Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Basil Pawlyk, M.Sc.

Title
Institution
Department
Address
Phone

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Greenwald SH, Brown EE, Scandura MJ, Hennessey E, Farmer R, Pawlyk BS, Xiao R, Vandenberghe LH, Pierce EA. Gene Therapy Preserves Retinal Structure and Function in a Mouse Model of NMNAT1-Associated Retinal Degeneration. Mol Ther Methods Clin Dev. 2020 Sep 11; 18:582-594. PMID: 32775493.
    Citations:    
  2. Pendse ND, Lamas V, Pawlyk BS, Maeder ML, Chen ZY, Pierce EA, Liu Q. In Vivo Assessment of Potential Therapeutic Approaches for USH2A-Associated Diseases. Adv Exp Med Biol. 2019; 1185:91-96. PMID: 31884594.
    Citations:    
  3. Mantopoulos D, Bouzika P, Tsakris A, Pawlyk BS, Sandberg MA, Miller JW, Rizzo Iii JF, Vavvas DG, Cestari DM. An Experimental Animal Model of Photodynamic Optic Nerve Head Injury (PONHI). Curr Eye Res. 2016 11; 41(11):1498-1506. PMID: 27158920.
    Citations:    Fields:    Translation:AnimalsCells
  4. Pawlyk BS, Bulgakov OV, Sun X, Adamian M, Shu X, Smith AJ, Berson EL, Ali RR, Khani S, Wright AF, Sandberg MA, Li T. Photoreceptor rescue by an abbreviated human RPGR gene in a murine model of X-linked retinitis pigmentosa. Gene Ther. 2016 Feb; 23(2):196-204. PMID: 26348595.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  5. Andzelm MM, Cherry TJ, Harmin DA, Boeke AC, Lee C, Hemberg M, Pawlyk B, Malik AN, Flavell SW, Sandberg MA, Raviola E, Greenberg ME. MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers. Neuron. 2015 Apr 08; 86(1):247-63. PMID: 25801704.
    Citations: 15     Fields:    Translation:AnimalsCells
  6. Samuel MA, Voinescu PE, Lilley BN, de Cabo R, Foretz M, Viollet B, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JR. LKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci. 2014 Sep; 17(9):1190-7. PMID: 25086610.
    Citations: 21     Fields:    Translation:AnimalsCells
  7. Wiggs JL, Pawlyk B, Connolly E, Adamian M, Miller JW, Pasquale LR, Haddadin RI, Grosskreutz CL, Rhee DJ, Li T. Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1). Invest Ophthalmol Vis Sci. 2014 Feb 10; 55(2):856-64. PMID: 24425853.
    Citations: 11     Fields:    Translation:Animals
  8. Thanos A, Morizane Y, Murakami Y, Giani A, Mantopoulos D, Kayama M, Roh MI, Michaud N, Pawlyk B, Sandberg M, Young LH, Miller JW, Vavvas DG. Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse. Am J Pathol. 2012 May; 180(5):1917-27. PMID: 22429967.
    Citations: 15     Fields:    Translation:AnimalsCells
  9. Pawlyk BS, Bulgakov OV, Liu X, Xu X, Adamian M, Sun X, Khani SC, Berson EL, Sandberg MA, Li T. Replacement gene therapy with a human RPGRIP1 sequence slows photoreceptor degeneration in a murine model of Leber congenital amaurosis. Hum Gene Ther. 2010 Aug; 21(8):993-1004. PMID: 20384479.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  10. Yang J, Liu X, Zhao Y, Adamian M, Pawlyk B, Sun X, McMillan DR, Liberman MC, Li T. Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genet. 2010 May 20; 6(5):e1000955. PMID: 20502675.
    Citations: 43     Fields:    Translation:Animals
  11. Liu X, Pawlyk BS, Adamian M, Olshevskaya EV, Dizhoor AM, Makino CL, Li T. Increased light exposure alleviates one form of photoreceptor degeneration marked by elevated calcium in the dark. PLoS One. 2009 Dec 24; 4(12):e8438. PMID: 20041177.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Sun X, Pawlyk B, Xu X, Liu X, Bulgakov OV, Adamian M, Sandberg MA, Khani SC, Tan MH, Smith AJ, Ali RR, Li T. Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations. Gene Ther. 2010 Jan; 17(1):117-31. PMID: 19710705.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  13. Tan MH, Smith AJ, Pawlyk B, Xu X, Liu X, Bainbridge JB, Basche M, McIntosh J, Tran HV, Nathwani A, Li T, Ali RR. Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors. Hum Mol Genet. 2009 Jun 15; 18(12):2099-114. PMID: 19299492.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  14. Khani SC, Pawlyk BS, Bulgakov OV, Kasperek E, Young JE, Adamian M, Sun X, Smith AJ, Ali RR, Li T. AAV-mediated expression targeting of rod and cone photoreceptors with a human rhodopsin kinase promoter. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):3954-61. PMID: 17724172.
    Citations: 50     Fields:    Translation:AnimalsCells
  15. Storch KF, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, Weitz CJ. Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information. Cell. 2007 Aug 24; 130(4):730-741. PMID: 17719549.
    Citations: 130     Fields:    Translation:Animals
  16. Denny CA, Alroy J, Pawlyk BS, Sandberg MA, d'Azzo A, Seyfried TN. Neurochemical, morphological, and neurophysiological abnormalities in retinas of Sandhoff and GM1 gangliosidosis mice. J Neurochem. 2007 Jun; 101(5):1294-302. PMID: 17442056.
    Citations: 11     Fields:    Translation:Animals
  17. Yang J, Pawlyk B, Wen XH, Adamian M, Soloviev M, Michaud N, Zhao Y, Sandberg MA, Makino CL, Li T. Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Hum Mol Genet. 2007 May 01; 16(9):1017-29. PMID: 17341488.
    Citations: 11     Fields:    Translation:AnimalsCells
  18. Liu X, Bulgakov OV, Darrow KN, Pawlyk B, Adamian M, Liberman MC, Li T. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4413-8. PMID: 17360538.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  19. Storch KF, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, Weitz CJ. Physiological importance of a circadian clock outside the suprachiasmatic nucleus. Cold Spring Harb Symp Quant Biol. 2007; 72:307-18. PMID: 18419288.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Adamian M, Pawlyk BS, Hong DH, Berson EL. Rod and cone opsin mislocalization in an autopsy eye from a carrier of X-linked retinitis pigmentosa with a Gly436Asp mutation in the RPGR gene. Am J Ophthalmol. 2006 Sep; 142(3):515-8. PMID: 16935610.
    Citations: 13     Fields:    Translation:HumansCells
  21. Makino CL, Wen XH, Michaud N, Peshenko IV, Pawlyk B, Brush RS, Soloviev M, Liu X, Woodruff ML, Calvert PD, Savchenko AB, Anderson RE, Fain GL, Li T, Sandberg MA, Dizhoor AM. Effects of low AIPL1 expression on phototransduction in rods. Invest Ophthalmol Vis Sci. 2006 May; 47(5):2185-94. PMID: 16639031.
    Citations: 10     Fields:    Translation:AnimalsCells
  22. Liu X, Zhao Y, Pawlyk B, Damaser M, Li T. Failure of elastic fiber homeostasis leads to pelvic floor disorders. Am J Pathol. 2006 Feb; 168(2):519-28. PMID: 16436666.
    Citations: 44     Fields:    Translation:Animals
  23. Landis MW, Pawlyk BS, Li T, Sicinski P, Hinds PW. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell. 2006 Jan; 9(1):13-22. PMID: 16413468.
    Citations: 112     Fields:    Translation:AnimalsCells
  24. Pawlyk BS, Smith AJ, Buch PK, Adamian M, Hong DH, Sandberg MA, Ali RR, Li T. Gene replacement therapy rescues photoreceptor degeneration in a murine model of Leber congenital amaurosis lacking RPGRIP. Invest Ophthalmol Vis Sci. 2005 Sep; 46(9):3039-45. PMID: 16123399.
    Citations: 48     Fields:    Translation:AnimalsCells
  25. Yang J, Gao J, Adamian M, Wen XH, Pawlyk B, Zhang L, Sanderson MJ, Zuo J, Makino CL, Li T. The ciliary rootlet maintains long-term stability of sensory cilia. Mol Cell Biol. 2005 May; 25(10):4129-37. PMID: 15870283.
    Citations: 48     Fields:    Translation:AnimalsCells
  26. Hong DH, Pawlyk BS, Adamian M, Sandberg MA, Li T. A single, abbreviated RPGR-ORF15 variant reconstitutes RPGR function in vivo. Invest Ophthalmol Vis Sci. 2005 Feb; 46(2):435-41. PMID: 15671266.
    Citations: 28     Fields:    Translation:AnimalsCells
  27. Carthon BC, Neumann CA, Das M, Pawlyk B, Li T, Geng Y, Sicinski P. Genetic replacement of cyclin D1 function in mouse development by cyclin D2. Mol Cell Biol. 2005 Feb; 25(3):1081-8. PMID: 15657434.
    Citations: 23     Fields:    Translation:Animals
  28. Liu X, Bulgakov OV, Wen XH, Woodruff ML, Pawlyk B, Yang J, Fain GL, Sandberg MA, Makino CL, Li T. AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase. Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38):13903-8. PMID: 15365173.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  29. Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J, Li T. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet. 2004 Feb; 36(2):178-82. PMID: 14745449.
    Citations: 180     Fields:    Translation:AnimalsCells
  30. Hong DH, Pawlyk BS, Adamian M, Li T. Dominant, gain-of-function mutant produced by truncation of RPGR. Invest Ophthalmol Vis Sci. 2004 Jan; 45(1):36-41. PMID: 14691151.
    Citations: 21     Fields:    Translation:AnimalsCells
  31. Marneros AG, Keene DR, Hansen U, Fukai N, Moulton K, Goletz PL, Moiseyev G, Pawlyk BS, Halfter W, Dong S, Shibata M, Li T, Crouch RK, Bruckner P, Olsen BR. Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J. 2004 Jan 14; 23(1):89-99. PMID: 14685281.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  32. Hong DH, Pawlyk B, Sokolov M, Strissel KJ, Yang J, Tulloch B, Wright AF, Arshavsky VY, Li T. RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2413-21. PMID: 12766038.
    Citations: 72     Fields:    Translation:AnimalsCells
  33. Zhao Y, Hong DH, Pawlyk B, Yue G, Adamian M, Grynberg M, Godzik A, Li T. The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):3965-70. PMID: 12651948.
    Citations: 83     Fields:    Translation:AnimalsCells
  34. Pawlyk BS, Li T, Scimeca MS, Sandberg MA, Berson EL. Absence of photoreceptor rescue with D-cis-diltiazem in the rd mouse. Invest Ophthalmol Vis Sci. 2002 Jun; 43(6):1912-5. PMID: 12036998.
    Citations: 17     Fields:    Translation:AnimalsCells
  35. Hagstrom SA, Adamian M, Scimeca M, Pawlyk BS, Yue G, Li T. A role for the Tubby-like protein 1 in rhodopsin transport. Invest Ophthalmol Vis Sci. 2001 Aug; 42(9):1955-62. PMID: 11481257.
    Citations: 42     Fields:    Translation:AnimalsCells
  36. Lu C, Peng YW, Shang J, Pawlyk BS, Yu F, Li T. The mammalian retinal degeneration B2 gene is not required for photoreceptor function and survival. Neuroscience. 2001; 107(1):35-41. PMID: 11744244.
    Citations: 14     Fields:    Translation:AnimalsCells
  37. Ciulla TA, Pawlyk BS, Harris A, Oberoi A, Miller JW, Sandberg MA. Endothelin-1-mediated retinal artery vasospasm and the rabbit electroretinogram. J Ocul Pharmacol Ther. 2000 Aug; 16(4):393-8. PMID: 10977135.
    Citations: 1     Fields:    Translation:Animals
  38. Hong DH, Pawlyk BS, Shang J, Sandberg MA, Berson EL, Li T. A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3649-54. PMID: 10725384.
    Citations: 81     Fields:    Translation:AnimalsCells
  39. Sandberg MA, Pawlyk BS, Berson EL. Acuity recovery and cone pigment regeneration after a bleach in patients with retinitis pigmentosa and rhodopsin mutations. Invest Ophthalmol Vis Sci. 1999 Sep; 40(10):2457-61. PMID: 10476820.
    Citations: 4     Fields:    Translation:HumansCells
  40. Li T, Sandberg MA, Pawlyk BS, Rosner B, Hayes KC, Dryja TP, Berson EL. Effect of vitamin A supplementation on rhodopsin mutants threonine-17 --> methionine and proline-347 --> serine in transgenic mice and in cell cultures. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11933-8. PMID: 9751768.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  41. Sandberg MA, Pawlyk BS, Dan J, Arnaud B, Dryja TP, Berson EL. Rod and cone function in the Nougaret form of stationary night blindness. Arch Ophthalmol. 1998 Jul; 116(7):867-72. PMID: 9682699.
    Citations: 9     Fields:    Translation:HumansCells
  42. Tang M, Pawlyk BS, Kosaras B, Berson EL, Sidman RL. ERG abnormalities in relation to histopathologic findings in vitiligo mutant mice. Exp Eye Res. 1997 Aug; 65(2):215-22. PMID: 9268589.
    Citations: 4     Fields:    Translation:AnimalsCells
  43. Sandberg MA, Pawlyk BS, Berson EL. Isolation of focal rod electroretinograms from the dark-adapted human eye. Invest Ophthalmol Vis Sci. 1996 Apr; 37(5):930-4. PMID: 8603878.
    Citations:    Fields:    Translation:HumansCells
  44. Olsson JE, Gordon JW, Pawlyk BS, Roof D, Hayes A, Molday RS, Mukai S, Cowley GS, Berson EL, Dryja TP. Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron. 1992 Nov; 9(5):815-30. PMID: 1418997.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  45. Pawlyk BS, Sandberg MA, Berson EL. Effects of IBMX on the rod ERG of the isolated perfused cat eye: antagonism with light, calcium or L-cis-diltiazem. Vision Res. 1991; 31(7-8):1093-7. PMID: 1716388.
    Citations: 4     Fields:    Translation:AnimalsCells
  46. Sandberg MA, Pawlyk BS, Crane WG, Berson EL. Diurnal rhythm in the electroretinogram of the Royal College of Surgeons (RCS) pigmented rat. Exp Eye Res. 1988 Jun; 46(6):929-36. PMID: 3197761.
    Citations: 3     Fields:    Translation:AnimalsCells
  47. Sandberg MA, Pawlyk BS, Crane WG, Schmidt SY, Berson EL. Effects of IBMX on the ERG of the isolated perfused cat eye. Vision Res. 1987; 27(9):1421-30. PMID: 2451348.
    Citations: 6     Fields:    Translation:AnimalsCells
  48. Sandberg MA, Pawlyk BS, Berson EL. Electroretinogram (ERG) sensitivity and phagosome frequency in the normal pigmented rat. Exp Eye Res. 1986 Nov; 43(5):781-9. PMID: 3803462.
    Citations: 4     Fields:    Translation:AnimalsCells
  49. Sandberg MA, Pawlyk BS, Berson EL. Full-field electroretinograms in miniature poodles with progressive rod-cone degeneration. Invest Ophthalmol Vis Sci. 1986 Jul; 27(7):1179-84. PMID: 3721798.
    Citations: 3     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Pawlyk's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (264)
Explore
_
Co-Authors (26)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.