Harvard Catalyst Profiles

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Morris Francis White Jr., Ph.D.


Construction of IRS-2F21 to Study Phospho-Serine / Threonine Signaling in IRS-2
Summer, 06/01/05 - 08/10/05

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG067913 (WHITE, MORRIS F.) May 15, 2020 - Jan 31, 2025
    Regulation of hippocampal function by central and peripheral IRS signaling
    Role: Principal Investigator
  2. R01DK098655 (WHITE, MORRIS F.) Apr 1, 2013 - Jul 24, 2017
    Metabolic Crosstalk During Hepatic Insulin Resistance
    Role: Principal Investigator
  3. K12DK094721 (WHITE, MORRIS F.) Sep 16, 2011 - Jun 30, 2021
    Role: Co-Principal Investigator
  4. R13DK062427 (WHITE, MORRIS F.) Jun 6, 2002 - May 31, 2003
    Gordon Conference: Second Messengers and Phosphorylation
    Role: Principal Investigator
  5. R01DK055326 (WHITE, MORRIS F.) Sep 1, 2000 - Aug 31, 2005
    IRS2 function in beta cell physiology
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Stöhr O, Tao R, Miao J, Copps KD, White MF. FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance. Cell Rep. 2021 Mar 23; 34(12):108893. PMID: 33761350.
    Citations:    Fields:    
  2. Takayanagi Y, Ishizuka K, Laursen TM, Yukitake H, Yang K, Cascella NG, Ueda S, Sumitomo A, Narita Z, Horiuchi Y, Niwa M, Taguchi A, White MF, Eaton WW, Mortensen PB, Sakurai T, Sawa A. From population to neuron: exploring common mediators for metabolic problems and mental illnesses. Mol Psychiatry. 2020 Nov 10. PMID: 33173197.
    Citations:    Fields:    
  3. Sutton AK, Gonzalez IE, Sadagurski M, Rajala M, Lu C, Allison MB, Adams JM, Myers MG, White MF, Olson DP. Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance. Sci Rep. 2020 03 26; 10(1):5546. PMID: 32218485.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED. Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 03 26; 5(6). PMID: 32213702.
    Citations: 2     Fields:    
  5. Zhang K, Guo X, Yan H, Wu Y, Pan Q, Shen JZ, Li X, Chen Y, Li L, Qi Y, Xu Z, Xie W, Zhang W, Threadgill D, He L, Villarreal D, Sun Y, White MF, Zheng H, Guo S. Phosphorylation of Forkhead Protein FoxO1 at S253 Regulates Glucose Homeostasis in Mice. Endocrinology. 2019 05 01; 160(5):1333-1347. PMID: 30951171.
    Citations: 3     Fields:    Translation:AnimalsCells
  6. Xi G, Shen X, Wai C, White MF, Clemmons DR. Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1-mediated p53/KLF4 complex stabilization. J Biol Chem. 2019 02 15; 294(7):2407-2421. PMID: 30578299.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Kalvisa A, Siersbæk MS, Præstholm SM, Christensen LJL, Nielsen R, Stohr O, Vettorazzi S, Tuckermann J, White M, Mandrup S, Grøntved L. Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver. PLoS Biol. 2018 12; 16(12):e2006249. PMID: 30532187.
    Citations: 10     Fields:    Translation:AnimalsCells
  8. Huang H, Lee SH, Sousa-Lima I, Kim SS, Hwang WM, Dagon Y, Yang WM, Cho S, Kang MC, Seo JA, Shibata M, Cho H, Belew GD, Bhin J, Desai BN, Ryu MJ, Shong M, Li P, Meng H, Chung BH, Hwang D, Kim MS, Park KS, Macedo MP, White M, Jones J, Kim YB. Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition. J Clin Invest. 2018 12 03; 128(12):5335-5350. PMID: 30226474.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  9. Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia. Nat Med. 2018 Oct; 24(10):1628. PMID: 30111893.
    Citations:    Fields:    
  10. Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Inactivating hepatic follistatin alleviates hyperglycemia. Nat Med. 2018 07; 24(7):1058-1069. PMID: 29867232.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  11. Xu H, Lee MS, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY. Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):4228-4233. PMID: 29610318.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  12. Cao J, Peng J, An H, He Q, Boronina T, Guo S, White MF, Cole PA, He L. Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity. Nat Commun. 2017 07 25; 8(1):131. PMID: 28743992.
    Citations: 16     Fields:    Translation:AnimalsCells
  13. Long YC, Cheng Z, Copps KD, White MF. Correction for Long et al., "Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways". Mol Cell Biol. 2017 08 01; 37(15). PMID: 28710120.
    Citations:    Fields:    
  14. Xi G, Wai C, White MF, Clemmons DR. Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation. J Biol Chem. 2017 02 03; 292(5):2009-2020. PMID: 28003360.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  15. Law NC, White MF, Hunzicker-Dunn ME. G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway. J Biol Chem. 2016 12 30; 291(53):27160-27169. PMID: 27856640.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  16. Lavin DP, White MF, Brazil DP. IRS proteins and diabetic complications. Diabetologia. 2016 11; 59(11):2280-2291. PMID: 27514532.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  17. Metz HE, Kargl J, Busch SE, Kim KH, Kurland BF, Abberbock SR, Randolph-Habecker J, Knoblaugh SE, Kolls JK, White MF, Houghton AM. Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8795-800. PMID: 27439864.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  18. Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF. Trimeprazine increases IRS2 in human islets and promotes pancreatic ß cell growth and function in mice. JCI Insight. 2016; 1(3). PMID: 27152363.
    Citations: 1     Fields:    
  19. Copps KD, Hançer NJ, Qiu W, White MF. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. J Biol Chem. 2016 Apr 15; 291(16):8602-17. PMID: 26846849.
    Citations: 9     Fields:    Translation:AnimalsCells
  20. White MF. Longevity: Mapping the path to a longer life. Nature. 2015 Aug 13; 524(7564):170-1. PMID: 26268188.
    Citations:    Fields:    Translation:AnimalsCells
  21. Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED. Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Mol Cell Biol. 2014 Sep 15; 34(18):3450-60. PMID: 25002528.
    Citations: 36     Fields:    Translation:AnimalsCells
  22. Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ. APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. Cell Rep. 2014 May 22; 7(4):1227-38. PMID: 24813896.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  23. Hançer NJ, Qiu W, Cherella C, Li Y, Copps KD, White MF. Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem. 2014 May 02; 289(18):12467-84. PMID: 24652289.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  24. Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U. IRS1Ser³°7 phosphorylation does not mediate mTORC1-induced insulin resistance. Biochem Biophys Res Commun. 2014 Jan 10; 443(2):689-93. PMID: 24333417.
    Citations: 6     Fields:    Translation:AnimalsCells
  25. Qi Y, Xu Z, Zhu Q, Thomas C, Kumar R, Feng H, Dostal DE, White MF, Baker KM, Guo S. Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38a MAPK during insulin resistance. Diabetes. 2013 Nov; 62(11):3887-900. PMID: 24159000.
    Citations: 46     Fields:    Translation:AnimalsCells
  26. Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED. Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest. 2013 Dec; 123(12):5319-33. PMID: 24177427.
    Citations: 42     Fields:    Translation:AnimalsCells
  27. Sadagurski M, Dong XC, Myers MG, White MF. Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Mol Metab. 2014 Feb; 3(1):55-63. PMID: 24567904.
    Citations: 12     Fields:    
  28. Tao R, Xiong X, Harris RA, White MF, Dong XC. Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes. PLoS One. 2013; 8(8):e71997. PMID: 23940800.
    Citations: 23     Fields:    Translation:Animals
  29. Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Sci Signal. 2013 Jul 30; 6(286):ra64. PMID: 23901139.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  30. Rhodes CJ, White MF, Leahy JL, Kahn SE. Direct autocrine action of insulin on ß-cells: does it make physiological sense? Diabetes. 2013 Jul; 62(7):2157-63. PMID: 23801714.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  31. Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol. 2013 Aug; 33(16):3227-41. PMID: 23775122.
    Citations: 20     Fields:    Translation:AnimalsCells
  32. Geetha T, Rege SD, Mathews SE, Meakin SO, White MF, Babu JR. Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells. J Biol Chem. 2013 Aug 16; 288(33):23807-13. PMID: 23749991.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  33. Hookham MB, O'Donovan HC, Church RH, Mercier-Zuber A, Luzi L, Curran SP, Carew RM, Droguett A, Mezzano S, Schubert M, White MF, Crean JK, Brazil DP. Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy. FEBS J. 2013 Jul; 280(14):3232-43. PMID: 23617393.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  34. Jain S, Ruiz de Azua I, Lu H, White MF, Guettier JM, Wess J. Chronic activation of a designer G(q)-coupled receptor improves ß cell function. J Clin Invest. 2013 Apr; 123(4):1750-62. PMID: 23478411.
    Citations: 54     Fields:    Translation:AnimalsCells
  35. Sadagurski M, White MF. Integrating metabolism and longevity through insulin and IGF1 signaling. Endocrinol Metab Clin North Am. 2013 Mar; 42(1):127-48. PMID: 23391244.
    Citations: 11     Fields:    Translation:AnimalsCells
  36. Behl M, Rao D, Aagaard K, Davidson TL, Levin ED, Slotkin TA, Srinivasan S, Wallinga D, White MF, Walker VR, Thayer KA, Holloway AC. Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environ Health Perspect. 2013 Feb; 121(2):170-80. PMID: 23232494.
    Citations: 45     Fields:    Translation:HumansAnimals
  37. Matveyenko AV, Liuwantara D, Gurlo T, Kirakossian D, Dalla Man C, Cobelli C, White MF, Copps KD, Volpi E, Fujita S, Butler PC. Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes. 2012 Sep; 61(9):2269-79. PMID: 22688333.
    Citations: 57     Fields:    Translation:AnimalsCells
  38. Wang Z, Cheng Z, Cristofaro V, Li J, Xiao X, Gomez P, Ge R, Gong E, Strle K, Sullivan MP, Adam RM, White MF, Olumi AF. Inhibition of TNF-a improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes. 2012 Aug; 61(8):2134-45. PMID: 22688336.
    Citations: 21     Fields:    Translation:AnimalsCells
  39. Sadagurski M, Leshan RL, Patterson C, Rozzo A, Kuznetsova A, Skorupski J, Jones JC, Depinho RA, Myers MG, White MF. IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab. 2012 May 02; 15(5):703-12. PMID: 22560222.
    Citations: 29     Fields:    Translation:AnimalsCells
  40. Cheng Z, White MF. kNOXing on the door of selective insulin resistance. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1063-5. PMID: 22517360.
    Citations: 1     Fields:    Translation:Animals
  41. Cheng Z, White MF. The AKTion in non-canonical insulin signaling. Nat Med. 2012 Mar 06; 18(3):351-3. PMID: 22395698.
    Citations: 12     Fields:    Translation:Animals
  42. Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem. 2012 Feb 10; 287(7):4518-30. PMID: 22158866.
    Citations: 19     Fields:    Translation:AnimalsCells
  43. Martín ED, Sánchez-Perez A, Trejo JL, Martin-Aldana JA, Cano Jaimez M, Pons S, Acosta Umanzor C, Menes L, White MF, Burks DJ. IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation. Cereb Cortex. 2012 Aug; 22(8):1717-27. PMID: 21955917.
    Citations: 33     Fields:    Translation:AnimalsCells
  44. Sadagurski M, Cheng Z, Rozzo A, Palazzolo I, Kelley GR, Dong X, Krainc D, White MF. IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. J Clin Invest. 2011 Oct; 121(10):4070-81. PMID: 21926467.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  45. Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 2011 Mar; 17(3):356-65. PMID: 21317886.
    Citations: 109     Fields:    Translation:AnimalsCells
  46. Long YC, Cheng Z, Copps KD, White MF. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Mol Cell Biol. 2011 Feb; 31(3):430-41. PMID: 21135130.
    Citations: 61     Fields:    Translation:AnimalsCells
  47. Wei D, Tao R, Zhang Y, White MF, Dong XC. Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. Am J Physiol Endocrinol Metab. 2011 Feb; 300(2):E312-20. PMID: 21081708.
    Citations: 19     Fields:    Translation:AnimalsCells
  48. Cheng Z, White MF. Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxid Redox Signal. 2011 Feb 15; 14(4):649-61. PMID: 20615072.
    Citations: 77     Fields:    Translation:HumansAnimals
  49. Cheng Z, Tseng Y, White MF. Insulin signaling meets mitochondria in metabolism. Trends Endocrinol Metab. 2010 Oct; 21(10):589-98. PMID: 20638297.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  50. Carew RM, Sadagurski M, Goldschmeding R, Martin F, White MF, Brazil DP. Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta? BMC Dev Biol. 2010 Jul 06; 10:73. PMID: 20604929.
    Citations: 8     Fields:    Translation:AnimalsCells
  51. Zaret KS, White MF. Diabetes forum: Extreme makeover of pancreatic alpha-cells. Nature. 2010 Apr 22; 464(7292):1132-3. PMID: 20414295.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  52. Cheng Z, White MF. Foxo1 in hepatic lipid metabolism. . 2010 Jan 15; 9(2):219-20. PMID: 20023377.
    Citations: 11     Translation:AnimalsCells
  53. Copps KD, Hancer NJ, Opare-Ado L, Qiu W, Walsh C, White MF. Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab. 2010 Jan; 11(1):84-92. PMID: 20074531.
    Citations: 91     Fields:    Translation:AnimalsCells
  54. Liang L, Guo WH, Esquiliano DR, Asai M, Rodriguez S, Giraud J, Kushner JA, White MF, Lopez MF. Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology. 2010 Feb; 151(2):741-7. PMID: 20032056.
    Citations: 9     Fields:    Translation:AnimalsCells
  55. Barbieri M, Rizzo MR, Papa M, Boccardi V, Esposito A, White MF, Paolisso G. The IRS2 Gly1057Asp variant is associated with human longevity. J Gerontol A Biol Sci Med Sci. 2010 Mar; 65(3):282-6. PMID: 19887537.
    Citations: 9     Fields:    Translation:HumansAnimals
  56. Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med. 2009 Nov; 15(11):1307-11. PMID: 19838201.
    Citations: 118     Fields:    Translation:AnimalsCells
  57. Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV, White MF. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol. 2009 Sep; 29(18):5070-83. PMID: 19596788.
    Citations: 60     Fields:    Translation:AnimalsCells
  58. Norquay LD, D'Aquino KE, Opare-Addo LM, Kuznetsova A, Haas M, Bluestone JA, White MF. Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology. 2009 Oct; 150(10):4531-40. PMID: 19574401.
    Citations: 11     Fields:    Translation:AnimalsCells
  59. White MF. Metformin and insulin meet in a most atypical way. Cell Metab. 2009 Jun; 9(6):485-7. PMID: 19490902.
    Citations: 7     Fields:    Translation:AnimalsCells
  60. Lee DH, Shi J, Jeoung NH, Kim MS, Zabolotny JM, Lee SW, White MF, Wei L, Kim YB. Targeted disruption of ROCK1 causes insulin resistance in vivo. J Biol Chem. 2009 May 01; 284(18):11776-80. PMID: 19276091.
    Citations: 57     Fields:    Translation:AnimalsCells
  61. Copps KD, White MF. Breathing room: the (un)natural history of adipose microhypoxia and insulin resistance. Diabetes. 2009 Jan; 58(1):26-7. PMID: 19114728.
    Citations:    Fields:    Translation:HumansAnimalsCells
  62. Szabolcs M, Keniry M, Simpson L, Reid LJ, Koujak S, Schiff SC, Davidian G, Licata S, Gruvberger-Saal S, Murty VV, Nandula S, Efstratiadis A, Kushner JA, White MF, Parsons R. Irs2 inactivation suppresses tumor progression in Pten+/- mice. Am J Pathol. 2009 Jan; 174(1):276-86. PMID: 19095950.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  63. Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI. Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes. 2008 Oct; 57(10):2644-51. PMID: 18633112.
    Citations: 37     Fields:    Translation:AnimalsCells
  64. Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008 Jul; 8(1):65-76. PMID: 18590693.
    Citations: 173     Fields:    Translation:AnimalsCells
  65. Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol. 2008 Mar; 15(3):251-8. PMID: 18278056.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  66. Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA. Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biol. 2008 Feb; 6(2):e37. PMID: 18288891.
    Citations: 53     Fields:    Translation:Animals
  67. Taguchi A, White MF. Insulin-like signaling, nutrient homeostasis, and life span. Annu Rev Physiol. 2008; 70:191-212. PMID: 17988211.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  68. Li D, Yin X, Zmuda EJ, Wolford CC, Dong X, White MF, Hai T. The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. Diabetes. 2008 Mar; 57(3):635-44. PMID: 18057093.
    Citations: 29     Fields:    Translation:AnimalsCells
  69. Sadagurski M, Nofech-Mozes S, Weingarten G, White MF, Kadowaki T, Wertheimer E. Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology. J Cell Physiol. 2007 Nov; 213(2):519-27. PMID: 17508357.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  70. Taguchi A, Wartschow LM, White MF. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science. 2007 Jul 20; 317(5836):369-72. PMID: 17641201.
    Citations: 228     Fields:    Translation:AnimalsCells
  71. Giraud J, Haas M, Feener EP, Copps KD, Dong X, Dunn SL, White MF. Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol Endocrinol. 2007 Sep; 21(9):2294-302. PMID: 17579213.
    Citations: 15     Fields:    Translation:AnimalsCells
  72. Kim JJ, Kido Y, Scherer PE, White MF, Accili D. Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1694-701. PMID: 17299086.
    Citations: 5     Fields:    Translation:AnimalsCells
  73. Gonzalez-Navarro H, Vila-Caballer M, Pastor MF, Vinue A, White MF, Burks D, Andres V. Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. Front Biosci. 2007 Jan 01; 12:2291-8. PMID: 17127239.
    Citations: 7     Fields:    Translation:AnimalsCells
  74. Ma Z, Gibson SL, Byrne MA, Zhang J, White MF, Shaw LM. Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Mol Cell Biol. 2006 Dec; 26(24):9338-51. PMID: 17030605.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  75. Guo S, Dunn SL, White MF. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Mol Endocrinol. 2006 Dec; 20(12):3389-99. PMID: 16916938.
    Citations: 24     Fields:    Translation:AnimalsCells
  76. White MF. Regulating insulin signaling and beta-cell function through IRS proteins. Can J Physiol Pharmacol. 2006 Jul; 84(7):725-37. PMID: 16998536.
    Citations: 69     Fields:    Translation:HumansCells
  77. Dong X, Park S, Lin X, Copps K, Yi X, White MF. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest. 2006 Jan; 116(1):101-14. PMID: 16374520.
    Citations: 73     Fields:    Translation:AnimalsCells
  78. Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L. RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem. 2006 Feb 03; 281(5):2649-53. PMID: 16326700.
    Citations: 103     Fields:    Translation:AnimalsCells
  79. Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M, Shulman GI. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest. 2005 Dec; 115(12):3587-93. PMID: 16284649.
    Citations: 287     Fields:    Translation:HumansCells
  80. Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G, White MF. Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem. 2006 Jan 13; 281(2):1159-68. PMID: 16272563.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  81. Kushner JA, Simpson L, Wartschow LM, Guo S, Rankin MM, Parsons R, White MF. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. J Biol Chem. 2005 Nov 25; 280(47):39388-93. PMID: 16170201.
    Citations: 14     Fields:    Translation:AnimalsCells
  82. Zhang Q, Carter EA, Ma BY, White M, Fischman AJ, Tompkins RG. Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation. Life Sci. 2005 Oct 28; 77(24):3068-77. PMID: 15982669.
    Citations: 17     Fields:    Translation:AnimalsCells
  83. Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol. 2005 May; 25(9):3752-62. PMID: 15831479.
    Citations: 167     Fields:    Translation:Animals
  84. Clough MH, Schneider DJ, Sobel BE, White MF, Wadsworth MP, Taatjes DJ. Attenuation of accumulation of neointimal lipid by pioglitazone in mice genetically deficient in insulin receptor substrate-2 and apolipoprotein E. J Histochem Cytochem. 2005 May; 53(5):603-10. PMID: 15872053.
    Citations: 10     Fields:    Translation:Animals
  85. Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E337-46. PMID: 15827066.
    Citations: 12     Fields:    Translation:AnimalsCells
  86. Sadagurski M, Weingarten G, Rhodes CJ, White MF, Wertheimer E. Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport. J Biol Chem. 2005 Apr 15; 280(15):14536-44. PMID: 15705592.
    Citations: 9     Fields:    Translation:AnimalsCells
  87. Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci. 2005 Feb 02; 25(5):1240-8. PMID: 15689562.
    Citations: 26     Fields:    Translation:AnimalsCells
  88. Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, Kido Y, Hayashi Y, Nakayama KI, White MF, Kasuga M. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med. 2005 Feb; 11(2):175-82. PMID: 15685168.
    Citations: 89     Fields:    Translation:AnimalsCells
  89. Fisher TL, White MF. Signaling pathways: the benefits of good communication. Curr Biol. 2004 Dec 14; 14(23):R1005-7. PMID: 15589136.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  90. Valverde AM, Fabregat I, Burks DJ, White MF, Benito M. IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology. 2004 Dec; 40(6):1285-94. PMID: 15565601.
    Citations: 17     Fields:    Translation:AnimalsCells
  91. Nagle JA, Ma Z, Byrne MA, White MF, Shaw LM. Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Mol Cell Biol. 2004 Nov; 24(22):9726-35. PMID: 15509777.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  92. Carter EA, Burks D, Fischman AJ, White M, Tompkins RG. Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue. Int J Mol Med. 2004 Oct; 14(4):653-8. PMID: 15375597.
    Citations: 17     Fields:    Translation:Animals
  93. Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, White MF. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest. 2004 Oct; 114(7):908-16. PMID: 15467829.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  94. Duan C, Yang H, White MF, Rui L. Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol. 2004 Sep; 24(17):7435-43. PMID: 15314154.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  95. Carlson CJ, White MF, Rondinone CM. Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem Biophys Res Commun. 2004 Apr 02; 316(2):533-9. PMID: 15020250.
    Citations: 48     Fields:    Translation:AnimalsCells
  96. Lee YH, White MF. Insulin receptor substrate proteins and diabetes. Arch Pharm Res. 2004 Apr; 27(4):361-70. PMID: 15180298.
    Citations: 38     Fields:    Translation:HumansAnimals
  97. Fujii N, Boppart MD, Dufresne SD, Crowley PF, Jozsi AC, Sakamoto K, Yu H, Aschenbach WG, Kim S, Miyazaki H, Rui L, White MF, Hirshman MF, Goodyear LJ. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. . 2004 Jul; 287(1):C200-8. PMID: 15013949.
    Citations: 22     Translation:HumansAnimalsCells
  98. Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF. Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes. 2004 Jan; 53(1):61-6. PMID: 14693698.
    Citations: 26     Fields:    Translation:AnimalsCells
  99. White MF. Insulin signaling in health and disease. Science. 2003 Dec 05; 302(5651):1710-1. PMID: 14657487.
    Citations: 183     Fields:    Translation:HumansAnimalsCells
  100. Giraud J, Leshan R, Lee YH, White MF. Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. J Biol Chem. 2004 Jan 30; 279(5):3447-54. PMID: 14623899.
    Citations: 33     Fields:    Translation:AnimalsCells
  101. Neid M, Datta K, Stephan S, Khanna I, Pal S, Shaw L, White M, Mukhopadhyay D. Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells. J Biol Chem. 2004 Feb 06; 279(6):3941-8. PMID: 14604996.
    Citations: 15     Fields:    Translation:HumansCells
  102. Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, Schubert M, Fisher TL, Dow MA, Leshan R, Zakaria M, Mossa-Basha M, White MF. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest. 2003 Nov; 112(10):1521-32. PMID: 14617753.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  103. Valverde AM, Burks DJ, Fabregat I, Fisher TL, Carretero J, White MF, Benito M. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes. 2003 Sep; 52(9):2239-48. PMID: 12941762.
    Citations: 42     Fields:    Translation:AnimalsCells
  104. Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci. 2003 Aug 06; 23(18):7084-92. PMID: 12904469.
    Citations: 158     Fields:    Translation:AnimalsCells
  105. Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 2003 Jul 01; 17(13):1575-80. PMID: 12842910.
    Citations: 180     Fields:    Translation:HumansAnimalsCells
  106. Arribas M, Valverde AM, Burks D, Klein J, Farese RV, White MF, Benito M. Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes. FEBS Lett. 2003 Feb 11; 536(1-3):161-6. PMID: 12586357.
    Citations: 2     Fields:    Translation:AnimalsCells
  107. Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC, Accili D. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest. 2002 Dec; 110(12):1839-47. PMID: 12488434.
    Citations: 226     Fields:    Translation:HumansAnimalsCells
  108. Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem. 2002 Dec 27; 277(52):50230-6. PMID: 12006582.
    Citations: 463     Fields:    Translation:AnimalsCells
  109. Chang Q, Li Y, White MF, Fletcher JA, Xiao S. Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications. Cancer Res. 2002 Nov 01; 62(21):6035-8. PMID: 12414625.
    Citations: 47     Fields:    Translation:HumansCells
  110. Lee YH, Giraud J, Davis RJ, White MF. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem. 2003 Jan 31; 278(5):2896-902. PMID: 12417588.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  111. Xuan S, Kitamura T, Nakae J, Politi K, Kido Y, Fisher PE, Morroni M, Cinti S, White MF, Herrera PL, Accili D, Efstratiadis A. Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest. 2002 Oct; 110(7):1011-9. PMID: 12370279.
    Citations: 70     Fields:    Translation:Animals
  112. Rui L, Yuan M, Frantz D, Shoelson S, White MF. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem. 2002 Nov 01; 277(44):42394-8. PMID: 12228220.
    Citations: 280     Fields:    Translation:HumansAnimals
  113. White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab. 2002 Sep; 283(3):E413-22. PMID: 12169433.
    Citations: 274     Fields:    Translation:HumansAnimalsCells
  114. Wurster AL, Rodgers VL, White MF, Rothstein TL, Grusby MJ. Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J Biol Chem. 2002 Jul 26; 277(30):27169-75. PMID: 12023955.
    Citations: 45     Fields:    Translation:AnimalsCells
  115. Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF. Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest. 2002 May; 109(9):1193-201. PMID: 11994408.
    Citations: 73     Fields:    Translation:AnimalsCells
  116. Howlett KF, Sakamoto K, Hirshman MF, Aschenbach WG, Dow M, White MF, Goodyear LJ. Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. Diabetes. 2002 Feb; 51(2):479-83. PMID: 11812758.
    Citations: 18     Fields:    Translation:AnimalsCells
  117. Xiao H, Yin T, Wang XY, Uchida T, Chung J, White MF, Yang YC. Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway. J Biol Chem. 2002 Mar 08; 277(10):8091-8. PMID: 11788580.
    Citations: 6     Fields:    Translation:AnimalsCells
  118. Wurster AL, Withers DJ, Uchida T, White MF, Grusby MJ. Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol Cell Biol. 2002 Jan; 22(1):117-26. PMID: 11739727.
    Citations: 30     Fields:    Translation:AnimalsCells
  119. Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem. 2002 Jan 11; 277(2):1531-7. PMID: 11606564.
    Citations: 284     Fields:    Translation:HumansAnimalsCells
  120. Withers DJ, White M. Perspective: The Insulin Signaling System-A Common Link in the Pathogenesis of Type 2 Diabetes. Endocrinology. 2000 Jun 01; 141(6):1917-1921. PMID: 28200913.
  121. Kim B, Leventhal PS, White MF, Feldman EL. Differential Regulation of Insulin Receptor Substrate-2 and Mitogen-Activated Protein Kinase Tyrosine Phosphorylation by Phosphatidylinositol 3-Kinase Inhibitors in SH-SY5Y Human Neuroblastoma Cells* * This work was supported by NIH Grants R29-NS-32843 and R01-NS-36778, grants from the American Diabetes Association and Juvenile Diabetes Foundation (to E.L.F.), and a grant from the Millie Schembechler Adrenal Research Fund of the University of Michigan Comprehensive Cancer Center (to E.L.F. and P.S.L.). Endocrinology. 1998 Dec 01; 139(12):4881-4889. PMID: 28200261.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.