Harvard Catalyst Profiles

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Gregory Crosby, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AG061696 (CROSBY, GREGORY) Feb 15, 2019 - Nov 30, 2020
    NIH/NIA
    Circulating Extracellular Vesicles as Biomarkers of Postoperative Delirium
    Role: Principal Investigator
  2. R01AG051812 (CROSBY, GREGORY) Sep 15, 2016 - Apr 30, 2021
    NIH/NIA
    Microglial mechanisms of postoperative CNS inflammation and cognitive decline
    Role: Co-Principal Investigator
  3. R21AG048637 (CROSBY, GREGORY) Sep 1, 2014 - May 31, 2016
    NIH/NIA
    Role of ABeta in neural synapse and circuit remodeling following general anesthes
    Role: Principal Investigator
  4. R01GM088817 (CROSBY, GREGORY) Apr 1, 2003 - Mar 31, 2014
    NIH/NIGMS
    Crosby_Gregory_Mechanisms of Post-Anesthetic CNS Dysfunction in Aging
    Role: Principal Investigator
  5. R01AG020253 (CROSBY, GREGORY) Apr 1, 2003 - Mar 31, 2008
    NIH/NIA
    Mechanisms of Post-Anesthetic CNS Dysfunction in Aging
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Susano MJ, Crosby G, Culley DJ. Response to Letter to the Editor From Lobo et al. J Neurosurg Anesthesiol. 2019 Jul 02. PMID: 31274671.
    Citations:    
  2. Crosby G. To Changing Your Mind. Anesth Analg. 2019 Apr; 128(4):615-616. PMID: 30883413.
    Citations:    
  3. Friese MB, Nathan M, Culley DJ, Crosby G. Isoflurane anesthesia impairs the expression of immune neuromodulators in the hippocampus of aged mice. PLoS One. 2018; 13(12):e0209283. PMID: 30571762.
    Citations:    Fields:    
  4. Susano MJ, Scheetz SD, Grasfield RH, Cheung D, Xu X, Kang JD, Smith TR, Lu Y, Groff MW, Chi JH, Crosby G, Culley DJ. Retrospective Analysis of Perioperative Variables Associated With Postoperative Delirium and Other Adverse Outcomes in Older Patients After Spine Surgery. J Neurosurg Anesthesiol. 2018 Dec 07. PMID: 30531557.
    Citations:    Fields:    
  5. Crosby G. Publishing Methods Without Results: A First That Hopefully Will Not Last. Anesth Analg. 2018 May; 126(5):1444-1445. PMID: 29672382.
    Citations:    Fields:    
  6. Palanisamy A, Kannappan R, Xu Z, Martino A, Friese MB, Boyd JD, Crosby G, Culley DJ. Oxytocin alters cell fate selection of rat neural progenitor cells in vitro. PLoS One. 2018; 13(1):e0191160. PMID: 29346405.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Palanisamy A, Crosby G, Culley DJ. EARLY gestational exposure to isoflurane causes persistent cell loss in the dentate gyrus of adult male rats. Behav Brain Funct. 2017 Dec 26; 13(1):14. PMID: 29279051.
    Citations:    Fields:    Translation:AnimalsCells
  8. Culley DJ, Flaherty D, Fahey MC, Rudolph JL, Javedan H, Huang CC, Wright J, Bader AM, Hyman BT, Blacker D, Crosby G. Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients. Anesthesiology. 2017 11; 127(5):765-774. PMID: 28891828.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  9. Miao H, Dong Y, Zhang Y, Zheng H, Shen Y, Crosby G, Culley DJ, Marcantonio ER, Xie Z. Anesthetic Isoflurane or Desflurane Plus Surgery Differently Affects Cognitive Function in Alzheimer's Disease Transgenic Mice. Mol Neurobiol. 2018 Jul; 55(7):5623-5638. PMID: 28986748.
    Citations:    Fields:    
  10. Crosby G, Muir KW. Anesthesia and neurologic outcome of endovascular therapy in acute ischemic stroke: MR (not so) CLEAN. Neurology. 2016 08 16; 87(7):648-9. PMID: 27421540.
    Citations: 1     Fields:    Translation:Humans
  11. Palanisamy A, Friese MB, Cotran E, Moller L, Boyd JD, Crosby G, Culley DJ. Prolonged Treatment with Propofol Transiently Impairs Proliferation but Not Survival of Rat Neural Progenitor Cells In Vitro. PLoS One. 2016; 11(7):e0158058. PMID: 27379684.
    Citations: 4     Fields:    Translation:AnimalsCells
  12. Culley DJ, Flaherty D, Reddy S, Fahey MC, Rudolph J, Huang CC, Liu X, Xie Z, Bader AM, Hyman BT, Blacker D, Crosby G. Preoperative Cognitive Stratification of Older Elective Surgical Patients: A Cross-Sectional Study. Anesth Analg. 2016 07; 123(1):186-92. PMID: 27028776.
    Citations: 4     Fields:    Translation:Humans
  13. Culley DJ, Crosby G. Dementia after Cardiac Surgery: Is It the Procedure or the Patient? Anesthesiology. 2016 07; 125(1):14-6. PMID: 27127918.
    Citations: 1     Fields:    Translation:Humans
  14. Englert JA, Macias AA, Amador-Munoz D, Pinilla Vera M, Isabelle C, Guan J, Magaoay B, Suarez Velandia M, Coronata A, Lee A, Fredenburgh LE, Culley DJ, Crosby G, Baron RM. Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity. Anesthesiology. 2015 Aug; 123(2):377-88. PMID: 26068207.
    Citations: 10     Fields:    Translation:AnimalsCells
  15. Culley DJ, Crosby G. Prehabilitation for Prevention of Postoperative Cognitive Dysfunction? Anesthesiology. 2015 Jul; 123(1):7-9. PMID: 26001030.
    Citations: 1     Fields:    Translation:Animals
  16. Tao G, Zhang J, Zhang L, Dong Y, Yu B, Crosby G, Culley DJ, Zhang Y, Xie Z. Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3ß activation in young mice. Anesthesiology. 2014 Sep; 121(3):510-27. PMID: 24787352.
    Citations: 17     Fields:    Translation:AnimalsCells
  17. Culley DJ, Snayd M, Baxter MG, Xie Z, Lee IH, Rudolph J, Inouye SK, Marcantonio ER, Crosby G. Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. Front Aging Neurosci. 2014; 6:107. PMID: 24959140.
    Citations: 13     
  18. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Peripheral surgical wounding and age-dependent neuroinflammation in mice. PLoS One. 2014; 9(5):e96752. PMID: 24796537.
    Citations: 14     Fields:    Translation:Animals
  19. Crosby G, Culley DJ, Dexter F. Cognitive outcome of surgery: is there no place like home? Anesth Analg. 2014 May; 118(5):898-900. PMID: 24781557.
    Citations: 2     Fields:    Translation:Humans
  20. Zhang Y, Pan C, Wu X, Dong Y, Culley DJ, Crosby G, Li T, Xie Z. Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons. Front Cell Neurosci. 2014; 8:14. PMID: 24523673.
    Citations: 3     
  21. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Sci Rep. 2014 Jan 20; 4:3766. PMID: 24441878.
    Citations: 26     Fields:    Translation:HumansAnimals
  22. Culley DJ, Fahy BG, Xie Z, Lekowski R, Buetler S, Liu X, Cohen NH, Crosby G. Academic productivity of directors of ACGME-accredited residency programs in surgery and anesthesiology. Anesth Analg. 2014 Jan; 118(1):200-5. PMID: 24247229.
    Citations:    Fields:    Translation:Humans
  23. Crosby G, Davis PJ. General anesthesia in infancy is associated with learning disabilities-or not. Anesth Analg. 2013 Dec; 117(6):1270-2. PMID: 24132014.
    Citations: 3     Fields:    Translation:Humans
  24. Zheng H, Dong Y, Xu Z, Crosby G, Culley DJ, Zhang Y, Xie Z. Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice. Anesthesiology. 2013 Mar; 118(3):516-26. PMID: 23314109.
    Citations: 40     Fields:    Translation:Animals
  25. Mashour GA, Avitsian R, Lauer KK, Soriano SG, Sharma D, Koht A, Crosby G. Neuroanesthesiology fellowship training: curricular guidelines from the Society for Neuroscience in Anesthesiology and Critical Care. J Neurosurg Anesthesiol. 2013 Jan; 25(1):1-7. PMID: 23171854.
    Citations: 1     Fields:    Translation:Humans
  26. Crosby G, Culley DJ. Anesthesia & analgesia by the numbers: then & now. Anesth Analg. 2012 Dec; 115(6):1265-7. PMID: 23175575.
    Citations:    Fields:    Translation:Humans
  27. Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol. 2012 May; 71(5):687-98. PMID: 22368036.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  28. Crosby G, Culley DJ. Processed electroencephalogram and depth of anesthesia: window to nowhere or into the brain? Anesthesiology. 2012 Feb; 116(2):235-7. PMID: 22222481.
    Citations: 3     Fields:    Translation:Humans
  29. Culley DJ, Maze M, Crosby G. Reprogramming of the infant brain by surgery with general anesthesia. Mayo Clin Proc. 2012 Feb; 87(2):110-3. PMID: 22305023.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  30. Thomas J, Crosby G, Drummond JC, Todd M. Anesthetic neurotoxicity: a difficult dragon to slay. Anesth Analg. 2011 Nov; 113(5):969-71. PMID: 22021792.
    Citations:    Fields:    Translation:Humans
  31. Culley DJ, Boyd JD, Palanisamy A, Xie Z, Kojima K, Vacanti CA, Tanzi RE, Crosby G. Isoflurane decreases self-renewal capacity of rat cultured neural stem cells. Anesthesiology. 2011 Oct; 115(4):754-63. PMID: 21666433.
    Citations: 24     Fields:    Translation:AnimalsCells
  32. Palanisamy A, Crosby G, Culley DJ. In reply. Anesthesiology. 2011 Oct; 115(4):904-5. PMID: 21934420.
    Citations:    
  33. Crosby G, Culley DJ, Hyman BT. Preoperative cognitive assessment of the elderly surgical patient: a call for action. Anesthesiology. 2011 Jun; 114(6):1265-8. PMID: 21490501.
    Citations: 9     Fields:    Translation:Humans
  34. Crosby G, Culley DJ. Surgery and anesthesia: healing the body but harming the brain? Anesth Analg. 2011 May; 112(5):999-1001. PMID: 21515644.
    Citations: 3     Fields:    Translation:Humans
  35. Palanisamy A, Baxter MG, Keel PK, Xie Z, Crosby G, Culley DJ. Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. Anesthesiology. 2011 Mar; 114(3):521-8. PMID: 21307768.
    Citations: 27     Fields:    Translation:Animals
  36. Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-a, IL-6, and IL-1ß. Neurobiol Aging. 2012 Jul; 33(7):1364-78. PMID: 21190757.
    Citations: 69     Fields:    Translation:AnimalsCells
  37. Crosby G, Culley DJ, Patel PM. At the sharp end of spines: anesthetic effects on synaptic remodeling in the developing brain. Anesthesiology. 2010 Mar; 112(3):521-3. PMID: 20124984.
    Citations: 2     Fields:    Translation:HumansCells
  38. Crosby G, Culley DJ, Marcantonio ER. Delirium: a cognitive cost of the comfort of procedural sedation in elderly patients? Mayo Clin Proc. 2010 Jan; 85(1):12-4. PMID: 20042555.
    Citations: 1     Fields:    Translation:Humans
  39. Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol. 2009 May; 66(5):620-31. PMID: 19433662.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  40. Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol. 2008 Dec; 64(6):618-27. PMID: 19006075.
    Citations: 103     Fields:    Translation:AnimalsCells
  41. Lee IH, Culley DJ, Baxter MG, Xie Z, Tanzi RE, Crosby G. Spatial memory is intact in aged rats after propofol anesthesia. Anesth Analg. 2008 Oct; 107(4):1211-5. PMID: 18806029.
    Citations: 10     Fields:    Translation:Animals
  42. Marcantonio ER, Aneja J, Jones RN, Alsop DC, Fong TG, Crosby GJ, Culley DJ, Cupples LA, Inouye SK. Maximizing clinical research participation in vulnerable older persons: identification of barriers and motivators. J Am Geriatr Soc. 2008 Aug; 56(8):1522-7. PMID: 18662204.
    Citations: 16     Fields:    Translation:Humans
  43. Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci. 2008 Apr 23; 28(17):4551-60. PMID: 18434534.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  44. Culley DJ, Crosby G. Nitrous oxide in neuroanesthesia: tried and true or toxin? Anesthesiology. 2008 Apr; 108(4):553-4. PMID: 18362583.
    Citations:    Fields:    Translation:Humans
  45. Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem. 2008 May 02; 283(18):11866-75. PMID: 18326038.
    Citations: 35     Fields:    Translation:HumansCells
  46. Baxter MG, Murphy KL, Crosby G, Culley DJ. Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia. Hippocampus. 2008; 18(3):245-50. PMID: 18058823.
    Citations: 1     Fields:    Translation:Animals
  47. Culley DJ, Xie Z, Crosby G. General anesthetic-induced neurotoxicity: an emerging problem for the young and old? Curr Opin Anaesthesiol. 2007 Oct; 20(5):408-13. PMID: 17873593.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  48. Culley DJ, Raghavan SV, Waly M, Baxter MG, Yukhananov R, Deth RC, Crosby G. Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats. Anesth Analg. 2007 Jul; 105(1):83-8. PMID: 17578961.
    Citations: 9     Fields:    Translation:Animals
  49. Culley DJ, Crosby G, Xie Z, Vacanti CA, Kitz RJ, Zapol WM. Career National Institutes of Health funding and scholarship of chairpersons of academic departments of anesthesiology and surgery. Anesthesiology. 2007 Apr; 106(4):836-42. PMID: 17413922.
    Citations: 2     Fields:    Translation:Humans
  50. Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci. 2007 Feb 07; 27(6):1247-54. PMID: 17287498.
    Citations: 86     Fields:    Translation:HumansCells
  51. Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1300-6. PMID: 17234824.
    Citations: 48     Fields:    Translation:HumansCells
  52. Marcantonio ER, Rudolph JL, Culley D, Crosby G, Alsop D, Inouye SK. Serum biomarkers for delirium. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1281-6. PMID: 17234821.
    Citations: 28     Fields:    Translation:Humans
  53. Culley DJ, Yukhananov RY, Xie Z, Gali RR, Tanzi RE, Crosby G. Altered hippocampal gene expression 2 days after general anesthesia in rats. Eur J Pharmacol. 2006 Nov 07; 549(1-3):71-8. PMID: 16979155.
    Citations: 12     Fields:    Translation:Animals
  54. Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology. 2006 May; 104(5):988-94. PMID: 16645451.
    Citations: 85     Fields:    Translation:HumansCells
  55. Culley DJ, Loguinov A, Yukhananov R, Crosby G. General anesthesia does not reduce life expectancy in aged rats. Anesth Analg. 2006 Mar; 102(3):956-9. PMID: 16492858.
    Citations: 2     Fields:    Translation:Animals
  56. Crosby C, Culley DJ, Baxter MG, Yukhananov R, Crosby G. Spatial memory performance 2 weeks after general anesthesia in adult rats. Anesth Analg. 2005 Nov; 101(5):1389-92. PMID: 16243999.
    Citations: 19     Fields:    Translation:Animals
  57. Culley DJ, Baxter MG, Crosby CA, Yukhananov R, Crosby G. Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats. Anesth Analg. 2004 Nov; 99(5):1393-7; table of contents. PMID: 15502036.
    Citations: 47     Fields:    Translation:Animals
  58. Lee IO, Yukhananov R, Standaert DG, Crosby G. NMDA-R1 antisense oligodeoxynucleotides modify formalin-induced nociception and spinal c-Fos expression in rat spinal cord. Pharmacol Biochem Behav. 2004 Sep; 79(1):183-8. PMID: 15388298.
    Citations: 6     Fields:    Translation:Animals
  59. Tran T, Culley DJ, Crosby G. Hemorrhagic stroke after spinal anesthesia and minor surgery. J Clin Anesth. 2004 Jun; 16(4):293-5. PMID: 15261323.
    Citations:    Fields:    Translation:Humans
  60. Kaplan A, Crosby GJ, Bhattacharyya N. Airway protection and the laryngeal mask airway in sinus and nasal surgery. Laryngoscope. 2004 Apr; 114(4):652-5. PMID: 15064618.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  61. Culley DJ, Baxter MG, Yukhananov R, Crosby G. Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats. Anesthesiology. 2004 Feb; 100(2):309-14. PMID: 14739805.
    Citations: 95     Fields:    Translation:Animals
  62. Crosby G. Neuroanesthesia practice standards: we need data, not dogma. J Neurosurg Anesthesiol. 2003 Oct; 15(4):337-40. PMID: 14508179.
    Citations: 1     Fields:    Translation:Humans
  63. Culley DJ, Crosby G. Mechanisms of postoperative neurobehavioral deficits and stroke may differ. Anesth Analg. 2003 Aug; 97(2):601; author reply 601. PMID: 12873962.
    Citations:    Fields:    Translation:Humans
  64. Culley DJ, Baxter M, Yukhananov R, Crosby G. The memory effects of general anesthesia persist for weeks in young and aged rats. Anesth Analg. 2003 Apr; 96(4):1004-9, table of contents. PMID: 12651650.
    Citations: 74     Fields:    Translation:Animals
  65. Yukhananov R, Guan J, Crosby G. Antisense oligonucleotides to N-methyl-D-aspartate receptor subunits attenuate formalin-induced nociception in the rat. Brain Res. 2002 Mar 15; 930(1-2):163-9. PMID: 11879806.
    Citations: 4     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.