Harvard Catalyst Profiles

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John Joseph Mekalanos, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. U19AI109764 (KASPER, DENNIS L.) Mar 1, 2014 - Jun 30, 2019
    NIH
    Innovative Platforms for Antimicrobial Therapy and Vaccine Development
    Role: Co-Principal Investigator
  2. R01AI070963 (MEKALANOS, JOHN JOSEPH) Sep 15, 2007 - Aug 31, 2011
    NIH
    Genetic and Ecological Factors in Transmissibility and Epidemic Cycle of Cholera
    Role: Principal Investigator
  3. U54AI057159 (KASPER, DENNIS L.) Sep 4, 2003 - Aug 31, 2011
    NIH
    New England Regional Center of Excellence in Biodefense and Emerging Infectious D
    Role: Co-Principal Investigator
  4. R01GM068851 (MEKALANOS, JOHN JOSEPH) Sep 1, 2003 - Aug 31, 2007
    NIH
    Phages and Genomic Variation in Vibrio Cholerae Evolution
    Role: Principal Investigator
  5. T32AI007410 (MEKALANOS, JOHN J) Sep 30, 1992 - Aug 31, 2002
    NIH
    MECHANISMS IN MICROBIAL PATHOGENESIS
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Stolle AS, Meader BT, Toska J, Mekalanos JJ. Endogenous membrane stress induces T6SS activity in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2021 Jan 05; 118(1). PMID: 33443205.
    Citations:    Fields:    
  2. Caro F, Caro JA, Place NM, Mekalanos JJ. Transcriptional Silencing by TsrA in the Evolution of Pathogenic Vibrio cholerae Biotypes. mBio. 2020 11 24; 11(6). PMID: 33234688.
    Citations:    Fields:    
  3. Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR. Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27502-27508. PMID: 33087577.
    Citations:    Fields:    Translation:HumansCells
  4. Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ, Oliver A, Hauser AR. Long-term Persistence of an Extensively Drug-Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center. Clin Infect Dis. 2020 Sep 12; 71(6):1524-1531. PMID: 31583403.
    Citations: 1     Fields:    
  5. Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. 2020 07 09; 182(1):38-49.e17. PMID: 32544385.
    Citations: 5     Fields:    Translation:Cells
  6. Robins WP, Mekalanos JJ. Protein covariance networks reveal interactions important to the emergence of SARS coronaviruses as human pathogens. bioRxiv. 2020 Jun 11. PMID: 32577639.
    Citations:    
  7. Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):723-733.e6. PMID: 31932164.
    Citations: 14     Fields:    Translation:Cells
  8. Zheng W, Zhao W, Wu M, Song X, Caro F, Sun X, Gazzaniga F, Stefanetti G, Oh S, Mekalanos JJ, Kasper DL. Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature. 2020 01; 577(7791):543-548. PMID: 31915378.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  9. Cartee RT, Thanawastien A, Griffin Iv TJ, Mekalanos JJ, Bart S, Killeen KP. A phase 1 randomized safety, reactogenicity, and immunogenicity study of Typhax: A novel protein capsular matrix vaccine candidate for the prevention of typhoid fever. PLoS Negl Trop Dis. 2020 01; 14(1):e0007912. PMID: 31905228.
    Citations:    Fields:    Translation:HumansCellsCTClinical Trials
  10. Liang X, Kamal F, Pei TT, Xu P, Mekalanos JJ, Dong TG. An onboard checking mechanism ensures effector delivery of the type VI secretion system in Vibrio cholerae. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):23292-23298. PMID: 31659021.
    Citations: 7     Fields:    Translation:Cells
  11. Caro F, Place NM, Mekalanos JJ. Analysis of lipoprotein transport depletion in Vibrio cholerae using CRISPRi. Proc Natl Acad Sci U S A. 2019 08 20; 116(34):17013-17022. PMID: 31371515.
    Citations: 3     Fields:    Translation:HumansCells
  12. Rivera-Chávez F, Mekalanos JJ. Cholera toxin promotes pathogen acquisition of host-derived nutrients. Nature. 2019 08; 572(7768):244-248. PMID: 31367037.
    Citations: 15     Fields:    Translation:AnimalsCells
  13. Bachta KER, Ozer EA, Pandit A, Marty FM, Mekalanos JJ, Hauser AR. Draft Genome Sequence of Pseudomonas aeruginosa Strain BWH047, a Sequence Type 235 Multidrug-Resistant Clinical Isolate Expressing High Levels of Colistin Resistance. Microbiol Resour Announc. 2019 Jul 18; 8(29). PMID: 31320415.
    Citations: 1     
  14. Griffin TJ, Thanawastien A, Cartee RT, Mekalanos JJ, Killeen KP. In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate. Hum Vaccin Immunother. 2019; 15(6):1310-1316. PMID: 31021700.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Ji X, Zou J, Peng H, Stolle AS, Xie R, Zhang H, Peng B, Mekalanos JJ, Zheng J. Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9578-9585. PMID: 31004054.
    Citations: 9     Fields:    Translation:Cells
  16. Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ. Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 2019 03; 567(7747):194-199. PMID: 30787435.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  17. Cabello FC, Cohen SN, Curtiss R, Dougan G, van Embden J, Finlay BB, Heffron F, Helinski D, Hull R, Hull S, Isberg R, Kopecko DJ, Levy S, Mekalanos J, Ortiz JM, Rappuoli R, Roberts MC, So M, Timmis KN. Farewell Stan Stanley Falkow: 1934-2018. Environ Microbiol. 2018 Jul; 20(7):2322-2333. PMID: 30146753.
    Citations:    Fields:    
  18. Toska J, Ho BT, Mekalanos JJ. Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):7997-8002. PMID: 30021850.
    Citations: 17     Fields:    Translation:Cells
  19. Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 07 12; 174(2):300-311.e11. PMID: 30007416.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  20. Kamareddine L, Robins WP, Berkey CD, Mekalanos JJ, Watnick PI. The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. Cell Metab. 2018 09 04; 28(3):449-462.e5. PMID: 29937377.
    Citations: 27     Fields:    Translation:AnimalsCells
  21. Hubbard TP, Billings G, Dörr T, Sit B, Warr AR, Kuehl CJ, Kim M, Delgado F, Mekalanos JJ, Lewnard JA, Waldor MK. A live vaccine rapidly protects against cholera in an infant rabbit model. Sci Transl Med. 2018 06 13; 10(445). PMID: 29899024.
    Citations: 13     Fields:    Translation:Animals
  22. Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC. Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6709-6714. PMID: 29891673.
    Citations: 15     Fields:    Translation:Cells
  23. LaPorte JP, Spinard EJ, Gomez-Chiarri M, Rowley DC, Mekalanos JJ, Nelson DR. Draft Genome Sequence of Bowmanella denitrificans JL63, a Bacterium Isolated from Whiteleg Shrimp (Litopenaeus vannamei) That Can Inhibit the Growth of Vibrio parahaemolyticus. Genome Announc. 2018 Apr 05; 6(14). PMID: 29622614.
    Citations:    
  24. Fu Y, Ho BT, Mekalanos JJ. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. . 2018 Feb 14; 23(2):274-281.e2. PMID: 29398650.
    Citations: 11     Translation:AnimalsCells
  25. Zhao W, Caro F, Robins W, Mekalanos JJ. Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence. Science. 2018 01 12; 359(6372):210-213. PMID: 29326272.
    Citations: 32     Fields:    Translation:AnimalsCells
  26. Ho BT, Fu Y, Dong TG, Mekalanos JJ. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci U S A. 2017 08 29; 114(35):9427-9432. PMID: 28808000.
    Citations: 11     Fields:    Translation:Cells
  27. Kongrueng J, Mitraparp-Arthorn P, Bangpanwimon K, Robins W, Vuddhakul V, Mekalanos J. Isolation of Bdellovibrio and like organisms and potential to reduce acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus. Dis Aquat Organ. 2017 05 11; 124(3):223-232. PMID: 28492178.
    Citations: 5     Fields:    Translation:AnimalsCells
  28. Hoque MM, Naser IB, Bari SM, Zhu J, Mekalanos JJ, Faruque SM. Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages. Sci Rep. 2016 11 28; 6:37956. PMID: 27892495.
    Citations: 17     Fields:    Translation:AnimalsCells
  29. Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ. SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. 2016 09 29; 537(7622):634-638. PMID: 27525505.
    Citations: 126     Fields:    Translation:Cells
  30. Del Tordello E, Danilchanka O, McCluskey AJ, Mekalanos JJ. Type VI secretion system sheaths as nanoparticles for antigen display. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3042-7. PMID: 26929342.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
  31. Skurnik D, Clermont O, Guillard T, Launay A, Danilchanka O, Pons S, Diancourt L, Lebreton F, Kadlec K, Roux D, Jiang D, Dion S, Aschard H, Denamur M, Cywes-Bentley C, Schwarz S, Tenaillon O, Andremont A, Picard B, Mekalanos J, Brisse S, Denamur E. Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans. Mol Biol Evol. 2016 Apr; 33(4):898-914. PMID: 26613786.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  32. Roux D, Danilchanka O, Guillard T, Cattoir V, Aschard H, Fu Y, Angoulvant F, Messika J, Ricard JD, Mekalanos JJ, Lory S, Pier GB, Skurnik D. Fitness cost of antibiotic susceptibility during bacterial infection. Sci Transl Med. 2015 Jul 22; 7(297):297ra114. PMID: 26203082.
    Citations: 43     Fields:    Translation:AnimalsCells
  33. Altindis E, Dong T, Catalano C, Mekalanos J. Secretome analysis of Vibrio cholerae type VI secretion system reveals a new effector-immunity pair. mBio. 2015 Mar 10; 6(2):e00075. PMID: 25759499.
    Citations: 31     Fields:    Translation:Cells
  34. Thanawastien A, Cartee RT, Griffin TJ, Killeen KP, Mekalanos JJ. Conjugate-like immunogens produced as protein capsular matrix vaccines. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1143-51. PMID: 25699685.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  35. Dong TG, Dong S, Catalano C, Moore R, Liang X, Mekalanos JJ. Generation of reactive oxygen species by lethal attacks from competing microbes. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2181-6. PMID: 25646446.
    Citations: 38     Fields:    Translation:HumansCells
  36. Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. . 2014 Nov 12; 16(5):592-604. PMID: 25525791.
    Citations: 37     Translation:AnimalsCells
  37. Suzuki M, Danilchanka O, Mekalanos JJ. Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases. . 2014 Nov 12; 16(5):581-91. PMID: 25450857.
    Citations: 22     Translation:HumansAnimalsCells
  38. Kamruzzaman M, Robins WP, Bari SM, Nahar S, Mekalanos JJ, Faruque SM. RS1 satellite phage promotes diversity of toxigenic Vibrio cholerae by driving CTX prophage loss and elimination of lysogenic immunity. Infect Immun. 2014 Sep; 82(9):3636-43. PMID: 24935981.
    Citations: 7     Fields:    Translation:AnimalsCells
  39. Vercruysse M, Köhrer C, Davies BW, Arnold MF, Mekalanos JJ, RajBhandary UL, Walker GC. The highly conserved bacterial RNase YbeY is essential in Vibrio cholerae, playing a critical role in virulence, stress regulation, and RNA processing. PLoS Pathog. 2014 Jun; 10(6):e1004175. PMID: 24901994.
    Citations: 19     Fields:    Translation:AnimalsCells
  40. Fu Y, Mekalanos JJ. Infant Rabbit Colonization Competition Assays. Bio Protoc. 2014 Jun 05; 4(11). PMID: 29170743.
    Citations:    
  41. Altindis E, Fu Y, Mekalanos JJ. Proteomic analysis of Vibrio cholerae outer membrane vesicles. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):E1548-56. PMID: 24706774.
    Citations: 45     Fields:    Translation:Cells
  42. Yingkajorn M, Sermwitayawong N, Palittapongarnpimp P, Nishibuchi M, Robins WP, Mekalanos JJ, Vuddhakul V. Vibrio parahaemolyticus and its specific bacteriophages as an indicator in cockles (Anadara granosa) for the risk of V. parahaemolyticus infection in Southern Thailand. Microb Ecol. 2014 May; 67(4):849-56. PMID: 24682339.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  43. Robins WP, Mekalanos JJ. Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen. Curr Top Microbiol Immunol. 2014; 379:211-29. PMID: 24590676.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  44. Ho BT, Dong TG, Mekalanos JJ. A view to a kill: the bacterial type VI secretion system. . 2014 Jan 15; 15(1):9-21. PMID: 24332978.
    Citations: 193     Translation:HumansAnimalsCells
  45. Fu Y, Waldor MK, Mekalanos JJ. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. . 2013 Dec 11; 14(6):652-63. PMID: 24331463.
    Citations: 106     Translation:AnimalsCells
  46. Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB. Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20747-52. PMID: 24248354.
    Citations: 41     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  47. Ho BT, Basler M, Mekalanos JJ. Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer. Science. 2013 Oct 11; 342(6155):250-3. PMID: 24115441.
    Citations: 44     Fields:    Translation:Cells
  48. Mekalanos JJ. Vaccine economics: what price human life? Sci Transl Med. 2013 Sep 25; 5(204):204ed16. PMID: 24068732.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  49. Danilchanka O, Mekalanos JJ. Cyclic dinucleotides and the innate immune response. Cell. 2013 Aug 29; 154(5):962-970. PMID: 23993090.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  50. Shneider MM, Buth SA, Ho BT, Basler M, Mekalanos JJ, Leiman PG. PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature. 2013 Aug 15; 500(7462):350-353. PMID: 23925114.
    Citations: 164     Fields:    Translation:Cells
  51. Bari SM, Roky MK, Mohiuddin M, Kamruzzaman M, Mekalanos JJ, Faruque SM. Quorum-sensing autoinducers resuscitate dormant Vibrio cholerae in environmental water samples. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9926-31. PMID: 23716683.
    Citations: 18     Fields:    Translation:HumansCellsPHPublic Health
  52. Basler M, Ho BT, Mekalanos JJ. Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell. 2013 Feb 14; 152(4):884-94. PMID: 23415234.
    Citations: 165     Fields:    Translation:Cells
  53. Robins WP, Faruque SM, Mekalanos JJ. Coupling mutagenesis and parallel deep sequencing to probe essential residues in a genome or gene. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):E848-57. PMID: 23401533.
    Citations: 20     Fields:    Translation:Cells
  54. Dong TG, Ho BT, Yoder-Himes DR, Mekalanos JJ. Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae. Proc Natl Acad Sci U S A. 2013 Feb 12; 110(7):2623-8. PMID: 23362380.
    Citations: 117     Fields:    Translation:AnimalsCells
  55. Faruque SM, Mekalanos JJ. Phage-bacterial interactions in the evolution of toxigenic Vibrio cholerae. Virulence. 2012 Nov 15; 3(7):556-65. PMID: 23076327.
    Citations: 41     Fields:    Translation:HumansCells
  56. Mekalanos JJ, Robins W, Ussery DW, Davis BM, Schadt E, Waldor MK. Non-O1 Vibrio cholerae unlinked to cholera in Haiti. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):E3206; author reply E3207. PMID: 23035253.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  57. Bogard RW, Davies BW, Mekalanos JJ. MetR-regulated Vibrio cholerae metabolism is required for virulence. mBio. 2012; 3(5). PMID: 23015737.
    Citations: 14     Fields:    Translation:AnimalsCells
  58. Seed KD, Faruque SM, Mekalanos JJ, Calderwood SB, Qadri F, Camilli A. Phase variable O antigen biosynthetic genes control expression of the major protective antigen and bacteriophage receptor in Vibrio cholerae O1. PLoS Pathog. 2012 Sep; 8(9):e1002917. PMID: 23028317.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  59. Basler M, Mekalanos JJ. Type 6 secretion dynamics within and between bacterial cells. Science. 2012 Aug 17; 337(6096):815. PMID: 22767897.
    Citations: 103     Fields:    Translation:Cells
  60. Bashir A, Klammer A, Robins WP, Chin CS, Webster D, Paxinos E, Hsu D, Ashby M, Wang S, Peluso P, Sebra R, Sorenson J, Bullard J, Yen J, Valdovino M, Mollova E, Luong K, Lin S, LaMay B, Joshi A, Rowe L, Frace M, Tarr CL, Turnsek M, Davis BM, Kasarskis A, Mekalanos JJ, Waldor MK, Schadt EE. A hybrid approach for the automated finishing of bacterial genomes. Nat Biotechnol. 2012 Jul 01; 30(7):701-707. PMID: 22750883.
    Citations: 79     Fields:    Translation:Cells
  61. Dong TG, Mekalanos JJ. Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52. Nucleic Acids Res. 2012 Sep; 40(16):7766-75. PMID: 22723378.
    Citations: 47     Fields:    Translation:Cells
  62. Davies BW, Bogard RW, Young TS, Mekalanos JJ. Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence. Cell. 2012 Apr 13; 149(2):358-70. PMID: 22500802.
    Citations: 140     Fields:    Translation:HumansAnimalsCells