Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

John Joseph Mekalanos, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. U19AI109764 (KASPER, DENNIS L.) Mar 1, 2014 - Jun 30, 2019
    NIH
    Innovative Platforms for Antimicrobial Therapy and Vaccine Development
    Role: Co-Principal Investigator
  2. R01AI070963 (MEKALANOS, JOHN JOSEPH) Sep 15, 2007 - Jul 31, 2012
    NIH
    Genetic and Ecological Factors in Transmissibility and Epidemic Cycle of Cholera
    Role: Principal Investigator
  3. U54AI057159 (KASPER, DENNIS L.) Sep 4, 2003 - Feb 28, 2015
    NIH
    New England Regional Center of Excellence in Biodefense and Emerging Infectious D
    Role: Co-Principal Investigator
  4. R01GM068851 (MEKALANOS, JOHN JOSEPH) Sep 1, 2003 - Jan 31, 2017
    NIH
    Phages and Genomic Variation in Vibrio Cholerae Evolution
    Role: Principal Investigator
  5. T32AI007410 (MEKALANOS, JOHN J) Sep 30, 1992 - Aug 31, 2002
    NIH
    MECHANISMS IN MICROBIAL PATHOGENESIS
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Manera K, Caro F, Li H, Pei TT, Hersch SJ, Mekalanos JJ, Dong TG. Sensing of intracellular Hcp levels controls T6SS expression in Vibrio cholerae. Proc Natl Acad Sci U S A. 2021 Jun 22; 118(25). PMID: 34161288.
    Citations:    Fields:    
  2. Stolle AS, Meader BT, Toska J, Mekalanos JJ. Endogenous membrane stress induces T6SS activity in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). PMID: 33443205.
    Citations: 2     Fields:    Translation:Cells
  3. Caro F, Caro JA, Place NM, Mekalanos JJ. Transcriptional Silencing by TsrA in the Evolution of Pathogenic Vibrio cholerae Biotypes. mBio. 2020 11 24; 11(6). PMID: 33234688.
    Citations:    Fields:    
  4. Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR. Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27502-27508. PMID: 33087577.
    Citations: 3     Fields:    Translation:HumansCells
  5. Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ, Oliver A, Hauser AR. Long-term Persistence of an Extensively Drug-Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center. Clin Infect Dis. 2020 09 12; 71(6):1524-1531. PMID: 31583403.
    Citations: 2     Fields:    Translation:HumansCells
  6. Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. 2020 07 09; 182(1):38-49.e17. PMID: 32544385.
    Citations: 11     Fields:    Translation:Cells
  7. Robins WP, Mekalanos JJ. Protein covariance networks reveal interactions important to the emergence of SARS coronaviruses as human pathogens. bioRxiv. 2020 Jun 11. PMID: 32577639.
    Citations:    
  8. Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):723-733.e6. PMID: 31932164.
    Citations: 25     Fields:    Translation:Cells
  9. Zheng W, Zhao W, Wu M, Song X, Caro F, Sun X, Gazzaniga F, Stefanetti G, Oh S, Mekalanos JJ, Kasper DL. Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature. 2020 01; 577(7791):543-548. PMID: 31915378.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  10. Cartee RT, Thanawastien A, Griffin Iv TJ, Mekalanos JJ, Bart S, Killeen KP. A phase 1 randomized safety, reactogenicity, and immunogenicity study of Typhax: A novel protein capsular matrix vaccine candidate for the prevention of typhoid fever. PLoS Negl Trop Dis. 2020 01; 14(1):e0007912. PMID: 31905228.
    Citations:    Fields:    Translation:HumansCellsCTClinical Trials
  11. Liang X, Kamal F, Pei TT, Xu P, Mekalanos JJ, Dong TG. An onboard checking mechanism ensures effector delivery of the type VI secretion system in Vibrio cholerae. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):23292-23298. PMID: 31659021.
    Citations: 10     Fields:    Translation:Cells
  12. Caro F, Place NM, Mekalanos JJ. Analysis of lipoprotein transport depletion in Vibrio cholerae using CRISPRi. Proc Natl Acad Sci U S A. 2019 08 20; 116(34):17013-17022. PMID: 31371515.
    Citations: 5     Fields:    Translation:HumansCells
  13. Rivera-Chávez F, Mekalanos JJ. Cholera toxin promotes pathogen acquisition of host-derived nutrients. Nature. 2019 08; 572(7768):244-248. PMID: 31367037.
    Citations: 22     Fields:    Translation:AnimalsCells
  14. Bachta KER, Ozer EA, Pandit A, Marty FM, Mekalanos JJ, Hauser AR. Draft Genome Sequence of Pseudomonas aeruginosa Strain BWH047, a Sequence Type 235 Multidrug-Resistant Clinical Isolate Expressing High Levels of Colistin Resistance. Microbiol Resour Announc. 2019 Jul 18; 8(29). PMID: 31320415.
    Citations: 1     
  15. Griffin TJ, Thanawastien A, Cartee RT, Mekalanos JJ, Killeen KP. In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate. Hum Vaccin Immunother. 2019; 15(6):1310-1316. PMID: 31021700.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Ji X, Zou J, Peng H, Stolle AS, Xie R, Zhang H, Peng B, Mekalanos JJ, Zheng J. Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9578-9585. PMID: 31004054.
    Citations: 13     Fields:    Translation:Cells
  17. Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ. Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 2019 03; 567(7747):194-199. PMID: 30787435.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  18. Cabello FC, Cohen SN, Curtiss R, Dougan G, van Embden J, Finlay BB, Heffron F, Helinski D, Hull R, Hull S, Isberg R, Kopecko DJ, Levy S, Mekalanos J, Ortiz JM, Rappuoli R, Roberts MC, So M, Timmis KN. Farewell Stan Stanley Falkow: 1934-2018. Environ Microbiol. 2018 Jul; 20(7):2322-2333. PMID: 30146753.
    Citations:    Fields:    
  19. Toska J, Ho BT, Mekalanos JJ. Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):7997-8002. PMID: 30021850.
    Citations: 24     Fields:    Translation:Cells
  20. Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 07 12; 174(2):300-311.e11. PMID: 30007416.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  21. Kamareddine L, Robins WP, Berkey CD, Mekalanos JJ, Watnick PI. The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. Cell Metab. 2018 09 04; 28(3):449-462.e5. PMID: 29937377.
    Citations: 36     Fields:    Translation:AnimalsCells
  22. Hubbard TP, Billings G, Dörr T, Sit B, Warr AR, Kuehl CJ, Kim M, Delgado F, Mekalanos JJ, Lewnard JA, Waldor MK. A live vaccine rapidly protects against cholera in an infant rabbit model. Sci Transl Med. 2018 06 13; 10(445). PMID: 29899024.
    Citations: 17     Fields:    Translation:Animals
  23. Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC. Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6709-6714. PMID: 29891673.
    Citations: 18     Fields:    Translation:Cells
  24. LaPorte JP, Spinard EJ, Gomez-Chiarri M, Rowley DC, Mekalanos JJ, Nelson DR. Draft Genome Sequence of Bowmanella denitrificans JL63, a Bacterium Isolated from Whiteleg Shrimp (Litopenaeus vannamei) That Can Inhibit the Growth of Vibrio parahaemolyticus. Genome Announc. 2018 Apr 05; 6(14). PMID: 29622614.
    Citations:    
  25. Fu Y, Ho BT, Mekalanos JJ. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. . 2018 Feb 14; 23(2):274-281.e2. PMID: 29398650.
    Citations: 13     Translation:AnimalsCells
  26. Zhao W, Caro F, Robins W, Mekalanos JJ. Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence. Science. 2018 01 12; 359(6372):210-213. PMID: 29326272.
    Citations: 39     Fields:    Translation:AnimalsCells
  27. Ho BT, Fu Y, Dong TG, Mekalanos JJ. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci U S A. 2017 08 29; 114(35):9427-9432. PMID: 28808000.
    Citations: 15     Fields:    Translation:Cells
  28. Kongrueng J, Mitraparp-Arthorn P, Bangpanwimon K, Robins W, Vuddhakul V, Mekalanos J. Isolation of Bdellovibrio and like organisms and potential to reduce acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus. Dis Aquat Organ. 2017 05 11; 124(3):223-232. PMID: 28492178.
    Citations: 6     Fields:    Translation:AnimalsCells
  29. Hoque MM, Naser IB, Bari SM, Zhu J, Mekalanos JJ, Faruque SM. Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages. Sci Rep. 2016 11 28; 6:37956. PMID: 27892495.
    Citations: 20     Fields:    Translation:AnimalsCells
  30. Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ. SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. 2016 09 29; 537(7622):634-638. PMID: 27525505.
    Citations: 147     Fields:    Translation:Cells
  31. Del Tordello E, Danilchanka O, McCluskey AJ, Mekalanos JJ. Type VI secretion system sheaths as nanoparticles for antigen display. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3042-7. PMID: 26929342.
    Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
  32. Skurnik D, Clermont O, Guillard T, Launay A, Danilchanka O, Pons S, Diancourt L, Lebreton F, Kadlec K, Roux D, Jiang D, Dion S, Aschard H, Denamur M, Cywes-Bentley C, Schwarz S, Tenaillon O, Andremont A, Picard B, Mekalanos J, Brisse S, Denamur E. Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans. Mol Biol Evol. 2016 Apr; 33(4):898-914. PMID: 26613786.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  33. Roux D, Danilchanka O, Guillard T, Cattoir V, Aschard H, Fu Y, Angoulvant F, Messika J, Ricard JD, Mekalanos JJ, Lory S, Pier GB, Skurnik D. Fitness cost of antibiotic susceptibility during bacterial infection. Sci Transl Med. 2015 Jul 22; 7(297):297ra114. PMID: 26203082.
    Citations: 49     Fields:    Translation:AnimalsCells
  34. Altindis E, Dong T, Catalano C, Mekalanos J. Secretome analysis of Vibrio cholerae type VI secretion system reveals a new effector-immunity pair. mBio. 2015 Mar 10; 6(2):e00075. PMID: 25759499.
    Citations: 38     Fields:    Translation:Cells
  35. Thanawastien A, Cartee RT, Griffin TJ, Killeen KP, Mekalanos JJ. Conjugate-like immunogens produced as protein capsular matrix vaccines. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1143-51. PMID: 25699685.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  36. Dong TG, Dong S, Catalano C, Moore R, Liang X, Mekalanos JJ. Generation of reactive oxygen species by lethal attacks from competing microbes. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2181-6. PMID: 25646446.
    Citations: 45     Fields:    Translation:HumansCells
  37. Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. . 2014 Nov 12; 16(5):592-604. PMID: 25525791.
    Citations: 41     Translation:AnimalsCells
  38. Suzuki M, Danilchanka O, Mekalanos JJ. Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases. . 2014 Nov 12; 16(5):581-91. PMID: 25450857.
    Citations: 23     Translation:HumansAnimalsCells
  39. Kamruzzaman M, Robins WP, Bari SM, Nahar S, Mekalanos JJ, Faruque SM. RS1 satellite phage promotes diversity of toxigenic Vibrio cholerae by driving CTX prophage loss and elimination of lysogenic immunity. Infect Immun. 2014 Sep; 82(9):3636-43. PMID: 24935981.
    Citations: 7     Fields:    Translation:AnimalsCells
  40. Vercruysse M, Köhrer C, Davies BW, Arnold MF, Mekalanos JJ, RajBhandary UL, Walker GC. The highly conserved bacterial RNase YbeY is essential in Vibrio cholerae, playing a critical role in virulence, stress regulation, and RNA processing. PLoS Pathog. 2014 Jun; 10(6):e1004175. PMID: 24901994.
    Citations: 22     Fields:    Translation:AnimalsCells
  41. Fu Y, Mekalanos JJ. Infant Rabbit Colonization Competition Assays. Bio Protoc. 2014 Jun 05; 4(11). PMID: 29170743.
    Citations:    
  42. Altindis E, Fu Y, Mekalanos JJ. Proteomic analysis of Vibrio cholerae outer membrane vesicles. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):E1548-56. PMID: 24706774.
    Citations: 49     Fields:    Translation:Cells
  43. Yingkajorn M, Sermwitayawong N, Palittapongarnpimp P, Nishibuchi M, Robins WP, Mekalanos JJ, Vuddhakul V. Vibrio parahaemolyticus and its specific bacteriophages as an indicator in cockles (Anadara granosa) for the risk of V. parahaemolyticus infection in Southern Thailand. Microb Ecol. 2014 May; 67(4):849-56. PMID: 24682339.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  44. Robins WP, Mekalanos JJ. Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen. Curr Top Microbiol Immunol. 2014; 379:211-29. PMID: 24590676.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  45. Ho BT, Dong TG, Mekalanos JJ. A view to a kill: the bacterial type VI secretion system. . 2014 Jan 15; 15(1):9-21. PMID: 24332978.
    Citations: 218     Translation:HumansAnimalsCells
  46. Fu Y, Waldor MK, Mekalanos JJ. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. . 2013 Dec 11; 14(6):652-63. PMID: 24331463.
    Citations: 110     Translation:AnimalsCells
  47. Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB. Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20747-52. PMID: 24248354.
    Citations: 44     Fields:    Translation:HumansAnimalsCells