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Darrick T Balu, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03AG063201 (BALU, DARRICK T) Sep 15, 2019 - May 31, 2021
    Defining the Role of Glial D-serine in Alzheimer's Disease
    Role: Principal Investigator
  2. R00MH099252 (BALU, DARRICK T) Aug 1, 2015 - Apr 30, 2018
    NMDA receptor hypofunction contributes to the dendritic dysplasia in schizophreni
    Role: Principal Investigator
  3. K99MH099252 (BALU, DARRICK T) Aug 5, 2013 - Jul 31, 2015
    NMDA receptor hypofunction contributes to the dendritic dysplasia in schizophreni
    Role: Principal Investigator
  4. F32MH090697 (BALU, DARRICK T) Apr 1, 2010 - Mar 31, 2012
    Molecular Mechanisms of Dendritic Abnormalities Related to D-Serine Deficiency
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tapanes SA, Arizanovska D, Díaz MM, Folorunso OO, Harvey T, Brown SE, Radzishevsky I, Close LN, Jagid JR, Graciolli Cordeiro J, Wolosker H, Balu DT, Liebl DJ. Inhibition of glial D-serine release rescues synaptic damage after brain injury. Glia. 2022 Jun; 70(6):1133-1152. PMID: 35195906.
    Citations:    Fields:    
  2. Aguilar DD, Radzik LK, Schiffino FL, Folorunso OO, Zielinski MR, Coyle JT, Balu DT, McNally JM. Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunction. Sci Rep. 2021 04 27; 11(1):9031. PMID: 33907230.
    Citations: 4     Fields:    Translation:Animals
  3. Folorunso OO, Harvey TL, Brown SE, Cruz C, Shahbo E, Ajjawi I, Balu DT. Forebrain expression of serine racemase during postnatal development. Neurochem Int. 2021 05; 145:104990. PMID: 33592203.
    Citations:    Fields:    Translation:Animals
  4. Coyle JT, Ruzicka WB, Balu DT. Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse. Am J Psychiatry. 2020 12 01; 177(12):1119-1128. PMID: 33256439.
    Citations: 5     Fields:    Translation:HumansCells
  5. Takagi S, Balu DT, Coyle JT. Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum. Brain Res. 2021 01 15; 1751:147202. PMID: 33171153.
    Citations: 2     Fields:    Translation:Animals
  6. Wong JM, Folorunso OO, Barragan EV, Berciu C, Harvey TL, Coyle JT, Balu DT, Gray JA. Postsynaptic Serine Racemase Regulates NMDA Receptor Function. J Neurosci. 2020 12 09; 40(50):9564-9575. PMID: 33158959.
    Citations: 6     Fields:    Translation:AnimalsCells
  7. Wolosker H, Balu DT. D-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders. Transl Psychiatry. 2020 06 09; 10(1):184. PMID: 32518273.
    Citations: 9     Fields:    Translation:Humans
  8. Takagi S, Puhl MD, Anderson T, Balu DT, Coyle JT. Serine Racemase Expression by Striatal Neurons. Cell Mol Neurobiol. 2022 Jan; 42(1):279-289. PMID: 32445040.
    Citations: 3     Fields:    
  9. Coyle JT, Balu D, Wolosker H. D-Serine, the Shape-Shifting NMDA Receptor Co-agonist. Neurochem Res. 2020 Jun; 45(6):1344-1353. PMID: 32189130.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  10. Balu DT, Pantazopoulos H, Huang CCY, Muszynski K, Harvey TL, Uno Y, Rorabaugh JM, Galloway CR, Botz-Zapp C, Berretta S, Weinshenker D, Coyle JT. Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease. Neurobiol Dis. 2019 10; 130:104511. PMID: 31212068.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  11. Huang CCY, Muszynski KJ, Bolshakov VY, Balu DT. Deletion of Dtnbp1 in mice impairs threat memory consolidation and is associated with enhanced inhibitory drive in the amygdala. Transl Psychiatry. 2019 04 09; 9(1):132. PMID: 30967545.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathol. 2018 10; 136(4):537-555. PMID: 29982852.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  13. Keller S, Punzo D, Cuomo M, Affinito O, Coretti L, Sacchi S, Florio E, Lembo F, Carella M, Copetti M, Cocozza S, Balu DT, Errico F, Usiello A, Chiariotti L. DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia. Sci Rep. 2018 07 05; 8(1):10163. PMID: 29976992.
    Citations: 15     Fields:    Translation:HumansCells
  14. Konopaske GT, Balu DT, Presti KT, Chan G, Benes FM, Coyle JT. Dysbindin-1 contributes to prefrontal cortical dendritic arbor pathology in schizophrenia. Schizophr Res. 2018 11; 201:270-277. PMID: 29759351.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  15. Li S, Uno Y, Rudolph U, Cobb J, Liu J, Anderson T, Levy D, Balu DT, Coyle JT. Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features. Biochem Pharmacol. 2018 05; 151:245-251. PMID: 29305854.
    Citations: 14     Fields:    Translation:AnimalsCells
  16. Coyle JT, Balu DT. The Role of Serine Racemase in the Pathophysiology of Brain Disorders. Adv Pharmacol. 2018; 82:35-56. PMID: 29413527.
    Citations: 15     Fields:    Translation:HumansAnimals
  17. Balu DT, Coyle JT. Altered CREB Binding to Activity-Dependent Genes in Serine Racemase Deficient Mice, a Mouse Model of Schizophrenia. ACS Chem Neurosci. 2018 09 19; 9(9):2205-2209. PMID: 29172439.
    Citations: 1     Fields:    Translation:Animals
  18. Balu DT, Presti KT, Huang CCY, Muszynski K, Radzishevsky I, Wolosker H, Guffanti G, Ressler KJ, Coyle JT. Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning. Biol Psychiatry. 2018 02 01; 83(3):273-283. PMID: 29025687.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  19. Wolosker H, Balu DT, Coyle JT. Astroglial Versus Neuronal D-Serine: Check Your Controls! Trends Neurosci. 2017 09; 40(9):520-522. PMID: 28756007.
    Citations: 13     Fields:    Translation:HumansCells
  20. Perez EJ, Tapanes SA, Loris ZB, Balu DT, Sick TJ, Coyle JT, Liebl DJ. Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury. J Clin Invest. 2017 Aug 01; 127(8):3114-3125. PMID: 28714867.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  21. Balu DT. Cognitive Deficits in Prematurely Born Adults Are Associated With Reduced Basal Forebrain Integrity. Biol Psychiatry. 2017 07 15; 82(2):e15-e16. PMID: 28645360.
    Citations: 1     Fields:    Translation:Humans
  22. Wolosker H, Balu DT, Coyle JT. The Rise and Fall of the d-Serine-Mediated Gliotransmission Hypothesis. Trends Neurosci. 2016 11; 39(11):712-721. PMID: 27742076.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  23. Balu DT. The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment. Adv Pharmacol. 2016; 76:351-82. PMID: 27288082.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  24. Coyle JT, Balu DT, Puhl MD, Konopaske GT. History of the Concept of Disconnectivity in Schizophrenia. Harv Rev Psychiatry. 2016 Mar-Apr; 24(2):80-6. PMID: 26954593.
    Citations: 12     Fields:    Translation:HumansCells
  25. Balu D, Ouyang J, Parakhia RA, Pitake S, Ochs RS. Ca2+ effects on glucose transport and fatty acid oxidation in L6 skeletal muscle cell cultures. Biochem Biophys Rep. 2016 Mar; 5:365-373. PMID: 28955844.
    Citations: 1     
  26. Balu DT, Li Y, Takagi S, Presti KT, Ramikie TS, Rook JM, Jones CK, Lindsley CW, Conn PJ, Bolshakov VY, Coyle JT. An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia. Neuropsychopharmacology. 2016 07; 41(8):2052-61. PMID: 26741285.
    Citations: 25     Fields:    Translation:AnimalsCells
  27. Ishiwata S, Balu DT, Umino A, Coyle JT, Nishikawa T. [JSNP Excellent Presentation Award for CINP2014]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2015 Apr; 35(2):53-4. PMID: 26027070.
    Citations:    Fields:    Translation:AnimalsCells
  28. Ishiwata S, Umino A, Balu DT, Coyle JT, Nishikawa T. Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus. J Neural Transm (Vienna). 2015 Aug; 122(8):1099-103. PMID: 25782690.
    Citations: 11     Fields:    Translation:AnimalsCells
  29. Takagi S, Balu DT, Coyle JT. Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice. Schizophr Res. 2015 Mar; 162(1-3):216-21. PMID: 25592804.
    Citations: 6     Fields:    Translation:AnimalsCells
  30. Balu DT, Coyle JT. The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond. Curr Opin Pharmacol. 2015 Feb; 20:109-15. PMID: 25540902.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  31. Balu DT, Coyle JT. Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction. Neurochem Int. 2014 Sep; 75:76-8. PMID: 24915645.
    Citations: 18     Fields:    Translation:Animals
  32. Balu DT, Takagi S, Puhl MD, Benneyworth MA, Coyle JT. D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain. Cell Mol Neurobiol. 2014 Apr; 34(3):419-35. PMID: 24436034.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  33. Santini MA, Balu DT, Puhl MD, Hill-Smith TE, Berg AR, Lucki I, Mikkelsen JD, Coyle JT. D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI. Behav Brain Res. 2014 Feb 01; 259:242-6. PMID: 24269270.
    Citations: 2     Fields:    Translation:Animals
  34. Balu DT, Li Y, Puhl MD, Benneyworth MA, Basu AC, Takagi S, Bolshakov VY, Coyle JT. Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2400-9. PMID: 23729812.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  35. Balu DT, Turner JR, Brookshire BR, Hill-Smith TE, Blendy JA, Lucki I. Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice. Neuropharmacology. 2013 Apr; 67:503-10. PMID: 23220293.
    Citations: 5     Fields:    Translation:Animals
  36. Balu DT, Coyle JT. Neuronal D-serine regulates dendritic architecture in the somatosensory cortex. Neurosci Lett. 2012 May 31; 517(2):77-81. PMID: 22521586.
    Citations: 27     Fields:    Translation:AnimalsCells
  37. Coyle JT, Basu A, Benneyworth M, Balu D, Konopaske G. Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications. Handb Exp Pharmacol. 2012; (213):267-95. PMID: 23027419.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  38. Balu DT, Basu AC, Corradi JP, Cacace AM, Coyle JT. The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex. Neurobiol Dis. 2012 Feb; 45(2):671-82. PMID: 22024716.
    Citations: 44     Fields:    Translation:AnimalsCells
  39. Ho N, Balu DT, Hilario MR, Blendy JA, Lucki I. Depressive phenotypes evoked by experimental diabetes are reversed by insulin. Physiol Behav. 2012 Feb 01; 105(3):702-8. PMID: 21945451.
    Citations: 19     Fields:    Translation:Animals
  40. Balu DT, Coyle JT. Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction. Brain Res. 2011 May 25; 1392:1-7. PMID: 21443867.
    Citations: 20     Fields:    Translation:AnimalsCells
  41. Balu DT, Carlson GC, Talbot K, Kazi H, Hill-Smith TE, Easton RM, Birnbaum MJ, Lucki I. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus. 2012 Feb; 22(2):230-40. PMID: 21049487.
    Citations: 38     Fields:    Translation:HumansAnimals
  42. DeVito LM, Balu DT, Kanter BR, Lykken C, Basu AC, Coyle JT, Eichenbaum H. Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology. Genes Brain Behav. 2011 Mar; 10(2):210-22. PMID: 21029376.
    Citations: 58     Fields:    Translation:AnimalsCells
  43. Balu DT, Coyle JT. Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci Biobehav Rev. 2011 Jan; 35(3):848-70. PMID: 20951727.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  44. Balu DT. Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of acute and chronic antidepressant treatments. Exp Clin Psychopharmacol. 2010 Feb; 18(1):71-7. PMID: 20158296.
    Citations: 5     Fields:    Translation:Animals
  45. Coyle JT, Balu D, Benneyworth M, Basu A, Roseman A. Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia. Dialogues Clin Neurosci. 2010; 12(3):359-82. PMID: 20954431.
    Citations: 27     Fields:    Translation:HumansAnimals
  46. Balu DT, Hodes GE, Anderson BT, Lucki I. Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of chronic antidepressant treatments. Neuropsychopharmacology. 2009 Jun; 34(7):1764-73. PMID: 19177066.
    Citations: 37     Fields:    Translation:AnimalsCells
  47. Balu DT, Hodes GE, Hill TE, Ho N, Rahman Z, Bender CN, Ring RH, Dwyer JM, Rosenzweig-Lipson S, Hughes ZA, Schechter LE, Lucki I. Flow cytometric analysis of BrdU incorporation as a high-throughput method for measuring adult neurogenesis in the mouse. J Pharmacol Toxicol Methods. 2009 Mar-Apr; 59(2):100-7. PMID: 19121403.
    Citations: 23     Fields:    Translation:AnimalsCells
  48. Balu DT, Lucki I. Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology. Neurosci Biobehav Rev. 2009 Mar; 33(3):232-52. PMID: 18786562.
    Citations: 133     Fields:    Translation:HumansAnimalsCells
  49. Balu DT, Hoshaw BA, Malberg JE, Rosenzweig-Lipson S, Schechter LE, Lucki I. Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain Res. 2008 May 23; 1211:37-43. PMID: 18433734.
    Citations: 71     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.