Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Robert Sackstein, M.D.,Ph.D.

Concepts

This page shows the publications Robert Sackstein has written about Animals.
Connection Strength

0.449
  1. Glycoengineering of chimeric antigen receptor (CAR) T-cells to enforce E-selectin binding. J Biol Chem. 2019 11 29; 294(48):18465-18474.
    View in: PubMed
    Score: 0.021
  2. Ligation of the CD44 Glycoform HCELL on Culture-Expanded Human Monocyte-Derived Dendritic Cells Programs Transendothelial Migration. J Immunol. 2018 08 01; 201(3):1030-1043.
    View in: PubMed
    Score: 0.019
  3. Imaging specific cellular glycan structures using glycosyltransferases via click chemistry. Glycobiology. 2018 02 01; 28(2):69-79.
    View in: PubMed
    Score: 0.019
  4. T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy. Lab Invest. 2017 06; 97(6):669-697.
    View in: PubMed
    Score: 0.018
  5. Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells. Stem Cells. 2016 10; 34(10):2501-2511.
    View in: PubMed
    Score: 0.017
  6. Fulfilling Koch's postulates in glycoscience: HCELL, GPS and translational glycobiology. Glycobiology. 2016 06; 26(6):560-70.
    View in: PubMed
    Score: 0.017
  7. Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple sclerosis. Glycobiology. 2015 Dec; 25(12):1392-409.
    View in: PubMed
    Score: 0.016
  8. HCELL Expression on Murine MSC Licenses Pancreatotropism and Confers Durable Reversal of Autoimmune Diabetes in NOD Mice. Stem Cells. 2015 May; 33(5):1523-31.
    View in: PubMed
    Score: 0.016
  9. Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay. Methods Mol Biol. 2015; 1312:399-410.
    View in: PubMed
    Score: 0.015
  10. G-CSF induces membrane expression of a myeloperoxidase glycovariant that operates as an E-selectin ligand on human myeloid cells. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10696-701.
    View in: PubMed
    Score: 0.015
  11. Re: "Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2R?(null) mice". Exp Hematol. 2012 Jul; 40(7):518-9; author reply 519-20.
    View in: PubMed
    Score: 0.013
  12. Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution. Ann N Y Acad Sci. 2012 Apr; 1253:193-200.
    View in: PubMed
    Score: 0.013
  13. CD44 and HCELL: preventing hematogenous metastasis at step 1. FEBS Lett. 2011 Oct 20; 585(20):3148-58.
    View in: PubMed
    Score: 0.012
  14. The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives. Curr Opin Hematol. 2011 Jul; 18(4):239-48.
    View in: PubMed
    Score: 0.012
  15. Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells. Blood. 2011 Aug 18; 118(7):1774-83.
    View in: PubMed
    Score: 0.012
  16. Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration. Immunol Rev. 2009 Jul; 230(1):51-74.
    View in: PubMed
    Score: 0.010
  17. Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay. Methods Mol Biol. 2009; 536:343-54.
    View in: PubMed
    Score: 0.010
  18. Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med. 2008 Feb; 14(2):181-7.
    View in: PubMed
    Score: 0.009
  19. G-CSF induces E-selectin ligand expression on human myeloid cells. Nat Med. 2006 Oct; 12(10):1185-90.
    View in: PubMed
    Score: 0.009
  20. A revision of Billingham's tenets: the central role of lymphocyte migration in acute graft-versus-host disease. Biol Blood Marrow Transplant. 2006 Jan; 12(1 Suppl 1):2-8.
    View in: PubMed
    Score: 0.008
  21. The blot rolling assay: a method for identifying adhesion molecules mediating binding under shear conditions. Methods Mol Biol. 2006; 341:217-26.
    View in: PubMed
    Score: 0.008
  22. The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr Opin Hematol. 2005 Nov; 12(6):444-50.
    View in: PubMed
    Score: 0.008
  23. The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing. J Investig Dermatol Symp Proc. 2004 Sep; 9(3):215-23.
    View in: PubMed
    Score: 0.007
  24. The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing. J Invest Dermatol. 2004 May; 122(5):1061-9.
    View in: PubMed
    Score: 0.007
  25. Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. J Clin Invest. 2003 Oct; 112(7):1008-18.
    View in: PubMed
    Score: 0.007
  26. Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots. J Immunol. 2002 Jun 01; 168(11):5645-51.
    View in: PubMed
    Score: 0.006
  27. differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1. J Biol Chem. 2001 Dec 14; 276(50):47623-31.
    View in: PubMed
    Score: 0.006
  28. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. J Cell Biol. 2001 Jun 11; 153(6):1277-86.
    View in: PubMed
    Score: 0.006
  29. Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy. Bone Marrow Transplant. 2001 Jun; 27(12):1227-36.
    View in: PubMed
    Score: 0.006
  30. Emerging glyco-based strategies to steer immune responses. FEBS J. 2021 08; 288(16):4746-4772.
    View in: PubMed
    Score: 0.006
  31. Defibrotide inhibits donor leucocyte-endothelial interactions and protects against acute graft-versus-host disease. J Cell Mol Med. 2020 07; 24(14):8031-8044.
    View in: PubMed
    Score: 0.006
  32. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Nat Cell Biol. 2019 05; 21(5):627-639.
    View in: PubMed
    Score: 0.005
  33. Bone marrow mesenchymal stem/stromal cells from risk-stratified acute myeloid leukemia patients are anti-inflammatory in in vivo preclinical models of hematopoietic reconstitution and severe colitis. Haematologica. 2019 02; 104(2):e54-e58.
    View in: PubMed
    Score: 0.005
  34. Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression. Sci Rep. 2018 01 11; 8(1):420.
    View in: PubMed
    Score: 0.005
  35. mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors. J Clin Invest. 2017 Jun 01; 127(6):2433-2437.
    View in: PubMed
    Score: 0.004
  36. A hematopoietic cell L-selectin ligand exhibits sulfate-independent binding activity. Blood. 1997 Apr 15; 89(8):2773-81.
    View in: PubMed
    Score: 0.004
  37. Expression of an L-selectin ligand on hematopoietic progenitor cells. Acta Haematol. 1997; 97(1-2):22-8.
    View in: PubMed
    Score: 0.004
  38. Leukocyte-borne a(1,3)-fucose is a negative regulator of ß2-integrin-dependent recruitment in lung inflammation. J Leukoc Biol. 2017 02; 101(2):459-470.
    View in: PubMed
    Score: 0.004
  39. Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8.
    View in: PubMed
    Score: 0.004
  40. Physiologic basis of steroid-induced immunosuppression. Effects on lymphocyte migration to lymph nodes. J Fla Med Assoc. 1995 Sep; 82(9):613-5.
    View in: PubMed
    Score: 0.004
  41. Evidence of post-transcriptional regulation of L-selectin gene expression in rat lymphoid cells. Immunology. 1995 Jun; 85(2):198-204.
    View in: PubMed
    Score: 0.004
  42. The mechanisms of up-regulation of dendritic cell activity by oxidative stress. J Leukoc Biol. 2014 Aug; 96(2):283-93.
    View in: PubMed
    Score: 0.004
  43. Physiologic migration of lymphocytes to lymph nodes following bone marrow transplantation: role in immune recovery. Semin Oncol. 1993 Oct; 20(5 Suppl 6):34-9.
    View in: PubMed
    Score: 0.003
  44. CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture. J Tissue Eng Regen Med. 2013 Jul; 7(7):572-83.
    View in: PubMed
    Score: 0.003
  45. Desialylation accelerates platelet clearance after refrigeration and initiates GPIba metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 02; 119(5):1263-73.
    View in: PubMed
    Score: 0.003
  46. Lymphocyte recognition of psoriatic endothelium: evidence for a tissue-specific receptor/ligand interaction. J Invest Dermatol. 1989 Aug; 93(2 Suppl):82S-87S.
    View in: PubMed
    Score: 0.003
  47. Regulation of heparan sulfate and chondroitin sulfate glycosaminoglycan biosynthesis by 4-fluoro-glucosamine in murine airway smooth muscle cells. J Biol Chem. 2009 Jun 19; 284(25):16832-16839.
    View in: PubMed
    Score: 0.003
  48. Lymphocyte adhesion to psoriatic dermal endothelium is mediated by a tissue-specific receptor/ligand interaction. J Invest Dermatol. 1988 Nov; 91(5):423-8.
    View in: PubMed
    Score: 0.002
  49. Specific lymphocyte-endothelial cell interactions regulate migration into lymph nodes, Peyer's patches, and skin. Reg Immunol. 1988 Jul-Aug; 1(1):78-83.
    View in: PubMed
    Score: 0.002
  50. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5431-6.
    View in: PubMed
    Score: 0.002
  51. Molecular biology of the human and mouse MHC class III genes: phylogenetic conservation, genetics and regulation of expression. Immunol Rev. 1985 Oct; 87:185-208.
    View in: PubMed
    Score: 0.002
  52. Molecular regulation of MHC class III (C4 and factor B) gene expression in mouse peritoneal macrophages. J Immunol. 1984 Sep; 133(3):1618-26.
    View in: PubMed
    Score: 0.002
  53. Subdivision of the S region of the mouse major histocompatibility complex by identification of genomic polymorphisms of the class III genes. Immunogenetics. 1984; 20(3):321-30.
    View in: PubMed
    Score: 0.002
  54. Phylogenetic conservation of a class III major histocompatibility complex antigen, factor B. Isolation and nucleotide sequencing of mouse factor B cDNA clones. J Biol Chem. 1983 Dec 10; 258(23):14693-7.
    View in: PubMed
    Score: 0.002
  55. Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells. Transplantation. 2002 Oct 27; 74(8):1159-66.
    View in: PubMed
    Score: 0.002
  56. Porcine mononuclear cells adhere to human fibronectin independently of very late antigen-5: implications for donor-specific tolerance induction in xenotransplantation. Xenotransplantation. 2002 Jul; 9(4):277-89.
    View in: PubMed
    Score: 0.002
  57. Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. Transplantation. 2002 Jan 15; 73(1):12-22.
    View in: PubMed
    Score: 0.002
  58. Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. Transplantation. 2001 Jun 15; 71(11):1601-9.
    View in: PubMed
    Score: 0.001
  59. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation. 2000 Nov 15; 70(9):1323-31.
    View in: PubMed
    Score: 0.001
  60. Von willebrand factor concentration, multimeric patterns, and cleaving protease activity in baboons undergoing xenogeneic peripheral blood stem cell transplantation. Transplant Proc. 2000 Aug; 32(5):990.
    View in: PubMed
    Score: 0.001
  61. Coagulation/thrombotic disorders associated with organ and cell xenotransplantation. Transplant Proc. 2000 Aug; 32(5):1099.
    View in: PubMed
    Score: 0.001
  62. A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons. Transplant Proc. 2000 Aug; 32(5):1100.
    View in: PubMed
    Score: 0.001
  63. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation. 2000 Jun 15; 69(11):2296-304.
    View in: PubMed
    Score: 0.001
  64. Cytokine-mobilized peripheral blood progenitor cells for allogeneic reconstitution of miniature swine. Transplantation. 2000 Jan 15; 69(1):135-40.
    View in: PubMed
    Score: 0.001
  65. Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. Biol Blood Marrow Transplant. 2000; 6(3A):309-20.
    View in: PubMed
    Score: 0.001
  66. The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha. Blood. 1999 Dec 15; 94(12):4233-46.
    View in: PubMed
    Score: 0.001
  67. Expression of hemolytically active murine fourth component of complement in transfected L cells. Cell. 1984 Jun; 37(2):569-76.
    View in: PubMed
    Score: 0.000
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.