Harvard Catalyst Profiles

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Linda C. Hemphill, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gilbert RF, Cichowitz C, Bibangambah P, Kim JH, Hemphill LC, Yang IT, Sentongo RN, Kakuhikire B, Christiani DC, Tsai AC, Okello S, Siedner MJ, North CM. Lung function and atherosclerosis: a cross-sectional study of multimorbidity in rural Uganda. BMC Pulm Med. 2022 Jan 05; 22(1):12. PMID: 34983492; PMCID: PMC8728924.
    Citations:    Fields:    Translation:Humans
  2. Bibangambah P, Hemphill LC, Acan M, Tsai AC, Sentongo RN, Kim JH, Yang IT, Siedner MJ, Okello S. Prevalence and correlates of carotid plaque in a mixed HIV-serostatus cohort in Uganda. BMC Cardiovasc Disord. 2021 12 15; 21(1):593. PMID: 34911457; PMCID: PMC8672630.
    Citations:    Fields:    Translation:Humans
  3. Siedner MJ, Bibangambah P, Kim JH, Lankowski A, Chang JL, Yang IT, Kwon DS, North CM, Triant VA, Longenecker C, Ghoshhajra B, Peck RN, Sentongo RN, Gilbert R, Kakuhikire B, Boum Y, Haberer JE, Martin JN, Tracy R, Hunt PW, Bangsberg DR, Tsai AC, Hemphill LC, Okello S. Treated HIV Infection and Progression of Carotid Atherosclerosis in Rural Uganda: A Prospective Observational Cohort Study. J Am Heart Assoc. 2021 06 15; 10(12):e019994. PMID: 34096320; PMCID: PMC8477876.
    Citations: 3     Fields:    Translation:Humans
  4. Hemphill L, Goldberg A, Hovingh K, Cohen J, Karalis DG. Correction to: Recognition and Treatment of Homozygous Familial Hypercholesterolemia by Primary Care Physicians: a Survey from the National Lipid Association. J Gen Intern Med. 2020 Oct 27. PMID: 33111245.
    Citations:    Fields:    
  5. Goldberg AC, Dunbar RL, Hemphill L, Babirak SP, Wilson G, Wooten M, Iydroose M, Dacus K, Minchew H, Dutton JA, Moriarty PM. A retrospective analysis of clinical use of alirocumab in lipoprotein apheresis patients. J Clin Lipidol. 2020 Nov - Dec; 14(6):818-824. PMID: 32978095.
    Citations:    Fields:    Translation:Humans
  6. Yang IT, Hemphill LC, Kim JH, Bibangambah P, Sentongo R, Kakuhire B, Plutzky J, Boum Y, Tsai AC, Okello S, Siedner MJ. To fast or not to fast: Lipid measurement and cardiovascular disease risk estimation in rural sub-Saharan Africa. J Glob Health. 2020 Jun; 10(1):010407. PMID: 32257155; PMCID: PMC7101029.
    Citations:    Fields:    Translation:Humans
  7. Hemphill L, Goldberg A, Hovingh K, Cohen J, Karalis DG. Recognition and Treatment of Homozygous Familial Hypercholesterolemia by Primary Care Physicians: a Survey from the National Lipid Association. J Gen Intern Med. 2020 07; 35(7):2225-2227. PMID: 31950403.
    Citations:    Fields:    Translation:Humans
  8. Duell PB, Gidding SS, Andersen RL, Knickelbine T, Anderson L, Gianos E, Shrader P, Kindt I, O'Brien EC, McCann D, Hemphill LC, Ahmed CD, Martin SS, Larry JA, Ahmad ZS, Kullo IJ, Underberg JA, Guyton J, Thompson P, Wilemon K, Roe MT, Rader DJ, Cuchel M, Linton MF, Shapiro MD, Moriarty PM, Knowles JW. Longitudinal low density lipoprotein cholesterol goal achievement and cardiovascular outcomes among adult patients with familial hypercholesterolemia: The CASCADE FH registry. Atherosclerosis. 2019 10; 289:85-93. PMID: 31487564.
    Citations: 15     Fields:    Translation:Humans
  9. Witztum JL, Gaudet D, Freedman SD, Alexander VJ, Digenio A, Williams KR, Yang Q, Hughes SG, Geary RS, Arca M, Stroes ESG, Bergeron J, Soran H, Civeira F, Hemphill L, Tsimikas S, Blom DJ, O'Dea L, Bruckert E. Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome. N Engl J Med. 2019 08 08; 381(6):531-542. PMID: 31390500.
    Citations: 83     Fields:    Translation:HumansCTClinical Trials
  10. Muiru AN, Bibangambah P, Hemphill L, Sentongo R, Kim JH, Triant VA, Bangsberg DR, Tsai AC, Martin JN, Haberer JE, Boum Y, Plutzky J, Hunt PW, Okello S, Siedner MJ. Distribution and Performance of Cardiovascular Risk Scores in a Mixed Population of HIV-Infected and Community-Based HIV-Uninfected Individuals in Uganda. J Acquir Immune Defic Syndr. 2018 08 01; 78(4):458-464. PMID: 29652762; PMCID: PMC6019157.
    Citations: 9     Fields:    Translation:Humans
  11. Blom DJ, O'Dea L, Digenio A, Alexander VJ, Karwatowska-Prokopczuk E, Williams KR, Hemphill L, Muñiz-Grijalvo O, Santos RD, Baum S, Witztum JL. Characterizing familial chylomicronemia syndrome: Baseline data of the APPROACH study. J Clin Lipidol. 2018 Sep - Oct; 12(5):1234-1243.e5. PMID: 30318066.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  12. Mosepele M, Mohammed T, Mupfumi L, Moyo S, Bennett K, Lockman S, Hemphill LC, Triant VA. HIV disease is associated with increased biomarkers of endothelial dysfunction despite viral suppression on long-term antiretroviral therapy in Botswana. Cardiovasc J Afr. 2018 May/Jun 23; 29(3):155-161. PMID: 29771268.
    Citations: 9     Fields:    Translation:HumansCells
  13. Amrock SM, Duell PB, Knickelbine T, Martin SS, O'Brien EC, Watson KE, Mitri J, Kindt I, Shrader P, Baum SJ, Hemphill LC, Ahmed CD, Andersen RL, Kullo IJ, McCann D, Larry JA, Murray MF, Fishberg R, Guyton JR, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Underberg JA, Thompson P, Duffy D, Linton MF, Shapiro MD, Moriarty PM, Knowles JW, Ahmad ZS. Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry. Atherosclerosis. 2017 Dec; 267:19-26. PMID: 29080546.
    Citations: 15     Fields:    Translation:Humans
  14. Gaudet D, Digenio A, Alexander V, Arca M, Jones A, Stroes E, Bergeron J, Civeira F, Hemphill L, Blom D, Flaim J, Hughes S, Geary R, Tsimikas S, Witztum J, Bruckert E. The approach study: a randomized, double-blind, placebo-controlled, phase 3 study of volanesorsen administered subcutaneously to patients with familial chylomicronemia syndrome (FCS). Atherosclerosis. 2017 Aug; 263:e10. PMID: 29365426.
    Citations:    Fields:    
  15. Kelly E, Hemphill L. Lipoprotein(a): A Lipoprotein Whose Time Has Come. Curr Treat Options Cardiovasc Med. 2017 Jul; 19(7):48. PMID: 28508119.
    Citations: 4     
  16. Mosepele M, Hemphill LC, Moloi W, Moyo S, Nkele I, Makhema J, Bennett K, Triant VA, Lockman S. Pre-clinical carotid atherosclerosis and sCD163 among virally suppressed HIV patients in Botswana compared with uninfected controls. PLoS One. 2017; 12(6):e0179994. PMID: 28662159.
    Citations: 7     Fields:    Translation:HumansCells
  17. Mosepele M, Hemphill LC, Palai T, Nkele I, Bennett K, Lockman S, Triant VA. Cardiovascular disease risk prediction by the American College of Cardiology (ACC)/American Heart Association (AHA) Atherosclerotic Cardiovascular Disease (ASCVD) risk score among HIV-infected patients in sub-Saharan Africa. PLoS One. 2017; 12(2):e0172897. PMID: 28235058.
    Citations: 16     Fields:    Translation:Humans
  18. Feinstein MJ, Kim JH, Bibangambah P, Sentongo R, Martin JN, Tsai AC, Bangsberg DR, Hemphill L, Triant VA, Boum Y, Hunt PW, Okello S, Siedner MJ. Ideal Cardiovascular Health and Carotid Atherosclerosis in a Mixed Cohort of HIV-Infected and Uninfected Ugandans. AIDS Res Hum Retroviruses. 2017 01; 33(1):49-56. PMID: 27476547; PMCID: PMC5240009.
    Citations: 23     Fields:    Translation:Humans
  19. Ahmad ZS, Andersen RL, Andersen LH, O'Brien EC, Kindt I, Shrader P, Vasandani C, Newman CB, deGoma EM, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Kullo IJ, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW. US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry. J Clin Lipidol. 2016 Sep-Oct; 10(5):1223-9. PMID: 27678440.
    Citations: 13     Fields:    Translation:Humans
  20. deGoma EM, Ahmad ZS, O'Brien EC, Kindt I, Shrader P, Newman CB, Pokharel Y, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW. Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry. Circ Cardiovasc Genet. 2016 Jun; 9(3):240-9. PMID: 27013694.
    Citations: 46     Fields:    Translation:HumansCells
  21. Moriarty PM, Hemphill L. Lipoprotein Apheresis. Endocrinol Metab Clin North Am. 2016 Mar; 45(1):39-54. PMID: 26892996.
    Citations: 4     Fields:    
  22. Siedner MJ, Kim JH, Nakku RS, Hemphill L, Triant VA, Haberer JE, Martin JN, Boum Y, Kwon DS, Tsai AC, Hunt PW, Okello S, Bangsberg DR. HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda. AIDS. 2016 Feb 20; 30(4):667-70. PMID: 26636926; PMCID: PMC4733585.
    Citations: 20     Fields:    Translation:Humans
  23. Siedner MJ, Kim JH, Nakku RS, Bibangambah P, Hemphill L, Triant VA, Haberer JE, Martin JN, Mocello AR, Boum Y, Kwon DS, Tracy RP, Burdo T, Huang Y, Cao H, Okello S, Bangsberg DR, Hunt PW. Persistent Immune Activation and Carotid Atherosclerosis in HIV-Infected Ugandans Receiving Antiretroviral Therapy. J Infect Dis. 2016 Feb 01; 213(3):370-8. PMID: 26347573; PMCID: PMC4704672.
    Citations: 49     Fields:    Translation:Humans
  24. Moriarty PM, Hemphill L. Lipoprotein apheresis. Cardiol Clin. 2015 May; 33(2):197-208. PMID: 25939293.
    Citations: 6     Fields:    Translation:Humans
  25. van Wijk DF, Sjouke B, Figueroa A, Emami H, van der Valk FM, MacNabb MH, Hemphill LC, Schulte DM, Koopman MG, Lobatto ME, Verberne HJ, Fayad ZA, Kastelein JJ, Mulder WJ, Hovingh GK, Tawakol A, Stroes ES. Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia. J Am Coll Cardiol. 2014 Oct 07; 64(14):1418-26. PMID: 25277610.
    Citations: 29     Fields:    Translation:Humans
  26. Hemphill LC. The Cholesterol Lowering Atherosclerosis Study (CLAS): what it tells us about niacin/colestipol therapy. J Clin Lipidol. 2015 Jan-Feb; 9(1):11-3. PMID: 25670355.
    Citations: 1     Fields:    Translation:Humans
  27. O'Brien EC, Roe MT, Fraulo ES, Peterson ED, Ballantyne CM, Genest J, Gidding SS, Hammond E, Hemphill LC, Hudgins LC, Kindt I, Moriarty PM, Ross J, Underberg JA, Watson K, Pickhardt D, Rader DJ, Wilemon K, Knowles JW. Rationale and design of the familial hypercholesterolemia foundation CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia registry. Am Heart J. 2014 Mar; 167(3):342-349.e17. PMID: 24576518.
    Citations: 28     Fields:    Translation:HumansPHPublic Health
  28. Vishwanath R, Hemphill LC. Familial hypercholesterolemia and estimation of US patients eligible for low-density lipoprotein apheresis after maximally tolerated lipid-lowering therapy. J Clin Lipidol. 2014 Jan-Feb; 8(1):18-28. PMID: 24528684.
    Citations: 8     Fields:    Translation:Humans
  29. Bredella MA, Gerweck AV, Lin E, Landa MG, Torriani M, Schoenfeld DA, Hemphill LC, Miller KK. Effects of GH on body composition and cardiovascular risk markers in young men with abdominal obesity. J Clin Endocrinol Metab. 2013 Sep; 98(9):3864-72. PMID: 23824419; PMCID: PMC3763970.
    Citations: 30     Fields:    Translation:HumansCells
  30. Fitch KV, Looby SE, Rope A, Eneh P, Hemphill L, Lee H, Grinspoon SK. Effects of aging and smoking on carotid intima-media thickness in HIV-infection. AIDS. 2013 Jan 02; 27(1):49-57. PMID: 22874518; PMCID: PMC3690796.
    Citations: 15     Fields:    Translation:Humans
  31. Makimura H, Feldpausch MN, Rope AM, Hemphill LC, Torriani M, Lee H, Grinspoon SK. Metabolic effects of a growth hormone-releasing factor in obese subjects with reduced growth hormone secretion: a randomized controlled trial. J Clin Endocrinol Metab. 2012 Dec; 97(12):4769-79. PMID: 23015655; PMCID: PMC3513535.
    Citations: 18     Fields:    Translation:HumansCells
  32. Lin E, Wexler TL, Nachtigall L, Tritos N, Swearingen B, Hemphill L, Loeffler J, Biller BM, Klibanski A, Miller KK. Effects of growth hormone deficiency on body composition and biomarkers of cardiovascular risk after definitive therapy for acromegaly. Clin Endocrinol (Oxf). 2012 Sep; 77(3):430-8. PMID: 22315983.
    Citations: 13     Fields:    Translation:Humans
  33. Fitch K, Abbara S, Lee H, Stavrou E, Sacks R, Michel T, Hemphill L, Torriani M, Grinspoon S. Effects of lifestyle modification and metformin on atherosclerotic indices among HIV-infected patients with the metabolic syndrome. AIDS. 2012 Mar 13; 26(5):587-97. PMID: 22112605; PMCID: PMC3675446.
    Citations: 35     Fields:    Translation:Humans
  34. Bredella MA, Lin E, Brick DJ, Gerweck AV, Harrington LM, Torriani M, Thomas BJ, Schoenfeld DA, Breggia A, Rosen CJ, Hemphill LC, Wu Z, Rifai N, Utz AL, Miller KK. Effects of GH in women with abdominal adiposity: a 6-month randomized, double-blind, placebo-controlled trial. Eur J Endocrinol. 2012 Apr; 166(4):601-11. PMID: 22275471.
    Citations: 29     Fields:    Translation:Humans
  35. Brown WV, Brook R, Hemphill LC, Moriarty PM. The use of lipopheresis in the practice of clinical lipidology. J Clin Lipidol. 2012 Mar-Apr; 6(2):98-104. PMID: 22385541.
    Citations: 3     Fields:    Translation:Humans
  36. Thadhani R, Kisner T, Hagmann H, Bossung V, Noack S, Schaarschmidt W, Jank A, Kribs A, Cornely OA, Kreyssig C, Hemphill L, Rigby AC, Khedkar S, Lindner TH, Mallmann P, Stepan H, Karumanchi SA, Benzing T. Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia. Circulation. 2011 Aug 23; 124(8):940-50. PMID: 21810665.
    Citations: 98     Fields:    Translation:HumansCellsCTClinical Trials
  37. Fitch KV, Stavrou E, Looby SE, Hemphill L, Jaff MR, Grinspoon SK. Associations of cardiovascular risk factors with two surrogate markers of subclinical atherosclerosis: endothelial function and carotid intima media thickness. Atherosclerosis. 2011 Aug; 217(2):437-40. PMID: 21570076.
    Citations: 14     Fields:    Translation:Humans
  38. Makimura H, Stanley TL, Sun N, Connelly JM, Hemphill LC, Hrovat MI, Systrom DM, Grinspoon SK. Increased skeletal muscle phosphocreatine recovery after sub-maximal exercise is associated with increased carotid intima-media thickness. Atherosclerosis. 2011 Mar; 215(1):214-7. PMID: 21185022.
    Citations:    Fields:    Translation:HumansCells
  39. Makimura H, Stanley TL, Sun N, Connelly JM, Hemphill LC, Grinspoon SK. The relationship between reduced testosterone, stimulated growth hormone secretion and increased carotid intima-media thickness in obese men. Clin Endocrinol (Oxf). 2010 Nov; 73(5):622-9. PMID: 20681993.
    Citations: 1     Fields:    Translation:Humans
  40. Hemphill LC. Familial hypercholesterolemia: current treatment options and patient selection for low-density lipoprotein apheresis. J Clin Lipidol. 2010 Sep-Oct; 4(5):346-9. PMID: 21122676.
    Citations: 7     Fields:    Translation:Humans
  41. Miller KK, Wexler T, Fazeli P, Gunnell L, Graham GJ, Beauregard C, Hemphill L, Nachtigall L, Loeffler J, Swearingen B, Biller BM, Klibanski A. Growth hormone deficiency after treatment of acromegaly: a randomized, placebo-controlled study of growth hormone replacement. J Clin Endocrinol Metab. 2010 Feb; 95(2):567-77. PMID: 20061426; PMCID: PMC2840863.
    Citations: 19     Fields:    Translation:Humans
  42. Makimura H, Stanley T, Mun D, Chen C, Wei J, Connelly JM, Hemphill LC, Grinspoon SK. Reduced growth hormone secretion is associated with increased carotid intima-media thickness in obesity. J Clin Endocrinol Metab. 2009 Dec; 94(12):5131-8. PMID: 19837914; PMCID: PMC2795664.
    Citations: 20     Fields:    Translation:Humans
  43. Lo J, You SM, Canavan B, Liebau J, Beltrani G, Koutkia P, Hemphill L, Lee H, Grinspoon S. Low-dose physiological growth hormone in patients with HIV and abdominal fat accumulation: a randomized controlled trial. JAMA. 2008 Aug 06; 300(5):509-19. PMID: 18677023; PMCID: PMC2532757.
    Citations: 36     Fields:    Translation:Humans
  44. Utz AL, Yamamoto A, Hemphill L, Miller KK. Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women. J Clin Endocrinol Metab. 2008 Jul; 93(7):2507-14. PMID: 18445664; PMCID: PMC2453050.
    Citations: 34     Fields:    Translation:Humans
  45. Johnsen S, Dolan SE, Fitch KV, Kanter JR, Hemphill LC, Connelly JM, Lees RS, Lee H, Grinspoon S. Carotid intimal medial thickness in human immunodeficiency virus-infected women: effects of protease inhibitor use, cardiac risk factors, and the metabolic syndrome. J Clin Endocrinol Metab. 2006 Dec; 91(12):4916-24. PMID: 17003092; PMCID: PMC3205451.
    Citations: 39     Fields:    Translation:Humans
  46. Lo J, Dolan SE, Kanter JR, Hemphill LC, Connelly JM, Lees RS, Grinspoon SK. Effects of obesity, body composition, and adiponectin on carotid intima-media thickness in healthy women. J Clin Endocrinol Metab. 2006 May; 91(5):1677-82. PMID: 16522690; PMCID: PMC3210448.
    Citations: 28     Fields:    Translation:Humans
  47. Dolan SE, Hadigan C, Killilea KM, Sullivan MP, Hemphill L, Lees RS, Schoenfeld D, Grinspoon S. Increased cardiovascular disease risk indices in HIV-infected women. J Acquir Immune Defic Syndr. 2005 May 01; 39(1):44-54. PMID: 15851913.
    Citations: 62     Fields:    Translation:HumansCTClinical Trials
  48. Hodis HN, Mack WJ, Azen SP, Alaupovic P, Pogoda JM, LaBree L, Hemphill LC, Kramsch DM, Blankenhorn DH. Triglyceride- and cholesterol-rich lipoproteins have a differential effect on mild/moderate and severe lesion progression as assessed by quantitative coronary angiography in a controlled trial of lovastatin. Circulation. 1994 Jul; 90(1):42-9. PMID: 8026027.
    Citations: 38     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.