PMID: 24677232.
    Citations: 2     Fields:    Translation:Animals
  76. Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E. A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program. PLoS One. 2014; 9(3):e89627. PMID: 24595280.
    Citations: 3     Fields:    
  77. Hutcheson JD, Aikawa E, Merryman WD. Potential drug targets for calcific aortic valve disease. Nat Rev Cardiol. 2014 Apr; 11(4):218-31. PMID: 24445487.
    Citations: 17     Fields:    Translation:Humans
  78. Martinez Martinez E, Aikawa E. Molecular biology of valvular heart disease. Ed. Rajamannan NM. Identification of early pathological events in calcific aortic valve decease by molecular imaging. 2014; 107-117.
  79. Aikawa E, Schoen FJ. Calcific and degenerative heart valve disease. Cellular and molecular pathobiology of cardiovascular disease. Ed. Willis MS, Homeister JW, Stone JR. Elsevier. 2014.
  80. Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E. Cystathionine ?-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):626-34. PMID: 24357058.
    Citations: 8     Fields:    Translation:AnimalsCells
  81. Aikawa E, Gardiner C, Hutcheson JD, Ochiya T, Osteikoetxea X, Pegtel M, Piper M, Quesenberry P, Schiffelers RM, Szabó TG, Buzas EI. International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013). J Extracell Vesicles. 2013; 2:23070. PMID: 26082318.
    Citations:    
  82. Rogers M, Goettsch C, Aikawa E. Medial and intimal calcification in chronic kidney disease: stressing the contributions. J Am Heart Assoc. 2013 Sep 23; 2(5):e000481. PMID: 24060959.
    Citations: 6     Fields:    Translation:Animals
  83. New SE, Aikawa E. Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1753-8. PMID: 23766262.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  84. Kelly-Arnold A, Maldonado N, Laudier D, Aikawa E, Cardoso L, Weinbaum S. Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10741-6. PMID: 23733926.
    Citations: 50     Fields:    Translation:Humans
  85. Wang JG, Aikawa E, Aikawa M. Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis. J Am Coll Cardiol. 2013 Oct 15; 62(16):1442-5. PMID: 23707315.
    Citations: 3     Fields:    Translation:HumansCells
  86. Votteler M, Berrio DA, Horke A, Sabatier L, Reinhardt DP, Nsair A, Aikawa E, Schenke-Layland K. Elastogenesis at the onset of human cardiac valve development. Development. 2013 Jun; 140(11):2345-53. PMID: 23637335.
    Citations: 9     Fields:    Translation:Humans
  87. New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E. Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques. Circ Res. 2013 Jun 21; 113(1):72-7. PMID: 23616621.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  88. Goettsch C, Hutcheson JD, Aikawa E. MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms. Circ Res. 2013 Mar 29; 112(7):1073-84. PMID: 23538277.
    Citations: 21     Fields:    Translation:HumansAnimals
  89. Abe J, Manabe I, Aikawa M, Aikawa E. Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation. Int J Inflam. 2013; 2013:953463. PMID: 23555068.
    Citations: 2     
  90. Hjortnaes J, New SE, Aikawa E. Visualizing novel concepts of cardiovascular calcification. Trends Cardiovasc Med. 2013 Apr; 23(3):71-9. PMID: 23290463.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  91. Goettsch C, Aikawa E. Role of microRNAs in Cardiovascular Calcification. In: Calcific Aortic Valve Disease. Aikawa E (ed). InTech, pp 123-149. 2013.
  92. Aikawa E, Gardiner C, Hutcheson JD, Ochiya T, Osteikoetxea X, Pegtel M, Piper M, Quesenberry P, Schiffelers RM, Szabo TG, Buzas EI. JEV. International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April, 2013, Boston, MA (ISEV 2013). 2013; (2):1-19.
  93. Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 2012; 10(12):e1001450. PMID: 23271954.
    Citations: 227     Fields:    Translation:Cells
  94. Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M. Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion. Eur Heart J. 2013 Feb; 34(8):615-24. PMID: 22927557.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  95. Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):E1868-77. PMID: 22699504.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  96. Aikawa M, Manabe I, Chester A, Aikawa E. Cardiovascular inflammation. Int J Inflam. 2012; 2012:904608. PMID: 22518345.
    Citations: 1     
  97. Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3):613-22. PMID: 22223731.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  98. Aikawa E, Grande-Allen KJ. Biology of Mitral valve Disease. In: Cardiac Valvular Medicine. Rajamannan NM (ed). Springer-Verlag, London, pp.173-187. 2012.
  99. Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):19943-8. PMID: 22123981.
    Citations: 37     Fields:    Translation:AnimalsCells
  100. Aikawa E, Otto CM. Look more closely at the valve: imaging calcific aortic valve disease. Circulation. 2012 Jan 03; 125(1):9-11. PMID: 22090164.
    Citations: 12     Fields:    Translation:Humans
  101. Su HS, Nahrendorf M, Panizzi P, Breckwoldt MO, Rodriguez E, Iwamoto Y, Aikawa E, Weissleder R, Chen JW. Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase. Radiology. 2012 Jan; 262(1):181-90. PMID: 22084204.
    Citations: 3     Fields:    Translation:Animals
  102. Quillard T, Tesmenitsky Y, Croce K, Travers R, Shvartz E, Koskinas KC, Sukhova GK, Aikawa E, Aikawa M, Libby P. Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2464-72. PMID: 21903941.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  103. Goettsch C, Rauner M, Sinningen K, Helas S, Al-Fakhri N, Nemeth K, Hamann C, Kopprasch S, Aikawa E, Bornstein SR, Schoppet M, Hofbauer LC. The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells. Endocrinology. 2011 Dec; 152(12):4915-26. PMID: 22009730.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  104. Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation. 2011 Oct 18; 124(16):1783-91. PMID: 22007101.
    Citations: 151     Fields:    Translation:Humans
  105. Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R. In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nat Med. 2011 Aug 21; 17(9):1142-6. PMID: 21857652.
    Citations: 36     Fields:    Translation:AnimalsCells
  106. Bischoff J, Aikawa E. Progenitor cells confer plasticity to cardiac valve endothelium. J Cardiovasc Transl Res. 2011 Dec; 4(6):710-9. PMID: 21789724.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  107. New SE, Aikawa E. Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification. Circ Res. 2011 May 27; 108(11):1381-91. PMID: 21617135.
    Citations: 69     Fields:    Translation:Humans
  108. Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y, Folco EJ, Ntziachristos V, Weissleder R, Libby P, Jaffer FA. Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques. Sci Transl Med. 2011 May 25; 3(84):84ra45. PMID: 21613624.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  109. New SE, Aikawa E. Cardiovascular calcification: an inflammatory disease. Circ J. 2011; 75(6):1305-13. PMID: 21566338.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  110. Brokopp CE, Schoenauer R, Richards P, Bauer S, Lohmann C, Emmert MY, Weber B, Winnik S, Aikawa E, Graves K, Genoni M, Vogt P, Lüscher TF, Renner C, Hoerstrup SP, Matter CM. Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata. Eur Heart J. 2011 Nov; 32(21):2713-22. PMID: 21292680.
    Citations: 24     Fields:    Translation:HumansCells
  111. Aikawa E. In Ducheyne P, Healy KE, Hutmacher DW, Grainer CJ (eds). Comprehensive Biomaterials. Elsevier. Immunohistochemistry. 2011; 277-290.
  112. Hjortnaes J, Aikawa E. . Calcific Aortic Valve Disease. I: Aortic Valve. Chen YF, Luo CY (eds). InTech. 133-162. 2011.
  113. Wylie-Sears J, Aikawa E, Levine RA, Yang JH, Bischoff J. Mitral valve endothelial cells with osteogenic differentiation potential. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):598-607. PMID: 21164078.
    Citations: 38     Fields:    Translation:AnimalsCells
  114. Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FA. Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):1933-9. PMID: 20689078.
    Citations: 22     Fields:    Translation:AnimalsCells
  115. Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer JE, Aikawa E. Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study. Tissue Eng Part C Methods. 2010 Aug; 16(4):597-607. PMID: 19751103.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  116. Hjortnaes J, Butcher J, Figueiredo JL, Riccio M, Kohler RH, Kozloff KM, Weissleder R, Aikawa E. Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. Eur Heart J. 2010 Aug; 31(16):1975-84. PMID: 20601388.
    Citations: 51     Fields:    Translation:Animals
  117. Norris RA, Moreno-Rodriguez R, Wessels A, Merot J, Bruneval P, Chester AH, Yacoub MH, Hagège A, Slaugenhaupt SA, Aikawa E, Schott JJ, Lardeux A, Harris BS, Williams LK, Richards A, Levine RA, Markwald RR. Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis. Dev Dyn. 2010 Jul; 239(7):2118-27. PMID: 20549728.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  118. Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M. Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol. 2010 Apr 13; 55(15):1629-38. PMID: 20378083.
    Citations: 95     Fields:    Translation:AnimalsCells
  119. Gottlieb D, Kunal T, Emani S, Aikawa E, Brown DW, Powell AJ, Nedder A, Engelmayr GC, Melero-Martin JM, Sacks MS, Mayer JE. In vivo monitoring of function of autologous engineered pulmonary valve. J Thorac Cardiovasc Surg. 2010 Mar; 139(3):723-31. PMID: 20176213.
    Citations: 21     Fields:    Translation:Animals
  120. Aikawa, Elena. Current Cardiovascular Imaging Reports. Optical Molecular Imaging of Inflammation and Calcification in Atherosclerosis. 2010; 3(1):12-17. View Publication.
  121. Sales VL, Mettler BA, Engelmayr GC, Aikawa E, Bischoff J, Martin DP, Exarhopoulos A, Moses MA, Schoen FJ, Sacks MS, Mayer JE. Endothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves. Tissue Eng Part A. 2010 Jan; 16(1):257-67. PMID: 19698056.
    Citations: 19     Fields:    Translation:AnimalsCells
  122. Ramaswamy S, Gottlieb D, Engelmayr GC, Aikawa E, Schmidt DE, Gaitan-Leon DM, Sales VL, Mayer JE, Sacks MS. The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells. Biomaterials. 2010 Feb; 31(6):1114-25. PMID: 19944458.
    Citations: 19     Fields:    Translation:AnimalsCells
  123. Panizzi P, Nahrendorf M, Wildgruber M, Waterman P, Figueiredo JL, Aikawa E, McCarthy J, Weissleder R, Hilderbrand SA. Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation. J Am Chem Soc. 2009 Nov 04; 131(43):15739-44. PMID: 19817443.
    Citations: 19     Fields:    Translation:Animals
  124. Nahrendorf M, Keliher E, Panizzi P, Zhang H, Hembrador S, Figueiredo JL, Aikawa E, Kelly K, Libby P, Weissleder R. 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis. JACC Cardiovasc Imaging. 2009 Oct; 2(10):1213-22. PMID: 19833312.
    Citations: 58     Fields:    Translation:AnimalsCells
  125. Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging. 2009 Nov; 2(6):460-7. PMID: 19920044.
    Citations: 36     Fields:    Translation:AnimalsCells
  126. Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging. 2009 Nov; 2(6):468-75. PMID: 19920045.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  127. Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009 Jul 31; 325(5940):612-6. PMID: 19644120.
    Citations: 591     Fields:    Translation:AnimalsCells
  128. Deguchi JO, Yamazaki H, Aikawa E, Aikawa M. Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages. Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1664-70. PMID: 19644051.
    Citations: 12     Fields:    Translation:HumansCells
  129. Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R. Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors. Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1444-51. PMID: 19608968.
    Citations: 73     Fields:    Translation:Animals
  130. Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Handschumacher MD, Sullivan S, Johnson B, Titus JS, Iwamoto Y, Wylie-Sears J, Levine RA, Carpentier A. Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation. Circulation. 2009 Jul 28; 120(4):334-42. PMID: 19597052.
    Citations: 52     Fields:    Translation:Animals
  131. Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L. The antiproliferative cytostatic effects of a self-activating viridin prodrug. Mol Cancer Ther. 2009 Jun; 8(6):1666-75. PMID: 19509266.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  132. Christen T, Nahrendorf M, Wildgruber M, Swirski FK, Aikawa E, Waterman P, Shimizu K, Weissleder R, Libby P. Molecular imaging of innate immune cell function in transplant rejection. Circulation. 2009 Apr 14; 119(14):1925-32. PMID: 19332470.
    Citations: 30     Fields:    Translation:AnimalsCells
  133. Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation. 2009 Apr 07; 119(13):1785-94. PMID: 19307473.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  134. Sosnovik DE, Wang R, Dai G, Wang T, Aikawa E, Novikov M, Rosenzweig A, Gilbert RJ, Wedeen VJ. Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging. 2009 May; 2(3):206-12. PMID: 19808594.
    Citations: 42     Fields:    Translation:AnimalsCells
  135. Kelly KA, Shaw SY, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R. Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries. Integr Biol (Camb). 2009 Apr; 1(4):311-7. PMID: 20023731.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  136. Deguchi JO, Huang H, Libby P, Aikawa E, Whittaker P, Sylvan J, Lee RT, Aikawa M. Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II. Lab Invest. 2009 Mar; 89(3):315-26. PMID: 19153555.
    Citations: 19     Fields:    Translation:Animals
  137. McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW. Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage. 2009 Apr 01; 45(2):360-9. PMID: 19154791.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  138. Niedre MJ, de Kleine RH, Aikawa E, Kirsch DG, Weissleder R, Ntziachristos V. Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19126-31. PMID: 19015534.
    Citations: 42     Fields:    Translation:Animals
  139. Breckwoldt MO, Chen JW, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz MA, Weissleder R. Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18584-9. PMID: 19011099.
    Citations: 84     Fields:    Translation:Animals
  140. Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R. Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation. 2008 Oct 28; 118(18):1802-9. PMID: 18852366.
    Citations: 83     Fields:    Translation:AnimalsCells
  141. Garanger E, Aikawa E, Reynolds F, Weissleder R, Josephson L. Simplified syntheses of complex multifunctional nanomaterials. Chem Commun (Camb). 2008 Oct 21; (39):4792-4. PMID: 18830495.
    Citations: 12     Fields:    Translation:Cells
  142. Rusanescu G, Weissleder R, Aikawa E. Notch signaling in cardiovascular disease and calcification. Curr Cardiol Rev. 2008 Aug; 4(3):148-56. PMID: 19936191.
    Citations: 23     Fields:    
  143. Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation. 2008 Mar 04; 117(9):1153-60. PMID: 18268141.
    Citations: 59     Fields:    Translation:Animals
  144. Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne SW, Blankesteijn WM, Sosnovik DE, Jaffer FA, Tung CH, Weissleder R. Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction. Eur Heart J. 2008 Feb; 29(4):445-54. PMID: 18276618.
    Citations: 22     Fields:    Translation:HumansAnimals
  145. Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R. Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. Brain. 2008 Apr; 131(Pt 4):1123-33. PMID: 18234693.
    Citations: 39     Fields:    Translation:AnimalsCells
  146. Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder R. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008 Jan 22; 117(3):379-87. PMID: 18158358.
    Citations: 167     Fields:    Translation:AnimalsCells
  147. Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH, Jaffer FA, Aikawa M, Weissleder R. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation. 2007 Dec 11; 116(24):2841-50. PMID: 18040026.
    Citations: 152     Fields:    Translation:HumansAnimals
  148. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007 Nov 26; 204(12):3037-47. PMID: 18025128.
    Citations: 603     Fields:    Translation:AnimalsCells
  149. Mendelson K, Aikawa E, Mettler BA, Sales V, Martin D, Mayer JE, Schoen FJ. Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep. Cardiovasc Pathol. 2007 Sep-Oct; 16(5):277-82. PMID: 17868878.
    Citations: 3     Fields:    Translation:AnimalsCells
  150. Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R. Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor. Circulation. 2007 May 01; 115(17):2292-8. PMID: 17420353.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  151. Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande AN, Aikawa E, Figueiredo JL, Pittet MJ, Weissleder R. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res. 2007 Apr 27; 100(8):1218-25. PMID: 17379832.
    Citations: 72     Fields:    Translation:AnimalsCells
  152. Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation. 2007 Mar 20; 115(11):1384-91. PMID: 17339546.
    Citations: 75     Fields:    Translation:AnimalsCells
  153. Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 2007 Jan 23; 115(3):377-86. PMID: 17224478.
    Citations: 122     Fields:    Translation:AnimalsCells
  154. Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007 Jan; 117(1):195-205. PMID: 17200719.
    Citations: 407     Fields:    Translation:AnimalsCells
  155. Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation. 2006 Oct 03; 114(14):1504-11. PMID: 17000904.
    Citations: 167     Fields:    Translation:AnimalsCells
  156. Paruchuri S, Yang JH, Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J. Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2. Circ Res. 2006 Oct 13; 99(8):861-9. PMID: 16973908.
    Citations: 61     Fields:    Translation:HumansCells
  157. Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation. 2006 Jul 04; 114(1):55-62. PMID: 16801460.
    Citations: 113     Fields:    Translation:AnimalsCells
  158. Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R. Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10340-10345. PMID: 16801531.
    Citations: 116     Fields:    Translation:AnimalsCells
  159. Heller EA, Liu E, Tager AM, Yuan Q, Lin AY, Ahluwalia N, Jones K, Koehn SL, Lok VM, Aikawa E, Moore KJ, Luster AD, Gerszten RE. Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation. 2006 May 16; 113(19):2301-12. PMID: 16682613.
    Citations: 69     Fields:    Translation:AnimalsCells
  160. Jaffer FA, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R. Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials. Mol Imaging. 2006 Apr-Jun; 5(2):85-92. PMID: 16954022.
    Citations: 49     Fields:    Translation:AnimalsCells
  161. Aikawa E, Whittaker P, Farber M, Mendelson K, Padera RF, Aikawa M, Schoen FJ. Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering. Circulation. 2006 Mar 14; 113(10):1344-52. PMID: 16534030.
    Citations: 114     Fields:    Translation:HumansCells
  162. Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA. Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy. J Biomed Opt. 2006 Mar-Apr; 11(2):021009. PMID: 16674184.
    Citations: 20     Fields:    Translation:Animals
  163. Aikawa E, Figueiredo JL, Kohler R, Shtatland T, Jaffer FA, Weissleder R. . Dynamic in vivo detection of vascular calcification in atherosclerosis. Abstract, SMI. 2006.
  164. Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer JA, Aikawa M, Weissleder R. . Molecular imaging identifies inflammation and precalcification in aortic valve disease. . Abstract, AHA. 2006.
  165. Deguchi JO, Aikawa E, Libby P, Vachon JR, Inada M, Krane SM, Whittaker P, Aikawa M. Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation. 2005 Oct 25; 112(17):2708-15. PMID: 16230484.
    Citations: 67     Fields:    Translation:Animals
  166. Larose E, Yeghiazarians Y, Libby P, Yucel EK, Aikawa M, Kacher DF, Aikawa E, Kinlay S, Schoen FJ, Selwyn AP, Ganz P. Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging. Circulation. 2005 Oct 11; 112(15):2324-31. PMID: 16203910.
    Citations: 32     Fields:    Translation:Humans
  167. Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE. Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation. 2005 Jul 26; 112(4):578-86. PMID: 16043658.
    Citations: 37     Fields:    Translation:AnimalsCells
  168. Sutherland FW, Perry TE, Yu Y, Sherwood MC, Rabkin E, Masuda Y, Garcia GA, McLellan DL, Engelmayr GC, Sacks MS, Schoen FJ, Mayer JE. From stem cells to viable autologous semilunar heart valve. Circulation. 2005 May 31; 111(21):2783-91. PMID: 15927990.
    Citations: 43     Fields:    Translation:AnimalsCells
  169. Rabkin-Aikawa E, Mayer JE, Schoen FJ. Heart valve regeneration. Adv Biochem Eng Biotechnol. 2005; 94:141-79. PMID: 15915872.
    Citations: 25     Fields:    Translation:Humans
  170. Rabkin-Aikawa E, Mayer JE, Jr, Schoen FJ. Heart valve regeneration. Advances in Biochemical Engineering/Biotechnology. Regenerative Medicine II. Ed. Yannas IV. 2005; 141-179.
  171. Engelmayr GC, Rabkin E, Sutherland FW, Schoen FJ, Mayer JE, Sacks MS. The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue. Biomaterials. 2005 Jan; 26(2):175-87. PMID: 15207464.
    Citations: 24     Fields:    Translation:AnimalsCells
  172. Rabkin-Aikawa E, Aikawa M, Farber M, Kratz JR, Garcia-Cardena G, Kouchoukos NT, Mitchell MB, Jonas RA, Schoen FJ. Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site. J Thorac Cardiovasc Surg. 2004 Oct; 128(4):552-61. PMID: 15457156.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  173. Fukumoto Y, Deguchi JO, Libby P, Rabkin-Aikawa E, Sakata Y, Chin MT, Hill CC, Lawler PR, Varo N, Schoen FJ, Krane SM, Aikawa M. Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques. Circulation. 2004 Oct 05; 110(14):1953-9. PMID: 15451791.
    Citations: 23     Fields:    Translation:AnimalsCells
  174. Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ. Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. J Heart Valve Dis. 2004 Sep; 13(5):841-7. PMID: 15473488.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  175. Wu X, Rabkin-Aikawa E, Guleserian KJ, Perry TE, Masuda Y, Sutherland FW, Schoen FJ, Mayer JE, Bischoff J. Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2):H480-7. PMID: 15277191.
    Citations: 42     Fields:    Translation:HumansCells
  176. Simoncini T, Rabkin E, Liao JK. Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells. Arterioscler Thromb Vasc Biol. 2003 Feb 01; 23(2):198-203. PMID: 12588759.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  177. Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, Bischoff J. NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells. J Biol Chem. 2003 Jan 17; 278(3):1686-92. PMID: 12427739.
    Citations: 36     Fields:    Translation:HumansCells
  178. Rabkin E, Schoen FJ. Cardiovascular tissue engineering. Cardiovasc Pathol. 2002 Nov-Dec; 11(6):305-17. PMID: 12459430.
    Citations: 12     Fields:    Translation:Humans
  179. Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 2002 Sep 10; 106(11):1390-6. PMID: 12221058.
    Citations: 34     Fields:    Translation:Animals
  180. Rabkin E, Hoerstrup SP, Aikawa M, Mayer JE, Schoen FJ. Evolution of cell phenotype and extracellular matrix in tissue-engineered heart valves during in-vitro maturation and in-vivo remodeling. J Heart Valve Dis. 2002 May; 11(3):308-14; discussion 314. PMID: 12056720.
    Citations: 26     Fields:    Translation:AnimalsCells
  181. Lindsey ML, Gannon J, Aikawa M, Schoen FJ, Rabkin E, Lopresti-Morrow L, Crawford J, Black S, Libby P, Mitchell PG, Lee RT. Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation. 2002 Feb 12; 105(6):753-8. PMID: 11839633.
    Citations: 50     Fields:    Translation:Animals
  182. Rabkin E. Common pathway for environment-mediated remodeling of heart valves. ISACB Circulator. 2002; 12-15.
  183. Rabkin E, Aikawa M, Stone JR, Fukumoto Y, Libby P, Schoen FJ. Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation. 2001 Nov 20; 104(21):2525-32. PMID: 11714645.
    Citations: 155     Fields:    Translation:HumansCells
  184. Paranya G, Vineberg S, Dvorin E, Kaushal S, Roth SJ, Rabkin E, Schoen FJ, Bischoff J. Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro. Am J Pathol. 2001 Oct; 159(4):1335-43. PMID: 11583961.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  185. Kaushal S, Amiel GE, Guleserian KJ, Shapira OM, Perry T, Sutherland FW, Rabkin E, Moran AM, Schoen FJ, Atala A, Soker S, Bischoff J, Mayer JE. Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo. Nat Med. 2001 Sep; 7(9):1035-40. PMID: 11533707.
    Citations: 145     Fields:    Translation:AnimalsCells
  186. Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy. Nat Med. 2001 Jun; 7(6):738-41. PMID: 11385513.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  187. Fukumoto Y, Libby P, Rabkin E, Hill CC, Enomoto M, Hirouchi Y, Shiomi M, Aikawa M. Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits. Circulation. 2001 Feb 20; 103(7):993-9. PMID: 11181475.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  188. Aikawa M, Rabkin E, Sugiyama S, Voglic SJ, Fukumoto Y, Furukawa Y, Shiomi M, Schoen FJ, Libby P. An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation. 2001 Jan 16; 103(2):276-83. PMID: 11208689.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  189. Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly RA, Werb Z, Libby P, Lee RT. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest. 2000 Jul; 106(1):55-62. PMID: 10880048.
    Citations: 217     Fields:    Translation:Animals
  190. Laufs U, Endres M, Stagliano N, Amin-Hanjani S, Chui DS, Yang SX, Simoncini T, Yamada M, Rabkin E, Allen PG, Huang PL, Böhm M, Schoen FJ, Moskowitz MA, Liao JK. Neuroprotection mediated by changes in the endothelial actin cytoskeleton. J Clin Invest. 2000 Jul; 106(1):15-24. PMID: 10880044.
    Citations: 63     Fields:    Translation:AnimalsCells
  191. Aikawa M, Fukumoto Y, Rabkin E, Libby P. . Rabbit models of atherosclerosis. Simon DI and Rogers C, Vascular Disease and Injury: Pre-clinical Research. 2000; 175-191.
  192. Aikawa M, Voglic SJ, Sugiyama S, Rabkin E, Taubman MB, Fallon JT, Libby P. Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. Circulation. 1999 Sep 14; 100(11):1215-22. PMID: 10484543.
    Citations: 22     Fields:    Translation:Animals
  193. Sukhova GK, Schönbeck U, Rabkin E, Schoen FJ, Poole AR, Billinghurst RC, Libby P. Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation. 1999 May 18; 99(19):2503-9. PMID: 10330380.
    Citations: 114     Fields:    Translation:Humans
  194. Aikawa M, Rabkin E, Voglic SJ, Shing H, Nagai R, Schoen FJ, Libby P. Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma. Circ Res. 1998 Nov 16; 83(10):1015-26. PMID: 9815149.
    Citations: 21     Fields:    Translation:AnimalsCells
  195. Aikawa M, Rabkin E, Okada Y, Voglic SJ, Clinton SK, Brinckerhoff CE, Sukhova GK, Libby P. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Circulation. 1998 Jun 23; 97(24):2433-44. PMID: 9641696.
    Citations: 86     Fields:    Translation:AnimalsCells
  196. Nakagawa T, Sukhova GK, Rabkin E, Winters GL, Schoen FJ, Libby P. Acute rejection accelerates graft coronary disease in transplanted rabbit hearts. Circulation. 1995 Aug 15; 92(4):987-93. PMID: 7641383.
    Citations: 7     Fields:    Translation:Animals
  197. Vlasov PA, Shashlov SV, Rabkin E, Shevchenko AA. . Reaction of kidney juxtaglomerular apparatus and APUD-system cells to irradiation. . Proceedings Proceedings of International Society for Pathophysiology . 1991; 171.
  198. Shashlov SV, Rabkin E. . Morphofunctional characteristics of the liver in the cerebral form of acute radiation sickness. Radiobiologiia. 1990; 30:477-481.
  199. Kawano J, Kotani T, Ohtaki S, Minamino N, Matsuo H, Oinuma T, Aikawa E. Characterization of rat and human steroid sulfatases. Biochim Biophys Acta. 1989 Aug 31; 997(3):199-205. PMID: 2765556.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  200. Rabkin E. Morphofunctional Characteristic of the pancreatic cells in the cerebral form of acute radiation sickness. 1989.