Harvard Catalyst Profiles

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William Bradley Ruzicka, M.D.


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  1. K08MH109759 (RUZICKA, WILLIAM B) Sep 14, 2016 - Aug 31, 2021
    Neuronal and circuitry specific chromatin dynamics in psychotic disorders
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Coyle JT, Ruzicka WB, Balu DT. Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse. Am J Psychiatry. 2020 12 01; 177(12):1119-1128. PMID: 33256439; PMCID: PMC8011846.
    Citations: 8     Fields:    Translation:HumansCells
  2. Ruzicka WB, Subburaju S, Coyle JT, Benes FM. Location matters: distinct DNA methylation patterns in GABAergic interneuronal populations from separate microcircuits within the human hippocampus. Hum Mol Genet. 2018 01 15; 27(2):254-265. PMID: 29106556; PMCID: PMC5886141.
    Citations: 4     Fields:    Translation:HumansCells
  3. Subburaju S, Coleman AJ, Cunningham MG, Ruzicka WB, Benes FM. Epigenetic Regulation of Glutamic Acid Decarboxylase 67 in a Hippocampal Circuit. Cereb Cortex. 2017 11 01; 27(11):5284-5293. PMID: 27733539; PMCID: PMC6411031.
    Citations: 5     Fields:    Translation:AnimalsCells
  4. Ruzicka WB, Subburaju S, Benes FM. Variability of DNA Methylation within Schizophrenia Risk Loci across Subregions of Human Hippocampus. Genes (Basel). 2017 May 15; 8(5). PMID: 28505127.
    Citations: 3     Fields:    
  5. Subburaju S, Coleman AJ, Ruzicka WB, Benes FM. Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model. Transl Psychiatry. 2016 Jan 26; 6:e723. PMID: 26812044; PMCID: PMC5068889.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  6. Ruzicka WB, Subburaju S, Benes FM. Circuit- and Diagnosis-Specific DNA Methylation Changes at ?-Aminobutyric Acid-Related Genes in Postmortem Human Hippocampus in Schizophrenia and Bipolar Disorder. JAMA Psychiatry. 2015 Jun; 72(6):541-51. PMID: 25738424; PMCID: PMC5547581.
    Citations: 48     Fields:    Translation:HumansCells
  7. Ruzicka WB. Epigenetic mechanisms in the pathophysiology of psychotic disorders. Harv Rev Psychiatry. 2015 May-Jun; 23(3):212-22. PMID: 25943315.
    Citations: 1     Fields:    Translation:Humans
  8. Dong E, Ruzicka WB, Grayson DR, Guidotti A. DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients. Schizophr Res. 2015 Sep; 167(1-3):35-41. PMID: 25476119; PMCID: PMC4451449.
    Citations: 40     Fields:    Translation:HumansCells
  9. Costa E, Chen Y, Dong E, Grayson DR, Kundakovic M, Maloku E, Ruzicka W, Satta R, Veldic M, Zhubi A, Guidotti A. GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability. Expert Rev Neurother. 2009 Jan; 9(1):87-98. PMID: 19102671.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  10. Costa E, Dong E, Grayson DR, Guidotti A, Ruzicka W, Veldic M. Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics. 2007 Jan-Mar; 2(1):29-36. PMID: 17965595.
    Citations: 35     Fields:    Translation:Humans
  11. Ruzicka WB, Zhubi A, Veldic M, Grayson DR, Costa E, Guidotti A. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Mol Psychiatry. 2007 Apr; 12(4):385-97. PMID: 17264840.
    Citations: 81     Fields:    Translation:HumansCells
  12. Guidotti A, Ruzicka W, Grayson DR, Veldic M, Pinna G, Davis JM, Costa E. S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis. Neuroreport. 2007 Jan 08; 18(1):57-60. PMID: 17259861.
    Citations: 41     Fields:    Translation:Humans
  13. Costa E, Dong E, Grayson DR, Ruzicka WB, Simonini MV, Veldic M, Guidotti A. Epigenetic targets in GABAergic neurons to treat schizophrenia. Adv Pharmacol. 2006; 54:95-117. PMID: 17175812.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  14. Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting P, Sharma R, Grayson DR, Costa E, Guidotti A. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):17095-100. PMID: 12481028; PMCID: PMC139275.
    Citations: 114     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.