Harvard Catalyst Profiles

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Stephen John Haggarty, Ph.D.

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Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01MH134923 (KARMACHARYA, RAKESH) Jul 8, 2024 - Feb 28, 2029
    NIH
    Targeting Arc to Improve Cognitive Deficits in Psychotic Disorders
    Role: Co-Principal Investigator
  2. R01NS109540 (RAMESH, VIJAYA) Jun 15, 2019 - May 30, 2025
    NIH
    Tuberous Sclerosis Complex Patients iPSC-derived NPCs and NCCs as Human Model Systems to Identify Novel Targets
    Role: Co-Principal Investigator
  3. R21NS109755 (WHEELER, VANESSA C) Feb 15, 2019 - Jan 31, 2021
    NIH
    Modifiers of C9orf72 repeat dynamics
    Role: Co-Principal Investigator
  4. R01NS108115 (HAGGARTY, STEPHEN J;HERZ, JOACHIM J) Sep 30, 2018 - Jul 31, 2023
    NIH
    Validation of Modulators of PGRN as Novel Therapeutics for Frontotemporal Dementi
    Role: Co-Principal Investigator
  5. R01NS099250 (HOOKER, JACOB M.) Jul 1, 2017 - Apr 30, 2022
    NIH
    Epigenetic Radiotracers for PET Imaging: Isoform-SelectiveHDAC Probes
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 171 total Publications Show all
  1. Sandhof CA, Murray HFB, Silva MC, Haggarty SJ. Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond. Neurotherapeutics. 2024 Dec 04; e00499. PMID: 39638711.
    Citations:
    Fields: NeuNeurology
  2. Luo X, Ding Y, Cao Y, Liu Z, Zhang W, Zeng S, Cheng SH, Li H, Haggarty SJ, Wang X, Zhang J, Shi P. Few-shot meta-learning applied to whole brain activity maps improves systems neuropharmacology and drug discovery. iScience. 2024 Oct 18; 27(10):110875. PMID: 39319265; PMCID: PMC11419810.
    Citations: 1
  3. Tesla R, Guhl C, Werthmann GC, Dixon D, Cenik B, Addepalli Y, Liang J, Fass DM, Rosenthal Z, Haggarty SJ, Williams NS, Posner BA, Ready JM, Herz J. Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency. Nat Commun. 2024 Jul 20; 15(1):6125. PMID: 39033178; PMCID: PMC11271458.
    Citations:
    Fields: BioBiologySciScienceTranslation:HumansAnimalsCells
  4. Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, van Rooij JG, Mol MO, Hsiung GR, Graff C, Öijerstedt L, Neumann M, Asmann Y, McDonnell SK, Baheti S, Josephs KA, Whitwell JL, Bieniek KF, Forsberg L, Heuer H, Lago AL, Geier EG, Yokoyama JS, Oddi AP, Flanagan M, Mao Q, Hodges JR, Kwok JB, Domoto-Reilly K, Synofzik M, Wilke C, Onyike C, Dickerson BC, Evers BM, Dugger BN, Munoz DG, Keith J, Zinman L, Rogaeva E, Suh E, Gefen T, Geula C, Weintraub S, Diehl-Schmid J, Farlow MR, Edbauer D, Woodruff BK, Caselli RJ, Donker Kaat LL, Huey ED, Reiman EM, Mead S, King A, Roeber S, Nana AL, Ertekin-Taner N, Knopman DS, Petersen RC, Petrucelli L, Uitti RJ, Wszolek ZK, Ramos EM, Grinberg LT, Gorno Tempini ML, Rosen HJ, Spina S, Piguet O, Grossman M, Trojanowski JQ, Keene DC, Lee-Way J, Prudlo J, Geschwind DH, Rissman RA, Cruchaga C, Ghetti B, Halliday GM, Beach TG, Serrano GE, Arzberger T, Herms J, Boxer AL, Honig LS, Vonsattel JP, Lopez OL, Kofler J, White CL, Gearing M, Glass J, Rohrer JD, Irwin DJ, Lee EB, Van Deerlin V, Castellani R, Mesulam MM, Tartaglia MC, Finger EC, Troakes C, Al-Sarraj S, Miller BL, Seelaar H, Graff-Radford NR, Boeve BF, Mackenzie IR, van Swieten JC, Seeley WW, Sleegers K, Dickson DW, Biernacka JM, Rademakers R. Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing. medRxiv. 2024 Jun 25. PMID: 38978643; PMCID: PMC11230325.
    Citations:
  5. Potter SC, Gibbs BE, Hammel FA, Joiner CM, Paulo JA, Janetzko J, Levine ZG, Fei GQ, Haggarty SJ, Walker S. Dissecting OGT's TPR domain to identify determinants of cellular function. Proc Natl Acad Sci U S A. 2024 May 28; 121(22):e2401729121. PMID: 38768345; PMCID: PMC11145291.
    Citations: 2
    Fields: SciScienceTranslation:HumansAnimalsCells
  6. Rosenthal ZC, Fass DM, Payne NC, She A, Patnaik D, Hennig KM, Tesla R, Werthmann GC, Guhl C, Reis SA, Wang X, Chen Y, Placzek M, Williams NS, Hooker J, Herz J, Mazitschek R, Haggarty SJ. Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia. Sci Rep. 2024 04 20; 14(1):9064. PMID: 38643236; PMCID: PMC11032351.
    Citations:
    Fields: SciScienceTranslation:Humans
  7. Lam M, Kuo SY, Reis S, Gestwicki JE, Silva MC, Haggarty SJ. Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy. bioRxiv. 2023 Dec 12. PMID: 38168389; PMCID: PMC10759997.
    Citations:
  8. Nguyen LD, Wei Z, Silva MC, Barberán-Soler S, Zhang J, Rabinovsky R, Muratore CR, Stricker JMS, Hortman C, Young-Pearse TL, Haggarty SJ, Krichevsky AM. Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing. Nat Commun. 2023 Nov 21; 14(1):7575. PMID: 37989753; PMCID: PMC10663445.
    Citations: 7
    Fields: BioBiologySciScienceTranslation:HumansCells
  9. Bertucci T, Bowles KR, Lotz S, Qi L, Stevens K, Goderie SK, Borden S, Oja LM, Lane K, Lotz R, Lotz H, Chowdhury R, Joy S, Arduini BL, Butler DC, Miller M, Baron H, Sandhof CA, Silva MC, Haggarty SJ, Karch CM, Geschwind DH, Goate AM, Temple S. Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations. bioRxiv. 2023 Jul 11. PMID: 37503195; PMCID: PMC10369860.
    Citations:
  10. Hewitt T, Alural B, Tilak M, Wang J, Becke N, Chartley E, Perreault M, Haggarty SJ, Sheridan SD, Perlis RH, Jones N, Mellios N, Lalonde J. Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation. Mol Psychiatry. 2023 Dec; 28(12):5237-5250. PMID: 37402854; PMCID: PMC11041787.
    Citations: 3
    Fields: MolMolecular BiologyPsyPsychiatryTranslation:HumansCells
  11. Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy. Sci Transl Med. 2023 04 12; 15(691):eabq2915. PMID: 37043557.
    Citations: 5
    Fields: MedMedicine (General)SciScienceTranslation:HumansAnimalsCells
  12. Pao PC, Seo J, Lee A, Kritskiy O, Patnaik D, Penney J, Raju RM, Geigenmuller U, Silva MC, Lucente DE, Gusella JF, Dickerson BC, Loon A, Yu MX, Bula M, Yu M, Haggarty SJ, Tsai LH. A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. Proc Natl Acad Sci U S A. 2023 04 18; 120(16):e2217864120. PMID: 37043533; PMCID: PMC10120002.
    Citations: 7
    Fields: SciScienceTranslation:HumansAnimalsCells
  13. Krichevsky A, Nguyen L, Wei Z, Silva M, Barberán-Soler S, Rabinovsky R, Muratore C, Stricker J, Hortman C, Young-Pearse T, Haggarty S. Small Molecule Regulators of microRNAs Identified by High-Throughput Screen Coupled with High-Throughput Sequencing. Res Sq. 2023 Mar 14. PMID: 36993255; PMCID: PMC10055534.
    Citations:
  14. Kumar A, Aglyamova G, Yim YY, Bailey AO, Lynch HM, Powell RT, Nguyen ND, Rosenthal Z, Zhao WN, Li Y, Chen J, Fan S, Lee H, Russell WK, Stephan C, Robison AJ, Haggarty SJ, Nestler EJ, Zhou J, Machius M, Rudenko G. Chemically targeting the redox switch in AP1 transcription factor ?FOSB. Nucleic Acids Res. 2022 09 09; 50(16):9548-9567. PMID: 36039764; PMCID: PMC9458432.
    Citations: 1
    Fields: BioBiochemistryTranslation:Cells
  15. Fass DM, Lewis MC, Ahmad R, Szucs MJ, Zhang Q, Fleishman M, Wang D, Kim MJ, Biag J, Carr SA, Scolnick EM, Premont RT, Haggarty SJ. Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility. Mol Psychiatry. 2022 08; 27(8):3272-3285. PMID: 35505090; PMCID: PMC9630168.
    Citations: 6
    Fields: MolMolecular BiologyPsyPsychiatryTranslation:AnimalsCells
  16. Silva MC, Nandi G, Donovan KA, Cai Q, Berry BC, Nowak RP, Fischer ES, Gray NS, Ferguson FM, Haggarty SJ. Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy. Front Cell Neurosci. 2022; 16:801179. PMID: 35317195; PMCID: PMC8934437.
    Citations: 9
  17. Hafez AK, Zimmerman AJ, Papageorgiou G, Chandrasekaran J, Amoah SK, Lin R, Lozano E, Pierotti C, Dell'Orco M, Hartley BJ, Alural B, Lalonde J, Esposito JM, Berretta S, Squassina A, Chillotti C, Voloudakis G, Shao Z, Fullard JF, Brennand KJ, Turecki G, Roussos P, Perlis RH, Haggarty SJ, Perrone-Bizzozero N, Brigman JL, Mellios N. A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning. Cell Rep. 2022 01 18; 38(3):110282. PMID: 35045295; PMCID: PMC8809079.
    Citations: 16
    Fields: CelCell BiologyMolMolecular BiologyTranslation:HumansAnimals
  18. Silva MC, Nandi G, Haggarty SJ. Differentiation of Human Induced Pluripotent Stem Cells into Cortical Neurons to Advance Precision Medicine. Methods Mol Biol. 2022; 2429:143-174. PMID: 35507160.
    Citations: 1
    Fields: MolMolecular BiologyTranslation:HumansCells
  19. Petrozziello T, Bordt EA, Mills AN, Kim SE, Sapp E, Devlin BA, Obeng-Marnu AA, Farhan SMK, Amaral AC, Dujardin S, Dooley PM, Henstridge C, Oakley DH, Neueder A, Hyman BT, Spires-Jones TL, Bilbo SD, Vakili K, Cudkowicz ME, Berry JD, DiFiglia M, Silva MC, Haggarty SJ, Sadri-Vakili G. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2022 Jan; 59(1):683-702. PMID: 34757590.
    Citations: 11
    Fields: MolMolecular BiologyNeuNeurologyTranslation:HumansCells
  20. Poli V, Pui-Yan Ma V, Di Gioia M, Broggi A, Benamar M, Chen Q, Mazitschek R, Haggarty SJ, Chatila TA, Karp JM, Zanoni I. Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation. iScience. 2021 Nov 19; 24(11):103256. PMID: 34761180; PMCID: PMC8567386.
    Citations: 20
  21. Bai P, Lan Y, Patnaik D, Wang H, Liu Y, Chen Z, Yuan G, Afshar S, Striar R, Zagaroli JS, Tocci DR, Langan AG, Haggarty SJ, Wang C. Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins. J Med Chem. 2021 10 14; 64(19):14745-14756. PMID: 34549949.
    Citations: 11
    Fields: CheChemistryTranslation:AnimalsCells
  22. Cheng C, Reis SA, Adams ET, Fass DM, Angus SP, Stuhlmiller TJ, Richardson J, Olafson H, Wang ET, Patnaik D, Beauchamp RL, Feldman DA, Silva MC, Sur M, Johnson GL, Ramesh V, Miller BL, Temple S, Kosik KS, Dickerson BC, Haggarty SJ. High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy. Sci Rep. 2021 08 23; 11(1):17029. PMID: 34426604.
    Citations: 6
    Fields: SciScienceTranslation:HumansCells
  23. Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, Goderie SK, Chowdhury R, Lotz S, Lane K, Crary JF, Haggarty SJ, Karch CM, Ichida JK, Goate AM, Temple S. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell. 2021 08 19; 184(17):4547-4563.e17. PMID: 34314701; PMCID: PMC8635409.
    Citations: 53
    Fields: CelCell BiologyTranslation:HumansCells
  24. Chang LS, Oblinger JL, Smith AE, Ferrer M, Angus SP, Hawley E, Petrilli AM, Beauchamp RL, Riecken LB, Erdin S, Poi M, Huang J, Bessler WK, Zhang X, Guha R, Thomas C, Burns SS, Gilbert TSK, Jiang L, Li X, Lu Q, Yuan J, He Y, Dixon SAH, Masters A, Jones DR, Yates CW, Haggarty SJ, La Rosa S, Welling DB, Stemmer-Rachamimov AO, Plotkin SR, Gusella JF, Guinney J, Morrison H, Ramesh V, Fernandez-Valle C, Johnson GL, Blakeley JO, Clapp DW, Synodos for NF2 Consortium. Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK. PLoS One. 2021; 16(7):e0252048. PMID: 34264955; PMCID: PMC8282008.
    Citations: 17
    Fields: MedMedicine (General)SciScienceTranslation:HumansAnimalsCells
  25. Walczyk-Mooradally A, Holborn J, Singh K, Tyler M, Patnaik D, Wesseling H, Brandon NJ, Steen J, Graether SP, Haggarty SJ, Lalonde J. Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK. J Neurochem. 2021 09; 158(5):1058-1073. PMID: 34077555; PMCID: PMC8390433.
    Citations: 7
    Fields: CheChemistryNeuNeurologyTranslation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.