Harvard Catalyst Profiles

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Shelley Irwin Fried, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS110575 (FRIED, SHELLEY) Jun 15, 2019 - May 31, 2023
    Investigating the response of CNS neurons to electric and magnetic stimulation
    Role: Principal Investigator
  2. U01NS099700 (FRIED, SHELLEY) Sep 30, 2016 - Jun 30, 2021
    Micro-coil implants for cortical activation
    Role: Principal Investigator
  3. I01RX001663 (FRIED, SHELLEY) Jan 1, 2015 - Dec 31, 2017
    Towards improved efficacy of retinal prosthetics
    Role: Principal Investigator
  4. R01EY023651 (FRIED, SHELLEY) Sep 1, 2013 - Jul 31, 2018
    HRS targeting of ON and OFF ganglion cells
    Role: Principal Investigator
  5. I01RX000350 (FRIED, SHELLEY) Apr 1, 2011 - Mar 31, 2014
    Informing the Sub-Retinal Approach to Stimualation of the Retina.
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Paulk AC, Yang JC, Cleary DR, Soper DJ, Halgren M, O'Donnell AR, Lee SH, Ganji M, Ro YG, Oh H, Hossain L, Lee J, Tchoe Y, Rogers N, Kiliç K, Ryu SB, Lee SW, Hermiz J, Gilja V, Ulbert I, Fabó D, Thesen T, Doyle WK, Devinsky O, Madsen JR, Schomer DL, Eskandar EN, Lee JW, Maus D, Devor A, Fried SI, Jones PS, Nahed BV, Ben-Haim S, Bick SK, Richardson RM, Raslan AM, Siler DA, Cahill DP, Williams ZM, Cosgrove GR, Dayeh SA, Cash SS. Microscale Physiological Events on the Human Cortical Surface. Cereb Cortex. 2021 Jul 05; 31(8):3678-3700. PMID: 33749727.
    Citations:    Fields:    
  2. Moleirinho S, Whalen AJ, Fried SI, Pezaris JS. The impact of synchronous versus asynchronous electrical stimulation in artificial vision. J Neural Eng. 2021 04 27; 18(5). PMID: 33900206.
    Citations:    Fields:    Translation:Cells
  3. Urdaneta ME, Kunigk NG, Delgado F, Fried SI, Otto KJ. Layer-specific parameters of intracortical microstimulation of the somatosensory cortex. J Neural Eng. 2021 04 14; 18(5). PMID: 33706301.
    Citations:    Fields:    Translation:HumansAnimals
  4. Ryu SB, Paulk AC, Yang JC, Ganji M, Dayeh SA, Cash SS, Fried SI, Lee SW. Spatially confined responses of mouse visual cortex to intracortical magnetic stimulation from micro-coils. J Neural Eng. 2020 10 23; 17(5):056036. PMID: 32998116.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Werginz P, Raghuram V, Fried SI. Tailoring of the axon initial segment shapes the conversion of synaptic inputs into spiking output in OFF-a T retinal ganglion cells. Sci Adv. 2020 Sep; 6(37). PMID: 32917708.
    Citations: 3     Fields:    
  6. Werginz P, Raghuram V, Fried SI. The relationship between morphological properties and thresholds to extracellular electric stimulation in a RGCs. J Neural Eng. 2020 08 27; 17(4):045015. PMID: 32736374.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Muralidharan M, Guo T, Shivdasani MN, Tsai D, Fried S, Li L, Dokos S, Morley JW, Lovell NH. Neural activity of functionally different retinal ganglion cells can be robustly modulated by high-rate electrical pulse trains. J Neural Eng. 2020 08 04; 17(4):045013. PMID: 32512555.
    Citations: 1     Fields:    Translation:Cells
  8. Muralidharan M, Guo T, Shivdasani MN, Tsai D, Fried S, Cameron M, Morley JW, Dokos S, Lovell NH. Towards Controlling Functionally-Distinct Retinal Ganglion Cells In Degenerate Retina. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:3598-3601. PMID: 33018781.
    Citations:    Translation:HumansCells
  9. Lee JI, Hadjinicolaou AE, Fried SI. Response Profiles of Retinal Ganglion Cells to Sinusoidal Electric Stimulation vary for Low vs. High Frequencies. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:3533-3536. PMID: 33018766.
    Citations:    Translation:HumansCells
  10. Hadjinicolaou AE, Werginz P, Lee JI, Fried SI. Differential Responses to High-Frequency Electrical Stimulation in Brisk-Transient and Delta Retinal Ganglion Cells. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:3529-3532. PMID: 33018765.
    Citations:    Translation:HumansCells
  11. Yoon YJ, Lee JI, Jang YJ, An S, Kim JH, Fried SI, Im M. Retinal Degeneration Reduces Consistency of Network-Mediated Responses Arising in Ganglion Cells to Electric Stimulation. IEEE Trans Neural Syst Rehabil Eng. 2020 09; 28(9):1921-1930. PMID: 32746297.
    Citations: 2     Fields:    Translation:Animals
  12. Yu H, Enayati S, Chang K, Cho K, Lee SW, Talib M, Zihlavnikova K, Xie J, Achour H, Fried SI, Utheim TP, Chen DF. Noninvasive Electrical Stimulation Improves Photoreceptor Survival and Retinal Function in Mice with Inherited Photoreceptor Degeneration. Invest Ophthalmol Vis Sci. 2020 04 09; 61(4):5. PMID: 32271885.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Fried SI, Shivdasani MN. Selective activation of the visual cortex. Nat Biomed Eng. 2020 02; 4(2):139-141. PMID: 32051575.
    Citations:    Fields:    
  14. Rathbun DL, Shivdasani MN, Guo T, Fried S, Lovell NH, Hessburg P. The eye and the chip 2019-Conference Report. J Neural Eng. 2020 01 22; 17(1):010401. PMID: 31965978.
    Citations: 1     Fields:    Translation:Humans
  15. Raghuram V, Werginz P, Fried SI. Scaling of the AIS and Somatodendritic Compartments in a S RGCs. Front Cell Neurosci. 2019; 13:436. PMID: 31611777.
    Citations: 4     
  16. Ganji M, Paulk AC, Yang JC, Vahidi NW, Lee SH, Liu R, Hossain L, Arneodo EM, Thunemann M, Shigyo M, Tanaka A, Ryu SB, Lee SW, Tchoe Y, Marsala M, Devor A, Cleary DR, Martin JR, Oh H, Gilja V, Gentner TQ, Fried SI, Halgren E, Cash SS, Dayeh SA. Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces. . 2019 09 11; 19(9):6244-6254. PMID: 31369283.
    Citations: 3     Translation:AnimalsCells
  17. Werginz P, Fried SI. Comparison of electrically elicited responses in rabbit and mouse retinal ganglion cells. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:1813-1816. PMID: 31946249.
    Citations:    Translation:HumansAnimalsCells
  18. Guo T, Tsai D, Yang CY, Al Abed A, Twyford P, Fried SI, Morley JW, Suaning GJ, Dokos S, Lovell NH. Mediating Retinal Ganglion Cell Spike Rates Using High-Frequency Electrical Stimulation. Front Neurosci. 2019; 13:413. PMID: 31114476.
    Citations: 5     
  19. Ryu SB, Werginz P, Fried SI. Response of Mouse Visual Cortical Neurons to Electric Stimulation of the Retina. Front Neurosci. 2019; 13:324. PMID: 31019449.
    Citations: 1     
  20. Thyagarajan K, Fried SI. Micro-Coil Design Influences the Spatial Extent of Responses to Intracortical Magnetic Stimulation. IEEE Trans Biomed Eng. 2019 06; 66(6):1680-1694. PMID: 30369434.
    Citations: 3     Fields:    Translation:AnimalsCells
  21. Werginz P, Im M, Hadjinicolaou AE, Fried SI. Visual and electric spiking responses of seven types of rabbit retinal ganglion cells. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:2434-2437. PMID: 30440899.
    Citations: 2     Translation:AnimalsCells
  22. Ryu SB, Fried SI. Comparison of responses of visual cortical neurons in the mouse to intraocular and extraocular electric stimulation of the retina. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:2458-2461. PMID: 30440905.
    Citations:    Translation:AnimalsCells
  23. Zaeimbashi M, Wang Z, Lee SW, Cash S, Fried S, Sun N. Micro-solenoid inductors with magnetic core for neural stimulation. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:2230-2233. PMID: 30440849.
    Citations: 1     
  24. Im M, Werginz P, Fried SI. Electric stimulus duration alters network-mediated responses depending on retinal ganglion cell type. J Neural Eng. 2018 06; 15(3):036010. PMID: 29415876.
    Citations: 9     Fields:    Translation:AnimalsCells
  25. Freeman DK, O'Brien JM, Kumar P, Daniels B, Irion RA, Shraytah L, Ingersoll BK, Magyar AP, Czarnecki A, Wheeler J, Coppeta JR, Abban MP, Gatzke R, Fried SI, Lee SW, Duwel AE, Bernstein JJ, Widge AS, Hernandez-Reynoso A, Kanneganti A, Romero-Ortega MI, Cogan SF. A Sub-millimeter, Inductively Powered Neural Stimulator. Front Neurosci. 2017; 11:659. PMID: 29230164.
    Citations: 8     
  26. Fried SI. Network-mediated responses of ON ganglion cells to electric stimulation become less consistent across trials during retinal degeneration. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:2114-2117. PMID: 29060314.
    Citations: 1     Translation:AnimalsCells
  27. Lee SW, Fallegger F, Casse BD, Fried SI. Implantable microcoils for intracortical magnetic stimulation. Sci Adv. 2016 Dec; 2(12):e1600889. PMID: 27957537.
    Citations: 19     Fields:    Translation:AnimalsCells
  28. Lee SW, Fried SI. Enhanced Control of Cortical Pyramidal Neurons With Micromagnetic Stimulation. IEEE Trans Neural Syst Rehabil Eng. 2017 09; 25(9):1375-1386. PMID: 27893396.
    Citations: 9     Fields:    Translation:AnimalsCells
  29. Im M, Fried SI. Directionally selective retinal ganglion cells suppress luminance responses during natural viewing. Sci Rep. 2016 10 19; 6:35708. PMID: 27759086.
    Citations: 5     Fields:    Translation:AnimalsCells
  30. Im M, Fried SI. Temporal properties of network-mediated responses to repetitive stimuli are dependent upon retinal ganglion cell type. J Neural Eng. 2016 Apr; 13(2):025002. PMID: 26905231.
    Citations: 7     Fields:    Translation:AnimalsCells
  31. Im M, Fried SI. Indirect activation elicits strong correlations between light and electrical responses in ON but not OFF retinal ganglion cells. J Physiol. 2015 Aug 15; 593(16):3577-96. PMID: 26033477.
    Citations: 15     Fields:    Translation:AnimalsCells
  32. Twyford P, Fried S. The Retinal Response to Sinusoidal Electrical Stimulation. IEEE Trans Neural Syst Rehabil Eng. 2016 Apr; 24(4):413-23. PMID: 25850091.
    Citations: 7     Fields:    Translation:AnimalsCells
  33. Lee SW, Fried SI. Suppression of subthalamic nucleus activity by micromagnetic stimulation. IEEE Trans Neural Syst Rehabil Eng. 2015 Jan; 23(1):116-27. PMID: 25163063.
    Citations: 6     Fields:    Translation:AnimalsCells
  34. Twyford P, Cai C, Fried S. Differential responses to high-frequency electrical stimulation in ON and OFF retinal ganglion cells. J Neural Eng. 2014 Apr; 11(2):025001. PMID: 24556536.
    Citations: 23     Fields:    Translation:AnimalsCells
  35. Werginz P, Fried SI, Rattay F. Influence of the sodium channel band on retinal ganglion cell excitation during electric stimulation--a modeling study. Neuroscience. 2014 Apr 25; 266:162-77. PMID: 24560986.
    Citations: 9     Fields:    Translation:Cells
  36. Lee SW, Fried SI. The response of L5 pyramidal neurons of the PFC to magnetic stimulation from a micro-coil. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:6125-8. PMID: 25571395.
    Citations: 5     Translation:AnimalsCells
  37. Guo T, Lovell NH, Tsai D, Twyford P, Fried S, Morley JW, Suaning GJ, Dokos S. Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation: a computational modeling study. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:6108-11. PMID: 25571391.
    Citations: 4     Translation:HumansCells
  38. Cai C, Twyford P, Fried S. The response of retinal neurons to high-frequency stimulation. J Neural Eng. 2013 Jun; 10(3):036009. PMID: 23594620.
    Citations: 12     Fields:    Translation:AnimalsCells
  39. Fang Y, Cho KS, Tchedre K, Lee SW, Guo C, Kinouchi H, Fried S, Sun X, Chen DF. Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency. Stem Cells. 2013 Feb; 31(2):349-59. PMID: 23165658.
    Citations: 18     Fields:    Translation:AnimalsCells
  40. Lee SW, Eddington DK, Fried SI. Responses to pulsatile subretinal electric stimulation: effects of amplitude and duration. J Neurophysiol. 2013 Apr; 109(7):1954-68. PMID: 23343891.
    Citations: 16     Fields:    Translation:AnimalsCells
  41. Bonmassar G, Lee SW, Freeman DK, Polasek M, Fried SI, Gale JT. Microscopic magnetic stimulation of neural tissue. Nat Commun. 2012 Jun 26; 3:921. PMID: 22735449.
    Citations: 32     Fields:    Translation:HumansCells
  42. Freeman DK, Jeng JS, Kelly SK, Hartveit E, Fried SI. Calcium channel dynamics limit synaptic release in response to prosthetic stimulation with sinusoidal waveforms. J Neural Eng. 2011 Aug; 8(4):046005. PMID: 21628768.
    Citations: 12     Fields:    Translation:HumansCells
  43. Freeman DK, Rizzo JF, Fried SI. Encoding visual information in retinal ganglion cells with prosthetic stimulation. J Neural Eng. 2011 Jun; 8(3):035005. PMID: 21593546.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  44. Jeng J, Tang S, Molnar A, Desai NJ, Fried SI. The sodium channel band shapes the response to electric stimulation in retinal ganglion cells. J Neural Eng. 2011 Jun; 8(3):036022. PMID: 21558602.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  45. Cai C, Ren Q, Desai NJ, Rizzo JF, Fried SI. Response variability to high rates of electric stimulation in retinal ganglion cells. J Neurophysiol. 2011 Jul; 106(1):153-62. PMID: 21490287.
    Citations: 14     Fields:    Translation:AnimalsCells
  46. Freeman DK, Fried SI. Multiple components of ganglion cell desensitization in response to prosthetic stimulation. J Neural Eng. 2011 Feb; 8(1):016008. PMID: 21248379.
    Citations: 22     Fields:    Translation:AnimalsCells
  47. Fried SI, Cai C, Ren Q. High frequency electric stimulation of retinal neurons elicits physiological signaling patterns. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:1077-80. PMID: 22254500.
    Citations: 1     Translation:AnimalsCells
  48. Freeman DK, Eddington DK, Rizzo JF, Fried SI. Selective activation of neuronal targets with sinusoidal electric stimulation. J Neurophysiol. 2010 Nov; 104(5):2778-91. PMID: 20810683.
    Citations: 44     Fields:    Translation:AnimalsCells
  49. Freeman DK, Rizzo JF, Fried SI. Electric stimulation with sinusoids and white noise for neural prostheses. Front Neurosci. 2010; 4:28. PMID: 20582268.
    Citations: 5     
  50. Fried SI, Lasker AC, Desai NJ, Eddington DK, Rizzo JF. Axonal sodium-channel bands shape the response to electric stimulation in retinal ganglion cells. J Neurophysiol. 2009 Apr; 101(4):1972-87. PMID: 19193771.
    Citations: 83     Fields:    Translation:AnimalsCells
  51. Fried SI, Masland RH. Image processing: how the retina detects the direction of image motion. Curr Biol. 2007 Jan 23; 17(2):R63-6. PMID: 17240332.
    Citations: 9     Fields:    Translation:AnimalsCells
  52. Fried SI, Hsueh HA, Werblin FS. A method for generating precise temporal patterns of retinal spiking using prosthetic stimulation. J Neurophysiol. 2006 Feb; 95(2):970-8. PMID: 16236780.
    Citations: 74     Fields:    Translation:AnimalsCells
  53. Fried SI, Münch TA, Werblin FS. Directional selectivity is formed at multiple levels by laterally offset inhibition in the rabbit retina. Neuron. 2005 Apr 07; 46(1):117-27. PMID: 15820698.
    Citations: 51     Fields:    Translation:AnimalsCells
  54. Fried SI, Münch TA, Werblin FS. Mechanisms and circuitry underlying directional selectivity in the retina. Nature. 2002 Nov 28; 420(6914):411-4. PMID: 12459782.
    Citations: 127     Fields:    Translation:AnimalsCells
  55. Gaumond RP, Fried SI. Analysis of cat multichannel acoustic brain-stem response data using dipole localization methods. Electroencephalogr Clin Neurophysiol. 1986 Apr; 63(4):376-83. PMID: 2419096.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.