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Mekalanos, John
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John Joseph Mekalanos, Ph.D.
Title
Adele Lehman Professor of Microbiology and Molecular Genetics
Institution
Harvard Medical School
Department
Microbiology
Address
Harvard Medical School
MBIB, Room1035A
77 Avenue Louis Pasteur
Boston MA 02115
Phone
617/432-1935
Fax
617/738-7664
vCard
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research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
U19AI109764
(KASPER, DENNIS L.)
Mar 1, 2014 - Jun 30, 2019
NIH
Innovative Platforms for Antimicrobial Therapy and Vaccine Development
Role: Co-Principal Investigator
R01AI070963
(MEKALANOS, JOHN JOSEPH)
Sep 15, 2007 - Jul 31, 2012
NIH
Genetic and Ecological Factors in Transmissibility and Epidemic Cycle of Cholera
Role: Principal Investigator
U54AI057159
(KASPER, DENNIS L.)
Sep 4, 2003 - Feb 28, 2015
NIH
New England Regional Center of Excellence in Biodefense and Emerging Infectious D
Role: Co-Principal Investigator
R01GM068851
(MEKALANOS, JOHN JOSEPH)
Sep 1, 2003 - Jan 31, 2017
NIH
Phages and Genomic Variation in Vibrio Cholerae Evolution
Role: Principal Investigator
T32AI007410
(MEKALANOS, JOHN J)
Sep 30, 1992 - Aug 31, 2002
NIH
MECHANISMS IN MICROBIAL PATHOGENESIS
Role: Principal Investigator
R01AI026289
(MEKALANOS, JOHN JOSEPH)
May 1, 1988 - May 31, 2020
NIH
Coordinate Regulation of Bacterial Virulence Factors
Role: Principal Investigator
R37AI018045
(MEKALANOS, JOHN JOSEPH)
Jul 1, 1981 - Apr 30, 2024
NIH
Genetic analysis of toxinogenesis of Vibrio cholerae
Role: Principal Investigator
R01AI018045
(MEKALANOS, JOHN JOSEPH)
Jul 1, 1981 - Apr 30, 2019
NIH
Genetic Analysis of Toxinogenesis in Vibrio Cholerae
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Robins WP
,
Mekalanos JJ
. Covariance predicts conserved protein residue interactions important for the emergence and continued evolution of SARS-CoV-2 as a human pathogen. PLoS One. 2022; 17(7):e0270276.
PMID:
35895734
; PMCID:
PMC9328546
.
Citations:
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Ahmed SG
,
Oliva G
, Shao M, Wang X,
Mekalanos JJ
,
Brenner GJ
. Intratumoral injection of schwannoma with attenuated Salmonella typhimurium induces antitumor immunity and controls tumor growth. Proc Natl Acad Sci U S A. 2022 06 14; 119(24):e2202719119.
PMID:
35675425
; PMCID:
PMC9214496
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Rivera-Chávez F, Meader BT, Akosman S, Koprivica V,
Mekalanos JJ
. A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic Vibrio cholerae. Toxins (Basel). 2022 03 18; 14(3).
PMID:
35324722
; PMCID:
PMC8948642
.
Citations:
Fields:
Tox
Toxicology
Translation:
Animals
Cells
Robins WP
,
Mekalanos JJ
. Covariance predicts conserved protein residue interactions important to the emergence and continued evolution of SARS-CoV-2 as a human pathogen. bioRxiv. 2022 Feb 07.
PMID:
35169805
; PMCID:
PMC8845505
.
Citations:
Manera K, Caro F, Li H, Pei TT, Hersch SJ,
Mekalanos JJ
, Dong TG. Sensing of intracellular Hcp levels controls T6SS expression in Vibrio cholerae. Proc Natl Acad Sci U S A. 2021 06 22; 118(25).
PMID:
34161288
; PMCID:
PMC8237632
.
Citations:
3
Fields:
Sci
Science
Translation:
Cells
Stolle AS, Meader BT, Toska J,
Mekalanos JJ
. Endogenous membrane stress induces T6SS activity in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2021 01 05; 118(1).
PMID:
33443205
.
Citations:
9
Fields:
Sci
Science
Translation:
Cells
Caro F, Caro JA, Place NM,
Mekalanos JJ
. Transcriptional Silencing by TsrA in the Evolution of Pathogenic Vibrio cholerae Biotypes. mBio. 2020 11 24; 11(6).
PMID:
33234688
.
Citations:
Fields:
Mic
Microbiology
Translation:
Cells
Chang D
, Whiteley AT,
Bugda Gwilt K
,
Lencer WI
,
Mekalanos JJ
,
Thiagarajah JR
. Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27502-27508.
PMID:
33087577
.
Citations:
7
Fields:
Sci
Science
Translation:
Humans
Cells
Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A,
Mekalanos JJ
, Oliver A, Hauser AR. Long-term Persistence of an Extensively Drug-Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center. Clin Infect Dis. 2020 09 12; 71(6):1524-1531.
PMID:
31583403
; PMCID:
PMC7486844
.
Citations:
4
Fields:
Com
Communicable Diseases
Translation:
Humans
Cells
Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F,
Mekalanos JJ
,
Shao S
,
Lee ASY
,
Kranzusch PJ
. CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. 2020 07 09; 182(1):38-49.e17.
PMID:
32544385
.
Citations:
27
Fields:
Cel
Cell Biology
Translation:
Cells
Robins WP
,
Mekalanos JJ
. Protein covariance networks reveal interactions important to the emergence of SARS coronaviruses as human pathogens. bioRxiv. 2020 Jun 11.
PMID:
32577639
.
Citations:
Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B,
Mekalanos JJ
,
Kranzusch PJ
, Jain M, Pogliano J, Corbett KD. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):723-733.e6.
PMID:
31932164
.
Citations:
40
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Cells
Zheng W, Zhao W,
Wu M
, Song X, Caro F, Sun X,
Gazzaniga F
, Stefanetti G,
Oh S
,
Mekalanos JJ
,
Kasper DL
. Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature. 2020 01; 577(7791):543-548.
PMID:
31915378
; PMCID:
PMC7362890
.
Citations:
31
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Cartee RT, Thanawastien A, Griffin Iv TJ,
Mekalanos JJ
, Bart S, Killeen KP. A phase 1 randomized safety, reactogenicity, and immunogenicity study of Typhax: A novel protein capsular matrix vaccine candidate for the prevention of typhoid fever. PLoS Negl Trop Dis. 2020 01; 14(1):e0007912.
PMID:
31905228
; PMCID:
PMC6964911
.
Citations:
Fields:
Tro
Tropical Medicine
Translation:
Humans
Cells
CT
Clinical Trials
Liang X, Kamal F, Pei TT, Xu P,
Mekalanos JJ
, Dong TG. An onboard checking mechanism ensures effector delivery of the type VI secretion system in Vibrio cholerae. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):23292-23298.
PMID:
31659021
; PMCID:
PMC6859309
.
Citations:
17
Fields:
Sci
Science
Translation:
Cells
Caro F, Place NM,
Mekalanos JJ
. Analysis of lipoprotein transport depletion in Vibrio cholerae using CRISPRi. Proc Natl Acad Sci U S A. 2019 08 20; 116(34):17013-17022.
PMID:
31371515
; PMCID:
PMC6708369
.
Citations:
9
Fields:
Sci
Science
Translation:
Humans
Cells
Rivera-Chávez F,
Mekalanos JJ
. Cholera toxin promotes pathogen acquisition of host-derived nutrients. Nature. 2019 08; 572(7768):244-248.
PMID:
31367037
.
Citations:
35
Fields:
Sci
Science
Translation:
Animals
Cells
Bachta KER, Ozer EA, Pandit A, Marty FM,
Mekalanos JJ
, Hauser AR. Draft Genome Sequence of Pseudomonas aeruginosa Strain BWH047, a Sequence Type 235 Multidrug-Resistant Clinical Isolate Expressing High Levels of Colistin Resistance. Microbiol Resour Announc. 2019 Jul 18; 8(29).
PMID:
31320415
.
Citations:
1
Griffin TJ, Thanawastien A, Cartee RT,
Mekalanos JJ
, Killeen KP. In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate. Hum Vaccin Immunother. 2019; 15(6):1310-1316.
PMID:
31021700
.
Citations:
2
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Ji X, Zou J, Peng H, Stolle AS, Xie R, Zhang H, Peng B,
Mekalanos JJ
, Zheng J. Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9578-9585.
PMID:
31004054
; PMCID:
PMC6511005
.
Citations:
17
Fields:
Sci
Science
Translation:
Cells
Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS,
Lee ASY
,
Mekalanos JJ
,
Kranzusch PJ
. Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 2019 03; 567(7747):194-199.
PMID:
30787435
.
Citations:
78
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Cabello FC, Cohen SN, Curtiss R, Dougan G, van Embden J, Finlay BB, Heffron F, Helinski D, Hull R, Hull S, Isberg R, Kopecko DJ, Levy S,
Mekalanos J
, Ortiz JM, Rappuoli R, Roberts MC, So M, Timmis KN. Farewell Stan Stanley Falkow: 1934-2018. Environ Microbiol. 2018 Jul; 20(7):2322-2333.
PMID:
30146753
.
Citations:
Fields:
Env
Environmental Health
Mic
Microbiology
Toska J, Ho BT,
Mekalanos JJ
. Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):7997-8002.
PMID:
30021850
.
Citations:
36
Fields:
Sci
Science
Translation:
Cells
Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR,
Nowak RP
,
Fischer ES
, Gray NS,
Mekalanos JJ
,
Kranzusch PJ
. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 07 12; 174(2):300-311.e11.
PMID:
30007416
.
Citations:
81
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Kamareddine L,
Robins WP
, Berkey CD,
Mekalanos JJ
,
Watnick PI
. The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. Cell Metab. 2018 09 04; 28(3):449-462.e5.
PMID:
29937377
; PMCID:
PMC6125180
.
Citations:
49
Fields:
Cel
Cell Biology
Met
Metabolism
Translation:
Animals
Cells
Hubbard TP, Billings G, Dörr T, Sit B, Warr AR, Kuehl CJ, Kim M, Delgado F,
Mekalanos JJ
, Lewnard JA,
Waldor MK
. A live vaccine rapidly protects against cholera in an infant rabbit model. Sci Transl Med. 2018 06 13; 10(445).
PMID:
29899024
; PMCID:
PMC6500431
.
Citations:
24
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Zheng S, Sham LT, Rubino FA, Brock KP,
Robins WP
,
Mekalanos JJ
,
Marks DS
,
Bernhardt TG
,
Kruse AC
. Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6709-6714.
PMID:
29891673
; PMCID:
PMC6042122
.
Citations:
22
Fields:
Sci
Science
Translation:
Cells
LaPorte JP, Spinard EJ, Gomez-Chiarri M, Rowley DC,
Mekalanos JJ
, Nelson DR. Draft Genome Sequence of Bowmanella denitrificans JL63, a Bacterium Isolated from Whiteleg Shrimp (Litopenaeus vannamei) That Can Inhibit the Growth of Vibrio parahaemolyticus. Genome Announc. 2018 Apr 05; 6(14).
PMID:
29622614
; PMCID:
PMC5887035
.
Citations:
Fu Y, Ho BT,
Mekalanos JJ
. Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell Host Microbe. 2018 Feb 14; 23(2):274-281.e2.
PMID:
29398650
; PMCID:
PMC6031135
.
Citations:
18
Fields:
Mic
Microbiology
Translation:
Animals
Cells
Zhao W, Caro F,
Robins W
,
Mekalanos JJ
. Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence. Science. 2018 01 12; 359(6372):210-213.
PMID:
29326272
.
Citations:
64
Fields:
Sci
Science
Translation:
Animals
Cells
Ho BT, Fu Y, Dong TG,
Mekalanos JJ
. Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci U S A. 2017 08 29; 114(35):9427-9432.
PMID:
28808000
; PMCID:
PMC5584461
.
Citations:
25
Fields:
Sci
Science
Translation:
Cells
Kongrueng J, Mitraparp-Arthorn P, Bangpanwimon K,
Robins W
, Vuddhakul V,
Mekalanos J
. Isolation of Bdellovibrio and like organisms and potential to reduce acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus. Dis Aquat Organ. 2017 05 11; 124(3):223-232.
PMID:
28492178
.
Citations:
10
Fields:
Bio
Biology
Vet
Veterinary Medicine
Translation:
Animals
Cells
Hoque MM, Naser IB, Bari SM, Zhu J,
Mekalanos JJ
, Faruque SM. Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages. Sci Rep. 2016 11 28; 6:37956.
PMID:
27892495
.
Citations:
23
Fields:
Sci
Science
Translation:
Animals
Cells