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Eugene Park Rhee, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NR017399 (RHEE, EUGENE P) Aug 22, 2018 - May 31, 2023
    NIH/NINR
    Metabolomics of Uremic Symptoms in Dialysis Patients
    Role: Principal Investigator
  2. U01DK106981 (RHEE, EUGENE P) Sep 14, 2015 - Jul 31, 2020
    NIH/NIDDK
    Metabolomics of CKD and CKD Progression
    Role: Principal Investigator
  3. K08DK090142 (RHEE, EUGENE P) Sep 1, 2011 - May 31, 2016
    NIH/NIDDK
    Metabolite Profiling and Cardiovascular Mortality in End-stage Renal Disease
    Role: Principal Investigator
  4. F32DK085860 (RHEE, EUGENE P) Jan 1, 2011 - Jun 30, 2011
    NIH/NIDDK
    Metabolomic Biomarkers of CKD
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS. Author Correction: Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Nature. 2019 Jun; 570(7759):E23. PMID: 31089212.
    Citations:    
  2. Hu JR, Grams ME, Coresh J, Hwang S, Kovesdy CP, Guallar E, Rhee EP, Shafi T. Serum Metabolites and Cardiac Death in Patients on Hemodialysis. Clin J Am Soc Nephrol. 2019 May 07; 14(5):747-749. PMID: 30962187.
    Citations:    
  3. Titan SM, Venturini G, Padilha K, Goulart AC, Lotufo PA, Bensenor IJ, Krieger JE, Thadhani RI, Rhee EP, Pereira AC. Metabolomics biomarkers and the risk of overall mortality and ESRD in CKD: Results from the Progredir Cohort. PLoS One. 2019; 14(3):e0213764. PMID: 30883578.
    Citations:    
  4. Kim W, Deik A, Gonzalez C, Gonzalez ME, Fu F, Ferrari M, Churchhouse CL, Florez JC, Jacobs SBR, Clish CB, Rhee EP. Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+ Recycling. Cell Metab. 2019 Apr 02; 29(4):856-870.e7. PMID: 30686744.
    Citations:    Fields:    
  5. Rhee EP, Waikar SS, Rebholz CM, Zheng Z, Perichon R, Clish CB, Evans AM, Avila J, Denburg MR, Anderson AH, Vasan RS, Feldman HI, Kimmel PL, Coresh J. Variability of Two Metabolomic Platforms in CKD. Clin J Am Soc Nephrol. 2019 Jan 07; 14(1):40-48. PMID: 30573658.
    Citations:    Fields:    
  6. Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS. Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Nature. 2019 01; 565(7737):96-100. PMID: 30487609.
    Citations:    Fields:    
  7. Titan SM, Venturini G, Padilha K, Tavares G, Zatz R, Bensenor I, Lotufo PA, Rhee EP, Thadhani RI, Pereira AC. Metabolites related to eGFR: Evaluation of candidate molecules for GFR estimation using untargeted metabolomics. Clin Chim Acta. 2019 Feb; 489:242-248. PMID: 30153452.
    Citations:    Fields:    
  8. Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM. De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Nat Med. 2018 09; 24(9):1351-1359. PMID: 30127395.
    Citations:    Fields:    
  9. Afshinnia F, Zeng L, Byun J, Wernisch S, Deo R, Chen J, Hamm L, Miller ER, Rhee EP, Fischer MJ, Sharma K, Feldman HI, Michailidis G, Pennathur S. Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease. Nephrol Dial Transplant. 2018 Jul 25. PMID: 30137494.
    Citations:    Fields:    
  10. Grams ME, Shafi T, Rhee EP. Metabolomics Research in Chronic Kidney Disease. J Am Soc Nephrol. 2018 Jun; 29(6):1588-1590. PMID: 29724883.
    Citations:    Fields:    
  11. Rhee EP. A Systems-Level View of Renal Metabolomics. Semin Nephrol. 2018 03; 38(2):142-150. PMID: 29602397.
    Citations:    Fields:    Translation:HumansAnimals
  12. Elmariah S, Farrell LA, Furman D, Lindman BR, Shi X, Morningstar JE, Rhee EP, Gerszten RE. Association of Acylcarnitines With Left Ventricular Remodeling in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. JAMA Cardiol. 2018 Mar 01; 3(3):242-246. PMID: 29299604.
    Citations:    Fields:    
  13. Tavares G, Venturini G, Padilha K, Zatz R, Pereira AC, Thadhani RI, Rhee EP, Titan SMO. 1,5-Anhydroglucitol predicts CKD progression in macroalbuminuric diabetic kidney disease: results from non-targeted metabolomics. Metabolomics. 2018 02 27; 14(4):39. PMID: 30830377.
    Citations:    
  14. Rhee EP. How Omics Data Can Be Used in Nephrology. Am J Kidney Dis. 2018 Jul; 72(1):129-135. PMID: 29478865.
    Citations:    Fields:    
  15. Christov M, Clark AR, Corbin B, Hakroush S, Rhee EP, Saito H, Brooks D, Hesse E, Bouxsein M, Galjart N, Jung JY, Mundel P, Jüppner H, Weins A, Greka A. Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. JCI Insight. 2018 Feb 22; 3(4). PMID: 29467330.
    Citations: 1     Fields:    
  16. Kalim S, Wald R, Yan AT, Goldstein MB, Kiaii M, Xu D, Berg AH, Clish C, Thadhani R, Rhee EP, Perl J. Extended Duration Nocturnal Hemodialysis and Changes in Plasma Metabolite Profiles. Clin J Am Soc Nephrol. 2018 Mar 07; 13(3):436-444. PMID: 29444900.
    Citations: 4     Fields:    
  17. Miller A, Rhee E, Gettman M, Spitz A. The Current State of Telemedicine in Urology. Med Clin North Am. 2018 Mar; 102(2):387-398. PMID: 29406066.
    Citations:    Fields:    Translation:Humans
  18. Kalim S, Rhee EP. Metabolomics and Kidney Precision Medicine. Clin J Am Soc Nephrol. 2017 11 07; 12(11):1726-1727. PMID: 28971981.
    Citations:    Fields:    Translation:Humans
  19. Friesen M, Camahort R, Lee YK, Xia F, Gerszten RE, Rhee EP, Deo RC, Cowan CA. Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease. Stem Cell Reports. 2017 05 09; 8(5):1164-1173. PMID: 28416283.
    Citations:    Fields:    Translation:HumansAnimalsCells
  20. Cheng S, Shah SH, Corwin EJ, Fiehn O, Fitzgerald RL, Gerszten RE, Illig T, Rhee EP, Srinivas PR, Wang TJ, Jain M. Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2017 Apr; 10(2). PMID: 28360086.
    Citations: 6     Fields:    Translation:Humans
  21. McMahon GM, Hwang SJ, Clish CB, Tin A, Yang Q, Larson MG, Rhee EP, Li M, Levy D, O'Donnell CJ, Coresh J, Young JH, Gerszten RE, Fox CS. Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease. Kidney Int. 2017 06; 91(6):1426-1435. PMID: 28302371.
    Citations: 4     Fields:    Translation:Humans
  22. Kalim S, Rhee EP. An overview of renal metabolomics. Kidney Int. 2017 01; 91(1):61-69. PMID: 27692817.
    Citations: 8     Fields:    Translation:HumansCells
  23. Afshinnia F, Rajendiran TM, Karnovsky A, Soni T, Wang X, Xie D, Yang W, Shafi T, Weir MR, He J, Brecklin CS, Rhee EP, Schelling JR, Ojo A, Feldman H, Michailidis G, Pennathur S. Lipidomic Signature of Progression of Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort. Kidney Int Rep. 2016 Nov; 1(4):256-268. PMID: 28451650.
    Citations: 2     
  24. Rhee EP, Yang Q, Yu B, Liu X, Cheng S, Deik A, Pierce KA, Bullock K, Ho JE, Levy D, Florez JC, Kathiresan S, Larson MG, Vasan RS, Clish CB, Wang TJ, Boerwinkle E, O'Donnell CJ, Gerszten RE. An exome array study of the plasma metabolome. Nat Commun. 2016 07 25; 7:12360. PMID: 27453504.
    Citations: 8     Fields:    Translation:Humans
  25. Rhee EP, Clish CB, Wenger J, Roy J, Elmariah S, Pierce KA, Bullock K, Anderson AH, Gerszten RE, Feldman HI. Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study. Am J Nephrol. 2016; 43(5):366-74. PMID: 27172772.
    Citations: 5     Fields:    Translation:Humans
  26. Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM. PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature. 2016 Mar 24; 531(7595):528-32. PMID: 26982719.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  27. Elmariah S, Farrell LA, Daher M, Shi X, Keyes MJ, Cain CH, Pomerantsev E, Vlahakes GJ, Inglessis I, Passeri JJ, Palacios IF, Fox CS, Rhee EP, Gerszten RE. Metabolite Profiles Predict Acute Kidney Injury and Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement. J Am Heart Assoc. 2016 Mar 15; 5(3):e002712. PMID: 27068627.
    Citations: 3     Fields:    Translation:Humans
  28. Ho JE, Larson MG, Ghorbani A, Cheng S, Chen MH, Keyes M, Rhee EP, Clish CB, Vasan RS, Gerszten RE, Wang TJ. Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes. PLoS One. 2016; 11(2):e0148361. PMID: 26863521.
    Citations: 19     Fields:    Translation:Humans
  29. Henry GD, Karpman E, Brant W, Christine B, Kansas BT, Khera M, Jones L, Kohler T, Bennett N, Rhee E, Eisenhart E, Bella AJ. The Who, How and What of Real-World Penile Implantation in 2015: The PROPPER Registry Baseline Data. J Urol. 2016 Feb; 195(2):427-33. PMID: 26292043.
    Citations: 7     Fields:    Translation:Humans
  30. Rhee EP. NADPH Oxidase 4 at the Nexus of Diabetes, Reactive Oxygen Species, and Renal Metabolism. J Am Soc Nephrol. 2016 Feb; 27(2):337-9. PMID: 26203117.
    Citations: 1     Fields:    Translation:Animals
  31. Kalim S, Clish CB, Deferio JJ, Ortiz G, Moffet AS, Gerszten RE, Thadhani R, Rhee EP. Cross-sectional examination of metabolites and metabolic phenotypes in uremia. BMC Nephrol. 2015 Jul 07; 16:98. PMID: 26149577.
    Citations: 2     Fields:    Translation:Humans
  32. Rhee EP. Metabolomics and renal disease. Curr Opin Nephrol Hypertens. 2015 Jul; 24(4):371-9. PMID: 26050125.
    Citations: 5     Fields:    Translation:Humans
  33. van Ballegooijen AJ, Rhee EP, Elmariah S, de Boer IH, Kestenbaum B. Renal Clearance of Mineral Metabolism Biomarkers. J Am Soc Nephrol. 2016 Feb; 27(2):392-7. PMID: 26047790.
    Citations: 5     Fields:    Translation:Humans
  34. Cheng S, Larson MG, McCabe EL, Murabito JM, Rhee EP, Ho JE, Jacques PF, Ghorbani A, Magnusson M, Souza AL, Deik AA, Pierce KA, Bullock K, O'Donnell CJ, Melander O, Clish CB, Vasan RS, Gerszten RE, Wang TJ. Distinct metabolomic signatures are associated with longevity in humans. Nat Commun. 2015 Apr 13; 6:6791. PMID: 25864806.
    Citations: 12     Fields:    Translation:Humans
  35. Rhee EP, Clish CB, Pierce KA, Saad A, Lerman LO, Textor SC. Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension. J Hypertens. 2015 Apr; 33(4):836-42. PMID: 25490710.
    Citations: 4     Fields:    Translation:Humans
  36. Rhee EP, Feldman HI. Metabolite markers of incident CKD risk. Clin J Am Soc Nephrol. 2014 Aug 07; 9(8):1344-6. PMID: 25011443.
    Citations: 2     Fields:    Translation:Humans
  37. Walford GA, Porneala BC, Dauriz M, Vassy JL, Cheng S, Rhee EP, Wang TJ, Meigs JB, Gerszten RE, Florez JC. Metabolite traits and genetic risk provide complementary information for the prediction of future type 2 diabetes. Diabetes Care. 2014 Sep; 37(9):2508-14. PMID: 24947790.
    Citations: 18     Fields:    Translation:Humans
  38. Pendergraft WF, Cortazar FB, Wenger J, Murphy AP, Rhee EP, Laliberte KA, Niles JL. Long-term maintenance therapy using rituximab-induced continuous B-cell depletion in patients with ANCA vasculitis. Clin J Am Soc Nephrol. 2014 Apr; 9(4):736-44. PMID: 24626432.
    Citations: 26     Fields:    Translation:HumansCells
  39. Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R. A systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab. 2014 Apr 15; 306(8):E854-68. PMID: 24518676.
    Citations: 11     Fields:    Translation:Animals
  40. Kalim S, Clish CB, Wenger J, Elmariah S, Yeh RW, Deferio JJ, Pierce K, Deik A, Gerszten RE, Thadhani R, Rhee EP. A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients. J Am Heart Assoc. 2013 Dec 05; 2(6):e000542. PMID: 24308938.
    Citations: 32     Fields:    Translation:Humans
  41. Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten RE. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct; 123(10):4309-17. PMID: 24091325.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  42. Walford GA, Davis J, Warner AS, Ackerman RJ, Billings LK, Chamarthi B, Fanelli RR, Hernandez AM, Huang C, Khan SQ, Littleton KR, Lo J, McCarthy RM, Rhee EP, Deik A, Stolerman E, Taylor A, Hudson MS, Wang TJ, Altshuler D, Grant RW, Clish CB, Gerszten RE, Florez JC. Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus. Metabolism. 2013 Dec; 62(12):1772-8. PMID: 23953891.
    Citations: 17     Fields:    Translation:Humans
  43. Rhee EP, Ho JE, Chen MH, Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O'Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, Vasan RS, Florez JC, Clish C, Yeh JR, Wang TJ, Gerszten RE. A genome-wide association study of the human metabolome in a community-based cohort. Cell Metab. 2013 Jul 02; 18(1):130-43. PMID: 23823483.
    Citations: 48     Fields:    Translation:Humans
  44. Rhee EP, Clish CB, Ghorbani A, Larson MG, Elmariah S, McCabe E, Yang Q, Cheng S, Pierce K, Deik A, Souza AL, Farrell L, Domos C, Yeh RW, Palacios I, Rosenfield K, Vasan RS, Florez JC, Wang TJ, Fox CS, Gerszten RE. A combined epidemiologic and metabolomic approach improves CKD prediction. J Am Soc Nephrol. 2013 Jul; 24(8):1330-8. PMID: 23687356.
    Citations: 46     Fields:    Translation:Humans
  45. Ho JE, Larson MG, Vasan RS, Ghorbani A, Cheng S, Rhee EP, Florez JC, Clish CB, Gerszten RE, Wang TJ. Metabolite profiles during oral glucose challenge. Diabetes. 2013 Aug; 62(8):2689-98. PMID: 23382451.
    Citations: 35     Fields:    Translation:Humans
  46. Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D, Palma MJ, Roberts LD, Dejam A, Souza AL, Deik AA, Magnusson M, Fox CS, O'Donnell CJ, Vasan RS, Melander O, Clish CB, Gerszten RE, Wang TJ. Metabolite profiling identifies pathways associated with metabolic risk in humans. Circulation. 2012 May 08; 125(18):2222-31. PMID: 22496159.
    Citations: 124     Fields:    Translation:HumansAnimals
  47. Rhee EP, Scott JA, Dighe AS. Case records of the Massachusetts General Hospital. Case 4-2012. A 37-year-old man with muscle pain, weakness, and weight loss. N Engl J Med. 2012 Feb 09; 366(6):553-60. PMID: 22316449.
    Citations: 4     Fields:    Translation:Humans
  48. Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA. Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol. 2012 Jan 15; 14(2):209-19. PMID: 22246346.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  49. Rhee EP, Gerszten RE. Metabolomics and cardiovascular biomarker discovery. Clin Chem. 2012 Jan; 58(1):139-47. PMID: 22110018.
    Citations: 49     Fields:    Translation:Humans
  50. Rhee EP, Thadhani R. New insights into uremia-induced alterations in metabolic pathways. Curr Opin Nephrol Hypertens. 2011 Nov; 20(6):593-8. PMID: 21885966.
    Citations: 10     Fields:    Translation:Humans
  51. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011 Apr; 17(4):448-53. PMID: 21423183.
    Citations: 617     Fields:    Translation:Humans
  52. Rhee EP, Cheng S, Larson MG, Walford GA, Lewis GD, McCabe E, Yang E, Farrell L, Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, Gerszten RE. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest. 2011 Apr; 121(4):1402-11. PMID: 21403394.
    Citations: 136     Fields:    Translation:HumansCells
  53. Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010 May 26; 2(33):33ra37. PMID: 20505214.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  54. Rhee EP, Laliberte KA, Niles JL. Rituximab as maintenance therapy for anti-neutrophil cytoplasmic antibody-associated vasculitis. Clin J Am Soc Nephrol. 2010 Aug; 5(8):1394-400. PMID: 20498238.
    Citations: 24     Fields:    Translation:HumansCells
  55. Rhee EP, Souza A, Farrell L, Pollak MR, Lewis GD, Steele DJ, Thadhani R, Clish CB, Greka A, Gerszten RE. Metabolite profiling identifies markers of uremia. J Am Soc Nephrol. 2010 Jun; 21(6):1041-1051. PMID: 20378825.
    Citations: 49     Fields:    Translation:Humans
  56. Barth MC, Ahluwalia N, Anderson TJ, Hardy GJ, Sinha S, Alvarez-Cardona JA, Pruitt IE, Rhee EP, Colvin RA, Gerszten RE. Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions. J Biol Chem. 2009 Jul 17; 284(29):19189-95. PMID: 19473985.
    Citations: 37     Fields:    Translation:HumansCells
  57. Gutierrez O, Isakova T, Rhee E, Shah A, Holmes J, Collerone G, Jüppner H, Wolf M. Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol. 2005 Jul; 16(7):2205-15. PMID: 15917335.
    Citations: 246     Fields:    Translation:Humans
  58. Natarajan K, Jackson BM, Rhee E, Hinnebusch AG. yTAFII61 has a general role in RNA polymerase II transcription and is required by Gcn4p to recruit the SAGA coactivator complex. Mol Cell. 1998 Nov; 2(5):683-92. PMID: 9844640.
    Citations: 36     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.