Harvard Catalyst Profiles

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Eric Garland Sheu, M.D., D.Phil.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01 DK126855 (SHEU, ERIC GARLAND) Jan 8, 2021 - Dec 31, 2025
    A microbiome-dependent bile acid metabolite improves type 2 diabetes
    Role: Principal Investigator
  2. F32GM084639 (SHEU, ERIC GARLAND) Jun 1, 2008 - May 31, 2010
    Identification of human natural IgM that mediate ischemia-reperfusion injury
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Aly S, Sheu EG. Comment on: Glycemic outcomes in patients with type 2 diabetes after bariatric surgery compared with routine care: a population-based, real-world cohort study in the United Kingdom. Surg Obes Relat Dis. 2022 12; 18(12):1376-1377. PMID: 36224081.
    Citations:    Fields:    Translation:Humans
  2. Roberts CF, Sheu EG. Low density, high impact? Neutrophil changes in obesity and bariatric surgery. EBioMedicine. 2022 05; 79:103988. PMID: 35405386; PMCID: PMC9014355.
    Citations:    Fields:    Translation:HumansCells
  3. Lo T, Haridas RS, Rudge EJM, Chase RP, Heshmati K, Lucey EM, Weigl AM, Iyoha-Bello OJ, Ituah CO, Benjamin EJ, McNutt SW, Sathe L, Farnam L, Raby BA, Tavakkoli A, Croteau-Chonka DC, Sheu EG. Early Changes in Immune Cell Count, Metabolism, and Function Following Sleeve Gastrectomy: A Prospective Human Study. J Clin Endocrinol Metab. 2022 01 18; 107(2):e619-e630. PMID: 34514501; PMCID: PMC8764221.
    Citations: 2     Fields:    Translation:HumansCells
  4. Senturk JC, Sharma R, Tavakkoli A, Vernon A, Spector D, Robinson M, Sheu E, Shikora S. Safety and effectiveness of 1-stage conversion of adjustable gastric band-to-sleeve gastrectomy: a single-institution case-control study. Surg Obes Relat Dis. 2022 Jan; 18(1):95-101. PMID: 34666948.
    Citations:    Fields:    Translation:Humans
  5. Quante M, Iske J, Heinbokel T, Desai BN, Cetina Biefer HR, Nian Y, Krenzien F, Matsunaga T, Uehara H, Maenosono R, Azuma H, Pratschke J, Falk CS, Lo T, Sheu E, Tavakkoli A, Abdi R, Perkins D, Alegre ML, Banks AS, Zhou H, Elkhal A, Tullius SG. Restored TDCA and valine levels imitate the effects of bariatric surgery. Elife. 2021 06 22; 10. PMID: 34155969.
    Citations:    Fields:    Translation:Animals
  6. Edgerton C, Heshmati K, Herman A, Dey T, Dehkharghani R, Ramsis R, Robinson M, Vernon A, Ghushe N, Spector D, Shikora S, Tavakkoli A, Sheu EG. Fellowship training influences learning curves for laparoscopic sleeve gastrectomy. Surg Endosc. 2022 02; 36(2):1601-1608. PMID: 33620566.
    Citations:    Fields:    Translation:Humans
  7. Mahvi DA, Foley OW, Ardestani A, Tavakkoli A, Sheu EG. Impact of Bariatric Surgery on Endometrial Cancer Tumor Pathology. Obes Surg. 2021 06; 31(6):2426-2433. PMID: 33604865.
    Citations:    Fields:    Translation:Humans
  8. Harris DA, Subramaniam R, Brenner T, Tavakkoli A, Sheu EG. Weight and organ specific immune cell profiling of sleeve gastrectomy in mice. Metabolism. 2021 05; 118:154729. PMID: 33607195.
    Citations: 2     Fields:    Translation:Animals
  9. Chaudhari SN, Luo JN, Harris DA, Aliakbarian H, Yao L, Paik D, Subramaniam R, Adhikari AA, Vernon AH, Kiliç A, Weiss ST, Huh JR, Sheu EG, Devlin AS. A microbial metabolite remodels the gut-liver axis following bariatric surgery. Cell Host Microbe. 2021 03 10; 29(3):408-424.e7. PMID: 33434516; PMCID: PMC7954942.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  10. Lo T, Rudge EJM, Chase RP, Subramaniam R, Heshmati K, Lucey EM, Weigl AM, Iyoha-Bello OJ, Ituah CO, Benjamin EJ, McNutt SW, Sathe L, Farnam L, Raby BA, Tavakkoli A, Croteau-Chonka DC, Sheu EG. Early changes in immune cell metabolism and function are a hallmark of sleeve gastrectomy: a prospective human study. medRxiv. 2020 Nov 03. PMID: 33173925; PMCID: PMC7654921.
  11. Chaudhari SN, Harris DA, Aliakbarian H, Luo JN, Henke MT, Subramaniam R, Vernon AH, Tavakkoli A, Sheu EG, Devlin AS. Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects. Nat Chem Biol. 2021 01; 17(1):20-29. PMID: 32747812; PMCID: PMC7891870.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  12. Aliakbarian H, Bhutta HY, Heshmati K, Unes Kunju S, Sheu EG, Tavakkoli A. Pre-operative Predictors of Weight Loss and Weight Regain Following Roux-en-Y Gastric Bypass Surgery: a Prospective Human Study. Obes Surg. 2020 12; 30(12):4852-4859. PMID: 32748203.
    Citations: 2     Fields:    Translation:Humans
  13. Luo JN, Sheu EG. Do Serum Metabolites Predict Weight Regain Following Bariatric Surgery? Dig Dis Sci. 2020 04; 65(4):922-924. PMID: 31435859.
    Citations: 1     Fields:    Translation:Humans
  14. Harris DA, Mina A, Cabarkapa D, Heshmati K, Subramaniam R, Banks AS, Tavakkoli A, Sheu EG. Sleeve gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss. Am J Physiol Endocrinol Metab. 2020 05 01; 318(5):E678-E688. PMID: 32069072.
    Citations: 5     Fields:    Translation:Animals
  15. Subramaniam R, Aliakbarian H, Bhutta HY, Harris DA, Tavakkoli A, Sheu EG. Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Attenuate Pro-inflammatory Small Intestinal Cytokine Signatures. Obes Surg. 2019 12; 29(12):3824-3832. PMID: 31363962.
    Citations: 6     Fields:    Translation:AnimalsCells
  16. Heshmati K, Harris DA, Aliakbarian H, Tavakkoli A, Sheu EG. Comparison of early type 2 diabetes improvement after gastric bypass and sleeve gastrectomy: medication cessation at discharge predicts 1-year outcomes. Surg Obes Relat Dis. 2019 Dec; 15(12):2025-2032. PMID: 31711946.
    Citations: 5     Fields:    Translation:Humans
  17. Heshmati K, Harris DA, Rosner B, Pranckevicius E, Ardestani A, Cho N, Golshan M, Ng WT, Ligibel J, Tavakkoli A, Sheu E. Association of Bariatric Surgery Status with Reduced HER2+ Breast Cancers: a Retrospective Cohort Study. Obes Surg. 2019 04; 29(4):1092-1098. PMID: 30659466.
    Citations: 3     Fields:    Translation:Humans
  18. Heshmati K, Lo T, Tavakkoli A, Sheu E. Short-Term Outcomes of Inflammatory Bowel Disease after Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy. J Am Coll Surg. 2019 06; 228(6):893-901.e1. PMID: 30797083.
    Citations: 5     Fields:    Translation:Humans
  19. Fallahian F, Ardestani A, Pranckevicius E, Raut CP, Tavakkoli A, Sheu EG. The impact of lipomatous tumors on type 2 diabetes: are adipose-derived tumors metabolically active? J Surg Res. 2018 02; 222:48-54. PMID: 29273375.
    Citations: 1     Fields:    Translation:Humans
  20. Pernar LIM, Robertson FC, Tavakkoli A, Sheu EG, Brooks DC, Smink DS. An appraisal of the learning curve in robotic general surgery. Surg Endosc. 2017 11; 31(11):4583-4596. PMID: 28411345.
    Citations: 22     Fields:    Translation:Humans
  21. Rudge EJM, Sheu EG. Bariatric Surgery for Autoimmunity? JAMA Surg. 2017 04 01; 152(4):349-350. PMID: 28002551.
    Citations: 3     Fields:    Translation:Humans
  22. Pernar LI, Mongiu A, Sheu EG. An Unusual Cause of Intestinal Perforation. JAMA Surg. 2017 02 01; 152(2):199-200. PMID: 27926750.
    Citations:    Fields:    Translation:Humans
  23. Ardestani A, Sheu EG, Nepomnayshy D, Rubin MS, Buchmiller TL, Jaklitsch MT, Tavakkoli A. Surgical skills competitions at ACS chapter meetings can increase resident engagement. Bull Am Coll Surg. 2016 May; 101(5):44-5. PMID: 27311235.
    Citations: 1     Fields:    
  24. Sheu EG, Wakatsuki K, Oakes S, Carroll MC, Moore FD. Prevention of intestinal ischemia-reperfusion injury in humanized mice. Surgery. 2016 08; 160(2):436-42. PMID: 27086922; PMCID: PMC4938717.
    Citations: 3     Fields:    Translation:AnimalsCells
  25. Sheu EG, Rattner DW. Evaluation of the LINX antireflux procedure. Curr Opin Gastroenterol. 2015 Jul; 31(4):334-8. PMID: 26039726.
    Citations: 4     Fields:    Translation:Humans
  26. Sheu EG, Channick R, Gee DW. Improvement in severe pulmonary hypertension in obese patients after laparoscopic gastric bypass or sleeve gastrectomy. Surg Endosc. 2016 Feb; 30(2):633-637. PMID: 26091991.
    Citations: 6     Fields:    Translation:Humans
  27. Sheu EG, Nau P, Nath B, Kuo B, Rattner DW. A comparative trial of laparoscopic magnetic sphincter augmentation and Nissen fundoplication. Surg Endosc. 2015 Mar; 29(3):505-9. PMID: 25012804.
    Citations: 19     Fields:    Translation:Humans
  28. Cho NL, Gawande AA, Sheu EG, Moore FD, Ruan DT. Critical role of identification of the second gland during unilateral parathyroid surgery: a prospective review of 119 patients with concordant localization. Arch Surg. 2011 May; 146(5):512-6. PMID: 21576603.
    Citations: 2     Fields:    Translation:Humans
  29. Afnan J, Ahmadi-Yazdi C, Sheu EG, Oakes SM, Moore FD. Inhibition of rat gut reperfusion injury with an agent developed for the mouse. Evidence that amplification of injury by innate immunity is conserved between two animal species. Am J Physiol Regul Integr Comp Physiol. 2010 Jun; 298(6):R1675-81. PMID: 20335374.
    Citations: 4     Fields:    Translation:Animals
  30. Sheu EG, Oakes SM, Ahmadi-Yazdi C, Afnan J, Carroll MC, Moore FD. Restoration of skeletal muscle ischemia-reperfusion injury in humanized immunodeficient mice. Surgery. 2009 Aug; 146(2):340-6. PMID: 19628094; PMCID: PMC2767199.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  31. Flanagan KL, Plebanski M, Odhiambo K, Sheu E, Mwangi T, Gelder C, Hart K, Kortok M, Lowe B, Robson KJ, Marsh K, Hill AV. Cellular reactivity to the p. Falciparum protein trap in adult kenyans: novel epitopes, complex cytokine patterns, and the impact of natural antigenic variation. Am J Trop Med Hyg. 2006 Mar; 74(3):367-75. PMID: 16525093.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  32. Korten S, Anderson RJ, Hannan CM, Sheu EG, Sinden R, Gadola S, Taniguchi M, Hill AV. Invariant Valpha14 chain NKT cells promote Plasmodium berghei circumsporozoite protein-specific gamma interferon- and tumor necrosis factor alpha-producing CD8+ T cells in the liver after poxvirus vaccination of mice. Infect Immun. 2005 Feb; 73(2):849-58. PMID: 15664925; PMCID: PMC546932.
    Citations: 9     Fields:    Translation:AnimalsCells
  33. Stern JN, Illés Z, Reddy J, Keskin DB, Sheu E, Fridkis-Hareli M, Nishimura H, Brosnan CF, Santambrogio L, Kuchroo VK, Strominger JL. Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11743-8. PMID: 15292514; PMCID: PMC511046.
    Citations: 18     Fields:    Translation:AnimalsCellsPHPublic Health
  34. Anderson RJ, Hannan CM, Gilbert SC, Laidlaw SM, Sheu EG, Korten S, Sinden R, Butcher GA, Skinner MA, Hill AV. Enhanced CD8+ T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus. J Immunol. 2004 Mar 01; 172(5):3094-100. PMID: 14978115.
    Citations: 39     Fields:    Translation:AnimalsCells
  35. Prieur E, Gilbert SC, Schneider J, Moore AC, Sheu EG, Goonetilleke N, Robson KJ, Hill AV. A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):290-5. PMID: 14694197; PMCID: PMC314178.
    Citations: 26     Fields:    Translation:AnimalsCells
  36. Flanagan KL, Mwangi T, Plebanski M, Odhiambo K, Ross A, Sheu E, Kortok M, Lowe B, Marsh K, Hill AV. Ex vivo interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of Plasmodium falciparum infection. Am J Trop Med Hyg. 2003 Apr; 68(4):421-30. PMID: 12875291.
    Citations: 23     Fields:    Translation:HumansCells
  37. Hill AV, Reece W, Gothard P, Moorthy V, Roberts M, Flanagan K, Plebanski M, Hannan C, Hu JT, Anderson R, Degano P, Schneider J, Prieur E, Sheu E, Gilbert SC. DNA-based vaccines for malaria: a heterologous prime-boost immunisation strategy. Dev Biol (Basel). 2000; 104:171-9. PMID: 11713817.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  38. Schneider J, Gilbert SC, Hannan CM, Dégano P, Prieur E, Sheu EG, Plebanski M, Hill AV. Induction of CD8+ T cells using heterologous prime-boost immunisation strategies. Immunol Rev. 1999 Aug; 170:29-38. PMID: 10566139.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  39. Polikandritou Lambros M, Sheu E, Lin JS, Pereira HA. Interaction of a synthetic peptide based on the neutrophil-derived antimicrobial protein CAP37 with dipalmitoyl-phosphatidylcholine membranes. Biochim Biophys Acta. 1997 Oct 23; 1329(2):285-90. PMID: 9371420.
    Citations:    Fields:    Translation:HumansCells
  40. Mandelboim O, Reyburn HT, Sheu EG, Vales-Gomez M, Davis DM, Pazmany L, Strominger JL. The binding site of NK receptors on HLA-C molecules. Immunity. 1997 Mar; 6(3):341-50. PMID: 9075934.
    Citations: 27     Fields:    Translation:HumansCells
  41. Reyburn H, Mandelboim O, Valés-Goméz M, Sheu EG, Pazmany L, Davis DM, Strominger JL. Human NK cells: their ligands, receptors and functions. Immunol Rev. 1997 Feb; 155:119-25. PMID: 9059887.
    Citations: 11     Fields:    Translation:HumansCells
  42. Mandelboim O, Davis DM, Reyburn HT, Valés-Gómez M, Sheu EG, Pazmany L, Strominger JL. Enhancement of class II-restricted T cell responses by costimulatory NK receptors for class I MHC proteins. Science. 1996 Dec 20; 274(5295):2097-100. PMID: 8953044.
    Citations: 21     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.