Harvard Catalyst Profiles

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Per-Olof Hasselgren, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NR008545 (HASSELGREN, PER-OLOF J) Sep 30, 2004 - Aug 31, 2009
    NIH
    C/EBP, atrogin-1, and muscle wasting
    Role: Principal Investigator
  2. R56NR008545 (HASSELGREN, PER-OLOF J) Jul 1, 2003 - Aug 31, 2010
    NIH
    C/EBP, atrogin-1, and muscle wasting
    Role: Principal Investigator
  3. R01DK060546 (HASSELGREN, PER-OLOF J) May 1, 2003 - Feb 28, 2008
    NIH
    C/EBP and IL-6 Production in Mucosa and Enterocytes
    Role: Principal Investigator
  4. R01DK044201 (HASSELGREN, PER-OLOF J) Apr 1, 1992 - Mar 31, 1995
    NIH
    INTESTINAL PROTEIN METABOLISM IN SEPSIS
    Role: Principal Investigator
  5. R01DK040644 (HASSELGREN, PER-OLOF J) Sep 1, 1988 - Aug 31, 1991
    NIH
    PROTEIN SYNTHESIS IN LIVER DURING SEPSIS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li C, Lopez B, Fligor S, Broekhuis JM, Maeda A, Duncan S, Chen HW, Choudhary A, Budwani S, Hasselgren PO, Mowschenson P, Mallur PS, James BC. Long-term voice changes after thyroidectomy: Results from a validated survey. Surgery. 2021 Jul 31. PMID: 34344524.
    Citations:    Fields:    
  2. Higgins S, James BC, Sacks B, Mowschenson P, Nishino M, Hasselgren PO. Can Cytologic and Sonographic Features Help Prevent Overtreatment of Bethesda V Thyroid Nodules? J Surg Res. 2021 Jul 20; 268:112-118. PMID: 34298210.
    Citations:    Fields:    
  3. Nishino M, Mateo R, Kilim H, Feldman A, Elliott A, Shen C, Hasselgren PO, Wang H, Hartzband P, Hennessey JV. Repeat Fine Needle Aspiration Cytology Refines the Selection of Thyroid Nodules for Afirma Gene Expression Classifier Testing. Thyroid. 2021 08; 31(8):1253-1263. PMID: 33813868.
    Citations:    Fields:    
  4. Hasselgren PO. The Smallpox Epidemics in America in the 1700s and the Role of the Surgeons: Lessons to be Learned During the Global Outbreak of COVID-19. World J Surg. 2020 09; 44(9):2837-2841. PMID: 32623571.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  5. Roth EM, Barrows CE, Nishino M, Sacks B, Hasselgren PO, James BC. Papillary thyroid cancer with extrathyroidal extension of desmoid-type fibromatosis. A case report of an aggressive presentation of an uncommon pathologic entity. Int J Surg Case Rep. 2019; 63:5-9. PMID: 31499326.
    Citations: 2     
  6. Mehrzad R, Nishino M, Nucera C, Dias-Santagata D, Hennessey JV, Hasselgren PO. Invasive follicular variant of papillary thyroid cancer harboring the NRAS mutation Q61K and presenting with bone metastasis-A case report. Int J Surg Case Rep. 2017; 38:180-184. PMID: 28780248.
    Citations: 1     
  7. Gavrila A, Hasselgren PO, Glasgow A, Doyle AN, Lee AJ, Fox P, Gautam S, Hennessey JV, Kolodny GM, Cypess AM. Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status. Thyroid. 2017 01; 27(1):1-10. PMID: 27750020.
    Citations: 10     Fields:    Translation:Humans
  8. Mehrzad R, Nishino M, Connolly J, Wang H, Mowschenson P, Hasselgren PO. The relationship between the follicular variant of papillary thyroid cancer and follicular adenomas. Surgery. 2016 May; 159(5):1396-406. PMID: 26782349.
    Citations: 7     Fields:    Translation:Humans
  9. Moon HS, Huh JY, Dincer F, Schneider BE, Hasselgren PO, Mantzoros CS. Identification and saturable nature of signaling pathways induced by metreleptin in humans: comparative evaluation of in vivo, ex vivo, and in vitro administration. Diabetes. 2015 Mar; 64(3):828-39. PMID: 25249580.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  10. Hasselgren PO. ß-Hydroxy-ß-methylbutyrate (HMB) and prevention of muscle wasting. Metabolism. 2014 Jan; 63(1):5-8. PMID: 24140096.
    Citations: 4     Fields:    Translation:Animals
  11. Castillero E, Alamdari N, Lecker SH, Hasselgren PO. Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes. Metabolism. 2013 Oct; 62(10):1495-502. PMID: 23866982.
    Citations: 16     Fields:    Translation:AnimalsCells
  12. Aversa Z, Alamdari N, Castillero E, Muscaritoli M, Rossi Fanelli F, Hasselgren PO. CaMKII activity is reduced in skeletal muscle during sepsis. J Cell Biochem. 2013 Jun; 114(6):1294-305. PMID: 23238742.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med. 2013 May; 19(5):635-9. PMID: 23603815.
    Citations: 277     Fields:    Translation:HumansAnimalsCells
  14. Castillero E, Alamdari N, Aversa Z, Gurav A, Hasselgren PO. PPARß/d regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting. PLoS One. 2013; 8(3):e59726. PMID: 23555761.
    Citations: 14     Fields:    Translation:AnimalsCells
  15. Alamdari N, Toraldo G, Aversa Z, Smith I, Castillero E, Renaud G, Qaisar R, Larsson L, Jasuja R, Hasselgren PO. Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness. . 2012 Nov 15; 303(10):R1090-9. PMID: 23019215.
    Citations: 4     Translation:AnimalsCells
  16. Aversa Z, Alamdari N, Castillero E, Muscaritoli M, Rossi Fanelli F, Hasselgren PO. ß-Hydroxy-ß-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy. Biochem Biophys Res Commun. 2012 Jul 13; 423(4):739-43. PMID: 22705301.
    Citations: 18     Fields:    Translation:AnimalsCells
  17. Alamdari N, Aversa Z, Castillero E, Hasselgren PO. Acetylation and deacetylation--novel factors in muscle wasting. Metabolism. 2013 Jan; 62(1):1-11. PMID: 22626763.
    Citations: 16     Fields:    Translation:HumansCells
  18. Alamdari N, Hasselgren PO. Comment on Sirtuin 1 in skeletal muscle of cachectic tumour-bearing rats. J Cachexia Sarcopenia Muscle. 2012 Mar; 3(1):71-2. PMID: 22450731.
    Citations:    Fields:    
  19. Chamberlain W, Gonnella P, Alamdari N, Aversa Z, Hasselgren PO. Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells. Biochem Cell Biol. 2012 Apr; 90(2):200-8. PMID: 22292478.
    Citations: 6     Fields:    Translation:AnimalsCells
  20. Alamdari N, Aversa Z, Castillero E, Gurav A, Petkova V, Tizio S, Hasselgren PO. Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism. Biochem Biophys Res Commun. 2012 Jan 06; 417(1):528-33. PMID: 22166204.
    Citations: 30     Fields:    Translation:AnimalsCells
  21. Gonnella P, Alamdari N, Tizio S, Aversa Z, Petkova V, Hasselgren PO. C/EBPß regulates dexamethasone-induced muscle cell atrophy and expression of atrogin-1 and MuRF1. J Cell Biochem. 2011 Jul; 112(7):1737-48. PMID: 21381078.
    Citations: 9     Fields:    Translation:AnimalsCells
  22. Aversa Z, Alamdari N, Hasselgren PO. Molecules modulating gene transcription during muscle wasting in cancer, sepsis, and other critical illness. Crit Rev Clin Lab Sci. 2011 Mar-Apr; 48(2):71-86. PMID: 21871000.
    Citations: 4     Fields:    Translation:HumansCells
  23. Smith IJ, Aversa Z, Hasselgren PO, Pacelli F, Rosa F, Doglietto GB, Bossola M. Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. Muscle Nerve. 2011 Mar; 43(3):410-4. PMID: 21305563.
    Citations: 12     Fields:    Translation:HumansCells
  24. O'Neal P, Mowschenson P, Connolly J, Hasselgren PO. Large parathyroid tumors have an increased risk of atypia and carcinoma. Am J Surg. 2011 Aug; 202(2):146-50. PMID: 21256474.
    Citations: 6     Fields:    Translation:Humans
  25. Smith IJ, Aversa Z, Alamdari N, Petkova V, Hasselgren PO. Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle. J Cell Biochem. 2010 Nov 01; 111(4):1059-73. PMID: 20677217.
    Citations: 10     Fields:    Translation:AnimalsCells
  26. Menconi MJ, Arany ZP, Alamdari N, Aversa Z, Gonnella P, O'Neal P, Smith IJ, Tizio S, Hasselgren PO. Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle. Am J Physiol Endocrinol Metab. 2010 Oct; 299(4):E533-43. PMID: 20647557.
    Citations: 10     Fields:    Translation:AnimalsCells
  27. Hasselgren PO, Alamdari N, Aversa Z, Gonnella P, Smith IJ, Tizio S. Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation. Curr Opin Clin Nutr Metab Care. 2010 Jul; 13(4):423-8. PMID: 20473154.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  28. Alamdari N, Smith IJ, Aversa Z, Hasselgren PO. Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. . 2010 Aug; 299(2):R509-20. PMID: 20538901.
    Citations: 22     Translation:AnimalsCells
  29. Itagaki K, Menconi M, Antoniu B, Zhang Q, Gonnella P, Soybel D, Hauser C, Hasselgren PO. Dexamethasone stimulates store-operated calcium entry and protein degradation in cultured L6 myotubes through a phospholipase A(2)-dependent mechanism. . 2010 May; 298(5):C1127-39. PMID: 20107037.
    Citations: 10     Translation:AnimalsCells
  30. Smith IJ, Alamdari N, O'Neal P, Gonnella P, Aversa Z, Hasselgren PO. Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism. Int J Biochem Cell Biol. 2010 May; 42(5):701-11. PMID: 20079455.
    Citations: 42     Fields:    Translation:AnimalsCells
  31. O'Neal P, Alamdari N, Smith I, Poylin V, Menconi M, Hasselgren PO. Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle. J Cell Biochem. 2009 Nov 01; 108(4):963-73. PMID: 19777444.
    Citations: 2     Fields:    Translation:AnimalsCells
  32. O'Neal PB, Poylin V, Mowschenson P, Parangi S, Horowitz G, Pant P, Hasselgren PO. When initial postexcision PTH level does not fall appropriately during parathyroidectomy: what to do next? World J Surg. 2009 Aug; 33(8):1665-73. PMID: 19495864.
    Citations: 1     Fields:    Translation:Humans
  33. Goldfarb M, O'Neal P, Shih JL, Hartzband P, Connolly J, Hasselgren PO. Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. Endocr Pract. 2009 Jul-Aug; 15(5):463-8. PMID: 19491068.
    Citations: 9     Fields:    Translation:Humans
  34. Alamdari N, O'Neal P, Hasselgren PO. Curcumin and muscle wasting: a new role for an old drug? Nutrition. 2009 Feb; 25(2):125-9. PMID: 19028079.
    Citations: 17     Fields:    Translation:HumansAnimals
  35. Menconi M, Gonnella P, Petkova V, Lecker S, Hasselgren PO. Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes. J Cell Biochem. 2008 Oct 01; 105(2):353-64. PMID: 18615595.
    Citations: 68     Fields:    Translation:AnimalsCells
  36. Smith IJ, Lecker SH, Hasselgren PO. Calpain activity and muscle wasting in sepsis. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E762-71. PMID: 18492780.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  37. Poylin V, Fareed MU, O'Neal P, Alamdari N, Reilly N, Menconi M, Hasselgren PO. The NF-kappaB inhibitor curcumin blocks sepsis-induced muscle proteolysis. Mediators Inflamm. 2008; 2008:317851. PMID: 18389075.
    Citations: 14     Fields:    Translation:AnimalsCells
  38. Hasselgren PO. Ubiquitination, phosphorylation, and acetylation--triple threat in muscle wasting. J Cell Physiol. 2007 Dec; 213(3):679-89. PMID: 17657723.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  39. Menconi M, Fareed M, O'Neal P, Poylin V, Wei W, Hasselgren PO. Role of glucocorticoids in the molecular regulation of muscle wasting. Crit Care Med. 2007 Sep; 35(9 Suppl):S602-8. PMID: 17713416.
    Citations: 30     Fields:    Translation:HumansAnimals
  40. Fang CH, Li B, James JH, Yahya A, Kadeer N, Guo X, Xiao C, Supp DM, Kagan RJ, Hasselgren PO, Sheriff S. GSK-3beta activity is increased in skeletal muscle after burn injury in rats. . 2007 Oct; 293(4):R1545-51. PMID: 17686886.
    Citations: 12     Translation:AnimalsCells
  41. Reilly N, Poylin V, Menconi M, Onderdonk A, Bengmark S, Hasselgren PO. Probiotics potentiate IL-6 production in IL-1beta-treated Caco-2 cells through a heat shock-dependent mechanism. . 2007 Sep; 293(3):R1169-79. PMID: 17634198.
    Citations: 13     Translation:HumansCells
  42. Evenson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S, Hasselgren PO. Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg. 2007 Jun; 193(6):707-12. PMID: 17512281.
    Citations: 4     Fields:    Translation:Humans
  43. Wei W, Yang H, Menconi M, Cao P, Chamberlain CE, Hasselgren PO. Treatment of cultured myotubes with the proteasome inhibitor beta-lactone increases the expression of the transcription factor C/EBPbeta. . 2007 Jan; 292(1):C216-26. PMID: 16987992.
    Citations: 3     Translation:AnimalsCells
  44. Yang H, Wei W, Menconi M, Hasselgren PO. Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent. . 2007 Jan; 292(1):R337-4. PMID: 16973938.
    Citations: 16     Translation:AnimalsCells
  45. Evenson A, Mitchell J, Wei W, Poylin V, Parangi S, Hasselgren PO. The gene expression and activity of calpains and the muscle wasting-associated ubiquitin ligases, atrogin-1 and MuRF1, are not altered in patients with primary hyperparathyroidism. Int J Mol Med. 2006 Sep; 18(3):471-5. PMID: 16865232.
    Citations: 1     Fields:    Translation:Humans
  46. Wei W, Yang H, Cao P, Menconi M, Chamberlain C, Petkova V, Hasselgren PO. Degradation of C/EBPbeta in cultured myotubes is calpain-dependent. J Cell Physiol. 2006 Aug; 208(2):386-98. PMID: 16646084.
    Citations: 9     Fields:    Translation:AnimalsCells
  47. Fareed MU, Evenson AR, Wei W, Menconi M, Poylin V, Petkova V, Pignol B, Hasselgren PO. Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. . 2006 Jun; 290(6):R1589-97. PMID: 16455766.
    Citations: 48     Translation:AnimalsCells
  48. Mitchell JC, Grant F, Evenson AR, Parker JA, Hasselgren PO, Parangi S. Preoperative evaluation of thyroid nodules with 18FDG-PET/CT. Surgery. 2005 Dec; 138(6):1166-74; discussion 1174-5. PMID: 16360405.
    Citations: 25     Fields:    Translation:Humans
  49. Evenson AR, Fareed MU, Menconi MJ, Mitchell JC, Hasselgren PO. GSK-3beta inhibitors reduce protein degradation in muscles from septic rats and in dexamethasone-treated myotubes. Int J Biochem Cell Biol. 2005 Oct; 37(10):2226-38. PMID: 16051512.
    Citations: 21     Fields:    Translation:AnimalsCells
  50. Li BG, Hasselgren PO, Fang CH. Insulin-like growth factor-I inhibits dexamethasone-induced proteolysis in cultured L6 myotubes through PI3K/Akt/GSK-3beta and PI3K/Akt/mTOR-dependent mechanisms. Int J Biochem Cell Biol. 2005 Oct; 37(10):2207-16. PMID: 15927518.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  51. Yang H, Mammen J, Wei W, Menconi M, Evenson A, Fareed M, Petkova V, Hasselgren PO. Expression and activity of C/EBPbeta and delta are upregulated by dexamethasone in skeletal muscle. J Cell Physiol. 2005 Jul; 204(1):219-26. PMID: 15669083.
    Citations: 28     Fields:    Translation:AnimalsCells
  52. Yang H, Menconi MJ, Wei W, Petkova V, Hasselgren PO. Dexamethasone upregulates the expression of the nuclear cofactor p300 and its interaction with C/EBPbeta in cultured myotubes. J Cell Biochem. 2005 Apr 01; 94(5):1058-67. PMID: 15669015.
    Citations: 19     Fields:    Translation:AnimalsCells
  53. Fang CH, Li BG, James JH, King JK, Evenson AR, Warden GD, Hasselgren PO. Protein breakdown in muscle from burned rats is blocked by insulin-like growth factor i and glycogen synthase kinase-3beta inhibitors. Endocrinology. 2005 Jul; 146(7):3141-9. PMID: 15802492.
    Citations: 19     Fields:    Translation:AnimalsCells
  54. Hasselgren PO, Menconi MJ, Fareed MU, Yang H, Wei W, Evenson A. Novel aspects on the regulation of muscle wasting in sepsis. Int J Biochem Cell Biol. 2005 Oct; 37(10):2156-68. PMID: 16125115.
    Citations: 21     Fields:    Translation:Humans
  55. Wei W, Fareed MU, Evenson A, Menconi MJ, Yang H, Petkova V, Hasselgren PO. Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3. . 2005 Mar; 288(3):R580-90. PMID: 15563579.
    Citations: 26     Translation:AnimalsCells
  56. Cai D, Frantz JD, Tawa NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 2004 Oct 15; 119(2):285-98. PMID: 15479644.
    Citations: 475     Fields:    Translation:HumansAnimalsCells
  57. Menconi MJ, Wei W, Yang H, Wray CJ, Hasselgren PO. Treatment of cultured myotubes with the calcium ionophore A23187 increases proteasome activity via a CaMK II-caspase-calpain-dependent mechanism. Surgery. 2004 Aug; 136(2):135-42. PMID: 15300172.
    Citations: 8     Fields:    Translation: