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profileEric Steven Lander, D.Phil.

TitleProfessor of Systems Biology
InstitutionMassachusetts Institute of Technology
DepartmentSystems Biology
AddressWhitehead Institute/MIT Ctr for Genome R
Harvard Institute of Proteomics
320 Charles Street
Cambridge MA 02141
Phone617/252-1906
Fax617/258-0903
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
Exploring CD40 Ligand and Its Association to Severe P. Falciparum Malaria
Part Time/Continuation, 09/01/01 - 12/31/01

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
UM1HG008895     (LANDER, ERIC S)Jan 14, 2016 - Nov 30, 2019
NIH/NHGRI
Center for Common Disease Genetics
Role: Co-Principal Investigator

R25HG006682     (LANDER, ERIC S)Mar 13, 2012 - Aug 31, 2020
NIH/NHGRI
Achieving diversity in genomics: Research education for URM scientists
Role: Co-Principal Investigator

R03MH089663     (LANDER, ERIC S)Sep 30, 2009 - Sep 29, 2010
NIH/NIMH
High-throughput screening for small molecules with specific toxicity for breast c
Role: Principal Investigator

U54HG003067     (LANDER, ERIC S)Nov 10, 2003 - Oct 31, 2016
NIH/NHGRI
Large Scale Sequencing and Analysis of Genomes
Role: Co-Principal Investigator

U54HG002152     (LANDER, ERIC S)Sep 30, 1999 - Oct 31, 2003
NIH/NHGRI
SEQUENCING THE MOUSE GENOME
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Polak P, Kim J, Braunstein LZ, Karlic R, Haradhavala NJ, Tiao G, Rosebrock D, Livitz D, Kübler K, Mouw KW, Kamburov A, Maruvka YE, Leshchiner I, Lander ES, Golub TR, Zick A, Orthwein A, Lawrence MS, Batra RN, Caldas C, Haber DA, Laird PW, Shen H, Ellisen LW, D'Andrea AD, Chanock SJ, Foulkes WD, Getz G. A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. Nat Genet. 2017 Aug 21. PMID: 28825726.
    View in: PubMed
  2. Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F. Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Nature. 2017 Aug 17; 548(7667):343-346. PMID: 28792927.
    View in: PubMed
  3. Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017 Jul 13; 547(7662):217-221. PMID: 28678778.
    View in: PubMed
  4. Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, Centeno-Cruz F, Zerrweck C, Orozco L, Altshuler DM, Schreiber SL, Florez JC, Jacobs SBR, Lander ES. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell. 2017 Jun 29; 170(1):199-212.e20. PMID: 28666119.
    View in: PubMed
  5. Rheinbay E, Parasuraman P, Grimsby J, Tiao G, Engreitz JM, Kim J, Lawrence MS, Taylor-Weiner A, Rodriguez-Cuevas S, Rosenberg M, Hess J, Stewart C, Maruvka YE, Stojanov P, Cortes ML, Seepo S, Cibulskis C, Tracy A, Pugh TJ, Lee J, Zheng Z, Ellisen LW, Iafrate AJ, Boehm JS, Gabriel SB, Meyerson M, Golub TR, Baselga J, Hidalgo-Miranda A, Shioda T, Bernards A, Lander ES, Getz G. Recurrent and functional regulatory mutations in breast cancer. Nature. 2017 07 06; 547(7661):55-60. PMID: 28658208.
    View in: PubMed
  6. Tiao G, Improgo MR, Kasar S, Poh W, Kamburov A, Landau DA, Tausch E, Taylor-Weiner A, Cibulskis C, Bahl S, Fernandes SM, Hoang K, Rheinbay E, Kim HT, Bahlo J, Robrecht S, Fischer K, Hallek M, Gabriel S, Lander ES, Stilgenbauer S, Wu CJ, Kiezun A, Getz G, Brown JR. Rare germline variants in ATM are associated with chronic lymphocytic leukemia. Leukemia. 2017 Jun 27. PMID: 28652578.
    View in: PubMed
  7. Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartze DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer CJ, Abecasis GR, Saleheen D, Kubo M, Kato N, Ida Chen YD, Dewey FE, Kathiresan S. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res. 2017 Jun 23; 121(1):81-88. PMID: 28506971.
    View in: PubMed
  8. Mitt M, Kals M, Pärn K, Gabriel SB, Lander ES, Palotie A, Ripatti S, Morris AP, Metspalu A, Esko T, Mägi R, Palta P. Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. Eur J Hum Genet. 2017 Jun; 25(7):869-876. PMID: 28401899.
    View in: PubMed
  9. Saleheen D, Natarajan P, Armean IM, Zhao W, Rasheed A, Khetarpal SA, Won HH, Karczewski KJ, O'Donnell-Luria AH, Samocha KE, Weisburd B, Gupta N, Zaidi M, Samuel M, Imran A, Abbas S, Majeed F, Ishaq M, Akhtar S, Trindade K, Mucksavage M, Qamar N, Zaman KS, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Hayyat Mallick N, Ishaq M, Rasheed SZ, Memon FU, Mahmood K, Ahmed N, Do R, Krauss RM, MacArthur DG, Gabriel S, Lander ES, Daly MJ, Frossard P, Danesh J, Rader DJ, Kathiresan S. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 2017 04 12; 544(7649):235-239. PMID: 28406212.
    View in: PubMed
  10. Stitziel NO, Khera AV, Wang X, Bierhals AJ, Vourakis AC, Sperry AE, Natarajan P, Klarin D, Emdin CA, Zekavat SM, Nomura A, Erdmann J, Schunkert H, Samani NJ, Kraus WE, Shah SH, Yu B, Boerwinkle E, Rader DJ, Gupta N, Frossard PM, Rasheed A, Danesh J, Lander ES, Gabriel S, Saleheen D, Musunuru K, Kathiresan S. ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. J Am Coll Cardiol. 2017 Apr 25; 69(16):2054-2063. PMID: 28385496.
    View in: PubMed
  11. Dudchenko O, Batra SS, Omer AD, Nyquist SK, Hoeger M, Durand NC, Shamim MS, Machol I, Lander ES, Aiden AP, Aiden EL. De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds. Science. 2017 Apr 07; 356(6333):92-95. PMID: 28336562.
    View in: PubMed
  12. Kim AR, Ulirsch JC, Wilmes S, Unal E, Moraga I, Karakukcu M, Yuan D, Kazerounian S, Abdulhay NJ, King DS, Gupta N, Gabriel SB, Lander ES, Patiroglu T, Ozcan A, Ozdemir MA, Garcia KC, Piehler J, Gazda HT, Klein DE, Sankaran VG. Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell. 2017 Mar 09; 168(6):1053-1064.e15. PMID: 28283061.
    View in: PubMed
  13. Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA. 2017 03 07; 317(9):937-946. PMID: 28267856.
    View in: PubMed
  14. Wang T, Yu H, Hughes NW, Liu B, Kendirli A, Klein K, Chen WW, Lander ES, Sabatini DM. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Cell. 2017 Feb 23; 168(5):890-903.e15. PMID: 28162770.
    View in: PubMed
  15. Grossman SR, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, Tewhey R, Isakova A, Deplancke B, Bernstein BE, Mikkelsen TS, Lander ES. Systematic dissection of genomic features determining transcription factor binding and enhancer function. Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7):E1291-E1300. PMID: 28137873.
    View in: PubMed
  16. Guo MH, Nandakumar SK, Ulirsch JC, Zekavat SM, Buenrostro JD, Natarajan P, Salem RM, Chiarle R, Mitt M, Kals M, Pärn K, Fischer K, Milani L, Mägi R, Palta P, Gabriel SB, Metspalu A, Lander ES, Kathiresan S, Hirschhorn JN, Esko T, Sankaran VG. Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proc Natl Acad Sci U S A. 2017 Jan 17; 114(3):E327-E336. PMID: 28031487.
    View in: PubMed
  17. Emdin CA, Khera AV, Natarajan P, Klarin D, Won HH, Peloso GM, Stitziel NO, Nomura A, Zekavat SM, Bick AG, Gupta N, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Willer C, Abecasis GR, Felix JF, Vasan RS, Lander E, Rader DJ, Danesh J, Ardissino D, Gabriel S, Saleheen D, Kathiresan S. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J Am Coll Cardiol. 2016 Dec 27; 68(25):2761-2772. PMID: 28007139.
    View in: PubMed
  18. Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nat Genet. 2017 Feb; 49(2):193-203. PMID: 27992415.
    View in: PubMed
  19. Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman JS, Friedman N, Regev A. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell. 2016 Dec 15; 167(7):1853-1866.e17. PMID: 27984732.
    View in: PubMed
  20. Engreitz JM, Haines JE, Perez EM, Munson G, Chen J, Kane M, McDonel PE, Guttman M, Lander ES. Local regulation of gene expression by lncRNA promoters, transcription and splicing. Nature. 2016 11 17; 539(7629):452-455. PMID: 27783602.
    View in: PubMed
  21. Giannakis M, Mu XJ, Shukla SA, Qian ZR, Cohen O, Nishihara R, Bahl S, Cao Y, Amin-Mansour A, Yamauchi M, Sukawa Y, Stewart C, Rosenberg M, Mima K, Inamura K, Nosho K, Nowak JA, Lawrence MS, Giovannucci EL, Chan AT, Ng K, Meyerhardt JA, Van Allen EM, Getz G, Gabriel SB, Lander ES, Wu CJ, Fuchs CS, Ogino S, Garraway LA. Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma. Cell Rep. 2016 Oct 18; 17(4):1206. PMID: 27760322.
    View in: PubMed
  22. Fulco CP, Munschauer M, Anyoha R, Munson G, Grossman SR, Perez EM, Kane M, Cleary B, Lander ES, Engreitz JM. Systematic mapping of functional enhancer-promoter connections with CRISPR interference. Science. 2016 11 11; 354(6313):769-773. PMID: 27708057.
    View in: PubMed
  23. Darrow EM, Huntley MH, Dudchenko O, Stamenova EK, Durand NC, Sun Z, Huang SC, Sanborn AL, Machol I, Shamim M, Seberg AP, Lander ES, Chadwick BP, Aiden EL. Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture. Proc Natl Acad Sci U S A. 2016 Aug 02; 113(31):E4504-12. PMID: 27432957; PMCID: PMC4978254.
  24. Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stancáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, van der Schouw YT, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, de Angelis MH, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JCN, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Burtt NP, Mohlke KL, Meitinger T, Groop L, Abecasis G, Florez JC, Scott LJ, Morris AP, Kang HM, Boehnke M, Altshuler D, McCarthy MI. The genetic architecture of type 2 diabetes. Nature. 2016 08 04; 536(7614):41-47. PMID: 27398621; PMCID: PMC5034897 [Available on 02/04/17].
  25. Durand NC, Shamim MS, Machol I, Rao SS, Huntley MH, Lander ES, Aiden EL. Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments. Cell Syst. 2016 Jul; 3(1):95-8. PMID: 27467249.
    View in: PubMed
  26. Durand NC, Robinson JT, Shamim MS, Machol I, Mesirov JP, Lander ES, Aiden EL. Juicebox Provides a Visualization System for Hi-C Contact Maps with Unlimited Zoom. Cell Syst. 2016 Jul; 3(1):99-101. PMID: 27467250.
    View in: PubMed
  27. Yassour M, Vatanen T, Siljander H, Hämäläinen AM, Härkönen T, Ryhänen SJ, Franzosa EA, Vlamakis H, Huttenhower C, Gevers D, Lander ES, Knip M, Xavier RJ. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Sci Transl Med. 2016 Jun 15; 8(343):343ra81. PMID: 27306663; PMCID: PMC5032909 [Available on 06/15/17].
  28. Tewhey R, Kotliar D, Park DS, Liu B, Winnicki S, Reilly SK, Andersen KG, Mikkelsen TS, Lander ES, Schaffner SF, Sabeti PC. Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay. Cell. 2016 Jun 02; 165(6):1519-1529. PMID: 27259153; PMCID: PMC4957403 [Available on 06/02/17].
  29. Abudayyeh OO, Gootenberg JS, Konermann S, Joung J, Slaymaker IM, Cox DB, Shmakov S, Makarova KS, Semenova E, Minakhin L, Severinov K, Regev A, Lander ES, Koonin EV, Zhang F. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science. 2016 Aug 05; 353(6299):aaf5573. PMID: 27256883.
    View in: PubMed
  30. Burger JA, Landau DA, Taylor-Weiner A, Bozic I, Zhang H, Sarosiek K, Wang L, Stewart C, Fan J, Hoellenriegel J, Sivina M, Dubuc AM, Fraser C, Han Y, Li S, Livak KJ, Zou L, Wan Y, Konoplev S, Sougnez C, Brown JR, Abruzzo LV, Carter SL, Keating MJ, Davids MS, Wierda WG, Cibulskis K, Zenz T, Werner L, Dal Cin P, Kharchencko P, Neuberg D, Kantarjian H, Lander E, Gabriel S, O'Brien S, Letai A, Weitz DA, Nowak MA, Getz G, Wu CJ. Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition. Nat Commun. 2016 May 20; 7:11589. PMID: 27199251; PMCID: PMC4876453.
  31. Blumenstiel B, DeFelice M, Birsoy O, Bleyer AJ, Kmoch S, Carter TA, Gnirke A, Kidd K, Rehm HL, Ronco L, Lander ES, Gabriel S, Lennon NJ. Development and Validation of a Mass Spectrometry-Based Assay for the Molecular Diagnosis of Mucin-1 Kidney Disease. J Mol Diagn. 2016 Jul; 18(4):566-71. PMID: 27157321.
    View in: PubMed
  32. Giannakis M, Mu XJ, Shukla SA, Qian ZR, Cohen O, Nishihara R, Bahl S, Cao Y, Amin-Mansour A, Yamauchi M, Sukawa Y, Stewart C, Rosenberg M, Mima K, Inamura K, Nosho K, Nowak JA, Lawrence MS, Giovannucci EL, Chan AT, Ng K, Meyerhardt JA, Van Allen EM, Getz G, Gabriel SB, Lander ES, Wu CJ, Fuchs CS, Ogino S, Garraway LA. Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma. Cell Rep. 2016 Apr 14. PMID: 27149842.
    View in: PubMed
  33. Khera AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, Duga S, Bis JC, van Duijn CM, Cupples LA, Psaty B, Rader DJ, Danesh J, Schunkert H, McPherson R, Farrall M, Watkins H, Lander E, Wilson JG, Correa A, Boerwinkle E, Merlini PA, Ardissino D, Saleheen D, Gabriel S, Kathiresan S. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol. 2016 Jun 07; 67(22):2578-89. PMID: 27050191.
    View in: PubMed
  34. Wang T, Lander ES, Sabatini DM. Single Guide RNA Library Design and Construction. Cold Spring Harb Protoc. 2016 Mar 01; 2016(3):pdb.prot090803. PMID: 26933249; PMCID: PMC4804709.
  35. Wang T, Lander ES, Sabatini DM. Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens. Cold Spring Harb Protoc. 2016 Mar 01; 2016(3):pdb.top086892. PMID: 26933254; PMCID: PMC4804892.
  36. Wang T, Lander ES, Sabatini DM. Viral Packaging and Cell Culture for CRISPR-Based Screens. Cold Spring Harb Protoc. 2016 Mar 01; 2016(3):pdb.prot090811. PMID: 26933250; PMCID: PMC4804706.
  37. Yassour M, Lim MY, Yun HS, Tickle TL, Sung J, Song YM, Lee K, Franzosa EA, Morgan XC, Gevers D, Lander ES, Xavier RJ, Birren BW, Ko G, Huttenhower C. Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes. Genome Med. 2016 Feb 17; 8(1):17. PMID: 26884067; PMCID: PMC4756455.
  38. Lander ES. The Heroes of CRISPR. Cell. 2016 Jan 14; 164(1-2):18-28. PMID: 26771483.
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  39. Lowe CJ, Terasaki M, Wu M, Freeman RM, Runft L, Kwan K, Haigo S, Aronowicz J, Lander E, Gruber C, Smith M, Kirschner M, Gerhart J. Correction: Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution. PLoS Biol. 2015 Dec; 13(12):e1002354. PMID: 26714185; PMCID: PMC4700970.
  40. Kasar S, Kim J, Improgo R, Tiao G, Polak P, Haradhvala N, Lawrence MS, Kiezun A, Fernandes SM, Bahl S, Sougnez C, Gabriel S, Lander ES, Kim HT, Getz G, Brown JR. Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution. Nat Commun. 2015 Dec 07; 6:8866. PMID: 26638776; PMCID: PMC4686820.
  41. Sanborn AL, Rao SS, Huang SC, Durand NC, Huntley MH, Jewett AI, Bochkov ID, Chinnappan D, Cutkosky A, Li J, Geeting KP, Gnirke A, Melnikov A, McKenna D, Stamenova EK, Lander ES, Aiden EL. Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6456-65. PMID: 26499245; PMCID: PMC4664323.
  42. Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM. Identification and characterization of essential genes in the human genome. Science. 2015 Nov 27; 350(6264):1096-101. PMID: 26472758; PMCID: PMC4662922.
  43. Landau DA, Tausch E, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J, Kluth S, Bozic I, Lawrence M, Böttcher S, Carter SL, Cibulskis K, Mertens D, Sougnez CL, Rosenberg M, Hess JM, Edelmann J, Kless S, Kneba M, Ritgen M, Fink A, Fischer K, Gabriel S, Lander ES, Nowak MA, Döhner H, Hallek M, Neuberg D, Getz G, Stilgenbauer S, Wu CJ. Mutations driving CLL and their evolution in progression and relapse. Nature. 2015 Oct 22; 526(7574):525-30. PMID: 26466571; PMCID: PMC4815041.
  44. Golan D, Rosset S, Lander ES. Reply to Lee: Downward bias in heritability estimation is not due to simplified linkage equilibrium SNP simulation. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):E5452-3. PMID: 26417112; PMCID: PMC4603505.
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  270. Giallourakis C, Stoll M, Miller K, Hampe J, Lander ES, Daly MJ, Schreiber S, Rioux JD. IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis. Am J Hum Genet. 2003 Jul; 73(1):205-11. PMID: 12776251; PMCID: PMC1180582.
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  283. Williams CN, Kocher K, Lander ES, Daly MJ, Rioux JD. Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci. Inflamm Bowel Dis. 2002 Nov; 8(6):375-81. PMID: 12454612.
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  285. Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES. Detecting recent positive selection in the human genome from haplotype structure. Nature. 2002 Oct 24; 419(6909):832-7. PMID: 12397357.
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  286. Humpherys D, Eggan K, Akutsu H, Friedman A, Hochedlinger K, Yanagimachi R, Lander ES, Golub TR, Jaenisch R. Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12889-94. PMID: 12235366; PMCID: PMC130555.
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  294. Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, Biegel JA, Poggio T, Mukherjee S, Rifkin R, Califano A, Stolovitzky G, Louis DN, Mesirov JP, Lander ES, Golub TR. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature. 2002 Jan 24; 415(6870):436-42. PMID: 11807556.
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  305. Daly MJ, Rioux JD, Schaffner SF, Hudson TJ, Lander ES. High-resolution haplotype structure in the human genome. Nat Genet. 2001 Oct; 29(2):229-32. PMID: 11586305.
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  306. Hudson TJ, Church DM, Greenaway S, Nguyen H, Cook A, Steen RG, Van Etten WJ, Castle AB, Strivens MA, Trickett P, Heuston C, Davison C, Southwell A, Hardisty R, Varela-Carver A, Haynes AR, Rodriguez-Tome P, Doi H, Ko MS, Pontius J, Schriml L, Wagner L, Maglott D, Brown SD, Lander ES, Schuler G, Denny P. A radiation hybrid map of mouse genes. Nat Genet. 2001 Oct; 29(2):201-5. PMID: 11586302.
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  307. Rioux JD, Daly MJ, Silverberg MS, Lindblad K, Steinhart H, Cohen Z, Delmonte T, Kocher K, Miller K, Guschwan S, Kulbokas EJ, O'Leary S, Winchester E, Dewar K, Green T, Stone V, Chow C, Cohen A, Langelier D, Lapointe G, Gaudet D, Faith J, Branco N, Bull SB, McLeod RS, Griffiths AM, Bitton A, Greenberg GR, Lander ES, Siminovitch KA, Hudson TJ. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet. 2001 Oct; 29(2):223-8. PMID: 11586304.
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  308. Staunton JE, Slonim DK, Coller HA, Tamayo P, Angelo MJ, Park J, Scherf U, Lee JK, Reinhold WO, Weinstein JN, Mesirov JP, Lander ES, Golub TR. Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10787-92. PMID: 11553813; PMCID: PMC58553.
  309. Reich DE, Lander ES. On the allelic spectrum of human disease. Trends Genet. 2001 Sep; 17(9):502-10. PMID: 11525833.
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  310. Barclay J, Balaguero N, Mione M, Ackerman SL, Letts VA, Brodbeck J, Canti C, Meir A, Page KM, Kusumi K, Perez-Reyes E, Lander ES, Frankel WN, Gardiner RM, Dolphin AC, Rees M. Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. J Neurosci. 2001 Aug 15; 21(16):6095-104. PMID: 11487633.
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  311. Ardlie K, Liu-Cordero SN, Eberle MA, Daly M, Barrett J, Winchester E, Lander ES, Kruglyak L. Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. Am J Hum Genet. 2001 Sep; 69(3):582-9. PMID: 11473344; PMCID: PMC1235487.
  312. Hirschhorn JN, Lindgren CM, Daly MJ, Kirby A, Schaffner SF, Burtt NP, Altshuler D, Parker A, Rioux JD, Platko J, Gaudet D, Hudson TJ, Groop LC, Lander ES. Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet. 2001 Jul; 69(1):106-16. PMID: 11410839; PMCID: PMC1226025.
  313. Inoue K, Dewar K, Katsanis N, Reiter LT, Lander ES, Devon KL, Wyman DW, Lupski JR, Birren B. The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. Genome Res. 2001 Jun; 11(6):1018-33. PMID: 11381029; PMCID: PMC311111.
  314. Sklar P, Schwab SG, Williams NM, Daly M, Schaffner S, Maier W, Albus M, Trixler M, Eichhammer P, Lerer B, Hallmayer J, Norton N, Williams H, Zammit S, Cardno AG, Jones S, McCarthy G, Milanova V, Kirov G, O'Donovan MC, Lander ES, Owen MJ, Wildenauer DB. Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nat Genet. 2001 Jun; 28(2):126-8. PMID: 11381257.
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  315. Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ, Lavery T, Kouyoumjian R, Farhadian SF, Ward R, Lander ES. Linkage disequilibrium in the human genome. Nature. 2001 May 10; 411(6834):199-204. PMID: 11346797.
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  316. Laitinen T, Daly MJ, Rioux JD, Kauppi P, Laprise C, Petäys T, Green T, Cargill M, Haahtela T, Lander ES, Laitinen LA, Hudson TJ, Kere J. A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Nat Genet. 2001 May; 28(1):87-91. PMID: 11326283.
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  317. Sweeney C, Fambrough D, Huard C, Diamonti AJ, Lander ES, Cantley LC, Carraway KL. Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors. J Biol Chem. 2001 Jun 22; 276(25):22685-98. PMID: 11297548.
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  318. Hong KH, Bonventre JC, O'Leary E, Bonventre JV, Lander ES. Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3935-9. PMID: 11274413; PMCID: PMC31157.
  319. Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature. 2001 Feb 15; 409(6822):928-33. PMID: 11237013.
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  320. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann Y, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blöcker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowki J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ, Szustakowki J. Initial sequencing and analysis of the human genome. Nature. 2001 Feb 15; 409(6822):860-921. PMID: 11237011.
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  321. Bartoloni L, Blouin JL, Maiti AK, Sainsbury A, Rossier C, Gehrig C, She JX, Marron MP, Lander ES, Meeks M, Chung E, Armengot M, Jorissen M, Scott HS, Delozier-Blanchet CD, Gardiner RM, Antonarakis SE. Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia. Genomics. 2001 Feb 15; 72(1):21-33. PMID: 11247663.
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  322. Causton HC, Ren B, Koh SS, Harbison CT, Kanin E, Jennings EG, Lee TI, True HL, Lander ES, Young RA. Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell. 2001 Feb; 12(2):323-37. PMID: 11179418; PMCID: PMC30946.
  323. Lee N, Daly MJ, Delmonte T, Lander ES, Xu F, Hudson TJ, Mitchell GA, Morin CC, Robinson BH, Rioux JD. A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac-Saint-Jean cytochrome oxidase deficiency to 2p16. Am J Hum Genet. 2001 Feb; 68(2):397-409. PMID: 11156535; PMCID: PMC1235273.
  324. Jackson-Grusby L, Beard C, Possemato R, Tudor M, Fambrough D, Csankovszki G, Dausman J, Lee P, Wilson C, Lander E, Jaenisch R. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet. 2001 Jan; 27(1):31-9. PMID: 11137995.
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  325. Yeang CH, Ramaswamy S, Tamayo P, Mukherjee S, Rifkin RM, Angelo M, Reich M, Lander E, Mesirov J, Golub T. Molecular classification of multiple tumor types. Bioinformatics. 2001; 17 Suppl 1:S316-22. PMID: 11473023.
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  326. Pajukanta P, Cargill M, Viitanen L, Nuotio I, Kareinen A, Perola M, Terwilliger JD, Kempas E, Daly M, Lilja H, Rioux JD, Brettin T, Viikari JS, Rönnemaa T, Laakso M, Lander ES, Peltonen L. Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. Am J Hum Genet. 2000 Dec; 67(6):1481-93. PMID: 11078477; PMCID: PMC1287925.
  327. Hirschhorn JN, Sklar P, Lindblad-Toh K, Lim YM, Ruiz-Gutierrez M, Bolk S, Langhorst B, Schaffner S, Winchester E, Lander ES. SBE-TAGS: an array-based method for efficient single-nucleotide polymorphism genotyping. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12164-9. PMID: 11035790; PMCID: PMC17312.
  328. Altshuler D, Pollara VJ, Cowles CR, Van Etten WJ, Baldwin J, Linton L, Lander ES. An SNP map of the human genome generated by reduced representation shotgun sequencing. Nature. 2000 Sep 28; 407(6803):513-6. PMID: 11029002.
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  329. Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, Lander ES. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet. 2000 Sep; 26(1):76-80. PMID: 10973253.
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  330. Lindblad-Toh K, Tanenbaum DM, Daly MJ, Winchester E, Lui WO, Villapakkam A, Stanton SE, Larsson C, Hudson TJ, Johnson BE, Lander ES, Meyerson M. Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nat Biotechnol. 2000 Sep; 18(9):1001-5. PMID: 10973224.
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  331. Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature. 2000 Aug 03; 406(6795):532-5. PMID: 10952316.
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  332. Batzoglou S, Pachter L, Mesirov JP, Berger B, Lander ES. Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Res. 2000 Jul; 10(7):950-8. PMID: 10899144; PMCID: PMC310911.
  333. Cormier RT, Bilger A, Lillich AJ, Halberg RB, Hong KH, Gould KA, Borenstein N, Lander ES, Dove WF. The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64. Oncogene. 2000 Jun 29; 19(28):3182-92. PMID: 10918573.
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  334. Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, McLeod RS, Griffiths AM, Green T, Brettin TS, Stone V, Bull SB, Bitton A, Williams CN, Greenberg GR, Cohen Z, Lander ES, Hudson TJ, Siminovitch KA. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet. 2000 Jun; 66(6):1863-70. PMID: 10777714; PMCID: PMC1378042.
  335. Lindblad-Toh K, Winchester E, Daly MJ, Wang DG, Hirschhorn JN, Laviolette JP, Ardlie K, Reich DE, Robinson E, Sklar P, Shah N, Thomas D, Fan JB, Gingeras T, Warrington J, Patil N, Hudson TJ, Lander ES. Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat Genet. 2000 Apr; 24(4):381-6. PMID: 10742102.
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  336. Bulman MP, Kusumi K, Frayling TM, McKeown C, Garrett C, Lander ES, Krumlauf R, Hattersley AT, Ellard S, Turnpenny PD. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nat Genet. 2000 Apr; 24(4):438-41. PMID: 10742114.
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  337. Coller HA, Grandori C, Tamayo P, Colbert T, Lander ES, Eisenman RN, Golub TR. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3260-5. PMID: 10737792; PMCID: PMC16226.
  338. Lander ES, Weinberg RA. Genomics: journey to the center of biology. Science. 2000 Mar 10; 287(5459):1777-82. PMID: 10755930.
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  339. Nadeau JH, Singer JB, Matin A, Lander ES. Analysing complex genetic traits with chromosome substitution strains. Nat Genet. 2000 Mar; 24(3):221-5. PMID: 10700173.
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  340. Engert JC, Bérubé P, Mercier J, Doré C, Lepage P, Ge B, Bouchard JP, Mathieu J, Melançon SB, Schalling M, Lander ES, Morgan K, Hudson TJ, Richter A. ARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORF. Nat Genet. 2000 Feb; 24(2):120-5. PMID: 10655055.
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  341. Lander ES. Genomics: launching a revolution in medicine. J Law Med Ethics. 2000; 28(4 Suppl):3-14. PMID: 11244841.
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  342. De Sanctis GT, Singer JB, Jiao A, Yandava CN, Lee YH, Haynes TC, Lander ES, Beier DR, Drazen JM. Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. Am J Physiol. 1999 Dec; 277(6 Pt 1):L1118-23. PMID: 10600881.
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  343. Batzoglou S, Berger B, Mesirov J, Lander ES. Sequencing a genome by walking with clone-end sequences: a mathematical analysis. Genome Res. 1999 Dec; 9(12):1163-74. PMID: 10613838.
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  344. Wyrick JJ, Holstege FC, Jennings EG, Causton HC, Shore D, Grunstein M, Lander ES, Young RA. Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast. Nature. 1999 Nov 25; 402(6760):418-21. PMID: 10586882.
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  345. Madhani HD, Galitski T, Lander ES, Fink GR. Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12530-5. PMID: 10535956; PMCID: PMC22972.
  346. Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999 Oct 15; 286(5439):531-7. PMID: 10521349.
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  347. Pachter L, Batzoglou S, Spitkovsky VI, Banks E, Lander ES, Kleitman DJ, Berger B. A dictionary-based approach for gene annotation. J Comput Biol. 1999 Fall-Winter; 6(3-4):419-30. PMID: 10582576.
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  348. Klaff LS, Koike G, Jiang J, Wang Y, Bieg S, Pettersson A, Lander E, Jacob H, Lernmark A. BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Mamm Genome. 1999 Sep; 10(9):883-7. PMID: 10441739.
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  349. Sidow A, Bulotsky MS, Kerrebrock AW, Birren BW, Altshuler D, Jaenisch R, Johnson KR, Lander ES. A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant. Nat Genet. 1999 Sep; 23(1):104-7. PMID: 10471509.
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  350. Hästbacka J, Kerrebrock A, Mokkala K, Clines G, Lovett M, Kaitila I, de la Chapelle A, Lander ES. Identification of the Finnish founder mutation for diastrophic dysplasia (DTD). Eur J Hum Genet. 1999 Sep; 7(6):664-70. PMID: 10482955.
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  351. Van Etten WJ, Steen RG, Nguyen H, Castle AB, Slonim DK, Ge B, Nusbaum C, Schuler GD, Lander ES, Hudson TJ. Radiation hybrid map of the mouse genome. Nat Genet. 1999 Aug; 22(4):384-7. PMID: 10431245.
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  352. Nusbaum C, Slonim DK, Harris KL, Birren BW, Steen RG, Stein LD, Miller J, Dietrich WF, Nahf R, Wang V, Merport O, Castle AB, Husain Z, Farino G, Gray D, Anderson MO, Devine R, Horton LT, Ye W, Wu X, Kouyoumjian V, Zemsteva IS, Wu Y, Collymore AJ, Courtney DF, Tam J, Cadman M, Haynes AR, Heuston C, Marsland T, Southwell A, Trickett P, Strivens MA, Ross MT, Makalowski W, Xu Y, Boguski MS, Carter NP, Denny P, Brown SD, Hudson TJ, Lander ES. A YAC-based physical map of the mouse genome. Nat Genet. 1999 Aug; 22(4):388-93. PMID: 10431246.
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  353. Galitski T, Saldanha AJ, Styles CA, Lander ES, Fink GR. Ploidy regulation of gene expression. Science. 1999 Jul 09; 285(5425):251-4. PMID: 10398601.
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  354. Klockars T, Holmberg V, Savukoski M, Lander ES, Peltonen L. Transcript identification on the CLN5 region on chromosome 13q22. Hum Genet. 1999 Jul-Aug; 105(1-2):51-6. PMID: 10480355.
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  355. Pfeifer D, Kist R, Dewar K, Devon K, Lander ES, Birren B, Korniszewski L, Back E, Scherer G. Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: evidence for an extended control region. Am J Hum Genet. 1999 Jul; 65(1):111-24. PMID: 10364523; PMCID: PMC1378081.
  356. Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet. 1999 Jul; 22(3):231-8. PMID: 10391209.
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  357. Fambrough D, McClure K, Kazlauskas A, Lander ES. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell. 1999 Jun 11; 97(6):727-41. PMID: 10380925.
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  358. Hacia JG, Fan JB, Ryder O, Jin L, Edgemon K, Ghandour G, Mayer RA, Sun B, Hsie L, Robbins CM, Brody LC, Wang D, Lander ES, Lipshutz R, Fodor SP, Collins FS. Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet. 1999 Jun; 22(2):164-7. PMID: 10369258.
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  359. Szpirer C, Szpirer J, Van Vooren P, Tissir F, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G. Gene-based anchoring of the rat genetic linkage and cytogenetic maps. Transplant Proc. 1999 May; 31(3):1541-3. PMID: 10330994.
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  360. Tamayo P, Slonim D, Mesirov J, Zhu Q, Kitareewan S, Dmitrovsky E, Lander ES, Golub TR. Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2907-12. PMID: 10077610; PMCID: PMC15868.
  361. Lander ES. Array of hope. Nat Genet. 1999 Jan; 21(1 Suppl):3-4. PMID: 9915492.
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  362. Ross RK, Coetzee GA, Pearce CL, Reichardt JK, Bretsky P, Kolonel LN, Henderson BE, Lander E, Altshuler D, Daley G. Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility. Eur Urol. 1999; 35(5-6):355-61. PMID: 10325489.
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  363. Pardes H, Manton KG, Lander ES, Tolley HD, Ullian AD, Palmer H. Effects of medical research on health care and economy. Science. 1999 Jan 01; 283(5398):36-7. PMID: 9917262.
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  364. Holstege FC, Jennings EG, Wyrick JJ, Lee TI, Hengartner CJ, Green MR, Golub TR, Lander ES, Young RA. Dissecting the regulatory circuitry of a eukaryotic genome. Cell. 1998 Nov 25; 95(5):717-28. PMID: 9845373.
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  365. Lander ES, Ellis JJ. Founding father. Nature. 1998 Nov 05; 396(6706):13-4. PMID: 9817195.
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  366. Rioux JD, Daly MJ, Green T, Stone V, Lander ES, Hudson TJ, Steinhart AH, Bull S, Cohen Z, Greenberg G, Griffiths A, McLeod R, Silverberg M, Williams CN, Siminovitch KA. Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12, and 16. Gastroenterology. 1998 Nov; 115(5):1062-5. PMID: 9797358.
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  368. Rioux JD, Stone VA, Daly MJ, Cargill M, Green T, Nguyen H, Nutman T, Zimmerman PA, Tucker MA, Hudson T, Goldstein AM, Lander E, Lin AY. Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33. Am J Hum Genet. 1998 Oct; 63(4):1086-94. PMID: 9758611; PMCID: PMC1377485.
  369. Szpirer C, Szpirer J, Van Vooren P, Tissir F, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Mamm Genome. 1998 Sep; 9(9):721-34. PMID: 9716657.
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  370. Ober C, Cox NJ, Abney M, Di Rienzo A, Lander ES, Changyaleket B, Gidley H, Kurtz B, Lee J, Nance M, Pettersson A, Prescott J, Richardson A, Schlenker E, Summerhill E, Willadsen S, Parry R. Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Hum Mol Genet. 1998 Sep; 7(9):1393-8. PMID: 9700192.
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  371. Brown DM, Matise TC, Koike G, Simon JS, Winer ES, Zangen S, McLaughlin MG, Shiozawa M, Atkinson OS, Hudson JR, Chakravarti A, Lander ES, Jacob HJ. An integrated genetic linkage map of the laboratory rat. Mamm Genome. 1998 Jul; 9(7):521-30. PMID: 9657848.
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  372. Savukoski M, Klockars T, Holmberg V, Santavuori P, Lander ES, Peltonen L. CLN5, a novel gene encoding a putative transmembrane protein mutated in Finnish variant late infantile neuronal ceroid lipofuscinosis. Nat Genet. 1998 Jul; 19(3):286-8. PMID: 9662406.
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  373. Kusumi K, Sun ES, Kerrebrock AW, Bronson RT, Chi DC, Bulotsky MS, Spencer JB, Birren BW, Frankel WN, Lander ES. The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet. 1998 Jul; 19(3):274-8. PMID: 9662403.
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  374. Altshuler D, Kruglyak L, Lander E. Genetic polymorphisms and disease. N Engl J Med. 1998 May 28; 338(22):1626. PMID: 9606122.
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  375. Wang DG, Fan JB, Siao CJ, Berno A, Young P, Sapolsky R, Ghandour G, Perkins N, Winchester E, Spencer J, Kruglyak L, Stein L, Hsie L, Topaloglou T, Hubbell E, Robinson E, Mittmann M, Morris MS, Shen N, Kilburn D, Rioux J, Nusbaum C, Rozen S, Hudson TJ, Lipshutz R, Chee M, Lander ES. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science. 1998 May 15; 280(5366):1077-82. PMID: 9582121.
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  376. Bieg S, Koike G, Jiang J, Klaff L, Pettersson A, MacMurray AJ, Jacob HJ, Lander ES, Lernmark A. Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Mamm Genome. 1998 Apr; 9(4):324-6. PMID: 9530633.
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  377. Zhong TP, Kaphingst K, Akella U, Haldi M, Lander ES, Fishman MC. Zebrafish genomic library in yeast artificial chromosomes. Genomics. 1998 Feb 15; 48(1):136-8. PMID: 9503028.
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  378. Kruglyak L, Lander ES. Faster multipoint linkage analysis using Fourier transforms. J Comput Biol. 1998; 5(1):1-7. PMID: 9541867.
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  379. Lander ES. Scientific commentary: the scientific foundations and medical and social prospects of the Human Genome Project. J Law Med Ethics. 1998; 26(3):184-8, 178. PMID: 11066875.
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  380. McCarthy MI, Kruglyak L, Lander ES. Sib-pair collection strategies for complex diseases. Genet Epidemiol. 1998; 15(4):317-40. PMID: 9671984.
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  381. Kuokkanen S, Gschwend M, Rioux JD, Daly MJ, Terwilliger JD, Tienari PJ, Wikström J, Palo J, Stein LD, Hudson TJ, Lander ES, Peltonen L. Genomewide scan of multiple sclerosis in Finnish multiplex families. Am J Hum Genet. 1997 Dec; 61(6):1379-87. PMID: 9399895; PMCID: PMC1716063.
  382. Laitinen T, Kauppi P, Ignatius J, Ruotsalainen T, Daly MJ, Kääriäinen H, Kruglyak L, Laitinen H, de la Chapelle A, Lander ES, Laitinen LA, Kere J. Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Hum Mol Genet. 1997 Nov; 6(12):2069-76. PMID: 9328470.
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  383. Sidow A, Bulotsky MS, Kerrebrock AW, Bronson RT, Daly MJ, Reeve MP, Hawkins TL, Birren BW, Jaenisch R, Lander ES. Serrate2 is disrupted in the mouse limb-development mutant syndactylism. Nature. 1997 Oct 16; 389(6652):722-5. PMID: 9338782.
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  384. Shi YP, Mohapatra G, Miller J, Hanahan D, Lander E, Gold P, Pinkel D, Gray J. FISH probes for mouse chromosome identification. Genomics. 1997 Oct 01; 45(1):42-7. PMID: 9339359.
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  385. Kong A, Frigge M, Bell GI, Lander ES, Daly MJ, Cox NJ. Diabetes, dependence, asymptotics, selection and significance. Nat Genet. 1997 Oct; 17(2):148. PMID: 9326932.
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  386. Fazeli A, Steen RG, Dickinson SL, Bautista D, Dietrich WF, Bronson RT, Bresalier RS, Lander ES, Costa J, Weinberg RA. Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10199-204. PMID: 9294187; PMCID: PMC23339.
  387. Cormier RT, Hong KH, Halberg RB, Hawkins TL, Richardson P, Mulherkar R, Dove WF, Lander ES. Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet. 1997 Sep; 17(1):88-91. PMID: 9288104.
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  388. Radany EH, Hong K, Kesharvarzi S, Lander ES, Bishop JM. Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8664-9. PMID: 9238034; PMCID: PMC23068.
  389. Hawkins TL, McKernan KJ, Jacotot LB, MacKenzie JB, Richardson PM, Lander ES. A magnetic attraction to high-throughput genomics. Science. 1997 Jun 20; 276(5320):1887-9. PMID: 9206843.
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  390. Hamilton BA, Smith DJ, Mueller KL, Kerrebrock AW, Bronson RT, van Berkel V, Daly MJ, Kruglyak L, Reeve MP, Nemhauser JL, Hawkins TL, Rubin EM, Lander ES. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May; 18(5):711-22. PMID: 9182797.
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  391. Haldi ML, Lim P, Kaphingst K, Akella U, Whang J, Lander ES. Construction of a large-insert yeast artificial chromosome library of the rat genome. Mamm Genome. 1997 Apr; 8(4):284. PMID: 9096113.
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  392. Lehto M, Tuomi T, Mahtani MM, Widén E, Forsblom C, Sarelin L, Gullström M, Isomaa B, Lehtovirta M, Hyrkkö A, Kanninen T, Orho M, Manley S, Turner RC, Brettin T, Kirby A, Thomas J, Duyk G, Lander E, Taskinen MR, Groop L. Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect. J Clin Invest. 1997 Feb 15; 99(4):582-91. PMID: 9045858; PMCID: PMC507838.
  393. Lander ES. Genes and genomes. Harvey Lect. 1997-1998; 93:35-48. PMID: 10941417.
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  394. Slonim D, Kruglyak L, Stein L, Lander E. Building human genome maps with radiation hybrids. J Comput Biol. 1997; 4(4):487-504. PMID: 9385541.
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  395. Gould KA, Dietrich WF, Borenstein N, Lander ES, Dove WF. Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics. 1996 Dec; 144(4):1769-76. PMID: 8978062; PMCID: PMC1207726.
  396. Gould KA, Luongo C, Moser AR, McNeley MK, Borenstein N, Shedlovsky A, Dove WF, Hong K, Dietrich WF, Lander ES. Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics. 1996 Dec; 144(4):1777-85. PMID: 8978063; PMCID: PMC1207727.
  397. Lander ES. The new genomics: global views of biology. Science. 1996 Oct 25; 274(5287):536-9. PMID: 8928008.
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  398. Schuler GD, Boguski MS, Hudson TJ, Hui L, Ma J, Castle AB, Wu X, Silva J, Nusbaum HC, Birren BB, Slonim DK, Rozen S, Stein LD, Page D, Lander ES, Stewart EA, Aggarwal A, Bajorek E, Brady S, Chu S, Fang N, Hadley D, Harris M, Hussain S, Hudson JR, et al. Genome maps 7. The human transcript map. Wall chart. Science. 1996 Oct 25; 274(5287):547-62. PMID: 8928009.
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  399. Schuler GD, Boguski MS, Stewart EA, Stein LD, Gyapay G, Rice K, White RE, Rodriguez-Tomé P, Aggarwal A, Bajorek E, Bentolila S, Birren BB, Butler A, Castle AB, Chiannilkulchai N, Chu A, Clee C, Cowles S, Day PJ, Dibling T, Drouot N, Dunham I, Duprat S, East C, Edwards C, Fan JB, Fang N, Fizames C, Garrett C, Green L, Hadley D, Harris M, Harrison P, Brady S, Hicks A, Holloway E, Hui L, Hussain S, Louis-Dit-Sully C, Ma J, MacGilvery A, Mader C, Maratukulam A, Matise TC, McKusick KB, Morissette J, Mungall A, Muselet D, Nusbaum HC, Page DC, Peck A, Perkins S, Piercy M, Qin F, Quackenbush J, Ranby S, Reif T, Rozen S, Sanders C, She X, Silva J, Slonim DK, Soderlund C, Sun WL, Tabar P, Thangarajah T, Vega-Czarny N, Vollrath D, Voyticky S, Wilmer T, Wu X, Adams MD, Auffray C, Walter NA, Brandon R, Dehejia A, Goodfellow PN, Houlgatte R, Hudson JR, Ide SE, Iorio KR, Lee WY, Seki N, Nagase T, Ishikawa K, Nomura N, Phillips C, Polymeropoulos MH, Sandusky M, Schmitt K, Berry R, Swanson K, Torres R, Venter JC, Sikela JM, Beckmann JS, Weissenbach J, Myers RM, Cox DR, James MR, Bentley D, Deloukas P, Lander ES, Hudson TJ. A gene map of the human genome. Science. 1996 Oct 25; 274(5287):540-6. PMID: 8849440.
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  400. Haldi ML, Strickland C, Lim P, VanBerkel V, Chen X, Noya D, Korenberg JR, Husain Z, Miller J, Lander ES. A comprehensive large-insert yeast artificial chromosome library for physical mapping of the mouse genome. Mamm Genome. 1996 Oct; 7(10):767-9. PMID: 8854865.
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  401. Daly MJ, Lander ES. The importance of being independent: sib pair analysis in diabetes. Nat Genet. 1996 Oct; 14(2):131-2. PMID: 8841179.
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  402. Mahtani MM, Widén E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forsblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, Reeve-Daly MP, Weaver A, Brettin T, Duyk G, Lander ES, Groop LC. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet. 1996 Sep; 14(1):90-4. PMID: 8782826.
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  403. Navin A, Prekeris R, Lisitsyn NA, Sonti MM, Grieco DA, Narayanswami S, Lander ES, Simpson EM. Mouse Y-specific repeats isolated by whole chromosome representational difference analysis. Genomics. 1996 Sep 01; 36(2):349-53. PMID: 8812464.
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  404. Gschwend M, Levran O, Kruglyak L, Ranade K, Verlander PC, Shen S, Faure S, Weissenbach J, Altay C, Lander ES, Auerbach AD, Botstein D. A locus for Fanconi anemia on 16q determined by homozygosity mapping. Am J Hum Genet. 1996 Aug; 59(2):377-84. PMID: 8755924; PMCID: PMC1914713.
  405. Superti-Furga A, Hästbacka J, Rossi A, van der Harten JJ, Wilcox WR, Cohn DH, Rimoin DL, Steinmann B, Lander ES, Gitzelmann R. A family of chondrodysplasias caused by mutations in the diastrophic dysplasia sulfate transporter gene and associated with impaired sulfation of proteoglycans. Ann N Y Acad Sci. 1996 Jun 08; 785:195-201. PMID: 8702127.
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  406. Hästbacka J, Superti-Furga A, Wilcox WR, Rimoin DL, Cohn DH, Lander ES. Sulfate transport in chondrodysplasia. Ann N Y Acad Sci. 1996 Jun 08; 785:131-6. PMID: 8702119.
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  407. Kurooka H, Segre JA, Hirano Y, Nemhauser JL, Nishimura H, Yoneda K, Lander ES, Honjo T. Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus. Int Immunol. 1996 Jun; 8(6):961-6. PMID: 8671685.
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  408. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet. 1996 Jun; 58(6):1347-63. PMID: 8651312; PMCID: PMC1915045.
  409. Kruglyak L, Lander ES. Limits on fine mapping of complex traits. Am J Hum Genet. 1996 May; 58(5):1092-3. PMID: 8651271; PMCID: PMC1914627.
  410. Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 1996 Feb 22; 379(6567):736-9. PMID: 8602221.
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  411. Hästbacka J, Superti-Furga A, Wilcox WR, Rimoin DL, Cohn DH, Lander ES. Atelosteogenesis type II is caused by mutations in the diastrophic dysplasia sulfate-transporter gene (DTDST): evidence for a phenotypic series involving three chondrodysplasias. Am J Hum Genet. 1996 Feb; 58(2):255-62. PMID: 8571951; PMCID: PMC1914552.
  412. Yi TM, Lander ES. Iterative template refinement: protein-fold prediction using iterative search and hybrid sequence/structure templates. Methods Enzymol. 1996; 266:322-39. PMID: 8743692.
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  413. Superti-Furga A, Hästbacka J, Wilcox WR, Cohn DH, van der Harten HJ, Rossi A, Blau N, Rimoin DL, Steinmann B, Lander ES, Gitzelmann R. Achondrogenesis type IB is caused by mutations in the diastrophic dysplasia sulphate transporter gene. Nat Genet. 1996 Jan; 12(1):100-2. PMID: 8528239.
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  414. Galli J, Li LS, Glaser A, Ostenson CG, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet. 1996 Jan; 12(1):31-7. PMID: 8528247.
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  415. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet. 1996 Jan; 12(1):44-51. PMID: 8528250.
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  416. Hudson TJ, Stein LD, Gerety SS, Ma J, Castle AB, Silva J, Slonim DK, Baptista R, Kruglyak L, Xu SH, Hu X, Colbert AM, Rosenberg C, Reeve-Daly MP, Rozen S, Hui L, Wu X, Vestergaard C, Wilson KM, Bae JS, Maitra S, Ganiatsas S, Evans CA, DeAngelis MM, Ingalls KA, Nahf RW, Horton LT, Anderson MO, Collymore AJ, Ye W, Kouyoumjian V, Zemsteva IS, Tam J, Devine R, Courtney DF, Renaud MT, Nguyen H, O'Connor TJ, Fizames C, Fauré S, Gyapay G, Dib C, Morissette J, Orlin JB, Birren BW, Goodman N, Weissenbach J, Hawkins TL, Foote S, Page DC, Lander ES. An STS-based map of the human genome. Science. 1995 Dec 22; 270(5244):1945-54. PMID: 8533086.
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  417. Parangi S, Dietrich W, Christofori G, Lander ES, Hanahan D. Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma. Cancer Res. 1995 Dec 15; 55(24):6071-6. PMID: 8521395.
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  418. Dietrich WF, Copeland NG, Gilbert DJ, Miller JC, Jenkins NA, Lander ES. Mapping the mouse genome: current status and future prospects. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):10849-53. PMID: 7479896; PMCID: PMC40528.
  419. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995 Nov; 11(3):241-7. PMID: 7581446.
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  420. De Sanctis GT, Merchant M, Beier DR, Dredge RD, Grobholz JK, Martin TR, Lander ES, Drazen JM. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet. 1995 Oct; 11(2):150-4. PMID: 7550342.
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  421. Schork NJ, Krieger JE, Trolliet MR, Franchini KG, Koike G, Krieger EM, Lander ES, Dzau VJ, Jacob HJ. A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. Genome Res. 1995 Sep; 5(2):164-72. PMID: 9132270.
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  422. Segre JA, Nemhauser JL, Taylor BA, Nadeau JH, Lander ES. Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat. Genomics. 1995 Aug 10; 28(3):549-59. PMID: 7490093.
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  423. Kruglyak L, Lander ES. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet. 1995 Aug; 57(2):439-54. PMID: 7668271; PMCID: PMC1801561.
  424. Pettersson A, Wilson D, Daniels T, Tobin S, Jacob HJ, Lander ES, Lernmark A. Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes. J Autoimmun. 1995 Aug; 8(4):493-505. PMID: 7492346.
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  425. Kruglyak L, Lander ES. High-resolution genetic mapping of complex traits. Am J Hum Genet. 1995 May; 56(5):1212-23. PMID: 7726179; PMCID: PMC1801437.
  426. Dietrich WF, Damron DM, Isberg RR, Lander ES, Swanson MS. Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13. Genomics. 1995 Apr 10; 26(3):443-50. PMID: 7607666.
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  427. Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci. Genetics. 1995 Mar; 139(3):1421-8. PMID: 7768449; PMCID: PMC1206467.
  428. Kruglyak L, Daly MJ, Lander ES. Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am J Hum Genet. 1995 Feb; 56(2):519-27. PMID: 7847388; PMCID: PMC1801139.
  429. Goodman N, Lander ES, Oberai-Soltz R. Software availability. Science. 1995 Jan 06; 267(5194):17. PMID: 7809601.
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  430. Truett GE, Jacob HJ, Miller J, Drouin G, Bahary N, Smoller JW, Lander ES, Leibel RL. Genetic map of rat chromosome 5 including the fatty (fa) locus. Mamm Genome. 1995 Jan; 6(1):25-30. PMID: 7719022.
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  431. Haldi M, Perrot V, Saumier M, Desai T, Cohen D, Cherif D, Ward D, Lander ES. Large human YACs constructed in a rad52 strain show a reduced rate of chimerism. Genomics. 1994 Dec; 24(3):478-84. PMID: 7713499.
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  432. Hegi ME, Devereux TR, Dietrich WF, Cochran CJ, Lander ES, Foley JF, Maronpot RR, Anderson MW, Wiseman RW. Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation. Cancer Res. 1994 Dec 01; 54(23):6257-64. PMID: 7954475.
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  433. Lander ES, Budowle B. DNA fingerprinting dispute laid to rest. Nature. 1994 Oct 27; 371(6500):735-8. PMID: 7818670.
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  434. Lander ES, Schork NJ. Genetic dissection of complex traits. Science. 1994 Sep 30; 265(5181):2037-48. PMID: 8091226.
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  435. Cox DR, Green ED, Lander ES, Cohen D, Myers RM. Assessing mapping progress in the Human Genome Project. Science. 1994 Sep 30; 265(5181):2031-2. PMID: 8091223.
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  436. Dietrich WF, Radany EH, Smith JS, Bishop JM, Hanahan D, Lander ES. Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9451-5. PMID: 7937788; PMCID: PMC44830.
  437. Yi TM, Lander ES. Recognition of related proteins by iterative template refinement (ITR). Protein Sci. 1994 Aug; 3(8):1315-28. PMID: 7987226; PMCID: PMC2142931.
  438. Hsu LC, Kennan WS, Shepel LA, Jacob HJ, Szpirer C, Szpirer J, Lander ES, Gould MN. Genetic identification of Mcs-1, a rat mammary carcinoma suppressor gene. Cancer Res. 1994 May 15; 54(10):2765-70. PMID: 8168109.
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  439. Wiseman RW, Cochran C, Dietrich W, Lander ES, Söderkvist P. Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3759-63. PMID: 8170984; PMCID: PMC43661.
  440. Lisitsyn NA, Segre JA, Kusumi K, Lisitsyn NM, Nadeau JH, Frankel WN, Wigler MH, Lander ES. Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis. Nat Genet. 1994 Jan; 6(1):57-63. PMID: 8136836.
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  441. Dietrich WF, Lander ES, Smith JS, Moser AR, Gould KA, Luongo C, Borenstein N, Dove W. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell. 1993 Nov 19; 75(4):631-9. PMID: 8242739.
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  442. Yi TM, Lander ES. Protein secondary structure prediction using nearest-neighbor methods. J Mol Biol. 1993 Aug 20; 232(4):1117-29. PMID: 8371270.
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  443. Lehesjoki AE, Koskiniemi M, Norio R, Tirrito S, Sistonen P, Lander E, de la Chapelle A. Localization of the EPM1 gene for progressive myoclonus epilepsy on chromosome 21: linkage disequilibrium allows high resolution mapping. Hum Mol Genet. 1993 Aug; 2(8):1229-34. PMID: 8104628.
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  444. Lander ES. DNA fingerprinting: the NRC report. Science. 1993 May 28; 260(5112):1221. PMID: 8493559.
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  445. Lander ES. Finding similarities and differences among genomes. Nat Genet. 1993 May; 4(1):5-6. PMID: 8513322.
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  446. Luongo C, Gould KA, Su LK, Kinzler KW, Vogelstein B, Dietrich W, Lander ES, Moser AR. Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse. Genomics. 1993 Jan; 15(1):3-8. PMID: 8094372.
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  447. Kusumi K, Smith JS, Segre JA, Koos DS, Lander ES. Construction of a large-insert yeast artificial chromosome library of the mouse genome. Mamm Genome. 1993; 4(7):391-2. PMID: 8358173.
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  448. Lincoln SE, Lander ES. Systematic detection of errors in genetic linkage data. Genomics. 1992 Nov; 14(3):604-10. PMID: 1427888.
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  449. Stuber CW, Lincoln SE, Wolff DW, Helentjaris T, Lander ES. Identification of genetic factors contributing to heterosis in a hybrid from two elite maize inbred lines using molecular markers. Genetics. 1992 Nov; 132(3):823-39. PMID: 1468633; PMCID: PMC1205218.
  450. Hästbacka J, de la Chapelle A, Kaitila I, Sistonen P, Weaver A, Lander E. Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland. Nat Genet. 1992 Nov; 2(3):204-11. PMID: 1345170.
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  451. Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark A, Lander ES. Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet. 1992 Sep; 2(1):56-60. PMID: 1303251.
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  452. Goff DJ, Galvin K, Katz H, Westerfield M, Lander ES, Tabin CJ. Identification of polymorphic simple sequence repeats in the genome of the zebrafish. Genomics. 1992 Sep; 14(1):200-2. PMID: 1427829.
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  453. Waterman MS, Eggert M, Lander E. Parametric sequence comparisons. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):6090-3. PMID: 1631095; PMCID: PMC49443.
  454. Groot PC, Moen CJ, Dietrich W, Stoye JP, Lander ES, Demant P. The recombinant congenic strains for analysis of multigenic traits: genetic composition. FASEB J. 1992 Jul; 6(10):2826-35. PMID: 1634045.
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  455. Dietrich W, Katz H, Lincoln SE, Shin HS, Friedman J, Dracopoli NC, Lander ES. A genetic map of the mouse suitable for typing intraspecific crosses. Genetics. 1992 Jun; 131(2):423-47. PMID: 1353738; PMCID: PMC1205016.
  456. Dzau VJ, Jacob HJ, Lindpainter K, Ganten D, Lander ES. Genetic mapping in hypertension. J Vasc Surg. 1992 May; 15(5):930. PMID: 1578573.
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  457. Arratia R, Lander ES, Tavaré S, Waterman MS. Genomic mapping by anchoring random clones: a mathematical analysis. Genomics. 1991 Dec; 11(4):806-27. PMID: 1783390.
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  458. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao YP, Ganten D, Dzau VJ, Lander ES. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell. 1991 Oct 04; 67(1):213-24. PMID: 1655275.
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  459. Green P, Lander ES. Forensic DNA tests and hardy-weinberg equilibrium. Science. 1991 Aug 30; 253(5023):1038-9. PMID: 17775346.
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  460. Lander ES. Research on DNA typing catching up with courtroom application. Am J Hum Genet. 1991 May; 48(5):819-23. PMID: 1760000; PMCID: PMC1683053.
  461. MacMurray AJ, Weaver A, Shin HS, Lander ES. An automated method for DNA preparation from thousands of YAC clones. Nucleic Acids Res. 1991 Jan 25; 19(2):385-90. PMID: 2014175; PMCID: PMC333606.
  462. Paterson AH, Damon S, Hewitt JD, Zamir D, Rabinowitch HD, Lincoln SE, Lander ES, Tanksley SD. Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. Genetics. 1991 Jan; 127(1):181-97. PMID: 1673106; PMCID: PMC1204303.
  463. Lander ES, Green P. Counting algorithms for linkage: correction to Morton and Collins. Ann Hum Genet. 1991 Jan; 55(Pt 1):33-8. PMID: 2042933.
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  464. Lander ES, Lodish H. Mitochondrial diseases: gene mapping and gene therapy. Cell. 1990 Jun 15; 61(6):925-6. PMID: 2190693.
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  465. Accili D, Frapier C, Mosthaf L, McKeon C, Elbein SC, Permutt MA, Ramos E, Lander E, Ullrich A, Taylor SI. A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes. EMBO J. 1989 Sep; 8(9):2509-17. PMID: 2573522; PMCID: PMC401244.
  466. Lander ES. DNA fingerprinting on trial. Nature. 1989 Jun 15; 339(6225):501-5. PMID: 2567496.
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  467. Pato CN, Lander ES, Schulz SC. Prospects for the genetic analysis of schizophrenia. Schizophr Bull. 1989; 15(3):365-72. PMID: 2683037.
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  468. Lander ES, Botstein D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 1989 Jan; 121(1):185-99. PMID: 2563713; PMCID: PMC1203601.
  469. Lander ES, Daly MJ. Multipoint linkage analysis of the cystic fibrosis region. Prog Clin Biol Res. 1989; 329:47-52. PMID: 2622961.
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  470. Hulbert SH, Ilott TW, Legg EJ, Lincoln SE, Lander ES, Michelmore RW. Genetic analysis of the fungus, Bremia lactucae, using restriction fragment length polymorphisms. Genetics. 1988 Dec; 120(4):947-58. PMID: 2906309; PMCID: PMC1203586.
  471. Lander ES. Splitting schizophrenia. Nature. 1988 Nov 10; 336(6195):105-6. PMID: 2903447.
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  472. Paterson AH, Lander ES, Hewitt JD, Peterson S, Lincoln SE, Tanksley SD. Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature. 1988 Oct 20; 335(6192):721-6. PMID: 2902517.
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  473. Lander ES, Lincoln SE. The appropriate threshold for declaring linkage when allowing sex-specific recombination rates. Am J Hum Genet. 1988 Oct; 43(4):396-400. PMID: 3177382; PMCID: PMC1715500.
  474. Dracopoli NC, Stanger BZ, Ito CY, Call KM, Lincoln SE, Lander ES, Housman DE. A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I. Am J Hum Genet. 1988 Oct; 43(4):462-70. PMID: 2902785; PMCID: PMC1715484.
  475. Chang C, Bowman JL, DeJohn AW, Lander ES, Meyerowitz EM. Restriction fragment length polymorphism linkage map for Arabidopsis thaliana. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6856-60. PMID: 2901107; PMCID: PMC282077.
  476. Lander ES, Waterman MS. Genomic mapping by fingerprinting random clones: a mathematical analysis. Genomics. 1988 Apr; 2(3):231-9. PMID: 3294162.
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  477. Barker D, Green P, Knowlton R, Schumm J, Lander E, Oliphant A, Willard H, Akots G, Brown V, Gravius T, et al. Genetic linkage map of human chromosome 7 with 63 DNA markers. Proc Natl Acad Sci U S A. 1987 Nov; 84(22):8006-10. PMID: 2891136; PMCID: PMC299465.
  478. Donis-Keller H, Green P, Helms C, Cartinhour S, Weiffenbach B, Stephens K, Keith TP, Bowden DW, Smith DR, Lander ES, et al. A genetic linkage map of the human genome. Cell. 1987 Oct 23; 51(2):319-37. PMID: 3664638.
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  479. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newberg LA, Newburg L. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics. 1987 Oct; 1(2):174-81. PMID: 3692487.
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  480. Lander ES, Botstein D. Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science. 1987 Jun 19; 236(4808):1567-70. PMID: 2884728.
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  481. Lander ES, Green P. Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A. 1987 Apr; 84(8):2363-7. PMID: 3470801; PMCID: PMC304651.
  482. Lander ES, Botstein D. Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms. Proc Natl Acad Sci U S A. 1986 Oct; 83(19):7353-7. PMID: 2876423; PMCID: PMC386715.
  483. Lander ES, Botstein D. Consanguinity and heterogeneity: cystic fibrosis need not be homogeneous in Italy. Am J Hum Genet. 1986 Aug; 39(2):282-3. PMID: 3752091; PMCID: PMC1683934.
  484. Lander ES, Botstein D. Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:49-62. PMID: 2884068.
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