Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Bruce David Walker, M.D.

Co-Author

This page shows the publications co-authored by Bruce Walker and Todd Allen.
Connection Strength

5.384
  1. Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J Virol. 2005 Nov; 79(21):13239-49.
    View in: PubMed
    Score: 0.330
  2. Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection. J Virol. 2004 Jul; 78(13):7069-78.
    View in: PubMed
    Score: 0.301
  3. STI and beyond: the prospects of boosting anti-HIV immune responses. Trends Immunol. 2002 Sep; 23(9):456-60.
    View in: PubMed
    Score: 0.265
  4. Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia. Immunity. 2021 Oct 12; 54(10):2372-2384.e7.
    View in: PubMed
    Score: 0.248
  5. Structural topology defines protective CD8+ T cell epitopes in the HIV proteome. Science. 2019 05 03; 364(6439):480-484.
    View in: PubMed
    Score: 0.211
  6. Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Immunity. 2016 10 18; 45(4):917-930.
    View in: PubMed
    Score: 0.177
  7. Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus. PLoS Pathog. 2016 05; 12(5):e1005619.
    View in: PubMed
    Score: 0.171
  8. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nat Immunol. 2012 Jun 10; 13(7):691-700.
    View in: PubMed
    Score: 0.131
  9. Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection. PLoS Pathog. 2012; 8(3):e1002529.
    View in: PubMed
    Score: 0.128
  10. Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection. J Virol. 2010 Nov; 84(22):11937-49.
    View in: PubMed
    Score: 0.115
  11. Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes. J Virol. 2009 Apr; 83(7):3138-49.
    View in: PubMed
    Score: 0.103
  12. Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome. AIDS. 2009 Jan 14; 23(2):259-62.
    View in: PubMed
    Score: 0.103
  13. HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition. J Virol. 2009 Mar; 83(6):2743-55.
    View in: PubMed
    Score: 0.103
  14. Transmission and long-term stability of compensated CD8 escape mutations. J Virol. 2009 Apr; 83(8):3993-7.
    View in: PubMed
    Score: 0.103
  15. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients. Hepatology. 2008 Dec; 48(6):1769-78.
    View in: PubMed
    Score: 0.102
  16. Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1. J Virol. 2009 Feb; 83(4):1845-55.
    View in: PubMed
    Score: 0.102
  17. HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1. J Virol. 2009 Jan; 83(1):140-9.
    View in: PubMed
    Score: 0.102
  18. Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection. J Virol. 2008 Sep; 82(18):9216-27.
    View in: PubMed
    Score: 0.099
  19. Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes. J Virol. 2008 Sep; 82(17):8422-30.
    View in: PubMed
    Score: 0.099
  20. Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. J Virol. 2008 Jun; 82(11):5594-605.
    View in: PubMed
    Score: 0.098
  21. Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A. J Virol. 2007 Nov; 81(22):12608-18.
    View in: PubMed
    Score: 0.094
  22. Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection. Blood. 2007 Sep 01; 110(5):1559-69.
    View in: PubMed
    Score: 0.092
  23. Characterization of full-length hepatitis C virus genotype 4 sequences. J Viral Hepat. 2007 May; 14(5):330-7.
    View in: PubMed
    Score: 0.092
  24. Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection. PLoS Med. 2006 Dec; 3(12):e492.
    View in: PubMed
    Score: 0.089
  25. Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes. J Virol. 2007 Feb; 81(4):1619-31.
    View in: PubMed
    Score: 0.089
  26. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1. PLoS Med. 2006 Oct; 3(10):e403.
    View in: PubMed
    Score: 0.088
  27. De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection. J Virol. 2005 Oct; 79(20):12952-60.
    View in: PubMed
    Score: 0.082
  28. Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy. J Virol. 2005 Oct; 79(20):12979-88.
    View in: PubMed
    Score: 0.082
  29. Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry. J Virol Methods. 2006 Feb; 131(2):134-42.
    View in: PubMed
    Score: 0.082
  30. Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. J Immunol. 2005 Sep 15; 175(6):3603-13.
    View in: PubMed
    Score: 0.082
  31. Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection. J Virol. 2005 Jul; 79(13):8171-81.
    View in: PubMed
    Score: 0.081
  32. The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design. J Virol. 2005 Apr; 79(8):5000-5.
    View in: PubMed
    Score: 0.079
  33. CD8 epitope escape and reversion in acute HCV infection. J Exp Med. 2004 Dec 20; 200(12):1593-604.
    View in: PubMed
    Score: 0.078
  34. Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection. J Virol. 2004 Jan; 78(2):630-41.
    View in: PubMed
    Score: 0.073
  35. Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection. AIDS. 2003 Dec 05; 17(18):2581-91.
    View in: PubMed
    Score: 0.072
  36. Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences. J Virol. 2003 Jul; 77(13):7330-40.
    View in: PubMed
    Score: 0.070
  37. HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus. Nature. 2002 Nov 28; 420(6914):434-9.
    View in: PubMed
    Score: 0.067
  38. Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells. Biomaterials. 2017 02; 117:44-53.
    View in: PubMed
    Score: 0.044
  39. Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection. Retrovirology. 2013 Nov 18; 10:139.
    View in: PubMed
    Score: 0.036
  40. Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. J Immunol. 2013 Jul 15; 191(2):540-4.
    View in: PubMed
    Score: 0.035
  41. Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection. J Virol. 2012 Jun; 86(12):6986-93.
    View in: PubMed
    Score: 0.032
  42. Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection. AIDS. 2012 Mar 13; 26(5):533-41.
    View in: PubMed
    Score: 0.032
  43. Definition of the viral targets of protective HIV-1-specific T cell responses. J Transl Med. 2011 Dec 07; 9:208.
    View in: PubMed
    Score: 0.032
  44. A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais. PLoS One. 2011; 6(8):e23603.
    View in: PubMed
    Score: 0.031
  45. Coordinate linkage of HIV evolution reveals regions of immunological vulnerability. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11530-5.
    View in: PubMed
    Score: 0.031
  46. Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers. J Acquir Immune Defic Syndr. 2011 Feb 01; 56(2):100-8.
    View in: PubMed
    Score: 0.030
  47. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science. 2010 Dec 10; 330(6010):1551-7.
    View in: PubMed
    Score: 0.029
  48. Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes. Gastroenterology. 2011 Feb; 140(2):686-696.e1.
    View in: PubMed
    Score: 0.029
  49. Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature. 2010 May 20; 465(7296):350-4.
    View in: PubMed
    Score: 0.028
  50. Adaptation of HIV-1 to human leukocyte antigen class I. Nature. 2009 Apr 02; 458(7238):641-5.
    View in: PubMed
    Score: 0.026
  51. HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering. J Virol. 2009 May; 83(9):4605-15.
    View in: PubMed
    Score: 0.026
  52. Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS Med. 2008 May 06; 5(5):e100.
    View in: PubMed
    Score: 0.025
  53. Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity. AIDS. 2008 Feb 19; 22(4):447-56.
    View in: PubMed
    Score: 0.024
  54. High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol. 2008 Mar; 82(6):3154-60.
    View in: PubMed
    Score: 0.024
  55. A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells. J Exp Med. 2007 Nov 26; 204(12):2813-24.
    View in: PubMed
    Score: 0.024
  56. Increased sequence diversity coverage improves detection of HIV-specific T cell responses. J Immunol. 2007 Nov 15; 179(10):6638-50.
    View in: PubMed
    Score: 0.024
  57. Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression. AIDS. 2007 Apr 23; 21(7):889-91.
    View in: PubMed
    Score: 0.023
  58. Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection. J Virol. 2007 Apr; 81(8):4199-214.
    View in: PubMed
    Score: 0.023
  59. Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection. J Infect Dis. 2006 Sep 15; 194(6):734-9.
    View in: PubMed
    Score: 0.022
  60. Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus. J Exp Med. 2006 Mar 20; 203(3):529-39.
    View in: PubMed
    Score: 0.021
  61. Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control. J Virol. 2006 Mar; 80(6):3122-5.
    View in: PubMed
    Score: 0.021
  62. Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes. Nat Immunol. 2006 Feb; 7(2):173-8.
    View in: PubMed
    Score: 0.021
  63. Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire. Blood. 2006 Mar 15; 107(6):2373-83.
    View in: PubMed
    Score: 0.021
  64. HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load. J Virol. 2005 Aug; 79(16):10218-25.
    View in: PubMed
    Score: 0.020
  65. HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response. J Immunol. 2005 Jun 15; 174(12):7524-30.
    View in: PubMed
    Score: 0.020
  66. Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature. 2004 Dec 09; 432(7018):769-75.
    View in: PubMed
    Score: 0.019
  67. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology. 2004 Sep; 127(3):924-36.
    View in: PubMed
    Score: 0.019
  68. HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity. AIDS. 2004 Jul 02; 18(10):1383-92.
    View in: PubMed
    Score: 0.019
  69. Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians. AIDS Res Hum Retroviruses. 2004 May; 20(5):557-64.
    View in: PubMed
    Score: 0.019
  70. HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha. Blood. 2004 Jul 15; 104(2):487-94.
    View in: PubMed
    Score: 0.018
  71. HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication. Lancet. 2004 Mar 13; 363(9412):863-6.
    View in: PubMed
    Score: 0.018
  72. Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells. AIDS Res Hum Retroviruses. 2004 Mar; 20(3):315-25.
    View in: PubMed
    Score: 0.018
  73. HIV evolution: CTL escape mutation and reversion after transmission. Nat Med. 2004 Mar; 10(3):282-9.
    View in: PubMed
    Score: 0.018
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.