Harvard Catalyst Profiles

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John Joseph Mekalanos, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. U19AI109764 (KASPER, DENNIS L.) Mar 1, 2014 - Feb 28, 2019
    NIH/NIAID
    Innovative Platforms for Antimicrobial Therapy and Vaccine Development
    Role: Co-Principal Investigator
  2. R01AI070963 (MEKALANOS, JOHN JOSEPH) Sep 15, 2007 - Jul 31, 2012
    NIH/NIAID
    Genetic and Ecological Factors in Transmissibility and Epidemic Cycle of Cholera
    Role: Principal Investigator
  3. U54AI057159 (KASPER, DENNIS L.) Sep 4, 2003 - Feb 29, 2008
    NIH/NIAID
    New England Regional Center of Excellence in Biodefense and Emerging Infectious D
    Role: Co-Principal Investigator
  4. R01GM068851 (MEKALANOS, JOHN JOSEPH) Sep 1, 2003 - Jun 30, 2011
    NIH/NIGMS
    Phages and Genomic Variation in Vibrio Cholerae Evolution
    Role: Principal Investigator
  5. T32AI007410 (MEKALANOS, JOHN J) Sep 30, 1992 - Aug 31, 2002
    NIH/NIAID
    MECHANISMS IN MICROBIAL PATHOGENESIS
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. 2020 Jul 09; 182(1):38-49.e17. PMID: 32544385.
    Citations:    
  2. Robins WP, Mekalanos JJ. Protein covariance networks reveal interactions important to the emergence of SARS coronaviruses as human pathogens. bioRxiv. 2020 Jun 11. PMID: 32577639.
    Citations:    
  3. Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):723-733.e6. PMID: 31932164.
    Citations:    
  4. Zheng W, Zhao W, Wu M, Song X, Caro F, Sun X, Gazzaniga F, Stefanetti G, Oh S, Mekalanos JJ, Kasper DL. Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature. 2020 01; 577(7791):543-548. PMID: 31915378.
    Citations:    
  5. Cartee RT, Thanawastien A, Griffin Iv TJ, Mekalanos JJ, Bart S, Killeen KP. A phase 1 randomized safety, reactogenicity, and immunogenicity study of Typhax: A novel protein capsular matrix vaccine candidate for the prevention of typhoid fever. PLoS Negl Trop Dis. 2020 01; 14(1):e0007912. PMID: 31905228.
    Citations:    
  6. Liang X, Kamal F, Pei TT, Xu P, Mekalanos JJ, Dong TG. An onboard checking mechanism ensures effector delivery of the type VI secretion system in Vibrio cholerae. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):23292-23298. PMID: 31659021.
    Citations:    
  7. Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ, Oliver A, Hauser AR. Long-term Persistence of an Extensively Drug Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center. Clin Infect Dis. 2019 Oct 04. PMID: 31583403.
    Citations:    
  8. Caro F, Place NM, Mekalanos JJ. Analysis of lipoprotein transport depletion in Vibrio cholerae using CRISPRi. Proc Natl Acad Sci U S A. 2019 08 20; 116(34):17013-17022. PMID: 31371515.
    Citations:    
  9. Rivera-Chávez F, Mekalanos JJ. Cholera toxin promotes pathogen acquisition of host-derived nutrients. Nature. 2019 08; 572(7768):244-248. PMID: 31367037.
    Citations:    
  10. Bachta KER, Ozer EA, Pandit A, Marty FM, Mekalanos JJ, Hauser AR. Draft Genome Sequence of Pseudomonas aeruginosa Strain BWH047, a Sequence Type 235 Multidrug-Resistant Clinical Isolate Expressing High Levels of Colistin Resistance. Microbiol Resour Announc. 2019 Jul 18; 8(29). PMID: 31320415.
    Citations:    
  11. Griffin TJ, Thanawastien A, Cartee RT, Mekalanos JJ, Killeen KP. In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate. Hum Vaccin Immunother. 2019; 15(6):1310-1316. PMID: 31021700.
    Citations:    
  12. Ji X, Zou J, Peng H, Stolle AS, Xie R, Zhang H, Peng B, Mekalanos JJ, Zheng J. Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9578-9585. PMID: 31004054.
    Citations:    
  13. Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ. Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 2019 03; 567(7747):194-199. PMID: 30787435.
    Citations:    
  14. Cabello FC, Cohen SN, Curtiss R, Dougan G, van Embden J, Finlay BB, Heffron F, Helinski D, Hull R, Hull S, Isberg R, Kopecko DJ, Levy S, Mekalanos J, Ortiz JM, Rappuoli R, Roberts MC, So M, Timmis KN. Farewell Stan Stanley Falkow: 1934-2018. Environ Microbiol. 2018 Jul; 20(7):2322-2333. PMID: 30146753.
    Citations:    Fields:    
  15. Toska J, Ho BT, Mekalanos JJ. Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):7997-8002. PMID: 30021850.
    Citations:    Fields:    Translation:Cells
  16. Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 07 12; 174(2):300-311.e11. PMID: 30007416.
    Citations: 1     Fields:    
  17. Kamareddine L, Robins WP, Berkey CD, Mekalanos JJ, Watnick PI. The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. Cell Metab. 2018 09 04; 28(3):449-462.e5. PMID: 29937377.
    Citations: 2     Fields:    
  18. Hubbard TP, Billings G, Dörr T, Sit B, Warr AR, Kuehl CJ, Kim M, Delgado F, Mekalanos JJ, Lewnard JA, Waldor MK. A live vaccine rapidly protects against cholera in an infant rabbit model. Sci Transl Med. 2018 06 13; 10(445). PMID: 29899024.
    Citations: 2     Fields:    
  19. Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC. Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6709-6714. PMID: 29891673.
    Citations: 1     Fields:    Translation:Cells
  20. LaPorte JP, Spinard EJ, Gomez-Chiarri M, Rowley DC, Mekalanos JJ, Nelson DR. Draft Genome Sequence of Bowmanella denitrificans JL63, a Bacterium Isolated from Whiteleg Shrimp (Litopenaeus vannamei) That Can Inhibit the Growth of Vibrio parahaemolyticus. Genome Announc. 2018 Apr 05; 6(14). PMID: 29622614.
    Citations:    
  21. Fu Y, Ho BT, Mekalanos JJ. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell Host Microbe. 2018 Feb 14; 23(2):274-281.e2. PMID: 29398650.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Zhao W, Caro F, Robins W, Mekalanos JJ. Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence. Science. 2018 01 12; 359(6372):210-213. PMID: 29326272.
    Citations: 5     Fields:    Translation:AnimalsCells
  23. Ho BT, Fu Y, Dong TG, Mekalanos JJ. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci U S A. 2017 08 29; 114(35):9427-9432. PMID: 28808000.
    Citations: 1     Fields:    Translation:Cells
  24. Kongrueng J, Mitraparp-Arthorn P, Bangpanwimon K, Robins W, Vuddhakul V, Mekalanos J. Isolation of Bdellovibrio and like organisms and potential to reduce acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus. Dis Aquat Organ. 2017 05 11; 124(3):223-232. PMID: 28492178.
    Citations: 2     Fields:    Translation:AnimalsCells
  25. Hoque MM, Naser IB, Bari SM, Zhu J, Mekalanos JJ, Faruque SM. Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages. Sci Rep. 2016 11 28; 6:37956. PMID: 27892495.
    Citations: 5     Fields:    Translation:AnimalsCells
  26. Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ. SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. 2016 09 29; 537(7622):634-638. PMID: 27525505.
    Citations: 47     Fields:    Translation:Cells
  27. Del Tordello E, Danilchanka O, McCluskey AJ, Mekalanos JJ. Type VI secretion system sheaths as nanoparticles for antigen display. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3042-7. PMID: 26929342.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
  28. Skurnik D, Clermont O, Guillard T, Launay A, Danilchanka O, Pons S, Diancourt L, Lebreton F, Kadlec K, Roux D, Jiang D, Dion S, Aschard H, Denamur M, Cywes-Bentley C, Schwarz S, Tenaillon O, Andremont A, Picard B, Mekalanos J, Brisse S, Denamur E. Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans. Mol Biol Evol. 2016 Apr; 33(4):898-914. PMID: 26613786.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  29. Roux D, Danilchanka O, Guillard T, Cattoir V, Aschard H, Fu Y, Angoulvant F, Messika J, Ricard JD, Mekalanos JJ, Lory S, Pier GB, Skurnik D. Fitness cost of antibiotic susceptibility during bacterial infection. Sci Transl Med. 2015 Jul 22; 7(297):297ra114. PMID: 26203082.
    Citations: 20     Fields:    Translation:AnimalsCells
  30. Altindis E, Dong T, Catalano C, Mekalanos J. Secretome analysis of Vibrio cholerae type VI secretion system reveals a new effector-immunity pair. mBio. 2015 Mar 10; 6(2):e00075. PMID: 25759499.
    Citations: 17     Fields:    Translation:Cells
  31. Thanawastien A, Cartee RT, Griffin TJ, Killeen KP, Mekalanos JJ. Conjugate-like immunogens produced as protein capsular matrix vaccines. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1143-51. PMID: 25699685.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  32. Dong TG, Dong S, Catalano C, Moore R, Liang X, Mekalanos JJ. Generation of reactive oxygen species by lethal attacks from competing microbes. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2181-6. PMID: 25646446.
    Citations: 21     Fields:    Translation:HumansCells
  33. Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Cell Host Microbe. 2014 Nov 12; 16(5):592-604. PMID: 25525791.
    Citations: 18     Fields:    Translation:AnimalsCells
  34. Suzuki M, Danilchanka O, Mekalanos JJ. Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases. Cell Host Microbe. 2014 Nov 12; 16(5):581-91. PMID: 25450857.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  35. Kamruzzaman M, Robins WP, Bari SM, Nahar S, Mekalanos JJ, Faruque SM. RS1 satellite phage promotes diversity of toxigenic Vibrio cholerae by driving CTX prophage loss and elimination of lysogenic immunity. Infect Immun. 2014 Sep; 82(9):3636-43. PMID: 24935981.
    Citations: 4     Fields:    Translation:AnimalsCells
  36. Vercruysse M, Köhrer C, Davies BW, Arnold MF, Mekalanos JJ, RajBhandary UL, Walker GC. The highly conserved bacterial RNase YbeY is essential in Vibrio cholerae, playing a critical role in virulence, stress regulation, and RNA processing. PLoS Pathog. 2014 Jun; 10(6):e1004175. PMID: 24901994.
    Citations: 12     Fields:    Translation:AnimalsCells
  37. Fu Y, Mekalanos JJ. Infant Rabbit Colonization Competition Assays. Bio Protoc. 2014 Jun 05; 4(11). PMID: 29170743.
    Citations:    
  38. Altindis E, Fu Y, Mekalanos JJ. Proteomic analysis of Vibrio cholerae outer membrane vesicles. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):E1548-56. PMID: 24706774.
    Citations: 30     Fields:    Translation:Cells
  39. Yingkajorn M, Sermwitayawong N, Palittapongarnpimp P, Nishibuchi M, Robins WP, Mekalanos JJ, Vuddhakul V. Vibrio parahaemolyticus and its specific bacteriophages as an indicator in cockles (Anadara granosa) for the risk of V. parahaemolyticus infection in Southern Thailand. Microb Ecol. 2014 May; 67(4):849-56. PMID: 24682339.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  40. Robins WP, Mekalanos JJ. Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen. Curr Top Microbiol Immunol. 2014; 379:211-29. PMID: 24590676.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
  41. Ho BT, Dong TG, Mekalanos JJ. A view to a kill: the bacterial type VI secretion system. Cell Host Microbe. 2014 Jan 15; 15(1):9-21. PMID: 24332978.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  42. Fu Y, Waldor MK, Mekalanos JJ. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host Microbe. 2013 Dec 11; 14(6):652-63. PMID: 24331463.
    Citations: 63     Fields:    Translation:AnimalsCells
  43. Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB. Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20747-52. PMID: 24248354.
    Citations: 22     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  44. Ho BT, Basler M, Mekalanos JJ. Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer. Science. 2013 Oct 11; 342(6155):250-3. PMID: 24115441.
    Citations: 22     Fields:    Translation:Cells
  45. Mekalanos JJ. Vaccine economics: what price human life? Sci Transl Med. 2013 Sep 25; 5(204):204ed16. PMID: 24068732.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  46. Danilchanka O, Mekalanos JJ. Cyclic dinucleotides and the innate immune response. Cell. 2013 Aug 29; 154(5):962-970. PMID: 23993090.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  47. Shneider MM, Buth SA, Ho BT, Basler M, Mekalanos JJ, Leiman PG. PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature. 2013 Aug 15; 500(7462):350-353. PMID: 23925114.
    Citations: 96     Fields:    Translation:Cells
  48. Bari SM, Roky MK, Mohiuddin M, Kamruzzaman M, Mekalanos JJ, Faruque SM. Quorum-sensing autoinducers resuscitate dormant Vibrio cholerae in environmental water samples. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9926-31. PMID: 23716683.
    Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
  49. Basler M, Ho BT, Mekalanos JJ. Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell. 2013 Feb 14; 152(4):884-94. PMID: 23415234.
    Citations: 101     Fields:    Translation:Cells
  50. Robins WP, Faruque SM, Mekalanos JJ. Coupling mutagenesis and parallel deep sequencing to probe essential residues in a genome or gene. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):E848-57. PMID: 23401533.
    Citations: 8     Fields:    Translation:Cells
  51. Dong TG, Ho BT, Yoder-Himes DR, Mekalanos JJ. Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae. Proc Natl Acad Sci U S A. 2013 Feb 12; 110(7):2623-8. PMID: 23362380.
    Citations: 74     Fields:    Translation:AnimalsCells
  52. Faruque SM, Mekalanos JJ. Phage-bacterial interactions in the evolution of toxigenic Vibrio cholerae. Virulence. 2012 Nov 15; 3(7):556-65. PMID: 23076327.
    Citations: 20     Fields:    Translation:HumansCells
  53. Mekalanos JJ, Robins W, Ussery DW, Davis BM, Schadt E, Waldor MK. Non-O1 Vibrio cholerae unlinked to cholera in Haiti. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):E3206; author reply E3207. PMID: 23035253.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
  54. Bogard RW, Davies BW, Mekalanos JJ. MetR-regulated Vibrio cholerae metabolism is required for virulence. mBio. 2012; 3(5). PMID: 23015737.
    Citations: 8     Fields:    Translation:AnimalsCells
  55. Seed KD, Faruque SM, Mekalanos JJ, Calderwood SB, Qadri F, Camilli A. Phase variable O antigen biosynthetic genes control expression of the major protective antigen and bacteriophage receptor in Vibrio cholerae O1. PLoS Pathog. 2012 Sep; 8(9):e1002917. PMID: 23028317.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  56. Basler M, Mekalanos JJ. Type 6 secretion dynamics within and between bacterial cells. Science. 2012 Aug 17; 337(6096):815. PMID: 22767897.
    Citations: 67     Fields:    Translation:Cells
  57. Bashir A, Klammer A, Robins WP, Chin CS, Webster D, Paxinos E, Hsu D, Ashby M, Wang S, Peluso P, Sebra R, Sorenson J, Bullard J, Yen J, Valdovino M, Mollova E, Luong K, Lin S, LaMay B, Joshi A, Rowe L, Frace M, Tarr CL, Turnsek M, Davis BM, Kasarskis A, Mekalanos JJ, Waldor MK, Schadt EE. A hybrid approach for the automated finishing of bacterial genomes. Nat Biotechnol. 2012 Jul 01; 30(7):701-707. PMID: 22750883.
    Citations: 66     Fields:    Translation:Cells
  58. Dong TG, Mekalanos JJ. Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52. Nucleic Acids Res. 2012 Sep; 40(16):7766-75. PMID: 22723378.
    Citations: 30     Fields:    Translation:Cells
  59. Davies BW, Bogard RW, Young TS, Mekalanos JJ. Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence. Cell. 2012 Apr 13; 149(2):358-70. PMID: 22500802.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  60. Basler M, Pilhofer M, Henderson GP, Jensen GJ, Mekalanos JJ. Type VI secretion requires a dynamic contractile phage tail-like structure. Nature. 2012 Feb 26; 483(7388):182-6. PMID: 22367545.
    Citations: 159     Fields:    Translation:Cells
  61. Rattanama P, Thompson JR, Kongkerd N, Srinitiwarawong K, Vuddhakul V, Mekalanos JJ. Sigma E regulators control hemolytic activity and virulence in a shrimp pathogenic Vibrio harveyi. PLoS One. 2012; 7(2):e32523. PMID: 22384269.
    Citations: 9     Fields:    Translation:AnimalsCells
  62. Zheng J, Ho B, Mekalanos JJ. Genetic analysis of anti-amoebae and anti-bacterial activities of the type VI secretion system in Vibrio cholerae. PLoS One. 2011; 6(8):e23876. PMID: 21909372.
    Citations: 64     Fields:    Translation:AnimalsCells
  63. Mandlik A, Livny J, Robins WP, Ritchie JM, Mekalanos JJ, Waldor MK. RNA-Seq-based monitoring of infection-linked changes in Vibrio cholerae gene expression. Cell Host Microbe. 2011 Aug 18; 10(2):165-74. PMID: 21843873.
    Citations: 85     Fields:    Translation:AnimalsCells
  64. Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB. Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient. Front Microbiol. 2011; 2:162. PMID: 21863142.
    Citations: 8     
  65. Davies BW, Bogard RW, Mekalanos JJ. Mapping the regulon of Vibrio cholerae ferric uptake regulator expands its known network of gene regulation. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12467-72. PMID: 21750152.
    Citations: 32     Fields:    Translation:Cells
  66. Shin OS, Tam VC, Suzuki M, Ritchie JM, Bronson RT, Waldor MK, Mekalanos JJ. Type III secretion is essential for the rapidly fatal diarrheal disease caused by non-O1, non-O139 Vibrio cholerae. mBio. 2011; 2(3):e00106-11. PMID: 21673189.
    Citations: 28     Fields:    Translation:AnimalsCells
  67. Farmer P, Almazor CP, Bahnsen ET, Barry D, Bazile J, Bloom BR, Bose N, Brewer T, Calderwood SB, Clemens JD, Cravioto A, Eustache E, Jérôme G, Gupta N, Harris JB, Hiatt HH, Holstein C, Hotez PJ, Ivers LC, Kerry VB, Koenig SP, Larocque RC, Léandre F, Lambert W, Lyon E, Mekalanos JJ, Mukherjee JS, Oswald C, Pape JW, Gretchko Prosper A, Rabinovich R, Raymonville M, Réjouit JR, Ronan LJ, Rosenberg ML, Ryan ET, Sachs JD, Sack DA, Surena C, Suri AA, Ternier R, Waldor MK, Walton D, Weigel JL. Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care. PLoS Negl Trop Dis. 2011; 5(5):e1145. PMID: 21655350.
    Citations: 25     Fields:    Translation:HumansPHPublic Health
  68. Davies BW, Bogard RW, Dupes NM, Gerstenfeld TA, Simmons LA, Mekalanos JJ. DNA damage and reactive nitrogen species are barriers to Vibrio cholerae colonization of the infant mouse intestine. PLoS Pathog. 2011 Feb; 7(2):e1001295. PMID: 21379340.
    Citations: 21     Fields:    Translation:AnimalsCells
  69. Zahid MS, Waise Z, Kamruzzaman M, Ghosh AN, Nair GB, Khairul Bashar SA, Mekalanos JJ, Faruque SM. An experimental study of phage mediated bactericidal selection & emergence of the El Tor Vibrio cholerae. Indian J Med Res. 2011 Feb; 133:218-24. PMID: 21415498.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  70. Chin CS, Sorenson J, Harris JB, Robins WP, Charles RC, Jean-Charles RR, Bullard J, Webster DR, Kasarskis A, Peluso P, Paxinos EE, Yamaichi Y, Calderwood SB, Mekalanos JJ, Schadt EE, Waldor MK. The origin of the Haitian cholera outbreak strain. N Engl J Med. 2011 Jan 06; 364(1):33-42. PMID: 21142692.
    Citations: 234     Fields:    Translation:HumansCellsPHPublic Health
  71. Tam VC, Suzuki M, Coughlin M, Saslowsky D, Biswas K, Lencer WI, Faruque SM, Mekalanos JJ. Functional analysis of VopF activity required for colonization in Vibrio cholerae. mBio. 2010 Dec 07; 1(5). PMID: 21151774.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  72. Zheng J, Shin OS, Cameron DE, Mekalanos JJ. Quorum sensing and a global regulator TsrA control expression of type VI secretion and virulence in Vibrio cholerae. Proc Natl Acad Sci U S A. 2010 Dec 07; 107(49):21128-33. PMID: 21084635.
    Citations: 50     Fields:    Translation:AnimalsCells