Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

James Francis Gusella, Ph.D.

Co-Author

This page shows the publications co-authored by James Gusella and Vanessa Wheeler.
Connection Strength

1.557
  1. Genetic modifiers of Huntington disease differentially influence motor and cognitive domains. Am J Hum Genet. 2022 Mar 18.
    View in: PubMed
    Score: 0.248
  2. A modifier of Huntington's disease onset at the MLH1 locus. Hum Mol Genet. 2017 10 01; 26(19):3859-3867.
    View in: PubMed
    Score: 0.182
  3. A novel approach to investigate tissue-specific trinucleotide repeat instability. BMC Syst Biol. 2010 Mar 19; 4:29.
    View in: PubMed
    Score: 0.108
  4. Factors associated with HD CAG repeat instability in Huntington disease. J Med Genet. 2007 Nov; 44(11):695-701.
    View in: PubMed
    Score: 0.090
  5. Huntington's disease. Neuromolecular Med. 2003; 4(1-2):7-20.
    View in: PubMed
    Score: 0.066
  6. Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice. Hum Mol Genet. 2002 Mar 15; 11(6):633-40.
    View in: PubMed
    Score: 0.062
  7. Huntington's Disease Pathogenesis: Two Sequential Components. J Huntingtons Dis. 2021; 10(1):35-51.
    View in: PubMed
    Score: 0.057
  8. Association Analysis of Chromosome X to Identify Genetic Modifiers of Huntington's Disease. J Huntingtons Dis. 2021; 10(3):367-375.
    View in: PubMed
    Score: 0.057
  9. Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out. Hum Mol Genet. 2020 11 04; 29(18):3044-3053.
    View in: PubMed
    Score: 0.056
  10. Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice. Hum Mol Genet. 2000 Mar 01; 9(4):503-13.
    View in: PubMed
    Score: 0.054
  11. Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington's Disease. Biol Psychiatry. 2020 05 01; 87(9):857-865.
    View in: PubMed
    Score: 0.053
  12. Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse. Hum Mol Genet. 1999 Jan; 8(1):115-22.
    View in: PubMed
    Score: 0.050
  13. Population-specific genetic modification of Huntington's disease in Venezuela. PLoS Genet. 2018 05; 14(5):e1007274.
    View in: PubMed
    Score: 0.048
  14. Haplotype-based stratification of Huntington's disease. Eur J Hum Genet. 2017 11; 25(11):1202-1209.
    View in: PubMed
    Score: 0.045
  15. High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds. Hum Mol Genet. 2017 03 01; 26(5):913-922.
    View in: PubMed
    Score: 0.044
  16. Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice. Nat Biotechnol. 2016 08; 34(8):838-44.
    View in: PubMed
    Score: 0.042
  17. The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease. J Huntingtons Dis. 2015; 4(3):279-84.
    View in: PubMed
    Score: 0.038
  18. Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families. Am J Hum Genet. 2014 Jun 05; 94(6):870-83.
    View in: PubMed
    Score: 0.036
  19. HD CAGnome: a search tool for huntingtin CAG repeat length-correlated genes. PLoS One. 2014; 9(4):e95556.
    View in: PubMed
    Score: 0.036
  20. Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy. Hum Mol Genet. 2013 Aug 15; 22(16):3227-38.
    View in: PubMed
    Score: 0.033
  21. Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative. Hum Mol Genet. 2011 Nov 01; 20(21):4258-67.
    View in: PubMed
    Score: 0.030
  22. Huntingtin facilitates polycomb repressive complex 2. Hum Mol Genet. 2010 Feb 15; 19(4):573-83.
    View in: PubMed
    Score: 0.026
  23. Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG). Am J Med Genet A. 2009 Jul; 149A(7):1375-81.
    View in: PubMed
    Score: 0.026
  24. Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. BMC Med Genet. 2006 Aug 17; 7:71.
    View in: PubMed
    Score: 0.021
  25. A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study. Am J Hum Genet. 2003 Sep; 73(3):682-7.
    View in: PubMed
    Score: 0.017
  26. Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice. Hum Mol Genet. 2003 Mar 01; 12(5):497-508.
    View in: PubMed
    Score: 0.017
  27. Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice. Hum Mol Genet. 2002 Sep 15; 11(19):2233-41.
    View in: PubMed
    Score: 0.016
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.