Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Raul Mostoslavsky, M.D., Ph.D.

Title
Institution
Department
Address
Phone

Mentoring
current student opportunities
Available: 02/01/25, Expires: 06/30/25

Using a novel high-throughput assay, we discovered new chromatin factors with roles in DNA repair. One of them is a new ubiquitin ligase that appears to affect both transcription and DNA repair. From TCGA studies we found that upregulation of this protein correlates with decreased survival in pancreatic cancer patients, suggesting a critical role for this novel protein in cancer therapy resistance. In this project, we will take advantage of biochemistry, in vitro genetic and in vivo approaches to assess, using PDAC cancer cell lines and patient samples, roles for this factor in pancreatic cancer.


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R01CA279173 (MOSTOSLAVSKY, RAUL) Jul 1, 2024 - Jun 30, 2029
    NIH
    A novel, glutathione-dependent metabolic pathway drives metastatic outgrowth in pancreatic cancer
    Role: Principal Investigator
  2. R01CA235412 (MOSTOSLAVSKY, RAUL) Feb 19, 2019 - Jan 31, 2024
    NIH
    Mechanistic Understanding for the Role of Lin28b in Pancreatic Cancer Progression
    Role: Principal Investigator
  3. R01GM128448 (MOSTOSLAVSKY, RAUL) Feb 1, 2019 - Dec 31, 2022
    NIH
    The histone deacetylase SIRT6 modulates Transcriptional pausing
    Role: Principal Investigator
  4. R21ES027931 (MOSTOSLAVSKY, RAUL) Sep 1, 2018 - Aug 31, 2020
    NIH
    A high throughput assay to identify novel chromatin factors that regulate DNA repair
    Role: Principal Investigator
  5. R21CA198109 (MOSTOSLAVSKY, RAUL) May 15, 2015 - Apr 30, 2017
    NIH
    Deciphering SIRT6-dependent metabolic liabilities in Pancreatic cancer
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Updating...
This operation might take several minutes to complete. Please do not close your browser.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Mostoslavsky's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (499)
Explore
_
Co-Authors (101)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.