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Michael William Donnino, M.D.

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Overview
Dr. Michael Donnino is an attending physician in the Department of Emergency Medicine and Division of Pulmonary/Critical Care Medicine at Beth Israel Deaconess Medical Center. His clinical practice spans both the intensive care unit as well as the emergency department. Dr. Donnino was the first person in the country to train in a 6-year combined emergency medicine, internal medicine, and critical care program leading to board certification in all three areas. Dr. Donnino is also the Director of the Center for Resuscitation Science and Director of Critical Care in Emergency Medicine. Dr. Donnino’s research interests include clinical trials and clinical investigations in septic shock and cardiac arrest. In the field of cardiac arrest, Dr. Donnino is the lead investigator of a multi-center clinical trial evaluating the use of steroids in post-arrest shock and a multi-center trial evaluating thiamine as a metabolic resuscitator in septic shock. Other notable studies include an investigation in microcirculatory dysfunction post-arrest, an evaluation of the human metabolome in sepsis and post-cardiac arrest, and severity of illness scoring systems in post-cardiac arrest patients. Dr. Donnino is a member of the Advanced Cardiac Life Support (ACLS) Subcommittee at the American Heart Association and co-author of sections of the 2010 ACLS guidelines.

Mentoring
Thiamine Deficiency in Critically Ill Patients with Sepsis
Summer, 06/18/07 - 08/10/07

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK130929 (DONNINO, MICHAEL WILLIAM) Dec 15, 2021 - Nov 30, 2026
    NIH
    Corticosteroids to Reduce Inflammation in Severe Pancreatitis (CRISP)
    Role: Principal Investigator
  2. T32HL155020 (DONNINO, MICHAEL WILLIAM) Dec 1, 2020 - Jan 31, 2026
    NIH
    Training Program in Resuscitation Science
    Role: Principal Investigator
  3. R01DK112886 (DONNINO, MICHAEL WILLIAM) Sep 1, 2018 - Jun 30, 2023
    NIH
    Thiamine as Adjunctive Therapy for Diabetic Ketoacidosis
    Role: Principal Investigator
  4. R03AA026093 (DONNINO, MICHAEL WILLIAM) Sep 1, 2018 - Aug 31, 2021
    NIH
    Thiamine in septic shock patients with alcohol abuse
    Role: Principal Investigator
  5. R01HL136705 (DONNINO, MICHAEL WILLIAM) Apr 1, 2017 - Mar 31, 2022
    NIH
    Thiamine As A Metabolic Resuscitator In Cardiac Arrest
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 276 total Publications Show all
  1. La Camera D, Elmer J, Perman SM, Donnino MW, Wu O, Parker RA, Vranceanu AM, Presciutti AM. A mind-body resilience intervention for emotional distress in cardiac arrest survivors and their informal caregivers - Recovering together after cardiac arrest: Protocol for an open pilot trial. Contemp Clin Trials Commun. 2025 Feb; 43:101426. PMID: 39866903; PMCID: PMC11757219.
    Citations:
  2. Vine J, Lee JH, Moskowitz A, Donnino MW. Thiamine administration in septic shock: towards finding the target population. Crit Care. 2024 Dec 18; 28(1):422. PMID: 39695817; PMCID: PMC11656968.
    Citations:
    Fields: CriCritical Care
  3. Ross CE, Sorcher JL, Gardner R, Pannu A, Kleinman ME, Donnino MW, Sullivan AM, Hayes MM. Why physicians use sodium bicarbonate during cardiac arrest: A cross-sectional survey study of adult and pediatric clinicians. Resusc Plus. 2024 Dec; 20:100830. PMID: 39649705; PMCID: PMC11625150.
    Citations:
  4. Vine J, Moskowitz A, Donnino MW. The uncertainty principle: a novel approach to optimizing trials in critical care. Curr Opin Crit Care. 2024 Dec 01; 30(6):583-586. PMID: 39503209.
    Citations:
    Fields: CriCritical Care
  5. Vine J, Lee JH, Balaji L, Grossestreuer AV, Morton A, Peradze N, Antony N, Berlin N, Kravitz MS, Leland SB, Berg K, Moskowitz A, Donnino MW, Liu X. Cellular oxygen consumption in patients with diabetic ketoacidosis. Intensive Care Med Exp. 2024 Nov 04; 12(1):97. PMID: 39497011; PMCID: PMC11535118.
    Citations:
  6. Presciutti AM, Siry-Bove B, Parker RA, Wu O, Elmer J, Donnino MW, Perman SM, Vranceanu AM. Thematic analysis of cardiac arrest survivors' and their caregivers' psychosocial intervention needs. Gen Hosp Psychiatry. 2025 Jan-Feb; 92:125-127. PMID: 39462752.
    Citations:
    Fields: HosHospitalsPsyPsychiatry
  7. Presciutti AM, Elmer J, Donnino MW, Wu O, Parker RA, Perman SM, Vranceanu AM. Preventing chronic distress in cardiac arrest survivors and their caregivers: Perspectives of multidisciplinary healthcare professionals. Gen Hosp Psychiatry. 2024 Nov-Dec; 91:259-262. PMID: 39341731.
    Citations:
    Fields: HosHospitalsPsyPsychiatry
  8. Paschali M, Thompson GS, Mehta S, Howard PM, Yamin JB, Edwards RR, Donnino MW. Psychophysiologic symptom relief therapy for chronic back pain: hypothesis and trial rationale. Front Pain Res (Lausanne). 2024; 5:1328495. PMID: 39091382; PMCID: PMC11291320.
    Citations:
  9. Shea MG, Balaji L, Grossestreuer AV, Issa MS, Silverman J, Li F, Donnino MW, Berg KM. Oxygen metabolism after cardiac arrest: Patterns and associations with survival. Resusc Plus. 2024 Sep; 19:100667. PMID: 38827271; PMCID: PMC11143887.
    Citations:
  10. Moskowitz A, Donnino MW. Reply to Mumin et al.: The Challenges of Using and Measuring Thiamine in Critical Care. Am J Respir Crit Care Med. 2024 03 01; 209(5):607-608. PMID: 37972374; PMCID: PMC10919115.
    Citations: 1
    Fields: CriCritical CarePulPulmonary MedicineTranslation:Humans
  11. Vine J, Mehta S, Balaji L, Berg KM, Berlin N, Liu X, Ngo L, Shea M, Moskowitz A, Donnino MW, Grossestreuer AV. Thiamine as adjunctive therapy for diabetic ketoacidosis (DKAT) trial protocol and statistical analysis plan: a prospective, single-centre, double-blind, randomised, placebo-controlled clinical trial in the USA. BMJ Open. 2024 02 29; 14(2):e077586. PMID: 38423765; PMCID: PMC10910407.
    Citations:
    Fields: MedMedicine (General)Translation:HumansCTClinical Trials
  12. Vine J, Berlin N, Moskowitz A, Berg KM, Liu X, Balaji L, Donnino MW, Grossestreuer AV. Corticosteroids to Reduce Inflammation in Severe Pancreatitis (CRISP) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomized, placebo controlled clinical trial. Contemp Clin Trials. 2024 04; 139:107486. PMID: 38431131; PMCID: PMC11131038.
    Citations:
    Fields: MedMedicine (General)TheTherapeuticsTranslation:HumansCellsCTClinical Trials
  13. Donnino MW, Berg KM, Vine J, Balaji L, Berlin N, Cocchi MN, Moskowitz A, Chase M, Li F, Mehta S, Silverman J, Heydrick S, Liu X, Grossestreuer AV, BIDMC Center for Resuscitation Science at the time of their contributions. Thiamine as a metabolic resuscitator after out-of-hospital cardiac arrest. Resuscitation. 2024 05; 198:110158. PMID: 38428720.
    Citations: 2
    Fields: EmeEmergency MedicineTranslation:HumansCTClinical Trials
  14. Berg KM, Grossestreuer AV, Balaji L, Moskowitz A, Berlin N, Cocchi MN, Morton AC, Li F, Mehta S, Peradze N, Silverman J, Liu X, Donnino MW. Thiamine as a metabolic resuscitator after in-hospital cardiac arrest. Resuscitation. 2024 05; 198:110160. PMID: 38428722.
    Citations: 1
    Fields: EmeEmergency MedicineTranslation:HumansCTClinical Trials
  15. Vine J, Lee JH, Kravitz MS, Grossestreuer AV, Balaji L, Leland SB, Berlin N, Moskowitz A, Donnino MW. Thiamine administration in septic shock: a post hoc analysis of two randomized trials. Crit Care. 2024 02 06; 28(1):41. PMID: 38321529; PMCID: PMC10845751.
    Citations: 4
    Fields: CriCritical CareTranslation:HumansCTClinical Trials
  16. Coppler PJ, Gagnon DJ, Flickinger KL, Elmer J, Callaway CW, Guyette FX, Doshi A, Steinberg A, Dezfulian C, Moskowitz AL, Donnino M, May TL, Seder DB, Rittenberger JC. A multicenter, randomized, doubleblind, placebo-controlled trial of amantadine to stimulate awakening in comatose patients resuscitated from cardiac arrest. Clin Exp Emerg Med. 2024 Jun; 11(2):205-212. PMID: 38286499; PMCID: PMC11237252.
    Citations:
  17. Moskowitz A, Andrea L, Shiloh AL, Cardasis J, Carty C, Kim M, Xie X, McAllen S, Esses D, Lutz C, Takematsu M, Romero J, Schimmrich K, Fein DG, Dodi AE, Rednor S, Bangar M, Mohamed A, Eisen LA, Wang HE, Donnino MW, Gong MN. Design and implementation of the hospital airway resuscitation trial. Resusc Plus. 2024 Mar; 17:100512. PMID: 38076388; PMCID: PMC10698666.
    Citations:
  18. Berlin N, Pfaff A, Rozanski EA, Chalifoux NV, Hess RS, Donnino MW, Silverstein DC. Establishment of a reference interval for thiamine concentrations in healthy dogs and evaluation of the prevalence of absolute thiamine deficiency in critically ill dogs with and without sepsis using high-performance liquid chromatography. J Vet Emerg Crit Care (San Antonio). 2024 Jan-Feb; 34(1):49-56. PMID: 37987121; PMCID: PMC11007751.
    Citations:
    Fields: CriCritical CareEmeEmergency MedicineVetVeterinary MedicineTranslation:HumansAnimals
  19. Pester BD, Yamin JB, Cabrera MJ, Mehta S, Silverman J, Grossestreuer AV, Howard P, Edwards RR, Donnino MW. Change in Pain-Related Anxiety Mediates the Effects of Psychophysiologic Symptom Relief Therapy (PSRT) on Pain Disability for Chronic Back Pain: Secondary Results from a Randomized Controlled Trial. J Pain Res. 2023; 16:3871-3880. PMID: 38026456; PMCID: PMC10655606.
    Citations: 1
  20. Hoeyer-Nielsen AK, Holmberg MJ, Grossestreuer AV, Yankama T, Berg KM, Donnino MW. OXYGEN CONSUMPTION AS AN EARLY WARNING SYSTEM IN THE CRITICALLY ILL. Shock. 2023 10 01; 60(4):539-544. PMID: 37752082.
    Citations:
    Fields: CarCardiologyVasVascular DiseasesTranslation:Humans
  21. Ross CE, Asad M, Kleinman ME, Donnino MW. Can an individual be enrolled in more than one clinical trial using exception from informed consent? Acad Emerg Med. 2024 03; 31(3):301-304. PMID: 37634126; PMCID: PMC10897057.
    Citations:
    Fields: EmeEmergency MedicineTranslation:Humans
  22. Moskowitz A, Berg KM, Grossestreuer AV, Balaji L, Liu X, Cocchi MN, Chase M, Gong MN, Gong J, Parikh SM, Ngo L, Berlin N, Donnino MW. Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-controlled, Clinical Trial. Am J Respir Crit Care Med. 2023 09 01; 208(5):570-578. PMID: 37364280; PMCID: PMC10492240.
    Citations: 8
    Fields: CriCritical CarePulPulmonary MedicineTranslation:Humans
  23. Perman SM, Bartos JA, Del Rios M, Donnino MW, Hirsch KG, Jentzer JC, Kudenchuk PJ, Kurz MC, Maciel CB, Menon V, Panchal AR, Rittenberger JC, Berg KM, American Heart Association Emergency Cardiovascular Care Committee, Council on Cardiovascular Surger. Temperature Management for Comatose Adult Survivors of Cardiac Arrest: A Science Advisory From the American Heart Association. Circulation. 2023 09 19; 148(12):982-988. PMID: 37584195.
    Citations: 7
    Fields: CarCardiologyVasVascular DiseasesTranslation:Humans
  24. Berlin N, Pawar RD, Liu X, Balaji L, Morton AC, Silverman J, Li F, Issa MS, Roessler LL, Holmberg MJ, Shekhar AC, Donnino MW, Moskowitz A, Grossestreuer AV. Kidney-specific biomarkers for predicting acute kidney injury following cardiac arrest. Resuscitation. 2023 09; 190:109911. PMID: 37499974; PMCID: PMC10529996.
    Citations:
    Fields: EmeEmergency MedicineTranslation:Humans
  25. Donnino M, Howard P, Mehta S, Silverman J, Cabrera MJ, Yamin JB, Balaji L, Berg KM, Heydrick S, Edwards R, Grossestreuer AV. Psychophysiologic Symptom Relief Therapy (PSRT) for Post-acute Sequelae of COVID-19. Mayo Clin Proc Innov Qual Outcomes. 2023 May 19. PMID: 37361483; PMCID: PMC10196153.
    Citations: 1
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.