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profilePer-Olof Hasselgren, PH.D., M.D.

TitleGeorge H. A. Clowes, Jr. Professor of Surgery
InstitutionBeth Israel Deaconess Medical Center
DepartmentSurgery
AddressBeth Israel Deaconess Med Ctr
Surgery, St 8m 11
330 Brookline Ave
Boston MA 02215
Phone617/667-1810
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01NR008545     (HASSELGREN, PER-OLOF J)Sep 30, 2004 - Aug 31, 2009
NIH/NINR
C/EBP, atrogin-1, and muscle wasting
Role: Principal Investigator

R56NR008545     (HASSELGREN, PER-OLOF J)Jul 1, 2003 - Aug 31, 2010
NIH/NINR
C/EBP, atrogin-1, and muscle wasting
Role: Principal Investigator

R01DK060546     (HASSELGREN, PER-OLOF J)May 1, 2003 - Feb 28, 2008
NIH/NIDDK
C/EBP and IL-6 Production in Mucosa and Enterocytes
Role: Principal Investigator

R01DK044201     (HASSELGREN, PER-OLOF J)Apr 1, 1992 - Mar 31, 1995
NIH/NIDDK
INTESTINAL PROTEIN METABOLISM IN SEPSIS
Role: Principal Investigator

R01DK040644     (HASSELGREN, PER-OLOF J)Sep 1, 1988 - Aug 31, 1991
NIH/NIDDK
PROTEIN SYNTHESIS IN LIVER DURING SEPSIS
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mehrzad R, Nishino M, Nucera C, Dias-Santagata D, Hennessey JV, Hasselgren PO. Invasive follicular variant of papillary thyroid cancer harboring the NRAS mutation Q61K and presenting with bone metastasis-A case report. Int J Surg Case Rep. 2017; 38:180-184. PMID: 28780248.
    View in: PubMed
  2. Gavrila A, Hasselgren PO, Glasgow A, Doyle AN, Lee AJ, Fox P, Gautam S, Hennessey JV, Kolodny GM, Cypess AM. Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status. Thyroid. 2017 Jan; 27(1):1-10. PMID: 27750020.
    View in: PubMed
  3. Mehrzad R, Nishino M, Connolly J, Wang H, Mowschenson P, Hasselgren PO. The relationship between the follicular variant of papillary thyroid cancer and follicular adenomas. Surgery. 2016 May; 159(5):1396-406. PMID: 26782349.
    View in: PubMed
  4. Moon HS, Huh JY, Dincer F, Schneider BE, Hasselgren PO, Mantzoros CS. Identification and saturable nature of signaling pathways induced by metreleptin in humans: comparative evaluation of in vivo, ex vivo, and in vitro administration. Diabetes. 2015 Mar; 64(3):828-39. PMID: 25249580; PMCID: PMC4338590.
  5. Hasselgren PO. ß-Hydroxy-ß-methylbutyrate (HMB) and prevention of muscle wasting. Metabolism. 2014 Jan; 63(1):5-8. PMID: 24140096.
    View in: PubMed
  6. Castillero E, Alamdari N, Lecker SH, Hasselgren PO. Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes. Metabolism. 2013 Oct; 62(10):1495-502. PMID: 23866982.
    View in: PubMed
  7. Aversa Z, Alamdari N, Castillero E, Muscaritoli M, Rossi Fanelli F, Hasselgren PO. CaMKII activity is reduced in skeletal muscle during sepsis. J Cell Biochem. 2013 Jun; 114(6):1294-305. PMID: 23238742.
    View in: PubMed
  8. Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med. 2013 May; 19(5):635-9. PMID: 23603815; PMCID: PMC3650129.
  9. Castillero E, Alamdari N, Aversa Z, Gurav A, Hasselgren PO. PPARß/d regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting. PLoS One. 2013; 8(3):e59726. PMID: 23555761; PMCID: PMC3605288.
  10. Alamdari N, Toraldo G, Aversa Z, Smith I, Castillero E, Renaud G, Qaisar R, Larsson L, Jasuja R, Hasselgren PO. Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness. Am J Physiol Regul Integr Comp Physiol. 2012 Nov 15; 303(10):R1090-9. PMID: 23019215; PMCID: PMC3517670.
  11. Aversa Z, Alamdari N, Castillero E, Muscaritoli M, Rossi Fanelli F, Hasselgren PO. ß-Hydroxy-ß-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy. Biochem Biophys Res Commun. 2012 Jul 13; 423(4):739-43. PMID: 22705301; PMCID: PMC3399026.
  12. Alamdari N, Aversa Z, Castillero E, Hasselgren PO. Acetylation and deacetylation--novel factors in muscle wasting. Metabolism. 2013 Jan; 62(1):1-11. PMID: 22626763; PMCID: PMC3430797.
  13. Alamdari N, Hasselgren PO. Comment on Sirtuin 1 in skeletal muscle of cachectic tumour-bearing rats. J Cachexia Sarcopenia Muscle. 2012 Mar; 3(1):71-2. PMID: 22450731; PMCID: PMC3302989.
  14. Chamberlain W, Gonnella P, Alamdari N, Aversa Z, Hasselgren PO. Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells. Biochem Cell Biol. 2012 Apr; 90(2):200-8. PMID: 22292478.
    View in: PubMed
  15. Alamdari N, Aversa Z, Castillero E, Gurav A, Petkova V, Tizio S, Hasselgren PO. Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism. Biochem Biophys Res Commun. 2012 Jan 06; 417(1):528-33. PMID: 22166204; PMCID: PMC3261799.
  16. Gonnella P, Alamdari N, Tizio S, Aversa Z, Petkova V, Hasselgren PO. C/EBPß regulates dexamethasone-induced muscle cell atrophy and expression of atrogin-1 and MuRF1. J Cell Biochem. 2011 Jul; 112(7):1737-48. PMID: 21381078; PMCID: PMC3111873.
  17. Aversa Z, Alamdari N, Hasselgren PO. Molecules modulating gene transcription during muscle wasting in cancer, sepsis, and other critical illness. Crit Rev Clin Lab Sci. 2011 Mar-Apr; 48(2):71-86. PMID: 21871000.
    View in: PubMed
  18. Smith IJ, Aversa Z, Hasselgren PO, Pacelli F, Rosa F, Doglietto GB, Bossola M. Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. Muscle Nerve. 2011 Mar; 43(3):410-4. PMID: 21305563.
    View in: PubMed
  19. O'Neal P, Mowschenson P, Connolly J, Hasselgren PO. Large parathyroid tumors have an increased risk of atypia and carcinoma. Am J Surg. 2011 Aug; 202(2):146-50. PMID: 21256474.
    View in: PubMed
  20. Smith IJ, Aversa Z, Alamdari N, Petkova V, Hasselgren PO. Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle. J Cell Biochem. 2010 Nov 01; 111(4):1059-73. PMID: 20677217.
    View in: PubMed
  21. Menconi MJ, Arany ZP, Alamdari N, Aversa Z, Gonnella P, O'Neal P, Smith IJ, Tizio S, Hasselgren PO. Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle. Am J Physiol Endocrinol Metab. 2010 Oct; 299(4):E533-43. PMID: 20647557; PMCID: PMC2957862.
  22. Hasselgren PO, Alamdari N, Aversa Z, Gonnella P, Smith IJ, Tizio S. Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation. Curr Opin Clin Nutr Metab Care. 2010 Jul; 13(4):423-8. PMID: 20473154; PMCID: PMC2911625.
  23. Alamdari N, Smith IJ, Aversa Z, Hasselgren PO. Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Aug; 299(2):R509-20. PMID: 20538901; PMCID: PMC2928620.
  24. Itagaki K, Menconi M, Antoniu B, Zhang Q, Gonnella P, Soybel D, Hauser C, Hasselgren PO. Dexamethasone stimulates store-operated calcium entry and protein degradation in cultured L6 myotubes through a phospholipase A(2)-dependent mechanism. Am J Physiol Cell Physiol. 2010 May; 298(5):C1127-39. PMID: 20107037; PMCID: PMC2867385.
  25. Smith IJ, Alamdari N, O'Neal P, Gonnella P, Aversa Z, Hasselgren PO. Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism. Int J Biochem Cell Biol. 2010 May; 42(5):701-11. PMID: 20079455; PMCID: PMC2907176.
  26. O'Neal P, Alamdari N, Smith I, Poylin V, Menconi M, Hasselgren PO. Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle. J Cell Biochem. 2009 Nov 01; 108(4):963-73. PMID: 19777444.
    View in: PubMed
  27. O'Neal PB, Poylin V, Mowschenson P, Parangi S, Horowitz G, Pant P, Hasselgren PO. When initial postexcision PTH level does not fall appropriately during parathyroidectomy: what to do next? World J Surg. 2009 Aug; 33(8):1665-73. PMID: 19495864.
    View in: PubMed
  28. Goldfarb M, O'Neal P, Shih JL, Hartzband P, Connolly J, Hasselgren PO. Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. Endocr Pract. 2009 Jul-Aug; 15(5):463-8. PMID: 19491068; PMCID: PMC2917245.
  29. Alamdari N, O'Neal P, Hasselgren PO. Curcumin and muscle wasting: a new role for an old drug? Nutrition. 2009 Feb; 25(2):125-9. PMID: 19028079; PMCID: PMC3258441.
  30. Menconi M, Gonnella P, Petkova V, Lecker S, Hasselgren PO. Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes. J Cell Biochem. 2008 Oct 01; 105(2):353-64. PMID: 18615595; PMCID: PMC2901105.
  31. Smith IJ, Lecker SH, Hasselgren PO. Calpain activity and muscle wasting in sepsis. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E762-71. PMID: 18492780; PMCID: PMC2575901.
  32. Poylin V, Fareed MU, O'Neal P, Alamdari N, Reilly N, Menconi M, Hasselgren PO. The NF-kappaB inhibitor curcumin blocks sepsis-induced muscle proteolysis. Mediators Inflamm. 2008; 2008:317851. PMID: 18389075; PMCID: PMC2279164.
  33. Hasselgren PO. Ubiquitination, phosphorylation, and acetylation--triple threat in muscle wasting. J Cell Physiol. 2007 Dec; 213(3):679-89. PMID: 17657723.
    View in: PubMed
  34. Menconi M, Fareed M, O'Neal P, Poylin V, Wei W, Hasselgren PO. Role of glucocorticoids in the molecular regulation of muscle wasting. Crit Care Med. 2007 Sep; 35(9 Suppl):S602-8. PMID: 17713416.
    View in: PubMed
  35. Fang CH, Li B, James JH, Yahya A, Kadeer N, Guo X, Xiao C, Supp DM, Kagan RJ, Hasselgren PO, Sheriff S. GSK-3beta activity is increased in skeletal muscle after burn injury in rats. Am J Physiol Regul Integr Comp Physiol. 2007 Oct; 293(4):R1545-51. PMID: 17686886.
    View in: PubMed
  36. Reilly N, Poylin V, Menconi M, Onderdonk A, Bengmark S, Hasselgren PO. Probiotics potentiate IL-6 production in IL-1beta-treated Caco-2 cells through a heat shock-dependent mechanism. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1169-79. PMID: 17634198.
    View in: PubMed
  37. Evenson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S, Hasselgren PO. Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg. 2007 Jun; 193(6):707-12. PMID: 17512281.
    View in: PubMed
  38. Wei W, Yang H, Menconi M, Cao P, Chamberlain CE, Hasselgren PO. Treatment of cultured myotubes with the proteasome inhibitor beta-lactone increases the expression of the transcription factor C/EBPbeta. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C216-26. PMID: 16987992.
    View in: PubMed
  39. Yang H, Wei W, Menconi M, Hasselgren PO. Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent. Am J Physiol Regul Integr Comp Physiol. 2007 Jan; 292(1):R337-4. PMID: 16973938.
    View in: PubMed
  40. Evenson A, Mitchell J, Wei W, Poylin V, Parangi S, Hasselgren PO. The gene expression and activity of calpains and the muscle wasting-associated ubiquitin ligases, atrogin-1 and MuRF1, are not altered in patients with primary hyperparathyroidism. Int J Mol Med. 2006 Sep; 18(3):471-5. PMID: 16865232.
    View in: PubMed
  41. Wei W, Yang H, Cao P, Menconi M, Chamberlain C, Petkova V, Hasselgren PO. Degradation of C/EBPbeta in cultured myotubes is calpain-dependent. J Cell Physiol. 2006 Aug; 208(2):386-98. PMID: 16646084.
    View in: PubMed
  42. Fareed MU, Evenson AR, Wei W, Menconi M, Poylin V, Petkova V, Pignol B, Hasselgren PO. Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. Am J Physiol Regul Integr Comp Physiol. 2006 Jun; 290(6):R1589-97. PMID: 16455766.
    View in: PubMed
  43. Mitchell JC, Grant F, Evenson AR, Parker JA, Hasselgren PO, Parangi S. Preoperative evaluation of thyroid nodules with 18FDG-PET/CT. Surgery. 2005 Dec; 138(6):1166-74; discussion 1174-5. PMID: 16360405.
    View in: PubMed
  44. Evenson AR, Fareed MU, Menconi MJ, Mitchell JC, Hasselgren PO. GSK-3beta inhibitors reduce protein degradation in muscles from septic rats and in dexamethasone-treated myotubes. Int J Biochem Cell Biol. 2005 Oct; 37(10):2226-38. PMID: 16051512.
    View in: PubMed
  45. Li BG, Hasselgren PO, Fang CH. Insulin-like growth factor-I inhibits dexamethasone-induced proteolysis in cultured L6 myotubes through PI3K/Akt/GSK-3beta and PI3K/Akt/mTOR-dependent mechanisms. Int J Biochem Cell Biol. 2005 Oct; 37(10):2207-16. PMID: 15927518.
    View in: PubMed
  46. Yang H, Mammen J, Wei W, Menconi M, Evenson A, Fareed M, Petkova V, Hasselgren PO. Expression and activity of C/EBPbeta and delta are upregulated by dexamethasone in skeletal muscle. J Cell Physiol. 2005 Jul; 204(1):219-26. PMID: 15669083.
    View in: PubMed
  47. Yang H, Menconi MJ, Wei W, Petkova V, Hasselgren PO. Dexamethasone upregulates the expression of the nuclear cofactor p300 and its interaction with C/EBPbeta in cultured myotubes. J Cell Biochem. 2005 Apr 01; 94(5):1058-67. PMID: 15669015.
    View in: PubMed
  48. Fang CH, Li BG, James JH, King JK, Evenson AR, Warden GD, Hasselgren PO. Protein breakdown in muscle from burned rats is blocked by insulin-like growth factor i and glycogen synthase kinase-3beta inhibitors. Endocrinology. 2005 Jul; 146(7):3141-9. PMID: 15802492.
    View in: PubMed
  49. Hasselgren PO, Menconi MJ, Fareed MU, Yang H, Wei W, Evenson A. Novel aspects on the regulation of muscle wasting in sepsis. Int J Biochem Cell Biol. 2005 Oct; 37(10):2156-68. PMID: 16125115.
    View in: PubMed
  50. Wei W, Fareed MU, Evenson A, Menconi MJ, Yang H, Petkova V, Hasselgren PO. Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3. Am J Physiol Regul Integr Comp Physiol. 2005 Mar; 288(3):R580-90. PMID: 15563579.
    View in: PubMed
  51. Cai D, Frantz JD, Tawa NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 2004 Oct 15; 119(2):285-98. PMID: 15479644.
    View in: PubMed
  52. Menconi MJ, Wei W, Yang H, Wray CJ, Hasselgren PO. Treatment of cultured myotubes with the calcium ionophore A23187 increases proteasome activity via a CaMK II-caspase-calpain-dependent mechanism. Surgery. 2004 Aug; 136(2):135-42. PMID: 15300172.
    View in: PubMed
  53. Hershko DD, Robb BW, Wray CJ, Luo GJ, Hasselgren PO. Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-kappaB in cultured caco-2 cells. J Cell Biochem. 2004 Apr 01; 91(5):951-61. PMID: 15034930.
    View in: PubMed
  54. Li BG, Hasselgren PO, Fang CH, Warden GD. Insulin-like growth factor-I blocks dexamethasone-induced protein degradation in cultured myotubes by inhibiting multiple proteolytic pathways: 2002 ABA paper. J Burn Care Rehabil. 2004 Jan-Feb; 25(1):112-8. PMID: 14726748.
    View in: PubMed
  55. Hasselgren PO. Surgery in Sweden at the time of Halsted. Arch Surg. 2004 Jan; 139(1):100-12. PMID: 14718285.
    View in: PubMed
  56. Hershko DD, Robb BW, Luo GJ, Hungness ES, Hasselgren PO. Sodium arsenite downregulates transcriptional activity of AP-1 and CRE binding proteins in IL-1beta-treated Caco-2 cells by increasing the expression of the transcriptional repressor CREMalpha. J Cell Biochem. 2003 Oct 15; 90(3):627-40. PMID: 14523996.
    View in: PubMed
  57. Wray CJ, Mammen JM, Hershko DD, Hasselgren PO. Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle. Int J Biochem Cell Biol. 2003 May; 35(5):698-705. PMID: 12672461.
    View in: PubMed
  58. Luo G, Hershko DD, Robb BW, Wray CJ, Hasselgren PO. IL-1beta stimulates IL-6 production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NF-kappa B. Am J Physiol Regul Integr Comp Physiol. 2003 May; 284(5):R1249-54. PMID: 12676746.
    View in: PubMed
  59. Sun X, Wray C, Tian X, Hasselgren PO, Lu J. Expression of uncoupling protein 3 is upregulated in skeletal muscle during sepsis. Am J Physiol Endocrinol Metab. 2003 Sep; 285(3):E512-20. PMID: 12721157.
    View in: PubMed
  60. Hershko DD, Robb BW, Luo GJ, Paxton JH, Hasselgren PO. Interleukin-6 induces thermotolerance in cultured Caco-2 cells independent of the heat shock response. Cytokine. 2003 Jan 07; 21(1):1-9. PMID: 12668153.
    View in: PubMed
  61. Wray CJ, Mammen JM, Hasselgren PO. Catabolic response to stress and potential benefits of nutrition support. Nutrition. 2002 Nov-Dec; 18(11-12):971-7. PMID: 12431720.
    View in: PubMed
  62. Hungness ES, Robb BW, Luo GJ, Hershko DD, Hasselgren PO. Hyperthermia-induced heat shock activates the transcription factor c/EBP-beta and augments IL-6 production in human intestinal epithelial cells. J Am Coll Surg. 2002 Nov; 195(5):619-26. PMID: 12437247.
    View in: PubMed
  63. Hershko DD, Robb BW, Luo G, Hasselgren PO. Multiple transcription factors regulating the IL-6 gene are activated by cAMP in cultured Caco-2 cells. Am J Physiol Regul Integr Comp Physiol. 2002 Nov; 283(5):R1140-8. PMID: 12376407.
    View in: PubMed
  64. Hershko DD, Robb BW, Hungness ES, Luo G, Guo X, Hasselgren PO. Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-kappaB activity. Clin Sci (Lond). 2002 Oct; 103(4):381-90. PMID: 12241537.
    View in: PubMed
  65. Fang CH, Li BG, Wray CJ, Hasselgren PO. Insulin-like growth factor-I inhibits lysosomal and proteasome-dependent proteolysis in skeletal muscle after burn injury. J Burn Care Rehabil. 2002 Sep-Oct; 23(5):318-25. PMID: 12352132.
    View in: PubMed
  66. Wray CJ, Tomkinson B, Robb BW, Hasselgren PO. Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis. Biochem Biophys Res Commun. 2002 Aug 09; 296(1):41-7. PMID: 12147224.
    View in: PubMed
  67. Robb BW, Hershko DD, Paxton JH, Luo GJ, Hasselgren PO. Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells. Surgery. 2002 Aug; 132(2):226-31. PMID: 12219016.
    View in: PubMed
  68. Pritts TA, Wang Q, Sun X, Fischer DR, Hungness ES, Fischer JE, Wong HR, Hasselgren PO. The stress response decreases NF-kappaB activation in liver of endotoxemic mice. Shock. 2002 Jul; 18(1):33-7. PMID: 12095131.
    View in: PubMed
  69. Hungness ES, Luo GJ, Pritts TA, Sun X, Robb BW, Hershko D, Hasselgren PO. Transcription factors C/EBP-beta and -delta regulate IL-6 production in IL-1beta-stimulated human enterocytes. J Cell Physiol. 2002 Jul; 192(1):64-70. PMID: 12115737.
    View in: PubMed
  70. Hungness ES, Robb BW, Seeskin C, Hasselgren PO, Luchette FA. Early debridement for necrotizing pancreatitis: is it worthwhile? J Am Coll Surg. 2002 Jun; 194(6):740-4; discussion 744-5. PMID: 12081064.
    View in: PubMed
  71. Al-Ahmadie H, Hasselgren PO, Yassin R, Mutema G. Colocalized granular cell tumor and infiltrating ductal carcinoma of the breast. Arch Pathol Lab Med. 2002 Jun; 126(6):731-3. PMID: 12033967.
    View in: PubMed
  72. Wray CJ, Sun X, Gang GI, Hasselgren PO. Dantrolene downregulates the gene expression and activity of the ubiquitin-proteasome proteolytic pathway in septic skeletal muscle. J Surg Res. 2002 May 15; 104(2):82-7. PMID: 12020124.
    View in: PubMed
  73. Safal M, Lower EE, Hasselgren PO, Hungness ES, Gazder P, Aron B, Shaughnessy EA, Yassin R. Bilateral synchronous breast cancer and HER-2/neu overexpression. Breast Cancer Res Treat. 2002 Apr; 72(3):195-201. PMID: 12058961.
    View in: PubMed
  74. Pritts TA, Hungness ES, Hershko DD, Robb BW, Sun X, Luo GJ, Fischer JE, Wong HR, Hasselgren PO. Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells. Am J Physiol Regul Integr Comp Physiol. 2002 Apr; 282(4):R1016-26. PMID: 11893605.
    View in: PubMed
  75. Hasselgren PO, Azizkhan RG, Bower RH, Hurst JM, McDonough JJ, Neale HW, Warden GD. Festschrift for Josef E. Fischer, MD. Am J Surg. 2002 Apr; 183(4):325-492. PMID: 11975917.
    View in: PubMed
  76. Hungness ES, Pritts TA, Luo GJ, Hershko DD, Robb BW, Hasselgren PO. IL-1beta activates C/EBP-beta and delta in human enterocytes through a mitogen-activated protein kinase signaling pathway. Int J Biochem Cell Biol. 2002 Apr; 34(4):382-95. PMID: 11854037.
    View in: PubMed
  77. Pritts T, Hungness E, Wang Q, Robb B, Hershko D, Hasselgren PO. Mucosal and enterocyte IL-6 production during sepsis and endotoxemia--role of transcription factors and regulation by the stress response. Am J Surg. 2002 Apr; 183(4):372-83. PMID: 11975924.
    View in: PubMed
  78. Wang Q, Hasselgren PO. Heat shock response reduces intestinal permeability in septic mice: potential role of interleukin-10. Am J Physiol Regul Integr Comp Physiol. 2002 Mar; 282(3):R669-76. PMID: 11832385.
    View in: PubMed
  79. O'Brien DP, Nelson LA, Kemp CJ, Williams JL, Wang Q, Erwin CR, Hasselgren PO, Warner BW. Intestinal permeability and bacterial translocation are uncoupled after small bowel resection. J Pediatr Surg. 2002 Mar; 37(3):390-4. PMID: 11877654.
    View in: PubMed
  80. Penner G, Gang G, Sun X, Wray C, Hasselgren PO. C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle. Am J Physiol Regul Integr Comp Physiol. 2002 Feb; 282(2):R439-44. PMID: 11792653.
    View in: PubMed
  81. Sun X, Fischer DR, Pritts TA, Wray CJ, Hasselgren PO. Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle. Am J Physiol Regul Integr Comp Physiol. 2002 Feb; 282(2):R509-18. PMID: 11792661.
    View in: PubMed
  82. Hasselgren PO, Wray C, Mammen J. Molecular regulation of muscle cachexia: it may be more than the proteasome. Biochem Biophys Res Commun. 2002 Jan 11; 290(1):1-10. PMID: 11779124.
    View in: PubMed
  83. Hungness ES, Robb BW, Luo GJ, Pritts TA, Hershko DD, Hasselgren PO. Proteasome inhibitors activate the transcription factors C/EBP-beta and delta in human intestinal epithelial cells. Biochem Biophys Res Commun. 2002 Jan 11; 290(1):469-74. PMID: 11779194.
    View in: PubMed
  84. Hershko DD, Robb BW, Hungness ES, Luo G, Hasselgren PO. Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response. J Cell Biochem. 2002; 84(4):687-98. PMID: 11835394.
    View in: PubMed
  85. Luo G, Sun X, Hungness E, Hasselgren PO. Heat shock protects L6 myotubes from catabolic effects of dexamethasone and prevents downregulation of NF-kappaB. Am J Physiol Regul Integr Comp Physiol. 2001 Oct; 281(4):R1193-200. PMID: 11557628.
    View in: PubMed
  86. Wang Q, Fang CH, Hasselgren PO. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am J Physiol Regul Integr Comp Physiol. 2001 Sep; 281(3):R1013-23. PMID: 11507020.
    View in: PubMed
  87. O'Brien DP, Nelson LA, Stern LE, Williams JL, Kemp CJ, Wang Q, Tso P, Erwin CR, Hasselgren PO, Warner BW. Epithelial permeability is not increased in rats following small bowel resection. J Surg Res. 2001 May 01; 97(1):65-70. PMID: 11319882.
    View in: PubMed
  88. Penner CG, Gang G, Wray C, Fischer JE, Hasselgren PO. The transcription factors NF-kappab and AP-1 are differentially regulated in skeletal muscle during sepsis. Biochem Biophys Res Commun. 2001 Mar; 281(5):1331-6. PMID: 11243882.
    View in: PubMed
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  92. Wang Q, Sun X, Pritts TA, Wong HR, Hasselgren PO. Induction of the stress response increases interleukin-6 production in the intestinal mucosa of endotoxaemic mice. Clin Sci (Lond). 2000 Dec; 99(6):489-96. PMID: 11099391.
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  93. Fang CH, Sun X, Li BG, Fischer DR, Pritts TA, Penner G, Hasselgren PO. Burn injuries in rats upregulate the gene expression of the ubiquitin-conjugating enzyme E2(14k) in skeletal muscle. J Burn Care Rehabil. 2000 Nov-Dec; 21(6):528-34. PMID: 11194807.
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  94. Hungness ES, Safa M, Shaughnessy EA, Aron BS, Gazder PA, Hawkins HH, Lower EE, Seeskin C, Yassin RS, Hasselgren PO. Bilateral synchronous breast cancer: mode of detection and comparison of histologic features between the 2 breasts. Surgery. 2000 Oct; 128(4):702-7. PMID: 11015105.
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  95. Fang CH, Li BG, Fischer DR, Wang JJ, Runnels HA, Monaco JJ, Hasselgren PO. Burn injury upregulates the activity and gene expression of the 20 S proteasome in rat skeletal muscle. Clin Sci (Lond). 2000 Sep; 99(3):181-7. PMID: 11787469.
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  96. Hungness ES, Pritts TA, Luo GJ, Sun X, Penner CG, Hasselgren PO. The transcription factor activator protein-1 is activated and interleukin-6 production is increased in interleukin-1beta-stimulated human enterocytes. Shock. 2000 Sep; 14(3):386-91. PMID: 11028561.
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  97. Pritts TA, Moon MR, Wang Q, Hungness ES, Salzman AL, Fischer JE, Hasselgren PO. Activation of NF-kappaB varies in different regions of the gastrointestinal tract during endotoxemia. Shock. 2000 Aug; 14(2):118-22. PMID: 10947153.
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  98. Fang CH, Li BG, Sun X, Hasselgren PO. Insulin-like growth factor I reduces ubiquitin and ubiquitin-conjugating enzyme gene expression but does not inhibit muscle proteolysis in septic rats. Endocrinology. 2000 Aug; 141(8):2743-51. PMID: 10919258.
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  99. Pritts TA, Wang Q, Sun X, Moon MR, Fischer DR, Fischer JE, Wong HR, Hasselgren PO. Induction of the stress response in vivo decreases nuclear factor-kappa B activity in jejunal mucosa of endotoxemic mice. Arch Surg. 2000 Jul; 135(7):860-6. PMID: 10896383.
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  100. Li BG, Fang CH, Hasselgren P. Degradation of methoxysuccinyl-phe-leu-phe-7-amido-4-trifluoromethyl coumarin (FLF) in cultured myotubes and HepG2 cells is proteasome- and calpain/calcium-dependent. Int J Biochem Cell Biol. 2000 Jun; 32(6):677-86. PMID: 10785364.
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  101. Moon MR, Parikh AA, Pritts TA, Kane C, Fischer JE, Salzman AL, Hasselgren PO. Interleukin-1beta induces complement component C3 and IL-6 production at the basolateral and apical membranes in a human intestinal epithelial cell line. Shock. 2000 May; 13(5):374-8. PMID: 10807012.
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  102. Fischer D, Gang G, Pritts T, Hasselgren PO. Sepsis-induced muscle proteolysis is prevented by a proteasome inhibitor in vivo. Biochem Biophys Res Commun. 2000 Apr 02; 270(1):215-21. PMID: 10733930.
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  103. Luo GJ, Sun X, Hasselgren PO. Hyperthermia stimulates energy-proteasome-dependent protein degradation in cultured myotubes. Am J Physiol Regul Integr Comp Physiol. 2000 Mar; 278(3):R749-56. PMID: 10712297.
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  104. Fischer D, Sun X, Gang G, Pritts T, Hasselgren PO. The gene expression of ubiquitin ligase E3alpha is upregulated in skeletal muscle during sepsis in rats-potential role of glucocorticoids. Biochem Biophys Res Commun. 2000 Jan 19; 267(2):504-8. PMID: 10631091.
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  105. Parikh AA, Moon MR, Pritts TA, Fischer JE, Szabó C, Hasselgren PO, Salzman AL. IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling. Shock. 2000 Jan; 13(1):8-13. PMID: 10638662.
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  106. Williams A, Sun X, Fischer JE, Hasselgren PO. The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer. Surgery. 1999 Oct; 126(4):744-9; discussion 749-50. PMID: 10520924.
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  107. Moon R, Pritts TA, Parikh AA, Fischer JE, Salzman AL, Ryan M, Wong HR, Hasselgren PO. Stress response decreases the interleukin-1beta-induced production of complement component C3 in human intestinal epithelial cells. Clin Sci (Lond). 1999 Sep; 97(3):331-7. PMID: 10464058.
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  108. Hobler SC, Williams A, Fischer D, Wang JJ, Sun X, Fischer JE, Monaco JJ, Hasselgren PO. Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis. Am J Physiol. 1999 Aug; 277(2 Pt 2):R434-40. PMID: 10444550.
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  109. Williams AB, Decourten-Myers GM, Fischer JE, Luo G, Sun X, Hasselgren PO. Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism. FASEB J. 1999 Aug; 13(11):1435-43. PMID: 10428767.
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  110. Hasselgren PO. Glucocorticoids and muscle catabolism. Curr Opin Clin Nutr Metab Care. 1999 May; 2(3):201-5. PMID: 10456248.
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  112. Molloy M, Bower RH, Hasselgren PO, Dalton BJ. Cholangiography during laparoscopic cholecystectomy--cumulative sum analysis of an institutional learning curve. J Gastrointest Surg. 1999 Mar-Apr; 3(2):185-8. PMID: 10457344.
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  113. Moon MR, Parikh AA, Pritts TA, Fischer JE, Cottongim S, Szabo C, Salzman AL, Hasselgren PO. Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha. J Surg Res. 1999 Mar; 82(1):48-55. PMID: 10068525.
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  114. Hasselgren PO. Pathways of muscle protein breakdown in injury and sepsis. Curr Opin Clin Nutr Metab Care. 1999 Mar; 2(2):155-60. PMID: 10453347.
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  115. Hobler SC, Wang JJ, Williams AB, Melandri F, Sun X, Fischer JE, Hasselgren PO. Sepsis is associated with increased ubiquitinconjugating enzyme E214k mRNA in skeletal muscle. Am J Physiol. 1999 Feb; 276(2 Pt 2):R468-73. PMID: 9950926.
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  116. Hasselgren PO. Burns and metabolism. J Am Coll Surg. 1999 Feb; 188(2):98-103. PMID: 10024150.
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  117. Hasselgren PO, Fischer JE. Counter-regulatory hormones and mechanisms in amino acid metabolism with special reference to the catabolic response in skeletal muscle. Curr Opin Clin Nutr Metab Care. 1999 Jan; 2(1):9-14. PMID: 10453324.
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  118. Molloy M, Sorrell MJ, Bower RH, Hasselgren PO, Dalton BJ. Patterns of morbidity and resource consumption associated with laparoscopic cholecystectomy in a VA medical center. J Surg Res. 1999 Jan; 81(1):15-20. PMID: 9889051.
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  119. Pritts TA, Moon R, Fischer JE, Salzman AL, Hasselgren PO. Nuclear factor-kappaB is activated in intestinal mucosa during endotoxemia. Arch Surg. 1998 Dec; 133(12):1311-5. PMID: 9865648.
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  120. Williams A, Wang JJ, Wang L, Sun X, Fischer JE, Hasselgren PO. Sepsis in mice stimulates muscle proteolysis in the absence of IL-6. Am J Physiol. 1998 Dec; 275(6 Pt 2):R1983-91. PMID: 9843888.
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  121. Wang Q, Wang JJ, Fischer JE, Hasselgren PO. Mucosal production of complement C3 and serum amyloid A is differentially regulated in different parts of the gastrointestinal tract during endotoxemia in mice. J Gastrointest Surg. 1998 Nov-Dec; 2(6):537-46. PMID: 10457312.
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  122. Wang Q, Meyer TA, Boyce ST, Wang JJ, Sun X, Tiao G, Fischer JE, Hasselgren PO. Endotoxemia in mice stimulates production of complement C3 and serum amyloid A in mucosa of small intestine. Am J Physiol. 1998 Nov; 275(5 Pt 2):R1584-92. PMID: 9791077.
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  123. Wang L, Luo GJ, Wang JJ, Hasselgren PO. Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes. Shock. 1998 Oct; 10(4):298-306. PMID: 9788663.
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  124. Fang CH, Li BG, Wang JJ, Fischer JE, Hasselgren PO. Treatment of burned rats with insulin-like growth factor I inhibits the catabolic response in skeletal muscle. Am J Physiol. 1998 Oct; 275(4 Pt 2):R1091-8. PMID: 9756538.
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  125. Fang CH, Wang JJ, Hobler S, Li BG, Fischer JE, Hasselgren PO. Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats. Clin Sci (Lond). 1998 Aug; 95(2):225-33. PMID: 9680506.
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  126. Parikh AA, Moon MR, Kane CD, Salzman AL, Fischer JE, Hasselgren PO. Interleukin-6 production in human intestinal epithelial cells increases in association with the heat shock response. J Surg Res. 1998 Jun; 77(1):40-4. PMID: 9698530.
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  127. Fang CH, Li BG, James JH, Fischer JE, Hasselgren PO. The anabolic effects of IGF-1 in skeletal muscle after burn injury are not caused by increased cell volume. JPEN J Parenter Enteral Nutr. 1998 May-Jun; 22(3):115-9. PMID: 9586787.
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  128. Wang Q, Wang JJ, Boyce S, Fischer JE, Hasselgren PO. Endotoxemia and IL-1 beta stimulate mucosal IL-6 production in different parts of the gastrointestinal tract. J Surg Res. 1998 Apr; 76(1):27-31. PMID: 9695734.
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  129. Hobler SC, Williams AB, Fischer JE, Hasselgren PO. IGF-I stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats. Am J Physiol. 1998 Feb; 274(2 Pt 2):R571-6. PMID: 9486320.
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  130. Hasselgren PO, Fischer JE. Sepsis: stimulation of energy-dependent protein breakdown resulting in protein loss in skeletal muscle. World J Surg. 1998 Feb; 22(2):203-8. PMID: 9451937.
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  131. Fang CH, Li BG, Tiao G, Wang JJ, Fischer JE, Hasselgren PO. The molecular regulation of protein breakdown following burn injury is different in fast- and slow-twitch skeletal muscle. Int J Mol Med. 1998 Jan; 1(1):163-9. PMID: 9852215.
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  132. Hobler SC, Tiao G, Fischer JE, Monaco J, Hasselgren PO. Sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors. Am J Physiol. 1998 Jan; 274(1 Pt 2):R30-7. PMID: 9458895.
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  133. Moon R, Parikh AA, Szabo C, Fischer JE, Salzman AL, Hasselgren PO. Complement C3 production in human intestinal epithelial cells is regulated by interleukin 1beta and tumor necrosis factor alpha. Arch Surg. 1997 Dec; 132(12):1289-93. PMID: 9403532.
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  134. Fang CH, Li BG, James JH, Fischer JE, Hasselgren PO. Cytokines block the effects of insulin-like growth factor-I (IGF-I) on glucose uptake and lactate production in skeletal muscle but do not influence IGF-I-induced changes in protein turnover. Shock. 1997 Nov; 8(5):362-7. PMID: 9361347.
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  135. Parikh AA, Salzman AL, Fischer JE, Szabó C, Hasselgren PO. Interleukin-1 beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells. Shock. 1997 Oct; 8(4):249-55. PMID: 9329125.
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  136. Fang CH, Li BG, Wang JJ, Fischer JE, Hasselgren PO. Insulin-like growth factor 1 stimulates protein synthesis and inhibits protein breakdown in muscle from burned rats. JPEN J Parenter Enteral Nutr. 1997 Sep-Oct; 21(5):245-51. PMID: 9323685.
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  137. Meyer TA, Wang JJ, Tiao GM, Ogle CK, Fischer JE, Hasselgren PO. Sepsis and endotoxaemia in mice stimulate the expression of interleukin-I and interleukin-6 in the central nervous system. Clin Sci (Lond). 1997 May; 92(5):519-25. PMID: 9176027.
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  138. Parikh AA, Salzman AL, Kane CD, Fischer JE, Hasselgren PO. IL-6 production in human intestinal epithelial cells following stimulation with IL-1 beta is associated with activation of the transcription factor NF-kappa B. J Surg Res. 1997 Apr; 69(1):139-44. PMID: 9202660.
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  139. Noguchi Y, James JH, Fischer JE, Hasselgren PO. Increased glutamine consumption in small intestine epithelial cells during sepsis in rats. Am J Surg. 1997 Mar; 173(3):199-205. PMID: 9124626.
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  140. Tiao G, Lieberman M, Fischer JE, Hasselgren PO. Intracellular regulation of protein degradation during sepsis is different in fast- and slow-twitch muscle. Am J Physiol. 1997 Mar; 272(3 Pt 2):R849-56. PMID: 9087646.
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  142. Tiao G, Hobler S, Wang JJ, Meyer TA, Luchette FA, Fischer JE, Hasselgren PO. Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle. J Clin Invest. 1997 Jan 15; 99(2):163-8. PMID: 9005983; PMCID: PMC507782.
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  144. Ogle CK, Guo X, Hasselgren PO, Ogle JD, Alexander JW. The gut as a source of inflammatory cytokines after stimulation with endotoxin. Eur J Surg. 1997 Jan; 163(1):45-51. PMID: 9116111.
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  145. Fagan JM, Ganguly M, Tiao G, Fischer JE, Hasselgren PO. Sepsis increases oxidatively damaged proteins in skeletal muscle. Arch Surg. 1996 Dec; 131(12):1326-31; discussion 1331-2. PMID: 8956775.
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  146. James JH, Fang CH, Schrantz SJ, Hasselgren PO, Paul RJ, Fischer JE. Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis. J Clin Invest. 1996 Nov 15; 98(10):2388-97. PMID: 8941658; PMCID: PMC507691.
  147. O'Brien WJ, Lingrel JB, Fischer JE, Hasselgren PO. Sepsis increases skeletal muscle sodium, potassium-adenosinetriphosphatase activity without affecting messenger RNA or protein levels. J Am Coll Surg. 1996 Nov; 183(5):471-9. PMID: 8912616.
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  148. Ogle CK, Mao JX, Hasselgren PO, Ogle JD, Alexander JW. Production of cytokines and prostaglandin E2 by subpopulations of guinea pig enterocytes: effect of endotoxin and thermal injury. J Trauma. 1996 Aug; 41(2):298-305. PMID: 8760540.
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  149. Tiao GM, Hudson K, Lieberman MA, Fischer JE, Hasselgren PO. Identification of altered gene expression in skeletal muscle during sepsis using differential display. J Surg Res. 1996 Jul 15; 64(1):63-7. PMID: 8806475.
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  150. Espat NJ, Auffenberg T, Rosenberg JJ, Rogy M, Martin D, Fang CH, Hasselgren PO, Copeland EM, Moldawer LL. Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response. Am J Physiol. 1996 Jul; 271(1 Pt 2):R185-90. PMID: 8760219.
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  151. Noguchi Y, Meyer T, Tiao G, Fischer JE, Hasselgren PO. Sepsis increases putrescine concentration and protein synthesis in mucosa of small intestine in rats. Shock. 1996 May; 5(5):333-40. PMID: 9156788.
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  152. Tiao G, Fagan J, Roegner V, Lieberman M, Wang JJ, Fischer JE, Hasselgren PO. Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids. J Clin Invest. 1996 Jan 15; 97(2):339-48. PMID: 8567953; PMCID: PMC507023.
  153. Noguchi Y, Meyer TA, Tiao G, Ogle CK, Fischer JE, Hasselgren PO. Influence of sepsis and endotoxemia on polyamine metabolism in mucosa of small intestine in rats. Metabolism. 1996 Jan; 45(1):28-33. PMID: 8544773.
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  154. Tiao G, Noguchi Y, Lieberman MA, Fischer JE, Hasselgren PO. Sepsis stimulates polyamine biosynthesis in the liver and increases tissue levels of ornithine decarboxylase mRNA. Shock. 1995 Dec; 4(6):403-10. PMID: 8608396.
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  155. Hasselgren PO. Muscle protein metabolism during sepsis. Biochem Soc Trans. 1995 Nov; 23(4):1019-25. PMID: 8654673.
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  156. Higashiguchi T, Noguchi Y, Meyer T, Fischer JE, Hasselgren PO. Protein synthesis in isolated enterocytes from septic or endotoxaemic rats: regulation by glutamine. Clin Sci (Lond). 1995 Sep; 89(3):311-9. PMID: 7493429.
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  157. Meyer TA, Wang J, Tiao GM, Ogle CK, Fischer JE, Hasselgren PO. Sepsis and endotoxemia stimulate intestinal interleukin-6 production. Surgery. 1995 Aug; 118(2):336-42. PMID: 7638750.
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  158. Hasselgren PO. On "down-regulation of albumin synthesis in the rat by human recombinant interleukin-1 beta or turpentine and the response to nutrients". JPEN J Parenter Enteral Nutr. 1995 Jul-Aug; 19(4):257. PMID: 8523622.
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  159. Fang CH, James JH, Fischer JE, Hasselgren PO. Is muscle protein turnover regulated by intracellular glutamine during sepsis? JPEN J Parenter Enteral Nutr. 1995 Jul-Aug; 19(4):279-85. PMID: 8523626.
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  160. Meyer TA, Tiao GM, James JH, Noguchi Y, Ogle CK, Fischer JE, Hasselgren PO. Nitric oxide inhibits LPS-induced IL-6 production in enterocytes. J Surg Res. 1995 Jun; 58(6):570-5. PMID: 7791330.
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  161. Fang CH, Tiao G, James H, Ogle C, Fischer JE, Hasselgren PO. Burn injury stimulates multiple proteolytic pathways in skeletal muscle, including the ubiquitin-energy-dependent pathway. J Am Coll Surg. 1995 Feb; 180(2):161-70. PMID: 7850049.
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  162. Higashiguchi T, Yokoi H, Noguchi T, Kawarada Y, Mizumoto R, Hasselgren PO. The preoperative nutritional assessment of surgical patients with hepatic dysfunction. Surg Today. 1995; 25(2):113-8. PMID: 7772912.
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  163. Fang CH, James HJ, Ogle C, Fischer JE, Hasselgren PO. Influence of burn injury on protein metabolism in different types of skeletal muscle and the role of glucocorticoids. J Am Coll Surg. 1995 Jan; 180(1):33-42. PMID: 8000653.
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  164. Chance WT, Noguchi Y, Zhang X, Hasselgren PO, Fischer JE. Differential effects of tumor and parenteral nutrition on jejunal mucosal polyamines. Nutr Cancer. 1995; 23(1):23-32. PMID: 7739912.
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  165. Meyer TA, Noguchi Y, Ogle CK, Tiao G, Wang JJ, Fischer JE, Hasselgren PO. Endotoxin stimulates interleukin-6 production in intestinal epithelial cells. A synergistic effect with prostaglandin E2. Arch Surg. 1994 Dec; 129(12):1290-4; discussion 1294-5. PMID: 7986158.
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  166. Tiao G, Fagan JM, Samuels N, James JH, Hudson K, Lieberman M, Fischer JE, Hasselgren PO. Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle. J Clin Invest. 1994 Dec; 94(6):2255-64. PMID: 7989581; PMCID: PMC330052.
  167. Higashiguchi T, Noguchi Y, Noffsinger A, Fischer JE, Hasselgren PO. Sepsis increases production of total secreted proteins, vasoactive intestinal peptide, and peptide YY in isolated rat enterocytes. Am J Surg. 1994 Sep; 168(3):251-6. PMID: 8080063.
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  168. Tiao G, Rafferty J, Ogle C, Fischer JE, Hasselgren PO. Detrimental effect of nitric oxide synthase inhibition during endotoxemia may be caused by high levels of tumor necrosis factor and interleukin-6. Surgery. 1994 Aug; 116(2):332-7; discussion 337-8. PMID: 7519365.
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  169. Higashiguchi T, Noguchi Y, O'Brien W, Wagner K, Fischer JE, Hasselgren PO. Effect of sepsis on mucosal protein synthesis in different parts of the gastrointestinal tract in rats. Clin Sci (Lond). 1994 Aug; 87(2):207-11. PMID: 7924166.
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  170. Rafferty JF, Noguchi Y, Fischer JE, Hasselgren PO. Sepsis in rats stimulates cellular proliferation in the mucosa of the small intestine. Gastroenterology. 1994 Jul; 107(1):121-7. PMID: 8020655.
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  171. Zamir O, O'Brien W, Thompson R, Bloedow DC, Fischer JE, Hasselgren PO. Reduced muscle protein breakdown in septic rats following treatment with interleukin-1 receptor antagonist. Int J Biochem. 1994 Jul; 26(7):943-50. PMID: 8063018.
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  172. Hasselgren PO, Hummel RP, Georgian-Smith D, Fieler M. Breast biopsy with needle localization: accuracy of specimen x-ray and management of missed lesions. Surgery. 1993 Oct; 114(4):836-40; discussion 840-2. PMID: 8211702.
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  173. Zamir O, James JH, Hasselgren PO, Fischer JE. Evidence that inhibition of muscle amino acid uptake during endotoxemia is not mediated by glucocorticoids. Metabolism. 1993 Sep; 42(9):1190-4. PMID: 8412774.
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  174. Higashiguchi T, Hasselgren PO, Wagner K, Fischer JE. Effect of glutamine on protein synthesis in isolated intestinal epithelial cells. JPEN J Parenter Enteral Nutr. 1993 Jul-Aug; 17(4):307-14. PMID: 8271353.
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  175. O'Brien W, Hasselgren PO, Hummel RP, Coith R, Hyams D, Kurtzman L, Neale HW. Comparison of postoperative wound complications and early cancer recurrence between patients undergoing mastectomy with or without immediate breast reconstruction. Am J Surg. 1993 Jul; 166(1):1-5. PMID: 8392300.
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  176. Zamir O, Hasselgren PO, James H, Higashiguchi T, Fischer JE. Effect of tumor necrosis factor or interleukin-1 on muscle amino acid uptake and the role of glucocorticoids. Surg Gynecol Obstet. 1993 Jul; 177(1):27-32. PMID: 8322145.
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  177. James JH, Hasselgren PO, King JK, James LE, Fischer JE. Intracellular glutamine concentration does not decrease in all muscles during sepsis. J Surg Res. 1993 Jun; 54(6):558-64. PMID: 8412065.
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  178. Frederick JA, Hasselgren PO, Davis S, Higashiguchi T, Jacob TD, Fischer JE. Nitric oxide may upregulate in vivo hepatic protein synthesis during endotoxemia. Arch Surg. 1993 Feb; 128(2):152-6; discussion 156-7. PMID: 7679268.
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  179. Zamir O, Hasselgren PO, von Allmen D, Fischer JE. In vivo administration of interleukin-1 alpha induces muscle proteolysis in normal and adrenalectomized rats. Metabolism. 1993 Feb; 42(2):204-8. PMID: 8474317.
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  180. Hasselgren PO, Fischer JE. Regulation by insulin of muscle protein metabolism during sepsis and other catabolic conditions. Nutrition. 1992 Nov-Dec; 8(6):434-9. PMID: 1486252.
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  181. Zamir O, Hasselgren PO, Frederick JA, Fischer JE. Is the metabolic response to sepsis in skeletal muscle different in infants and adults? An experimental study in rats. J Pediatr Surg. 1992 Nov; 27(11):1399-403. PMID: 1479497.
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  182. Hasselgren PO, Fidler JP. Further evidence against the routine use of parathyroid ultrasonography prior to initial neck exploration for hyperparathyroidism. Am J Surg. 1992 Oct; 164(4):337-40. PMID: 1415940.
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  183. Zamir O, Hasselgren PO, O'Brien W, Thompson RC, Fischer JE. Muscle protein breakdown during endotoxemia in rats and after treatment with interleukin-1 receptor antagonist (IL-1ra). Ann Surg. 1992 Sep; 216(3):381-5; discussion 386-7. PMID: 1417187; PMCID: PMC1242630.
  184. von Allmen D, Hasselgren PO, Higashiguchi T, Frederick J, Zamir O, Fischer JE. Increased intestinal protein synthesis during sepsis and following the administration of tumour necrosis factor alpha or interleukin-1 alpha. Biochem J. 1992 Sep 01; 286 ( Pt 2):585-9. PMID: 1530589; PMCID: PMC1132937.
  185. von Allmen D, Hasselgren PO, Higashiguchi T, Fischer JE. Individual regulation of different hepatocellular functions during sepsis. Metabolism. 1992 Sep; 41(9):961-9. PMID: 1518425.
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  186. Zamir O, Hasselgren PO, Kunkel SL, Frederick J, Higashiguchi T, Fischer JE. Evidence that tumor necrosis factor participates in the regulation of muscle proteolysis during sepsis. Arch Surg. 1992 Feb; 127(2):170-4. PMID: 1540094.
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  187. Zamir O, Hasselgren PO, Higashiguchi T, Frederick JA, Fischer JE. Effect of sepsis or cytokine administration on release of gut peptides. Am J Surg. 1992 Jan; 163(1):181-4; discussion 184-5. PMID: 1733367.
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  188. Zamir O, Hasselgren PO, Higashiguchi T, Frederick JA, Fischer JE. Tumour necrosis factor (TNF) and interleukin-1 (IL-1) induce muscle proteolysis through different mechanisms. Mediators Inflamm. 1992; 1(4):247-50. PMID: 18475468; PMCID: PMC2365344.
  189. Angerås U, Hall-Angerås M, Wagner KR, James H, Hasselgren PO, Fischer JE. Tissue metabolite levels in different types of skeletal muscle during sepsis. Metabolism. 1991 Nov; 40(11):1147-51. PMID: 1943743.
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  190. von Allmen D, Li SJ, Hasselgren PO, Fischer JE. Effect of ischemia on protein synthesis in the septic liver. Surg Gynecol Obstet. 1991 Jun; 172(6):441-8. PMID: 1709761.
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  191. Zamir O, Hasselgren PO, von Allmen D, Fischer JE. The effect of interleukin-1 alpha and the glucocorticoid receptor blocker RU 38486 on total and myofibrillar protein breakdown in skeletal muscle. J Surg Res. 1991 Jun; 50(6):579-83. PMID: 2051768.
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  192. Hall-Angerås M, Angerås U, Zamir O, Hasselgren PO, Fischer JE. Effect of the glucocorticoid receptor antagonist RU 38486 on muscle protein breakdown in sepsis. Surgery. 1991 Apr; 109(4):468-73. PMID: 2008652.
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  193. Hall-Angerås M, Hasselgren PO, Dimlich RV, Fischer JE. Myofibrillar proteinase, cathepsin B, and protein breakdown rates in skeletal muscle from septic rats. Metabolism. 1991 Mar; 40(3):302-6. PMID: 2000044.
    View in: PubMed
  194. Hall-Angerås M, Angerås U, von Allmen D, Higashiguchi T, Zamir O, Hasselgren PO, Fischer JE. Influence of sepsis in rats on muscle protein turnover in vivo and in tissue incubated under different in vitro conditions. Metabolism. 1991 Mar; 40(3):247-51. PMID: 2000037.
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  195. Fischer JE, Hasselgren PO. Cytokines and glucocorticoids in the regulation of the "hepato-skeletal muscle axis" in sepsis. Am J Surg. 1991 Feb; 161(2):266-71. PMID: 1990881.
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  196. Hasselgren PO, Tricoli JV, Wieczorek D, Steigerwald KA, Angerås U, Hall-Angerås M, Fischer JE. Reduced levels of mRNA for myofibrillar proteins in skeletal muscle from septic rats. Life Sci. 1991; 49(10):753-60. PMID: 1875785.
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  197. Hiyama DT, von Allmen D, Rosenblum L, Ogle CK, Hasselgren PO, Fischer JE. Synthesis of albumin and acute-phase proteins in perfused liver after burn injury in rats. J Burn Care Rehabil. 1991 Jan-Feb; 12(1):1-6. PMID: 1708776.
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  198. Hasselgren PO, Zamir O, James JH, Fischer JE. Prostaglandin E2 does not regulate total or myofibrillar protein breakdown in incubated skeletal muscle from normal or septic rats. Biochem J. 1990 Aug 15; 270(1):45-50. PMID: 2118760; PMCID: PMC1131675.
  199. Hall-Angerås M, Angerås U, Zamir O, Hasselgren PO, Fischer JE. Interaction between corticosterone and tumor necrosis factor stimulated protein breakdown in rat skeletal muscle, similar to sepsis. Surgery. 1990 Aug; 108(2):460-6. PMID: 2382237.
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  200. Nordström G, Winsö O, Biber B, Hasselgren PO. Influence of pentobarbital and chloralose on metabolic and hemodynamic changes in liver ischemia. Ann Surg. 1990 Jul; 212(1):23-9. PMID: 2363600; PMCID: PMC1358070.
  201. von Allmen D, Hasselgren PO, Fischer JE. Hepatic protein synthesis in a modified septic rat model. J Surg Res. 1990 May; 48(5):476-80. PMID: 2191170.
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  202. Hall-Angerås M, Angerås U, Hasselgren PO, Fischer JE. Corticosterone alone does not explain increased muscle proteolysis in septic rats. J Surg Res. 1990 Apr; 48(4):368-72. PMID: 2338824.
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  203. Hasselgren PO, Hall-Angerås M, Angerås U, Benson D, James JH, Fischer JE. Regulation of total and myofibrillar protein breakdown in rat extensor digitorum longus and soleus muscle incubated flaccid or at resting length. Biochem J. 1990 Apr 01; 267(1):37-44. PMID: 2183796; PMCID: PMC1131240.
  204. Hasselgren PO, James JH, Benson DW, Li S, Fischer JE. Is there a circulating proteolysis-inducing factor during sepsis? Arch Surg. 1990 Apr; 125(4):510-4. PMID: 2322118.
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  205. James JH, Hasselgren PO, Hummel RP, Warner BW, Fischer JE. Effect of sepsis on amino acid transport system A and its response to insulin in incubated rat skeletal muscle. Metabolism. 1990 Apr; 39(4):335-40. PMID: 2182970.
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  206. Hall-Angerås M, Angerås U, Hasselgren PO, Fischer JE. Effects of elevated temperature on protein breakdown in muscles from septic rats. Am J Physiol. 1990 Apr; 258(4 Pt 1):C589-92. PMID: 2185639.
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  207. Warner BW, Hasselgren PO, Hummel RP, James JH, Pedersen P, Fischer JE. Effect of catabolic hormone infusion on protein turnover and amino acid uptake in skeletal muscle. Am J Surg. 1990 Mar; 159(3):295-300. PMID: 2305936.
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  208. Warner BW, Hasselgren PO, James JH, Hummel RP, Rigel DF, Fischer JE. Reduced amino acid transport in skeletal muscle caused by a circulating factor during endotoxemia. Ann Surg. 1990 Mar; 211(3):323-8. PMID: 2178567; PMCID: PMC1358438.
  209. Nordström G, Säljö A, Li SJ, Hasselgren PO. Effects of ischemia and reperfusion on protein synthesis in livers with different glutathione levels. Ann Surg. 1990 Jan; 211(1):97-102. PMID: 2294851; PMCID: PMC1357901.
  210. Pedersen P, Hasselgren PO, Angerås U, Hall-Angerås M, Warner BW, LaFrance R, Li S, Fischer JE. Protein synthesis in liver following infusion of the catabolic hormones corticosterone, epinephrine, and glucagon in rats. Metabolism. 1989 Oct; 38(10):927-32. PMID: 2477664.
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  211. Warner BW, Hummel RP, Hasselgren PO, James JH, Fischer JE. Inhibited amino acid uptake in skeletal muscle during starvation. JPEN J Parenter Enteral Nutr. 1989 Jul-Aug; 13(4):344-8. PMID: 2778939.
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  212. Hasselgren PO, James JH, Benson DW, Hall-Angerås M, Angerås U, Hiyama DT, Li S, Fischer JE. Total and myofibrillar protein breakdown in different types of rat skeletal muscle: effects of sepsis and regulation by insulin. Metabolism. 1989 Jul; 38(7):634-40. PMID: 2661965.
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  213. Benson DW, Hasselgren PO, Hiyama DT, James JH, Li S, Rigel DF, Fischer JE. Effect of sepsis on calcium uptake and content in skeletal muscle and regulation in vitro by calcium of total and myofibrillar protein breakdown in control and septic muscle: results from a preliminary study. Surgery. 1989 Jul; 106(1):87-93. PMID: 2740990.
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  214. Pedersen PV, Warner BW, Bjornson HS, Hiyama DT, Li S, Rigel DF, Hasselgren PO, Fischer JE. Hemodynamic and metabolic alterations during experimental sepsis in young and adult rats. Surg Gynecol Obstet. 1989 Feb; 168(2):148-56. PMID: 2911792.
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  215. Pedersen P, Li SJ, Hasselgren PO, LaFrance R, Fischer JE. Administration of balanced or BCAA-enriched amino acid solution in septic rats. Effects on protein synthesis in the liver. Ann Surg. 1988 Dec; 208(6):714-20. PMID: 3143320; PMCID: PMC1493827.
  216. Hummel RP, Hasselgren PO, James JH, Warner BW, Fischer JE. The effect of sepsis in rats on skeletal muscle protein synthesis in vivo and in periphery and central core of incubated muscle preparations in vitro. Metabolism. 1988 Dec; 37(12):1120-7. PMID: 3193899.
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  217. Nordström G, Säljö A, Hasselgren PO. Studies on the possible role of oxygen-derived free radicals for impairment of protein and energy metabolism in liver ischemia. Circ Shock. 1988 Oct; 26(2):115-26. PMID: 3197260.
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  218. Adlerberth A, Persson S, Hansson G, Hasselgren PO. Protein synthesis and quantitative morphology in thyroid tissue from hyperthyroid patients after preoperative treatment with antithyroid or beta-adrenergic antagonist drugs. J Clin Endocrinol Metab. 1988 Oct; 67(4):663-8. PMID: 2458376.
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  219. Pedersen P, Hasselgren PO, Li SJ, Hiyama DT, Fischer JE. Synthesis of acute-phase proteins in perfused liver following administration of recombinant interleukin 1 alpha to normal or adrenalectomized rats. J Surg Res. 1988 Oct; 45(4):333-41. PMID: 2458506.
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  220. Hasselgren PO, Pedersen P, Sax HC, Warner BW, Fischer JE. Methods for studying protein synthesis and degradation in liver and skeletal muscle. J Surg Res. 1988 Oct; 45(4):389-415. PMID: 3047497.
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  221. Hasselgren PO, Pedersen P, Sax HC, Warner BW, Fischer JE. Current concepts of protein turnover and amino acid transport in liver and skeletal muscle during sepsis. Arch Surg. 1988 Aug; 123(8):992-9. PMID: 3293552.
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  222. Sax HC, Hasselgren PO, Talamini MA, Edwards LL, Fischer JE. Amino acid uptake in isolated, perfused liver: effect of trauma and sepsis. J Surg Res. 1988 Jul; 45(1):50-5. PMID: 3392992.
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  223. Hummel RP, Warner BW, James JH, Hasselgren PO, Fischer JE. Effects of indomethacin and leupeptin on muscle cathepsin B activity and protein degradation during sepsis. J Surg Res. 1988 Jul; 45(1):140-4. PMID: 3392987.
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  224. Hasselgren PO, LaFrance R, Pedersen P, James JH, Fischer JE. Infusion of a branched-chain amino acid-enriched solution and alpha-ketoisocaproic acid in septic rats: effects on nitrogen balance and skeletal muscle protein turnover. JPEN J Parenter Enteral Nutr. 1988 May-Jun; 12(3):244-9. PMID: 3392821.
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  225. Hasselgren PO, James JH, Warner BW, Hummel RP, Fischer JE. Protein synthesis and degradation in skeletal muscle from septic rats. Response to leucine and alpha-ketoisocaproic acid. Arch Surg. 1988 May; 123(5):640-4. PMID: 3358690.
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  226. Hasselgren PO, Warner BW, Hummel RP, James JH, Ogle CK, Fischer JE. Further evidence that accelerated muscle protein breakdown during sepsis is not mediated by prostaglandin E2. Ann Surg. 1988 Apr; 207(4):399-403. PMID: 3162671; PMCID: PMC1493441.
  227. Sax HC, Talamini MA, Hasselgren PO, Rosenblum L, Ogle CK, Fischer JE. Increased synthesis of secreted hepatic proteins during abdominal sepsis. J Surg Res. 1988 Feb; 44(2):109-16. PMID: 3339873.
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  228. Hummel RP, James JH, Warner BW, Hasselgren PO, Fischer JE. Evidence that cathepsin B contributes to skeletal muscle protein breakdown during sepsis. Arch Surg. 1988 Feb; 123(2):221-4. PMID: 3341905.
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  229. Warner BW, Hasselgren PO, James JH, Bialkowska H, Rigel DF, Ogle C, Fischer JE. Superoxide dismutase in rats with sepsis. Effect on survival rate and amino acid transport. Arch Surg. 1987 Oct; 122(10):1142-6. PMID: 3662793.
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  230. Schröder T, Hasselgren PO, Brackett K, Joffe SN. Techniques of liver resection. Comparison of suction knife, ultrasonic dissector, and contact neodymium-YAG laser. Arch Surg. 1987 Oct; 122(10):1166-71. PMID: 3662798.
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  231. Adlerberth A, Angerås U, Jagenburg R, Lindstedt G, Stenström G, Hasselgren PO. Urinary excretion of 3-methylhistidine and creatinine and plasma concentrations of amino acids in hyperthyroid patients following preoperative treatment with antithyroid drug or beta-blocking agent: results from a prospective, randomized study. Metabolism. 1987 Jul; 36(7):637-42. PMID: 3600277.
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  232. Hasselgren PO, Chen IW, James JH, Sperling M, Warner BW, Fischer JE. Studies on the possible role of thyroid hormone in altered muscle protein turnover during sepsis. Ann Surg. 1987 Jul; 206(1):18-24. PMID: 3606230; PMCID: PMC1492930.
  233. Warner BW, James JH, Hasselgren PO, Hummel RP, Fischer JE. Effect of sepsis and starvation on amino acid uptake in skeletal muscle. J Surg Res. 1987 Apr; 42(4):377-82. PMID: 3553742.
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  234. Angerås U, Hasselgren PO. Protein degradation in skeletal muscle during experimental hyperthyroidism in rats and the effect of beta-blocking agents. Endocrinology. 1987 Apr; 120(4):1417-21. PMID: 2881774.
    View in: PubMed
  235. Warner BW, James JH, Hasselgren PO, LaFrance R, Fischer JE. Effect of catabolic hormone infusion on organ amino acid uptake. J Surg Res. 1987 Apr; 42(4):418-24. PMID: 3573767.
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  236. Hasselgren PO, Warner BW, James JH, Takehara H, Fischer JE. Effect of insulin on amino acid uptake and protein turnover in skeletal muscle from septic rats. Evidence for insulin resistance of protein breakdown. Arch Surg. 1987 Feb; 122(2):228-33. PMID: 3545143.
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  237. Hasselgren PO. Prevention and treatment of ischemia of the liver. Surg Gynecol Obstet. 1987 Feb; 164(2):187-96. PMID: 3544277.
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  238. Adlerberth A, Stenström G, Hasselgren PO. The selective beta 1-blocking agent metoprolol compared with antithyroid drug and thyroxine as preoperative treatment of patients with hyperthyroidism. Results from a prospective, randomized study. Ann Surg. 1987 Feb; 205(2):182-8. PMID: 3545108; PMCID: PMC1492817.
  239. Pedersen P, Säljö A, Hasselgren PO. Protein and energy metabolism in liver tissue following intravenous infusion of live E. coli bacteria in rats. Circ Shock. 1987; 21(1):59-64. PMID: 3545530.
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  240. Angerås U, Jagenburg R, Lindstedt G, Hasselgren PO. Effects of beta-blocking agents on urinary excretion of 3-methylhistidine during experimental hyperthyroidism in rats. Eur Surg Res. 1987; 19(1):23-30. PMID: 2878810.
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  241. Hasselgren PO, Talamini M, James JH, Fischer JE. Protein metabolism in different types of skeletal muscle during early and late sepsis in rats. Arch Surg. 1986 Aug; 121(8):918-23. PMID: 3729710.
    View in: PubMed
  242. Adlerberth A, Jagenburg R, Lindstedt G, Stenström G, Hasselgren PO. Effects of thyroid hormone and beta-adrenoceptor blocking agents on urinary excretion of 3-methylhistidine and plasma amino acids in man. Eur J Clin Invest. 1986 Aug; 16(4):316-20. PMID: 3093243.
    View in: PubMed
  243. Hasselgren PO, James JH, Warner BW, Ogle C, Takehara H, Fischer JE. Reduced muscle amino acid uptake in sepsis and the effects in vitro of septic plasma and interleukin-1. Surgery. 1986 Aug; 100(2):222-8. PMID: 3488596.
    View in: PubMed
  244. Warner BW, Hasselgren PO, Fischer JE. Effect of allopurinol and superoxide dismutase on survival rate in rats with sepsis. Curr Surg. 1986 Jul-Aug; 43(4):292-3. PMID: 3743119.
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  245. Angerås U, Jagenburg R, Hasselgren PO. Effects of thyroid hormone and beta-blocking agents on plasma amino acids in rats. Acta Chir Scand. 1986 May; 152:339-45. PMID: 3739542.
    View in: PubMed
  246. Hasselgren PO, James JH, Fischer JE. Inhibited muscle amino acid uptake in sepsis. Ann Surg. 1986 Apr; 203(4):360-5. PMID: 3963895; PMCID: PMC1251118.
  247. Angerås U, Oldfors A, Hasselgren PO. The effect of beta-adrenergic blockade on the myopathic changes in experimental hyperthyroidism in rats. Acta Pathol Microbiol Immunol Scand A. 1986 Mar; 94(2):91-9. PMID: 2872765.
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  248. Hall-Angerås M, Säljö A, Hasselgren PO. Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats. Circ Shock. 1986; 20(3):231-8. PMID: 3542276.
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  249. Hasselgren PO, Fischer JE. Septic encephalopathy. Etiology and management. Intensive Care Med. 1986; 12(1):13-6. PMID: 2872241.
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  250. Hasselgren PO, Säljö A, Seeman T. Protein turnover in skeletal muscle tissue from patients with hyperparathyroidism and the effect of calcium in vitro. Eur Surg Res. 1986; 18(6):337-42. PMID: 3780785.
    View in: PubMed
  251. Pedersen P, Seeman T, Hasselgren PO. Protein synthesis and degradation in liver tissue following induction of septic peritonitis in rats. Acta Chir Scand. 1986 Jan; 152:29-34. PMID: 3953215.
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  252. Hasselgren PO, Talamini M, LaFrance R, James JH, Peters JC, Fischer JE. Effect of indomethacin on proteolysis in septic muscle. Ann Surg. 1985 Nov; 202(5):557-62. PMID: 3901942; PMCID: PMC1250967.
  253. Stokland E, Wihed A, Ceder S, Lukes P, Hasselgren PO, Seeman T. Ultrasonic diagnosis of an aneurysm of the common hepatic artery. J Clin Ultrasound. 1985 Jun; 13(5):369-70. PMID: 3924975.
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  254. Nordström G, Seeman T, Hasselgren PO. Beneficial effect of allopurinol in liver ischemia. Surgery. 1985 Jun; 97(6):679-84. PMID: 4002116.
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  255. Angerås U, Hasselgren PO. Protein turnover in different types of skeletal muscle during experimental hyperthyroidism in rats. Acta Endocrinol (Copenh). 1985 May; 109(1):90-5. PMID: 4003000.
    View in: PubMed
  256. Fornander J, Bergmark J, Jagenburg R, Hasselgren PO. Evaluation of an in vitro method for the study of hepatic protein synthesis in liver ischemia. Eur Surg Res. 1985; 17(2):91-100. PMID: 3979420.
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  257. Fornander J, Seeman T, Hasselgren PO. Changes of protein synthesis in liver tissue following ligation of hepatic artery or portal vein in rats. Eur Surg Res. 1985; 17(2):101-8. PMID: 3979419.
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  258. Hasselgren PO, Hellman A, Jennische E, Nordström G. Failure of an increased dose of ATP-MgCl2 to improve protein synthesis and transmembrane potential in the postischemic liver. J Surg Res. 1984 Nov; 37(5):409-14. PMID: 6333552.
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  259. Hasselgren PO, Adlerberth A, Angerås U, Stenström G. Protein metabolism in skeletal muscle tissue from hyperthyroid patients after preoperative treatment with antithyroid drug or selective beta-blocking agent. Results from a prospective, randomized study. J Clin Endocrinol Metab. 1984 Nov; 59(5):835-9. PMID: 6207197.
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  260. Ullman M, Hasselgren PO. [Unusual localization of torsion of the appendix epiploica]. Lakartidningen. 1984 Sep 12; 81(37):3240. PMID: 6482602.
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  261. Hasselgren PO, Hagberg E, Malmer H, Säljö A, Seeman T. One instead of two knives for surgical incision. Does it increase the risk of postoperative wound infection? Arch Surg. 1984 Aug; 119(8):917-20. PMID: 6378145.
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  262. Hasselgren PO, Ivarsson L, Risberg B, Seeman T. Effects of prophylactic antibiotics in vascular surgery. A prospective, randomized, double-blind study. Ann Surg. 1984 Jul; 200(1):86-92. PMID: 6375599; PMCID: PMC1250399.
  263. Hasselgren PO, Hultén L, Karlström L. ["Cancer family syndrome"--description of a family with a hereditary incidence of malignant tumors of the colon and other organs]. Lakartidningen. 1984 Jun 13; 81(24):2451-3. PMID: 6738248.
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  264. Hasselgren PO, Jagenburg R, Karlström L, Pedersen P, Seeman T. Changes of protein metabolism in liver and skeletal muscle following trauma complicated by sepsis. J Trauma. 1984 Mar; 24(3):224-8. PMID: 6708141.
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  265. Fornander J, Hellman A, Hasselgren PO. Effects of methylprednisolone on protein synthesis and blood flow in the postischemic liver. Circ Shock. 1984; 12(4):287-95. PMID: 6722996.
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  266. Melberg PE, Styf J, Biber B, Hasselgren PO, Körner L, Seeman T. Muscular compartment pressure following reconstructive arterial surgery of the lower limbs. Acta Chir Scand. 1984; 150(2):129-33. PMID: 6609512.
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  267. Pedersen P, Biber B, Martinell S, Seeman T, Hasselgren PO. Hemodynamic and hematologic changes in a standardized trauma-sepsis model in rats. Circ Shock. 1984; 14(1):13-23. PMID: 6386216.
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  268. Fornander J, Hasselgren PO, Jagenburg R. Effects of liver ischemia on degradation of different classes of hepatic proteins. Acta Physiol Scand. 1984 Jan; 120(1):61-6. PMID: 6720328.
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  269. Ullman M, Hasselgren PO, Tveit E. Posttraumatic and postoperative acute acalculous cholecystitis. Acta Chir Scand. 1984; 150(6):507-9. PMID: 6495985.
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  270. Almskog BA, Haljamäe H, Hasselgren PO, Lund B, von der Decken A, Seeman T. Effects of hypovolemia on local metabolic changes in skeletal muscle following high velocity missile injury. Circ Shock. 1984; 12(4):253-64. PMID: 6722993.
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  271. Saretok T, Almersjö O, Biber B, Gustavsson B, Hasselgren PO. Effects of hydralazine on liver blood flow in normovolemic dogs. Acta Chir Scand. 1984; 150(1):1-4. PMID: 6702386.
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  272. Hasselgren PO, Eriksson B, Lukes P, Seeman T. False popliteal aneurysm caused by exostosis of the femur. J Cardiovasc Surg (Torino). 1983 Sep-Oct; 24(5):540-2. PMID: 6606640.
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  273. Hasselgren PO, Biber B, Fornander J. Improved blood flow and protein synthesis in the postischemic liver following infusion of dopamine. J Surg Res. 1983 Jan; 34(1):44-52. PMID: 6823101.
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  274. Adlerberth A, Hasselgren PO, Lukes P, Stenström G. Surgical excision of an adrenal myelolipoma. Ann Chir Gynaecol. 1983; 72(2):76-9. PMID: 6870165.
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  275. Malmgren S, Hasselgren PO, Hellman A, Seeman T. Increasing incidence of stab wounds. Acta Chir Scand. 1983; 149(4):337-40. PMID: 6613473.
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  276. Almskog BA, Haljamäe H, Hasselgren PO, Nordström G, Seeman T. Local metabolic changes in skeletal muscle following high-energy missile injury. J Trauma. 1982 May; 22(5):382-7. PMID: 7077699.
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  277. Hasselgren PO, Fornander J, Jagenburg R, Sundström E. Effects of live ischemia on hepatic protein synthesis in vitro and in vivo. Acta Physiol Scand. 1982 Jan; 114(1):143-8. PMID: 7136742.
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  278. Hasselgren PO, Säljö A, Fornander J, Lundstam S, Seeman T. Postoperative wound infections in patients with long preoperative hospital stay. Acta Chir Scand. 1982; 148(6):473-7. PMID: 7158204.
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  279. Hasselgren PO, Almskog B, Lund B, von der Decken A, Nordström G, Seeman T. Leucine incorporation into skeletal muscle proteins in vitro and protein synthesis by isolated ribosomes from skeletal muscle around a high velocity missile injury. Acta Chir Scand Suppl. 1982; 508:337-44. PMID: 6952697.
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  280. Hasselgren PO, Jennische E, Fornander J, Hellman A. No beneficial effect of ATP-MgCl2 on impaired transmembrane potential and protein synthesis in liver ischemia. Acta Chir Scand. 1982; 148(7):601-7. PMID: 7168290.
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  281. Fornander J, Gustavsson B, Hasselgren PO. [Posttraumatic hemobilia and ligation of the hepatic artery]. Lakartidningen. 1981 Dec 09; 78(50):4566-7. PMID: 7329187.
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  282. Hasselgren PO, Almersjö O, Seeman T. [Traumatic liver rupture - current views on surgical treatment]. Lakartidningen. 1981 Nov 18; 78(47):4262-4. PMID: 7035773.
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  283. Hasselgren PO, Holm J. Sources and routes in postoperative wound infections. Acta Chir Scand. 1981; 147(2):99-103. PMID: 7324749.
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  284. Hasselgren PO, Almersjö O, Gustavsson B, Seeman T. Trauma to the liver during a ten-year period. With special reference to morbidity and mortality after blunt trauma and stab wounds. Acta Chir Scand. 1981; 147(6):387-93. PMID: 7324770.
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  285. Hasselgren PO, Almersjö O, Gustavsson B, Seeman T, von der Decken A. Structural and functional changes in ribosomes from ischemic liver in the dog: effects of short-term hepatic artery ligation and hemorrhagic shock. Eur Surg Res. 1980; 12(1):30-8. PMID: 7389769.
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  286. Hasselgren PO. Acute pancreatitis in pregnancy. Report of two cases. Acta Chir Scand. 1980; 146(4):297-9. PMID: 7193393.
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  287. Hasselgren PO, Säljö A, Fornander J, Lundstam S, Saretok T, Seeman T. Postoperative wound infections--a prospective study in a newly opened hospital. Ann Chir Gynaecol. 1980; 69(6):269-72. PMID: 7212602.
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  288. Hasselgren PO, Almersjö O, Gustavsson B, Rosengren K. Amino acid incorporation into liver and tumor proteins in patients with hepatic neoplasms-effects of liver dearterialization. Acta Chir Scand. 1980; 146(4):271-5. PMID: 7468053.
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  289. Gustavsson B, Baldesten A, Hasselgren PO, Almersjö O. New assay of 5-fluorouracil in serum by isotachophoresis. J Chromatogr. 1979 Nov 07; 179(1):151-9. PMID: 536452.
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  290. Hasselgren PO, Almersjö O, Gustavsson B, Seeman T. Liver circulation and oxygen metabolism during short time ligation and the hepatic artery in the dog. Acta Chir Scand. 1979; 145(7):471-7. PMID: 539330.
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  291. Almskog BA, Hasselgren PO, Nordström G, Nylöf U, Seeman TA. Circulatory changes following multiple wounds to soft tissue. Acta Chir Scand Suppl. 1979; 489:261-70. PMID: 291261.
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  292. Hasselgren PO, Almersjö O, Gustavsson B, Seeman T. Amino acid incorporation into liver proteins during hemorrhagic shock in the dog. Eur Surg Res. 1979; 11(4):267-76. PMID: 527613.
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  293. Hasselgren PO, Bolin T. Postmenopausal tuberculous pyometra. Acta Obstet Gynecol Scand. 1977; 56(1):23-5. PMID: 842299.
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  294. Hasselgren PO, Engquist S, Sundström C. Pneumatosis cystoides intestinalis. Report of two cases. Ann Chir Gynaecol. 1977; 66(2):98-101. PMID: 869486.
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  295. Hasselgren PO, Rottier A. Aneurysm of the pancreaticoduodenal artery. A case report. Acta Chir Scand. 1976; 142(7):543-4. PMID: 1020595.
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  296. Sjöstrand J, Frizell M, Hasselgren PO. Effects of colchicine on axonal transport in peripheral nerves. J Neurochem. 1970 Nov; 17(11):1563-70. PMID: 4097508.
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  297. Frizell M, Hasselgren PO, Sjöstrand J. Axoplasmic transport of acetylcholinesterase and choline acetyltransferase in the vagus and hypoglossal nerve of the rabbit. Exp Brain Res. 1970 Jun 25; 10(5):526-31. PMID: 4194264.
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