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Jian Kong, M.D.


Available: 10/08/18, Expires: 10/08/21

We are seeking students to assist on several NIH-funded clinical research projects conducted by our lab in the Department of Psychiatry, Massachusetts General Hospital at the Charlestown Navy Yard campus. 1. Modulating placebo and nocebo effects using brain stimulation methods in healthy subjects and chronic pain patients. This project aims to investigate the analgesic effects of expectancy and transcranial direct current stimulation (tDCS), as measured by functional magnetic resonance imaging (fMRI). This project is currently ongoing, and students will gain knowledge of brain imaging and brain stimulation methods. 2. Brain pathophysiology of chronic low back pain and modulation effects of acupuncture. This project aims to investigate brain function and structure changes of chronic low back pain patients, as well as the modulation effects of acupuncture and treatment context. Data collection has been completed. The student will be involved in brain functional and structural data analysis and manuscript preparation, which may lead to a co-author or co-first author based on contribution. 3. Brain imaging study of visual guided acupuncture treatment. This project aims to comparatively investigate the analgesic effects of acupuncture and imagery acupuncture with both behavioral and brain imaging tools. Data collection has been completed. The student will be involved in brain functional and structural data analysis and manuscript preparation, which may lead to a co-author or co-first author based on contribution. Other projects: We also have several other brain imaging projects on mind-body interventions, such as Tai Chi (a popular mind-body intervention) treatment of fibromyalgia and auricular vagus nerve stimulation treatment of depression and migraine. The student will be involved in brain functional and structural data analysis their association with clinical outcomes, and manuscript preparation, which may lead to a co-author or co-first author based on contribution.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tu Y, Park J, Ahlfors SP, Khan S, Egorova N, Lang C, Cao J, Kong J. A neural mechanism of direct and observational conditioning for placebo and nocebo responses. Neuroimage. 2019 Jan 01; 184:954-963. PMID: 30296557.
    View in: PubMed
  2. Cao J, Tu Y, Orr SP, Lang C, Park J, Vangel M, Chen L, Gollub R, Kong J. Analgesic Effects Evoked by Real and Imagined Acupuncture: A Neuroimaging Study. Cereb Cortex. 2018 Aug 23. PMID: 30137262.
    View in: PubMed
  3. Kong J, Wolcott E, Wang Z, Jorgenson K, Harvey WF, Tao J, Rones R, Wang C. Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention. Brain Imaging Behav. 2018 May 02. PMID: 29721768.
    View in: PubMed
  4. Curie A, Friocourt G, des Portes V, Roy A, Nazir T, Brun A, Cheylus A, Marcorelles P, Retzepi K, Maleki N, Bussy G, Paulignan Y, Reboul A, Ibarrola D, Kong J, Hadjikhani N, Laquerrière A, Gollub RL. Basal ganglia involvement in ARX patients: The reason for ARX patients very specific grasping? Neuroimage Clin. 2018; 19:454-465. PMID: 29984154.
    View in: PubMed
  5. Kong J, Wang Z, Leiser J, Minicucci D, Edwards R, Kirsch I, Wasan AD, Lang C, Gerber J, Yu S, Napadow V, Kaptchuk TJ, Gollub RL. Enhancing treatment of osteoarthritis knee pain by boosting expectancy: A functional neuroimaging study. Neuroimage Clin. 2018; 18:325-334. PMID: 29868449.
    View in: PubMed
  6. Khan S, Hashmi JA, Mamashli F, Michmizos K, Kitzbichler MG, Bharadwaj H, Bekhti Y, Ganesan S, Garel KA, Whitfield-Gabrieli S, Gollub RL, Kong J, Vaina LM, Rana KD, Stufflebeam SM, Hämäläinen MS, Kenet T. Maturation trajectories of cortical resting-state networks depend on the mediating frequency band. Neuroimage. 2018 Jul 01; 174:57-68. PMID: 29462724.
    View in: PubMed
  7. Kong J, Fang J, Park J, Li S, Rong P. Treating Depression with Transcutaneous Auricular Vagus Nerve Stimulation: State of the Art and Future Perspectives. Front Psychiatry. 2018; 9:20. PMID: 29459836.
    View in: PubMed
  8. Tu Y, Fang J, Cao J, Wang Z, Park J, Jorgenson K, Lang C, Liu J, Zhang G, Zhao Y, Zhu B, Rong P, Kong J. A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder. Brain Stimul. 2018 May - Jun; 11(3):501-508. PMID: 29398576.
    View in: PubMed
  9. Gollub RL, Kirsch I, Maleki N, Wasan AD, Edwards RR, Tu Y, Kaptchuk TJ, Kong J. A Functional Neuroimaging Study of Expectancy Effects on Pain Response in Patients With Knee Osteoarthritis. J Pain. 2018 May; 19(5):515-527. PMID: 29325883.
    View in: PubMed
  10. Wang Z, Fang J, Liu J, Rong P, Jorgenson K, Park J, Lang C, Hong Y, Zhu B, Kong J. Frequency-dependent functional connectivity of the nucleus accumbens during continuous transcutaneous vagus nerve stimulation in major depressive disorder. J Psychiatr Res. 2018 Jul; 102:123-131. PMID: 29674268.
    View in: PubMed
  11. Jung M, Tu Y, Lang CA, Ortiz A, Park J, Jorgenson K, Kong XJ, Kong J. Decreased structural connectivity and resting-state brain activity in the lateral occipital cortex is associated with social communication deficits in boys with autism spectrum disorder. Neuroimage. 2017 Sep 18. PMID: 28927730.
    View in: PubMed
  12. Rodman AM, Deckersbach T, Chou T, Kong J, Gollub RL, Dougherty DD. A Preliminary Study of the Opioid System and Personality Traits Using Positron Emission Tomography. Mol Neuropsychiatry. 2017 Jul; 3(1):12-18. PMID: 28879197.
    View in: PubMed
  13. Song W, Dai M, Xuan L, Cao Z, Zhou S, Lang C, Lv K, Xu M, Kong J. Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell's Palsy. Neural Plast. 2017; 2017:8796239. PMID: 28299208.
    View in: PubMed
  14. Wang Z, Wang X, Liu J, Chen J, Liu X, Nie G, Jorgenson K, Sohn KC, Huang R, Liu M, Liu B, Kong J. Corrigendum to "Acupuncture treatment modulates the corticostriatal reward circuitry in major depressive disorder" [J. Psychiatr. Res. 84 (2017) 18-26]. J Psychiatr Res. 2017 Apr; 87:105. PMID: 28126211.
    View in: PubMed
  15. Jin Y, Kong J. Transcutaneous Vagus Nerve Stimulation: A Promising Method for Treatment of Autism Spectrum Disorders. Front Neurosci. 2016; 10:609. PMID: 28163670.
    View in: PubMed
  16. Song W, Cao Z, Lang C, Dai M, Xuan L, Lv K, Cui F, Jorgenson K, Xu M, Kong J. Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients. Neuroimage Clin. 2017; 14:122-129. PMID: 28180070.
    View in: PubMed
  17. Luchsinger JA, Burgio L, Mittelman M, Dunner I, Levine JA, Kong J, Silver S, Ramirez M, Teresi JA. Northern Manhattan Hispanic Caregiver Intervention Effectiveness Study: protocol of a pragmatic randomised trial comparing the effectiveness of two established interventions for informal caregivers of persons with dementia. BMJ Open. 2016 11 25; 6(11):e014082. PMID: 27888180.
    View in: PubMed
  18. Chen X, Spaeth RB, Freeman SG, Scarborough DM, Hashmi JA, Wey HY, Egorova N, Vangel M, Mao J, Wasan AD, Edwards RR, Gollub RL, Kong J. The Modulation Effect of Longitudinal Acupuncture on Resting State Functional Connectivity in Knee Osteoarthritis Patients. Mol Pain. 2015 01; 11. PMID: 27655921.
    View in: PubMed
  19. Wang Z, Wang X, Liu J, Chen J, Liu X, Nie G, Jorgenson K, Sohn KC, Huang R, Liu M, Liu B, Kong J. Acupuncture treatment modulates the corticostriatal reward circuitry in major depressive disorder. J Psychiatr Res. 2017 01; 84:18-26. PMID: 27693978.
    View in: PubMed
  20. Liu J, Fang J, Wang Z, Rong P, Hong Y, Fan Y, Wang X, Park J, Jin Y, Liu C, Zhu B, Kong J. Transcutaneous vagus nerve stimulation modulates amygdala functional connectivity in patients with depression. J Affect Disord. 2016 11 15; 205:319-326. PMID: 27559632.
    View in: PubMed
  21. Lachs MS, Teresi JA, Ramirez M, van Haitsma K, Silver S, Eimicke JP, Boratgis G, Sukha G, Kong J, Besas AM, Luna MR, Pillemer KA. The Prevalence of Resident-to-Resident Elder Mistreatment in Nursing Homes. Ann Intern Med. 2016 Aug 16; 165(4):229-36. PMID: 27295575.
    View in: PubMed
  22. Miao H, Chen X, Yan Y, He X, Hu S, Kong J, Wu M, Wei Y, Zhou Y, Wang L, Wang K, Qiu B. Functional connectivity change of brain default mode network in breast cancer patients after chemotherapy. Neuroradiology. 2016 Sep; 58(9):921-8. PMID: 27278455.
    View in: PubMed
  23. Curie A, Brun A, Cheylus A, Reboul A, Nazir T, Bussy G, Delange K, Paulignan Y, Mercier S, David A, Marignier S, Merle L, de Fréminville B, Prieur F, Till M, Mortemousque I, Toutain A, Bieth E, Touraine R, Sanlaville D, Chelly J, Kong J, Ott D, Kassai B, Hadjikhani N, Gollub RL, des Portes V. A Novel Analog Reasoning Paradigm: New Insights in Intellectually Disabled Patients. PLoS One. 2016; 11(2):e0149717. PMID: 26918704; PMCID: PMC4771701.
  24. Tao J, Liu J, Egorova N, Chen X, Sun S, Xue X, Huang J, Zheng G, Wang Q, Chen L, Kong J. Increased Hippocampus-Medial Prefrontal Cortex Resting-State Functional Connectivity and Memory Function after Tai Chi Chuan Practice in Elder Adults. Front Aging Neurosci. 2016; 8:25. PMID: 26909038; PMCID: PMC4754402.
  25. Rong P, Liu J, Wang L, Liu R, Fang J, Zhao J, Zhao Y, Wang H, Vangel M, Sun S, Ben H, Park J, Li S, Meng H, Zhu B, Kong J. Effect of transcutaneous auricular vagus nerve stimulation on major depressive disorder: A nonrandomized controlled pilot study. J Affect Disord. 2016 May; 195:172-9. PMID: 26896810; PMCID: PMC4828906 [Available on 05/01/17].
  26. Li Z, Liu M, Lan L, Zeng F, Makris N, Liang Y, Guo T, Wu F, Gao Y, Dong M, Yang J, Li Y, Gong Q, Liang F, Kong J. Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment. Sci Rep. 2016 Feb 03; 6:20298. PMID: 26839078; PMCID: PMC4738255.
  27. Chen S, Zhang W, Wang JM, Duan HT, Kong JH, Wang YX, Dong M, Bi X, Song J. Differentiation of isolated human umbilical cord mesenchymal stem cells into neural stem cells. Int J Ophthalmol. 2016; 9(1):41-7. PMID: 26949608; PMCID: PMC4768521.
  28. Dong S, Kong J, Kong F, Kong J, Gao J, Ji L, Pan B, Chen L, Zheng L, Sun W. Sorafenib suppresses the epithelial-mesenchymal transition of hepatocellular carcinoma cells after insufficient radiofrequency ablation. BMC Cancer. 2015 Nov 30; 15:939. PMID: 26620566; PMCID: PMC4663721.
  29. Egorova N, Park J, Orr SP, Kirsch I, Gollub RL, Kong J. Not seeing or feeling is still believing: conscious and non-conscious pain modulation after direct and observational learning. Sci Rep. 2015 Nov 18; 5:16809. PMID: 26578164; PMCID: PMC4649469.
  30. Chen X, Spaeth RB, Freeman SG, Scarborough DM, Hashmi JA, Wey HY, Egorova N, Vangel M, Mao J, Wasan AD, Edwards RR, Gollub RL, Kong J. The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients. Mol Pain. 2015 Oct 29; 11:67. PMID: 26511911; PMCID: PMC4625557.
  31. Egorova N, Gollub RL, Kong J. Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain. Neuroimage Clin. 2015; 9:430-5. PMID: 26594625; PMCID: PMC4596925.
  32. Tang J, Yao Y, Zhang L, Kong J. Tomographic reconstruction of ionospheric electron density during the storm of 5-6 August 2011 using multi-source data. Sci Rep. 2015 Aug 12; 5:13042. PMID: 26266764; PMCID: PMC4533594.
  33. Yu X, Zhu B, Lin Z, Qiao H, Kong J, Gao X. Acupoint Sensitization, Acupuncture Analgesia, Acupuncture on Visceral Functional Disorders, and Its Mechanism. Evid Based Complement Alternat Med. 2015; 2015:171759. PMID: 26300944; PMCID: PMC4537726.
  34. Egorova N, Yu R, Kaur N, Vangel M, Gollub RL, Dougherty DD, Kong J, Camprodon JA. Neuromodulation of conditioned placebo/nocebo in heat pain: anodal vs cathodal transcranial direct current stimulation to the right dorsolateral prefrontal cortex. Pain. 2015 Jul; 156(7):1342-7. PMID: 25806605; PMCID: PMC4474770.
  35. Schoenthaler A, Luerassi L, Silver S, Odedosu T, Kong J, Ravenell J, Teresi JA, Ogedegbe G. Comparative Effectiveness of a Practice-Based Comprehensive Lifestyle Intervention vs. Single Session Counseling in Hypertensive Blacks. Am J Hypertens. 2016 Feb; 29(2):280-7. PMID: 26135553; PMCID: PMC4751244 [Available on 02/01/17].
  36. Kong JH, Zheng D, Chen S, Duan HT, Wang YX, Dong M, Song J. A comparative study on the transplantation of different concentrations of human umbilical mesenchymal cells into diabetic rats. Int J Ophthalmol. 2015; 8(2):257-62. PMID: 25938037; PMCID: PMC4413587.
  37. Liu CZ, Litscher G, Liang FR, Kong J, Wang LP, Wang L. Deqi sensation in different kinds of acupuncture 2014. Evid Based Complement Alternat Med. 2015; 2015:306138. PMID: 25960749; PMCID: PMC4415449.
  38. Fang J, Rong P, Hong Y, Fan Y, Liu J, Wang H, Zhang G, Chen X, Shi S, Wang L, Liu R, Hwang J, Li Z, Tao J, Wang Y, Zhu B, Kong J. Transcutaneous Vagus Nerve Stimulation Modulates Default Mode Network in Major Depressive Disorder. Biol Psychiatry. 2016 Feb 15; 79(4):266-73. PMID: 25963932.
    View in: PubMed
  39. Freeman S, Yu R, Egorova N, Chen X, Kirsch I, Claggett B, Kaptchuk TJ, Gollub RL, Kong J. Distinct neural representations of placebo and nocebo effects. Neuroimage. 2015 May 15; 112:197-207. PMID: 25776211.
    View in: PubMed
  40. Langevin HM, Schnyer R, MacPherson H, Davis R, Harris RE, Napadow V, Wayne PM, Milley RJ, Lao L, Stener-Victorin E, Kong JT, Hammerschlag R. Manual and electrical needle stimulation in acupuncture research: pitfalls and challenges of heterogeneity. J Altern Complement Med. 2015 Mar; 21(3):113-28. PMID: 25710206; PMCID: PMC4855731.
  41. Lee IS, Wallraven C, Kong J, Chang DS, Lee H, Park HJ, Chae Y. When pain is not only pain: inserting needles into the body evokes distinct reward-related brain responses in the context of a treatment. Physiol Behav. 2015 Mar 01; 140:148-55. PMID: 25528104.
    View in: PubMed
  42. Jensen KB, Kaptchuk TJ, Chen X, Kirsch I, Ingvar M, Gollub RL, Kong J. A Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses. Cereb Cortex. 2015 Oct; 25(10):3903-10. PMID: 25452576; PMCID: PMC4585522.
  43. Bai L, Harris RE, Kong J, Lao L, Napadow V, Zhao B. Neurobiological mechanisms of acupuncture 2014. Evid Based Complement Alternat Med. 2014; 2014:765068. PMID: 25525448; PMCID: PMC4265683.
  44. Dolman AJ, Loggia ML, Edwards RR, Gollub RL, Kong J, Napadow V, Wasan AD. Phenotype matters: the absence of a positive association between cortical thinning and chronic low back pain when controlling for salient clinical variables. Clin J Pain. 2014 Oct; 30(10):839-45. PMID: 24135900; PMCID: PMC4103969.
  45. Chen X, Spaeth RB, Retzepi K, Ott D, Kong J. Acupuncture modulates cortical thickness and functional connectivity in knee osteoarthritis patients. Sci Rep. 2014 Sep 26; 4:6482. PMID: 25258037; PMCID: PMC4175730.
  46. Hsieh C, Kong J, Kirsch I, Edwards RR, Jensen KB, Kaptchuk TJ, Gollub RL. Well-loved music robustly relieves pain: a randomized, controlled trial. PLoS One. 2014; 9(9):e107390. PMID: 25211164; PMCID: PMC4161415.
  47. Yu R, Gollub RL, Spaeth R, Napadow V, Wasan A, Kong J. Disrupted functional connectivity of the periaqueductal gray in chronic low back pain. Neuroimage Clin. 2014; 6:100-8. PMID: 25379421; PMCID: PMC4215524.
  48. Wey HY, Catana C, Hooker JM, Dougherty DD, Knudsen GM, Wang DJ, Chonde DB, Rosen BR, Gollub RL, Kong J. Simultaneous fMRI-PET of the opioidergic pain system in human brain. Neuroimage. 2014 Nov 15; 102 Pt 2:275-82. PMID: 25107855; PMCID: PMC4348014.
  49. Takakura N, Takayama M, Kawase A, Kaptchuk TJ, Kong J, Yajima H. Design of a randomised acupuncture trial on functional neck/shoulder stiffness with two placebo controls. BMC Complement Altern Med. 2014 Jul 16; 14:246. PMID: 25027157; PMCID: PMC4223566.
  50. Huang F, Dong J, Kong J, Wang H, Meng H, Spaeth RB, Camhi S, Liao X, Li X, Zhai X, Li S, Zhu B, Rong P. Effect of transcutaneous auricular vagus nerve stimulation on impaired glucose tolerance: a pilot randomized study. BMC Complement Altern Med. 2014 Jun 26; 14:203. PMID: 24968966; PMCID: PMC4227038.
  51. Zhu D, Chang J, Freeman S, Tan Z, Xiao J, Gao Y, Kong J. Changes of functional connectivity in the left frontoparietal network following aphasic stroke. Front Behav Neurosci. 2014; 8:167. PMID: 24860452; PMCID: PMC4026698.
  52. Hashmi JA, Kong J, Spaeth R, Khan S, Kaptchuk TJ, Gollub RL. Functional network architecture predicts psychologically mediated analgesia related to treatment in chronic knee pain patients. J Neurosci. 2014 Mar 12; 34(11):3924-36. PMID: 24623770.
    View in: PubMed
  53. Kirsch I, Kong J, Sadler P, Spaeth R, Cook A, Kaptchuk T, Gollub R. Expectancy and Conditioning in Placebo Analgesia: Separate or Connected Processes? Psychol Conscious (Wash D C). 2014 Mar; 1(1):51-59. PMID: 25093194.
    View in: PubMed
  54. Yu R, Gollub RL, Vangel M, Kaptchuk T, Smoller JW, Kong J. Placebo analgesia and reward processing: integrating genetics, personality, and intrinsic brain activity. Hum Brain Mapp. 2014 Sep; 35(9):4583-93. PMID: 24578196; PMCID: PMC4107077.
  55. Ellis JM, Teresi JA, Ramirez M, Silver S, Boratgis G, Kong J, Eimicke JP, Sukha G, Lachs MS, Pillemer KA. Managing resident-to-resident elder mistreatment in nursing homes: the SEARCH approach. J Contin Educ Nurs. 2014 Mar; 45(3):112-21; quiz 122-3. PMID: 24548656; PMCID: PMC4178932.
  56. Curie A, Nazir T, Brun A, Paulignan Y, Reboul A, Delange K, Cheylus A, Bertrand S, Rochefort F, Bussy G, Marignier S, Lacombe D, Chiron C, Cossée M, Leheup B, Philippe C, Laugel V, De Saint Martin A, Sacco S, Poirier K, Bienvenu T, Souville I, Gilbert-Dussardier B, Bieth E, Kauffmann D, Briot P, de Fréminville B, Prieur F, Till M, Rooryck-Thambo C, Mortemousque I, Bobillier-Chaumont I, Toutain A, Touraine R, Sanlaville D, Chelly J, Freeman S, Kong J, Hadjikhani N, Gollub RL, Roy A, des Portes V. The c.429_452 duplication of the ARX gene: a unique developmental-model of limb kinetic apraxia. Orphanet J Rare Dis. 2014 Feb 14; 9:25. PMID: 24528893; PMCID: PMC4016261.
  57. Liu CZ, Litscher G, Liang FR, Kong J, Wang LP, Wang L. Deqi sensation in different kinds of acupuncture. Evid Based Complement Alternat Med. 2014; 2014:121573. PMID: 24665333; PMCID: PMC3934390.
  58. Palmas W, Findley SE, Mejia M, Batista M, Teresi J, Kong J, Silver S, Fleck EM, Luchsinger JA, Carrasquillo O. Results of the northern Manhattan diabetes community outreach project: a randomized trial studying a community health worker intervention to improve diabetes care in Hispanic adults. Diabetes Care. 2014 Apr; 37(4):963-9. PMID: 24496805; PMCID: PMC3964489.
  59. Kong J, Benedetti F. Placebo and nocebo effects: an introduction to psychological and biological mechanisms. Handb Exp Pharmacol. 2014; 225:3-15. PMID: 25304523.
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  60. Jensen KB, Srinivasan P, Spaeth R, Tan Y, Kosek E, Petzke F, Carville S, Fransson P, Marcus H, Williams SC, Choy E, Vitton O, Gracely R, Ingvar M, Kong J. Overlapping structural and functional brain changes in patients with long-term exposure to fibromyalgia pain. Arthritis Rheum. 2013 Dec; 65(12):3293-303. PMID: 23982850; PMCID: PMC3984030.
  61. Bai L, Harris RE, Kong J, Lao L, Napadow V, Zhao B. Neurobiological mechanisms of acupuncture. Evid Based Complement Alternat Med. 2013; 2013:652457. PMID: 24369480; PMCID: PMC3863533.
  62. Wells RE, Yeh GY, Kerr CE, Wolkin J, Davis RB, Tan Y, Spaeth R, Wall RB, Walsh J, Kaptchuk TJ, Press D, Phillips RS, Kong J. Meditation's impact on default mode network and hippocampus in mild cognitive impairment: a pilot study. Neurosci Lett. 2013 Nov 27; 556:15-9. PMID: 24120430; PMCID: PMC4022038.
  63. Sabatier I, Chabrier S, Brun A, Hees L, Cheylus A, Gollub R, Hadjikhani N, Kong J, des Portes V, Floret D, Curie A. Stroke by carotid artery complete occlusion in Kawasaki disease: case report and review of literature. Pediatr Neurol. 2013 Dec; 49(6):469-73. PMID: 24095647.
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  64. Kong J, Spaeth RB, Wey HY, Cheetham A, Cook AH, Jensen K, Tan Y, Liu H, Wang D, Loggia ML, Napadow V, Smoller JW, Wasan AD, Gollub RL. S1 is associated with chronic low back pain: a functional and structural MRI study. Mol Pain. 2013 Aug 21; 9:43. PMID: 23965184.
    View in: PubMed
  65. Kong J, Spaeth R, Cook A, Kirsch I, Claggett B, Vangel M, Gollub RL, Smoller JW, Kaptchuk TJ. Are all placebo effects equal? Placebo pills, sham acupuncture, cue conditioning and their association. PLoS One. 2013; 8(7):e67485. PMID: 23935833; PMCID: PMC3729687.
  66. Wang X, Fang J, Zhao Q, Fan Y, Liu J, Hong Y, Wang H, Ma Y, Xu C, Shi S, Kong J, Rong P. Deqi sensations of transcutaneous electrical nerve stimulation on auricular points. Evid Based Complement Alternat Med. 2013; 2013:371543. PMID: 23935663; PMCID: PMC3722844.
  67. Spaeth RB, Camhi S, Hashmi JA, Vangel M, Wasan AD, Edwards RR, Gollub RL, Kong J. A longitudinal study of the reliability of acupuncture deqi sensations in knee osteoarthritis. Evid Based Complement Alternat Med. 2013; 2013:204259. PMID: 23935656; PMCID: PMC3713327.
  68. Zhu D, Gao Y, Chang J, Kong J. Placebo acupuncture devices: considerations for acupuncture research. Evid Based Complement Alternat Med. 2013; 2013:628907. PMID: 23840261; PMCID: PMC3690239.
  69. Wells RE, Kerr CE, Wolkin J, Dossett M, Davis RB, Walsh J, Wall RB, Kong J, Kaptchuk T, Press D, Phillips RS, Yeh G. Meditation for adults with mild cognitive impairment: a pilot randomized trial. J Am Geriatr Soc. 2013 Apr; 61(4):642-5. PMID: 23581918; PMCID: PMC3666869.
  70. Shea S, Kothari D, Teresi JA, Kong J, Eimicke JP, Lantigua RA, Palmas W, Weinstock RS. Social impact analysis of the effects of a telemedicine intervention to improve diabetes outcomes in an ethnically diverse, medically underserved population: findings from the IDEATel Study. Am J Public Health. 2013 Oct; 103(10):1888-94. PMID: 23488491; PMCID: PMC3780722.
  71. Ogedegbe G, Fernandez S, Fournier L, Silver SA, Kong J, Gallagher S, de la Calle F, Plumhoff J, Sethi S, Choudhury E, Teresi JA. The Counseling Older Adults to Control Hypertension (COACH) trial: design and methodology of a group-based lifestyle intervention for hypertensive minority older adults. Contemp Clin Trials. 2013 May; 35(1):70-9. PMID: 23462343; PMCID: PMC3805359.
  72. Chae Y, Chang DS, Lee SH, Jung WM, Lee IS, Jackson S, Kong J, Lee H, Park HJ, Lee H, Wallraven C. Inserting needles into the body: a meta-analysis of brain activity associated with acupuncture needle stimulation. J Pain. 2013 Mar; 14(3):215-22. PMID: 23395475.
    View in: PubMed
  73. Kong J, Jensen K, Loiotile R, Cheetham A, Wey HY, Tan Y, Rosen B, Smoller JW, Kaptchuk TJ, Gollub RL. Functional connectivity of the frontoparietal network predicts cognitive modulation of pain. Pain. 2013 Mar; 154(3):459-67. PMID: 23352757; PMCID: PMC3725961.
  74. Rong PJ, Fang JL, Wang LP, Meng H, Liu J, Ma YG, Ben H, Li L, Liu RP, Huang ZX, Zhao YF, Li X, Zhu B, Kong J. Transcutaneous vagus nerve stimulation for the treatment of depression: a study protocol for a double blinded randomized clinical trial. BMC Complement Altern Med. 2012 Dec 14; 12:255. PMID: 23241431; PMCID: PMC3537743.
  75. Teresi JA, Ramirez M, Ellis J, Silver S, Boratgis G, Kong J, Eimicke JP, Pillemer K, Lachs MS. A staff intervention targeting resident-to-resident elder mistreatment (R-REM) in long-term care increased staff knowledge, recognition and reporting: results from a cluster randomized trial. Int J Nurs Stud. 2013 May; 50(5):644-56. PMID: 23159018; PMCID: PMC3677710.
  76. Loggia ML, Kim J, Gollub RL, Vangel MG, Kirsch I, Kong J, Wasan AD, Napadow V. Default mode network connectivity encodes clinical pain: an arterial spin labeling study. Pain. 2013 Jan; 154(1):24-33. PMID: 23111164; PMCID: PMC3534957.
  77. Luchsinger J, Mittelman M, Mejia M, Silver S, Lucero RJ, Ramirez M, Kong J, Teresi JA. The Northern Manhattan Caregiver Intervention Project: a randomised trial testing the effectiveness of a dementia caregiver intervention in Hispanics in New York City. BMJ Open. 2012; 2(5). PMID: 22983877; PMCID: PMC3467593.
  78. Jensen KB, Kaptchuk TJ, Kirsch I, Raicek J, Lindstrom KM, Berna C, Gollub RL, Ingvar M, Kong J. Nonconscious activation of placebo and nocebo pain responses. Proc Natl Acad Sci U S A. 2012 Sep 25; 109(39):15959-64. PMID: 23019380; PMCID: PMC3465419.
  79. Xing J, Kong J, Lu J, Li J. Angiotensin-(1-7) inhibits neuronal activity of dorsolateral periaqueductal gray via a nitric oxide pathway. Neurosci Lett. 2012 Aug 01; 522(2):156-61. PMID: 22728059; PMCID: PMC3401242.
  80. Kong J, Kong J, Pan B, Ke S, Dong S, Li X, Zhou A, Zheng L, Sun WB. Insufficient radiofrequency ablation promotes angiogenesis of residual hepatocellular carcinoma via HIF-1a/VEGFA. PLoS One. 2012; 7(5):e37266. PMID: 22615958; PMCID: PMC3352883.
  81. Jensen KB, Loitoile R, Kosek E, Petzke F, Carville S, Fransson P, Marcus H, Williams SC, Choy E, Mainguy Y, Vitton O, Gracely RH, Gollub R, Ingvar M, Kong J. Patients with fibromyalgia display less functional connectivity in the brain's pain inhibitory network. Mol Pain. 2012 Apr 26; 8:32. PMID: 22537768; PMCID: PMC3404927.
  82. Palmas W, Teresi JA, Findley S, Mejia M, Batista M, Kong J, Silver S, Luchsinger JA, Carrasquillo O. Protocol for the Northern Manhattan Diabetes Community Outreach Project. A randomised trial of a community health worker intervention to improve diabetes care in Hispanic adults. BMJ Open. 2012; 2(2):e001051. PMID: 22454189; PMCID: PMC3330252.
  83. Schoenthaler A, Luerassi L, Teresi JA, Silver S, Kong J, Odedosu T, Trilling S, Errico A, Uvwo O, Sebek K, Adekoya A, Ogedegbe G. A practice-based trial of blood pressure control in African Americans (TLC-Clinic): study protocol for a randomized controlled trial. Trials. 2011 Dec 22; 12:265. PMID: 22192273; PMCID: PMC3264527.
  84. Linnman C, Beucke JC, Jensen KB, Gollub RL, Kong J. Sex similarities and differences in pain-related periaqueductal gray connectivity. Pain. 2012 Feb; 153(2):444-54. PMID: 22154332; PMCID: PMC3558685.
  85. Loggia ML, Jensen K, Gollub RL, Wasan AD, Edwards RR, Kong J. The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli. PLoS One. 2011; 6(11):e27764. PMID: 22132136.
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  86. Wasan AD, Loggia ML, Chen LQ, Napadow V, Kong J, Gollub RL. Neural correlates of chronic low back pain measured by arterial spin labeling. Anesthesiology. 2011 Aug; 115(2):364-74. PMID: 21720241; PMCID: PMC3286828.
  87. Teresi JA, Ramirez M, Remler D, Ellis J, Boratgis G, Silver S, Lindsey M, Kong J, Eimicke JP, Dichter E. Comparative effectiveness of implementing evidence-based education and best practices in nursing homes: effects on falls, quality-of-life and societal costs. Int J Nurs Stud. 2013 Apr; 50(4):448-63. PMID: 21807366.
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  88. Gollub RL, Kong J. For placebo effects in medicine, seeing is believing. Sci Transl Med. 2011 Feb 16; 3(70):70ps5. PMID: 21325616.
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  89. Zyloney CE, Jensen K, Polich G, Loiotile RE, Cheetham A, LaViolette PS, Tu P, Kaptchuk TJ, Gollub RL, Kong J. Imaging the functional connectivity of the Periaqueductal Gray during genuine and sham electroacupuncture treatment. Mol Pain. 2010 Nov 16; 6:80. PMID: 21080967; PMCID: PMC2993660.
  90. Nan-Kai W, Tosi J, Kasanuki JM, Chou CL, Kong J, Parmalee N, Wert KJ, Allikmets R, Lai CC, Chien CL, Nagasaki T, Lin CS, Tsang SH. Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for Retinitis Pigmentosa: Transplantation 2010 April 27;89 (8): 911-919. Ann Neurosci. 2010 Oct; 17(4):185-6. PMID: 25205903; PMCID: PMC4117017.
  91. Qiu WQ, Claunch J, Kong J, Nixon EE, Fang J, Li M, Vangel M, Hui KK. The effects of acupuncture on the brain networks for emotion and cognition: an observation of gender differences. Brain Res. 2010 Nov 29; 1362:56-67. PMID: 20851113.
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  92. Zhang L, Zhong G, Wu Y, Vangel MG, Jiang B, Kong J. Using Granger-Geweke causality model to evaluate the effective connectivity of primary motor cortex (M1), supplementary motor area (SMA) and cerebellum. J Biomed Sci Eng. 2010 Sep 01; 3:848-860. PMID: 21113332.
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  93. Kong J, Tu PC, Zyloney C, Su TP. Intrinsic functional connectivity of the periaqueductal gray, a resting fMRI study. Behav Brain Res. 2010 Aug 25; 211(2):215-9. PMID: 20347878; PMCID: PMC2862838.
  94. Izquierdo R, Lagua CT, Meyer S, Ploutz-Snyder RJ, Palmas W, Eimicke JP, Kong J, Teresi JA, Shea S, Weinstock RS. Telemedicine intervention effects on waist circumference and body mass index in the IDEATel project. Diabetes Technol Ther. 2010 Mar; 12(3):213-20. PMID: 20151772.
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  95. Wasan AD, Kong J, Pham LD, Kaptchuk TJ, Edwards R, Gollub RL. The impact of placebo, psychopathology, and expectations on the response to acupuncture needling in patients with chronic low back pain. J Pain. 2010 Jun; 11(6):555-63. PMID: 20075014; PMCID: PMC2879448.
  96. Kong J, Loggia ML, Zyloney C, Tu P, Laviolette P, Gollub RL. Exploring the brain in pain: activations, deactivations and their relation. Pain. 2010 Feb; 148(2):257-67. PMID: 20005043; PMCID: PMC2815185.
  97. Teruya SL, Gil HR, Teresi JA, Kong J, Eimicke J, Helmke S, Maurer MS. Facilitating clinical trials of anemia in older adults: a point-of-care system to measure hemoglobin in the home and its agreement with a hospital core laboratory. J Am Geriatr Soc. 2009 Dec; 57(12):2362-4. PMID: 20169635; PMCID: PMC4936478.
  98. Kong J, Kaptchuk TJ, Polich G, Kirsch I, Vangel M, Zyloney C, Rosen B, Gollub RL. An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment. Neuroimage. 2009 Sep; 47(3):1066-76. PMID: 19501656; PMCID: PMC2742363.
  99. Fang J, Jin Z, Wang Y, Li K, Kong J, Nixon EE, Zeng Y, Ren Y, Tong H, Wang Y, Wang P, Hui KK. The salient characteristics of the central effects of acupuncture needling: limbic-paralimbic-neocortical network modulation. Hum Brain Mapp. 2009 Apr; 30(4):1196-206. PMID: 18571795.
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  100. Kong J, Kaptchuk TJ, Webb JM, Kong JT, Sasaki Y, Polich GR, Vangel MG, Kwong K, Rosen B, Gollub RL. Functional neuroanatomical investigation of vision-related acupuncture point specificity--a multisession fMRI study. Hum Brain Mapp. 2009 Jan; 30(1):38-46. PMID: 17990299; PMCID: PMC4009985.
  101. Kong J, Kaptchuk TJ, Polich G, Kirsch I, Vangel M, Zyloney C, Rosen B, Gollub R. Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia. Neuroimage. 2009 Apr 15; 45(3):940-9. PMID: 19159691; PMCID: PMC2737445.
  102. Kong J, Gollub RL, Polich G, Kirsch I, Laviolette P, Vangel M, Rosen B, Kaptchuk TJ. A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect. J Neurosci. 2008 Dec 03; 28(49):13354-62. PMID: 19052227; PMCID: PMC2649754.
  103. Davis RJ, Tosi J, Janisch KM, Kasanuki JM, Wang NK, Kong J, Tsui I, Cilluffo M, Woodruff ML, Fain GL, Lin CS, Tsang SH. Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q). Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):5067-76. PMID: 18658088; PMCID: PMC2715364.
  104. Dougherty DD, Kong J, Webb M, Bonab AA, Fischman AJ, Gollub RL. A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia. Behav Brain Res. 2008 Nov 03; 193(1):63-8. PMID: 18562019; PMCID: PMC2538486.
  105. Wang J, Jiang Y, Wang Y, Tang Y, Teng G, Fawcett JP, Kong J, Gu J. A rapid and sensitive LC-MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies. J Pharm Biomed Anal. 2008 Aug 05; 47(4-5):985-9. PMID: 18499386.
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  106. Huang T, Kong J, Huang X, Xu YH. [Some misunderstandings of deqi phenomenon: from historic review to experimental study]. Zhongguo Zhen Jiu. 2008 Feb; 28(2):105-9. PMID: 18405153.
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  107. Kong J, Gollub R, Huang T, Polich G, Napadow V, Hui K, Vangel M, Rosen B, Kaptchuk TJ. Acupuncture de qi, from qualitative history to quantitative measurement. J Altern Complement Med. 2007 Dec; 13(10):1059-70. PMID: 18166116.
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  108. McManus CA, Schnyer RN, Kong J, Nguyen LT, Hyun Nam B, Goldman R, Stason WB, Kaptchuk TJ. Sham acupuncture devices--practical advice for researchers. Acupunct Med. 2007 Jun; 25(1-2):36-40. PMID: 17641566.
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  109. Kong J, Kaptchuk TJ, Polich G, Kirsch I, Gollub RL. Placebo analgesia: findings from brain imaging studies and emerging hypotheses. Rev Neurosci. 2007; 18(3-4):173-90. PMID: 18019605.
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  110. Kong J, Gollub RL, Webb JM, Kong JT, Vangel MG, Kwong K. Test-retest study of fMRI signal change evoked by electroacupuncture stimulation. Neuroimage. 2007 Feb 01; 34(3):1171-81. PMID: 17157035; PMCID: PMC1994822.
  111. Kong J, White NS, Kwong KK, Vangel MG, Rosman IS, Gracely RH, Gollub RL. Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity. Hum Brain Mapp. 2006 Sep; 27(9):715-21. PMID: 16342273.
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  112. Kong J, Gollub RL, Rosman IS, Webb JM, Vangel MG, Kirsch I, Kaptchuk TJ. Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J Neurosci. 2006 Jan 11; 26(2):381-8. PMID: 16407533.
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  113. Kong J, Fufa DT, Gerber AJ, Rosman IS, Vangel MG, Gracely RH, Gollub RL. Psychophysical outcomes from a randomized pilot study of manual, electro, and sham acupuncture treatment on experimentally induced thermal pain. J Pain. 2005 Jan; 6(1):55-64. PMID: 15629419.
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  114. Kong J, Wang C, Kwong K, Vangel M, Chua E, Gollub R. The neural substrate of arithmetic operations and procedure complexity. Brain Res Cogn Brain Res. 2005 Mar; 22(3):397-405. PMID: 15722210.
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  115. Doi K, Kong J, Hargitai J, Goff SP, Gouras P. Transient immunosuppression stops rejection of virus-transduced enhanced green fluorescent protein in rabbit retina. J Virol. 2004 Oct; 78(20):11327-33. PMID: 15452253; PMCID: PMC521797.
  116. Kong J, Ma L, Gollub RL, Wei J, Yang X, Li D, Weng X, Jia F, Wang C, Li F, Li R, Zhuang D. A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods. J Altern Complement Med. 2002 Aug; 8(4):411-9. PMID: 12230901.
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  117. Zhao ZG, Ran YL, Zheng R, Kong J, Chen SZ, Yu L, Yang ZH. [Radioimmunodetection of 188Re-labeled anti-carcinoembryonic antigen chimeric antibody in nude mice bearing human colon carcinoma]. Ai Zheng. 2002 May; 21(5):460-3. PMID: 12452032.
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  118. Park JG, Lee MJ, Kong JY, Jung MH. Synthesis of 5-(4-alkoxy-[1,2,5]thiadiazol-3-yl)-3-methyl-1,2,3,4-tetrahydropyrimidi ne oxalate salts and their evaluation as muscarinic receptor agonists. Arch Pharm (Weinheim). 2000 May; 333(5):113-7. PMID: 10863794.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.