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Gilles A. Benichou, D.Sc., Ph.D.

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Mentoring
Available: 06/20/19, Expires: 06/05/20

We are investigating the immune response of T lymphocytes in transplant rejection models. Our main goal is to develop new therapies in transplantation.

The student will perform surgical procedures in mice and T cell ELISPOT assays in vitro to evaluate the immune response to allogeneic transplanted hearts and skins in mice.

Immunogenicity and Tolerogenicity of Peptide Antigens in Health and Disease
Part Time, 04/01/00 - 06/15/00
Immunogenicity and Tolerogenicity of Peptide Antigens in Health and Disease
Soma Weiss/Part Time, 04/01/00 - 06/15/00

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK115618 (BENICHOU, GILLES A) Dec 6, 2017 - Nov 30, 2021
    NIH/NIDDK
    Exosomes and Donor Antigen Cross-dressing in Pancreatic Islet Transplantation
    Role: Principal Investigator
  2. R21AI117466 (BENICHOU, GILLES A) Dec 15, 2016 - Nov 30, 2018
    NIH/NIAID
    B Cells in Tolerance and Chronic Rejection of Monkey Kidney Allografts
    Role: Principal Investigator
  3. R21AI124096 (BENICHOU, GILLES A) Jan 15, 2016 - Dec 31, 2017
    NIH/NIAID
    Exosomes and Donor MHC Cross-Dressing of Recipient Cells in Allotransplantation
    Role: Principal Investigator
  4. R21AI111191 (BENICHOU, GILLES A) Jan 1, 2015 - Dec 31, 2016
    NIH/NIAID
    Mechanisms Underlying Delayed Transplant Tolerance
    Role: Principal Investigator
  5. U19AI102405 (COSIMI, A BENEDICT) Aug 1, 2012 - Jul 31, 2017
    NIH/NIAID
    Approaches to Tolerance of Allogeneic Kidney and Islet Transplants
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Marino J, Gonzalez-Nolasco B, Wang X, Orent W, Benichou G. Contrasting effects of B cell depletion on CD4+ and CD8+ memory T cell responses generated after transplantation. Am J Transplant. 2020 Mar 17. PMID: 32185859.
    Citations:    
  2. Benichou G, Wang M, Ahrens K, Madsen JC. Extracellular vesicles in allograft rejection and tolerance. Cell Immunol. 2020 Mar; 349:104063. PMID: 32087929.
    Citations:    
  3. Hull TD, Benichou G, Madsen JC. Why some organ allografts are tolerated better than others: new insights for an old question. Curr Opin Organ Transplant. 2019 02; 24(1):49-57. PMID: 30516578.
    Citations:    Fields:    
  4. Robinson KA, Orent W, Madsen JC, Benichou G. Maintaining T cell tolerance of alloantigens: Lessons from animal studies. Am J Transplant. 2018 08; 18(8):1843-1856. PMID: 29939471.
    Citations:    Fields:    
  5. Benichou G, Prunevieille A. Graft-derived exosomes. When small vesicles play a big role in transplant rejection. Am J Transplant. 2018 07; 18(7):1585-1586. PMID: 29505692.
    Citations:    Fields:    
  6. Gonzalez-Nolasco B, Wang M, Prunevieille A, Benichou G. Emerging role of exosomes in allorecognition and allograft rejection. Curr Opin Organ Transplant. 2018 02; 23(1):22-27. PMID: 29189413.
    Citations: 1     Fields:    
  7. Benichou G, Kim J. Editorial: Allorecognition by Leukocytes of the Adaptive Immune System. Front Immunol. 2017; 8:1555. PMID: 29187852.
    Citations:    
  8. Benichou G, Gonzalez B, Marino J, Ayasoufi K, Valujskikh A. Role of Memory T Cells in Allograft Rejection and Tolerance. Front Immunol. 2017; 8:170. PMID: 28293238.
    Citations: 10     
  9. Firl DJ, Benichou G, Kim JI, Yeh H. A Paradigm Shift on the Question of B Cells in Transplantation? Recent Insights on Regulating the Alloresponse. Front Immunol. 2017; 8:80. PMID: 28210263.
    Citations:    
  10. Marino J, Paster J, Benichou G. Allorecognition by T Lymphocytes and Allograft Rejection. Front Immunol. 2016; 7:582. PMID: 28018349.
    Citations: 5     
  11. Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, Paster JT, LeGuern C, Germana S, Abdi R, Uehara M, Kim JI, Markmann JF, Tocco G, Benichou G. Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation. Sci Immunol. 2016 Jul 14; 1(1). PMID: 27942611.
    Citations: 3     Fields:    
  12. Hotta K, Aoyama A, Oura T, Yamada Y, Tonsho M, Huh KH, Kawai K, Schoenfeld D, Allan JS, Madsen JC, Benichou G, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T. Induced regulatory T cells in allograft tolerance via transient mixed chimerism. JCI Insight. 2016 Jul 07; 1(10). PMID: 27446989.
    Citations: 10     Fields:    
  13. Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, Paster JT, LeGuern C, Germana S, Abdi R, Uehara M, Kim JI, Markmann JF, Tocco G, Benichou G. Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation. Sci Immunol. 2016 Jul 14; 1(1):aaf8759. PMID: 28783676.
    Citations: 11     Fields:    
  14. Buhler L, Illigens BM, Nadazdin O, Tena A, Lee S, Sachs DH, Cooper DK, Benichou G. Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants. Am J Transplant. 2016 06; 16(6):1917-22. PMID: 26718119.
    Citations:    Fields:    Translation:AnimalsCells
  15. Marino J, Paster JT, Trowell A, Maxwell L, Briggs KH, Crosby Bertorini P, Benichou G. B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Responses After Transplantation. Am J Transplant. 2016 Feb; 16(2):672-8. PMID: 26552037.
    Citations: 6     Fields:    Translation:AnimalsCells
  16. Yamada Y, Nadazdin O, Boskovic S, Lee S, Zorn E, Smith RN, Colvin RB, Madsen JC, Cosimi AB, Kawai T, Benichou G. Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys. Am J Transplant. 2015 Dec; 15(12):3055-66. PMID: 26190648.
    Citations: 13     Fields:    Translation:Animals
  17. Lei J, Kim JI, Shi S, Zhang X, Machaidze Z, Lee S, Schuetz C, Martins PN, Oura T, Farkash EA, Rosales IA, Smith RN, Stott R, Lee KM, Soohoo J, Boskovic S, Cappetta K, Nadazdin OM, Yamada Y, Yeh H, Kawai T, Sachs DH, Benichou G, Markmann JF. Pilot Study Evaluating Regulatory T Cell-Promoting Immunosuppression and Nonimmunogenic Donor Antigen Delivery in a Nonhuman Primate Islet Allotransplantation Model. Am J Transplant. 2015 Oct; 15(10):2739-49. PMID: 26014796.
    Citations: 2     Fields:    Translation:AnimalsCells
  18. Tonsho M, Lee S, Aoyama A, Boskovic S, Nadazdin O, Capetta K, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T, Madsen JC, Benichou G, Allan JS. Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism. Am J Transplant. 2015 Aug; 15(8):2231-9. PMID: 25904524.
    Citations: 10     Fields:    Translation:Animals
  19. Aoyama A, Tonsho M, Ng CY, Lee S, Millington T, Nadazdin O, Wain JC, Cosimi AB, Sachs DH, Smith RN, Colvin RB, Kawai T, Madsen JC, Benichou G, Allan JS. Long-term lung transplantation in nonhuman primates. Am J Transplant. 2015 May; 15(5):1415-20. PMID: 25772308.
    Citations: 5     Fields:    Translation:AnimalsCells
  20. Granados JM, Benichou G, Kawai T. Hematopoietic stem cell infusion/transplantation for induction of allograft tolerance. Curr Opin Organ Transplant. 2015 Feb; 20(1):49-56. PMID: 25563992.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  21. Kant CD, Akiyama Y, Tanaka K, Shea S, Yamada Y, Connolly SE, Marino J, Tocco G, Benichou G. Both rejection and tolerance of allografts can occur in the absence of secondary lymphoid tissues. J Immunol. 2015 Feb 01; 194(3):1364-71. PMID: 25535285.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Yamada Y, Ochiai T, Boskovic S, Nadazdin O, Oura T, Schoenfeld D, Cappetta K, Smith RN, Colvin RB, Madsen JC, Sachs DH, Benichou G, Cosimi AB, Kawai T. Use of CTLA4Ig for induction of mixed chimerism and renal allograft tolerance in nonhuman primates. Am J Transplant. 2014 Dec; 14(12):2704-12. PMID: 25394378.
    Citations: 12     Fields:    Translation:HumansAnimals
  23. Wei M, Marino J, Trowell A, Zhang H, Stromp Peraino J, Rajasekera PV, Madsen JC, Sachs DH, Huang CA, Benichou G, Wang Z. Diphtheria toxin-based recombinant murine IL-2 fusion toxin for depleting murine regulatory T cells in vivo. Protein Eng Des Sel. 2014 Sep; 27(9):289-95. PMID: 25147093.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Lee S, Yamada Y, Tonsho M, Boskovic S, Nadazdin O, Schoenfeld D, Cappetta K, Atif M, Smith RN, Cosimi AB, Benichou G, Kawai T. Alefacept promotes immunosuppression-free renal allograft survival in nonhuman primates via depletion of recipient memory T cells. Am J Transplant. 2013 Dec; 13(12):3223-9. PMID: 24165326.
    Citations: 9     Fields:    Translation:AnimalsCells
  25. Benichou G, Nadazdin O, Cosimi AB, Kawai T. Successful tolerance to fully MHC disparate renal allografts via donor hematopoietic mixed chimerism in non-human primates. Am J Transplant. 2013 Sep; 13(9):2500. PMID: 23865775.
    Citations: 3     Fields:    Translation:Animals
  26. Kant CD, Akiyama Y, Tanaka K, Shea S, Connolly SE, Germana S, Winn HJ, LeGuern C, Tocco G, Benichou G. Primary vascularization of allografts governs their immunogenicity and susceptibility to tolerogenesis. J Immunol. 2013 Aug 15; 191(4):1948-56. PMID: 23833234.
    Citations: 5     Fields:    Translation:AnimalsCells
  27. Benichou G, Tocco G. The road to transplant tolerance is paved with good dendritic cells. Eur J Immunol. 2013 Mar; 43(3):584-8. PMID: 23412714.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Aoyama A, Klarin D, Yamada Y, Boskovic S, Nadazdin O, Kawai K, Schoenfeld D, Madsen JC, Cosimi AB, Benichou G, Kawai T. Low-dose IL-2 for In vivo expansion of CD4+ and CD8+ regulatory T cells in nonhuman primates. Am J Transplant. 2012 Sep; 12(9):2532-7. PMID: 22682297.
    Citations: 7     Fields:    Translation:AnimalsCells
  29. Yamada Y, Aoyama A, Tocco G, Boskovic S, Nadazdin O, Alessandrini A, Madsen JC, Cosimi AB, Benichou G, Kawai T. Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates. J Immunol. 2012 Jun 15; 188(12):6063-70. PMID: 22586034.
    Citations: 11     Fields:    Translation:AnimalsCells
  30. Benichou G, Tonsho M, Tocco G, Nadazdin O, Madsen JC. Innate immunity and resistance to tolerogenesis in allotransplantation. Front Immunol. 2012; 3:73. PMID: 22566954.
    Citations: 9     
  31. Burlingham WJ, Benichou G. Bidirectional alloreactivity: A proposed microchimerism-based solution to the NIMA paradox. Chimerism. 2012 Apr-Jun; 3(2):29-36. PMID: 22850252.
    Citations: 6     Fields:    Translation:HumansAnimals
  32. Millington T, Koulmanda M, Ng C, Boskovic S, Nadazdin OM, Benichou G, Zheng XX, Strom TB, Madsen JC. Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates. J Heart Lung Transplant. 2012 Apr; 31(4):427-35. PMID: 22366291.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  33. Yamada Y, Benichou G, Cosimi AB, Kawai T. Tolerance induction after organ transplantation, "delayed tolerance," via the mixed chimerism approach: planting flowers in a battle field. Chimerism. 2012 Jan-Mar; 3(1):24-8. PMID: 22690270.
    Citations: 1     Fields:    
  34. Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, Ochiai T, Nadazdin O, Koyama I, Boenisch O, Najafian N, Bhasin MK, Colvin RB, Madsen JC, Strom TB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates. Am J Transplant. 2012 Feb; 12(2):330-40. PMID: 22053723.
    Citations: 39     Fields:    Translation:AnimalsCells
  35. Nadazdin O, Boskovic S, Wee SL, Sogawa H, Koyama I, Colvin RB, Smith RN, Tocco G, O'Connor DH, Karl JA, Madsen JC, Sachs DH, Kawai T, Cosimi AB, Benichou G. Contributions of direct and indirect alloresponses to chronic rejection of kidney allografts in nonhuman primates. J Immunol. 2011 Nov 01; 187(9):4589-97. PMID: 21957140.
    Citations: 5     Fields:    Translation:AnimalsCells
  36. Levesque V, Bardwell PD, Shimizu I, Haspot F, Benichou G, Yeap BY, Sykes M. B-cell-dependent memory T cells impede nonmyeloablative mixed chimerism induction in presensitized mice. Am J Transplant. 2011 Nov; 11(11):2322-31. PMID: 21831158.
    Citations: 3     Fields:    Translation:AnimalsCells
  37. Veillette GR, Sahara H, Meltzer AJ, Weiss MJ, Iwamoto Y, Kim KM, Rosengard BR, Allan JS, Houser SL, Sachs DH, Benichou G, Madsen JC. Autoimmune sensitization to cardiac myosin leads to acute rejection of cardiac allografts in miniature swine. Transplantation. 2011 Jun 15; 91(11):1187-91. PMID: 21512437.
    Citations: 6     Fields:    Translation:AnimalsCellsPHPublic Health
  38. Nadazdin O, Boskovic S, Murakami T, Tocco G, Smith RN, Colvin RB, Sachs DH, Allan J, Madsen JC, Kawai T, Cosimi AB, Benichou G. Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates. Sci Transl Med. 2011 Jun 08; 3(86):86ra51. PMID: 21653831.
    Citations: 47     Fields:    Translation:AnimalsCells
  39. Benichou G, Yamada Y, Yun SH, Lin C, Fray M, Tocco G. Immune recognition and rejection of allogeneic skin grafts. Immunotherapy. 2011 Jun; 3(6):757-70. PMID: 21668313.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  40. Alessandrini A, De Haseth S, Fray M, Miyajima M, Colvin RB, Williams WW, Benedict Cosimi A, Benichou G. Dendritic cell maturation occurs through the inhibition of GSK-3ß. Cell Immunol. 2011; 270(2):114-25. PMID: 21601837.
    Citations: 1     Fields:    Translation:AnimalsCells
  41. Miyajima M, Chase CM, Alessandrini A, Farkash EA, Della Pelle P, Benichou G, Graham JA, Madsen JC, Russell PS, Colvin RB. Early acceptance of renal allografts in mice is dependent on foxp3(+) cells. Am J Pathol. 2011 Apr; 178(4):1635-45. PMID: 21435448.
    Citations: 32     Fields:    Translation:AnimalsCells
  42. Benichou G, Yamada Y, Aoyama A, Madsen JC. Natural killer cells in rejection and tolerance of solid organ allografts. Curr Opin Organ Transplant. 2011 Feb; 16(1):47-53. PMID: 21157342.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  43. Akiyama Y, Caucheteux SM, Vernochet C, Iwamoto Y, Tanaka K, Kanellopoulos-Langevin C, Benichou G. Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCR-transgenic mouse model. J Immunol. 2011 Feb 01; 186(3):1442-9. PMID: 21178009.
    Citations: 7     Fields:    Translation:AnimalsCells
  44. Graham JA, Fray M, de Haseth S, Lee KM, Lian MM, Chase CM, Madsen JC, Markmann J, Benichou G, Colvin RB, Cosimi AB, Deng S, Kim J, Alessandrini A. Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition. J Biol Chem. 2010 Oct 22; 285(43):32852-9. PMID: 20729209.
    Citations: 17     Fields:    Translation:AnimalsCells
  45. Nadazdin O, Boskovic S, Murakami T, O'Connor DH, Wiseman RW, Karl JA, Tuscher JJ, Sachs DH, Madsen JC, Tocco G, Kawai T, Cosimi AB, Benichou G. Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys. Am J Transplant. 2010 Jun; 10(6):1375-84. PMID: 20486921.
    Citations: 33     Fields:    Translation:AnimalsCells
  46. LeGuern C, Akiyama Y, Germana S, Tanaka K, Fernandez L, Iwamoto Y, Houser S, Benichou G. Intracellular MHC class II controls regulatory tolerance to allogeneic transplants. J Immunol. 2010 Mar 01; 184(5):2394-400. PMID: 20100928.
    Citations: 8     Fields:    Translation:AnimalsCells
  47. Illigens BM, Yamada A, Anosova N, Dong VM, Sayegh MH, Benichou G. Dual effects of the alloresponse by Th1 and Th2 cells on acute and chronic rejection of allotransplants. Eur J Immunol. 2009 Nov; 39(11):3000-9. PMID: 19658090.
    Citations: 12     Fields:    Translation:AnimalsCells
  48. Benichou G, Thomson AW. Direct versus indirect allorecognition pathways: on the right track. Am J Transplant. 2009 Apr; 9(4):655-6. PMID: 19344457.
    Citations: 9     Fields:    Translation:AnimalsCells
  49. Boisgérault F, Liu Y, Anosova N, Dana R, Benichou G. Differential roles of direct and indirect allorecognition pathways in the rejection of skin and corneal transplants. Transplantation. 2009 Jan 15; 87(1):16-23. PMID: 19136886.
    Citations: 20     Fields:    Translation:AnimalsCells
  50. Weiss MJ, Guenther DA, Mezrich JD, Sahara H, Ng CY, Meltzer AJ, Sayre JK, Cochrane ME, Pujara AC, Houser SL, Sachs DH, Rosengard BR, Allan JS, Benichou G, Madsen JC. The indirect alloresponse impairs the induction but not maintenance of tolerance to MHC class I-disparate allografts. Am J Transplant. 2009 Jan; 9(1):105-13. PMID: 19145702.
    Citations: 4     Fields:    Translation:Animals
  51. Ochiai T, Benichou G, Cosimi AB, Kawai T. Induction of allograft tolerance in nonhuman primates and humans. Front Biosci. 2007 May 01; 12:4248-53. PMID: 17485371.
    Citations: 4     Fields:    Translation:HumansAnimals
  52. Benichou G, Kant CD, Madsen J, Tocco G. Modulation of alloreactivity to MHC-derived peptides and transplantation tolerance. Front Biosci. 2007 May 01; 12:4239-47. PMID: 17485370.
    Citations:    Fields:    Translation:Humans
  53. Benichou G, Alessandrini A, Charrad RS, Wilkes DS. Induction of autoimmunity after allotransplantation. Front Biosci. 2007 May 01; 12:4362-9. PMID: 17485380.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  54. Koyama I, Nadazdin O, Boskovic S, Ochiai T, Smith RN, Sykes M, Sogawa H, Murakami T, Strom TB, Colvin RB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant. 2007 May; 7(5):1055-61. PMID: 17286617.
    Citations: 58     Fields:    Translation:AnimalsCells
  55. Tocco G, Illigens BM, Malfroy B, Benichou G. Prolongation of alloskin graft survival by catalytic scavengers of reactive oxygen species. Cell Immunol. 2006 Jun; 241(2):59-65. PMID: 16970930.
    Citations: 3     Fields:    Translation:AnimalsCells
  56. Bueter M, Gasser M, Schramm N, Lebedeva T, Tocco G, Gerstlauer C, Grimm M, Nichiporuk E, Thalheimer A, Thiede A, Meyer D, Benichou G, Waaga-Gasser AM. T-cell response to p53 tumor-associated antigen in patients with colorectal carcinoma. Int J Oncol. 2006 Feb; 28(2):431-8. PMID: 16391798.
    Citations: 6     Fields:    Translation:HumansCells
  57. Bueter M, Gasser M, Lebedeva T, Benichou G, Waaga-Gasser AM. Influence of p53 on anti-tumor immunity (review). Int J Oncol. 2006 Feb; 28(2):519-25. PMID: 16391808.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  58. Lechene C, Hillion F, McMahon G, Benson D, Kleinfeld AM, Kampf JP, Distel D, Luyten Y, Bonventre J, Hentschel D, Park KM, Ito S, Schwartz M, Benichou G, Slodzian G. High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry. J Biol. 2006; 5(6):20. PMID: 17010211.
    Citations: 79     Fields:    Translation:AnimalsCells
  59. Akiyama Y, Caucheteux SM, Iwamoto Y, Guimezanes A, Kanellopoulos-Langevin C, Benichou G. Effects of noninherited maternal antigens on allotransplant rejection in a transgenic mouse model. Transplant Proc. 2005 May; 37(4):1940-1. PMID: 15919511.
    Citations: 2     Fields:    Translation:AnimalsCells
  60. Huq S, Liu Y, Benichou G, Dana MR. Relevance of the direct pathway of sensitization in corneal transplantation is dictated by the graft bed microenvironment. J Immunol. 2004 Oct 01; 173(7):4464-9. PMID: 15383577.
    Citations: 41     Fields:    Translation:AnimalsCells
  61. Kurtz J, Shaffer J, Lie A, Anosova N, Benichou G, Sykes M. Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells. Blood. 2004 Jun 01; 103(11):4336-43. PMID: 14962909.
    Citations: 40     Fields:    Translation:AnimalsCells
  62. Andrassy J, Kusaka S, Jankowska-Gan E, Torrealba JR, Haynes LD, Marthaler BR, Tam RC, Illigens BM, Anosova N, Benichou G, Burlingham WJ. Tolerance to noninherited maternal MHC antigens in mice. J Immunol. 2003 Nov 15; 171(10):5554-61. PMID: 14607963.
    Citations: 36     Fields:    Translation:AnimalsCells
  63. Kim YM, Mapara MY, Down JD, Johnson KW, Boisgerault F, Akiyama Y, Benichou G, Pelot M, Zhao G, Sykes M. Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning. Blood. 2004 Jan 15; 103(2):732-9. PMID: 14512313.
    Citations: 3     Fields:    Translation:AnimalsCells
  64. Kurtz J, Lie A, Griffith M, Eysaman S, Shaffer J, Anosova N, Turka L, Benichou G, Sykes M. Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L. Am J Transplant. 2003 Jul; 3(7):804-16. PMID: 12814472.
    Citations: 8     Fields:    Translation:AnimalsCells
  65. Andersson G, Illigens BM, Johnson KW, Calderhead D, LeGuern C, Benichou G, White-Scharf ME, Down JD. Nonmyeloablative conditioning is sufficient to allow engraftment of EGFP-expressing bone marrow and subsequent acceptance of EGFP-transgenic skin grafts in mice. Blood. 2003 Jun 01; 101(11):4305-12. PMID: 12576326.
    Citations: 22     Fields:    Translation:AnimalsCells
  66. Qian Y, Hamrah P, Boisgerault F, Yamagami S, Vora S, Benichou G, Dana MR. Mechanisms of immunotherapeutic intervention by anti-CD154 (CD40L) antibody in high-risk corneal transplantation. J Interferon Cytokine Res. 2002 Dec; 22(12):1217-25. PMID: 12581495.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  67. Rolls HK, Kishimoto K, Dong VM, Illigens BM, Sho M, Sayegh MH, Benichou G, Fedoseyeva EV. T-cell response to cardiac myosin persists in the absence of an alloimmune response in recipients with chronic cardiac allograft rejection. Transplantation. 2002 Oct 15; 74(7):1053-7. PMID: 12394855.
    Citations: 16     Fields:    Translation:AnimalsCells
  68. Illigens BM, Yamada A, Fedoseyeva EV, Anosova N, Boisgerault F, Valujskikh A, Heeger PS, Sayegh MH, Boehm B, Benichou G. The relative contribution of direct and indirect antigen recognition pathways to the alloresponse and graft rejection depends upon the nature of the transplant. Hum Immunol. 2002 Oct; 63(10):912-25. PMID: 12368044.
    Citations: 9     Fields:    Translation:AnimalsCells
  69. Fedoseyeva EV, Kishimoto K, Rolls HK, Illigens BM, Dong VM, Valujskikh A, Heeger PS, Sayegh MH, Benichou G. Modulation of tissue-specific immune response to cardiac myosin can prolong survival of allogeneic heart transplants. J Immunol. 2002 Aug 01; 169(3):1168-74. PMID: 12133936.
    Citations: 21     Fields:    Translation:AnimalsCells
  70. Valujskikh A, Fedoseyeva E, Benichou G, Heeger PS. Development of autoimmunity after skin graft rejection via an indirect alloresponse. Transplantation. 2002 Apr 15; 73(7):1130-7. PMID: 11965045.
    Citations: 8     Fields:    Translation:AnimalsCells
  71. Najafian N, Salama AD, Fedoseyeva EV, Benichou G, Sayegh MH. Enzyme-linked immunosorbent spot assay analysis of peripheral blood lymphocyte reactivity to donor HLA-DR peptides: potential novel assay for prediction of outcomes for renal transplant recipients. J Am Soc Nephrol. 2002 Jan; 13(1):252-9. PMID: 11752045.
    Citations: 28     Fields:    Translation:HumansCells
  72. Rolls HK, Kishimoto K, Illigens BM, Dong V, Sayegh MH, Benichou G, Fedoseyeva EV. Detection of cardiac myosin-specific autoimmunity in a model of chronic heart allograft rejection. Transplant Proc. 2001 Nov-Dec; 33(7-8):3821-2. PMID: 11750627.
    Citations: 4     Fields:    Translation:AnimalsCells
  73. Anosova NG, Illigens B, Boisgérault F, Fedoseyeva EV, Young MJ, Benichou G. Antigenicity and immunogenicity of allogeneic retinal transplants. J Clin Invest. 2001 Oct; 108(8):1175-83. PMID: 11602625.
    Citations: 3     Fields:    Translation:AnimalsCells
  74. Boisgérault F, Liu Y, Anosova N, Ehrlich E, Dana MR, Benichou G. Role of CD4+ and CD8+ T cells in allorecognition: lessons from corneal transplantation. J Immunol. 2001 Aug 15; 167(4):1891-9. PMID: 11489968.
    Citations: 36     Fields:    Translation:AnimalsCells
  75. Yamada A, Kishimoto K, Dong VM, Sho M, Salama AD, Anosova NG, Benichou G, Mandelbrot DA, Sharpe AH, Turka LA, Auchincloss H, Sayegh MH. CD28-independent costimulation of T cells in alloimmune responses. J Immunol. 2001 Jul 01; 167(1):140-6. PMID: 11418642.
    Citations: 26     Fields:    Translation:AnimalsCells
  76. Qian Y, Boisgerault F, Benichou G, Dana MR. Blockade of CD40-CD154 costimulatory pathway promotes survival of allogeneic corneal transplants. Invest Ophthalmol Vis Sci. 2001 Apr; 42(5):987-94. PMID: 11274076.
    Citations: 9     Fields:    Translation:AnimalsCells
  77. Boisgérault F, Anosova N, Fedoseyeva EV, Tam RC, Benichou G. Analysis of T-cell response using altered peptide ligands. Methods Mol Biol. 2001; 156:211-8. PMID: 11068762.
    Citations:    Fields:    Translation:AnimalsCells
  78. Boisgérault F, Anosova NG, Tam RC, Illigens BM, Fedoseyeva EV, Benichou G. Induction of T-cell response to cryptic MHC determinants during allograft rejection. Hum Immunol. 2000 Dec; 61(12):1352-62. PMID: 11163093.
    Citations: 9     Fields:    Translation:AnimalsCells
  79. Kishimoto K, Dong VM, Issazadeh S, Fedoseyeva EV, Waaga AM, Yamada A, Sho M, Benichou G, Auchincloss H, Grusby MJ, Khoury SJ, Sayegh MH. The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest. 2000 Jul; 106(1):63-72. PMID: 10880049.
    Citations: 26     Fields:    Translation:AnimalsCells
  80. Fedoseyeva EV, Boisgérault F, Anosova NG, Wollish WS, Arlotta P, Jensen PE, Ono SJ, Benichou G. CD4+ T cell responses to self- and mutated p53 determinants during tumorigenesis in mice. J Immunol. 2000 Jun 01; 164(11):5641-51. PMID: 10820239.
    Citations: 6     Fields:    Translation:AnimalsCells
  81. Benichou G, Price VH. T cell repertoire in mice with alopecia areata. J Investig Dermatol Symp Proc. 1999 Dec; 4(3):224-5. PMID: 10674371.
    Citations: 3     Fields:    Translation:AnimalsCells
  82. Fedoseyeva EV, Zhang F, Orr PL, Levin D, Buncke HJ, Benichou G. De novo autoimmunity to cardiac myosin after heart transplantation and its contribution to the rejection process. J Immunol. 1999 Jun 01; 162(11):6836-42. PMID: 10352305.
    Citations: 35     Fields:    Translation:AnimalsCells
  83. Benichou G. Direct and indirect antigen recognition: the pathways to allograft immune rejection. Front Biosci. 1999 May 15; 4:D476-80. PMID: 10331992.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  84. Benichou G, Valujskikh A, Heeger PS. Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice. J Immunol. 1999 Jan 01; 162(1):352-8. PMID: 9886406.
    Citations: 78     Fields:    Translation:AnimalsCells
  85. Benichou G, Malloy KM, Tam RC, Heeger PS, Fedoseyeva EV. The presentation of self and allogeneic MHC peptides to T lymphocytes. Hum Immunol. 1998 Sep; 59(9):540-8. PMID: 9757910.
    Citations: 4     Fields:    Translation:HumansCells
  86. Soares LR, Orr PL, Garovoy MR, Benichou G. Differential activation of T cells by natural antigen peptide analogues: influence on autoimmune and alloimmune in vivo T cell responses. J Immunol. 1998 May 15; 160(10):4768-75. PMID: 9590223.
    Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
  87. Lehmann PV, Matesic D, Benichou G, Heeger PS. Induction of T helper 2 immunity to an immunodominant allopeptide. Transplantation. 1997 Jul 27; 64(2):292-6. PMID: 9256190.
    Citations: 2     Fields:    Translation:AnimalsCells
  88. Malfroy B, Doctrow SR, Orr PL, Tocco G, Fedoseyeva EV, Benichou G. Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites. Cell Immunol. 1997 Apr 10; 177(1):62-8. PMID: 9140096.
    Citations: 11     Fields:    Translation:AnimalsCells
  89. Goilav C, Zuckerman J, Lafrenz M, Vidor E, Briantais P, Lauwers S, Ratheau C, Benichou G, Zuckerman A. Persistence of antibodies after inactivated hepatitis A vaccines in a comparative study. J Infect. 1997 Mar; 34(2):158. PMID: 9138144.
    Citations: 1     Fields:    Translation:HumansCells
  90. Benichou G, Tam RC, Soares LR, Fedoseyeva EV. Indirect T-cell allorecognition: perspectives for peptide-based therapy in transplantation. Immunol Today. 1997 Feb; 18(2):67-71. PMID: 9057356.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  91. Benichou G, Tam RC, Soares LR, Popov IA, Garovoy MR, Fedoseyeva EV. The influence of two distinct alloresponse pathways on the design of peptide-based strategies for allograft tolerance. Res Immunol. 1996 Jul-Aug; 147(6):377-87. PMID: 8903104.
    Citations:    Fields:    Translation:HumansAnimalsCells
  92. Tam RC, Fedoseyeva EV, Moskalenko M, Garovoy MR, Benichou G. T cell tolerance is influenced by concomitant T cell recognition of cross-reactive self-peptides. J Immunol. 1996 May 15; 156(10):3765-71. PMID: 8621912.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
  93. Fedoseyeva EV, Tam RC, Popov IA, Orr PL, Garovoy MR, Benichou G. Induction of T cell responses to a self-antigen following allotransplantation. Transplantation. 1996 Mar 15; 61(5):679-83. PMID: 8607166.
    Citations: 7     Fields:    Translation:AnimalsCells
  94. Benichou G, Fedoseyeva EV. The contribution of peptides to T cell allorecognition and allograft rejection. Int Rev Immunol. 1996; 13(3):231-43. PMID: 8782744.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  95. Benichou G, Tam RC, Orr PI, Garovoy MR, Fedoseyeva EV. Self determinant selection and acquisition of the autoimmune T cell repertoire. Immunol Res. 1996; 15(3):234-45. PMID: 8902578.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  96. Popov IA, Fedoseyeva EV, Orr PL, Garovoy MR, Benichou G. Direct evidence for in vivo induction of CD8+ cytotoxic T cells directed to donor MHC class I peptides following mouse allotransplantation. Transplantation. 1995 Dec 27; 60(12):1621-4. PMID: 8545902.
    Citations: 9     Fields:    Translation:AnimalsCells
  97. Fedoseyeva EV, Tam RC, Orr PL, Garovoy MR, Benichou G. Presentation of a self-peptide for in vivo tolerance induction of CD4+ T cells is governed by a processing factor that maps to the class II region of the major histocompatibility complex locus. J Exp Med. 1995 Nov 01; 182(5):1481-91. PMID: 7595218.
    Citations: 3     Fields:    Translation:AnimalsCells
  98. Goilav C, Zuckerman J, Lafrenz M, Vidor E, Lauwers S, Ratheau C, Benichou G, Zuckerman A. Immunogenicity and safety of a new inactivated hepatitis A vaccine in a comparative study. J Med Virol. 1995 Jul; 46(3):287-92. PMID: 7561805.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  99. Benichou G, Cloarec MC, Montheil C. [Psychic and somatic]. Soins Psychiatr. 1995; (178):21-3. PMID: 8701360.
    Citations:    Fields:    Translation:Humans
  100. Benichou G, Fedoseyeva E, Lehmann PV, Olson CA, Geysen HM, McMillan M, Sercarz EE. Limited T cell response to donor MHC peptides during allograft rejection. Implications for selective immune therapy in transplantation. J Immunol. 1994 Aug 01; 153(3):938-45. PMID: 7517977.
    Citations: 12     Fields:    Translation:AnimalsCells
  101. Fedoseyeva EV, Li Y, Huey B, Tam S, Hunt CA, Benichou G, Garovoy MR. Inhibition of interferon-gamma-mediated immune functions by oligonucleotides. Suppression of human T cell proliferation by downregulation of IFN-gamma-induced ICAM-1 and Fc-receptor on accessory cells. Transplantation. 1994 Feb 27; 57(4):606-12. PMID: 7906904.
    Citations:    Fields:    Translation:HumansCells
  102. Algazi M, Ancelle-Park R, Asjo B, Barin F, Barme M, Barre-Sinoussi F, Baylon H, Benichou J, Benichou G, Bezeaud A, et al. Appeal to Mitterrand in blood scandal. Nature. 1994 Jan 27; 367(6461):312. PMID: 8114928.
    Citations:    Fields:    Translation:HumansCells
  103. Benichou G, Fedoseyeva E, Olson CA, Geysen HM, McMillan M, Sercarz EE. Disruption of the determinant hierarchy on a self-MHC peptide: concomitant tolerance induction to the dominant determinant and priming to the cryptic self-determinant. Int Immunol. 1994 Jan; 6(1):131-8. PMID: 7511927.
    Citations: 4     Fields:    Translation:AnimalsCells
  104. Sercarz EE, Lehmann PV, Ametani A, Benichou G, Miller A, Moudgil K. Dominance and crypticity of T cell antigenic determinants. Annu Rev Immunol. 1993; 11:729-66. PMID: 7682817.
    Citations: 183     Fields:    Translation:HumansAnimalsCells
  105. Benichou G, Takizawa PA, Olson CA, McMillan M, Sercarz EE. Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection. J Exp Med. 1992 Jan 01; 175(1):305-8. PMID: 1730925.
    Citations: 42     Fields:    Translation:AnimalsCells
  106. Gammon G, Sercarz EE, Benichou G. The dominant self and the cryptic self: shaping the autoreactive T-cell repertoire. Immunol Today. 1991 Jun; 12(6):193-5. PMID: 1715167.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  107. Leca G, Benichou G, Bensussan A, Mitenne F, Galanaud P, Vazquez A. Respiratory burst in human B lymphocytes. Triggering of surface Ig receptors induces modulation of chemiluminescence signal. J Immunol. 1991 May 15; 146(10):3542-9. PMID: 1851193.
    Citations: 4     Fields:    Translation:HumansCells
  108. Benichou G, Takizawa PA, Ho PT, Killion CC, Olson CA, McMillan M, Sercarz EE. Immunogenicity and tolerogenicity of self-major histocompatibility complex peptides. J Exp Med. 1990 Nov 01; 172(5):1341-6. PMID: 1700053.
    Citations: 21     Fields:    Translation:AnimalsCells
  109. Benichou G, Sercarz E. The presentation of self-peptides: tolerance and competition. Int Rev Immunol. 1990; 6(1):75-88. PMID: 1715376.
    Citations:    Fields:    Translation:AnimalsCells
  110. Benichou G, Kanellopoulos JM, Mitenne F, Galanaud P, Leca G. T-cell chemiluminescence. A novel aspect of T-cell membrane activation studied with a Jurkat tumour cell line. Scand J Immunol. 1989 Aug; 30(2):265-9. PMID: 2788303.
    Citations: 1     Fields:    Translation:HumansCells
  111. Leca G, Benichou G, Bensussan A, Kanellopoulos J. Biochemical purification of various receptor molecules involved in human T lymphocyte activation. Separation of 9.3 antigen from the T cell receptor for antigen. Scand J Immunol. 1988 May; 27(5):573-85. PMID: 3259722.
    Citations: 1     Fields:    Translation:HumansCells
  112. Benichou G, Dormont D, Herodin F, Pasquier C. [Influence of gamma irradiation on the chemiluminescence of alveolar macrophages in guinea pigs at rest or activated]. C R Acad Sci III. 1988; 306(12):357-62. PMID: 3132312.
    Citations:    Fields:    Translation:AnimalsCells
  113. Benichou G, Kanellopoulos JM, Wallon C, Boue F, Delfraissy JF. Interferon-gamma restores T lymphocyte proliferation of nonresponders to IgG1 anti-CD3 via the induction of Fc gamma 1 receptors on monocytes. Eur J Immunol. 1987 Aug; 17(8):1175-81. PMID: 2957217.
    Citations: 1     Fields:    Translation:HumansCells
  114. Herodin F, Benichou G. Transient suppression of the zymosan-induced chemiluminescence produced by bone marrow cells during a subcutaneous nonspecific inflammation in the mouse. J Leukoc Biol. 1987 Jul; 42(1):76-83. PMID: 3474335.
    Citations:    Fields:    Translation:AnimalsCells
  115. Benichou G, Voisin GA. Antibody bipolar bridging: isotype-dependent signals given to guinea pig alveolar macrophages by anti-MHC alloantibodies. Cell Immunol. 1987 May; 106(2):304-17. PMID: 2952286.
    Citations: 5     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.