Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Robert Sackstein, M.D.,Ph.D.

Concepts

This page shows the publications Robert Sackstein has written about Humans.
Connection Strength

0.346
  1. Fucosyltransferase-specific inhibition via next generation of fucose mimetics. Chem Commun (Camb). 2021 Jan 28; 57(9):1145-1148.
    View in: PubMed
    Score: 0.011
  2. sLeX Expression Delineates Distinct Functional Subsets of Human Blood Central and Effector Memory T Cells. J Immunol. 2020 10 01; 205(7):1920-1932.
    View in: PubMed
    Score: 0.010
  3. Glycoengineering of chimeric antigen receptor (CAR) T-cells to enforce E-selectin binding. J Biol Chem. 2019 11 29; 294(48):18465-18474.
    View in: PubMed
    Score: 0.010
  4. The First Step in Adoptive Cell Immunotherapeutics: Assuring Cell Delivery via Glycoengineering. Front Immunol. 2018; 9:3084.
    View in: PubMed
    Score: 0.009
  5. Production via good manufacturing practice of exofucosylated human mesenchymal stromal cells for clinical applications. Cytotherapy. 2018 09; 20(9):1110-1123.
    View in: PubMed
    Score: 0.009
  6. Ligation of the CD44 Glycoform HCELL on Culture-Expanded Human Monocyte-Derived Dendritic Cells Programs Transendothelial Migration. J Immunol. 2018 08 01; 201(3):1030-1043.
    View in: PubMed
    Score: 0.009
  7. Distinct human a(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells. J Biol Chem. 2018 05 11; 293(19):7300-7314.
    View in: PubMed
    Score: 0.009
  8. Imaging specific cellular glycan structures using glycosyltransferases via click chemistry. Glycobiology. 2018 02 01; 28(2):69-79.
    View in: PubMed
    Score: 0.009
  9. T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy. Lab Invest. 2017 06; 97(6):669-697.
    View in: PubMed
    Score: 0.008
  10. Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology. J Immunol. 2017 05 01; 198(9):3576-3587.
    View in: PubMed
    Score: 0.008
  11. A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells. Stem Cells. 2017 04; 35(4):1080-1092.
    View in: PubMed
    Score: 0.008
  12. Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells. Stem Cells. 2016 10; 34(10):2501-2511.
    View in: PubMed
    Score: 0.008
  13. Translational glycobiology: Patient-oriented glycoscience research. Glycobiology. 2016 06; 26(6):544-5.
    View in: PubMed
    Score: 0.008
  14. Fulfilling Koch's postulates in glycoscience: HCELL, GPS and translational glycobiology. Glycobiology. 2016 06; 26(6):560-70.
    View in: PubMed
    Score: 0.008
  15. HCELL Expression on Murine MSC Licenses Pancreatotropism and Confers Durable Reversal of Autoimmune Diabetes in NOD Mice. Stem Cells. 2015 May; 33(5):1523-31.
    View in: PubMed
    Score: 0.007
  16. G-CSF induces membrane expression of a myeloperoxidase glycovariant that operates as an E-selectin ligand on human myeloid cells. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10696-701.
    View in: PubMed
    Score: 0.007
  17. Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect. Hum Mol Genet. 2014 Jun 01; 23(11):2880-7.
    View in: PubMed
    Score: 0.007
  18. Re: "Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2R?(null) mice". Exp Hematol. 2012 Jul; 40(7):518-9; author reply 519-20.
    View in: PubMed
    Score: 0.006
  19. Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution. Ann N Y Acad Sci. 2012 Apr; 1253:193-200.
    View in: PubMed
    Score: 0.006
  20. Glycoengineering of HCELL, the human bone marrow homing receptor: sweetly programming cell migration. Ann Biomed Eng. 2012 Apr; 40(4):766-76.
    View in: PubMed
    Score: 0.006
  21. CD44 and HCELL: preventing hematogenous metastasis at step 1. FEBS Lett. 2011 Oct 20; 585(20):3148-58.
    View in: PubMed
    Score: 0.006
  22. The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives. Curr Opin Hematol. 2011 Jul; 18(4):239-48.
    View in: PubMed
    Score: 0.006
  23. Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells. Blood. 2011 Aug 18; 118(7):1774-83.
    View in: PubMed
    Score: 0.005
  24. Enforced hematopoietic cell E- and L-selectin ligand (HCELL) expression primes transendothelial migration of human mesenchymal stem cells. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2258-63.
    View in: PubMed
    Score: 0.005
  25. Directing stem cell trafficking via GPS. Methods Enzymol. 2010; 479:93-105.
    View in: PubMed
    Score: 0.005
  26. Embryonic stem cell-based therapeutics: balancing scientific progress and bioethics. Health Matrix Clevel. 2010; 20(1):203-17.
    View in: PubMed
    Score: 0.005
  27. Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions. J Leukoc Biol. 2009 Dec; 86(6):1285-94.
    View in: PubMed
    Score: 0.005
  28. Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration. Immunol Rev. 2009 Jul; 230(1):51-74.
    View in: PubMed
    Score: 0.005
  29. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat Chem Biol. 2008 Dec; 4(12):751-7.
    View in: PubMed
    Score: 0.005
  30. L-selectin-mediated lymphocyte-cancer cell interactions under low fluid shear conditions. J Biol Chem. 2008 Jun 06; 283(23):15816-24.
    View in: PubMed
    Score: 0.004
  31. Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med. 2008 Feb; 14(2):181-7.
    View in: PubMed
    Score: 0.004
  32. Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm. Blood. 2007 Feb 15; 109(4):1381-6.
    View in: PubMed
    Score: 0.004
  33. G-CSF induces E-selectin ligand expression on human myeloid cells. Nat Med. 2006 Oct; 12(10):1185-90.
    View in: PubMed
    Score: 0.004
  34. HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells. J Biol Chem. 2006 May 19; 281(20):13899-905.
    View in: PubMed
    Score: 0.004
  35. A revision of Billingham's tenets: the central role of lymphocyte migration in acute graft-versus-host disease. Biol Blood Marrow Transplant. 2006 Jan; 12(1 Suppl 1):2-8.
    View in: PubMed
    Score: 0.004
  36. The blot rolling assay: a method for identifying adhesion molecules mediating binding under shear conditions. Methods Mol Biol. 2006; 341:217-26.
    View in: PubMed
    Score: 0.004
  37. The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr Opin Hematol. 2005 Nov; 12(6):444-50.
    View in: PubMed
    Score: 0.004
  38. CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity. Cancer Res. 2005 Jul 01; 65(13):5812-7.
    View in: PubMed
    Score: 0.004
  39. The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing. J Investig Dermatol Symp Proc. 2004 Sep; 9(3):215-23.
    View in: PubMed
    Score: 0.003
  40. The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing. J Invest Dermatol. 2004 May; 122(5):1061-9.
    View in: PubMed
    Score: 0.003
  41. Primed marrow for autologous and allogeneic transplantation: a review comparing primed marrow to mobilized blood and steady-state marrow. Exp Hematol. 2004 Apr; 32(4):327-39.
    View in: PubMed
    Score: 0.003
  42. CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD. Blood. 2004 Jan 15; 103(2):740-2.
    View in: PubMed
    Score: 0.003
  43. Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin. Blood. 2003 Jan 15; 101(2):602-10.
    View in: PubMed
    Score: 0.003
  44. In vitro adherence of lymphocytes to dermal endothelium under shear stress: implications in pathobiology and steroid therapy of acute cutaneous GVHD. Blood. 2003 Jan 15; 101(2):771-8.
    View in: PubMed
    Score: 0.003
  45. Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots. J Immunol. 2002 Jun 01; 168(11):5645-51.
    View in: PubMed
    Score: 0.003
  46. differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1. J Biol Chem. 2001 Dec 14; 276(50):47623-31.
    View in: PubMed
    Score: 0.003
  47. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. J Cell Biol. 2001 Jun 11; 153(6):1277-86.
    View in: PubMed
    Score: 0.003
  48. Emerging glyco-based strategies to steer immune responses. FEBS J. 2021 08; 288(16):4746-4772.
    View in: PubMed
    Score: 0.003
  49. A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13841-6.
    View in: PubMed
    Score: 0.003
  50. A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity. Blood. 2000 Oct 15; 96(8):2765-74.
    View in: PubMed
    Score: 0.003
  51. The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation. Sci Rep. 2020 08 04; 10(1):13162.
    View in: PubMed
    Score: 0.003
  52. Defibrotide inhibits donor leucocyte-endothelial interactions and protects against acute graft-versus-host disease. J Cell Mol Med. 2020 07; 24(14):8031-8044.
    View in: PubMed
    Score: 0.003
  53. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Nat Cell Biol. 2019 05; 21(5):627-639.
    View in: PubMed
    Score: 0.002
  54. Bone marrow mesenchymal stem/stromal cells from risk-stratified acute myeloid leukemia patients are anti-inflammatory in in vivo preclinical models of hematopoietic reconstitution and severe colitis. Haematologica. 2019 02; 104(2):e54-e58.
    View in: PubMed
    Score: 0.002
  55. Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue. BMC Cancer. 2018 05 02; 18(1):495.
    View in: PubMed
    Score: 0.002
  56. Inhibition of fucosylation in human invasive ductal carcinoma reduces E-selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation. Mol Oncol. 2018 05; 12(5):579-593.
    View in: PubMed
    Score: 0.002
  57. Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression. Sci Rep. 2018 01 11; 8(1):420.
    View in: PubMed
    Score: 0.002
  58. mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors. J Clin Invest. 2017 Jun 01; 127(6):2433-2437.
    View in: PubMed
    Score: 0.002
  59. A hematopoietic cell L-selectin ligand exhibits sulfate-independent binding activity. Blood. 1997 Apr 15; 89(8):2773-81.
    View in: PubMed
    Score: 0.002
  60. Expression of an L-selectin ligand on hematopoietic progenitor cells. Acta Haematol. 1997; 97(1-2):22-8.
    View in: PubMed
    Score: 0.002
  61. Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8.
    View in: PubMed
    Score: 0.002
  62. Lymphocyte migration following bone marrow transplantation. Ann N Y Acad Sci. 1995 Dec 29; 770:177-88.
    View in: PubMed
    Score: 0.002
  63. Physiologic basis of steroid-induced immunosuppression. Effects on lymphocyte migration to lymph nodes. J Fla Med Assoc. 1995 Sep; 82(9):613-5.
    View in: PubMed
    Score: 0.002
  64. Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells. Curr Opin Hematol. 2015 Jul; 22(4):317-23.
    View in: PubMed
    Score: 0.002
  65. The effects of corticosteroids on lymphocyte recirculation in humans: analysis of the mechanism of impaired lymphocyte migration to lymph node following methylprednisolone administration. J Investig Med. 1995 Feb; 43(1):68-77.
    View in: PubMed
    Score: 0.002
  66. Detection of an L-selectin ligand on a hematopoietic progenitor cell line. Blood. 1994 Nov 15; 84(10):3299-306.
    View in: PubMed
    Score: 0.002
  67. Effects of methylprednisolone administration on lymphocyte LECAM-1, CD44, and LFA-1 expression. Implications for steroid-induced lymphopenia. Ann N Y Acad Sci. 1993 Nov 30; 696:417-9.
    View in: PubMed
    Score: 0.002
  68. Physiologic migration of lymphocytes to lymph nodes following bone marrow transplantation: role in immune recovery. Semin Oncol. 1993 Oct; 20(5 Suppl 6):34-9.
    View in: PubMed
    Score: 0.002
  69. CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture. J Tissue Eng Regen Med. 2013 Jul; 7(7):572-83.
    View in: PubMed
    Score: 0.001
  70. Desialylation accelerates platelet clearance after refrigeration and initiates GPIba metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 02; 119(5):1263-73.
    View in: PubMed
    Score: 0.001
  71. Lymphocyte recognition of psoriatic endothelium: evidence for a tissue-specific receptor/ligand interaction. J Invest Dermatol. 1989 Aug; 93(2 Suppl):82S-87S.
    View in: PubMed
    Score: 0.001
  72. Lymphocyte adhesion to psoriatic dermal endothelium is mediated by a tissue-specific receptor/ligand interaction. J Invest Dermatol. 1988 Nov; 91(5):423-8.
    View in: PubMed
    Score: 0.001
  73. Specific lymphocyte-endothelial cell interactions regulate migration into lymph nodes, Peyer's patches, and skin. Reg Immunol. 1988 Jul-Aug; 1(1):78-83.
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    Score: 0.001
  74. SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. Blood. 2008 Jul 01; 112(1):150-8.
    View in: PubMed
    Score: 0.001
  75. Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: implications for posttransplant survival. Exp Hematol. 2008 Apr; 36(4):464-72.
    View in: PubMed
    Score: 0.001
  76. Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells. FASEB J. 2006 Feb; 20(2):337-9.
    View in: PubMed
    Score: 0.001
  77. CD43 is a ligand for E-selectin on CLA+ human T cells. Blood. 2006 Feb 15; 107(4):1421-6.
    View in: PubMed
    Score: 0.001
  78. Molecular biology of the human and mouse MHC class III genes: phylogenetic conservation, genetics and regulation of expression. Immunol Rev. 1985 Oct; 87:185-208.
    View in: PubMed
    Score: 0.001
  79. Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation. Br J Haematol. 2005 Feb; 128(3):351-9.
    View in: PubMed
    Score: 0.001
  80. Molecular regulation of MHC class III (C4 and factor B) gene expression in mouse peritoneal macrophages. J Immunol. 1984 Sep; 133(3):1618-26.
    View in: PubMed
    Score: 0.001
  81. Do G-CSF mobilized, peripheral blood-derived stem cells from healthy, HLA-identical donors really engraft more rapidly than do G-CSF primed, bone marrow-derived stem cells? No! Blood Cells Mol Dis. 2004 Jan-Feb; 32(1):106-11.
    View in: PubMed
    Score: 0.001
  82. Phylogenetic conservation of a class III major histocompatibility complex antigen, factor B. Isolation and nucleotide sequencing of mouse factor B cDNA clones. J Biol Chem. 1983 Dec 10; 258(23):14693-7.
    View in: PubMed
    Score: 0.001
  83. Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation. Exp Hematol. 2003 Jul; 31(7):609-21.
    View in: PubMed
    Score: 0.001
  84. Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants. Biol Blood Marrow Transplant. 2003 Jun; 9(6):373-82.
    View in: PubMed
    Score: 0.001
  85. Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2003 May; 9(5):320-9.
    View in: PubMed
    Score: 0.001
  86. Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical related allogeneic bone marrow transplant. Cytokines Cell Mol Ther. 2002 Dec; 7(2):43-7.
    View in: PubMed
    Score: 0.001
  87. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation. 2002 Nov 27; 74(10):1405-9.
    View in: PubMed
    Score: 0.001
  88. Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells. Transplantation. 2002 Oct 27; 74(8):1159-66.
    View in: PubMed
    Score: 0.001
  89. Porcine mononuclear cells adhere to human fibronectin independently of very late antigen-5: implications for donor-specific tolerance induction in xenotransplantation. Xenotransplantation. 2002 Jul; 9(4):277-89.
    View in: PubMed
    Score: 0.001
  90. A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol. 2001 Nov 15; 167(10):5531-4.
    View in: PubMed
    Score: 0.001
  91. Real-time evidence of in vivo leukocyte trafficking in human skin by reflectance confocal microscopy. J Invest Dermatol. 2001 Aug; 117(2):384-6.
    View in: PubMed
    Score: 0.001
  92. Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation. Biol Blood Marrow Transplant. 2001; 7(11):604-12.
    View in: PubMed
    Score: 0.001
  93. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation. 2000 Nov 15; 70(9):1323-31.
    View in: PubMed
    Score: 0.001
  94. Von willebrand factor concentration, multimeric patterns, and cleaving protease activity in baboons undergoing xenogeneic peripheral blood stem cell transplantation. Transplant Proc. 2000 Aug; 32(5):990.
    View in: PubMed
    Score: 0.001
  95. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation. 2000 Jun 15; 69(11):2296-304.
    View in: PubMed
    Score: 0.001
  96. Cytokine-mobilized peripheral blood progenitor cells for allogeneic reconstitution of miniature swine. Transplantation. 2000 Jan 15; 69(1):135-40.
    View in: PubMed
    Score: 0.001
  97. High-dose cyclophosphamide + carboplatin and interleukin-2 (IL-2) activated autologous stem cell transplantation followed by maintenance IL-2 therapy in metastatic breast carcinoma - a phase II study. Bone Marrow Transplant. 2000 Jan; 25(1):19-24.
    View in: PubMed
    Score: 0.001
  98. Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. Biol Blood Marrow Transplant. 2000; 6(3A):309-20.
    View in: PubMed
    Score: 0.001
  99. The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha. Blood. 1999 Dec 15; 94(12):4233-46.
    View in: PubMed
    Score: 0.001
  100. Late onset veno-occlusive disease following high-dose chemotherapy and stem cell transplantation. Bone Marrow Transplant. 1999 Oct; 24(8):891-5.
    View in: PubMed
    Score: 0.001
  101. A prospective randomized trial comparing the toxicity and safety of atovaquone with trimethoprim/sulfamethoxazole as Pneumocystis carinii pneumonia prophylaxis following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1999 Oct; 24(8):897-902.
    View in: PubMed
    Score: 0.001
  102. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation. 1999 Aug 27; 68(4):480-4.
    View in: PubMed
    Score: 0.001
  103. Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation. Lancet. 1999 May 22; 353(9166):1755-9.
    View in: PubMed
    Score: 0.001
  104. High-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with multiple myeloma and renal insufficiency. Bone Marrow Transplant. 1997 Oct; 20(8):653-6.
    View in: PubMed
    Score: 0.001
  105. Cutaneous CD56+ large T-cell lymphoma associated with high serum concentration of IL-2. Hum Pathol. 1996 Jul; 27(7):738-44.
    View in: PubMed
    Score: 0.000
  106. Lymphocyte-homing receptors and preferential migration pathways. . 1991 Apr; 196(4):374-80.
    View in: PubMed
    Score: 0.000
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.