Harvard Catalyst Profiles

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Wilhelm Haas, Ph.D.

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shi L, Shen W, Davis MI, Kong K, Vu P, Saha SK, Adil R, Kreuzer J, Egan R, Lee TD, Greninger P, Shrimp JH, Zhao W, Wei TY, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney SE, Ho J, McClanaghan J, Murchie E, Crowther GS, Patnaik S, Boxer MB, Shen M, Ting DT, Kim WY, Stanger BZ, Deshpande V, Ferrone CR, Benes CH, Haas W, Hall MD, Bardeesy N. SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers. Nat Cancer. 2023 Mar 13. PMID: 36914816.
    Citations:    
  2. Boribong BP, LaSalle TJ, Bartsch YC, Ellett F, Loiselle ME, Davis JP, Gonye ALK, Sykes DB, Hajizadeh S, Kreuzer J, Pillai S, Haas W, Edlow AG, Fasano A, Alter G, Irimia D, Sade-Feldman M, Yonker LM. Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children. Cell Rep Med. 2022 12 20; 3(12):100848. PMID: 36476388; PMCID: PMC9676175.
    Citations: 4     Fields:    Translation:HumansCells
  3. Datta C, Truesdell SS, Wu KQ, Bukhari SIA, Ngue H, Buchanan B, Le Tonqueze O, Lee S, Kollu S, Granovetter MA, Boukhali M, Kreuzer J, Batool MS, Balaj L, Haas W, Vasudevan S. Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells. Sci Adv. 2022 Oct 28; 8(43):eabo1304. PMID: 36306353; PMCID: PMC9616492.
    Citations: 1     Fields:    
  4. Boieri M, Malishkevich A, Guennoun R, Marchese E, Kroon S, Trerice KE, Awad M, Park JH, Iyer S, Kreuzer J, Haas W, Rivera MN, Demehri S. CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation. J Exp Med. 2022 07 04; 219(7). PMID: 35657353; PMCID: PMC9170526.
    Citations: 4     Fields:    Translation:HumansCells
  5. Karabacak NM, Zheng Y, Dubash TD, Burr R, Micalizzi DS, Wittner BS, Lin M, Wiley DF, Comaills V, Emmons E, Niederhoffer KL, Ho U, Ukleja J, Che D, Stowe H, Nieman LT, Haas W, Stott SL, Lawrence MS, Ting DT, Miyamoto DT, Haber DA, Toner M, Maheswaran S. Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition. Cancer Res. 2022 03 15; 82(6):1084-1097. PMID: 35045985; PMCID: PMC8930560.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Boribong BP, LaSalle TJ, Bartsch YC, Ellett F, Loiselle ME, Davis JP, Gonye ALK, Hajizadeh S, Kreuzer J, Pillai S, Haas W, Edlow A, Fasano A, Alter G, Irimia D, Sade-Feldman M, Yonker LM. Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children. bioRxiv. 2021 Dec 20. PMID: 34981052; PMCID: PMC8722589.
    Citations: 1     
  7. Sîrbulescu RF, Mamidi A, Chan SC, Jin G, Boukhali M, Sobell D, Ilies I, Chung JY, Haas W, Whalen MJ, Sluder AE, Poznansky MC. B cells support the repair of injured tissues by adopting MyD88-dependent regulatory functions and phenotype. FASEB J. 2021 12; 35(12):e22019. PMID: 34792819; PMCID: PMC8756564.
    Citations:    Fields:    Translation:AnimalsCells
  8. He L, Jhong JH, Chen Q, Huang KY, Strittmatter K, Kreuzer J, DeRan M, Wu X, Lee TY, Slavov N, Haas W, Marneros AG. Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors. Cell Rep. 2021 11 02; 37(5):109955. PMID: 34731634; PMCID: PMC8783961.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  9. Rajasekaran S, Siddiqui J, Rakijas J, Nicolay B, Lin C, Khan E, Patel R, Morris R, Wyler E, Boukhali M, Balasubramanyam J, Ranjith Kumar R, Van Rechem C, Vogel C, Elchuri SV, Landthaler M, Obermayer B, Haas W, Dyson N, Miles W. Author Correction: Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses. Commun Biol. 2021 Sep 30; 4(1):1156. PMID: 34593978.
    Citations:    
  10. Rajasekaran S, Siddiqui J, Rakijas J, Nicolay B, Lin C, Khan E, Patel R, Morris R, Wyler E, Boukhali M, Balasubramanyam J, Ranjith Kumar R, Van Rechem C, Vogel C, Elchuri SV, Landthaler M, Obermayer B, Haas W, Dyson N, Miles W. Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses. Commun Biol. 2021 08 17; 4(1):977. PMID: 34404904; PMCID: PMC8371045.
    Citations: 1     Translation:HumansAnimalsCells
  11. Yonker LM, Gilboa T, Ogata AF, Senussi Y, Lazarovits R, Boribong BP, Bartsch YC, Loiselle M, Rivas MN, Porritt RA, Lima R, Davis JP, Farkas EJ, Burns MD, Young N, Mahajan VS, Hajizadeh S, Lopez XIH, Kreuzer J, Morris R, Martinez EE, Han I, Griswold K, Barry NC, Thompson DB, Church G, Edlow AG, Haas W, Pillai S, Arditi M, Alter G, Walt DR, Fasano A. Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier. J Clin Invest. 2021 07 15; 131(14). PMID: 34032635; PMCID: PMC8279585.
    Citations: 82     Fields:    Translation:HumansCells
  12. Zappia MP, Guarner A, Kellie-Smith N, Rogers A, Morris R, Nicolay B, Boukhali M, Haas W, Dyson NJ, Frolov MV. E2F/Dp inactivation in fat body cells triggers systemic metabolic changes. Elife. 2021 07 12; 10. PMID: 34251339; PMCID: PMC8298092.
    Citations:    Fields:    Translation:AnimalsCells
  13. Chu HP, Minajigi A, Chen Y, Morris R, Guh CY, Hsieh YH, Boukhali M, Haas W, Lee JT. iDRiP for the systematic discovery of proteins bound directly to noncoding RNA. Nat Protoc. 2021 07; 16(7):3672-3694. PMID: 34108731.
    Citations: 5     Fields:    Translation:AnimalsCells
  14. Carlyle BC, Kandigian SE, Kreuzer J, Das S, Trombetta BA, Kuo Y, Bennett DA, Schneider JA, Petyuk VA, Kitchen RR, Morris R, Nairn AC, Hyman BT, Haas W, Arnold SE. Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics. Neurobiol Aging. 2021 09; 105:99-114. PMID: 34052751.
    Citations: 6     Fields:    Translation:HumansCells
  15. Sequist LV, Skates SJ, Haas W. A New Era of Protein-Based Assays for Cancer Early Detection. J Thorac Oncol. 2021 02; 16(2):191-193. PMID: 33494925.
    Citations: 1     Fields:    Translation:Humans
  16. Vannam R, Sayilgan J, Ojeda S, Karakyriakou B, Hu E, Kreuzer J, Morris R, Herrera Lopez XI, Rai S, Haas W, Lawrence M, Ott CJ. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2021 04 15; 28(4):503-514.e12. PMID: 33400925.
    Citations: 19     Fields:    Translation:HumansCells
  17. Yu Y, Yang Y, Tan H, Boukhali M, Khatri A, Yu Y, Hua F, Liu L, Li M, Yang G, Dong Y, Zhang Y, Haas W, Xie Z. Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice. Anesthesiology. 2020 09; 133(3):595-610. PMID: 32701572; PMCID: PMC7429299.
    Citations: 25     Fields:    Translation:Animals
  18. Aeby E, Lee HG, Lee YW, Kriz A, Del Rosario BC, Oh HJ, Boukhali M, Haas W, Lee JT. Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover. Nat Cell Biol. 2020 09; 22(9):1116-1129. PMID: 32807903.
    Citations: 8     Fields:    Translation:AnimalsCells
  19. Badr CE, da Hora CC, Kirov AB, Tabet E, Amante R, Maksoud S, Nibbs AE, Fitzsimons E, Boukhali M, Chen JW, Chiu NHL, Nakano I, Haas W, Mazitschek R, Tannous BA. Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation. ACS Chem Biol. 2020 06 19; 15(6):1445-1454. PMID: 32338864.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  20. Lee S, Micalizzi D, Truesdell SS, Bukhari SIA, Boukhali M, Lombardi-Story J, Kato Y, Choo MK, Dey-Guha I, Ji F, Nicholson BT, Myers DT, Lee D, Mazzola MA, Raheja R, Langenbucher A, Haradhvala NJ, Lawrence MS, Gandhi R, Tiedje C, Diaz-Muñoz MD, Sweetser DA, Sadreyev R, Sykes D, Haas W, Haber DA, Maheswaran S, Vasudevan S. A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. Genome Biol. 2020 02 10; 21(1):33. PMID: 32039742; PMCID: PMC7011231.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  21. Ebright RY, Lee S, Wittner BS, Niederhoffer KL, Nicholson BT, Bardia A, Truesdell S, Wiley DF, Wesley B, Li S, Mai A, Aceto N, Vincent-Jordan N, Szabolcs A, Chirn B, Kreuzer J, Comaills V, Kalinich M, Haas W, Ting DT, Toner M, Vasudevan S, Haber DA, Maheswaran S, Micalizzi DS. Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis. Science. 2020 03 27; 367(6485):1468-1473. PMID: 32029688.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  22. Peshkin L, Boukhali M, Haas W, Kirschner MW, Yampolsky LY. Quantitative Proteomics Reveals Remodeling of Protein Repertoire Across Life Phases of Daphnia pulex. Proteomics. 2019 12; 19(24):e1900155. PMID: 31697011.
    Citations:    Fields:    Translation:Animals
  23. Iglesias N, Paulo JA, Tatarakis A, Wang X, Edwards AL, Bhanu NV, Garcia BA, Haas W, Gygi SP, Moazed D. Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance. Mol Cell. 2020 01 02; 77(1):51-66.e8. PMID: 31784357.
    Citations: 28     Fields:    Translation:AnimalsCells
  24. Strasser SD, Ghazi PC, Starchenko A, Boukhali M, Edwards A, Suarez-Lopez L, Lyons J, Changelian PS, Monahan JB, Jacobsen J, Brubaker DK, Joughin BA, Yaffe MB, Haas W, Lauffenburger DA, Haigis KM. Substrate-based kinase activity inference identifies MK2 as driver of colitis. Integr Biol (Camb). 2019 11 26; 11(7):301-314. PMID: 31617572; PMCID: PMC7208439.
    Citations: 6     Fields:    Translation:AnimalsCells
  25. Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2019 Nov; 575(7783):E5. PMID: 31695192.
    Citations:    Fields:    
  26. Kreuzer J, Edwards A, Haas W. Multiplexed quantitative phosphoproteomics of cell line and tissue samples. Methods Enzymol. 2019; 626:41-65. PMID: 31606085.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  27. Tajima K, Matsuda S, Yae T, Drapkin BJ, Morris R, Boukhali M, Niederhoffer K, Comaills V, Dubash T, Nieman L, Guo H, Magnus NKC, Dyson N, Shioda T, Haas W, Haber DA, Maheswaran S. SETD1A protects from senescence through regulation of the mitotic gene expression program. Nat Commun. 2019 06 28; 10(1):2854. PMID: 31253781.
    Citations: 19     Fields:    Translation:HumansCells
  28. Ligorio M, Sil S, Malagon-Lopez J, Nieman LT, Misale S, Di Pilato M, Ebright RY, Karabacak MN, Kulkarni AS, Liu A, Vincent Jordan N, Franses JW, Philipp J, Kreuzer J, Desai N, Arora KS, Rajurkar M, Horwitz E, Neyaz A, Tai E, Magnus NKC, Vo KD, Yashaswini CN, Marangoni F, Boukhali M, Fatherree JP, Damon LJ, Xega K, Desai R, Choz M, Bersani F, Langenbucher A, Thapar V, Morris R, Wellner UF, Schilling O, Lawrence MS, Liss AS, Rivera MN, Deshpande V, Benes CH, Maheswaran S, Haber DA, Fernandez-Del-Castillo C, Ferrone CR, Haas W, Aryee MJ, Ting DT. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. Cell. 2019 06 27; 178(1):160-175.e27. PMID: 31155233; PMCID: PMC6697165.
    Citations: 204     Fields:    Translation:HumansAnimalsCells
  29. Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer KJ, Cedillo L, Zhang Y, Li S, Kacergis MC, Webster CM, Fejes-Toth G, Naray-Fejes-Toth A, Das S, Hansen M, Haas W, Soukas AA. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Cell. 2019 04 04; 177(2):299-314.e16. PMID: 30929899; PMCID: PMC6610881.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  30. Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L. Erratum: Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes Dev. 2019 02 01; 33(3-4):253. PMID: 30709902; PMCID: PMC6362811.
    Citations: 1     Fields:    
  31. Sanidas I, Morris R, Fella KA, Rumde PH, Boukhali M, Tai EC, Ting DT, Lawrence MS, Haas W, Dyson NJ. A Code of Mono-phosphorylation Modulates the Function of RB. Mol Cell. 2019 03 07; 73(5):985-1000.e6. PMID: 30711375; PMCID: PMC6424368.
    Citations: 45     Fields:    Translation:HumansCells
  32. Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L. Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes Dev. 2019 01 01; 33(1-2):75-89. PMID: 30567999; PMCID: PMC6317314.
    Citations: 9     Fields:    Translation:HumansCells
  33. Motnenko A, Liang CC, Yang D, Lopez-Martinez D, Yoshikawa Y, Zhan B, Ward KE, Tian J, Haas W, Spingardi P, Kessler BM, Kriaucionis S, Gygi SP, Cohn MA. Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein. PLoS Genet. 2018 10; 14(10):e1007643. PMID: 30335751; PMCID: PMC6193622.
    Citations: 12     Fields:    Translation:HumansCells
  34. Chen B, Niu J, Kreuzer J, Zheng B, Jarugumilli GK, Haas W, Wu X. Auto-fatty acylation of transcription factor RFX3 regulates ciliogenesis. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8403-E8412. PMID: 30127002; PMCID: PMC6130365.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  35. Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, Nomura DK, Haas W, Bardeesy N. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol. 2018 07; 20(7):811-822. PMID: 29941929; PMCID: PMC6044476.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  36. Perugino CA, AlSalem SB, Mattoo H, Della-Torre E, Mahajan V, Ganesh G, Allard-Chamard H, Wallace Z, Montesi SB, Kreuzer J, Haas W, Stone JH, Pillai S. Identification of galectin-3 as an autoantigen in patients with IgG4-related disease. J Allergy Clin Immunol. 2019 02; 143(2):736-745.e6. PMID: 29852256; PMCID: PMC6265117.
    Citations: 45     Fields:    Translation:HumansCells
  37. Lyons J, Brubaker DK, Ghazi PC, Baldwin KR, Edwards A, Boukhali M, Strasser SD, Suarez-Lopez L, Lin YJ, Yajnik V, Kissil JL, Haas W, Lauffenburger DA, Haigis KM. Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis. Sci Signal. 2018 02 27; 11(519). PMID: 29487189; PMCID: PMC6719711.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  38. Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, Winter GE, Gray NS. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 02; 14(2):163-170. PMID: 29251720; PMCID: PMC5912898.
    Citations: 157     Fields:    Translation:HumansCells
  39. Guarner A, Morris R, Korenjak M, Boukhali M, Zappia MP, Van Rechem C, Whetstine JR, Ramaswamy S, Zou L, Frolov MV, Haas W, Dyson NJ. E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. Dev Cell. 2017 12 18; 43(6):689-703.e5. PMID: 29233476; PMCID: PMC5901703.
    Citations: 11     Fields:    Translation:AnimalsCells
  40. Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM. TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov. 2017 11; 7(11):1336-1353. PMID: 28974511.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  41. Lapek JD, Greninger P, Morris R, Amzallag A, Pruteanu-Malinici I, Benes CH, Haas W. Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities. Nat Biotechnol. 2017 Oct; 35(10):983-989. PMID: 28892078; PMCID: PMC5683351.
    Citations: 68     Fields:    Translation:HumansCells
  42. Chu HP, Cifuentes-Rojas C, Kesner B, Aeby E, Lee HG, Wei C, Oh HJ, Boukhali M, Haas W, Lee JT. TERRA RNA Antagonizes ATRX and Protects Telomeres. Cell. 2017 Jun 29; 170(1):86-101.e16. PMID: 28666128; PMCID: PMC5552367.
    Citations: 115     Fields:    Translation:AnimalsCells
  43. Laviolette LA, Mermoud J, Calvo IA, Olson N, Boukhali M, Steinlein OK, Roider E, Sattler EC, Huang D, Teh BT, Motamedi M, Haas W, Iliopoulos O. Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein. Nat Commun. 2017 06 28; 8:15866. PMID: 28656962; PMCID: PMC5493755.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  44. Li J, Haas W, Jackson K, Kuru E, Jewett MC, Fan ZH, Gygi S, Church GM. Cogenerating Synthetic Parts toward a Self-Replicating System. ACS Synth Biol. 2017 07 21; 6(7):1327-1336. PMID: 28330337.
    Citations: 18     Fields:    Translation:Cells
  45. Zheng Y, Miyamoto DT, Wittner BS, Sullivan JP, Aceto N, Jordan NV, Yu M, Karabacak NM, Comaills V, Morris R, Desai R, Desai N, Emmons E, Milner JD, Lee RJ, Wu CL, Sequist LV, Haas W, Ting DT, Toner M, Ramaswamy S, Maheswaran S, Haber DA. Expression of ß-globin by cancer cells promotes cell survival during blood-borne dissemination. Nat Commun. 2017 02 09; 8:14344. PMID: 28181495; PMCID: PMC5321792.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  46. Buisson R, Niraj J, Rodrigue A, Ho CK, Kreuzer J, Foo TK, Hardy EJ, Dellaire G, Haas W, Xia B, Masson JY, Zou L. Coupling of Homologous Recombination and the Checkpoint by ATR. Mol Cell. 2017 Jan 19; 65(2):336-346. PMID: 28089683; PMCID: PMC5496772.
    Citations: 80     Fields:    Translation:HumansCells
  47. Parasuraman P, Mulligan P, Walker JA, Li B, Boukhali M, Haas W, Bernards A. Interaction of p190A RhoGAP with eIF3A and Other Translation Preinitiation Factors Suggests a Role in Protein Biosynthesis. J Biol Chem. 2017 02 17; 292(7):2679-2689. PMID: 28007963.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  48. McEwan DL, Feinbaum RL, Stroustrup N, Haas W, Conery AL, Anselmo A, Sadreyev R, Ausubel FM. Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway. BMC Biol. 2016 12 07; 14(1):105. PMID: 27927200; PMCID: PMC5143455.
    Citations: 15     Fields:    Translation:AnimalsCells
  49. Comaills V, Kabeche L, Morris R, Buisson R, Yu M, Madden MW, LiCausi JA, Boukhali M, Tajima K, Pan S, Aceto N, Sil S, Zheng Y, Sundaresan T, Yae T, Jordan NV, Miyamoto DT, Ting DT, Ramaswamy S, Haas W, Zou L, Haber DA, Maheswaran S. Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition. Cell Rep. 2016 12 06; 17(10):2632-2647. PMID: 27926867.
    Citations: 51     Fields:    Translation:HumansCells
  50. Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016 11 17; 539(7629):390-395. PMID: 27799657; PMCID: PMC5988435.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  51. German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG, Haigis MC. PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Mol Cell. 2016 09 15; 63(6):1006-20. PMID: 27635760; PMCID: PMC5040345.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  52. Jordan NV, Bardia A, Wittner BS, Benes C, Ligorio M, Zheng Y, Yu M, Sundaresan TK, Licausi JA, Desai R, O'Keefe RM, Ebright RY, Boukhali M, Sil S, Onozato ML, Iafrate AJ, Kapur R, Sgroi D, Ting DT, Toner M, Ramaswamy S, Haas W, Maheswaran S, Haber DA. HER2 expression identifies dynamic functional states within circulating breast cancer cells. Nature. 2016 09 01; 537(7618):102-106. PMID: 27556950; PMCID: PMC5161614.
    Citations: 168     Fields:    Translation:HumansCells
  53. Bukhari SIA, Truesdell SS, Lee S, Kollu S, Classon A, Boukhali M, Jain E, Mortensen RD, Yanagiya A, Sadreyev RI, Haas W, Vasudevan S. A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence. Mol Cell. 2016 Mar 03; 61(5):760-773. PMID: 26942679; PMCID: PMC4811377.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  54. Edwards A, Haas W. Multiplexed Quantitative Proteomics for High-Throughput Comprehensive Proteome Comparisons of Human Cell Lines. Methods Mol Biol. 2016; 1394:1-13. PMID: 26700037.
    Citations: 39     Fields:    Translation:HumansCells
  55. Solé X, Alves CP, Dey-Guha I, Ritsma L, Boukhali M, Lee JH, Chowdhury J, Ross KN, Haas W, Vasudevan S, Ramaswamy S. AKT Inhibition Promotes Nonautonomous Cancer Cell Survival. Mol Cancer Ther. 2016 Jan; 15(1):142-53. PMID: 26637368; PMCID: PMC4707053.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  56. Peshkin L, Wühr M, Pearl E, Haas W, Freeman RM, Gerhart JC, Klein AM, Horb M, Gygi SP, Kirschner MW. On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development. Dev Cell. 2015 Nov 09; 35(3):383-94. PMID: 26555057; PMCID: PMC4776761.
    Citations: 98     Fields:    Translation:AnimalsCells
  57. Braun CR, Bird GH, Wühr M, Erickson BK, Rad R, Walensky LD, Gygi SP, Haas W. Generation of multiple reporter ions from a single isobaric reagent increases multiplexing capacity for quantitative proteomics. Anal Chem. 2015 Oct 06; 87(19):9855-63. PMID: 26308379; PMCID: PMC4890644.
    Citations: 15     Fields:    
  58. Nicolay BN, Danielian PS, Kottakis F, Lapek JD, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. Genes Dev. 2015 Sep 01; 29(17):1875-89. PMID: 26314710; PMCID: PMC4573859.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  59. Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015 Aug 20; 524(7565):361-5. PMID: 26168401; PMCID: PMC5086585.
    Citations: 405     Fields:    Translation:HumansAnimalsCells
  60. Minajigi A, Froberg J, Wei C, Sunwoo H, Kesner B, Colognori D, Lessing D, Payer B, Boukhali M, Haas W, Lee JT. Chromosomes. A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation. Science. 2015 Jul 17; 349(6245). PMID: 26089354; PMCID: PMC4845908.
    Citations: 208     Fields:    Translation:AnimalsCells
  61. Liang CC, Zhan B, Yoshikawa Y, Haas W, Gygi SP, Cohn MA. UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway. Cell Rep. 2015 Mar 31; 10(12):1947-56. PMID: 25801034; PMCID: PMC4386029.
    Citations: 51     Fields:    Translation:HumansCells
  62. Van Rechem C, Black JC, Boukhali M, Aryee MJ, Gräslund S, Haas W, Benes CH, Whetstine JR. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar; 5(3):255-63. PMID: 25564516; PMCID: PMC4355328.
    Citations: 32     Fields:    Translation:HumansCells
  63. Qendro V, Lundgren DH, Rezaul K, Mahony F, Ferrell N, Bi A, Latifi A, Chowdhury D, Gygi S, Haas W, Wilson L, Murphy M, Han DK. Large-scale proteomic characterization of melanoma expressed proteins reveals nestin and vimentin as biomarkers that can potentially distinguish melanoma subtypes. J Proteome Res. 2014 Nov 07; 13(11):5031-40. PMID: 25322343.
    Citations: 12     Fields:    Translation:HumansCells
  64. McAlister GC, Nusinow DP, Jedrychowski MP, Wühr M, Huttlin EL, Erickson BK, Rad R, Haas W, Gygi SP. MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes. Anal Chem. 2014 Jul 15; 86(14):7150-8. PMID: 24927332; PMCID: PMC4215866.
    Citations: 532     Fields:    Translation:HumansCells
  65. Tolonen AC, Haas W. Quantitative proteomics using reductive dimethylation for stable isotope labeling. J Vis Exp. 2014 Jul 01; (89). PMID: 25045933.
    Citations: 27     Fields:    Translation:AnimalsCells
  66. McAllister FE, Niepel M, Haas W, Huttlin E, Sorger PK, Gygi SP. Mass spectrometry based method to increase throughput for kinome analyses using ATP probes. Anal Chem. 2013 May 07; 85(9):4666-74. PMID: 23607489.
    Citations: 14     Fields:    Translation:HumansCells
  67. Wilson-Grady JT, Haas W, Gygi SP. Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods. 2013 Jun 15; 61(3):277-86. PMID: 23567750.
    Citations: 38     Fields:    Translation:AnimalsCells
  68. Aukrust I, Bjørkhaug L, Negahdar M, Molnes J, Johansson BB, Müller Y, Haas W, Gygi SP, Søvik O, Flatmark T, Kulkarni RN, Njølstad PR. SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. J Biol Chem. 2013 Feb 22; 288(8):5951-62. PMID: 23297408.
    Citations: 20     Fields:    Translation:AnimalsCells
  69. Wühr M, Haas W, McAlister GC, Peshkin L, Rad R, Kirschner MW, Gygi SP. Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster. Anal Chem. 2012 Nov 06; 84(21):9214-21. PMID: 23098179.
    Citations: 54     Fields:    Translation:Humans
  70. McAlister GC, Huttlin EL, Haas W, Ting L, Jedrychowski MP, Rogers JC, Kuhn K, Pike I, Grothe RA, Blethrow JD, Gygi SP. Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses. Anal Chem. 2012 Sep 04; 84(17):7469-78. PMID: 22880955.
    Citations: 275     Fields:    Translation:HumansAnimalsCells
  71. Blättler SM, Cunningham JT, Verdeguer F, Chim H, Haas W, Liu H, Romanino K, Rüegg MA, Gygi SP, Shi Y, Puigserver P. Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metab. 2012 Apr 04; 15(4):505-17. PMID: 22482732.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  72. Wang HH, Huang PY, Xu G, Haas W, Marblestone A, Li J, Gygi SP, Forster AC, Jewett MC, Church GM. Multiplexed in vivo His-tagging of enzyme pathways for in vitro single-pot multienzyme catalysis. ACS Synth Biol. 2012 Feb 17; 1(2):43-52. PMID: 22737598.
    Citations: 39     Fields:    Translation:Cells
  73. Ting L, Rad R, Gygi SP, Haas W. MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics. Nat Methods. 2011 Oct 02; 8(11):937-40. PMID: 21963607.
    Citations: 431     Fields:    Translation:HumansAnimalsCells
  74. Jedrychowski MP, Huttlin EL, Haas W, Sowa ME, Rad R, Gygi SP. Evaluation of HCD- and CID-type fragmentation within their respective detection platforms for murine phosphoproteomics. Mol Cell Proteomics. 2011 Dec; 10(12):M111.009910. PMID: 21917720.
    Citations: 69     Fields:    Translation:AnimalsCells
  75. Finley LW, Haas W, Desquiret-Dumas V, Wallace DC, Procaccio V, Gygi SP, Haigis MC. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS One. 2011; 6(8):e23295. PMID: 21858060.
    Citations: 158     Fields:    Translation:HumansAnimalsCells
  76. Wu R, Haas W, Dephoure N, Huttlin EL, Zhai B, Sowa ME, Gygi SP. A large-scale method to measure absolute protein phosphorylation stoichiometries. Nat Methods. 2011 Jul 03; 8(8):677-83. PMID: 21725298.
    Citations: 139     Fields:    Translation:Cells
  77. Wu R, Dephoure N, Haas W, Huttlin EL, Zhai B, Sowa ME, Gygi SP. Correct interpretation of comprehensive phosphorylation dynamics requires normalization by protein expression changes. Mol Cell Proteomics. 2011 Aug; 10(8):M111.009654. PMID: 21551504.
    Citations: 87     Fields:    Translation:AnimalsCells
  78. Tolonen AC, Haas W, Chilaka AC, Aach J, Gygi SP, Church GM. Proteome-wide systems analysis of a cellulosic biofuel-producing microbe. Mol Syst Biol. 2011 Jan 18; 7:461. PMID: 21245846.
    Citations: 43     Fields:    Translation:Cells
  79. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villén J, Haas W, Sowa ME, Gygi SP. A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23; 143(7):1174-89. PMID: 21183079.
    Citations: 863     Fields:    Translation:AnimalsCells
  80. Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15299-304. PMID: 20686112.
    Citations: 87     Fields:    Translation:HumansCells
  81. Aguiar M, Haas W, Beausoleil SA, Rush J, Gygi SP. Gas-phase rearrangements do not affect site localization reliability in phosphoproteomics data sets. J Proteome Res. 2010 Jun 04; 9(6):3103-7. PMID: 20377248.
    Citations: 17     Fields:    Translation:Cells
  82. Kee Y, Yang K, Cohn MA, Haas W, Gygi SP, D'Andrea AD. WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. J Biol Chem. 2010 Apr 09; 285(15):11252-7. PMID: 20147737.
    Citations: 49     Fields:    Translation:HumansCells
  83. Rodgers JT, Haas W, Gygi SP, Puigserver P. Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab. 2010 Jan; 11(1):23-34. PMID: 20074525; PMCID: PMC2807620.
    Citations: 66     Fields:    Translation:AnimalsCells
  84. Roelofs J, Park S, Haas W, Tian G, McAllister FE, Huo Y, Lee BH, Zhang F, Shi Y, Gygi SP, Finley D. Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature. 2009 Jun 11; 459(7248):861-5. PMID: 19412159.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  85. Kelly TJ, Lerin C, Haas W, Gygi SP, Puigserver P. GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J Biol Chem. 2009 Jul 24; 284(30):19945-52. PMID: 19491097.
    Citations: 64     Fields:    Translation:HumansCells
  86. Besche HC, Haas W, Gygi SP, Goldberg AL. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry. 2009 Mar 24; 48(11):2538-49. PMID: 19182904.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  87. Cohn MA, Kee Y, Haas W, Gygi SP, D'Andrea AD. UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem. 2009 Feb 20; 284(8):5343-51. PMID: 19075014.
    Citations: 103     Fields:    Translation:HumansCells
  88. Bakalarski CE, Elias JE, Villén J, Haas W, Gerber SA, Everley PA, Gygi SP. The impact of peptide abundance and dynamic range on stable-isotope-based quantitative proteomic analyses. J Proteome Res. 2008 Nov; 7(11):4756-65. PMID: 18798661.
    Citations: 64     Fields:    Translation:HumansCells
  89. Selenko P, Frueh DP, Elsaesser SJ, Haas W, Gygi SP, Wagner G. In situ observation of protein phosphorylation by high-resolution NMR spectroscopy. Nat Struct Mol Biol. 2008 Mar; 15(3):321-9. PMID: 18297086.
    Citations: 59     Fields:    Translation:AnimalsCells
  90. Cohn MA, Kowal P, Yang K, Haas W, Huang TT, Gygi SP, D'Andrea AD. A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol Cell. 2007 Dec 14; 28(5):786-97. PMID: 18082604.
    Citations: 197     Fields:    Translation:HumansCells
  91. Bakalarski CE, Haas W, Dephoure NE, Gygi SP. The effects of mass accuracy, data acquisition speed, and search algorithm choice on peptide identification rates in phosphoproteomics. Anal Bioanal Chem. 2007 Nov; 389(5):1409-19. PMID: 17874083.
    Citations: 31     Fields:    
  92. Everley PA, Gartner CA, Haas W, Saghatelian A, Elias JE, Cravatt BF, Zetter BR, Gygi SP. Assessing enzyme activities using stable isotope labeling and mass spectrometry. Mol Cell Proteomics. 2007 Oct; 6(10):1771-7. PMID: 17627935.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  93. Bühler M, Haas W, Gygi SP, Moazed D. RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing. Cell. 2007 May 18; 129(4):707-21. PMID: 17512405.
    Citations: 133     Fields:    Translation:AnimalsCells
  94. Li X, Gerber SA, Rudner AD, Beausoleil SA, Haas W, Villén J, Elias JE, Gygi SP. Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae. J Proteome Res. 2007 Mar; 6(3):1190-7. PMID: 17330950.
    Citations: 139     Fields:    Translation:Cells
  95. Haas W, Faherty BK, Gerber SA, Elias JE, Beausoleil SA, Bakalarski CE, Li X, Villén J, Gygi SP. Optimization and use of peptide mass measurement accuracy in shotgun proteomics. Mol Cell Proteomics. 2006 Jul; 5(7):1326-37. PMID: 16635985.
    Citations: 149     Fields:    Translation:Animals
  96. Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W, Gygi SP, Ploegh HL, Bernards R, D'Andrea AD. Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol. 2006 Apr; 8(4):339-47. PMID: 16531995.
    Citations: 286     Fields:    Translation:HumansCells
  97. Mortensen EM, Haas W, Gygi M, Gygi SP, Kellogg DR. Cdc28-dependent regulation of the Cdc5/Polo kinase. Curr Biol. 2005 Nov 22; 15(22):2033-7. PMID: 16303563.
    Citations: 40     Fields:    Translation:AnimalsCells
  98. Elias JE, Haas W, Faherty BK, Gygi SP. Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations. Nat Methods. 2005 Sep; 2(9):667-75. PMID: 16118637.
    Citations: 269     Fields:    
  99. Harvey SL, Charlet A, Haas W, Gygi SP, Kellogg DR. Cdk1-dependent regulation of the mitotic inhibitor Wee1. Cell. 2005 Aug 12; 122(3):407-20. PMID: 16096060.
    Citations: 111     Fields:    Translation:AnimalsCells
  100. Gilmore MS, Haas W. The selective advantage of microbial fratricide. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8401-2. PMID: 15939890; PMCID: PMC1150870.
    Citations: 11     Fields:    Translation:Cells
  101. Schmidt M, Haas W, Crosas B, Santamaria PG, Gygi SP, Walz T, Finley D. The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol. 2005 Apr; 12(4):294-303. PMID: 15778719.
    Citations: 94     Fields:    Translation:AnimalsCells
  102. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005 Mar 03; 434(7029):113-8. PMID: 15744310.
    Citations: 1420     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.