Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Per-Olof Hasselgren, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NR008545 (HASSELGREN, PER-OLOF J) Sep 30, 2004 - Aug 31, 2009
    C/EBP, atrogin-1, and muscle wasting
    Role: Principal Investigator
  2. R56NR008545 (HASSELGREN, PER-OLOF J) Jul 1, 2003 - Aug 31, 2010
    C/EBP, atrogin-1, and muscle wasting
    Role: Principal Investigator
  3. R01DK060546 (HASSELGREN, PER-OLOF J) May 1, 2003 - Feb 28, 2008
    C/EBP and IL-6 Production in Mucosa and Enterocytes
    Role: Principal Investigator
  4. R01DK044201 (HASSELGREN, PER-OLOF J) Apr 1, 1992 - Mar 31, 1995
    Role: Principal Investigator
  5. R01DK040644 (HASSELGREN, PER-OLOF J) Sep 1, 1988 - Aug 31, 1991
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Broekhuis JM, James BC, Cummings RD, Hasselgren PO. Posttranslational Modifications in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, Classification, and Treatment. Cancers (Basel). 2022 Mar 22; 14(7). PMID: 35406382; PMCID: PMC8996999.
  2. Li C, Lopez B, Fligor S, Broekhuis JM, Maeda A, Duncan S, Chen HW, Choudhary A, Budwani S, Hasselgren PO, Mowschenson P, Mallur PS, James BC. Long-term voice changes after thyroidectomy: Results from a validated survey. Surgery. 2021 12; 170(6):1687-1691. PMID: 34344524.
    Citations:    Fields:    Translation:Humans
  3. Higgins S, James BC, Sacks B, Mowschenson P, Nishino M, Hasselgren PO. Can Cytologic and Sonographic Features Help Prevent Overtreatment of Bethesda V Thyroid Nodules? J Surg Res. 2021 12; 268:112-118. PMID: 34298210.
    Citations: 1     Fields:    Translation:Humans
  4. Nishino M, Mateo R, Kilim H, Feldman A, Elliott A, Shen C, Hasselgren PO, Wang H, Hartzband P, Hennessey JV. Repeat Fine Needle Aspiration Cytology Refines the Selection of Thyroid Nodules for Afirma Gene Expression Classifier Testing. Thyroid. 2021 08; 31(8):1253-1263. PMID: 33813868; PMCID: PMC8377518.
    Citations:    Fields:    Translation:Humans
  5. Hasselgren PO. The Smallpox Epidemics in America in the 1700s and the Role of the Surgeons: Lessons to be Learned During the Global Outbreak of COVID-19. World J Surg. 2020 09; 44(9):2837-2841. PMID: 32623571; PMCID: PMC7335227.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  6. Roth EM, Barrows CE, Nishino M, Sacks B, Hasselgren PO, James BC. Papillary thyroid cancer with extrathyroidal extension of desmoid-type fibromatosis. A case report of an aggressive presentation of an uncommon pathologic entity. Int J Surg Case Rep. 2019; 63:5-9. PMID: 31499326; PMCID: PMC6734537.
    Citations: 3     
  7. Mehrzad R, Nishino M, Nucera C, Dias-Santagata D, Hennessey JV, Hasselgren PO. Invasive follicular variant of papillary thyroid cancer harboring the NRAS mutation Q61K and presenting with bone metastasis-A case report. Int J Surg Case Rep. 2017; 38:180-184. PMID: 28780248; PMCID: PMC5547242.
    Citations: 1     
  8. Gavrila A, Hasselgren PO, Glasgow A, Doyle AN, Lee AJ, Fox P, Gautam S, Hennessey JV, Kolodny GM, Cypess AM. Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status. Thyroid. 2017 01; 27(1):1-10. PMID: 27750020.
    Citations: 13     Fields:    Translation:Humans
  9. Mehrzad R, Nishino M, Connolly J, Wang H, Mowschenson P, Hasselgren PO. The relationship between the follicular variant of papillary thyroid cancer and follicular adenomas. Surgery. 2016 May; 159(5):1396-406. PMID: 26782349.
    Citations: 9     Fields:    Translation:Humans
  10. Moon HS, Huh JY, Dincer F, Schneider BE, Hasselgren PO, Mantzoros CS. Identification and saturable nature of signaling pathways induced by metreleptin in humans: comparative evaluation of in vivo, ex vivo, and in vitro administration. Diabetes. 2015 Mar; 64(3):828-39. PMID: 25249580; PMCID: PMC4338590.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  11. Hasselgren PO. ß-Hydroxy-ß-methylbutyrate (HMB) and prevention of muscle wasting. Metabolism. 2014 Jan; 63(1):5-8. PMID: 24140096.
    Citations: 5     Fields:    Translation:Animals
  12. Castillero E, Alamdari N, Lecker SH, Hasselgren PO. Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes. Metabolism. 2013 Oct; 62(10):1495-502. PMID: 23866982.
    Citations: 21     Fields:    Translation:AnimalsCells
  13. Aversa Z, Alamdari N, Castillero E, Muscaritoli M, Rossi Fanelli F, Hasselgren PO. CaMKII activity is reduced in skeletal muscle during sepsis. J Cell Biochem. 2013 Jun; 114(6):1294-305. PMID: 23238742.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med. 2013 May; 19(5):635-9. PMID: 23603815.
    Citations: 317     Fields:    Translation:HumansAnimalsCells
  15. Castillero E, Alamdari N, Aversa Z, Gurav A, Hasselgren PO. PPARß/d regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting. PLoS One. 2013; 8(3):e59726. PMID: 23555761; PMCID: PMC3605288.
    Citations: 18     Fields:    Translation:AnimalsCells
  16. Alamdari N, Toraldo G, Aversa Z, Smith I, Castillero E, Renaud G, Qaisar R, Larsson L, Jasuja R, Hasselgren PO. Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness. Am J Physiol Regul Integr Comp Physiol. 2012 Nov 15; 303(10):R1090-9. PMID: 23019215.
    Citations: 10     Fields:    Translation:AnimalsCells
  17. Aversa Z, Alamdari N, Castillero E, Muscaritoli M, Rossi Fanelli F, Hasselgren PO. ß-Hydroxy-ß-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy. Biochem Biophys Res Commun. 2012 Jul 13; 423(4):739-43. PMID: 22705301.
    Citations: 20     Fields:    Translation:AnimalsCells
  18. Alamdari N, Aversa Z, Castillero E, Hasselgren PO. Acetylation and deacetylation--novel factors in muscle wasting. Metabolism. 2013 Jan; 62(1):1-11. PMID: 22626763.
    Citations: 21     Fields:    Translation:HumansCells
  19. Alamdari N, Hasselgren PO. Comment on Sirtuin 1 in skeletal muscle of cachectic tumour-bearing rats. J Cachexia Sarcopenia Muscle. 2012 Mar; 3(1):71-2. PMID: 22450731.
    Citations:    Fields:    
  20. Chamberlain W, Gonnella P, Alamdari N, Aversa Z, Hasselgren PO. Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells. Biochem Cell Biol. 2012 Apr; 90(2):200-8. PMID: 22292478.
    Citations: 7     Fields:    Translation:AnimalsCells
  21. Alamdari N, Aversa Z, Castillero E, Gurav A, Petkova V, Tizio S, Hasselgren PO. Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism. Biochem Biophys Res Commun. 2012 Jan 06; 417(1):528-33. PMID: 22166204.
    Citations: 35     Fields:    Translation:AnimalsCells
  22. Gonnella P, Alamdari N, Tizio S, Aversa Z, Petkova V, Hasselgren PO. C/EBPß regulates dexamethasone-induced muscle cell atrophy and expression of atrogin-1 and MuRF1. J Cell Biochem. 2011 Jul; 112(7):1737-48. PMID: 21381078.
    Citations: 13     Fields:    Translation:AnimalsCells
  23. Aversa Z, Alamdari N, Hasselgren PO. Molecules modulating gene transcription during muscle wasting in cancer, sepsis, and other critical illness. Crit Rev Clin Lab Sci. 2011 Mar-Apr; 48(2):71-86. PMID: 21871000.
    Citations: 4     Fields:    Translation:HumansCells
  24. Smith IJ, Aversa Z, Hasselgren PO, Pacelli F, Rosa F, Doglietto GB, Bossola M. Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. Muscle Nerve. 2011 Mar; 43(3):410-4. PMID: 21305563.
    Citations: 13     Fields:    Translation:HumansCells
  25. O'Neal P, Mowschenson P, Connolly J, Hasselgren PO. Large parathyroid tumors have an increased risk of atypia and carcinoma. Am J Surg. 2011 Aug; 202(2):146-50. PMID: 21256474.
    Citations: 7     Fields:    Translation:Humans
  26. Smith IJ, Aversa Z, Alamdari N, Petkova V, Hasselgren PO. Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle. J Cell Biochem. 2010 Nov 01; 111(4):1059-73. PMID: 20677217.
    Citations: 11     Fields:    Translation:AnimalsCells
  27. Menconi MJ, Arany ZP, Alamdari N, Aversa Z, Gonnella P, O'Neal P, Smith IJ, Tizio S, Hasselgren PO. Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle. Am J Physiol Endocrinol Metab. 2010 Oct; 299(4):E533-43. PMID: 20647557.
    Citations: 11     Fields:    Translation:AnimalsCells
  28. Hasselgren PO, Alamdari N, Aversa Z, Gonnella P, Smith IJ, Tizio S. Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation. Curr Opin Clin Nutr Metab Care. 2010 Jul; 13(4):423-8. PMID: 20473154.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  29. Alamdari N, Smith IJ, Aversa Z, Hasselgren PO. Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Aug; 299(2):R509-20. PMID: 20538901.
    Citations: 26     Fields:    Translation:AnimalsCells
  30. Itagaki K, Menconi M, Antoniu B, Zhang Q, Gonnella P, Soybel D, Hauser C, Hasselgren PO. Dexamethasone stimulates store-operated calcium entry and protein degradation in cultured L6 myotubes through a phospholipase A(2)-dependent mechanism. Am J Physiol Cell Physiol. 2010 May; 298(5):C1127-39. PMID: 20107037.
    Citations: 12     Fields:    Translation:AnimalsCells
  31. Smith IJ, Alamdari N, O'Neal P, Gonnella P, Aversa Z, Hasselgren PO. Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism. Int J Biochem Cell Biol. 2010 May; 42(5):701-11. PMID: 20079455.
    Citations: 42     Fields:    Translation:AnimalsCells
  32. O'Neal P, Alamdari N, Smith I, Poylin V, Menconi M, Hasselgren PO. Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle. J Cell Biochem. 2009 Nov 01; 108(4):963-73. PMID: 19777444.
    Citations: 3     Fields:    Translation:AnimalsCells
  33. O'Neal PB, Poylin V, Mowschenson P, Parangi S, Horowitz G, Pant P, Hasselgren PO. When initial postexcision PTH level does not fall appropriately during parathyroidectomy: what to do next? World J Surg. 2009 Aug; 33(8):1665-73. PMID: 19495864.
    Citations: 1     Fields:    Translation:Humans
  34. Goldfarb M, O'Neal P, Shih JL, Hartzband P, Connolly J, Hasselgren PO. Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. Endocr Pract. 2009 Jul-Aug; 15(5):463-8. PMID: 19491068.
    Citations: 11     Fields:    Translation:Humans
  35. Alamdari N, O'Neal P, Hasselgren PO. Curcumin and muscle wasting: a new role for an old drug? Nutrition. 2009 Feb; 25(2):125-9. PMID: 19028079.
    Citations: 22     Fields:    Translation:HumansAnimals
  36. Menconi M, Gonnella P, Petkova V, Lecker S, Hasselgren PO. Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes. J Cell Biochem. 2008 Oct 01; 105(2):353-64. PMID: 18615595.
    Citations: 77     Fields:    Translation:AnimalsCells
  37. Smith IJ, Lecker SH, Hasselgren PO. Calpain activity and muscle wasting in sepsis. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E762-71. PMID: 18492780.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  38. Poylin V, Fareed MU, O'Neal P, Alamdari N, Reilly N, Menconi M, Hasselgren PO. The NF-kappaB inhibitor curcumin blocks sepsis-induced muscle proteolysis. Mediators Inflamm. 2008; 2008:317851. PMID: 18389075.
    Citations: 15     Fields:    Translation:AnimalsCells
  39. Hasselgren PO. Ubiquitination, phosphorylation, and acetylation--triple threat in muscle wasting. J Cell Physiol. 2007 Dec; 213(3):679-89. PMID: 17657723.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  40. Menconi M, Fareed M, O'Neal P, Poylin V, Wei W, Hasselgren PO. Role of glucocorticoids in the molecular regulation of muscle wasting. Crit Care Med. 2007 Sep; 35(9 Suppl):S602-8. PMID: 17713416.
    Citations: 33     Fields:    Translation:HumansAnimals
  41. Fang CH, Li B, James JH, Yahya A, Kadeer N, Guo X, Xiao C, Supp DM, Kagan RJ, Hasselgren PO, Sheriff S. GSK-3beta activity is increased in skeletal muscle after burn injury in rats. Am J Physiol Regul Integr Comp Physiol. 2007 Oct; 293(4):R1545-51. PMID: 17686886.
    Citations: 13     Fields:    Translation:AnimalsCells
  42. Reilly N, Poylin V, Menconi M, Onderdonk A, Bengmark S, Hasselgren PO. Probiotics potentiate IL-6 production in IL-1beta-treated Caco-2 cells through a heat shock-dependent mechanism. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1169-79. PMID: 17634198.
    Citations: 15     Fields:    Translation:HumansCells
  43. Evenson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S, Hasselgren PO. Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg. 2007 Jun; 193(6):707-12. PMID: 17512281.
    Citations: 5     Fields:    Translation:Humans
  44. Wei W, Yang H, Menconi M, Cao P, Chamberlain CE, Hasselgren PO. Treatment of cultured myotubes with the proteasome inhibitor beta-lactone increases the expression of the transcription factor C/EBPbeta. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C216-26. PMID: 16987992.
    Citations: 3     Fields:    Translation:AnimalsCells
  45. Yang H, Wei W, Menconi M, Hasselgren PO. Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent. Am J Physiol Regul Integr Comp Physiol. 2007 Jan; 292(1):R337-4. PMID: 16973938.
    Citations: 19     Fields:    Translation:AnimalsCells
  46. Evenson A, Mitchell J, Wei W, Poylin V, Parangi S, Hasselgren PO. The gene expression and activity of calpains and the muscle wasting-associated ubiquitin ligases, atrogin-1 and MuRF1, are not altered in patients with primary hyperparathyroidism. Int J Mol Med. 2006 Sep; 18(3):471-5. PMID: 16865232.
    Citations: 1     Fields:    Translation:Humans
  47. Wei W, Yang H, Cao P, Menconi M, Chamberlain C, Petkova V, Hasselgren PO. Degradation of C/EBPbeta in cultured myotubes is calpain-dependent. J Cell Physiol. 2006 Aug; 208(2):386-98. PMID: 16646084.
    Citations: 10     Fields:    Translation:AnimalsCells
  48. Fareed MU, Evenson AR, Wei W, Menconi M, Poylin V, Petkova V, Pignol B, Hasselgren PO. Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. Am J Physiol Regul Integr Comp Physiol. 2006 Jun; 290(6):R1589-97. PMID: 16455766.
    Citations: 51     Fields:    Translation:AnimalsCells
  49. Mitchell JC, Grant F, Evenson AR, Parker JA, Hasselgren PO, Parangi S. Preoperative evaluation of thyroid nodules with 18FDG-PET/CT. Surgery. 2005 Dec; 138(6):1166-74; discussion 1174-5. PMID: 16360405.
    Citations: 26     Fields:    Translation:Humans