Harvard Catalyst Profiles

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Raul Mostoslavsky, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA235412 (MOSTOSLAVSKY, RAUL) Feb 19, 2019 - Jan 31, 2024
    Mechanistic Understanding for the Role of Lin28b in Pancreatic Cancer Progression
    Role: Principal Investigator
  2. R01GM128448 (MOSTOSLAVSKY, RAUL) Feb 1, 2019 - Dec 31, 2022
    The histone deacetylase SIRT6 modulates Transcriptional pausing
    Role: Principal Investigator
  3. R21ES027931 (MOSTOSLAVSKY, RAUL) Sep 1, 2018 - Aug 31, 2020
    A high throughput assay to identify novel chromatin factors that regulate DNA repair
    Role: Principal Investigator
  4. R21CA198109 (MOSTOSLAVSKY, RAUL) May 15, 2015 - Apr 30, 2017
    Deciphering SIRT6-dependent metabolic liabilities in Pancreatic cancer
    Role: Principal Investigator
  5. R33ES025638 (MOSTOSLAVSKY, RAUL) May 4, 2015 - Aug 31, 2021
    Histone tails as an energy reservoir for mitochondrial function
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sebastian C, Ferrer C, Serra M, Choi JE, Ducano N, Mira A, Shah MS, Stopka SA, Perciaccante AJ, Isella C, Moya-Rull D, Vara-Messler M, Giordano S, Maldi E, Desai N, Capen DE, Medico E, Cetinbas M, Sadreyev RI, Brown D, Rivera MN, Sapino A, Breault DT, Agar NYR, Mostoslavsky R. A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Nat Commun. 2022 Mar 21; 13(1):1503. PMID: 35314684.
    Citations:    Fields:    
  2. Lubotzky A, Zemmour H, Neiman D, Gotkine M, Loyfer N, Piyanzin S, Ochana BL, Lehmann-Werman R, Cohen D, Moss J, Magenheim J, Loftus MF, Brais L, Ng K, Mostoslavsky R, Wolpin BM, Zick A, Maoz M, Grinshpun A, Kustanovich A, Makranz C, Cohen JE, Peretz T, Hubert A, Temper M, Salah A, Avniel-Polak S, Grozinsky-Glasberg S, Spalding KL, Rokach A, Kaplan T, Glaser B, Shemer R, Dor Y. Liquid biopsy reveals collateral tissue damage in cancer. JCI Insight. 2022 01 25; 7(2). PMID: 35076021.
    Citations:    Fields:    
  3. Martinez-Pastor B, Silveira GG, Clarke TL, Chung D, Gu Y, Cosentino C, Davidow LS, Mata G, Hassanieh S, Salsman J, Ciccia A, Bae N, Bedford MT, Megias D, Rubin LL, Efeyan A, Dellaire G, Mostoslavsky R. Assessing kinetics and recruitment of DNA repair factors using high content screens. Cell Rep. 2021 12 28; 37(13):110176. PMID: 34965416.
    Citations:    Fields:    Translation:HumansCells
  4. Gorbunova V, Buschbeck M, Cambronne XA, Chellappa K, Corda D, Du J, Freichel M, Gigas J, Green AE, Gu F, Guberovic I, Jayabalan A, Khansahib I, Mukherjee S, Seluanov A, Simon MA, Sverkeli LJ, Kory N, Levine DC, Matic I, Nikiforov A, Rack JGM, Imai SI, Sinclair DA, Toiber D, Zhao Y, Mostoslavsky R, Kraus L, Guse AH. The 2021 FASEB science research conference on NAD metabolism and signaling. Aging (Albany NY). 2021 Dec 09; 13(23):24924-24930. PMID: 34890368.
    Citations:    Fields:    
  5. Tomas-Grau RH, Ploper D, Ávila CL, Vera Pingitore E, Maldonado Galdeano C, Chaves S, Socias SB, Stagnetto A, Navarro SA, Chahla RE, Aguilar López M, Llapur CJ, Aznar P, Alcorta ME, Costas D, Flores I, Heinze D, Apfelbaum G, Mostoslavsky R, Mostoslavsky G, Cazorla SI, Perdigón GDV, Chehín R. Elevated Humoral Immune Response to SARS-CoV-2 at High Altitudes Revealed by an Anti-RBD "In-House" ELISA. Front Med (Lausanne). 2021; 8:720988. PMID: 34722566.
    Citations: 1     
  6. Guo H, Golczer G, Wittner BS, Langenbucher A, Zachariah M, Dubash TD, Hong X, Comaills V, Burr R, Ebright RY, Horwitz E, Vuille JA, Hajizadeh S, Wiley DF, Reeves BA, Zhang JM, Niederhoffer KL, Lu C, Wesley B, Ho U, Nieman LT, Toner M, Vasudevan S, Zou L, Mostoslavsky R, Maheswaran S, Lawrence MS, Haber DA. NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer. Mol Cell. 2021 10 07; 81(19):4041-4058.e15. PMID: 34624217.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Khan D, Ara T, Ravi V, Rajagopal R, Tandon H, Parvathy J, Gonzalez EA, Asirvatham-Jeyaraj N, Krishna S, Mishra S, Raghu S, Bhati AS, Tamta AK, Dasgupta S, Kolthur-Seetharam U, Etchegaray JP, Mostoslavsky R, Rao PSM, Srinivasan N, Sundaresan NR. SIRT6 transcriptionally regulates fatty acid transport by suppressing PPAR?. Cell Rep. 2021 06 01; 35(9):109190. PMID: 34077730.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Roach L, Mostoslavsky R. TiPpIng the balance in histone acetylation. Nat Metab. 2021 Jun; 3(6):729-731. PMID: 34140693.
    Citations:    Fields:    
  9. Choi JE, Sebastian C, Ferrer CM, Lewis CA, Sade-Feldman M, LaSalle T, Gonye A, Lopez BGC, Abdelmoula WM, Regan MS, Cetinbas M, Pascual G, Wojtkiewicz GR, Silveira GG, Boon R, Ross KN, Tirosh I, Saladi SV, Ellisen LW, Sadreyev RI, Benitah SA, Agar NYR, Hacohen N, Mostoslavsky R. A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma. Nat Metab. 2021 02; 3(2):182-195. PMID: 33619381.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Boon R, Silveira GG, Mostoslavsky R. Nuclear metabolism and the regulation of the epigenome. Nat Metab. 2020 11; 2(11):1190-1203. PMID: 33046909.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  11. Clarke TL, Mostoslavsky R. Resveratrol: Friend or Foe? Mol Cell. 2020 09 03; 79(5):705-707. PMID: 32888435.
    Citations:    Fields:    Translation:HumansAnimalsCells
  12. Arsiwala T, Pahla J, van Tits LJ, Bisceglie L, Gaul DS, Costantino S, Miranda MX, Nussbaum K, Stivala S, Blyszczuk P, Weber J, Tailleux A, Stein S, Paneni F, Beer JH, Greter M, Becher B, Mostoslavsky R, Eriksson U, Staels B, Auwerx J, Hottiger MO, Lüscher TF, Matter CM. Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1. J Mol Cell Cardiol. 2020 02; 139:24-32. PMID: 31972266.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  13. Jung SM, Hung CM, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Martinez Calejman C, Luciano AK, Hsiao WY, Tang Y, Li H, Daniels DL, Mostoslavsky R, Metallo CM, Guertin DA. Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1. Mol Cell. 2019 08 22; 75(4):807-822.e8. PMID: 31442424.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  14. Chang AR, Ferrer CM, Mostoslavsky R. SIRT6, a Mammalian Deacylase with Multitasking Abilities. Physiol Rev. 2020 01 01; 100(1):145-169. PMID: 31437090.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  15. Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, Nechaev S, Whetstine JR, Roeder RG, Adelman K, Goren A, Mostoslavsky R. The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. Mol Cell. 2019 08 22; 75(4):683-699.e7. PMID: 31399344.
    Citations: 21     Fields:    Translation:HumansCells
  16. Etchegaray JP, Mostoslavsky R. A sirtuin's role in preventing senescence by protecting ribosomal DNA. J Biol Chem. 2018 07 13; 293(28):11251-11252. PMID: 30006387.
    Citations: 2     Fields:    Translation:HumansCells
  17. Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality. Genes Dev. 2018 03 01; 32(5-6):373-388. PMID: 29555651.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  18. Lin JB, Kubota S, Mostoslavsky R, Apte RS. Role of Sirtuins in Retinal Function Under Basal Conditions. Adv Exp Med Biol. 2018; 1074:561-567. PMID: 29721988.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  19. Zorrilla-Zubilete MA, Yeste A, Quintana FJ, Toiber D, Mostoslavsky R, Silberman DM. Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6. J Neurochem. 2018 01; 144(2):128-138. PMID: 29049850.
    Citations: 14     Fields:    Translation:AnimalsCells
  20. Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM. TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov. 2017 11; 7(11):1336-1353. PMID: 28974511.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  21. Mostoslavsky R, Bardeesy N. Reprogramming Enhancers to Drive Metastasis. Cell. 2017 08 24; 170(5):823-825. PMID: 28841414.
    Citations: 7     Fields:    Translation:HumansCells
  22. Linder SJ, Mostoslavsky R. Put Your Mark Where Your Damage Is: Acetyl-CoA Production by ACLY Promotes DNA Repair. Mol Cell. 2017 Jul 20; 67(2):165-167. PMID: 28732204.
    Citations: 3     Fields:    Translation:Cells
  23. Sociali G, Magnone M, Ravera S, Damonte P, Vigliarolo T, Von Holtey M, Vellone VG, Millo E, Caffa I, Cea M, Parenti MD, Del Rio A, Murone M, Mostoslavsky R, Grozio A, Nencioni A, Bruzzone S. Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model. FASEB J. 2017 07; 31(7):3138-3149. PMID: 28386046.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  24. Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, Park PJ, Gygi SP, Meissner A, Hochedlinger K. DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells. Cell Stem Cell. 2017 05 04; 20(5):706-719.e7. PMID: 28366588.
    Citations: 30     Fields:    Translation:AnimalsCells
  25. Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, Ueberham U, Arendt T, Mostoslavsky R, Sahay A, Toiber D. Neuroprotective Functions for the Histone Deacetylase SIRT6. Cell Rep. 2017 03 28; 18(13):3052-3062. PMID: 28355558.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  26. Ioris RM, Galié M, Ramadori G, Anderson JG, Charollais A, Konstantinidou G, Brenachot X, Aras E, Goga A, Ceglia N, Sebastián C, Martinvalet D, Mostoslavsky R, Baldi P, Coppari R. SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity. Cell Rep. 2017 02 21; 18(8):1858-1868. PMID: 28228253.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  27. Sebastián C, Mostoslavsky R. The Various Metabolic Sources of Histone Acetylation. Trends Endocrinol Metab. 2017 02; 28(2):85-87. PMID: 27863854.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  28. Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, Shivdasani RA, Hochedlinger K. Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell Rep. 2016 08 16; 16(7):1929-41. PMID: 27498859.
    Citations: 32     Fields:    Translation:AnimalsCells
  29. Etchegaray JP, Mostoslavsky R. Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes. Mol Cell. 2016 06 02; 62(5):695-711. PMID: 27259202.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  30. Kugel S, Sebastián C, Fitamant J, Ross KN, Saha SK, Jain E, Gladden A, Arora KS, Kato Y, Rivera MN, Ramaswamy S, Sadreyev RI, Goren A, Deshpande V, Bardeesy N, Mostoslavsky R. SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b. Cell. 2016 Jun 02; 165(6):1401-1415. PMID: 27180906.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  31. Pastor BM, Mostoslavsky R. SIRT6: a new guardian of mitosis. Nat Struct Mol Biol. 2016 05 04; 23(5):360-2. PMID: 27142319.
    Citations:    Fields:    Translation:Humans
  32. Lasigliè D, Boero S, Bauer I, Morando S, Damonte P, Cea M, Monacelli F, Odetti P, Ballestrero A, Uccelli A, Mostoslavsky R, Poggi A, Nencioni A. Sirt6 regulates dendritic cell differentiation, maturation, and function. Aging (Albany NY). 2016 Jan; 8(1):34-49. PMID: 26761436.
    Citations: 11     Fields:    Translation:AnimalsCells
  33. Kugel S, Feldman JL, Klein MA, Silberman DM, Sebastián C, Mermel C, Dobersch S, Clark AR, Getz G, Denu JM, Mostoslavsky R. Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer. Cell Rep. 2015 Oct 20; 13(3):479-488. PMID: 26456828.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  34. Sebastián C, Mostoslavsky R. The role of mammalian sirtuins in cancer metabolism. Semin Cell Dev Biol. 2015 Jul; 43:33-42. PMID: 26238985.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  35. Gottlieb E, Mostoslavsky R. Cancer and metabolism: Why should we care? Semin Cell Dev Biol. 2015 Jul; 43:1-2. PMID: 26611348.
    Citations: 1     Fields:    Translation:Humans
  36. Etchegaray JP, Mostoslavsky R. Cell Fate by SIRT6 and TETs. Cell Cycle. 2015; 14(14):2187-8. PMID: 26066792.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  37. Singh I, Ozturk N, Cordero J, Mehta A, Hasan D, Cosentino C, Sebastian C, Krüger M, Looso M, Carraro G, Bellusci S, Seeger W, Braun T, Mostoslavsky R, Barreto G. High mobility group protein-mediated transcription requires DNA damage marker ?-H2AX. Cell Res. 2015 Jul; 25(7):837-50. PMID: 26045162.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  38. Etchegaray JP, Chavez L, Huang Y, Ross KN, Choi J, Martinez-Pastor B, Walsh RM, Sommer CA, Lienhard M, Gladden A, Kugel S, Silberman DM, Ramaswamy S, Mostoslavsky G, Hochedlinger K, Goren A, Rao A, Mostoslavsky R. The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine. Nat Cell Biol. 2015 May; 17(5):545-57. PMID: 25915124.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  39. Sebastián C, Mostoslavsky R. Untangling the fiber yarn: butyrate feeds Warburg to suppress colorectal cancer. Cancer Discov. 2014 Dec; 4(12):1368-70. PMID: 25477104.
    Citations: 8     Fields:    Translation:HumansAnimals
  40. Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect. 2014 Dec; 122(12):1271-8. PMID: 25127496.
    Citations: 97     Fields:    Translation:HumansCellsPHPublic Health
  41. Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Deng C, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P. Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell. 2014 Jul 31; 158(3):659-72. PMID: 25083875.
    Citations: 132     Fields:    Translation:AnimalsCells
  42. Choi JE, Mostoslavsky R. Sirtuins, metabolism, and DNA repair. Curr Opin Genet Dev. 2014 Jun; 26:24-32. PMID: 25005742.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  43. Cosentino C, Mostoslavsky R. Sirtuin to the rescue: SIRT2 extends life span of BubR1 mice. EMBO J. 2014 Jul 01; 33(13):1417-9. PMID: 24920578.
    Citations: 4     Fields:    Translation:HumansAnimals
  44. Silberman DM, Ross K, Sande PH, Kubota S, Ramaswamy S, Apte RS, Mostoslavsky R. SIRT6 is required for normal retinal function. PLoS One. 2014; 9(6):e98831. PMID: 24896097.
    Citations: 25     Fields:    Translation:AnimalsCells
  45. Kugel S, Mostoslavsky R. Chromatin and beyond: the multitasking roles for SIRT6. Trends Biochem Sci. 2014 Feb; 39(2):72-81. PMID: 24438746.
    Citations: 141     Fields:    Translation:HumansAnimalsCells
  46. Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 2013 Nov 14; 5(3):654-665. PMID: 24210820.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  47. Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R. SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling. Mol Cell. 2013 Aug 22; 51(4):454-68. PMID: 23911928.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  48. Martinez-Pastor B, Cosentino C, Mostoslavsky R. A tale of metabolites: the cross-talk between chromatin and energy metabolism. Cancer Discov. 2013 May; 3(5):497-501. PMID: 23658298.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  49. Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, Du J, Kim R, Ge E, Mostoslavsky R, Hang HC, Hao Q, Lin H. SIRT6 regulates TNF-a secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 2013 Apr 04; 496(7443):110-3. PMID: 23552949.
    Citations: 270     Fields:    Translation:HumansCells
  50. Cosentino C, Mostoslavsky R. Metabolism, longevity and epigenetics. Cell Mol Life Sci. 2013 May; 70(9):1525-41. PMID: 23467663.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  51. Kugel S, Mostoslavsky R. SIRT1 activators: the evidence STACks up. Aging (Albany NY). 2013 Mar; 5(3):142-3. PMID: 23474671.
    Citations: 2     Fields:    Translation:HumansAnimals
  52. Zhong L, Martinez-Pastor B, Silberman DM, Sebastian C, Mostoslavsky R. Assaying chromatin sirtuins. Methods Mol Biol. 2013; 1077:149-163. PMID: 24014405.
    Citations: 3     Fields:    Translation:HumansCells
  53. Etchegaray JP, Zhong L, Mostoslavsky R. The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease. Curr Top Med Chem. 2013; 13(23):2991-3000. PMID: 24171769.
    Citations: 26     Fields:    Translation:HumansAnimals
  54. Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 2012 Dec 07; 151(6):1185-99. PMID: 23217706.
    Citations: 294     Fields:    Translation:HumansAnimalsCells
  55. Dominy JE, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell. 2012 Dec 28; 48(6):900-13. PMID: 23142079.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  56. Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med. 2012 Nov; 18(11):1643-50. PMID: 23086477.
    Citations: 175     Fields:    Translation:AnimalsCells
  57. Sebastián C, Satterstrom FK, Haigis MC, Mostoslavsky R. From sirtuin biology to human diseases: an update. J Biol Chem. 2012 Dec 14; 287(51):42444-52. PMID: 23086954.
    Citations: 93     Fields:    Translation:Humans
  58. Bauer I, Grozio A, Lasigliè D, Basile G, Sturla L, Magnone M, Sociali G, Soncini D, Caffa I, Poggi A, Zoppoli G, Cea M, Feldmann G, Mostoslavsky R, Ballestrero A, Patrone F, Bruzzone S, Nencioni A. The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. J Biol Chem. 2012 Nov 30; 287(49):40924-37. PMID: 23086953.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  59. Montecucco F, Bauer I, Braunersreuther V, Bruzzone S, Akhmedov A, Lüscher TF, Speer T, Poggi A, Mannino E, Pelli G, Galan K, Bertolotto M, Lenglet S, Garuti A, Montessuit C, Lerch R, Pellieux C, Vuilleumier N, Dallegri F, Mage J, Sebastian C, Mostoslavsky R, Gayet-Ageron A, Patrone F, Mach F, Nencioni A. Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. Antioxid Redox Signal. 2013 Feb 20; 18(6):630-41. PMID: 22452634.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  60. Martinez-Pastor B, Mostoslavsky R. Sirtuins, metabolism, and cancer. Front Pharmacol. 2012; 3:22. PMID: 22363287.
    Citations: 27     
  61. Rottiers V, Najafi-Shoushtari SH, Kristo F, Gurumurthy S, Zhong L, Li Y, Cohen DE, Gerszten RE, Bardeesy N, Mostoslavsky R, Näär AM. MicroRNAs in metabolism and metabolic diseases. Cold Spring Harb Symp Quant Biol. 2011; 76:225-33. PMID: 22156303.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  62. Etchegaray JP, Mostoslavsky R. eNERgizing pluripotent gene transcription. Cell Stem Cell. 2011 Oct 04; 9(4):285-6. PMID: 21982224.
    Citations: 3     Fields:    
  63. Cohen-Kfir E, Artsi H, Levin A, Abramowitz E, Bajayo A, Gurt I, Zhong L, D'Urso A, Toiber D, Mostoslavsky R, Dresner-Pollak R. Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor. Endocrinology. 2011 Dec; 152(12):4514-24. PMID: 21952235.
    Citations: 82     Fields:    Translation:AnimalsCells
  64. Silberman DM, Mostoslavsky R. SIRT3 deacetylase: the Jekyll and Hyde sirtuin. EMBO Rep. 2011 Jul 08; 12(8):746-7. PMID: 21738223.
    Citations: 2     Fields:    Translation:Animals
  65. Zhong L, Mostoslavsky R. Fine tuning our cellular factories: sirtuins in mitochondrial biology. Cell Metab. 2011 Jun 08; 13(6):621-6. PMID: 21641544.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  66. Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM. A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell. 2011 Jun 10; 42(5):689-99. PMID: 21596603.
    Citations: 91     Fields:    Translation:Animals
  67. Guarani V, Deflorian G, Franco CA, Krüger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MHH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M. Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature. 2011 05 12; 473(7346):234-8. PMID: 21499261.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  68. Toiber D, Sebastian C, Mostoslavsky R. Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance. Handb Exp Pharmacol. 2011; 206:189-224. PMID: 21879451.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  69. Sebastian C, Mostoslavsky R. SIRT3 in calorie restriction: can you hear me now? Cell. 2010 Nov 24; 143(5):667-8. PMID: 21111225.
    Citations: 9     Fields:    
  70. Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan DA, Mostoslavsky R, Stuart RC, Perello M, Vianna CR, Nillni EA, Rahmouni K, Coppari R. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 2010 Jul 07; 12(1):78-87. PMID: 20620997.
    Citations: 124     Fields:    Translation:AnimalsCells
  71. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 01; 24(13):1403-17. PMID: 20595232.
    Citations: 169     Fields:    Translation:HumansAnimalsCells
  72. Zhong L, Mostoslavsky R. SIRT6: a master epigenetic gatekeeper of glucose metabolism. Transcription. 2010 Jul-Aug; 1(1):17-21. PMID: 21327158.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  73. Qin J, Van Buren D, Huang HS, Zhong L, Mostoslavsky R, Akbarian S, Hock H. Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. J Biol Chem. 2010 Sep 03; 285(36):27767-75. PMID: 20592034.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  74. Mostoslavsky R, Esteller M, Vaquero A. At the crossroad of lifespan, calorie restriction, chromatin and disease: meeting on sirtuins. Cell Cycle. 2010 May 15; 9(10):1907-12. PMID: 20458180.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  75. Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010 Jan 22; 140(2):280-93. PMID: 20141841.
    Citations: 457     Fields:    Translation:AnimalsCells
  76. Bruzzone S, Fruscione F, Morando S, Ferrando T, Poggi A, Garuti A, D'Urso A, Selmo M, Benvenuto F, Cea M, Zoppoli G, Moran E, Soncini D, Ballestrero A, Sordat B, Patrone F, Mostoslavsky R, Uccelli A, Nencioni A. Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE. PLoS One. 2009 Nov 19; 4(11):e7897. PMID: 19936064.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  77. Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature. 2009 Jul 30; 460(7255):587-91. PMID: 19641587.
    Citations: 626     Fields:    Translation:HumansAnimalsCells
  78. Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med. 2009 Feb; 15(2):206-10. PMID: 19151729.
    Citations: 118     Fields:    Translation:Animals
  79. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008 Nov 28; 135(5):907-18. PMID: 19041753.
    Citations: 367     Fields:    Translation:HumansAnimalsCells
  80. Bassing CH, Whitlow S, Mostoslavsky R, Mostoslovasky R, Yang-Iott K, Ranganath S, Alt FW. Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements. Eur J Immunol. 2008 Sep; 38(9):2564-72. PMID: 18792409.
    Citations: 6     Fields:    Translation:AnimalsCells
  81. Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F, Mostoslavsky R, Alt FW, Schibler U. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008 Jul 25; 134(2):317-28. PMID: 18662546.
    Citations: 569     Fields:    Translation:AnimalsCells
  82. Kahyo T, Mostoslavsky R, Goto M, Setou M. Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein. FEBS Lett. 2008 Jul 23; 582(17):2479-83. PMID: 18588880.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  83. Mostoslavsky R. DNA repair, insulin signaling and sirtuins: at the crossroads between cancer and aging. Front Biosci. 2008 May 01; 13:6966-90. PMID: 18508709.
    Citations: 6     Fields:    Translation:HumansCells
  84. Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3374-9. PMID: 18296641.
    Citations: 596     Fields:    Translation:HumansAnimalsCells
  85. Lombard DB, Schwer B, Alt FW, Mostoslavsky R. SIRT6 in DNA repair, metabolism and ageing. J Intern Med. 2008 Feb; 263(2):128-41. PMID: 18226091.
    Citations: 69     Fields:    Translation:AnimalsCells
  86. Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S. SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev. 2007 Oct 15; 21(20):2644-58. PMID: 17938244.
    Citations: 243     Fields:    Translation:HumansAnimalsCells
  87. Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. PMID: 17923681.
    Citations: 569     Fields:    Translation:AnimalsCells
  88. Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol. 2007 Jul; 8(7):715-22. PMID: 17546032.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  89. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007 Apr 04; 26(7):1913-23. PMID: 17347648.
    Citations: 536     Fields:    Translation:AnimalsCells
  90. Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006 Sep 08; 126(5):941-54. PMID: 16959573.
    Citations: 470     Fields:    Translation:HumansAnimalsCells
  91. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006 Jan 27; 124(2):315-29. PMID: 16439206.
    Citations: 683     Fields:    Translation:HumansAnimalsCells
  92. Jung D, Giallourakis C, Mostoslavsky R, Alt FW. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol. 2006; 24:541-70. PMID: 16551259.
    Citations: 247     Fields:    Translation:HumansAnimalsCells
  93. Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab. 2005 Jul; 2(1):67-76. PMID: 16054100.
    Citations: 102     Fields:    Translation:AnimalsCells
  94. Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW. DNA repair, genome stability, and aging. Cell. 2005 Feb 25; 120(4):497-512. PMID: 15734682.
    Citations: 352     Fields:    Translation:AnimalsCells
  95. Mostoslavsky R, Alt FW, Rajewsky K. The lingering enigma of the allelic exclusion mechanism. Cell. 2004 Sep 03; 118(5):539-44. PMID: 15339659.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  96. Mostoslavsky R, Alt FW. Receptor revision in T cells: an open question? Trends Immunol. 2004 Jun; 25(6):276-9. PMID: 15145316.
    Citations: 4     Fields:    Translation:AnimalsCells
  97. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 2004 Mar 26; 303(5666):2011-5. PMID: 14976264.
    Citations: 1300     Fields:    Translation:HumansAnimalsCells
  98. Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10794-9. PMID: 12960381.
    Citations: 501     Fields:    Translation:Animals
  99. Mostoslavsky R, Alt FW, Bassing CH. Chromatin dynamics and locus accessibility in the immune system. Nat Immunol. 2003 Jul; 4(7):603-6. PMID: 12830134.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  100. Mostoslavsky R, Singh N, Tenzen T, Goldmit M, Gabay C, Elizur S, Qi P, Reubinoff BE, Chess A, Cedar H, Bergman Y. Asynchronous replication and allelic exclusion in the immune system. Nature. 2001 Nov 08; 414(6860):221-5. PMID: 11700561.
    Citations: 81     Fields:    Translation:AnimalsCells
  101. Simon I, Tenzen T, Mostoslavsky R, Fibach E, Lande L, Milot E, Gribnau J, Grosveld F, Fraser P, Cedar H. Developmental regulation of DNA replication timing at the human beta globin locus. EMBO J. 2001 Nov 01; 20(21):6150-7. PMID: 11689454.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  102. Shemer R, Hershko AY, Perk J, Mostoslavsky R, Tsuberi B, Cedar H, Buiting K, Razin A. The imprinting box of the Prader-Willi/Angelman syndrome domain. Nat Genet. 2000 Dec; 26(4):440-3. PMID: 11101841.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  103. Mostoslavsky R, Kirillov A, Ji YH, Goldmit M, Holzmann M, Wirth T, Cedar H, Bergman Y. Demethylation and the establishment of kappa allelic exclusion. Cold Spring Harb Symp Quant Biol. 1999; 64:197-206. PMID: 11232285.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  104. Mostoslavsky R, Singh N, Kirillov A, Pelanda R, Cedar H, Chess A, Bergman Y. Kappa chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 1998 Jun 15; 12(12):1801-11. PMID: 9637682.
    Citations: 55     Fields:    Translation:AnimalsCells
  105. Bergman Y, Mostoslavsky R. DNA demethylation: turning genes on. Biol Chem. 1998 Apr-May; 379(4-5):401-7. PMID: 9628330.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  106. Mostoslavsky R, Bergman Y. DNA methylation: regulation of gene expression and role in the immune system. Biochim Biophys Acta. 1997 Aug 08; 1333(1):F29-50. PMID: 9294017.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  107. Kirillov A, Kistler B, Mostoslavsky R, Cedar H, Wirth T, Bergman Y. A role for nuclear NF-kappaB in B-cell-specific demethylation of the Igkappa locus. Nat Genet. 1996 Aug; 13(4):435-41. PMID: 8696338.
    Citations: 77     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.