Harvard Catalyst Profiles

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Stephen D. Liberles, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK122976 (LOWELL, BRADFORD B) Sep 17, 2019 - Jun 30, 2024
    Leveraging the Rich Genetic Diversity of Vagal Motor Neurons to Decode Brain-to-Gut Communication
    Role: Co-Principal Investigator
  2. DP1AT009497 (LIBERLES, STEPHEN DANIEL) Sep 30, 2016 - Jul 31, 2021
    Sensory receptors of the vagus nerve
    Role: Principal Investigator
  3. OT2OD023848 (SHIVKUMAR, KALYANAM) Sep 24, 2016 - Jun 30, 2022
    Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous System
    Role: Co-Principal Investigator
  4. R01HL132255 (LIBERLES, STEPHEN DANIEL) May 15, 2016 - Jan 31, 2021
    Sensory biology of respiratory control neurons in the vagus nerve
    Role: Principal Investigator
  5. R01DK103703 (LIBERLES, STEPHEN DANIEL) Mar 1, 2016 - Dec 31, 2020
    Charting Vagal Circuits Containing Glucagon-Like Peptide 1 Receptor
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ran C, Boettcher JC, Kaye JA, Gallori CE, Liberles SD. Publisher Correction: A brainstem map for visceral sensations. Nature. 2022 Nov; 611(7934):E6. PMID: 36241717; PMCID: PMC9630126.
    Citations:    Fields:    
  2. Ran C, Boettcher JC, Kaye JA, Gallori CE, Liberles SD. A brainstem map for visceral sensations. Nature. 2022 09; 609(7926):320-326. PMID: 36045291; PMCID: PMC9452305.
    Citations: 1     Fields:    Translation:Cells
  3. Zhang C, Vincelette LK, Reimann F, Liberles SD. A brainstem circuit for nausea suppression. Cell Rep. 2022 06 14; 39(11):110953. PMID: 35705049; PMCID: PMC9260880.
    Citations:    Fields:    Translation:AnimalsCells
  4. Prescott SL, Liberles SD. Internal senses of the vagus nerve. Neuron. 2022 02 16; 110(4):579-599. PMID: 35051375; PMCID: PMC8857038.
    Citations: 1     Fields:    Translation:Cells
  5. Fei A, Wu W, Tan L, Tang C, Xu Z, Huo X, Bao H, Kong Y, Johnson M, Hartmann G, Talay M, Yang C, Riegler C, Herrera KJ, Engert F, Xie XS, Barnea G, Liberles SD, Yang H, Li Q. Coordination of two enhancers drives expression of olfactory trace amine-associated receptors. Nat Commun. 2021 06 18; 12(1):3798. PMID: 34145235; PMCID: PMC8213717.
    Citations: 3     Fields:    Translation:AnimalsCells
  6. Tao J, Campbell JN, Tsai LT, Wu C, Liberles SD, Lowell BB. Highly selective brain-to-gut communication via genetically defined vagus neurons. Neuron. 2021 07 07; 109(13):2106-2115.e4. PMID: 34077742; PMCID: PMC8273126.
    Citations: 7     Fields:    Translation:AnimalsCells
  7. Oh Y, Lai JS, Min S, Huang HW, Liberles SD, Ryoo HD, Suh GSB. Periphery signals generated by Piezo-mediated stomach stretch and Neuromedin-mediated glucose load regulate the Drosophila brain nutrient sensor. Neuron. 2021 06 16; 109(12):1979-1995.e6. PMID: 34015253; PMCID: PMC8611812.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Horio N, Liberles SD. Hunger enhances food-odour attraction through a neuropeptide Y spotlight. Nature. 2021 04; 592(7853):262-266. PMID: 33658716; PMCID: PMC8035273.
    Citations: 6     Fields:    Translation:AnimalsCells
  9. Min S, Oh Y, Verma P, Whitehead SC, Yapici N, Van Vactor D, Suh GS, Liberles S. Control of feeding by Piezo-mediated gut mechanosensation in Drosophila. Elife. 2021 02 18; 10. PMID: 33599608; PMCID: PMC7920550.
    Citations: 13     Fields:    Translation:AnimalsCells
  10. Zhang C, Kaye JA, Cai Z, Wang Y, Prescott SL, Liberles SD. Area Postrema Cell Types that Mediate Nausea-Associated Behaviors. Neuron. 2021 02 03; 109(3):461-472.e5. PMID: 33278342; PMCID: PMC7864887.
    Citations: 23     Fields:    Translation:AnimalsCells
  11. Prescott SL, Umans BD, Williams EK, Brust RD, Liberles SD. An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents. Cell. 2020 04 30; 181(3):574-589.e14. PMID: 32259485.
    Citations: 35     Fields:    Translation:AnimalsCells
  12. Min S, Chang RB, Prescott SL, Beeler B, Joshi NR, Strochlic DE, Liberles SD. Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws. Cell Rep. 2019 11 19; 29(8):2192-2201.e3. PMID: 31747594.
    Citations: 20     Fields:    Translation:AnimalsCells
  13. Li C, Navarrete J, Liang-Guallpa J, Lu C, Funderburk SC, Chang RB, Liberles SD, Olson DP, Krashes MJ. Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State. Cell Metab. 2019 03 05; 29(3):681-694.e5. PMID: 30472090.
    Citations: 34     Fields:    Translation:AnimalsCells
  14. Zeng WZ, Marshall KL, Min S, Daou I, Chapleau MW, Abboud FM, Liberles SD, Patapoutian A. PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. Science. 2018 10 26; 362(6413):464-467. PMID: 30361375; PMCID: PMC6563913.
    Citations: 103     Fields:    Translation:AnimalsCells
  15. Osakada T, Ishii KK, Mori H, Eguchi R, Ferrero DM, Yoshihara Y, Liberles SD, Miyamichi K, Touhara K. Sexual rejection via a vomeronasal receptor-triggered limbic circuit. Nat Commun. 2018 10 26; 9(1):4463. PMID: 30367054.
    Citations: 14     Fields:    Translation:AnimalsCells
  16. Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Author Correction: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 Oct; 24(10):1625-1626. PMID: 30013196.
    Citations: 2     Fields:    
  17. Umans BD, Liberles SD. Neural Sensing of Organ Volume. Trends Neurosci. 2018 12; 41(12):911-924. PMID: 30143276; PMCID: PMC6252275.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  18. Adams JM, Pei H, Sandoval DA, Seeley RJ, Chang RB, Liberles SD, Olson DP. Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons. Diabetes. 2018 08; 67(8):1538-1548. PMID: 29776968; PMCID: PMC6054439.
    Citations: 38     Fields:    Translation:AnimalsCells
  19. Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 05; 24(4):417-426. PMID: 29505031; PMCID: PMC6263165.
    Citations: 116     Fields:    Translation:AnimalsCells
  20. Nonomura K, Woo SH, Chang RB, Gillich A, Qiu Z, Francisco AG, Ranade SS, Liberles SD, Patapoutian A. Piezo2 senses airway stretch and mediates lung inflation-induced apnoea. Nature. 2017 01 12; 541(7636):176-181. PMID: 28002412.
    Citations: 128     Fields:    Translation:AnimalsCells
  21. Lou S, Adam Y, Weinstein EN, Williams E, Williams K, Parot V, Kavokine N, Liberles S, Madisen L, Zeng H, Cohen AE. Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse. J Neurosci. 2016 10 26; 36(43):11059-11073. PMID: 27798186.
    Citations: 42     Fields:    Translation:AnimalsCells
  22. Williams EK, Chang RB, Strochlic DE, Umans BD, Lowell BB, Liberles SD. Sensory Neurons that Detect Stretch and Nutrients in the Digestive System. Cell. 2016 Jun 30; 166(1):209-21. PMID: 27238020.
    Citations: 183     Fields:    Translation:AnimalsCells
  23. Stowers L, Liberles SD. State-dependent responses to sex pheromones in mouse. Curr Opin Neurobiol. 2016 06; 38:74-9. PMID: 27093585; PMCID: PMC4921285.
    Citations: 31     Fields:    Translation:AnimalsCells
  24. Li Q, Tachie-Baffour Y, Liu Z, Baldwin MW, Kruse AC, Liberles SD. Non-classical amine recognition evolved in a large clade of olfactory receptors. Elife. 2015 Oct 31; 4:e10441. PMID: 26519734.
    Citations: 19     Fields:    Translation:Animals
  25. Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med. 2015 May; 21(5):518-23. PMID: 25915831; PMCID: PMC4450999.
    Citations: 74     Fields:    Translation:AnimalsCells
  26. Chang RB, Strochlic DE, Williams EK, Umans BD, Liberles SD. Vagal Sensory Neuron Subtypes that Differentially Control Breathing. Cell. 2015 Apr 23; 161(3):622-633. PMID: 25892222.
    Citations: 148     Fields:    Translation:AnimalsCells
  27. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C. Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2015 Feb 06; 4:e06720. PMID: 25658835.
    Citations: 4     Fields:    
  28. Li Q, Liberles SD. Aversion and attraction through olfaction. Curr Biol. 2015 Feb 02; 25(3):R120-R129. PMID: 25649823; PMCID: PMC4317791.
    Citations: 66     Fields:    Translation:AnimalsCells
  29. Liberles SD. Trace amine-associated receptors: ligands, neural circuits, and behaviors. Curr Opin Neurobiol. 2015 Oct; 34:1-7. PMID: 25616211; PMCID: PMC4508243.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  30. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2014 Dec 19; 3. PMID: 25525749.
    Citations: 103     Fields:    Translation:AnimalsCells
  31. Baldwin MW, Toda Y, Nakagita T, O'Connell MJ, Klasing KC, Misaka T, Edwards SV, Liberles SD. Sensory biology. Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor. Science. 2014 Aug 22; 345(6199):929-33. PMID: 25146290.
    Citations: 54     Fields:    Translation:AnimalsCells
  32. Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13; 507(7491):238-42. PMID: 24487620.
    Citations: 275     Fields:    Translation:AnimalsCells
  33. Hussain A, Saraiva LR, Ferrero DM, Ahuja G, Krishna VS, Liberles SD, Korsching SI. High-affinity olfactory receptor for the death-associated odor cadaverine. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19579-84. PMID: 24218586.
    Citations: 65     Fields:    Translation:Animals
  34. Ferrero DM, Moeller LM, Osakada T, Horio N, Li Q, Roy DS, Cichy A, Spehr M, Touhara K, Liberles SD. A juvenile mouse pheromone inhibits sexual behaviour through the vomeronasal system. Nature. 2013 Oct 17; 502(7471):368-71. PMID: 24089208.
    Citations: 66     Fields:    Translation:AnimalsCells
  35. Liberles SD. Mammalian pheromones. Annu Rev Physiol. 2014; 76:151-75. PMID: 23988175.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  36. Ferrero DM, Liberles SD. Animal behavior: shifting neural circuits with sex hormones. Curr Biol. 2013 Jul 22; 23(14):R621-3. PMID: 23885881.
    Citations:    Fields:    Translation:AnimalsCells
  37. Li Q, Korzan WJ, Ferrero DM, Chang RB, Roy DS, Buchi M, Lemon JK, Kaur AW, Stowers L, Fendt M, Liberles SD. Synchronous evolution of an odor biosynthesis pathway and behavioral response. Curr Biol. 2013 Jan 07; 23(1):11-20. PMID: 23177478.
    Citations: 73     Fields:    Translation:Animals
  38. Johnson MA, Tsai L, Roy DS, Valenzuela DH, Mosley C, Magklara A, Lomvardas S, Liberles SD, Barnea G. Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13410-5. PMID: 22837392.
    Citations: 49     Fields:    Translation:AnimalsCells
  39. Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD. Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity. ACS Chem Biol. 2012 Jul 20; 7(7):1184-9. PMID: 22545963.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  40. Ferrero DM, Lemon JK, Fluegge D, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD. Detection and avoidance of a carnivore odor by prey. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11235-40. PMID: 21690383.
    Citations: 130     Fields:    Translation:AnimalsCells
  41. Ferrero DM, Liberles SD. The secret codes of mammalian scents. Wiley Interdiscip Rev Syst Biol Med. 2010 Jan-Feb; 2(1):23-33. PMID: 20836008.
    Citations: 15     Fields:    Translation:HumansAnimals
  42. Liberles SD. Trace amine-associated receptors are olfactory receptors in vertebrates. Ann N Y Acad Sci. 2009 Jul; 1170:168-72. PMID: 19686131.
    Citations: 31     Fields:    Translation:HumansAnimals
  43. Liberles SD, Horowitz LF, Kuang D, Contos JJ, Wilson KL, Siltberg-Liberles J, Liberles DA, Buck LB. Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9842-7. PMID: 19497865.
    Citations: 107     Fields:    Translation:AnimalsCells
  44. Liberles SD, Buck LB. A second class of chemosensory receptors in the olfactory epithelium. Nature. 2006 Aug 10; 442(7103):645-50. PMID: 16878137.
    Citations: 272     Fields:    Translation:HumansAnimalsCells
  45. Montmayeur JP, Liberles SD, Matsunami H, Buck LB. A candidate taste receptor gene near a sweet taste locus. Nat Neurosci. 2001 May; 4(5):492-8. PMID: 11319557.
    Citations: 130     Fields:    Translation:AnimalsCells
  46. Liberles SD, Schreiber SL. Apoptosis-inducing natural products found in utero during murine pregnancy. Chem Biol. 2000 May; 7(5):365-72. PMID: 10801475.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  47. Borchardt A, Liberles SD, Biggar SR, Crabtree GR, Schreiber SL. Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale. Chem Biol. 1997 Dec; 4(12):961-8. PMID: 9427663.
    Citations: 13     Fields:    Translation:Animals
  48. Liberles SD, Diver ST, Austin DJ, Schreiber SL. Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7825-30. PMID: 9223271; PMCID: PMC21513.
    Citations: 60     Fields:    Translation:AnimalsCells
  49. Ganguly AK, Pramanik BN, Huang EC, Liberles S, Heimark L, Liu YH, Tsarbopoulos A, Doll RJ, Taveras AG, Remiszewski S, Snow ME, Wang YS, Vibulbhan B, Cesarz D, Brown JE, del Rosario J, James L, Kirschmeier P, Girijavallabhan V. Detection and structural characterization of ras oncoprotein-inhibitors complexes by electrospray mass spectrometry. Bioorg Med Chem. 1997 May; 5(5):817-20. PMID: 9208093.
    Citations: 9     Fields:    Translation:Cells
  50. Taveras AG, Remiszewski SW, Doll RJ, Cesarz D, Huang EC, Kirschmeier P, Pramanik BN, Snow ME, Wang YS, del Rosario JD, Vibulbhan B, Bauer BB, Brown JE, Carr D, Catino J, Evans CA, Girijavallabhan V, Heimark L, James L, Liberles S, Nash C, Perkins L, Senior MM, Tsarbopoulos A, Webber SE, et al. Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex. Bioorg Med Chem. 1997 Jan; 5(1):125-33. PMID: 9043664.
    Citations: 37     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.