Harvard Catalyst Profiles

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Konrad Hochedlinger, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD103612 (HOCHEDLINGER, KONRAD) Apr 1, 2021 - Mar 31, 2026
    NIH
    Dissecting mechanistic links between MAPK signaling, genomic hypomethylation and naive pluripotency
    Role: Principal Investigator
  2. R01AR077695 (HOCHEDLINGER, KONRAD) Aug 15, 2020 - May 31, 2025
    NIH
    Investigating the direct reprogramming of fibroblasts into skeletal muscle progenitors
    Role: Principal Investigator
  3. R21CA194521 (HOCHEDLINGER, KONRAD) Mar 4, 2016 - Feb 28, 2018
    NIH
    Dissecting the molecular and functional role of Sox2 in synovial sarcoma
    Role: Principal Investigator
  4. R01DK096034 (HOCHEDLINGER, KONRAD) Jul 1, 2012 - Jun 30, 2016
    NIH
    Role of Sox2 in stomach development, regeneration and cancer
    Role: Principal Investigator
  5. R01HD058013 (HOCHEDLINGER, KONRAD) Jun 1, 2008 - May 31, 2021
    NIH
    Transcription Factor Induced Reprogramming
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Singh H, Seruggia D, Madha S, Saxena M, Nagaraja AK, Wu Z, Zhou J, Huebner AJ, Maglieri A, Wezenbeek J, Hochedlinger K, Orkin SH, Bass AJ, Hornick JL, Shivdasani RA. Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer. Genes Dev. 2022 01 01; 36(1-2):38-52. PMID: 34969824.
    Citations:    Fields:    
  2. Blanco MA, Sykes DB, Gu L, Wu M, Petroni R, Karnik R, Wawer M, Rico J, Li H, Jacobus WD, Jambhekar A, Cheloufi S, Meissner A, Hochedlinger K, Scadden DT, Shi Y. Chromatin-state barriers enforce an irreversible mammalian cell fate decision. Cell Rep. 2021 11 09; 37(6):109967. PMID: 34758323.
    Citations: 3     Fields:    Translation:AnimalsCells
  3. Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ. Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. Genes Dev. 2021 11 01; 35(21-22):1527-1547. PMID: 34711655.
    Citations: 1     Fields:    
  4. Yagi M, Ji F, Charlton J, Cristea S, Messemer K, Horwitz N, Di Stefano B, Tsopoulidis N, Hoetker MS, Huebner AJ, Bar-Nur O, Almada AE, Yamamoto M, Patelunas A, Goldhamer DJ, Wagers AJ, Michor F, Meissner A, Sadreyev RI, Hochedlinger K. Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells. Genes Dev. 2021 09 01; 35(17-18):1209-1228. PMID: 34413137.
    Citations: 1     Fields:    
  5. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 12; 588(7836):124-129. PMID: 33268865.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  6. Shu Y, Li W, Huang M, Quan YZ, Scheffer D, Tian C, Tao Y, Liu X, Hochedlinger K, Indzhykulian AA, Wang Z, Li H, Chen ZY. Renewed proliferation in adult mouse cochlea and regeneration of hair cells. Nat Commun. 2019 12 04; 10(1):5530. PMID: 31797926.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  7. Brumbaugh J, Di Stefano B, Hochedlinger K. Reprogramming: identifying the mechanisms that safeguard cell identity. Development. 2019 12 02; 146(23). PMID: 31792064.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  8. Brumbaugh J, Kim IS, Ji F, Huebner AJ, Di Stefano B, Schwarz BA, Charlton J, Coffey A, Choi J, Walsh RM, Schindler JW, Anselmo A, Meissner A, Sadreyev RI, Bernstein BE, Hock H, Hochedlinger K. Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo. Nat Cell Biol. 2019 11; 21(11):1449-1461. PMID: 31659274.
    Citations: 15     Fields:    Translation:AnimalsCells
  9. Di Stefano B, Luo EC, Haggerty C, Aigner S, Charlton J, Brumbaugh J, Ji F, Rabano Jiménez I, Clowers KJ, Huebner AJ, Clement K, Lipchina I, de Kort MAC, Anselmo A, Pulice J, Gerli MFM, Gu H, Gygi SP, Sadreyev RI, Meissner A, Yeo GW, Hochedlinger K. The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. Cell Stem Cell. 2019 11 07; 25(5):622-638.e13. PMID: 31588046.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  10. Yagi M, Kabata M, Ukai T, Ohta S, Tanaka A, Shimada Y, Sugimoto M, Araki K, Okita K, Woltjen K, Hochedlinger K, Yamamoto T, Yamada Y. De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency. Stem Cell Reports. 2019 05 14; 12(5):1113-1128. PMID: 31056481.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  11. Schiebinger G, Shu J, Tabaka M, Cleary B, Subramanian V, Solomon A, Gould J, Liu S, Lin S, Berube P, Lee L, Chen J, Brumbaugh J, Rigollet P, Hochedlinger K, Jaenisch R, Regev A, Lander ES. Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming. Cell. 2019 Mar 07; 176(6):1517. PMID: 30849376.
    Citations: 23     Fields:    
  12. Schiebinger G, Shu J, Tabaka M, Cleary B, Subramanian V, Solomon A, Gould J, Liu S, Lin S, Berube P, Lee L, Chen J, Brumbaugh J, Rigollet P, Hochedlinger K, Jaenisch R, Regev A, Lander ES. Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming. Cell. 2019 02 07; 176(4):928-943.e22. PMID: 30712874.
    Citations: 79     Fields:    Translation:AnimalsCells
  13. Sardina JL, Collombet S, Tian TV, Gómez A, Di Stefano B, Berenguer C, Brumbaugh J, Stadhouders R, Segura-Morales C, Gut M, Gut IG, Heath S, Aranda S, Di Croce L, Hochedlinger K, Thieffry D, Graf T. Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate. Cell Stem Cell. 2018 Dec 06; 23(6):905-906. PMID: 30526885.
    Citations: 19     Fields:    
  14. Di Stefano B, Hochedlinger K. Novel Roles for SUMOylation in Cellular Plasticity. Trends Cell Biol. 2018 12; 28(12):971-973. PMID: 30463679.
    Citations: 1     Fields:    Translation:Cells
  15. Sardina JL, Collombet S, Tian TV, Gómez A, Di Stefano B, Berenguer C, Brumbaugh J, Stadhouders R, Segura-Morales C, Gut M, Gut IG, Heath S, Aranda S, Di Croce L, Hochedlinger K, Thieffry D, Graf T. Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate. Cell Stem Cell. 2018 11 01; 23(5):727-741.e9. PMID: 30220521.
    Citations: 53     Fields:    Translation:AnimalsCells
  16. Di Stefano B, Ueda M, Sabri S, Brumbaugh J, Huebner AJ, Sahakyan A, Clement K, Clowers KJ, Erickson AR, Shioda K, Gygi SP, Gu H, Shioda T, Meissner A, Takashima Y, Plath K, Hochedlinger K. Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells. Nat Methods. 2018 09; 15(9):732-740. PMID: 30127506.
    Citations: 25     Fields:    Translation:HumansCells
  17. Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K. Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming. Cell Stem Cell. 2018 Aug 02; 23(2):289-305.e5. PMID: 30017590.
    Citations: 23     Fields:    Translation:AnimalsCells
  18. Du P, Pirouz M, Choi J, Huebner AJ, Clement K, Meissner A, Hochedlinger K, Gregory RI. An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition. Cell Stem Cell. 2018 Jun 01; 22(6):851-864.e5. PMID: 29804889.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  19. Bar-Nur O, Gerli MFM, Di Stefano B, Almada AE, Galvin A, Coffey A, Huebner AJ, Feige P, Verheul C, Cheung P, Payzin-Dogru D, Paisant S, Anselmo A, Sadreyev RI, Ott HC, Tajbakhsh S, Rudnicki MA, Wagers AJ, Hochedlinger K. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 05 08; 10(5):1505-1521. PMID: 29742392.
    Citations: 23     Fields:    Translation:AnimalsCells
  20. Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 01 25; 172(3):629-631. PMID: 29373832.
    Citations: 10     Fields:    
  21. Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 01 11; 172(1-2):106-120.e21. PMID: 29249356.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  22. Choi J, Huebner AJ, Clement K, Walsh RM, Savol A, Lin K, Gu H, Di Stefano B, Brumbaugh J, Kim SY, Sharif J, Rose CM, Mohammad A, Odajima J, Charron J, Shioda T, Gnirke A, Gygi S, Koseki H, Sadreyev RI, Xiao A, Meissner A, Hochedlinger K. Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells. Nature. 2017 08 10; 548(7666):219-223. PMID: 28746311.
    Citations: 84     Fields:    Translation:AnimalsCells
  23. Cheloufi S, Hochedlinger K. Emerging roles of the histone chaperone CAF-1 in cellular plasticity. Curr Opin Genet Dev. 2017 Oct; 46:83-94. PMID: 28692904.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  24. Bhagat TD, Chen S, Bartenstein M, Barlowe AT, Von Ahrens D, Choudhary GS, Tivnan P, Amin E, Marcondes AM, Sanders MA, Hoogenboezem RM, Kambhampati S, Ramachandra N, Mantzaris I, Sukrithan V, Laurence R, Lopez R, Bhagat P, Giricz O, Sohal D, Wickrema A, Yeung C, Gritsman K, Aplan P, Hochedlinger K, Yu Y, Pradhan K, Zhang J, Greally JM, Mukherjee S, Pellagatti A, Boultwood J, Will B, Steidl U, Raaijmakers MHGP, Deeg HJ, Kharas MG, Verma A. Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/ß-Catenin Activation. Cancer Res. 2017 09 15; 77(18):4846-4857. PMID: 28684528.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  25. Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K. Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice. Nat Commun. 2017 05 09; 8:15142. PMID: 28485378.
    Citations: 11     Fields:    Translation:AnimalsCells
  26. Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, Park PJ, Gygi SP, Meissner A, Hochedlinger K. DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells. Cell Stem Cell. 2017 05 04; 20(5):706-719.e7. PMID: 28366588.
    Citations: 30     Fields:    Translation:AnimalsCells
  27. Liu LL, Brumbaugh J, Bar-Nur O, Smith Z, Stadtfeld M, Meissner A, Hochedlinger K, Michor F. Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells. Cell Rep. 2016 12 20; 17(12):3395-3406. PMID: 28009305.
    Citations: 5     Fields:    Translation:HumansCells
  28. Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, Shivdasani RA, Hochedlinger K. Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell Rep. 2016 08 16; 16(7):1929-41. PMID: 27498859.
    Citations: 32     Fields:    Translation:AnimalsCells
  29. Miyoshi N, Stel JM, Shioda K, Qu N, Odajima J, Mitsunaga S, Zhang X, Nagano M, Hochedlinger K, Isselbacher KJ, Shioda T. Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9545-50. PMID: 27486249.
    Citations: 17     Fields:    Translation:AnimalsCells
  30. TeSlaa T, Chaikovsky AC, Lipchina I, Escobar SL, Hochedlinger K, Huang J, Graeber TG, Braas D, Teitell MA. a-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells. Cell Metab. 2016 09 13; 24(3):485-493. PMID: 27476976.
    Citations: 97     Fields:    Translation:HumansCells
  31. Di Stefano B, Hochedlinger K. Cell reprogramming: Brain versus brawn. Nature. 2016 06 16; 534(7607):332-3. PMID: 27281201.
    Citations: 1     Fields:    Translation:AnimalsCells
  32. Beagan JA, Gilgenast TG, Kim J, Plona Z, Norton HK, Hu G, Hsu SC, Shields EJ, Lyu X, Apostolou E, Hochedlinger K, Corces VG, Dekker J, Phillips-Cremins JE. Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming. Cell Stem Cell. 2016 05 05; 18(5):611-24. PMID: 27152443.
    Citations: 49     Fields:    Translation:AnimalsCells
  33. Borkent M, Bennett BD, Lackford B, Bar-Nur O, Brumbaugh J, Wang L, Du Y, Fargo DC, Apostolou E, Cheloufi S, Maherali N, Elledge SJ, Hu G, Hochedlinger K. A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2. Stem Cell Reports. 2016 05 10; 6(5):704-716. PMID: 26947976.
    Citations: 23     Fields:    Translation:HumansCells
  34. De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, Borkent M, Krupalnik V, Lujan E, Wernig M, Hanna JH, Hochedlinger K, Pei D, Jaenisch R, Deng H, Orkin SH, Park PJ, Daley GQ. Corrigendum: Failure to replicate the STAP cell phenomenon. Nature. 2016 Mar 17; 531(7594):400. PMID: 26675720.
    Citations:    Fields:    
  35. De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ. Corrigendum: Hallmarks of pluripotency. Nature. 2016 Mar 17; 531(7594):400. PMID: 26675727.
    Citations: 1     Fields:    
  36. Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, Rathert P, Jude J, Ferrari F, Blanco A, Fellner M, Wenzel D, Zinner M, Vidal SE, Bell O, Stadtfeld M, Chang HY, Almouzni G, Lowe SW, Rinn J, Wernig M, Aravin A, Shi Y, Park PJ, Penninger JM, Zuber J, Hochedlinger K. The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 2015 Dec 10; 528(7581):218-24. PMID: 26659182.
    Citations: 112     Fields:    Translation:AnimalsCells
  37. Hochedlinger K, Jaenisch R. Induced Pluripotency and Epigenetic Reprogramming. Cold Spring Harb Perspect Biol. 2015 Dec 01; 7(12). PMID: 26626939.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  38. Choi J, Lee S, Mallard W, Clement K, Tagliazucchi GM, Lim H, Choi IY, Ferrari F, Tsankov AM, Pop R, Lee G, Rinn JL, Meissner A, Park PJ, Hochedlinger K. A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs. Nat Biotechnol. 2015 Nov; 33(11):1173-81. PMID: 26501951.
    Citations: 113     Fields:    Translation:HumansCells
  39. Li L, Walsh RM, Wagh V, James MF, Beauchamp RL, Chang YS, Gusella JF, Hochedlinger K, Ramesh V. Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency. PLoS One. 2015; 10(10):e0140192. PMID: 26445504.
    Citations: 6     Fields:    Translation:AnimalsCells
  40. De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ. Hallmarks of pluripotency. Nature. 2015 Sep 24; 525(7570):469-78. PMID: 26399828.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  41. De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, Borkent M, Krupalnik V, Lujan E, Wernig M, Hanna JH, Hochedlinger K, Pei D, Jaenisch R, Deng H, Orkin SH, Park PJ, Daley GQ. Failure to replicate the STAP cell phenomenon. Nature. 2015 Sep 24; 525(7570):E6-9. PMID: 26399835.
    Citations: 14     Fields:    Translation:AnimalsCells
  42. Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, Choe J, Jun DL, Shen X, Gregory RI, Daley GQ, Meissner A, Kellis M, Hochedlinger K, Kim J, Orkin SH. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep. 2015 Sep 01; 12(9):1456-70. PMID: 26299972.
    Citations: 33     Fields:    Translation:AnimalsCells
  43. Bar-Nur O, Verheul C, Sommer AG, Brumbaugh J, Schwarz BA, Lipchina I, Huebner AJ, Mostoslavsky G, Hochedlinger K. Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage. Nat Biotechnol. 2015 Jul; 33(7):761-8. PMID: 26098450.
    Citations: 58     Fields:    Translation:AnimalsCells
  44. Etchegaray JP, Chavez L, Huang Y, Ross KN, Choi J, Martinez-Pastor B, Walsh RM, Sommer CA, Lienhard M, Gladden A, Kugel S, Silberman DM, Ramaswamy S, Mostoslavsky G, Hochedlinger K, Goren A, Rao A, Mostoslavsky R. The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine. Nat Cell Biol. 2015 May; 17(5):545-57. PMID: 25915124.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  45. Bar-Nur O, Brumbaugh J, Verheul C, Apostolou E, Pruteanu-Malinici I, Walsh RM, Ramaswamy S, Hochedlinger K. Small molecules facilitate rapid and synchronous iPSC generation. Nat Methods. 2014 Nov; 11(11):1170-6. PMID: 25262205.
    Citations: 42     Fields:    Translation:AnimalsCells
  46. Wu T, Liu Y, Wen D, Tseng Z, Tahmasian M, Zhong M, Rafii S, Stadtfeld M, Hochedlinger K, Xiao A. Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs. Cell Stem Cell. 2014 Sep 04; 15(3):281-294. PMID: 25192463.
    Citations: 28     Fields:    Translation:AnimalsCells
  47. West JA, Cook A, Alver BH, Stadtfeld M, Deaton AM, Hochedlinger K, Park PJ, Tolstorukov MY, Kingston RE. Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming. Nat Commun. 2014 Aug 27; 5:4719. PMID: 25158628.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  48. Vanner RJ, Remke M, Gallo M, Selvadurai HJ, Coutinho F, Lee L, Kushida M, Head R, Morrissy S, Zhu X, Aviv T, Voisin V, Clarke ID, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJ, Marra MA, Malkin D, Northcott PA, Kool M, Pfister SM, Bader G, Hochedlinger K, Korshunov A, Taylor MD, Dirks PB. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell. 2014 Jul 14; 26(1):33-47. PMID: 24954133.
    Citations: 138     Fields:    Translation:AnimalsCells
  49. Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H. Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med. 2014 May 05; 211(5):909-27. PMID: 24711581.
    Citations: 34     Fields:    Translation:AnimalsCells
  50. Bramhall NF, Shi F, Arnold K, Hochedlinger K, Edge AS. Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. Stem Cell Reports. 2014 Mar 11; 2(3):311-22. PMID: 24672754.
    Citations: 99     Fields:    Translation:AnimalsCells
  51. Schwarz BA, Bar-Nur O, Silva JC, Hochedlinger K. Nanog is dispensable for the generation of induced pluripotent stem cells. Curr Biol. 2014 Feb 03; 24(3):347-50. PMID: 24461999.
    Citations: 36     Fields:    Translation:AnimalsCells
  52. Das PP, Shao Z, Beyaz S, Apostolou E, Pinello L, De Los Angeles A, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, Daley G, Hochedlinger K, Kim J, Orkin SH. Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Mol Cell. 2014 01 09; 53(1):32-48. PMID: 24361252.
    Citations: 64     Fields:    Translation:AnimalsCells
  53. Brack AS, Hochedlinger K. ISSCR 2013: back to Bean Town. Stem Cell Reports. 2013; 1(6):479-85. PMID: 25847520.
    Citations:    Fields:    Translation:HumansAnimalsCells
  54. Wang L, Miao YL, Zheng X, Lackford B, Zhou B, Han L, Yao C, Ward JM, Burkholder A, Lipchina I, Fargo DC, Hochedlinger K, Shi Y, Williams CJ, Hu G. The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Cell Stem Cell. 2013 Dec 05; 13(6):676-90. PMID: 24315442.
    Citations: 38     Fields:    Translation:AnimalsCells
  55. Ferrari F, Apostolou E, Park PJ, Hochedlinger K. Rearranging the chromatin for pluripotency. Cell Cycle. 2014; 13(2):167-8. PMID: 24241209.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  56. Apostolou E, Hochedlinger K. Chromatin dynamics during cellular reprogramming. Nature. 2013 Oct 24; 502(7472):462-71. PMID: 24153299.
    Citations: 176     Fields:    Translation:HumansAnimalsCells
  57. Brumbaugh J, Hochedlinger K. Removing reprogramming roadblocks: Mbd3 depletion allows deterministic iPSC generation. Cell Stem Cell. 2013 Oct 03; 13(4):379-81. PMID: 24094318.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  58. Walsh RM, Hochedlinger K. A variant CRISPR-Cas9 system adds versatility to genome engineering. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):15514-5. PMID: 24014593.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  59. Apostolou E, Ferrari F, Walsh RM, Bar-Nur O, Stadtfeld M, Cheloufi S, Stuart HT, Polo JM, Ohsumi TK, Borowsky ML, Kharchenko PV, Park PJ, Hochedlinger K. Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell Stem Cell. 2013 Jun 06; 12(6):699-712. PMID: 23665121.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  60. Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I. Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development. 2013 Apr; 140(7):1424-32. PMID: 23462476.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  61. Wang S, Bates J, Li X, Schanz S, Chandler-Militello D, Levine C, Maherali N, Studer L, Hochedlinger K, Windrem M, Goldman SA. Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination. Cell Stem Cell. 2013 Feb 07; 12(2):252-64. PMID: 23395447.
    Citations: 255     Fields:    Translation:HumansAnimalsCells
  62. Sarkar A, Hochedlinger K. The sox family of transcription factors: versatile regulators of stem and progenitor cell fate. Cell Stem Cell. 2013 Jan 03; 12(1):15-30. PMID: 23290134.
    Citations: 370     Fields:    Translation:HumansAnimalsCells
  63. Hirata A, Utikal J, Yamashita S, Aoki H, Watanabe A, Yamamoto T, Okano H, Bardeesy N, Kunisada T, Ushijima T, Hara A, Jaenisch R, Hochedlinger K, Yamada Y. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development. 2013 Jan 01; 140(1):66-75. PMID: 23222438.
    Citations: 39     Fields:    Translation:AnimalsCells
  64. Hansson J, Rafiee MR, Reiland S, Polo JM, Gehring J, Okawa S, Huber W, Hochedlinger K, Krijgsveld J. Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency. Cell Rep. 2012 Dec 27; 2(6):1579-92. PMID: 23260666.
    Citations: 125     Fields:    Translation:AnimalsCells
  65. Polo JM, Anderssen E, Walsh RM, Schwarz BA, Nefzger CM, Lim SM, Borkent M, Apostolou E, Alaei S, Cloutier J, Bar-Nur O, Cheloufi S, Stadtfeld M, Figueroa ME, Robinton D, Natesan S, Melnick A, Zhu J, Ramaswamy S, Hochedlinger K. A molecular roadmap of reprogramming somatic cells into iPS cells. Cell. 2012 Dec 21; 151(7):1617-32. PMID: 23260147.
    Citations: 382     Fields:    Translation:HumansAnimalsCells
  66. Cheloufi S, Hochedlinger K. Reproductive biology: Stem cells bear eggs. Nature. 2012 Nov 22; 491(7425):535-6. PMID: 23172212.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  67. Buckley SM, Aranda-Orgilles B, Strikoudis A, Apostolou E, Loizou E, Moran-Crusio K, Farnsworth CL, Koller AA, Dasgupta R, Silva JC, Stadtfeld M, Hochedlinger K, Chen EI, Aifantis I. Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell. 2012 Dec 07; 11(6):783-98. PMID: 23103054.
    Citations: 130     Fields:    Translation:AnimalsCells
  68. Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, Klein OD, Thesleff I, Michon F. Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell. 2012 Aug 14; 23(2):317-28. PMID: 22819339.
    Citations: 112     Fields:    Translation:AnimalsCells
  69. Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H. The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell. 2012 Sep 07; 11(3):319-32. PMID: 22770845.
    Citations: 53     Fields:    Translation:AnimalsCells
  70. Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S. Stem cells assessed. Nat Rev Mol Cell Biol. 2012 06 08; 13(7):471-6. PMID: 22678486.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  71. Stadtfeld M, Apostolou E, Ferrari F, Choi J, Walsh RM, Chen T, Ooi SS, Kim SY, Bestor TH, Shioda T, Park PJ, Hochedlinger K. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet. 2012 Mar 04; 44(4):398-405, S1-2. PMID: 22387999.
    Citations: 142     Fields:    Translation:AnimalsCells
  72. Sarkar A, Hochedlinger K. A gutsy way to grow: intestinal stem cells as nutrient sensors. Cell. 2011 Oct 28; 147(3):487-9. PMID: 22036555.
    Citations: 1     Fields:    
  73. Hochedlinger K. Embryonic stem cells: testing the germ-cell theory. Curr Biol. 2011 Oct 25; 21(20):R850-2. PMID: 22032189.
    Citations: 1     Fields:    Translation:AnimalsCells
  74. Tan KY, Eminli S, Hettmer S, Hochedlinger K, Wagers AJ. Efficient generation of iPS cells from skeletal muscle stem cells. PLoS One. 2011; 6(10):e26406. PMID: 22028872.
    Citations: 23     Fields:    Translation:AnimalsCells
  75. Arnold K, Sarkar A, Yram MA, Polo JM, Bronson R, Sengupta S, Seandel M, Geijsen N, Hochedlinger K. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell. 2011 Oct 04; 9(4):317-29. PMID: 21982232.
    Citations: 338     Fields:    Translation:AnimalsCells
  76. Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular reprogramming. Cell. 2011 Jun 10; 145(6):835-50. PMID: 21663790.
    Citations: 200     Fields:    Translation:HumansAnimalsCells
  77. Apostolou E, Hochedlinger K. Stem cells: iPS cells under attack. Nature. 2011 Jun 08; 474(7350):165-6. PMID: 21654792.
    Citations: 11     Fields:    Translation:AnimalsCells
  78. Wu SM, Hochedlinger K. Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat Cell Biol. 2011 May; 13(5):497-505. PMID: 21540845.
    Citations: 215     Fields:    Translation:HumansAnimalsCells
  79. Ohi Y, Qin H, Hong C, Blouin L, Polo JM, Guo T, Qi Z, Downey SL, Manos PD, Rossi DJ, Yu J, Hebrok M, Hochedlinger K, Costello JF, Song JS, Ramalho-Santos M. Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol. 2011 May; 13(5):541-9. PMID: 21499256.
    Citations: 284     Fields:    Translation:HumansCells
  80. Hochedlinger K. From MYOD1 to iPS cells. Nat Rev Mol Cell Biol. 2010 Dec; 11(12):817. PMID: 21102604.
    Citations: 1     Fields:    
  81. Walsh RM, Hochedlinger K. Modeling Rett syndrome with stem cells. Cell. 2010 Nov 12; 143(4):499-500. PMID: 21074040.
    Citations: 10     Fields:    
  82. Serwold T, Hochedlinger K, Swindle J, Hedgpeth J, Jaenisch R, Weissman IL. T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18939-43. PMID: 20956329.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  83. Stadtfeld M, Hochedlinger K. Induced pluripotency: history, mechanisms, and applications. Genes Dev. 2010 Oct 15; 24(20):2239-63. PMID: 20952534.
    Citations: 322     Fields:    Translation:HumansAnimalsCells
  84. Brady BL, Oropallo MA, Yang-Iott KS, Serwold T, Hochedlinger K, Jaenisch R, Weissman IL, Bassing CH. Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes. J Immunol. 2010 Sep 15; 185(6):3564-73. PMID: 20709953.
    Citations: 12     Fields:    Translation:AnimalsCells
  85. Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, Apostolou E, Stadtfeld M, Li Y, Shioda T, Natesan S, Wagers AJ, Melnick A, Evans T, Hochedlinger K. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol. 2010 Aug; 28(8):848-55. PMID: 20644536.
    Citations: 563     Fields:    Translation:AnimalsCells
  86. Polo JM, Hochedlinger K. When fibroblasts MET iPSCs. Cell Stem Cell. 2010 Jul 02; 7(1):5-6. PMID: 20621040.
    Citations: 34     Fields:    
  87. Buecker C, Chen HH, Polo JM, Daheron L, Bu L, Barakat TS, Okwieka P, Porter A, Gribnau J, Hochedlinger K, Geijsen N. A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells. Cell Stem Cell. 2010 Jun 04; 6(6):535-46. PMID: 20569691.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  88. Hochedlinger K. Your inner healers. Sci Am. 2010 May; 302(5):46-53. PMID: 20443377.
    Citations:    Fields:    Translation:HumansAnimalsCells
  89. Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature. 2010 May 13; 465(7295):175-81. PMID: 20418860.
    Citations: 383     Fields:    Translation:AnimalsCells
  90. Yang-Iott KS, Carpenter AC, Rowh MA, Steinel N, Brady BL, Hochedlinger K, Jaenisch R, Bassing CH. TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexes. J Immunol. 2010 Feb 01; 184(3):1369-78. PMID: 20042591.
    Citations: 11     Fields:    Translation:AnimalsCells
  91. Stadtfeld M, Maherali N, Borkent M, Hochedlinger K. A reprogrammable mouse strain from gene-targeted embryonic stem cells. Nat Methods. 2010 Jan; 7(1):53-5. PMID: 20010832.
    Citations: 102     Fields:    Translation:AnimalsCells
  92. Izpisúa Belmonte JC, Ellis J, Hochedlinger K, Yamanaka S. Induced pluripotent stem cells and reprogramming: seeing the science through the hype. Nat Rev Genet. 2009 12; 10(12):878-83. PMID: 19859062.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  93. Maherali N, Hochedlinger K. Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc. Curr Biol. 2009 Nov 03; 19(20):1718-23. PMID: 19765992.
    Citations: 165     Fields:    Translation:AnimalsCells
  94. Utikal J, Maherali N, Kulalert W, Hochedlinger K. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci. 2009 Oct 01; 122(Pt 19):3502-10. PMID: 19723802.
    Citations: 143     Fields:    Translation:HumansAnimalsCells
  95. Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, Khalil A, Rheinwald JG, Hochedlinger K. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature. 2009 Aug 27; 460(7259):1145-8. PMID: 19668190.
    Citations: 412     Fields:    Translation:HumansAnimalsCells
  96. Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, Hock H, Hochedlinger K. Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet. 2009 Sep; 41(9):968-76. PMID: 19668214.
    Citations: 188     Fields:    Translation:AnimalsCells
  97. Geijsen N, Hochedlinger K. gPS navigates germ cells to pluripotency. Cell Stem Cell. 2009 Jul 02; 5(1):3-4. PMID: 19570505.
    Citations: 4     Fields:    Translation:AnimalsCells
  98. Chen L, Yabuuchi A, Eminli S, Takeuchi A, Lu CW, Hochedlinger K, Daley GQ. Cross-regulation of the Nanog and Cdx2 promoters. Cell Res. 2009 Sep; 19(9):1052-61. PMID: 19564890.
    Citations: 47     Fields:    Translation:AnimalsCells
  99. Stadtfeld M, Hochedlinger K. Without a trace? PiggyBac-ing toward pluripotency. Nat Methods. 2009 May; 6(5):329-30. PMID: 19404251.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  100. Hochedlinger K. Balancing work and life: a conversation with Konrad Hochedlinger. Interview by Majlinda Lako and Susan Daher. Stem Cells. 2009 May; 27(5):991-2. PMID: 19415762.
    Citations: 1     Fields:    Translation:HumansAnimals
  101. Deng J, Shoemaker R, Xie B, Gore A, LeProust EM, Antosiewicz-Bourget J, Egli D, Maherali N, Park IH, Yu J, Daley GQ, Eggan K, Hochedlinger K, Thomson J, Wang W, Gao Y, Zhang K. Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol. 2009 Apr; 27(4):353-60. PMID: 19330000.
    Citations: 231     Fields:    Translation:HumansCells
  102. Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, Mostoslavsky G. Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells. 2009 Mar; 27(3):543-9. PMID: 19096035.
    Citations: 297     Fields:    Translation:AnimalsCells
  103. Hochedlinger K, Plath K. Epigenetic reprogramming and induced pluripotency. Development. 2009 Feb; 136(4):509-23. PMID: 19168672.
    Citations: 228     Fields:    Translation:HumansAnimalsCells
  104. Varas F, Stadtfeld M, de Andres-Aguayo L, Maherali N, di Tullio A, Pantano L, Notredame C, Hochedlinger K, Graf T. Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions. Stem Cells. 2009 Feb; 27(2):300-6. PMID: 19008347.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  105. Foudi A, Hochedlinger K, Van Buren D, Schindler JW, Jaenisch R, Carey V, Hock H. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol. 2009 Jan; 27(1):84-90. PMID: 19060879.
    Citations: 253     Fields:    Translation:HumansAnimalsCells
  106. Maherali N, Hochedlinger K. Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell. 2008 Dec 04; 3(6):595-605. PMID: 19041776.
    Citations: 163     Fields:    Translation:Cells
  107. Maherali N, Hochedlinger K. Induced pluripotency of mouse and human somatic cells. Cold Spring Harb Symp Quant Biol. 2008; 73:157-62. PMID: 19022751.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  108. Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science. 2008 Nov 07; 322(5903):945-9. PMID: 18818365.
    Citations: 600     Fields:    Translation:AnimalsCells
  109. Maherali N, Ahfeldt T, Rigamonti A, Utikal J, Cowan C, Hochedlinger K. A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell. 2008 Sep 11; 3(3):340-5. PMID: 18786420.
    Citations: 221     Fields:    Translation:HumansCells
  110. Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ. Disease-specific induced pluripotent stem cells. Cell. 2008 Sep 05; 134(5):877-86. PMID: 18691744.
    Citations: 957     Fields:    Translation:HumansCells
  111. Eminli S, Utikal J, Arnold K, Jaenisch R, Hochedlinger K. Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells. 2008 Oct; 26(10):2467-74. PMID: 18635867.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  112. Stadtfeld M, Brennand K, Hochedlinger K. Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Curr Biol. 2008 Jun 24; 18(12):890-4. PMID: 18501604.
    Citations: 151     Fields:    Translation:AnimalsCells
  113. Stadtfeld M, Maherali N, Breault DT, Hochedlinger K. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 06; 2(3):230-40. PMID: 18371448.
    Citations: 352     Fields:    Translation:AnimalsCells
  114. Hyun I, Hochedlinger K, Jaenisch R, Yamanaka S. New advances in iPS cell research do not obviate the need for human embryonic stem cells. Cell Stem Cell. 2007 Oct 11; 1(4):367-8. PMID: 18371375.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  115. Lengner CJ, Camargo FD, Hochedlinger K, Welstead GG, Zaidi S, Gokhale S, Scholer HR, Tomilin A, Jaenisch R. Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell. 2007 Oct 11; 1(4):403-15. PMID: 18159219.
    Citations: 178     Fields:    Translation:AnimalsCells
  116. Hochedlinger K. Konrad Hochedlinger: the new kid of nuclear reprogramming. J Cell Biol. 2007 Sep 24; 178(7):1098-9. PMID: 17893238.
    Citations:    Fields:    Translation:HumansAnimals
  117. Serwold T, Hochedlinger K, Inlay MA, Jaenisch R, Weissman IL. Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes. J Immunol. 2007 Jul 15; 179(2):928-38. PMID: 17617584.
    Citations: 28     Fields:    Translation:AnimalsCells
  118. Maherali N, Sridharan R, Xie W, Utikal J, Eminli S, Arnold K, Stadtfeld M, Yachechko R, Tchieu J, Jaenisch R, Plath K, Hochedlinger K. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell. 2007 Jun 07; 1(1):55-70. PMID: 18371336.
    Citations: 676     Fields:    Translation:AnimalsCells
  119. Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature. 2007 Jul 19; 448(7151):318-24. PMID: 17554336.
    Citations: 1006     Fields:    Translation:AnimalsCells
  120. Hochedlinger K, Jaenisch R. On the cloning of animals from terminally differentiated cells. Nat Genet. 2007 Feb; 39(2):136-7; author reply 137-8. PMID: 17262020.
    Citations: 6     Fields:    Translation:AnimalsCells
  121. Hochedlinger K, Jaenisch R. Nuclear reprogramming and pluripotency. Nature. 2006 Jun 29; 441(7097):1061-7. PMID: 16810240.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  122. Brambrink T, Hochedlinger K, Bell G, Jaenisch R. ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):933-8. PMID: 16418286.
    Citations: 65     Fields:    Translation:AnimalsCells
  123. Eminli S, Jaenisch R, Hochedlinger K. Strategies to induce nuclear reprogramming. Ernst Schering Found Symp Proc. 2006; (5):83-98. PMID: 17939296.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  124. Beard C, Hochedlinger K, Plath K, Wutz A, Jaenisch R. Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis. 2006 Jan; 44(1):23-8. PMID: 16400644.
    Citations: 259     Fields:    Translation:AnimalsCells
  125. Hochedlinger K, Yamada Y, Beard C, Jaenisch R. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell. 2005 May 06; 121(3):465-77. PMID: 15882627.
    Citations: 383     Fields:    Translation:AnimalsCells
  126. Koralov SB, Novobrantseva TI, Hochedlinger K, Jaenisch R, Rajewsky K. Direct in vivo VH to JH rearrangement violating the 12/23 rule. J Exp Med. 2005 Feb 07; 201(3):341-8. PMID: 15699070.
    Citations: 19     Fields:    Translation:AnimalsCells
  127. Gribnau J, Luikenhuis S, Hochedlinger K, Monkhorst K, Jaenisch R. X chromosome choice occurs independently of asynchronous replication timing. J Cell Biol. 2005 Jan 31; 168(3):365-73. PMID: 15668296.
    Citations: 26     Fields:    Translation:AnimalsCells
  128. Jaenisch R, Hochedlinger K, Eggan K. Nuclear cloning, epigenetic reprogramming and cellular differentiation. Novartis Found Symp. 2005; 265:107-18; discussion 118-28. PMID: 16050253.
    Citations: 1     Fields:    Translation:AnimalsCells
  129. Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell. 2004 Sep 10; 15(5):713-25. PMID: 15350216.
    Citations: 165     Fields:    Translation:AnimalsCells
  130. Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B, Chin L, Jaenisch R. Nuclear cloning of embryonal carcinoma cells. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):13985-90. PMID: 15306687.
    Citations: 54     Fields:    Translation:AnimalsCells
  131. Hochedlinger K, Blelloch R, Brennan C, Yamada Y, Kim M, Chin L, Jaenisch R. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev. 2004 Aug 01; 18(15):1875-85. PMID: 15289459.
    Citations: 131     Fields:    Translation:AnimalsCells
  132. Jaenisch R, Hochedlinger K, Blelloch R, Yamada Y, Baldwin K, Eggan K. Nuclear cloning, epigenetic reprogramming, and cellular differentiation. Cold Spring Harb Symp Quant Biol. 2004; 69:19-27. PMID: 16117629.
    Citations: 10     Fields:    Translation:AnimalsCells
  133. Hochedlinger K, Rideout WM, Kyba M, Daley GQ, Blelloch R, Jaenisch R. Nuclear transplantation, embryonic stem cells and the potential for cell therapy. Hematol J. 2004; 5 Suppl 3:S114-7. PMID: 15190291.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  134. Hochedlinger K, Jaenisch R. Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. N Engl J Med. 2003 Jul 17; 349(3):275-86. PMID: 12867612.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  135. Gribnau J, Hochedlinger K, Hata K, Li E, Jaenisch R. Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization. Genes Dev. 2003 Mar 15; 17(6):759-73. PMID: 12651894.
    Citations: 39     Fields:    Translation:AnimalsCells
  136. Hochedlinger K, Jaenisch R. Nuclear transplantation: lessons from frogs and mice. Curr Opin Cell Biol. 2002 Dec; 14(6):741-8. PMID: 12473349.
    Citations: 33     Fields:    Translation:AnimalsCells
  137. Humpherys D, Eggan K, Akutsu H, Friedman A, Hochedlinger K, Yanagimachi R, Lander ES, Golub TR, Jaenisch R. Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12889-94. PMID: 12235366.
    Citations: 83     Fields:    Translation:AnimalsCells
  138. Rideout WM, Hochedlinger K, Kyba M, Daley GQ, Jaenisch R. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell. 2002 Apr 05; 109(1):17-27. PMID: 11955443.
    Citations: 118     Fields:    Translation:AnimalsCells
  139. Hochedlinger K, Wagner EF, Sabapathy K. Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis. Oncogene. 2002 Apr 04; 21(15):2441-5. PMID: 11948429.
    Citations: 29     Fields:    Translation:AnimalsCells
  140. Hochedlinger K, Jaenisch R. Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature. 2002 Feb 28; 415(6875):1035-8. PMID: 11875572.
    Citations: 126     Fields:    Translation:AnimalsCells
  141. Jeanisch R, Eggan K, Humpherys D, Rideout W, Hochedlinger K. Nuclear cloning, stem cells, and genomic reprogramming. Cloning Stem Cells. 2002; 4(4):389-96. PMID: 12630413.
    Citations: 12     Fields:    Translation:AnimalsCells
  142. Humpherys D, Eggan K, Akutsu H, Hochedlinger K, Rideout WM, Biniszkiewicz D, Yanagimachi R, Jaenisch R. Epigenetic instability in ES cells and cloned mice. Science. 2001 Jul 06; 293(5527):95-7. PMID: 11441181.
    Citations: 146     Fields:    Translation:AnimalsCells
  143. Eggan K, Akutsu H, Hochedlinger K, Rideout W, Yanagimachi R, Jaenisch R. X-Chromosome inactivation in cloned mouse embryos. Science. 2000 Nov 24; 290(5496):1578-81. PMID: 11090356.
    Citations: 51     Fields:    Translation:AnimalsCells
  144. Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev. 1999 Dec; 89(1-2):115-24. PMID: 10559486.
    Citations: 122     Fields:    Translation:Animals
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Physical Neighbors
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.