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Elena Aikawa, Ph.D., M.D.

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Mentoring
Novel Mechanism of Atherosclerotic Plaque Rupture: Zooming in on the Genesis of Microcalcifications
Summer, 06/26/14 - 08/29/14

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL147095 (AIKAWA, ELENA) Apr 1, 2019 - Mar 31, 2023
    NIH
    New driver of fibrosis and calcification in CAVD
    Role: Principal Investigator
  2. R01HL141917 (LEVINE, ROBERT A) Apr 1, 2018 - Mar 31, 2022
    NIH
    Improving Mitral Compensation In Ischemic Regurgitation
    Role: Co-Principal Investigator
  3. R01HL136431 (AIKAWA, ELENA) Mar 24, 2017 - Feb 28, 2021
    NIH
    Macrophage-derived microcalcificaitons
    Role: Principal Investigator
  4. R01HL114805 (AIKAWA, ELENA) Aug 23, 2012 - Jun 30, 2018
    NIH
    Aortic valve microcalcification
    Role: Principal Investigator
  5. R01HL109506 (LEVINE, ROBERT A) May 15, 2012 - Apr 30, 2017
    NIH
    Improving Mitral Compensation in Ischemic Regurgitation
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bartoli-Leonard F, Aikawa E. Old Drugs for an Old Pathology? Drug Repurposing for Calcific Aortic Valve Disease. Circ Res. 2021 Apr 30; 128(9):1317-1319. PMID: 33914606.
    Citations:    Fields:    
  2. Blaser MC, Kraler S, Lüscher TF, Aikawa E. Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis. Circ Res. 2021 Apr 30; 128(9):1371-1397. PMID: 33914608.
    Citations:    Fields:    
  3. Ruiz JL, Hutcheson JD, Cardoso L, Bakhshian Nik A, Condado de Abreu A, Pham T, Buffolo F, Busatto S, Federici S, Ridolfi A, Aikawa M, Bertazzo S, Bergese P, Weinbaum S, Aikawa E. Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model. Proc Natl Acad Sci U S A. 2021 Apr 06; 118(14). PMID: 33795519.
    Citations:    Fields:    
  4. Decano JL, Singh SA, Bueno CG, Lee LH, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M. Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPARa Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development. Circulation. 2021 Apr 06. PMID: 33821665.
    Citations:    Fields:    
  5. de Freitas RCC, Hirata RDC, Hirata MH, Aikawa E. Circulating Extracellular Vesicles As Biomarkers and Drug Delivery Vehicles in Cardiovascular Diseases. Biomolecules. 2021 Mar 05; 11(3). PMID: 33808038.
    Citations:    Fields:    
  6. Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF. ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves. Int J Cardiol. 2021 Jun 01; 332:159-161. PMID: 33626387.
    Citations:    Fields:    
  7. Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7(6). PMID: 33547080.
    Citations:    Fields:    
  8. Silva VR, Neves EGA, Passos LSA, Cristina de Melo F, Teixeira-Carvalho A, Nassif MCL, Junqueira LL, Aikawa E, Dutra WO, Nunes MCP. Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis. Front Cardiovasc Med. 2020; 7:604826. PMID: 33614739.
    Citations:    
  9. Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E. Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion. Cardiovasc Res. 2021 Feb 01. PMID: 33523181.
    Citations:    Fields:    
  10. Passos LSA, Nunes MCP, Aikawa E. Rheumatic Heart Valve Disease Pathophysiology and Underlying Mechanisms. Front Cardiovasc Med. 2020; 7:612716. PMID: 33537348.
    Citations:    
  11. Atkins SK, Singh SA, Aikawa E. Calcific Aortic Valve Disease "Omics" Is Timely, But Are We Looking Too Late? JACC Basic Transl Sci. 2020 Dec; 5(12):1178-1180. PMID: 33427821.
    Citations:    
  12. Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E. CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction. Arterioscler Thromb Vasc Biol. 2020 Dec 24; ATVBAHA120315007. PMID: 33356393.
    Citations:    Fields:    
  13. Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E. ApoC-III is a novel inducer of calcification in human aortic valves. J Biol Chem. 2020 Dec 17. PMID: 33334888.
    Citations:    Fields:    
  14. Iqbal F, Lupieri A, Aikawa M, Aikawa E. Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2020 Dec 17; ATVBAHA120314776. PMID: 33327741.
    Citations:    Fields:    
  15. Passos LSA, Nunes MCP, Zilla P, Yacoub MH, Aikawa E. Raising awareness for rheumatic mitral valve disease. Glob Cardiol Sci Pract. 2020 Nov 30; 2020(2):e202026. PMID: 33426043.
    Citations:    
  16. Uiterwijk M, Smits AIPM, van Geemen D, van Klarenbosch B, Dekker S, Cramer MJ, van Rijswijk JW, Lurier EB, Di Luca A, Brugmans MCP, Mes T, Bosman AW, Aikawa E, Gründeman PF, Bouten CVC, Kluin J. In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves. JACC Basic Transl Sci. 2020 Dec; 5(12):1187-1206. PMID: 33426376.
    Citations:    
  17. Aikawa E, Blaser MC. 2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):117-127. PMID: 33115271.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Bartoli-Leonard F, Aikawa E. Heart Valve Disease: Challenges and New Opportunities. Front Cardiovasc Med. 2020; 7:602271. PMID: 33195488.
    Citations:    
  19. Rogers MA, Aikawa E. An (Auto)Taxing Effort to Mechanistically Link Obesity and Calcific Aortic Valve Disease. JACC Basic Transl Sci. 2020 Sep; 5(9):898-900. PMID: 33016951.
    Citations:    
  20. Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E. Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Sci Adv. 2020 Sep; 6(38). PMID: 32938681.
    Citations: 6     Fields:    
  21. Nunes MCP, Levine RA, Braulio R, Pascoal-Xavier MA, Elmariah S, Gomes NFA, Soares JR, Esteves WAM, Zeng X, Dal-Bianco JP, Passos LSA, Passaglia LG, Ribeiro VT, Gelape CL, Costa PHN, Lodi-Junqueira L, Dutra W, Tan TC, Aikawa E, Hung J. Mitral Regurgitation After Percutaneous Mitral Valvuloplasty: Insights Into Mechanisms and Impact on Clinical Outcomes. JACC Cardiovasc Imaging. 2020 12; 13(12):2513-2526. PMID: 32950446.
    Citations:    Fields:    
  22. Christensen JL, Tan S, Chung HE, Ghosalkar DS, Qureshi R, Chu A, Yu W, Berus J, Shah NR, Wu WC, Chun H, Aikawa E, Choudhary G, Morrison AR. Aortic valve calcification predicts all-cause mortality independent of coronary calcification and severe stenosis. Atherosclerosis. 2020 08; 307:16-20. PMID: 32702536.
    Citations:    Fields:    
  23. Bartoli-Leonard F, Saddic L, Aikawa E. Double-edged sword of ALDH2 mutations: one polymorphism can both benefit and harm the cardiovascular system. Eur Heart J. 2020 07 07; 41(26):2453-2455. PMID: 32585692.
    Citations:    Fields:    Translation:Humans
  24. Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E. S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2020 08; 40(8):1838-1853. PMID: 32460581.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  25. Passos LSA, Lupieri A, Becker-Greene D, Aikawa E. Innate and adaptive immunity in cardiovascular calcification. Atherosclerosis. 2020 08; 306:59-67. PMID: 32222287.
    Citations: 6     Fields:    
  26. Rogers MA, Aikawa E. Complex association of lipoprotein(a) with aortic stenosis. Heart. 2020 05; 106(10):711-712. PMID: 32086294.
    Citations:    Fields:    Translation:Humans
  27. Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J. Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction. J Am Coll Cardiol. 2020 02 04; 75(4):395-405. PMID: 32000951.
    Citations: 2     Fields:    Translation:AnimalsCells
  28. Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J. Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):656-669. PMID: 31852220.
    Citations: 3     Fields:    Translation:HumansCells
  29. Rogers MA, Aikawa E. MicroRNA Extracellular Vesicle Stowaways in Cell-Cell Communication and Organ Crosstalk. Arterioscler Thromb Vasc Biol. 2019 12; 39(12):2448-2450. PMID: 31770027.
    Citations: 2     Fields:    Translation:Cells
  30. Atkins SK, Aikawa E. Valve under the microscope: shining a light on emerging technologies elucidating disease mechanisms. Heart. 2019 11; 105(21):1610-1611. PMID: 31296591.
    Citations:    Fields:    Translation:HumansCells
  31. Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR. Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis. J Am Coll Cardiol. 2019 05 07; 73(17):2150-2162. PMID: 31047003.
    Citations: 23     Fields:    Translation:Humans
  32. Rogers MA, Aikawa E. Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery. Nat Rev Cardiol. 2019 05; 16(5):261-274. PMID: 30531869.
    Citations: 21     Fields:    Translation:Humans
  33. Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E. Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification. Front Cardiovasc Med. 2019; 6:49. PMID: 31041314.
    Citations: 7     
  34. Phillippi JA, Aikawa E, Hutcheson J. Editorial: Exploring the Frontiers of Regenerative Cardiovascular Medicine. Front Cardiovasc Med. 2019; 6:13. PMID: 30873414.
    Citations:    
  35. Blaser MC, Aikawa E. Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis. Circ Res. 2019 02 15; 124(4):467-469. PMID: 30763209.
    Citations: 5     Fields:    Translation:HumansCells
  36. Hutcheson JD, Goergen CJ, Schoen FJ, Aikawa M, Zilla P, Aikawa E, Gaudette GR. After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology. Front Cardiovasc Med. 2019; 6:8. PMID: 30838213.
    Citations:    
  37. Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker AH. Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019 01 22; 73(2):190-209. PMID: 30654892.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  38. Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabási AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M. Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling. Circulation. 2019 01 02; 139(1):78-96. PMID: 30586693.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  39. Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E. 18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images. Circ Cardiovasc Imaging. 2019 01; 12(1):e007835. PMID: 30642216.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  40. Blaser MC, Aikawa E. Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism. Front Cardiovasc Med. 2018; 5:187. PMID: 30622949.
    Citations: 20     
  41. Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanovic MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Line A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL, Soares RP, Sódar BW, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018; 7(1):1535750. PMID: 30637094.
    Citations: 1227     
  42. Koenen RR, Aikawa E. Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases. Front Cardiovasc Med. 2018; 5:133. PMID: 30283791.
    Citations: 3     
  43. Dekker S, van Geemen D, van den Bogaerdt AJ, Driessen-Mol A, Aikawa E, Smits AIPM. Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves. Front Cardiovasc Med. 2018; 5:105. PMID: 30159315.
    Citations: 4     
  44. Gottlieb Sen D, Halu A, Razzaque A, Gorham JM, Hartnett J, Seidman JG, Aikawa E, Seidman CE. The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development. Ann Thorac Surg. 2018 12; 106(6):1834-1840. PMID: 30071238.
    Citations: 1     Fields:    Translation:Humans
  45. Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E. Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease. Circulation. 2018 07 24; 138(4):377-393. PMID: 29588317.
    Citations: 30     Fields:    Translation:HumansCells
  46. Peeters FECM, Meex SJR, Dweck MR, Aikawa E, Crijns HJGM, Schurgers LJ, Kietselaer BLJH. Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment. Eur Heart J. 2018 07 21; 39(28):2618-2624. PMID: 29136138.
    Citations: 16     Fields:    Translation:Humans
  47. Hagita S, Rogers MA, Pham T, Wen JR, Mlynarchik AK, Aikawa M, Aikawa E. Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin. Sci Rep. 2018 06 13; 8(1):9006. PMID: 29899496.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  48. van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E. Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. Nanomaterials (Basel). 2018 May 03; 8(5). PMID: 29751516.
    Citations: 16     
  49. Hutcheson JD, Aikawa E. Extracellular vesicles in cardiovascular homeostasis and disease. Curr Opin Cardiol. 2018 05; 33(3):290-297. PMID: 29465447.
    Citations: 10     Fields:    Translation:HumansCells
  50. Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ. New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study. Eur Heart J. 2018 04 14; 39(15):1269-1277. PMID: 29020406.
    Citations: 6     Fields:    Translation:HumansCells
  51. Kim DH, Dal-Bianco JP, Aikawa E, Bischoff J, Levine RA. Mitral Valve Adaptation: Can We Win the Race? Circ Cardiovasc Imaging. 2018 04; 11(4):e007642. PMID: 29626080.
    Citations: 1     Fields:    Translation:Humans
  52. Hoganson DM, Cooper DA, Rich KN, Piekarski BL, Gui L, Gaut JP, Mayer JE, Aikawa E, Niklason LE, Emani SM. Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction. Ann Thorac Surg. 2018 06; 105(6):1809-1818. PMID: 29510094.
    Citations:    Fields:    Translation:Humans
  53. Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. Int J Mol Sci. 2018 Feb 27; 19(3). PMID: 29495441.
    Citations: 36     Fields:    Translation:HumansCells
  54. Itoh S, Mizuno K, Aikawa M, Aikawa E. Dimerization of sortilin regulates its trafficking to extracellular vesicles. J Biol Chem. 2018 03 23; 293(12):4532-4544. PMID: 29382723.
    Citations: 8     Fields:    Translation:HumansCells
  55. Sena BF, Figueiredo JL, Aikawa E. Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease. Front Cardiovasc Med. 2017; 4:88. PMID: 29379789.
    Citations: 4     
  56. Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK. Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation. JACC Cardiovasc Imaging. 2019 04; 12(4):665-677. PMID: 29248661.
    Citations: 8     Fields:    Translation:Humans
  57. Bakhshian Nik A, Hutcheson JD, Aikawa E. Extracellular Vesicles As Mediators of Cardiovascular Calcification. Front Cardiovasc Med. 2017; 4:78. PMID: 29322046.
    Citations: 24     
  58. Goettsch C, Kjolby M, Aikawa E. Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):19-25. PMID: 29191923.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  59. Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA. Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling. Circ Cardiovasc Imaging. 2017 Nov; 10(11). PMID: 29042413.
    Citations: 12     Fields:    Translation:HumansAnimals
  60. Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA. Effect of Losartan on Mitral Valve Changes After Myocardial Infarction. J Am Coll Cardiol. 2017 Sep 05; 70(10):1232-1244. PMID: 28859786.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  61. Rogers MA, Aikawa M, Aikawa E. Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues. Circ Res. 2017 06 23; 121(1):5-7. PMID: 28642321.
    Citations: 5     Fields:    Translation:HumansCells
  62. Rogers MA, Maldonado N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E. Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Circ Res. 2017 Jul 21; 121(3):220-233. PMID: 28607103.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  63. Masoumi N, Copper D, Chen P, Cubberley A, Guo K, Lin RZ, Ahmed B, Martin D, Aikawa E, Melero-Martin J, Mayer J. Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation. Adv Funct Mater. 2017 Jul 19; 27(27). PMID: 32863817.
    Citations: 1     
  64. Aikawa E, Libby P. A Rock and a Hard Place: Chiseling Away at the Multiple Mechanisms of Aortic Stenosis. Circulation. 2017 05 16; 135(20):1951-1955. PMID: 28507250.
    Citations: 12     Fields:    Translation:Humans
  65. Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P. Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion. Circ Res. 2017 Jun 23; 121(1):31-42. PMID: 28428204.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  66. Nagy E, Lei Y, Martínez-Martínez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E. Interferon-? Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves. Am J Pathol. 2017 Jun; 187(6):1413-1425. PMID: 28431214.
    Citations: 12     Fields:    Translation:HumansCells
  67. Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E. Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. Arterioscler Thromb Vasc Biol. 2017 05; 37(5):1005-1011. PMID: 28279970.
    Citations: 10     Fields:    Translation:HumansCells
  68. van der Ven CF, Wu PJ, Tibbitt MW, van Mil A, Sluijter JP, Langer R, Aikawa E. In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease. Clin Sci (Lond). 2017 02 01; 131(3):181-195. PMID: 28057890.
    Citations: 5     Fields:    Translation:HumansAnimals
  69. Hutcheson JD, Blaser MC, Aikawa E. Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field. Circ Res. 2017 01 20; 120(2):270-273. PMID: 28104767.
    Citations: 16     Fields:    Translation:HumansAnimals
  70. Yabusaki K, Hutcheson JD, Vyas P, Bertazzo S, Body SC, Aikawa M, Aikawa E. Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development. Front Cardiovasc Med. 2016; 3:44. PMID: 27867942.
    Citations: 2     
  71. Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Nat Commun. 2016 10 31; 7:12849. PMID: 27796300.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  72. Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko PE, Guerrero JL, Dal-Bianco JP, Beaudoin J, Garcia ML, Sullivan SM, Seybolt MM, Morris BA, Keegan J, Irvin WS, Aikawa E, Levine RA. CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction. Circ Res. 2016 Nov 11; 119(11):1215-1225. PMID: 27750208.
    Citations: 23     Fields:    Translation:AnimalsCells
  73. Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD. Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease. Cell Stem Cell. 2016 11 03; 19(5):628-642. PMID: 27618218.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  74. Hjortnaes J, Keegan J, Bruneval P, Schwartz E, Schoen FJ, Carpentier A, Levine RA, Hagège A, Aikawa E. Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency. Semin Thorac Cardiovasc Surg. 2016 Winter; 28(4):757-767. PMID: 28417861.
    Citations: 3     Fields:    Translation:HumansCells
  75. Singh SA, Aikawa E, Aikawa M. Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research. Circ J. 2016 Jul 25; 80(8):1674-83. PMID: 27430298.
    Citations: 2     Fields:    Translation:HumansAnimals
  76. Dweck MR, Aikawa E, Newby DE, Tarkin JM, Rudd JH, Narula J, Fayad ZA. Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis. Circ Res. 2016 07 08; 119(2):330-40. PMID: 27390335.
    Citations: 45     Fields:    Translation:Humans
  77. Mosch J, Gleissner CA, Body S, Aikawa E. Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus. Histol Histopathol. 2017 Mar; 32(3):293-306. PMID: 27353274.
    Citations: 7     Fields:    Translation:Humans
  78. Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E. A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. Atherosclerosis. 2016 08; 251:109-118. PMID: 27318830.
    Citations: 22     Fields:    Translation:AnimalsCells
  79. Aikawa E. Extracellular vesicles in cardiovascular disease: focus on vascular calcification. J Physiol. 2016 06 01; 594(11):2877-80. PMID: 27246548.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  80. Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E. Extracellular vesicles in cardiovascular calcification: expanding current paradigms. J Physiol. 2016 06 01; 594(11):2895-903. PMID: 26824781.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  81. O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R. Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation. J Vis Exp. 2016 05 31; (111). PMID: 27284788.
    Citations: 4     Fields:    Translation:HumansAnimals
  82. Ruiz JL, Weinbaum S, Aikawa E, Hutcheson JD. Zooming in on the genesis of atherosclerotic plaque microcalcifications. J Physiol. 2016 06 01; 594(11):2915-27. PMID: 27040360.
    Citations: 10     Fields:    Translation:HumansAnimals
  83. Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Aikawa E. Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation. J Mol Cell Cardiol. 2016 05; 94:13-20. PMID: 26996755.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  84. Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA. 3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR. Eur Heart J Cardiovasc Imaging. 2016 May; 17(5):510-1. PMID: 26976355.
    Citations:    Fields:    Translation:Humans
  85. Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016 Apr 01; 126(4):1323-36. PMID: 26950419.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  86. Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA. Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve. J Am Coll Cardiol. 2016 Jan 26; 67(3):275-87. PMID: 26796392.
    Citations: 26     Fields:    Translation:Animals
  87. Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E. Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-ß Signaling. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):525-33. PMID: 26800565.
    Citations: 20     Fields:    Translation:AnimalsCells
  88. Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E. Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nat Mater. 2016 Mar; 15(3):335-43. PMID: 26752654.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  89. Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH. Mitral valve disease--morphology and mechanisms. Nat Rev Cardiol. 2015 Dec; 12(12):689-710. PMID: 26483167.
    Citations: 60     Fields:    Translation:Humans
  90. Shibasaki M, Wang JG, Figueiredo JL, New SE, Quillard T, Goettsch C, Koga J, Sonoki H, Matsumoto J, Aikawa M, Aikawa E. Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease. PLoS One. 2015; 10(9):e0138047. PMID: 26367531.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  91. Hutcheson JD, Goettsch C, Rogers MA, Aikawa E. Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach. Semin Cell Dev Biol. 2015 Oct; 46:68-77. PMID: 26358815.
    Citations: 8     Fields:    Translation:HumansAnimals
  92. Rogers MA, Aikawa E. A Not-So-Little Role for Lipoprotein(a) in the Development of Calcific Aortic Valve Disease. Circulation. 2015 Aug 25; 132(8):621-3. PMID: 26224809.
    Citations: 5     Fields:    Translation:HumansAnimals
  93. Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J, Aikawa E. Valvular interstitial cells suppress calcification of valvular endothelial cells. Atherosclerosis. 2015 Sep; 242(1):251-260. PMID: 26232165.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  94. Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E. N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification. J Cardiovasc Dev Dis. 2015 Apr 15; 2(2):31-47. PMID: 29371511.
    Citations: 1     
  95. Lei Y, Iwashita M, Choi J, Aikawa M, Aikawa E. N-acetylglucosamine-1-Pthosphate transferase Suppresses Lysosamal Hydrolases in Dysphunctional Osteoclasts: A Potential Mechanism for Vascular Calcification. Journal of Cardiovascular Development and Disease. 2015; (2):31-47.
  96. Ruiz JL, Hutcheson JD, Aikawa E. Cardiovascular calcification: current controversies and novel concepts. Cardiovasc Pathol. 2015 Jul-Aug; 24(4):207-12. PMID: 25797772.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  97. Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W, Hartmann G, Aikawa E. Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease. Am J Pathol. 2015 Apr; 185(4):1156-66. PMID: 25680278.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  98. Hutcheson JD, Aikawa E. Cardiovascular imaging: Arterial and aortic valve inflammation and calcification. Ed. Aikawa E. Pathobiology and optical molecular imaging of calcific aortic valve disease. 2014; pp. 187-201.
  99. Hutcheson JD, Aikawa E. Cardiovascular imaging: Arterial and aortic valve inflammation and calcification. Ed. Aikawa E. Optical molecular imaging of inflammation and calcification in atherosclerosis. 2014; pp.107-121.
  100. Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E. Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol. J Extracell Vesicles. 2014; 3:25129. PMID: 25491249.
    Citations: 19     
  101. Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stepien E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics. 2015 Mar 15; 31(6):933-9. PMID: 25388151.
    Citations: 122     Fields:    Translation:HumansCells
  102. Hutcheson JD, Maldonado N, Aikawa E. Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability. Curr Opin Lipidol. 2014 Oct; 25(5):327-32. PMID: 25188916.
    Citations: 37     Fields:    Translation:Humans
  103. Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2014 Nov; 34(11):2387-93. PMID: 25189570.
    Citations: 69     Fields:    Translation:HumansCells
  104. Goettsch C, Iwata H, Aikawa E. Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1333-5. PMID: 24951650.
    Citations: 9     Fields:    Translation:Humans
  105. Hjortnaes J, Camci-Unal G, Hutcheson JD, Jung SM, Schoen FJ, Kluin J, Aikawa E, Khademhosseini A. Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform. Adv Healthc Mater. 2015 Jan 07; 4(1):121-30. PMID: 24958085.
    Citations: 17     Fields:    Translation:AnimalsCells
  106. Rogers MA, Aikawa E. Modifying vascular calcification in diabetes mellitus: contribution of O-GlcNAcylation. Circ Res. 2014 Mar 28; 114(7):1074-6. PMID: 24677232.
    Citations: 3     Fields:    Translation:Animals
  107. Yabusaki K, Faits T, McMullen E, Figueiredo JL, Aikawa M, Aikawa E. A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program. PLoS One. 2014; 9(3):e89627. PMID: 24595280.
    Citations: 4     Fields:    
  108. Hutcheson JD, Aikawa E, Merryman WD. Potential drug targets for calcific aortic valve disease. Nat Rev Cardiol. 2014 Apr; 11(4):218-31. PMID: 24445487.
    Citations: 41     Fields:    Translation:Humans
  109. Martinez Martinez E, Aikawa E. Molecular biology of valvular heart disease. Ed. Rajamannan NM. Identification of early pathological events in calcific aortic valve decease by molecular imaging. 2014; 107-117.
  110. Aikawa E, Schoen FJ. Calcific and degenerative heart valve disease. Cellular and molecular pathobiology of cardiovascular disease. Ed. Willis MS, Homeister JW, Stone JR. Elsevier. 2014.
  111. Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S, Aikawa E. Cystathionine ?-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):626-34. PMID: 24357058.
    Citations: 9     Fields:    Translation:AnimalsCells
  112. Aikawa E, Gardiner C, Hutcheson JD, Ochiya T, Osteikoetxea X, Pegtel M, Piper M, Quesenberry P, Schiffelers RM, Szabó TG, Buzas EI. International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013). J Extracell Vesicles. 2013; 2:23070. PMID: 26082318.
    Citations:    
  113. Rogers M, Goettsch C, Aikawa E. Medial and intimal calcification in chronic kidney disease: stressing the contributions. J Am Heart Assoc. 2013 Sep 23; 2(5):e000481. PMID: 24060959.
    Citations: 5     Fields:    Translation:Animals
  114. New SE, Aikawa E. Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1753-8. PMID: 23766262.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  115. Kelly-Arnold A, Maldonado N, Laudier D, Aikawa E, Cardoso L, Weinbaum S. Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10741-6. PMID: 23733926.
    Citations: 87     Fields:    Translation:Humans
  116. Wang JG, Aikawa E, Aikawa M. Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis. J Am Coll Cardiol. 2013 Oct 15; 62(16):1442-5. PMID: 23707315.
    Citations: 3     Fields:    Translation:HumansCells
  117. Votteler M, Berrio DA, Horke A, Sabatier L, Reinhardt DP, Nsair A, Aikawa E, Schenke-Layland K. Elastogenesis at the onset of human cardiac valve development. Development. 2013 Jun; 140(11):2345-53. PMID: 23637335.
    Citations: 16     Fields:    Translation:Humans
  118. New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E. Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques. Circ Res. 2013 Jun 21; 113(1):72-7. PMID: 23616621.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  119. Goettsch C, Hutcheson JD, Aikawa E. MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms. Circ Res. 2013 Mar 29; 112(7):1073-84. PMID: 23538277.
    Citations: 29     Fields:    Translation:HumansAnimals
  120. Abe J, Manabe I, Aikawa M, Aikawa E. Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation. Int J Inflam. 2013; 2013:953463. PMID: 23555068.
    Citations: 2     
  121. Hjortnaes J, New SE, Aikawa E. Visualizing novel concepts of cardiovascular calcification. Trends Cardiovasc Med. 2013 Apr; 23(3):71-9. PMID: 23290463.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  122. Goettsch C, Aikawa E. Role of microRNAs in Cardiovascular Calcification. In: Calcific Aortic Valve Disease. Aikawa E (ed). InTech, pp 123-149. 2013.
  123. Aikawa E, Gardiner C, Hutcheson JD, Ochiya T, Osteikoetxea X, Pegtel M, Piper M, Quesenberry P, Schiffelers RM, Szabo TG, Buzas EI. JEV. International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April, 2013, Boston, MA (ISEV 2013). 2013; (2):1-19.
  124. Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 2012; 10(12):e1001450. PMID: 23271954.
    Citations: 396     Fields:    Translation:Cells
  125. Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M. Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion. Eur Heart J. 2013 Feb; 34(8):615-24. PMID: 22927557.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  126. Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):E1868-77. PMID: 22699504.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  127. Aikawa M, Manabe I, Chester A, Aikawa E. Cardiovascular inflammation. Int J Inflam. 2012; 2012:904608. PMID: 22518345.
    Citations: 1     
  128. Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3):613-22. PMID: 22223731.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  129. Aikawa E, Grande-Allen KJ. Biology of Mitral valve Disease. In: Cardiac Valvular Medicine. Rajamannan NM (ed). Springer-Verlag, London, pp.173-187. 2012.
  130. Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):19943-8. PMID: 22123981.
    Citations: 46     Fields:    Translation:AnimalsCells
  131. Aikawa E, Otto CM. Look more closely at the valve: imaging calcific aortic valve disease. Circulation. 2012 Jan 03; 125(1):9-11. PMID: 22090164.
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