Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileKun Ping Lu, PH.D., M.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
New Research Building Rm 1030K
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/667-4143
Fax617/667-0610
vCardDownload vCard (login for email)

Collapse Biography 
Collapse education and training
Fujian Medical University , Fuzhou, ChinaM.D.07/1984Medicine
Suzhou Medical College , Suhzou, ChinaM.Sci.07/1987Pharmacology
Duke University, Durham, NCPh.D.12/1992Cell Biology
Salk Instittute, La Jolla, CAPostdoctoral training08/1996Mol Cell Biol

Collapse Overview 
Collapse overview
Our laboratory has been the pioneer in elucidating the role of protein conformational regulation after proline-directed phosphorylation in cell signaling in health and disease. Notably, we discovered a unique phosphorylation-specific proline isomerase, Pin1 that helps protect against Alzheimer’s disease and whose aberrant activation helps promote the development of cancer. Based on these discoveries, our laboratory is working to develop an antibody therapy for the early diagnosis and treatment of Alzheimer’s and traumatic brain injury, and Pin1 chemical inhibitors to overcome drug resistance in cancer treatments.


Collapse Featured Content 
Collapse Websites

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Albayram O, Kondo A, Mannix R, Smith C, Tsai CY, Li C, Herbert MK, Qiu J, Monuteaux M, Driver J, Yan S, Gormley W, Puccio AM, Okonkwo DO, Lucke-Wold B, Bailes J, Meehan W, Zeidel M, Lu KP, Zhou XZ. Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae. Nat Commun. 2017 Oct 17; 8(1):1000. PMID: 29042562.
    View in: PubMed
  2. Frain L, Swanson D, Cho K, Gagnon D, Lu KP, Betensky RA, Driver J. Association of cancer and Alzheimer's disease risk in a national cohort of veterans. Alzheimers Dement. 2017 Jul 12. PMID: 28711346.
    View in: PubMed
  3. Kondo A, Albayram O, Zhou XZ, Lu KP. Pin1 Knockout Mice: A Model for the Study of Tau Pathology in Alzheimer's Disease. Methods Mol Biol. 2017; 1523:415-425. PMID: 27975268.
    View in: PubMed
  4. Deng D, Zhang Y, Zhang J, Wang Z, Zhu L, Fang J, Xia B, Wang Z, Lu K, Ma W, Wei Z. Fluorination-enabled optimal morphology leads to over 11% efficiency for inverted small-molecule organic solar cells. Nat Commun. 2016 Dec 19; 7:13740. PMID: 27991486.
    View in: PubMed
  5. Albayram O, Herbert MK, Kondo A, Tsai CY, Baxley S, Lian X, Hansen M, Zhou XZ, Lu KP. Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration. Cell Biosci. 2016; 6:59. PMID: 27980715.
    View in: PubMed
  6. Lu KP, Kondo A, Albayram O, Herbert MK, Liu H, Zhou XZ. Potential of the Antibody Against cis-Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury. JAMA Neurol. 2016 Nov 01; 73(11):1356-1362. PMID: 27654282.
    View in: PubMed
  7. Zhou XZ, Lu KP. The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target. Nat Rev Cancer. 2016 07; 16(7):463-78. PMID: 27256007.
    View in: PubMed
  8. Balastik M, Zhou XZ, Alberich-Jorda M, Weissova R, Žiak J, Pazyra-Murphy MF, Cosker KE, Machonova O, Kozmikova I, Chen CH, Pastorino L, Asara JM, Cole A, Sutherland C, Segal RA, Lu KP. Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons. Cell Rep. 2015 Oct 27; 13(4):812-828. PMID: 26489457; PMCID: PMC4662601.
  9. Kondo A, Shahpasand K, Mannix R, Qiu J, Moncaster J, Chen CH, Yao Y, Lin YM, Driver JA, Sun Y, Wei S, Luo ML, Albayram O, Huang P, Rotenberg A, Ryo A, Goldstein LE, Pascual-Leone A, McKee AC, Meehan W, Zhou XZ, Lu KP. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. 2015 Jul 23; 523(7561):431-436. PMID: 26176913; PMCID: PMC4718588.
  10. Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, Chen CH, Rego EM, Lo-Coco F, Cantley LC, Lee TH, Wu H, Zhang Y, Pandolfi PP, Zhou XZ, Lu KP. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat Med. 2015 May; 21(5):457-66. PMID: 25849135; PMCID: PMC4425616.
  11. Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Rep. 2015 Apr 07; 11(1):111-24. PMID: 25818297; PMCID: PMC4401741.
  12. Driver JA, Zhou XZ, Lu KP. Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease. Biochim Biophys Acta. 2015 Oct; 1850(10):2069-76. PMID: 25583562; PMCID: PMC4499009 [Available on 10/01/16].
  13. Chen CH, Li W, Sultana R, You MH, Kondo A, Shahpasand K, Kim BM, Luo ML, Nechama M, Lin YM, Yao Y, Lee TH, Zhou XZ, Swomley AM, Allan Butterfield D, Zhang Y, Lu KP. Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease. Neurobiol Dis. 2015 Apr; 76:13-23. PMID: 25576397; PMCID: PMC4423621.
  14. Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer Res. 2014 Jul 01; 74(13):3603-16. PMID: 24786790; PMCID: PMC4079726.
  15. Jalouli M, Déry MA, Lafleur VN, Lamalice L, Zhou XZ, Lu KP, Richard DE. The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity. Cell Signal. 2014 Aug; 26(8):1649-56. PMID: 24726894.
    View in: PubMed
  16. Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24; 508(7497):541-5. PMID: 24670654; PMCID: PMC4076493.
  17. Driver JA, Zhou XZ, Lu KP. Regulation of protein conformation by Pin1 offers novel disease mechanisms and therapeutic approaches in Alzheimer's disease. Discov Med. 2014 Feb; 17(92):93-9. PMID: 24534472; PMCID: PMC4076490.
  18. Nakamura K, Zhou XZ, Lu KP. Distinct functions of cis and trans phosphorylated tau in Alzheimer's disease and their therapeutic implications. Curr Mol Med. 2013 Aug; 13(7):1098-109. PMID: 23157676.
    View in: PubMed
  19. Knutson CG, Mangerich A, Zeng Y, Raczynski AR, Liberman RG, Kang P, Ye W, Prestwich EG, Lu K, Wishnok JS, Korzenik JR, Wogan GN, Fox JG, Dedon PC, Tannenbaum SR. Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2332-41. PMID: 23754421; PMCID: PMC3696795.
  20. Chen CH, Chang CC, Lee TH, Luo M, Huang P, Liao PH, Wei S, Li FA, Chen RH, Zhou XZ, Shih HM, Lu KP. SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function. Cancer Res. 2013 Jul 01; 73(13):3951-62. PMID: 23633483; PMCID: PMC3818121.
  21. Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Völkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Müller OJ, Uchida T, Sussman MA. Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Circ Res. 2013 Apr 26; 112(9):1244-52. PMID: 23487407; PMCID: PMC3742109.
  22. Keune WJ, Jones DR, Bultsma Y, Sommer L, Zhou XZ, Lu KP, Divecha N. Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress. Sci Signal. 2012 Nov 27; 5(252):ra86. PMID: 23193159.
    View in: PubMed
  23. De S, Greenwood AI, Rogals MJ, Kovrigin EL, Lu KP, Nicholson LK. Complete thermodynamic and kinetic characterization of the isomer-specific interaction between Pin1-WW domain and the amyloid precursor protein cytoplasmic tail phosphorylated at Thr668. Biochemistry. 2012 Oct 30; 51(43):8583-96. PMID: 23025283; PMCID: PMC3548994.
  24. Yoon SO, Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang K. JNK3 perpetuates metabolic stress induced by Aß peptides. Neuron. 2012 Sep 06; 75(5):824-37. PMID: 22958823; PMCID: PMC3438522.
  25. Luo T, Yu J, Nguyen J, Wang CR, Bristow RG, Jaffray DA, Zhou XZ, Lu KP, Lu QB. Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical, and lung cancers. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10175-80. PMID: 22685209; PMCID: PMC3387118.
  26. Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP. Prolyl isomerase Pin1 regulates neuronal differentiation via ß-catenin. Mol Cell Biol. 2012 Aug; 32(15):2966-78. PMID: 22645310; PMCID: PMC3434519.
  27. Min SH, Lau AW, Lee TH, Inuzuka H, Wei S, Huang P, Shaik S, Lee DY, Finn G, Balastik M, Chen CH, Luo M, Tron AE, Decaprio JA, Zhou XZ, Wei W, Lu KP. Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol Cell. 2012 Jun 29; 46(6):771-83. PMID: 22608923; PMCID: PMC3389221.
  28. Rangasamy V, Mishra R, Sondarva G, Das S, Lee TH, Bakowska JC, Tzivion G, Malter JS, Rana B, Lu KP, Kanthasamy A, Rana A. Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):8149-54. PMID: 22566623; PMCID: PMC3361382.
  29. Nakamura K, Greenwood A, Binder L, Bigio EH, Denial S, Nicholson L, Zhou XZ, Lu KP. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell. 2012 Mar 30; 149(1):232-44. PMID: 22464332; PMCID: PMC3601591.
  30. Liu KC, Yen CY, Wu RS, Yang JS, Lu HF, Lu KW, Lo C, Chen HY, Tang NY, Wu CC, Chung JG. The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells. Environ Toxicol. 2014 Apr; 29(4):428-39. PMID: 22431435.
    View in: PubMed
  31. Driver JA, Beiser A, Au R, Kreger BE, Splansky GL, Kurth T, Kiel DP, Lu KP, Seshadri S, Wolf PA. Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study. BMJ. 2012 Mar 12; 344:e1442. PMID: 22411920; PMCID: PMC3647385.
  32. Wang MX, Wu GF, Gu JL, Li L, Lu K, Yang D, Chen L, Zhang X, Luo FT, Michaels AD, Ma H. Defective T wave combined with incomplete right bundle branch block: a new electrocardiographic index for diagnosing atrial septal defect. Chin Med J (Engl). 2012 Mar; 125(6):1057-62. PMID: 22613531.
    View in: PubMed
  33. Pastorino L, Ma SL, Balastik M, Huang P, Pandya D, Nicholson L, Lu KP. Alzheimer's disease-related loss of Pin1 function influences the intracellular localization and the processing of AßPP. J Alzheimers Dis. 2012; 30(2):277-97. PMID: 22430533.
    View in: PubMed
  34. Ma SL, Pastorino L, Zhou XZ, Lu KP. Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3ß (GSK3ß) activity: novel mechanism for Pin1 to protect against Alzheimer disease. J Biol Chem. 2012 Mar 02; 287(10):6969-73. PMID: 22184106; PMCID: PMC3293570.
  35. Rajbhandari P, Finn G, Solodin NM, Singarapu KK, Sahu SC, Markley JL, Kadunc KJ, Ellison-Zelski SJ, Kariagina A, Haslam SZ, Lu KP, Alarid ET. Regulation of estrogen receptor a N-terminus conformation and function by peptidyl prolyl isomerase Pin1. Mol Cell Biol. 2012 Jan; 32(2):445-57. PMID: 22064478; PMCID: PMC3255769.
  36. Greenwood AI, Rogals MJ, De S, Lu KP, Kovrigin EL, Nicholson LK. Complete determination of the Pin1 catalytic domain thermodynamic cycle by NMR lineshape analysis. J Biomol NMR. 2011 Sep; 51(1-2):21-34. PMID: 21947912; PMCID: PMC3491808.
  37. Liou YC, Zhou XZ, Lu KP. Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem Sci. 2011 Oct; 36(10):501-14. PMID: 21852138; PMCID: PMC3185210.
  38. Yuan WC, Lee YR, Huang SF, Lin YM, Chen TY, Chung HC, Tsai CH, Chen HY, Chiang CT, Lai CK, Lu LT, Chen CH, Gu DL, Pu YS, Jou YS, Lu KP, Hsiao PW, Shih HM, Chen RH. A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. Cancer Cell. 2011 Aug 16; 20(2):214-28. PMID: 21840486.
    View in: PubMed
  39. Tun-Kyi A, Finn G, Greenwood A, Nowak M, Lee TH, Asara JM, Tsokos GC, Fitzgerald K, Israel E, Li X, Exley M, Nicholson LK, Lu KP. Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity. Nat Immunol. 2011 Jul 10; 12(8):733-41. PMID: 21743479; PMCID: PMC3298750.
  40. Lee TH, Pastorino L, Lu KP. Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease. Expert Rev Mol Med. 2011 Jun 20; 13:e21. PMID: 21682951.
    View in: PubMed
  41. Lu KW, Chen JC, Lai TY, Yang JS, Weng SW, Ma YS, Lin HY, Wu RS, Wu KC, Wood WG, Chung JG. Gypenosides suppress growth of human oral cancer SAS cells in vitro and in a murine xenograft model: the role of apoptosis mediated by caspase-dependent and caspase-independent pathways. Integr Cancer Ther. 2012 Jun; 11(2):129-40. PMID: 21665877.
    View in: PubMed
  42. Yao FJ, Huang YP, Lin H, Liu DH, Fan R, Liu YQ, Lu K, Deng CH, Sun XZ. [Smoking impairs endothelial function in ED patients]. Zhonghua Nan Ke Xue. 2011 May; 17(5):414-7. PMID: 21837950.
    View in: PubMed
  43. Lee TH, Chen CH, Suizu F, Huang P, Schiene-Fischer C, Daum S, Zhang YJ, Goate A, Chen RH, Zhou XZ, Lu KP. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. Mol Cell. 2011 Apr 22; 42(2):147-59. PMID: 21497122; PMCID: PMC3088080.
  44. Zhou XZ, Huang P, Shi R, Lee TH, Lu G, Zhang Z, Bronson R, Lu KP. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. J Clin Invest. 2011 Apr; 121(4):1266-82. PMID: 21436583; PMCID: PMC3069765.
  45. Driver JA, Lu KP. Pin1: a new genetic link between Alzheimer's disease, cancer and aging. Curr Aging Sci. 2010 Dec; 3(3):158-65. PMID: 20735350.
    View in: PubMed
  46. Soohoo CY, Shi R, Lee TH, Huang P, Lu KP, Zhou XZ. Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation. J Biol Chem. 2011 Feb 04; 286(5):3894-906. PMID: 21119197; PMCID: PMC3030390.
  47. Lu HF, Chie YJ, Yang MS, Lu KW, Fu JJ, Yang JS, Chen HY, Hsia TC, Ma CY, Ip SW, Chung JG. Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways. Hum Exp Toxicol. 2011 Aug; 30(8):1053-61. PMID: 20937639.
    View in: PubMed
  48. Ma SL, Tang NL, Tam CW, Lui VW, Lam LC, Chiu HF, Driver JA, Pastorino L, Lu KP. A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease. Neurobiol Aging. 2012 Apr; 33(4):804-13. PMID: 20580132; PMCID: PMC2988914.
  49. Lu KW, Chen JC, Lai TY, Yang JS, Weng SW, Ma YS, Tang NY, Lu PJ, Weng JR, Chung JG. Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells. In Vivo. 2010 May-Jun; 24(3):287-91. PMID: 20555000.
    View in: PubMed
  50. Fan G, Fan Y, Gupta N, Matsuura I, Liu F, Zhou XZ, Lu KP, Gélinas C. Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family. Cancer Res. 2009 Jun 01; 69(11):4589-97. PMID: 19458071; PMCID: PMC2741415.
  51. Ryo A, Wulf G, Lee TH, Lu KP. Pinning down HER2-ER crosstalk in SMRT regulation. Trends Biochem Sci. 2009 Apr; 34(4):162-5. PMID: 19269830.
    View in: PubMed
  52. Lam PB, Burga LN, Wu BP, Hofstatter EW, Lu KP, Wulf GM. Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability. Mol Cancer. 2008 Dec 15; 7:91. PMID: 19077306; PMCID: PMC2632646.
  53. Lee TH, Tun-Kyi A, Shi R, Lim J, Soohoo C, Finn G, Balastik M, Pastorino L, Wulf G, Zhou XZ, Lu KP. Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance. Nat Cell Biol. 2009 Jan; 11(1):97-105. PMID: 19060891; PMCID: PMC2699942.
  54. Balastik M, Ferraguti F, Pires-da Silva A, Lee TH, Alvarez-Bolado G, Lu KP, Gruss P. Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):12016-21. PMID: 18687884; PMCID: PMC2575299.
  55. Cole AR, Soutar MP, Rembutsu M, van Aalten L, Hastie CJ, McLauchlan H, Peggie M, Balastik M, Lu KP, Sutherland C. Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. J Biol Chem. 2008 Jun 27; 283(26):18227-37. PMID: 18460467; PMCID: PMC2440596.
  56. Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest. 2008 May; 118(5):1877-89. PMID: 18431510; PMCID: PMC2323189.
  57. Finn G, Lu KP. Phosphorylation-specific prolyl isomerase Pin1 as a new diagnostic and therapeutic target for cancer. Curr Cancer Drug Targets. 2008 May; 8(3):223-9. PMID: 18473735.
    View in: PubMed
  58. Hu J, Pan G, Xu J, Lu K, Dang X, Wu Z, Li Y, Zhou Z. [Characterization and analysis of mitochondrial protein frataxin in Nosema bombycis]. Wei Sheng Wu Xue Bao. 2008 May; 48(5):608-15. PMID: 18652292.
    View in: PubMed
  59. Lu KP, Zhou XZ. The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease. Nat Rev Mol Cell Biol. 2007 Nov; 8(11):904-16. PMID: 17878917.
    View in: PubMed
  60. Wildemann D, Hernandez Alvarez B, Stoller G, Zhou XZ, Lu KP, Erdmann F, Ferrari D, Fischer G. An essential role for Pin1 in Xenopus laevis embryonic development revealed by specific inhibitors. Biol Chem. 2007 Oct; 388(10):1103-11. PMID: 17937625.
    View in: PubMed
  61. Lu KP, Finn G, Lee TH, Nicholson LK. Prolyl cis-trans isomerization as a molecular timer. Nat Chem Biol. 2007 Oct; 3(10):619-29. PMID: 17876319.
    View in: PubMed
  62. Li QM, Tep C, Yune TY, Zhou XZ, Uchida T, Lu KP, Yoon SO. Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury. J Neurosci. 2007 Aug 01; 27(31):8395-404. PMID: 17670986; PMCID: PMC3401937.
  63. Zhang Y, Daum S, Wildemann D, Zhou XZ, Verdecia MA, Bowman ME, Lücke C, Hunter T, Lu KP, Fischer G, Noel JP. Structural basis for high-affinity peptide inhibition of human Pin1. ACS Chem Biol. 2007 May 22; 2(5):320-8. PMID: 17518432; PMCID: PMC2692202.
  64. Nicholson LK, Lu KP. Prolyl cis-trans Isomerization as a molecular timer in Crk signaling. Mol Cell. 2007 Feb 23; 25(4):483-5. PMID: 17317620.
    View in: PubMed
  65. Balastik M, Lim J, Pastorino L, Lu KP. Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism? Biochim Biophys Acta. 2007 Apr; 1772(4):422-9. PMID: 17317113; PMCID: PMC1868500.
  66. Liu DH, Wang Y, Liao XX, Xu MG, Wang JM, Yang Z, Chen L, Lü MD, Lu K, Tao J. Increased brachial-ankle pulse wave velocity is associated with impaired endothelial function in patients with coronary artery disease. Chin Med J (Engl). 2006 Nov 20; 119(22):1866-70. PMID: 17134584.
    View in: PubMed
  67. Pastorino L, Lu KP. Pathogenic mechanisms in Alzheimer's disease. Eur J Pharmacol. 2006 Sep 01; 545(1):29-38. PMID: 16904664.
    View in: PubMed
  68. Lu KP, Suizu F, Zhou XZ, Finn G, Lam P, Wulf G. Targeting carcinogenesis: a role for the prolyl isomerase Pin1? Mol Carcinog. 2006 Jun; 45(6):397-402. PMID: 16652378.
    View in: PubMed
  69. Saitoh T, Tun-Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, Akira S, Yamamoto N, Lu KP, Yamaoka S. Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat Immunol. 2006 Jun; 7(6):598-605. PMID: 16699525.
    View in: PubMed
  70. Yu L, Mohamed AJ, Vargas L, Berglöf A, Finn G, Lu KP, Smith CI. Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1. J Biol Chem. 2006 Jun 30; 281(26):18201-7. PMID: 16644721.
    View in: PubMed
  71. Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature. 2006 Mar 23; 440(7083):528-34. PMID: 16554819.
    View in: PubMed
  72. Chen SY, Wulf G, Zhou XZ, Rubin MA, Lu KP, Balk SP. Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction. Mol Cell Biol. 2006 Feb; 26(3):929-39. PMID: 16428447; PMCID: PMC1347015.
  73. Suizu F, Ryo A, Wulf G, Lim J, Lu KP. Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis. Mol Cell Biol. 2006 Feb; 26(4):1463-79. PMID: 16449657; PMCID: PMC1367188.
  74. Lee TH, Perrem K, Harper JW, Lu KP, Zhou XZ. The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. J Biol Chem. 2006 Jan 13; 281(2):759-68. PMID: 16275645.
    View in: PubMed
  75. Ryo A, Uemura H, Ishiguro H, Saitoh T, Yamaguchi A, Perrem K, Kubota Y, Lu KP, Aoki I. Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer. Clin Cancer Res. 2005 Oct 15; 11(20):7523-31. PMID: 16243827.
    View in: PubMed
  76. Sultana R, Boyd-Kimball D, Poon HF, Cai J, Pierce WM, Klein JB, Markesbery WR, Zhou XZ, Lu KP, Butterfield DA. Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiol Aging. 2006 Jul; 27(7):918-25. PMID: 15950321.
    View in: PubMed
  77. Wulf G, Finn G, Suizu F, Lu KP. Phosphorylation-specific prolyl isomerization: is there an underlying theme? Nat Cell Biol. 2005 May; 7(5):435-41. PMID: 15867923.
    View in: PubMed
  78. Dougherty MK, Müller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK. Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell. 2005 Jan 21; 17(2):215-24. PMID: 15664191.
    View in: PubMed
  79. Lim J, Lu KP. Pinning down phosphorylated tau and tauopathies. Biochim Biophys Acta. 2005 Jan 03; 1739(2-3):311-22. PMID: 15615648.
    View in: PubMed
  80. Wulf G, Garg P, Liou YC, Iglehart D, Lu KP. Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis. EMBO J. 2004 Aug 18; 23(16):3397-407. PMID: 15257284; PMCID: PMC514501.
  81. Kim KT, Ongusaha PP, Hong YK, Kurdistani SK, Nakamura M, Lu KP, Lee SW. Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. J Biol Chem. 2004 Sep 10; 279(37):38597-602. PMID: 15247272.
    View in: PubMed
  82. Bao L, Kimzey A, Sauter G, Sowadski JM, Lu KP, Wang DG. Prevalent overexpression of prolyl isomerase Pin1 in human cancers. Am J Pathol. 2004 May; 164(5):1727-37. PMID: 15111319; PMCID: PMC1615639.
  83. Lu KP. Pinning down cell signaling, cancer and Alzheimer's disease. Trends Biochem Sci. 2004 Apr; 29(4):200-9. PMID: 15082314.
    View in: PubMed
  84. Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell. 2003 Dec; 12(6):1413-26. PMID: 14690596.
    View in: PubMed
  85. Xu YX, Hirose Y, Zhou XZ, Lu KP, Manley JL. Pin1 modulates the structure and function of human RNA polymerase II. Genes Dev. 2003 Nov 15; 17(22):2765-76. PMID: 14600023; PMCID: PMC280625.
  86. Ayala G, Wang D, Wulf G, Frolov A, Li R, Sowadski J, Wheeler TM, Lu KP, Bao L. The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer. Cancer Res. 2003 Oct 01; 63(19):6244-51. PMID: 14559810.
    View in: PubMed
  87. Lu KP. Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics. Cancer Cell. 2003 Sep; 4(3):175-80. PMID: 14522251.
    View in: PubMed
  88. Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature. 2003 Jul 31; 424(6948):556-61. PMID: 12891359.
    View in: PubMed
  89. Zhou XZ, Perrem K, Lu KP. Role of Pin2/TRF1 in telomere maintenance and cell cycle control. J Cell Biochem. 2003 May 01; 89(1):19-37. PMID: 12682905.
    View in: PubMed
  90. Ryo A, Liou YC, Lu KP, Wulf G. Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer. J Cell Sci. 2003 Mar 01; 116(Pt 5):773-83. PMID: 12571275.
    View in: PubMed
  91. Lu KP, Liou YC, Vincent I. Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease. Bioessays. 2003 Feb; 25(2):174-81. PMID: 12539244.
    View in: PubMed
  92. Wulf G, Ryo A, Liou YC, Lu KP. The prolyl isomerase Pin1 in breast development and cancer. Breast Cancer Res. 2003; 5(2):76-82. PMID: 12631385; PMCID: PMC154150.
  93. Wulf GM, Liou YC, Ryo A, Lee SW, Lu KP. Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J Biol Chem. 2002 Dec 13; 277(50):47976-9. PMID: 12388558.
    View in: PubMed
  94. Zheng H, You H, Zhou XZ, Murray SA, Uchida T, Wulf G, Gu L, Tang X, Lu KP, Xiao ZX. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature. 2002 Oct 24; 419(6909):849-53. PMID: 12397361.
    View in: PubMed
  95. Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW, Lu KP. PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Mol Cell Biol. 2002 Aug; 22(15):5281-95. PMID: 12101225; PMCID: PMC133940.
  96. Lu KP, Liou YC, Zhou XZ. Pinning down proline-directed phosphorylation signaling. Trends Cell Biol. 2002 Apr; 12(4):164-72. PMID: 11978535.
    View in: PubMed
  97. Kops O, Zhou XZ, Lu KP. Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1. FEBS Lett. 2002 Feb 27; 513(2-3):305-11. PMID: 11904169.
    View in: PubMed
  98. Liou YC, Ryo A, Huang HK, Lu PJ, Bronson R, Fujimori F, Uchida T, Hunter T, Lu KP. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1335-40. PMID: 11805292; PMCID: PMC122191.
  99. Kishi S, Lu KP. A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells. J Biol Chem. 2002 Mar 01; 277(9):7420-9. PMID: 11744712.
    View in: PubMed
  100. Lu PJ, Zhou XZ, Liou YC, Noel JP, Lu KP. Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. J Biol Chem. 2002 Jan 25; 277(4):2381-4. PMID: 11723108.
    View in: PubMed
  101. Zhou XZ, Lu KP. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell. 2001 Nov 02; 107(3):347-59. PMID: 11701125.
    View in: PubMed
  102. Ryo A, Nakamura M, Wulf G, Liou YC, Lu KP. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol. 2001 Sep; 3(9):793-801. PMID: 11533658.
    View in: PubMed
  103. Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J. 2001 Jul 02; 20(13):3459-72. PMID: 11432833; PMCID: PMC125530.
  104. Zhou XZ, Kops O, Werner A, Lu PJ, Shen M, Stoller G, Küllertz G, Stark M, Fischer G, Lu KP. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. Mol Cell. 2000 Oct; 6(4):873-83. PMID: 11090625.
    View in: PubMed
  105. Zhou XZ, Lu PJ, Wulf G, Lu KP. Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism. Cell Mol Life Sci. 1999 Nov 30; 56(9-10):788-806. PMID: 11212339.
    View in: PubMed
  106. Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature. 1999 Jun 24; 399(6738):784-8. PMID: 10391244.
    View in: PubMed
  107. Lu PJ, Zhou XZ, Shen M, Lu KP. Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science. 1999 Feb 26; 283(5406):1325-8. PMID: 10037602.
    View in: PubMed
  108. Shen M, Stukenberg PT, Kirschner MW, Lu KP. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 1998 Mar 01; 12(5):706-20. PMID: 9499405; PMCID: PMC316589.
  109. Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12; 278(5345):1957-60. PMID: 9395400.
    View in: PubMed
  110. Shen M, Haggblom C, Vogt M, Hunter T, Lu KP. Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13618-23. PMID: 9391075; PMCID: PMC28355.
  111. Ranganathan R, Lu KP, Hunter T, Noel JP. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell. 1997 Jun 13; 89(6):875-86. PMID: 9200606.
    View in: PubMed
  112. Lu KP, Hanes SD, Hunter T. A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature. 1996 Apr 11; 380(6574):544-7. PMID: 8606777.
    View in: PubMed
  113. Lu KP, Hunter T. Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell. 1995 May 05; 81(3):413-24. PMID: 7736593.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Lu's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_