Harvard Catalyst Profiles

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Konrad Hochedlinger, Ph.D.

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Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HD103612 (HOCHEDLINGER, KONRAD) Apr 1, 2021 - Mar 31, 2026
    NIH
    Dissecting mechanistic links between MAPK signaling, genomic hypomethylation and naive pluripotency
    Role: Principal Investigator
  2. R01AR077695 (HOCHEDLINGER, KONRAD) Aug 15, 2020 - May 31, 2025
    NIH
    Investigating the direct reprogramming of fibroblasts into skeletal muscle progenitors
    Role: Principal Investigator
  3. R21CA194521 (HOCHEDLINGER, KONRAD) Mar 4, 2016 - Feb 28, 2018
    NIH
    Dissecting the molecular and functional role of Sox2 in synovial sarcoma
    Role: Principal Investigator
  4. R01DK096034 (HOCHEDLINGER, KONRAD) Jul 1, 2012 - Jun 30, 2016
    NIH
    Role of Sox2 in stomach development, regeneration and cancer
    Role: Principal Investigator
  5. R01HD058013 (HOCHEDLINGER, KONRAD) Jun 1, 2008 - May 31, 2021
    NIH
    Transcription Factor Induced Reprogramming
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 154 total Publications Show all
  1. Gorelov R, Hochedlinger K. A cellular identity crisis? Plasticity changes during aging and rejuvenation. Genes Dev. 2024 Oct 16; 38(17-20):823-842. PMID: 39293862; PMCID: PMC11535162.
    Citations:
    Fields: MolMolecular BiologyTranslation:HumansAnimals
  2. Yagi M, Horng JE, Hochedlinger K. Manipulating cell fate through reprogramming: approaches and applications. Development. 2024 Oct 01; 151(19). PMID: 39348466; PMCID: PMC11463964.
    Citations: 1
    Fields: BioBiologyEmbEmbryologyTranslation:HumansAnimalsCells
  3. Gorelov R, Weiner A, Huebner A, Yagi M, Haghani A, Brooke R, Horvath S, Hochedlinger K. Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks. Stem Cell Reports. 2024 Sep 10; 19(9):1242-1254. PMID: 39178844; PMCID: PMC11411293.
    Citations:
    Fields: CelCell BiologyTranslation:AnimalsCells
  4. LeBleu VS, Kanasaki K, Lovisa S, Alge JL, Kim J, Chen Y, Teng Y, Gerami-Naini B, Sugimoto H, Kato N, Revuelta I, Grau N, Sleeman JP, Taduri G, Kizu A, Rafii S, Hochedlinger K, Quaggin SE, Kalluri R. Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome. Life Sci Alliance. 2024 Jun; 7(6). PMID: 38561223; PMCID: PMC10985218.
    Citations: 1
    Fields: BioBiochemistryCelCell BiologyMolMolecular BiologyTranslation:AnimalsCells
  5. Hoetker MS, Yagi M, Di Stefano B, Langerman J, Cristea S, Wong LP, Huebner AJ, Charlton J, Deng W, Haggerty C, Sadreyev RI, Meissner A, Michor F, Plath K, Hochedlinger K. H3K36 methylation maintains cell identity by regulating opposing lineage programmes. Nat Cell Biol. 2023 Aug; 25(8):1121-1134. PMID: 37460697; PMCID: PMC10896483.
    Citations: 10
    Fields: CelCell BiologyTranslation:Cells
  6. Hochedlinger K, Wagner EF, Sabapathy K. Correction: Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis. Oncogene. 2023 Jun; 42(25):2099-2100. PMID: 37258744.
    Citations:
    Fields: MolMolecular BiologyNeoNeoplasms
  7. Huebner AJ, Gorelov RA, Deviatiiarov R, Demharter S, Kull T, Walsh RM, Taylor MS, Steiger S, Mullen JT, Kharchenko PV, Hochedlinger K. Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro. Nat Cell Biol. 2023 03; 25(3):390-403. PMID: 36717627.
    Citations: 5
    Fields: CelCell BiologyTranslation:Cells
  8. Generoso SF, Neguembor MV, Hershberg EA, Sadreyev RI, Kurimoto K, Yabuta Y, Ricci R, Audergon P, Bauer M, Saitou M, Hochedlinger K, Beliveau BJ, Cosma MP, Lee JT, Payer B. Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming. Proc Natl Acad Sci U S A. 2023 Jan 24; 120(4):e2213810120. PMID: 36669113; PMCID: PMC9942853.
    Citations: 5
    Fields: SciScienceTranslation:AnimalsCells
  9. Witkowski MT, Lee S, Wang E, Lee AK, Talbot A, Ma C, Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG, Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J, Aifantis I. NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nat Immunol. 2022 10; 23(10):1424-1432. PMID: 36138187; PMCID: PMC9611506.
    Citations: 12
    Fields: AllAllergy and ImmunologyTranslation:HumansCells
  10. Franklin R, Guo Y, He S, Chen M, Ji F, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco MA, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev RI, Murn J, Volk A, Cheloufi S. Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity. Nat Commun. 2022 04 29; 13(1):2350. PMID: 35487911; PMCID: PMC9054786.
    Citations: 10
    Fields: BioBiologySciScienceTranslation:Cells
  11. Singh H, Seruggia D, Madha S, Saxena M, Nagaraja AK, Wu Z, Zhou J, Huebner AJ, Maglieri A, Wezenbeek J, Hochedlinger K, Orkin SH, Bass AJ, Hornick JL, Shivdasani RA. Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer. Genes Dev. 2022 01 01; 36(1-2):38-52. PMID: 34969824; PMCID: PMC8763054.
    Citations: 7
    Fields: MolMolecular BiologyTranslation:Animals
  12. Blanco MA, Sykes DB, Gu L, Wu M, Petroni R, Karnik R, Wawer M, Rico J, Li H, Jacobus WD, Jambhekar A, Cheloufi S, Meissner A, Hochedlinger K, Scadden DT, Shi Y. Chromatin-state barriers enforce an irreversible mammalian cell fate decision. Cell Rep. 2021 11 09; 37(6):109967. PMID: 34758323.
    Citations: 29
    Fields: CelCell BiologyMolMolecular BiologyTranslation:AnimalsCells
  13. Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ. Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. Genes Dev. 2021 11 01; 35(21-22):1527-1547. PMID: 34711655; PMCID: PMC8559676.
    Citations: 11
    Fields: MolMolecular BiologyTranslation:HumansCells
  14. Yagi M, Ji F, Charlton J, Cristea S, Messemer K, Horwitz N, Di Stefano B, Tsopoulidis N, Hoetker MS, Huebner AJ, Bar-Nur O, Almada AE, Yamamoto M, Patelunas A, Goldhamer DJ, Wagers AJ, Michor F, Meissner A, Sadreyev RI, Hochedlinger K. Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells. Genes Dev. 2021 09 01; 35(17-18):1209-1228. PMID: 34413137; PMCID: PMC8415322.
    Citations: 19
    Fields: MolMolecular BiologyTranslation:AnimalsCells
  15. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 12; 588(7836):124-129. PMID: 33268865; PMCID: PMC7752134.
    Citations: 284
    Fields: SciScienceTranslation:HumansAnimalsCells
  16. Shu Y, Li W, Huang M, Quan YZ, Scheffer D, Tian C, Tao Y, Liu X, Hochedlinger K, Indzhykulian AA, Wang Z, Li H, Chen ZY. Renewed proliferation in adult mouse cochlea and regeneration of hair cells. Nat Commun. 2019 12 04; 10(1):5530. PMID: 31797926; PMCID: PMC6892913.
    Citations: 50
    Fields: BioBiologySciScienceTranslation:HumansAnimalsCells
  17. Brumbaugh J, Di Stefano B, Hochedlinger K. Reprogramming: identifying the mechanisms that safeguard cell identity. Development. 2019 12 02; 146(23). PMID: 31792064; PMCID: PMC6918747.
    Citations: 24
    Fields: BioBiologyEmbEmbryologyTranslation:HumansAnimalsCells
  18. Brumbaugh J, Kim IS, Ji F, Huebner AJ, Di Stefano B, Schwarz BA, Charlton J, Coffey A, Choi J, Walsh RM, Schindler JW, Anselmo A, Meissner A, Sadreyev RI, Bernstein BE, Hock H, Hochedlinger K. Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo. Nat Cell Biol. 2019 11; 21(11):1449-1461. PMID: 31659274; PMCID: PMC6858577.
    Citations: 33
    Fields: CelCell BiologyTranslation:AnimalsCells
  19. Di Stefano B, Luo EC, Haggerty C, Aigner S, Charlton J, Brumbaugh J, Ji F, Rabano Jiménez I, Clowers KJ, Huebner AJ, Clement K, Lipchina I, de Kort MAC, Anselmo A, Pulice J, Gerli MFM, Gu H, Gygi SP, Sadreyev RI, Meissner A, Yeo GW, Hochedlinger K. The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. Cell Stem Cell. 2019 11 07; 25(5):622-638.e13. PMID: 31588046; PMCID: PMC7247364.
    Citations: 60
    Fields: CelCell BiologyTranslation:HumansAnimalsCells
  20. Yagi M, Kabata M, Ukai T, Ohta S, Tanaka A, Shimada Y, Sugimoto M, Araki K, Okita K, Woltjen K, Hochedlinger K, Yamamoto T, Yamada Y. De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency. Stem Cell Reports. 2019 05 14; 12(5):1113-1128. PMID: 31056481; PMCID: PMC6524733.
    Citations: 14
    Fields: CelCell BiologyTranslation:HumansAnimalsCells
  21. Schiebinger G, Shu J, Tabaka M, Cleary B, Subramanian V, Solomon A, Gould J, Liu S, Lin S, Berube P, Lee L, Chen J, Brumbaugh J, Rigollet P, Hochedlinger K, Jaenisch R, Regev A, Lander ES. Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming. Cell. 2019 Mar 07; 176(6):1517. PMID: 30849376.
    Citations: 45
    Fields: CelCell Biology
  22. Schiebinger G, Shu J, Tabaka M, Cleary B, Subramanian V, Solomon A, Gould J, Liu S, Lin S, Berube P, Lee L, Chen J, Brumbaugh J, Rigollet P, Hochedlinger K, Jaenisch R, Regev A, Lander ES. Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming. Cell. 2019 02 07; 176(4):928-943.e22. PMID: 30712874; PMCID: PMC6402800.
    Citations: 225
    Fields: CelCell BiologyTranslation:AnimalsCells
  23. Sardina JL, Collombet S, Tian TV, Gómez A, Di Stefano B, Berenguer C, Brumbaugh J, Stadhouders R, Segura-Morales C, Gut M, Gut IG, Heath S, Aranda S, Di Croce L, Hochedlinger K, Thieffry D, Graf T. Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate. Cell Stem Cell. 2018 Dec 06; 23(6):905-906. PMID: 30526885.
    Citations: 34
    Fields: CelCell Biology
  24. Di Stefano B, Hochedlinger K. Novel Roles for SUMOylation in Cellular Plasticity. Trends Cell Biol. 2018 12; 28(12):971-973. PMID: 30463679; PMCID: PMC6456908.
    Citations: 1
    Fields: CelCell BiologyTranslation:Cells
  25. Sardina JL, Collombet S, Tian TV, Gómez A, Di Stefano B, Berenguer C, Brumbaugh J, Stadhouders R, Segura-Morales C, Gut M, Gut IG, Heath S, Aranda S, Di Croce L, Hochedlinger K, Thieffry D, Graf T. Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate. Cell Stem Cell. 2018 11 01; 23(5):727-741.e9. PMID: 30220521.
    Citations: 86
    Fields: CelCell BiologyTranslation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.