Professor of Medicine
Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical
Center for Life Science, Rm 0408
3 Blackfan Circle
Boston MA 02115
|Fujian Medical University , Fuzhou, China||M.D.||07/1984||Medicine|
|Suzhou Medical College , Suhzou, China||M.Sci.||07/1987||Pharmacology|
|Duke University, Durham, NC||Ph.D.||12/1992||Cell Biology|
|Salk Instittute, La Jolla, CA||Postdoctoral training||08/1996||Mol Cell Biol|
Our laboratory has been the pioneer in elucidating the role of protein conformational regulation after proline-directed phosphorylation in cell signaling in health and disease. Notably, we discovered a unique phosphorylation-specific proline isomerase, Pin1 that helps protect against Alzheimer’s disease and whose aberrant activation helps promote the development of cancer. Based on these discoveries, our laboratory is working to develop an antibody therapy for the early diagnosis and treatment of Alzheimer’s and traumatic brain injury, and Pin1 chemical inhibitors to overcome drug resistance in cancer treatments.
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