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C. Keith Ozaki, M.D.

Title
Institution
Department
Address
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Biography
1980 - 1982
William Randolph Hearst Scholar
1982 - 1986
Harry S. Truman Scholar
1993
William J. von Liebig Foundation Award
2000
Lester R. Dragstedt Physician Scientist Award
2000 - 2005
William J. von Liebig Award
2001
Lifeline Foundation E. J. Wylie Traveling Fellowship
2004
Lester R. Dragstedt Physician Scientist Award

Overview
Dr. Ozaki was recruited out of his training to the University of Florida in 1997 primarily to serve as an academic clinical vascular surgeon and to build the vascular research program. His clinical and teaching expertise is largely complex open carotid, aortic, and lower extremity arterial surgery. By 2000 he ascended to Chief, Vascular Surgery at the Malcom Randall VAMC, and under his direction the Section built case volume while consistently earning high ratings in quality assessments such as the National Surgical Quality Improvement Program and resident teaching evaluations. Then in 2006 he was promoted to Chief, Surgical Service for the North Florida/South Georgia Veterans Health System, where his push for excellence in surgical throughput and quality continued. This complex institution stands as one of the largest VA Systems in the nation, and he supervised more than one hundred employees on his Service. Simultaneously during his eleven years in Florida he built the Vascular Surgery research program to the point of five well-funded investigators (four by the National Institutes of Health). Dr. Ozaki’s basic research efforts broadly aim to delineate the mechanisms by which physical forces alter the morphology of the blood vessel wall. He holds expertise specifically in the adaptations of the vein bypass graft, an extreme example of acute perturbation of the hemodynamic environment combined with vascular trauma. His recent investigative efforts have focused on inflammatory driven mechanisms of these adaptations. Future research directions will expand (in both animal models and humans) this foundation of knowledge via enhanced in vivo imaging of the blood vessel wall, and robust analyses of the longitudinal interplay between local hemodynamic factors and biologic mediators such as adipose tissue. In 2008 he was recruited to the Brigham and Women’s Hospital to serve as the Director, Vascular Surgery Research and to function as a clinician in the new constructed Shapiro Cardiovascular Center.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sharma G, Madenci AL, Wanis KN, Comment LA, Lotto CE, Shah SK, Ozaki CK, Subramanian SV, Eldrup-Jorgensen J, Belkin M. Association and Interplay of Surgeon and Hospital Volume with Mortality Following Open Abdominal Aortic Aneurysm Repair in the Modern Era. J Vasc Surg. 2020 Sep 22. PMID: 32976969.
    Citations:    Fields:    
  2. Ruske J, Sharma G, Makie K, He K, Ozaki CK, Menard MT, Belkin M, Shah SK. Patient comprehension necessary for informed consent for vascular procedures is poor and related to frailty. J Vasc Surg. 2020 Aug 21. PMID: 32835789.
    Citations:    Fields:    
  3. Trocha KM, Kip P, Tao M, MacArthur MR, Treviño-Villarreal JH, Longchamp A, Toussaint W, Lambrecht BN, de Vries MR, Quax PHA, Mitchell JR, Ozaki CK. Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine ?-lyase. Cardiovasc Res. 2020 02 01; 116(2):416-428. PMID: 30924866.
    Citations: 1     Fields:    Translation:Animals
  4. Lotto CE, Sharma G, Walsh JP, Shah SK, Nguyen LL, Ozaki CK, Menard MT, Belkin M. The impact of combined iliac occlusive disease and aortic aneurysm on open surgical repair. J Vasc Surg. 2020 06; 71(6):2021-2028.e1. PMID: 31727458.
    Citations:    Fields:    
  5. Levitsky LT, Ruske J, Hentschel DM, Nguyen LL, Ozaki CK, Shah SK. Saturday multidisciplinary hemodialysis access clinics to enhance patient care. J Vasc Access. 2020 Jul; 21(4):456-459. PMID: 31680607.
    Citations:    Fields:    Translation:Humans
  6. Blackwood SL, O'Leary JJ, Scully RE, Lotto CE, Nguyen LL, Gravereaux EC, Menard MT, Ozaki CK, Gates JD, Belkin M. Emergency intraoperative vascular surgery consultations at a tertiary academic center. J Vasc Surg. 2020 03; 71(3):967-978. PMID: 31515177.
    Citations:    Fields:    Translation:HumansPHPublic Health
  7. Kip P, Trocha KM, Tao M, O'leary JJ, Ruske J, Giulietti JM, Trevino-Villareal JH, MacArthur MR, Bolze A, Burak MF, Patterson S, Ho KJ, Carmody RN, Guzman RJ, Mitchell JR, Ozaki CK. Insights From a Short-Term Protein-Calorie Restriction Exploratory Trial in Elective Carotid Endarterectomy Patients. Vasc Endovascular Surg. 2019 Aug; 53(6):470-476. PMID: 31216949.
    Citations:    Fields:    Translation:HumansCells
  8. Ozaki CK, Perler BA, Mitchell ME, Gahtan V. The role of the Vascular Surgery Board in surgical education. Semin Vasc Surg. 2019 Mar - Jun; 32(1-2):5-10. PMID: 31540658.
    Citations:    Fields:    Translation:Humans
  9. McGlynn PK, Arnaoutakis KD, Deroo EP, Ozaki CK, Forman JP, Hentschel DM. Postanesthesia ultrasound facilitates creation of more preferred accesses without affecting access survival. J Vasc Surg. 2019 03; 69(3):898-905. PMID: 30798845.
    Citations:    Fields:    Translation:Humans
  10. Bleyer AJ, Scavo VA, Wilson SE, Browne BJ, Ferris BL, Ozaki CK, Lee T, Peden EK, Dixon BS, Mishler R, O'Connor TP, Kidd K, Burke SK. A randomized trial of vonapanitase (PATENCY-1) to promote radiocephalic fistula patency and use for hemodialysis. J Vasc Surg. 2019 02; 69(2):507-515. PMID: 30683197.
    Citations: 4     Fields:    Translation:Humans
  11. Ozaki CK. Invited commentary. J Vasc Surg. 2018 12; 68(6S):220S-221S. PMID: 30470356.
    Citations:    Fields:    Translation:AnimalsCells
  12. Trocha K, Kip P, MacArthur MR, Mitchell SJ, Longchamp A, Treviño-Villarreal JH, Tao M, Bredella MA, De Amorim Bernstein K, Mitchell JR, Ozaki CK. Preoperative Protein or Methionine Restriction Preserves Wound Healing and Reduces Hyperglycemia. J Surg Res. 2019 03; 235:216-222. PMID: 30691797.
    Citations: 1     Fields:    Translation:Animals
  13. Treviño-Villarreal JH, Reynolds JS, Bartelt A, Langston PK, MacArthur MR, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace LE, Mejia P, Trocha K, Kajitani GS, Longchamp A, Harputlugil E, Gathungu R, Bird SS, Bullock AD, Figenshau RS, Andriole GL, Thompson A, Heeren J, Ozaki CK, Kristal BS, Fontana L, Mitchell JR. Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms. JCI Insight. 2018 11 02; 3(21). PMID: 30385734.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  14. de Vries MR, Parma L, Peters HAB, Schepers A, Hamming JF, Jukema JW, Goumans MJTH, Guo L, Finn AV, Virmani R, Ozaki CK, Quax PHA. Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels. J Intern Med. 2019 01; 285(1):59-74. PMID: 30102798.
    Citations: 7     Fields:    Translation:HumansAnimals
  15. Leak RK, Calabrese EJ, Kozumbo WJ, Gidday JM, Johnson TE, Mitchell JR, Ozaki CK, Wetzker R, Bast A, Belz RG, Bøtker HE, Koch S, Mattson MP, Simon RP, Jirtle RL, Andersen ME. Enhancing and Extending Biological Performance and Resilience. Dose Response. 2018 Jul-Sep; 16(3):1559325818784501. PMID: 30140178.
    Citations: 3     
  16. Sharma G, Scully RE, Shah SK, Madenci AL, Arnaoutakis DJ, Menard MT, Ozaki CK, Belkin M. Thirty-year trends in aortofemoral bypass for aortoiliac occlusive disease. J Vasc Surg. 2018 12; 68(6):1796-1804.e2. PMID: 30001912.
    Citations: 1     Fields:    Translation:Humans
  17. Arnaoutakis DJ, Sharma G, Blackwood S, Shah SK, Menard M, Ozaki CK, Belkin M. Strategies and outcomes for aortic endograft explantation. J Vasc Surg. 2019 01; 69(1):80-85. PMID: 29914836.
    Citations: 1     Fields:    Translation:Humans
  18. Greco Song HH, Rumma RT, Ozaki CK, Edelman ER, Chen CS. Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise. Cell Stem Cell. 2018 04 05; 22(4):608. PMID: 29625073.
    Citations: 3     Fields:    
  19. Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 2018 03 22; 173(1):117-129.e14. PMID: 29570992.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  20. Sharma G, Kuppler C, He Y, Tao M, Ding K, Longchamp A, Dember LM, Ozaki CK, Berceli SA. Local Adipose-Associated Mediators and Adaptations Following Arteriovenous Fistula Creation. Kidney Int Rep. 2018 Jul; 3(4):970-978. PMID: 29988980.
    Citations:    
  21. Song HG, Rumma RT, Ozaki CK, Edelman ER, Chen CS. Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise. Cell Stem Cell. 2018 03 01; 22(3):340-354. PMID: 29499152.
    Citations: 18     Fields:    Translation:HumansCells
  22. Mitsouras D, Tao M, de Vries MR, Trocha K, Miranda OR, Vemula PK, Ding K, Imanzadeh A, Schoen FJ, Karp JM, Ozaki CK, Rybicki FJ. Early animal model evaluation of an implantable contrast agent to enhance magnetic resonance imaging of arterial bypass vein grafts. Acta Radiol. 2018 Sep; 59(9):1074-1081. PMID: 29378421.
    Citations:    Fields:    Translation:Animals
  23. Cason CA, Dolan KT, Sharma G, Tao M, Kulkarni R, Helenowski IB, Doane BM, Avram MJ, McDermott MM, Chang EB, Ozaki CK, Ho KJ. Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes. J Vasc Surg. 2018 11; 68(5):1552-1562.e7. PMID: 29248242.
    Citations: 6     Fields:    Translation:HumansCells
  24. Libby P, Sukhova GK, Ozaki CK, Shi GP. Tilting at the tilted protease balance in arterial aneurysmal disease. Cardiovasc Res. 2017 09 01; 113(11):1279-1281. PMID: 28859304.
    Citations:    Fields:    Translation:HumansCells
  25. Arnaoutakis DJ, Deroo EP, McGlynn P, Coll MD, Belkin M, Hentschel DM, Ozaki CK. Improved outcomes with proximal radial-cephalic arteriovenous fistulas compared with brachial-cephalic arteriovenous fistulas. J Vasc Surg. 2017 11; 66(5):1497-1503. PMID: 28760582.
    Citations: 1     Fields:    Translation:Humans
  26. Mirabella T, MacArthur JW, Cheng D, Ozaki CK, Woo YJ, Yang M, Chen CS. 3D-printed vascular networks direct therapeutic angiogenesis in ischaemia. Nat Biomed Eng. 2017; 1. PMID: 29515935.
    Citations: 18     Fields:    
  27. Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. PMID: 28591635.
    Citations: 9     Fields:    Translation:Animals
  28. Arnaoutakis DJ, Scully RE, Sharma G, Shah SK, Ozaki CK, Belkin M, Nguyen LL. Impact of body mass index and gender on wound complications after lower extremity arterial surgery. J Vasc Surg. 2017 06; 65(6):1713-1718.e1. PMID: 28259578.
    Citations: 5     Fields:    Translation:Humans
  29. Longchamp A, Harputlugil E, Corpataux JM, Ozaki CK, Mitchell JR. Is Overnight Fasting before Surgery Too Much or Not Enough? How Basic Aging Research Can Guide Preoperative Nutritional Recommendations to Improve Surgical Outcomes: A Mini-Review. Gerontology. 2017; 63(3):228-237. PMID: 28052287.
    Citations: 2     Fields:    Translation:HumansAnimals
  30. Ozaki CK. Invited commentary. J Vasc Surg. 2017 01; 65(1):206. PMID: 28010860.
    Citations:    Fields:    Translation:Humans
  31. Sharma G, Wong D, Arnaoutakis DJ, Shah SK, O'Brien A, Ashley SW, Ozaki CK. Systematic identification and management of barriers to vascular surgery patient discharge time of day. J Vasc Surg. 2017 Jan; 65(1):172-178. PMID: 27658897.
    Citations: 1     Fields:    Translation:Humans
  32. McGillicuddy EA, Ozaki CK, Shah SK, Belkin M, Hamdan A, Barshes N, Wyers M, Nguyen L. The impact of vascular surgery wound complications on quality of life. J Vasc Surg. 2016 Dec; 64(6):1780-1788. PMID: 27473777.
    Citations:    Fields:    Translation:Humans
  33. Sharma G, Kulkarni R, Shah SK, King WW, Longchamp A, Tao M, Ding K, Ozaki CK. Local perivascular adiponectin associates with lower extremity vascular operative wound complications. Surgery. 2016 07; 160(1):204-210. PMID: 27085683.
    Citations: 1     Fields:    Translation:Humans
  34. Madenci AL, Ozaki CK, Gupta N, Raffetto JD, Belkin M, McPhee JT. Perioperative outcomes of elective inflow revascularization for lower extremity claudication in the American College of Surgeons National Surgical Quality Improvement Program database. Am J Surg. 2016 Sep; 212(3):461-467.e2. PMID: 26792271.
    Citations:    Fields:    Translation:Humans
  35. Longchamp A, Tao M, Bartelt A, Ding K, Lynch L, Hine C, Corpataux JM, Kristal BS, Mitchell JR, Ozaki CK. Surgical injury induces local and distant adipose tissue browning. Adipocyte. 2016 Apr-Jun; 5(2):163-74. PMID: 27386152.
    Citations: 4     Fields:    
  36. Koga JI, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M. Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure. Arterioscler Thromb Vasc Biol. 2015 Nov; 35(11):2343-2353. PMID: 26404485.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  37. Longchamp A, Allagnat F, Alonso F, Kuppler C, Dubuis C, Ozaki CK, Mitchell JR, Berceli S, Corpataux JM, Déglise S, Haefliger JA. Connexin43 Inhibition Prevents Human Vein Grafts Intimal Hyperplasia. PLoS One. 2015; 10(9):e0138847. PMID: 26398895.
    Citations: 1     Fields:    Translation:HumansAnimals
  38. Robertson LT, Treviño-Villarreal JH, Mejia P, Grondin Y, Harputlugil E, Hine C, Vargas D, Zheng H, Ozaki CK, Kristal BS, Simpson SJ, Mitchell JR. Protein and Calorie Restriction Contribute Additively to Protection from Renal Ischemia Reperfusion Injury Partly via Leptin Reduction in Male Mice. J Nutr. 2015 Aug; 145(8):1717-27. PMID: 26041674.
    Citations: 21     Fields:    Translation:Animals
  39. Sharma G, Tao M, Ding K, Yu D, King W, Deyneko G, Wang X, Longchamp A, Schoen FJ, Ozaki CK, Semel ME. Perivascular adipose adiponectin correlates with symptom status of patients undergoing carotid endarterectomy. Stroke. 2015 Jun; 46(6):1696-9. PMID: 25967575.
    Citations: 2     Fields:    Translation:Humans
  40. Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR. Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell. 2015 Jan 15; 160(1-2):132-44. PMID: 25542313.
    Citations: 112     Fields:    Translation:AnimalsCells
  41. Mauro CR, Ding K, Xue H, Tao M, Longchamp A, Belkin M, Kristal BS, Ozaki CK. Adipose phenotype predicts early human autogenous arteriovenous hemodialysis remodeling. J Vasc Surg. 2016 Jan; 63(1):171-6.e1. PMID: 25264363.
    Citations: 5     Fields:    Translation:Humans
  42. Ozaki CK, Hamdan AD, Barshes NR, Wyers M, Hevelone ND, Belkin M, Nguyen LL. Prospective, randomized, multi-institutional clinical trial of a silver alginate dressing to reduce lower extremity vascular surgery wound complications. J Vasc Surg. 2015 Feb; 61(2):419-427.e1. PMID: 25175629.
    Citations: 2     Fields:    Translation:Humans
  43. Taqueti VR, Di Carli MF, Jerosch-Herold M, Sukhova GK, Murthy VL, Folco EJ, Kwong RY, Ozaki CK, Belkin M, Nahrendorf M, Weissleder R, Libby P. Increased microvascularization and vessel permeability associate with active inflammation in human atheromata. Circ Cardiovasc Imaging. 2014 Nov; 7(6):920-9. PMID: 25170063.
    Citations: 16     Fields:    Translation:HumansCells
  44. Mauro CR, Tao M, Yu P, Treviño-Villerreal JH, Longchamp A, Kristal BS, Ozaki CK, Mitchell JR. Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury. J Vasc Surg. 2016 Feb; 63(2):500-9.e1. PMID: 25124359.
    Citations: 13     Fields:    Translation:Animals
  45. Ozaki C, Somamoto S, Kawabata S, Tabata Y. Effect of an artificial silk elastin-like protein on the migration and collagen production of mouse fibroblasts. J Biomater Sci Polym Ed. 2014; 25(12):1266-77. PMID: 24941248.
    Citations: 2     Fields:    Translation:AnimalsCells
  46. Ho KJ, Madenci AL, Semel ME, McPhee JT, Nguyen LL, Ozaki CK, Belkin M. Predictors and consequences of unplanned hospital readmission within 30 days of carotid endarterectomy. J Vasc Surg. 2014 Jul; 60(1):77-84. PMID: 24657298.
    Citations: 4     Fields:    Translation:Humans
  47. Barshes NR, Kougias P, Ozaki CK, Goodney PP, Belkin M. Cost-effectiveness of revascularization for limb preservation in patients with end-stage renal disease. J Vasc Surg. 2014 Aug; 60(2):369-374.e1. PMID: 24657067.
    Citations: 2     Fields:    Translation:Humans
  48. Ozaki CK, Sobieszczyk PS, Ho KJ, McPhee JT, Gravereaux EC. Evidence-based carotid artery-based interventions for stroke risk reduction. Curr Probl Surg. 2014 May; 51(5):198-242. PMID: 24767101.
    Citations:    Fields:    Translation:Humans
  49. Kalwa H, Sartoretto JL, Martinelli R, Romero N, Steinhorn BS, Tao M, Ozaki CK, Carman CV, Michel T. Central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium. Proc Natl Acad Sci U S A. 2014 Mar 04; 111(9):3383-8. PMID: 24550450.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  50. Ozaki CK. In brief. Curr Probl Surg. 2014 May; 51(5):194-6. PMID: 24767100.
    Citations:    
  51. Ho KJ, Madenci AL, McPhee JT, Semel ME, Bafford RA, Nguyen LL, Ozaki CK, Belkin M. Contemporary predictors of extended postoperative hospital length of stay after carotid endarterectomy. J Vasc Surg. 2014 May; 59(5):1282-90. PMID: 24447544.
    Citations: 4     Fields:    Translation:Humans
  52. Barshes NR, Kougias P, Ozaki CK, Pisimisis G, Bechara CF, Henson HK, Belkin M. Cost-effectiveness of revascularization for limb preservation in patients with marginal functional status. Ann Vasc Surg. 2014 Jan; 28(1):10-7. PMID: 24332257.
    Citations: 2     Fields:    Translation:Humans
  53. Favreau JT, Liu C, Yu P, Tao M, Mauro C, Gaudette GR, Ozaki CK. Acute reductions in mechanical wall strain precede the formation of intimal hyperplasia in a murine model of arterial occlusive disease. J Vasc Surg. 2014 Nov; 60(5):1340-1347. PMID: 24139980.
    Citations: 4     Fields:    Translation:Animals
  54. Yu P, Nguyen BT, Tao M, Jiang T, Ozaki CK. Diet-induced obesity drives negative mouse vein graft wall remodeling. J Vasc Surg. 2014 Jun; 59(6):1670-6. PMID: 23876511.
    Citations: 2     Fields:    Translation:Animals
  55. Mauro CR, Nguyen BT, Yu P, Tao M, Gao I, Seidman MA, Nguyen LL, Ozaki CK. Inflammatory "adiposopathy" in major amputation patients. Ann Vasc Surg. 2013 Apr; 27(3):346-52. PMID: 23498310.
    Citations: 7     Fields:    Translation:Humans
  56. McPhee JT, Nguyen LL, Ho KJ, Ozaki CK, Conte MS, Belkin M. Risk prediction of 30-day readmission after infrainguinal bypass for critical limb ischemia. J Vasc Surg. 2013 Jun; 57(6):1481-8. PMID: 23395204.
    Citations: 22     Fields:    Translation:Humans
  57. Barshes NR, Ozaki CK, Kougias P, Belkin M. A cost-effectiveness analysis of infrainguinal bypass in the absence of great saphenous vein conduit. J Vasc Surg. 2013 Jun; 57(6):1466-70. PMID: 23395205.
    Citations: 4     Fields:    Translation:Humans
  58. Madenci AL, Ozaki CK, Belkin M, McPhee JT. Carotid-subclavian bypass and subclavian-carotid transposition in the thoracic endovascular aortic repair era. J Vasc Surg. 2013 May; 57(5):1275-1282.e2. PMID: 23384492.
    Citations: 7     Fields:    Translation:Humans
  59. Kraiss LW, Conte MS, Geary RL, Kibbe M, Ozaki CK. Setting high-impact clinical research priorities for the Society for Vascular Surgery. J Vasc Surg. 2013 Feb; 57(2):493-500. PMID: 23337859.
    Citations: 5     Fields:    Translation:Humans
  60. Clària J, Nguyen BT, Madenci AL, Ozaki CK, Serhan CN. Diversity of lipid mediators in human adipose tissue depots. . 2013 Jun 15; 304(12):C1141-9. PMID: 23364264.
    Citations: 37     Translation:Humans
  61. Mauro CR, Ilonzo G, Nguyen BT, Yu P, Tao M, Gao I, Seidman MA, Nguyen LL, Ozaki CK. Attenuated adiposopathy in perivascular adipose tissue compared with subcutaneous human adipose tissue. Am J Surg. 2013 Aug; 206(2):241-4. PMID: 23352378.
    Citations: 8     Fields:    Translation:Humans
  62. McPhee JT, Barshes NR, Ho KJ, Madenci A, Ozaki CK, Nguyen LL, Belkin M. Predictive factors of 30-day unplanned readmission after lower extremity bypass. J Vasc Surg. 2013 Apr; 57(4):955-62. PMID: 23332242.
    Citations: 13     Fields:    Translation:Humans
  63. Nguyen B, Tao M, Yu P, Mauro C, Seidman MA, Wang YE, Mitchell J, Ozaki CK. Preoperative diet impacts the adipose tissue response to surgical trauma. Surgery. 2013 Apr; 153(4):584-93. PMID: 23274098.
    Citations: 6     Fields:    Translation:Animals
  64. Tao M, Yu P, Nguyen BT, Mizrahi B, Savion N, Kolodgie FD, Virmani R, Hao S, Ozaki CK, Schneiderman J. Locally applied leptin induces regional aortic wall degeneration preceding aneurysm formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):311-20. PMID: 23220275.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  65. Mitchell JR, Beckman JA, Nguyen LL, Ozaki CK. Reducing elective vascular surgery perioperative risk with brief preoperative dietary restriction. Surgery. 2013 Apr; 153(4):594-8. PMID: 23218877.
    Citations: 14     Fields:    Translation:HumansAnimals
  66. Tao M, Mauro CR, Yu P, Favreau JT, Nguyen B, Gaudette GR, Ozaki CK. A simplified murine intimal hyperplasia model founded on a focal carotid stenosis. Am J Pathol. 2013 Jan; 182(1):277-87. PMID: 23159527.
    Citations: 9     Fields:    Translation:Animals
  67. Nguyen BT, Yu P, Tao M, Hao S, Jiang T, Ozaki CK. Perivascular innate immune events modulate early murine vein graft adaptations. J Vasc Surg. 2013 Feb; 57(2):486-492.e2. PMID: 23127978.
    Citations: 4     Fields:    Translation:Animals
  68. Ho KJ, Xue H, Mauro CR, Nguyen B, Yu P, Tao M, Seidman MA, Brunelli SM, Ozaki CK. Impact of uremia on human adipose tissue phenotype. J Surg Res. 2013 Jan; 179(1):175-82. PMID: 23058473.
    Citations: 7     Fields:    Translation:Humans
  69. Yu P, Nguyen BT, Tao M, Jiang T, Mauro CR, Wang Y, Ozaki CK. Lack of interleukin-1 signaling results in perturbed early vein graft wall adaptations. Surgery. 2013 Jan; 153(1):63-9. PMID: 22853857.
    Citations: 3     Fields:    Translation:Animals
  70. Favreau JT, Nguyen BT, Gao I, Yu P, Tao M, Schneiderman J, Gaudette GR, Ozaki CK. Murine ultrasound imaging for circumferential strain analyses in the angiotensin II abdominal aortic aneurysm model. J Vasc Surg. 2012 Aug; 56(2):462-9. PMID: 22503226.
    Citations: 14     Fields:    Translation:Animals
  71. McPhee JT, Barshes NR, Ozaki CK, Nguyen LL, Belkin M. Optimal conduit choice in the absence of single-segment great saphenous vein for below-knee popliteal bypass. J Vasc Surg. 2012 Apr; 55(4):1008-14. PMID: 22365176.
    Citations: 4     Fields:    Translation:Humans
  72. Barshes NR, McPhee J, Ozaki CK, Nguyen LL, Menard MT, Gravereaux E, Belkin M. Increasing complexity in the open surgical repair of abdominal aortic aneurysms. Ann Vasc Surg. 2012 Jan; 26(1):10-7. PMID: 22176874.
    Citations: 3     Fields:    Translation:Humans
  73. Yu P, Nguyen BT, Tao M, Bai Y, Ozaki CK. Mouse vein graft hemodynamic manipulations to enhance experimental utility. Am J Pathol. 2011 Jun; 178(6):2910-9. PMID: 21641408.
    Citations: 9     Fields:    Translation:Animals
  74. Barshes NR, Menard MT, Nguyen LL, Bafford R, Ozaki CK, Belkin M. Infrainguinal bypass is associated with lower perioperative mortality than major amputation in high-risk surgical candidates. J Vasc Surg. 2011 May; 53(5):1251-1259.e1. PMID: 21292432.
    Citations: 4     Fields:    Translation:Humans
  75. Mitsouras D, Vemula PK, Yu P, Tao M, Nguyen BT, Campagna CM, Karp JM, Mulkern RV, Ozaki CK, Rybicki FJ. Immobilized contrast-enhanced MRI: Gadolinium-based long-term MR contrast enhancement of the vein graft vessel wall. Magn Reson Med. 2011 Jan; 65(1):176-83. PMID: 20859994.
    Citations: 1     Fields:    Translation:Humans
  76. Barakat O, Rodriguez GC, Raijman I, Allison PM, Nieto J, Ozaki CF, Wood RP, Engler DA. Clinical value of plasma hepatocyte growth factor measurement for the diagnosis of periampullary cancer and prognosis after pancreaticoduodenectomy. J Surg Oncol. 2010 Dec 01; 102(7):816-20. PMID: 20812348.
    Citations: 2     Fields:    Translation:Humans
  77. Nguyen BT, Vemula PK, Mitsouras D, Yu P, Tao M, Campagna C, Mulkern RV, Rybicki FJ, Karp JM, Ozaki CK. Immobilization of iron oxide magnetic nanoparticles for enhancement of vessel wall magnetic resonance imaging--an ex vivo feasibility study. Bioconjug Chem. 2010 Aug 18; 21(8):1408-12. PMID: 20608720.
    Citations: 2     Fields:    Translation:HumansCells
  78. Yu P, Nguyen BT, Tao M, Campagna C, Ozaki CK. Rationale and practical techniques for mouse models of early vein graft adaptations. J Vasc Surg. 2010 Aug; 52(2):444-52. PMID: 20573477.
    Citations: 14     Fields:    Translation:Animals
  79. Barakat O, Wood RP, Ozaki CF, Ankoma-Sey V, Galati J, Skolkin M, Toombs B, Round M, Moore W, Mieles L. Morphological features of advanced hepatocellular carcinoma as a predictor of downstaging and liver transplantation: an intention-to-treat analysis. Liver Transpl. 2010 Mar; 16(3):289-99. PMID: 20209588.
    Citations: 21     Fields:    Translation:Humans
  80. Jiang Z, Yu P, Tao M, Ifantides C, Ozaki CK, Berceli SA. Interplay of CCR2 signaling and local shear force determines vein graft neointimal hyperplasia in vivo. FEBS Lett. 2009 Nov 03; 583(21):3536-40. PMID: 19822149.
    Citations: 12     Fields:    Translation:AnimalsCells
  81. Jiang Z, Tao M, Omalley KA, Wang D, Ozaki CK, Berceli SA. Established neointimal hyperplasia in vein grafts expands via TGF-beta-mediated progressive fibrosis. . 2009 Oct; 297(4):H1200-7. PMID: 19617405.
    Citations: 25     Translation:AnimalsCells
  82. Stasik CN, Berceli SA, Nelson PR, Lee WA, Ozaki CK. Functional outcome after redo below-knee amputation. World J Surg. 2008 Aug; 32(8):1823-6. PMID: 18311498.
    Citations:    Fields:    Translation:Humans
  83. Zacharski LR, Chow BK, Howes PS, Shamayeva G, Baron JA, Dalman RL, Malenka DJ, Ozaki CK, Lavori PW. Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial. J Natl Cancer Inst. 2008 Jul 16; 100(14):996-1002. PMID: 18612130.
    Citations: 62     Fields:    Translation:Humans
  84. Tran-Son-Tay R, Hwang M, Garbey M, Jiang Z, Ozaki CK, Berceli SA. An experiment-based model of vein graft remodeling induced by shear stress. Ann Biomed Eng. 2008 Jul; 36(7):1083-91. PMID: 18415018.
    Citations: 14     Fields:    Translation:AnimalsCells
  85. Ozaki CK, Jiang Z, Berceli SA. TNF-alpha and shear stress-induced large artery adaptations. J Surg Res. 2007 Aug; 141(2):299-305. PMID: 17574273.
    Citations:    Fields:    Translation:Animals
  86. Ozaki CK. Cytokines and the early vein graft: strategies to enhance durability. J Vasc Surg. 2007 Jun; 45 Suppl A:A92-8. PMID: 17544029.
    Citations: 12     Fields:    Translation:HumansAnimals
  87. Childress BB, Berceli SA, Nelson PR, Lee WA, Ozaki CK. Impact of an absorbent silver-eluting dressing system on lower extremity revascularization wound complications. Ann Vasc Surg. 2007 Sep; 21(5):598-602. PMID: 17521872.
    Citations: 7     Fields:    Translation:Humans
  88. Jiang Z, Yu P, Tao M, Fernandez C, Ifantides C, Moloye O, Schultz GS, Ozaki CK, Berceli SA. TGF-beta- and CTGF-mediated fibroblast recruitment influences early outward vein graft remodeling. . 2007 Jul; 293(1):H482-8. PMID: 17369455.
    Citations: 25     Translation:AnimalsCells
  89. Zacharski LR, Chow BK, Howes PS, Shamayeva G, Baron JA, Dalman RL, Malenka DJ, Ozaki CK, Lavori PW. Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial. JAMA. 2007 Feb 14; 297(6):603-10. PMID: 17299195.
    Citations: 43     Fields:    Translation:Humans
  90. Jiang Z, Shukla A, Miller BL, Espino DR, Tao M, Berceli SA, Ozaki CK. Tumor necrosis factor-alpha and the early vein graft. J Vasc Surg. 2007 Jan; 45(1):169-76. PMID: 17210403.
    Citations: 6     Fields:    Translation:AnimalsCells
  91. Tran-Son-Tay R, Hwang M, Berceli SA, Ozaki CK, Garbey M. A model of vein graft intimal hyperplasia. Annu Int Conf IEEE Eng Med Biol Soc. 2007; 2007:5807-10. PMID: 18003333.
    Citations: 2     Translation:Animals
  92. Ozaki CK. Commentary. Magnetic forces enable rapid endothelialization of synthetic vascular grafts. Perspect Vasc Surg Endovasc Ther. 2006 Dec; 18(4):346-7. PMID: 17396362.
    Citations:    Fields:    
  93. Berceli SA, Brown JE, Irwin PB, Ozaki CK. Clinical outcomes after closed, staged, and open forefoot amputations. J Vasc Surg. 2006 Aug; 44(2):347-351; discussion 352. PMID: 16890866.
    Citations: 3     Fields:    Translation:Humans
  94. Berceli SA, Jiang Z, Klingman NV, Schultz GS, Ozaki CK. Early differential MMP-2 and -9 dynamics during flow-induced arterial and vein graft adaptations. J Surg Res. 2006 Aug; 134(2):327-34. PMID: 16488440.
    Citations: 10     Fields:    Translation:AnimalsCells
  95. Grundmann S, Hoefer I, Ulusans S, van Royen N, Schirmer SH, Ozaki CK, Bode C, Piek JJ, Buschmann I. Anti-tumor necrosis factor-{alpha} therapies attenuate adaptive arteriogenesis in the rabbit. . 2005 Oct; 289(4):H1497-505. PMID: 15923311.
    Citations: 13     Translation:AnimalsCells
  96. Fernandez CM, Goldman DR, Jiang Z, Ozaki CK, Tran-Son-Tay R, Berceli SA. Impact of shear stress on early vein graft remodeling: a biomechanical analysis. Ann Biomed Eng. 2004 Nov; 32(11):1484-93. PMID: 15636109.
    Citations: 11     Fields:    Translation:Animals
  97. Perrault CM, Bray EJ, Didier N, Ozaki CK, Tran-Son-Tay R. Altered rheology of lymphocytes in the diabetic mouse. Diabetologia. 2004 Oct; 47(10):1722-6. PMID: 15517153.
    Citations: 3     Fields:    Translation:AnimalsCells
  98. Jiang Z, Berceli SA, Pfahnl CL, Wu L, Goldman D, Tao M, Kagayama M, Matsukawa A, Ozaki CK. Wall shear modulation of cytokines in early vein grafts. J Vasc Surg. 2004 Aug; 40(2):345-50. PMID: 15297832.
    Citations: 20     Fields:    Translation:Animals
  99. Jiang Z, Berceli SA, Pfahnl CL, Wu L, Killingsworth CD, Vieira FG, Ozaki CK. Impact of IL-1beta on flow-induced outward arterial remodeling. Surgery. 2004 Aug; 136(2):478-82. PMID: 15300218.
    Citations: 3     Fields:    Translation:Animals
  100. Berceli SA, Jiang Z, Klingman NV, Pfahnl CL, Abouhamze ZS, Frase CD, Schultz GS, Ozaki CK. Differential expression and activity of matrix metalloproteinases during flow-modulated vein graft remodeling. J Vasc Surg. 2004 May; 39(5):1084-90. PMID: 15111865.
    Citations: 14     Fields:    Translation:AnimalsCells
  101. Hoefer IE, van Royen N, Rectenwald JE, Deindl E, Hua J, Jost M, Grundmann S, Voskuil M, Ozaki CK, Piek JJ, Buschmann IR. Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms. Circ Res. 2004 May 14; 94(9):1179-85. PMID: 15059933.
    Citations: 46     Fields:    Translation:AnimalsCells
  102. Jiang Z, Wu L, Miller BL, Goldman DR, Fernandez CM, Abouhamze ZS, Ozaki CK, Berceli SA. A novel vein graft model: adaptation to differential flow environments. . 2004 Jan; 286(1):H240-5. PMID: 14500133.
    Citations: 37     Translation:Animals
  103. Lee WA, Berceli SA, Huber TS, Ozaki CK, Flynn TC, Seeger JM. Morbidity with retroperitoneal procedures during endovascular abdominal aortic aneurysm repair. J Vasc Surg. 2003 Sep; 38(3):459-63; discussion 464-5. PMID: 12947255.
    Citations: 4     Fields:    Translation:Humans
  104. Huber TS, Ozaki CK, Flynn TC, Lee WA, Berceli SA, Hirneise CM, Carlton LM, Carter JW, Ross EA, Seeger JM. Prospective validation of an algorithm to maximize native arteriovenous fistulae for chronic hemodialysis access. J Vasc Surg. 2002 Sep; 36(3):452-9. PMID: 12218966.
    Citations: 23     Fields:    Translation:Humans
  105. Jimenez JG, Huber TS, Ozaki CK, Flynn TC, Berceli SA, Lee WA, Seeger JM, Jimenez JG. Durability of antegrade synthetic aortomesenteric bypass for chronic mesenteric ischemia. J Vasc Surg. 2002 Jun; 35(6):1078-84. PMID: 12042717.
    Citations: 7     Fields:    Translation:Humans
  106. Hoefer IE, van Royen N, Rectenwald JE, Bray EJ, Abouhamze Z, Moldawer LL, Voskuil M, Piek JJ, Buschmann IR, Ozaki CK. Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis. Circulation. 2002 Apr 09; 105(14):1639-41. PMID: 11940540.
    Citations: 35     Fields:    Translation:AnimalsCells
  107. Rectenwald JE, Huber TS, Martin TD, Ozaki CK, Devidas M, Welborn MB, Seeger JM. Functional outcome after thoracoabdominal aortic aneurysm repair. J Vasc Surg. 2002 Apr; 35(4):640-7. PMID: 11932656.
    Citations: 10     Fields:    Translation:Humans
  108. Rectenwald JE, Minter RM, Moldawer LL, Abouhamze Z, La Face D, Hutchins E, Huber TS, Seeger JM, Ozaki CK. Interleukin-10 fails to modulate low shear stress-induced neointimal hyperplasia. J Surg Res. 2002 Feb; 102(2):110-8. PMID: 11796006.
    Citations: 6     Fields:    Translation:AnimalsCells
  109. Derrow AE, Seeger JM, Dame DA, Carter RL, Ozaki CK, Flynn TC, Huber TS. The outcome in the United States after thoracoabdominal aortic aneurysm repair, renal artery bypass, and mesenteric revascularization. J Vasc Surg. 2001 Jul; 34(1):54-61. PMID: 11436075.
    Citations: 11     Fields:    Translation:Humans
  110. Rectenwald JE, Pretus HA, Seeger JM, Huber TS, Mendenhall NP, Zlotecki RA, Palta JR, Li ZF, Hook SY, Sarac TP, Welborn MB, Klingman NV, Abouhamze ZS, Ozaki CK. External-beam radiation therapy for improved dialysis access patency: feasibility and early safety. Radiat Res. 2001 Jul; 156(1):53-60. PMID: 11418073.
    Citations:    Fields:    Translation:Animals
  111. Huber TS, Wang JG, Derrow AE, Dame DA, Ozaki CK, Zelenock GB, Flynn TC, Seeger JM. Experience in the United States with intact abdominal aortic aneurysm repair. J Vasc Surg. 2001 Feb; 33(2):304-10; discussion 310-1. PMID: 11174782.
    Citations: 14     Fields:    Translation:Humans
  112. Rectenwald JE, Moldawer LL, Huber TS, Seeger JM, Ozaki CK. Direct evidence for cytokine involvement in neointimal hyperplasia. Circulation. 2000 Oct 03; 102(14):1697-702. PMID: 11015350.
    Citations: 39     Fields:    Translation:Animals
  113. Seeger JM, Pretus HA, Welborn MB, Ozaki CK, Flynn TC, Huber TS. Long-term outcome after treatment of aortic graft infection with staged extra-anatomic bypass grafting and aortic graft removal. J Vasc Surg. 2000 Sep; 32(3):451-9; discussion 460-1. PMID: 10957651.
    Citations: 17     Fields:    Translation:Humans
  114. Huber TS, Ozaki CK, Flynn TC, Ross EA, Seeger JM. Use of superficial femoral vein for hemodialysis arteriovenous access. J Vasc Surg. 2000 May; 31(5):1038-41. PMID: 10805897.
    Citations: 5     Fields:    Translation:Humans
  115. Huber TS, Wang JG, Wheeler KG, Cuddeback JK, Dame DA, Ozaki CK, Flynn TC, Seeger JM. Impact of race on the treatment for peripheral arterial occlusive disease. J Vasc Surg. 1999 Sep; 30(3):417-25. PMID: 10477634.
    Citations: 10     Fields:    Translation:Humans
  116. Seeger JM, Pretus HA, Carlton LC, Flynn TC, Ozaki CK, Huber TS. Potential predictors of outcome in patients with tissue loss who undergo infrainguinal vein bypass grafting. J Vasc Surg. 1999 Sep; 30(3):427-35. PMID: 10477635.
    Citations: 7     Fields:    Translation:Humans
  117. Ozaki CK, Irwin PB, Flynn TC, Huber TS, Seeger JM. Surgical decision making for carotid endarterectomy and contemporary magnetic resonance angiography. Am J Surg. 1999 Sep; 178(3):182-4. PMID: 10527434.
    Citations: 1     Fields:    Translation:Humans
  118. Sarac TP, Huber TS, Back MR, Ozaki CK, Carlton LM, Flynn TC, Seeger JM. Warfarin improves the outcome of infrainguinal vein bypass grafting at high risk for failure. J Vasc Surg. 1998 Sep; 28(3):446-57. PMID: 9737454.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  119. Farrehi PM, Ozaki CK, Carmeliet P, Fay WP. Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice. Circulation. 1998 Mar 17; 97(10):1002-8. PMID: 9529269.
    Citations: 40     Fields:    Translation:HumansAnimals
  120. Shanley CJ, Ozaki CK, Zelenock GB. Bypass grafting for chronic mesenteric ischemia. Surg Clin North Am. 1997 Apr; 77(2):381-95. PMID: 9146720.
    Citations: 4     Fields:    Translation:Humans
  121. Ozaki CK, Contreras M, Phaneuf M, Sheppeck RA, Rutter CM, Quist WC, LoGerfo FW. Platelet activation by healing ePTFE grafts. J Biomed Mater Res. 1995 May; 29(5):647-53. PMID: 7622550.
    Citations: 2     Fields:    Translation:AnimalsCells
  122. Hamdan AD, Aiello LP, Quist WC, Ozaki CK, Contreras MA, Phaneuf MD, Ruiz C, King GL, LoGerfo FW. Isolation of genes differentially expressed at the downstream anastomosis of prosthetic arterial grafts with use of mRNA differential display. J Vasc Surg. 1995 Feb; 21(2):228-34. PMID: 7853596.
    Citations: 2     Fields:    Translation:AnimalsCells
  123. Ozaki CF, Katz SM, Monsour HP, Dyer CH, Wood RP. Surgical complications of liver transplantation. Surg Clin North Am. 1994 Oct; 74(5):1155-67. PMID: 7940066.
    Citations: 3     Fields:    Translation:Humans
  124. Phaneuf MD, Ozaki CK, Johnstone MT, Loza JP, Quist WC, LoGerfo FW. Covalent linkage of streptokinase to recombinant hirudin: a novel thrombolytic agent with antithrombotic properties. Thromb Haemost. 1994 Apr; 71(4):481-7. PMID: 8052967.
    Citations: 1     Fields:    Translation:HumansCells
  125. Ozaki CK, Phaneuf MD, Bide MJ, Quist WC, Alessi JM, LoGerfo FW. In vivo testing of an infection-resistant vascular graft material. J Surg Res. 1993 Nov; 55(5):543-7. PMID: 8231173.
    Citations: 1     Fields:    Translation:AnimalsCells
  126. Ozaki CK, Phaneuf MD, Hong SL, Quist WC, LoGerfo FW. Glycoconjugate mediated endothelial cell adhesion to Dacron polyester film. J Vasc Surg. 1993 Sep; 18(3):486-94. PMID: 8377243.
    Citations: 1     Fields:    Translation:HumansCells
  127. Phaneuf MD, Ozaki CK, Bide MJ, Quist WC, Alessi JM, Tannenbaum GA, LoGerfo FW. Application of the quinolone antibiotic ciprofloxacin to Dacron utilizing textile dyeing technology. J Biomed Mater Res. 1993 Feb; 27(2):233-7. PMID: 8436580.
    Citations: 2     Fields:    Translation:Cells
  128. Ozaki CK, Chu SH, Walker WA. Developmental changes in galactosyltransferase activity in the rat small intestine. Biochim Biophys Acta. 1989 May 31; 991(2):243-7. PMID: 2497785.
    Citations: 5     Fields:    Translation:Animals
  129. Ozaki CK, Hansen M, Kadir S. Transhepatic embolization of superior mesenteric varices in portal hypertension. Surgery. 1989 Mar; 105(3):446-8. PMID: 2922679.
    Citations: 5     Fields:    Translation:Humans
  130. Ozaki CF, Anderson JC, Lieberman RP, Rikkers LF. Duplex ultrasonography as a noninvasive technique for assessing portal hemodynamics. Am J Surg. 1988 Jan; 155(1):70-5. PMID: 3277468.
    Citations: 6     Fields:    Translation:Humans
  131. Neu J, Ozaki CK, Angelides KJ. Glucocorticoid-mediated alteration of fluidity of brush border membrane in rat small intestine. Pediatr Res. 1986 Jan; 20(1):79-82. PMID: 3511441.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.