Harvard Catalyst Profiles

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Elena Aikawa, Ph.D., M.D.

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Novel Mechanism of Atherosclerotic Plaque Rupture: Zooming in on the Genesis of Microcalcifications
Summer, 06/26/14 - 08/29/14

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL147095 (AIKAWA, ELENA) Apr 1, 2019 - Mar 31, 2023
    New driver of fibrosis and calcification in CAVD
    Role: Principal Investigator
  2. R01HL141917 (LEVINE, ROBERT A) Apr 1, 2018 - Mar 31, 2022
    Improving Mitral Compensation In Ischemic Regurgitation
    Role: Co-Principal Investigator
  3. R01HL136431 (AIKAWA, ELENA) Mar 24, 2017 - Feb 28, 2021
    Macrophage-derived microcalcificaitons
    Role: Principal Investigator
  4. R01HL114805 (AIKAWA, ELENA) Aug 23, 2012 - Jun 30, 2018
    Aortic valve microcalcification
    Role: Principal Investigator
  5. R01HL109506 (LEVINE, ROBERT A) May 15, 2012 - Apr 30, 2017
    Improving Mitral Compensation in Ischemic Regurgitation
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Alvandi Z, Nagata Y, Passos LSA, Hashemi Gheinani A, Guerrero JL, Wylie-Sears J, Romero DC, Morris BA, Sullivan SM, Yaghoubian KM, Alvandi A, Adam RM, Aikawa E, Levine RA, Bischoff J. Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition. J Am Heart Assoc. 2022 Apr 05; 11(7):e023695. PMID: 35348006.
    Citations:    Fields:    
  2. Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsur M, Lacroix R, Lim SK, Mackman N, Mayr M, Menasché P, Nieuwland R, Sahoo S, Takov K, Thum T, Vader P, Wauben MHM, Witwer K, Sluijter JPG. Methods for the identification and characterization of extracellular vesicles in cardiovascular studies - from exosomes to microvesicles. Cardiovasc Res. 2022 Mar 24. PMID: 35325061.
    Citations:    Fields:    
  3. Gomes NFA, Silva VR, Levine RA, Esteves WAM, de Castro ML, Passos LSA, Dal-Bianco JP, Pantaleão AN, da Silva JLP, Tan TC, Dutra WO, Aikawa E, Hung J, Nunes MCP. Progression of Mitral Regurgitation in Rheumatic Valve Disease: Role of Left Atrial Remodeling. Front Cardiovasc Med. 2022; 9:862382. PMID: 35360029.
  4. Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E. Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease. Circulation. 2022 02 15; 145(7):531-548. PMID: 35157519.
    Citations:    Fields:    Translation:HumansCells
  5. Kraler S, Blaser MC, Aikawa E, Camici GG, Lüscher TF. Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy. Eur Heart J. 2022 02 12; 43(7):683-697. PMID: 34849696.
    Citations: 2     Fields:    
  6. Buffolo F, Monticone S, Camussi G, Aikawa E. Role of Extracellular Vesicles in the Pathogenesis of Vascular Damage. Hypertension. 2022 Feb 11; HYPERTENSIONAHA12117957. PMID: 35144490.
    Citations:    Fields:    
  7. Rogers MA, Atkins SK, Zheng KH, Singh SA, Chelvanambi S, Pham TH, Kuraoka S, Stroes ESG, Aikawa M, Aikawa E. Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis. Front Cardiovasc Med. 2022; 9:778919. PMID: 35155626.
  8. Tanaka T, Asano T, Okui T, Kuraoka S, Singh SA, Aikawa M, Aikawa E. Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification. Front Cardiovasc Med. 2021; 8:826529. PMID: 35127876.
  9. Passos LSA, Becker-Greene D, Braulio R, Le TD, Gelape CL, de Almeida LFR, Rocha DPA, Gomes CAP, Esteves WAM, Passaglia LG, Dal-Bianco JP, Levine RA, Aikawa M, Hung J, Dutra WO, Nunes MCP, Aikawa E. Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty. Front Cardiovasc Med. 2021; 8:804111. PMID: 35127864.
  10. Human P, Bezuidenhout D, Aikawa E, Zilla P. Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost. Front Cardiovasc Med. 2021; 8:760635. PMID: 35059444.
  11. van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer RS. Controlled delivery of gold nanoparticle-coupled miRNA therapeutics via an injectable self-healing hydrogel. Nanoscale. 2021 Dec 16; 13(48):20451-20461. PMID: 34817483.
    Citations:    Fields:    Translation:HumansAnimalsCells
  12. Bartoli-Leonard F, Zimmer J, Aikawa E. Innate and adaptive immunity: the understudied driving force of heart valve disease. Cardiovasc Res. 2021 11 22; 117(13):2506-2524. PMID: 34432007.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  13. Iwata H, Osborn EA, Ughi GJ, Murakami K, Goettsch C, Hutcheson JD, Mauskapf A, Mattson PC, Libby P, Singh SA, Matamalas J, Aikawa E, Tearney GJ, Aikawa M, Jaffer FA. Highly Selective PPARa (Peroxisome Proliferator-Activated Receptor a) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging. J Am Heart Assoc. 2021 10 19; 10(20):e020834. PMID: 34632804.
    Citations:    Fields:    Translation:Animals
  14. Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E. Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion. Cardiovasc Res. 2021 09 28; 117(11):2340-2353. PMID: 33523181.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Zhang H, Chen ZB, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen PKP, Ouimet M, Sutton NR, Aikawa E. What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award. Arterioscler Thromb Vasc Biol. 2021 11; 41(11):2641-2647. PMID: 34547925.
    Citations:    Fields:    Translation:Humans
  16. Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC. Radiation Induces Valvular Interstitial Cell Calcific Response in an in vitro Model of Calcific Aortic Valve Disease. Front Cardiovasc Med. 2021; 8:687885. PMID: 34527708.
  17. Lupieri A, Nagata Y, Passos LSA, Beker-Greene D, Kirkwood KA, Wylie-Sears J, Alvandi Z, Higashi H, Hung JW, Singh SA, Bischoff J, Levine RA, Aikawa E. Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients. Front Cardiovasc Med. 2021; 8:688396. PMID: 34458332.
  18. Rogers MA, Aikawa E. Unbiased omics identifies mechanistic regulators of calcific aortic valve disease. Eur Heart J. 2021 08 07; 42(30):2948-2950. PMID: 34179985.
    Citations:    Fields:    Translation:Humans
  19. Bartoli-Leonard F, Aikawa E. Recapitulating the Complex Pathology of Atherosclerosis: Which Model to Use? Circ Res. 2021 08 06; 129(4):491-493. PMID: 34351800.
    Citations: 1     Fields:    Translation:HumansCells
  20. Hutcheson JD, Schlotter F, Creager MD, Li X, Pham T, Vyas P, Higashi H, Body SC, Aikawa M, Singh SA, Kos L, Aikawa E. Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets. Front Cardiovasc Med. 2021; 8:678401. PMID: 34239903.
    Citations: 1     
  21. Bartoli-Leonard F, Aikawa E. Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease. Circ Res. 2021 04 30; 128(9):1317-1319. PMID: 33914606.
    Citations: 2     Fields:    Translation:Humans
  22. Blaser MC, Kraler S, Lüscher TF, Aikawa E. Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis. Circ Res. 2021 04 30; 128(9):1371-1397. PMID: 33914608.
    Citations: 6     Fields:    Translation:HumansCells
  23. Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E. Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model. Proc Natl Acad Sci U S A. 2021 04 06; 118(14). PMID: 33795519.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  24. Decano JL, Singh SA, Gasparotto Bueno C, Ho Lee L, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M. Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARa Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development. Circulation. 2021 06 22; 143(25):2454-2470. PMID: 33821665.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  25. de Freitas RCC, Hirata RDC, Hirata MH, Aikawa E. Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases. Biomolecules. 2021 03 05; 11(3). PMID: 33808038.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  26. Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF. ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves. Int J Cardiol. 2021 06 01; 332:159-161. PMID: 33626387.
    Citations:    Fields:    Translation:Animals
  27. Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7(6). PMID: 33547080.
    Citations: 7     Fields:    
  28. Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO, Nunes MCP. Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis. Front Cardiovasc Med. 2020; 7:604826. PMID: 33614739.
  29. Passos LSA, Nunes MCP, Aikawa E. Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms. Front Cardiovasc Med. 2020; 7:612716. PMID: 33537348.
    Citations: 5     
  30. Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E. ApoC-III is a novel inducer of calcification in human aortic valves. J Biol Chem. 2021 Jan-Jun; 296:100193. PMID: 33334888.
    Citations: 8     Fields:    Translation:HumansCells
  31. Atkins SK, Singh SA, Aikawa E. Calcific Aortic Valve Disease "Omics" Is Timely, But Are We Looking Too Late? JACC Basic Transl Sci. 2020 Dec; 5(12):1178-1180. PMID: 33427821.
    Citations: 2     
  32. Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E. CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction. Arterioscler Thromb Vasc Biol. 2021 02; 41(2):755-768. PMID: 33356393.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  33. Iqbal F, Lupieri A, Aikawa M, Aikawa E. Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2021 02; 41(2):585-600. PMID: 33327741.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  34. Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E. Raising awareness for rheumatic mitral valve disease. Glob Cardiol Sci Pract. 2020 Nov 30; 2020(2):e202026. PMID: 33426043.
    Citations: 1     
  35. Uiterwijk M, Smits AIPM, van Geemen D, van Klarenbosch B, Dekker S, Cramer MJ, van Rijswijk JW, Lurier EB, Di Luca A, Brugmans MCP, Mes T, Bosman AW, Aikawa E, Gründeman PF, Bouten CVC, Kluin J. In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves. JACC Basic Transl Sci. 2020 Dec; 5(12):1187-1206. PMID: 33426376.
    Citations: 4     
  36. Aikawa E, Blaser MC. 2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):117-127. PMID: 33115271.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  37. Bartoli-Leonard F, Aikawa E. Heart Valve Disease: Challenges and New Opportunities. Front Cardiovasc Med. 2020; 7:602271. PMID: 33195488.
    Citations: 2     
  38. Rogers MA, Aikawa E. An (Auto)Taxing Effort to Mechanistically Link Obesity and Calcific Aortic Valve Disease. JACC Basic Transl Sci. 2020 Sep; 5(9):898-900. PMID: 33016951.
    Citations: 1     
  39. Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E. Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Sci Adv. 2020 09; 6(38). PMID: 32938681.
    Citations: 21     Fields:    
  40. Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J. Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes. JACC Cardiovasc Imaging. 2020 12; 13(12):2513-2526. PMID: 32950446.
    Citations: 2     Fields:    Translation:Humans
  41. Christensen JL, Tan S, Chung HE, Ghosalkar DS, Qureshi R, Chu A, Yu W, Berus J, Shah NR, Wu WC, Chun H, Aikawa E, Choudhary G, Morrison AR. Aortic valve calcification predicts all-cause mortality independent of coronary calcification and severe stenosis. Atherosclerosis. 2020 08; 307:16-20. PMID: 32702536.
    Citations: 2     Fields:    Translation:Humans
  42. Bartoli-Leonard F, Saddic L, Aikawa E. Double-edged sword of ALDH2 mutations: one polymorphism can both benefit and harm the cardiovascular system. Eur Heart J. 2020 07 07; 41(26):2453-2455. PMID: 32585692.
    Citations: 1     Fields:    Translation:Humans
  43. Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E. S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2020 08; 40(8):1838-1853. PMID: 32460581.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  44. Passos LSA, Lupieri A, Becker-Greene D, Aikawa E. Innate and adaptive immunity in cardiovascular calcification. Atherosclerosis. 2020 08; 306:59-67. PMID: 32222287.
    Citations: 15     Fields:    Translation:HumansCells
  45. Rogers MA, Aikawa E. Complex association of lipoprotein(a) with aortic stenosis. Heart. 2020 05; 106(10):711-712. PMID: 32086294.
    Citations: 1     Fields:    Translation:Humans
  46. Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J. Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction. J Am Coll Cardiol. 2020 02 04; 75(4):395-405. PMID: 32000951.
    Citations: 2     Fields:    Translation:AnimalsCells
  47. Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J. Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):656-669. PMID: 31852220.
    Citations: 9     Fields:    Translation:HumansCells
  48. Rogers MA, Aikawa E. MicroRNA Extracellular Vesicle Stowaways in Cell-Cell Communication and Organ Crosstalk. Arterioscler Thromb Vasc Biol. 2019 12; 39(12):2448-2450. PMID: 31770027.
    Citations: 3     Fields:    Translation:Cells
  49. Atkins SK, Aikawa E. Valve under the microscope: shining a light on emerging technologies elucidating disease mechanisms. Heart. 2019 11; 105(21):1610-1611. PMID: 31296591.
    Citations: 1     Fields:    Translation:HumansCells
  50. Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR. Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis. J Am Coll Cardiol. 2019 05 07; 73(17):2150-2162. PMID: 31047003.
    Citations: 43     Fields:    Translation:Humans
  51. Rogers MA, Aikawa E. Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery. Nat Rev Cardiol. 2019 05; 16(5):261-274. PMID: 30531869.
    Citations: 38     Fields:    Translation:Humans
  52. Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E. Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification. Front Cardiovasc Med. 2019; 6:49. PMID: 31041314.
    Citations: 11     
  53. Phillippi JA, Aikawa E, Hutcheson J. Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine. Front Cardiovasc Med. 2019; 6:13. PMID: 30873414.
  54. Blaser MC, Aikawa E. Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis. Circ Res. 2019 02 15; 124(4):467-469. PMID: 30763209.
    Citations: 9     Fields:    Translation:HumansCells
  55. Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR. After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology. Front Cardiovasc Med. 2019; 6:8. PMID: 30838213.
  56. Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH. Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019 01 22; 73(2):190-209. PMID: 30654892.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  57. Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabási AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M. Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling. Circulation. 2019 01 02; 139(1):78-96. PMID: 30586693.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  58. Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E. 18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images. Circ Cardiovasc Imaging. 2019 01; 12(1):e007835. PMID: 30642216.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  59. Blaser MC, Aikawa E. Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism. Front Cardiovasc Med. 2018; 5:187. PMID: 30622949.
    Citations: 33     
  60. Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanovic MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Line A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL, Soares RP, Sódar BW, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018; 7(1):1535750. PMID: 30637094.
    Citations: 2313     Fields:    
  61. Koenen RR, Aikawa E. Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases. Front Cardiovasc Med. 2018; 5:133. PMID: 30283791.
    Citations: 4     
  62. Dekker S, van Geemen D, van den Bogaerdt AJ, Driessen-Mol A, Aikawa E, Smits AIPM. Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves. Front Cardiovasc Med. 2018; 5:105. PMID: 30159315.
    Citations: 5     
  63. Gottlieb Sen D, Halu A, Razzaque A, Gorham JM, Hartnett J, Seidman JG, Aikawa E, Seidman CE. The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development. Ann Thorac Surg. 2018 12; 106(6):1834-1840. PMID: 30071238.
    Citations: 4     Fields:    Translation:Humans
  64. Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E. Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease. Circulation. 2018 07 24; 138(4):377-393. PMID: 29588317.
    Citations: 62     Fields:    Translation:HumansCells
  65. Peeters FECM, Meex SJR, Dweck MR, Aikawa E, Crijns HJGM, Schurgers LJ, Kietselaer BLJH. Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment. Eur Heart J. 2018 07 21; 39(28):2618-2624. PMID: 29136138.
    Citations: 28     Fields:    Translation:Humans
  66. Hagita S, Rogers MA, Pham T, Wen JR, Mlynarchik AK, Aikawa M, Aikawa E. Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin. Sci Rep. 2018 06 13; 8(1):9006. PMID: 29899496.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  67. van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E. Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. Nanomaterials (Basel). 2018 May 03; 8(5). PMID: 29751516.
    Citations: 23     
  68. Hutcheson JD, Aikawa E. Extracellular vesicles in cardiovascular homeostasis and disease. Curr Opin Cardiol. 2018 05; 33(3):290-297. PMID: 29465447.
    Citations: 17     Fields:    Translation:HumansCells
  69. Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ. New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study. Eur Heart J. 2018 04 14; 39(15):1269-1277. PMID: 29020406.
    Citations: 14     Fields:    Translation:HumansCells
  70. Kim DH, Dal-Bianco JP, Aikawa E, Bischoff J, Levine RA. Mitral Valve Adaptation: Can We Win the Race? Circ Cardiovasc Imaging. 2018 04; 11(4):e007642. PMID: 29626080.
    Citations: 1     Fields:    Translation:Humans
  71. Hoganson DM, Cooper DA, Rich KN, Piekarski BL, Gui L, Gaut JP, Mayer JE, Aikawa E, Niklason LE, Emani SM. Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction. Ann Thorac Surg. 2018 06; 105(6):1809-1818. PMID: 29510094.
    Citations:    Fields:    Translation:Humans
  72. Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. Int J Mol Sci. 2018 Feb 27; 19(3). PMID: 29495441.
    Citations: 64     Fields:    Translation:HumansCells
  73. Itoh S, Mizuno K, Aikawa M, Aikawa E. Dimerization of sortilin regulates its trafficking to extracellular vesicles. J Biol Chem. 2018 03 23; 293(12):4532-4544. PMID: 29382723.
    Citations: 12     Fields:    Translation:HumansCells
  74. Sena BF, Figueiredo JL, Aikawa E. Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease. Front Cardiovasc Med. 2017; 4:88. PMID: 29379789.
    Citations: 9     
  75. Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK. Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation. JACC Cardiovasc Imaging. 2019 04; 12(4):665-677. PMID: 29248661.
    Citations: 15     Fields:    Translation:Humans
  76. Bakhshian Nik A, Hutcheson JD, Aikawa E. Extracellular Vesicles As Mediators of Cardiovascular Calcification. Front Cardiovasc Med. 2017; 4:78. PMID: 29322046.
    Citations: 33     
  77. Goettsch C, Kjolby M, Aikawa E. Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):19-25. PMID: 29191923.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  78. Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA. Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling. Circ Cardiovasc Imaging. 2017 Nov; 10(11). PMID: 29042413.
    Citations: 17     Fields:    Translation:HumansAnimals
  79. Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA. Effect of Losartan on Mitral Valve Changes After Myocardial Infarction. J Am Coll Cardiol. 2017 Sep 05; 70(10):1232-1244. PMID: 28859786.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  80. Rogers MA, Aikawa M, Aikawa E. Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues. Circ Res. 2017 06 23; 121(1):5-7. PMID: 28642321.
    Citations: 5     Fields:    Translation:HumansCells
  81. Rogers MA, Maldonado N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E. Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Circ Res. 2017 Jul 21; 121(3):220-233. PMID: 28607103.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  82. Masoumi N, Copper D, Chen P, Cubberley A, Guo K, Lin RZ, Ahmed B, Martin D, Aikawa E, Melero-Martin J, Mayer J. Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation. Adv Funct Mater. 2017 Jul 19; 27(27). PMID: 32863817.
    Citations: 1     
  83. Aikawa E, Libby P. A Rock and a Hard Place: Chiseling Away at the Multiple Mechanisms of Aortic Stenosis. Circulation. 2017 05 16; 135(20):1951-1955. PMID: 28507250.
    Citations: 18     Fields:    Translation:Humans
  84. Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P. Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion. Circ Res. 2017 Jun 23; 121(1):31-42. PMID: 28428204.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  85. Nagy E, Lei Y, Martínez-Martínez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E. Interferon-? Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves. Am J Pathol. 2017 Jun; 187(6):1413-1425. PMID: 28431214.
    Citations: 19     Fields:    Translation:HumansCells
  86. Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E. Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. Arterioscler Thromb Vasc Biol. 2017 05; 37(5):1005-1011. PMID: 28279970.
    Citations: 14     Fields:    Translation:HumansCells
  87. van der Ven CF, Wu PJ, Tibbitt MW, van Mil A, Sluijter JP, Langer R, Aikawa E. In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease. Clin Sci (Lond). 2017 02 01; 131(3):181-195. PMID: 28057890.
    Citations: 11     Fields:    Translation:HumansAnimals
  88. Hutcheson JD, Blaser MC, Aikawa E. Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field. Circ Res. 2017 01 20; 120(2):270-273. PMID: 28104767.
    Citations: 21     Fields:    Translation:HumansAnimals
  89. Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E. Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development. Front Cardiovasc Med. 2016; 3:44. PMID: 27867942.
    Citations: 5     
  90. Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Nat Commun. 2016 10 31; 7:12849. PMID: 27796300.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  91. Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko PE, Guerrero JL, Dal-Bianco JP, Beaudoin J, Garcia ML, Sullivan SM, Seybolt MM, Morris BA, Keegan J, Irvin WS, Aikawa E, Levine RA. CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction. Circ Res. 2016 Nov 11; 119(11):1215-1225. PMID: 27750208.
    Citations: 33     Fields:    Translation:AnimalsCells
  92. Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD. Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease. Cell Stem Cell. 2016 11 03; 19(5):628-642. PMID: 27618218.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  93. Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E. Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency. Semin Thorac Cardiovasc Surg. 2016 Winter; 28(4):757-767. PMID: 28417861.
    Citations: 4     Fields:    Translation:HumansCells
  94. Singh SA, Aikawa E, Aikawa M. Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research. Circ J. 2016 Jul 25; 80(8):1674-83. PMID: 27430298.
    Citations: 4     Fields:    Translation:HumansAnimals
  95. Dweck MR, Aikawa E, Newby DE, Tarkin JM, Rudd JH, Narula J, Fayad ZA. Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis. Circ Res. 2016 07 08; 119(2):330-40. PMID: 27390335.
    Citations: 58     Fields:    Translation:Humans
  96. Mosch J, Gleissner CA, Body S, Aikawa E. Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus. Histol Histopathol. 2017 Mar; 32(3):293-306. PMID: 27353274.
    Citations: 11     Fields:    Translation:Humans
  97. Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E. A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. Atherosclerosis. 2016 08; 251:109-118. PMID: 27318830.
    Citations: 38     Fields:    Translation:AnimalsCells