Harvard Catalyst Profiles

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Robert Sackstein, M.D.,Ph.D.

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Mentoring
Use of Glycotransferase-Programed Stereosubsitution (GPS) to improve targeted stem cell therapies in Traumatic Brain Injury
Summer, 06/13/13 - 08/19/13

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K12HL141953 (SACKSTEIN, ROBERT) Jul 1, 2018 - Jun 30, 2023
    NIH/NHLBI
    Forging Translational Glycobiologists: Intermeshing Glycoscience Training and Clinical Education
    Role Description: Training the next generation of "Translational Glycobiologists"
    Role: Principal Investigator
  2. P01HL107146 (SACKSTEIN, ROBERT) Jul 1, 2011 - May 31, 2018
    NIH/NHLBI
    Biosynthesis and Function of Lactosaminyl Glycans in Hematopoiesis
    Role Description: Elucidate the structure and biology of terminal lactosaminyl glycans in human blood cell development
    Role: Principal Investigator
  3. R01CA121335 (SACKSTEIN, ROBERT) Jul 1, 2007 - Jun 30, 2012
    NIH/NCI
    Molecular Analysis of CD44 on Colon Cancer Cells
    Role: Principal Investigator
  4. R21DK075012 (SACKSTEIN, ROBERT) Jul 1, 2007 - Jun 30, 2010
    NIH/NIDDK
    Characterization of A Novel 65kDa E-selectin Ligand on G-CSF Mobilized Leukocytes
    Role: Principal Investigator
  5. R01HL073714 (SACKSTEIN, ROBERT) Jul 11, 2003 - Jun 30, 2011
    NIH/NHLBI
    Optimizing Osteotropism of Human Mesenchymal Stem Cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Esposito M, Mondal N, Greco TM, Wei Y, Spadazzi C, Lin SC, Zheng H, Cheung C, Magnani JL, Lin SH, Cristea IM, Sackstein R, Kang Y. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Nat Cell Biol. 2019 May; 21(5):627-639. PMID: 30988423.
    Citations:    
  2. Sackstein R. The First Step in Adoptive Cell Immunotherapeutics: Assuring Cell Delivery via Glycoengineering. Front Immunol. 2018; 9:3084. PMID: 30687313.
    Citations:    
  3. de la Guardia RD, Lopez-Millan B, Roca-Ho H, Bueno C, Gutiérrez-Agüera F, Fuster JL, Anguita E, Zanetti SR, Vives S, Nomdedeu J, Sackstein R, Lavoie J, Gónzalez-Rey E, Delgado M, Rosu-Myles M, Menendez P. Bone marrow mesenchymal stem/stromal cells from risk-stratified acute myeloid leukemia patients are anti-inflammatory in in vivo preclinical models of hematopoietic reconstitution and severe colitis. Haematologica. 2019 Feb; 104(2):e54-e58. PMID: 30237260.
    Citations:    Fields:    
  4. López-Lucas MD, Pachón-Peña G, García-Hernández AM, Parrado A, Sánchez-Salinas D, García-Bernal D, Algueró MDC, Martinez FI, Blanquer M, Cabañas-Perianes V, Molina-Molina M, Asín-Aguilar C, Moraleda JM, Sackstein R. Production via good manufacturing practice of exofucosylated human mesenchymal stromal cells for clinical applications. Cytotherapy. 2018 Sep; 20(9):1110-1123. PMID: 30170815.
    Citations:    Fields:    
  5. Videira PA, Silva M, Martin KC, Sackstein R. Ligation of the CD44 Glycoform HCELL on Culture-Expanded Human Monocyte-Derived Dendritic Cells Programs Transendothelial Migration. J Immunol. 2018 Aug 01; 201(3):1030-1043. PMID: 29941663.
    Citations:    Fields:    
  6. Carrascal MA, Talina C, Borralho P, Gonçalo Mineiro A, Henriques AR, Pen C, Martins M, Braga S, Sackstein R, Videira PA. Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue. BMC Cancer. 2018 05 02; 18(1):495. PMID: 29716546.
    Citations:    Fields:    Translation:Humans
  7. Carrascal MA, Silva M, Ramalho JS, Pen C, Martins M, Pascoal C, Amaral C, Serrano I, Oliveira MJ, Sackstein R, Videira PA. Inhibition of fucosylation in human invasive ductal carcinoma reduces E-selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation. Mol Oncol. 2018 05; 12(5):579-593. PMID: 29215790.
    Citations: 2     Fields:    
  8. Mondal N, Dykstra B, Lee J, Ashline DJ, Reinhold VN, Rossi DJ, Sackstein R. Distinct human a(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells. J Biol Chem. 2018 05 11; 293(19):7300-7314. PMID: 29593094.
    Citations:    Fields:    Translation:Humans
  9. Wu ZL, Person AD, Anderson M, Burroughs B, Tatge T, Khatri K, Zou Y, Wang L, Geders T, Zaia J, Sackstein R. Imaging specific cellular glycan structures using glycosyltransferases via click chemistry. Glycobiology. 2018 02 01; 28(2):69-79. PMID: 29186441.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Silva M, Videira PA, Sackstein R. E-Selectin Ligands in the Human Mononuclear Phagocyte System: Implications for Infection, Inflammation, and Immunotherapy. Front Immunol. 2017; 8:1878. PMID: 29403469.
    Citations:    
  11. Donnelly C, Dykstra B, Mondal N, Huang J, Kaskow BJ, Griffin R, Sackstein R, Baecher-Allan C. Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression. Sci Rep. 2018 01 11; 8(1):420. PMID: 29323143.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Lee J, Dykstra B, Spencer JA, Kenney LL, Greiner DL, Shultz LD, Brehm MA, Lin CP, Sackstein R, Rossi DJ. mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors. J Clin Invest. 2017 Jun 01; 127(6):2433-2437. PMID: 28481220.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Sackstein R, Schatton T, Barthel SR. T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy. Lab Invest. 2017 06; 97(6):669-697. PMID: 28346400.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  14. Silva M, Fung RKF, Donnelly CB, Videira PA, Sackstein R. Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology. J Immunol. 2017 05 01; 198(9):3576-3587. PMID: 28330896.
    Citations: 2     Fields:    Translation:HumansCells
  15. Pachón-Peña G, Donnelly C, Ruiz-Cañada C, Katz A, Fernández-Veledo S, Vendrell J, Sackstein R. A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells. Stem Cells. 2017 04; 35(4):1080-1092. PMID: 27888602.
    Citations: 3     Fields:    Translation:HumansCells
  16. Buffone A, Nasirikenari M, Manhardt CT, Lugade A, Bogner PN, Sackstein R, Thanavala Y, Neelamegham S, Lau JT. Leukocyte-borne a(1,3)-fucose is a negative regulator of ß2-integrin-dependent recruitment in lung inflammation. J Leukoc Biol. 2017 02; 101(2):459-470. PMID: 27566832.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Dykstra B, Lee J, Mortensen LJ, Yu H, Wu ZL, Lin CP, Rossi DJ, Sackstein R. Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells. Stem Cells. 2016 10; 34(10):2501-2511. PMID: 27335219.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  18. Sackstein R. Translational glycobiology: Patient-oriented glycoscience research. Glycobiology. 2016 06; 26(6):544-5. PMID: 27122387.
    Citations:    
  19. Sackstein R. Fulfilling Koch's postulates in glycoscience: HCELL, GPS and translational glycobiology. Glycobiology. 2016 06; 26(6):560-70. PMID: 26933169.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  20. Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I. Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8. PMID: 26829621.
    Citations: 4     Fields:    Translation:HumansAnimals
  21. Merzaban JS, Imitola J, Starossom SC, Zhu B, Wang Y, Lee J, Ali AJ, Olah M, Abuelela AF, Khoury SJ, Sackstein R. Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple sclerosis. Glycobiology. 2015 Dec; 25(12):1392-409. PMID: 26153105.
    Citations: 13     Fields:    Translation:AnimalsCells
  22. Lee J, Dykstra B, Sackstein R, Rossi DJ. Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells. Curr Opin Hematol. 2015 Jul; 22(4):317-23. PMID: 26049752.
    Citations: 2     Fields:    Translation:HumansCells
  23. Abdi R, Moore R, Sakai S, Donnelly CB, Mounayar M, Sackstein R. HCELL Expression on Murine MSC Licenses Pancreatotropism and Confers Durable Reversal of Autoimmune Diabetes in NOD Mice. Stem Cells. 2015 May; 33(5):1523-31. PMID: 25641589.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  24. Sackstein R, Fuhlbrigge R. Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay. Methods Mol Biol. 2015; 1312:399-410. PMID: 26044020.
    Citations:    Fields:    Translation:AnimalsCells
  25. Silvescu CI, Sackstein R. G-CSF induces membrane expression of a myeloperoxidase glycovariant that operates as an E-selectin ligand on human myeloid cells. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10696-701. PMID: 25002508.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  26. Batal I, Azzi J, Mounayar M, Abdoli R, Moore R, Lee JY, Rosetti F, Wang C, Fiorina P, Sackstein R, Ichimura T, Abdi R. The mechanisms of up-regulation of dendritic cell activity by oxidative stress. J Leukoc Biol. 2014 Aug; 96(2):283-93. PMID: 24676276.
    Citations: 4     Fields:    Translation:AnimalsCells
  27. Dauber A, Ercan A, Lee J, James P, Jacobs PP, Ashline DJ, Wang SR, Miller T, Hirschhorn JN, Nigrovic PA, Sackstein R. Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect. Hum Mol Genet. 2014 Jun 01; 23(11):2880-7. PMID: 24403049.
    Citations: 2     Fields:    Translation:HumansCells
  28. Peter Y, Sen N, Levantini E, Keller S, Ingenito EP, Ciner A, Sackstein R, Shapiro SD. CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture. J Tissue Eng Regen Med. 2013 Jul; 7(7):572-83. PMID: 22585451.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  29. Sackstein R. Re: "Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2R?(null) mice". Exp Hematol. 2012 Jul; 40(7):518-9; author reply 519-20. PMID: 22507642.
    Citations: 1     Fields:    Translation:HumansAnimals
  30. Sackstein R. Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution. Ann N Y Acad Sci. 2012 Apr; 1253:193-200. PMID: 22352800.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  31. Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIba metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 02; 119(5):1263-73. PMID: 22101895.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  32. Sackstein R. Glycoengineering of HCELL, the human bone marrow homing receptor: sweetly programming cell migration. Ann Biomed Eng. 2012 Apr; 40(4):766-76. PMID: 22068886.
    Citations: 17     Fields:    Translation:HumansCells
  33. Jacobs PP, Sackstein R. CD44 and HCELL: preventing hematogenous metastasis at step 1. FEBS Lett. 2011 Oct 20; 585(20):3148-58. PMID: 21827751.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  34. Sackstein R. The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives. Curr Opin Hematol. 2011 Jul; 18(4):239-48. PMID: 21546828.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  35. Merzaban JS, Burdick MM, Gadhoum SZ, Dagia NM, Chu JT, Fuhlbrigge RC, Sackstein R. Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells. Blood. 2011 Aug 18; 118(7):1774-83. PMID: 21659548.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  36. Thankamony SP, Sackstein R. Enforced hematopoietic cell E- and L-selectin ligand (HCELL) expression primes transendothelial migration of human mesenchymal stem cells. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2258-63. PMID: 21257905.
    Citations: 35     Fields:    Translation:HumansCells
  37. Sackstein R. Hitting the sweet spot for lymphoma. Blood. 2010 Jun 10; 115(23):4626-7. PMID: 20538811.
    Citations: 1     Fields:    
  38. Sackstein R. Directing stem cell trafficking via GPS. Methods Enzymol. 2010; 479:93-105. PMID: 20816161.
    Citations: 4     Fields:    Translation:HumansCells
  39. Chester R, Sackstein R. Embryonic stem cell-based therapeutics: balancing scientific progress and bioethics. Health Matrix Clevel. 2010; 20(1):203-17. PMID: 20862929.
    Citations: 3     Fields:    Translation:HumansCells
  40. Lee JY, Buzney CD, Poznansky MC, Sackstein R. Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions. J Leukoc Biol. 2009 Dec; 86(6):1285-94. PMID: 19797295.
    Citations: 12     Fields:    Translation:HumansCells
  41. Sackstein R. Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration. Immunol Rev. 2009 Jul; 230(1):51-74. PMID: 19594629.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  42. Nigro J, Wang A, Mukhopadhyay D, Lauer M, Midura RJ, Sackstein R, Hascall VC. Regulation of heparan sulfate and chondroitin sulfate glycosaminoglycan biosynthesis by 4-fluoro-glucosamine in murine airway smooth muscle cells. J Biol Chem. 2009 Jun 19; 284(25):16832-9. PMID: 19346253.
    Citations: 13     Fields:    Translation:AnimalsCells
  43. Sackstein R, Fuhlbrigge R. Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay. Methods Mol Biol. 2009; 536:343-54. PMID: 19378073.
    Citations: 7     Fields:    Translation:AnimalsCells
  44. Gadhoum SZ, Sackstein R. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat Chem Biol. 2008 Dec; 4(12):751-7. PMID: 18953356.
    Citations: 21     Fields:    Translation:HumansCells
  45. Ngo HT, Leleu X, Lee J, Jia X, Melhem M, Runnels J, Moreau AS, Burwick N, Azab AK, Roccaro A, Azab F, Sacco A, Farag M, Sackstein R, Ghobrial IM. SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. Blood. 2008 Jul 01; 112(1):150-8. PMID: 18448868.
    Citations: 34     Fields:    Translation:HumansCells
  46. Resto VA, Burdick MM, Dagia NM, McCammon SD, Fennewald SM, Sackstein R. L-selectin-mediated lymphocyte-cancer cell interactions under low fluid shear conditions. J Biol Chem. 2008 Jun 06; 283(23):15816-24. PMID: 18385135.
    Citations: 17     Fields:    Translation:HumansCells
  47. Shaulov A, Yue S, Wang R, Joyce RM, Balk SP, Kim HT, Avigan DE, Uhl L, Sackstein R, Exley MA. Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: implications for posttransplant survival. Exp Hematol. 2008 Apr; 36(4):464-72. PMID: 18261838.
    Citations: 10     Fields:    Translation:HumansCells
  48. Sackstein R, Merzaban JS, Cain DW, Dagia NM, Spencer JA, Lin CP, Wohlgemuth R. Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med. 2008 Feb; 14(2):181-7. PMID: 18193058.
    Citations: 158     Fields:    Translation:HumansAnimalsCells
  49. Parmar K, Mauch P, Vergilio JA, Sackstein R, Down JD. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5431-6. PMID: 17374716.
    Citations: 252     Fields:    Translation:AnimalsCells
  50. Schreiber TH, Shinder V, Cain DW, Alon R, Sackstein R. Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm. Blood. 2007 Feb 15; 109(4):1381-6. PMID: 17038526.
    Citations: 32     Fields:    Translation:HumansCells
  51. Dagia NM, Gadhoum SZ, Knoblauch CA, Spencer JA, Zamiri P, Lin CP, Sackstein R. G-CSF induces E-selectin ligand expression on human myeloid cells. Nat Med. 2006 Oct; 12(10):1185-90. PMID: 16980970.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  52. Burdick MM, Chu JT, Godar S, Sackstein R. HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells. J Biol Chem. 2006 May 19; 281(20):13899-905. PMID: 16565092.
    Citations: 40     Fields:    Translation:HumansCells
  53. Sackstein R. A revision of Billingham's tenets: the central role of lymphocyte migration in acute graft-versus-host disease. Biol Blood Marrow Transplant. 2006 Jan; 12(1 Suppl 1):2-8. PMID: 16399577.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  54. Sackstein R, Fuhlbrigge R. The blot rolling assay: a method for identifying adhesion molecules mediating binding under shear conditions. Methods Mol Biol. 2006; 341:217-26. PMID: 16799202.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  55. Hanley WD, Napier SL, Burdick MM, Schnaar RL, Sackstein R, Konstantopoulos K. Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells. FASEB J. 2006 Feb; 20(2):337-9. PMID: 16352650.
    Citations: 47     Fields:    Translation:HumansCells
  56. Fuhlbrigge RC, King SL, Sackstein R, Kupper TS. CD43 is a ligand for E-selectin on CLA+ human T cells. Blood. 2006 Feb 15; 107(4):1421-6. PMID: 16269612.
    Citations: 39     Fields:    Translation:HumansCells
  57. Sackstein R. The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr Opin Hematol. 2005 Nov; 12(6):444-50. PMID: 16217160.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  58. Hanley WD, Burdick MM, Konstantopoulos K, Sackstein R. CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity. Cancer Res. 2005 Jul 01; 65(13):5812-7. PMID: 15994957.
    Citations: 42     Fields:    Translation:HumansCells
  59. Dey BR, McAfee S, Colby C, Cieply K, Caron M, Saidman S, Preffer F, Shaffer J, Tarbell N, Sackstein R, Sachs D, Sykes M, Spitzer TR. Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation. Br J Haematol. 2005 Feb; 128(3):351-9. PMID: 15667537.
    Citations: 27     Fields:    Translation:HumansCTClinical Trials
  60. Sackstein R. The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing. J Investig Dermatol Symp Proc. 2004 Sep; 9(3):215-23. PMID: 15369216.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  61. Sackstein R. The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing. J Invest Dermatol. 2004 May; 122(5):1061-9. PMID: 15140204.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  62. Elfenbein GJ, Sackstein R. Primed marrow for autologous and allogeneic transplantation: a review comparing primed marrow to mobilized blood and steady-state marrow. Exp Hematol. 2004 Apr; 32(4):327-39. PMID: 15050742.
    Citations: 12     Fields:    Translation:HumansCells
  63. Elfenbein GJ, Sackstein R, Oblon DJ. Do G-CSF mobilized, peripheral blood-derived stem cells from healthy, HLA-identical donors really engraft more rapidly than do G-CSF primed, bone marrow-derived stem cells? No! Blood Cells Mol Dis. 2004 Jan-Feb; 32(1):106-11. PMID: 14757423.
    Citations: 2     Fields:    Translation:HumansCells
  64. Dimitroff CJ, Kupper TS, Sackstein R. Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. J Clin Invest. 2003 Oct; 112(7):1008-18. PMID: 14523038.
    Citations: 25     Fields:    Translation:AnimalsCells
  65. Milinkovic M, Antin JH, Hergrueter CA, Underhill CB, Sackstein R. CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD. Blood. 2004 Jan 15; 103(2):740-2. PMID: 14504094.
    Citations: 18     Fields:    Translation:Humans
  66. Kraus AB, Shaffer J, Toh HC, Preffer F, Dombkowski D, Saidman S, Colby C, George R, McAfee S, Sackstein R, Dey B, Spitzer TR, Sykes M. Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation. Exp Hematol. 2003 Jul; 31(7):609-21. PMID: 12842706.
    Citations: 18     Fields:    Translation:HumansCells
  67. Daly A, McAfee S, Dey B, Colby C, Schulte L, Yeap B, Sackstein R, Tarbell NJ, Sachs D, Sykes M, Spitzer TR. Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants. Biol Blood Marrow Transplant. 2003 Jun; 9(6):373-82. PMID: 12813445.
    Citations: 13     Fields:    Translation:HumansCells
  68. Dey BR, McAfee S, Colby C, Sackstein R, Saidman S, Tarbell N, Sachs DH, Sykes M, Spitzer TR. Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2003 May; 9(5):320-9. PMID: 12766882.
    Citations: 33     Fields:    Translation:HumansCellsCTClinical Trials
  69. Toh HC, Spitzer TR, Preffer F, Alexander SI, McAfee S, Dombkowski D, Clark JS, Colby C, Saidman S, Sackstein R, Sykes M. Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical related allogeneic bone marrow transplant. Cytokines Cell Mol Ther. 2002 Dec; 7(2):43-7. PMID: 12607794.
    Citations: 4     Fields:    Translation:HumansCells
  70. Bühler LH, Spitzer TR, Sykes M, Sachs DH, Delmonico FL, Tolkoff-Rubin N, Saidman SL, Sackstein R, McAfee S, Dey B, Colby C, Cosimi AB. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation. 2002 Nov 27; 74(10):1405-9. PMID: 12451240.
    Citations: 45     Fields:    Translation:Humans
  71. Bühler L, Kurilla-Mahon B, Chang Q, Abraham S, Alwayn IP, Appel JZ, Newman D, Awwad M, White-Scharf ME, Sackstein R, Sachs DH, Cooper DK, Down JD. Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells. Transplantation. 2002 Oct 27; 74(8):1159-66. PMID: 12438964.
    Citations:    Fields:    Translation:HumansAnimalsCells
  72. Dimitroff CJ, Bernacki RJ, Sackstein R. Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin. Blood. 2003 Jan 15; 101(2):602-10. PMID: 12393521.
    Citations: 23     Fields:    Translation:HumansCells
  73. Sackstein R, Messina JL, Elfenbein GJ. In vitro adherence of lymphocytes to dermal endothelium under shear stress: implications in pathobiology and steroid therapy of acute cutaneous GVHD. Blood. 2003 Jan 15; 101(2):771-8. PMID: 12393384.
    Citations:    Fields:    Translation:HumansCells
  74. Theodore PR, Simon AR, Warrens AN, Sackstein R, Sykes M. Porcine mononuclear cells adhere to human fibronectin independently of very late antigen-5: implications for donor-specific tolerance induction in xenotransplantation. Xenotransplantation. 2002 Jul; 9(4):277-89. PMID: 12060464.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  75. Fuhlbrigge RC, King SL, Dimitroff CJ, Kupper TS, Sackstein R. Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots. J Immunol. 2002 Jun 01; 168(11):5645-51. PMID: 12023362.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  76. Bühler L, Awwad M, Treter S, Chang Q, Basker M, Alwayn IP, Teranishi K, Ericsson T, Moran K, Harper D, Kurilla-Mahon B, Huang CA, Sackstein R, Sykes M, White-Scharf ME, Sachs DH, Down JD, Cooper DK. Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. Transplantation. 2002 Jan 15; 73(1):12-22. PMID: 11792972.
    Citations: 8     Fields:    Translation:AnimalsCells
  77. Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, Avigan D, Sackstein R, Balk SP. A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol. 2001 Nov 15; 167(10):5531-4. PMID: 11698421.
    Citations: 52     Fields:    Translation:HumansCells
  78. Dimitroff CJ, Lee JY, Schor KS, Sandmaier BM, Sackstein R. differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1. J Biol Chem. 2001 Dec 14; 276(50):47623-31. PMID: 11591704.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  79. González S, Sackstein R, Anderson RR, Rajadhyaksha M. Real-time evidence of in vivo leukocyte trafficking in human skin by reflectance confocal microscopy. J Invest Dermatol. 2001 Aug; 117(2):384-6. PMID: 11511322.
    Citations: 7     Fields:    Translation:Humans
  80. Alwayn IP, Buhler L, Appel JZ, Goepfert C, Csizmadia E, Correa L, Harper D, Kitamura H, Down J, Awwad M, Sackstein R, Cooper DK, Robson SC. Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. Transplantation. 2001 Jun 15; 71(11):1601-9. PMID: 11435972.
    Citations: 6     Fields:    Translation:Animals
  81. Dimitroff CJ, Lee JY, Rafii S, Fuhlbrigge RC, Sackstein R. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. J Cell Biol. 2001 Jun 11; 153(6):1277-86. PMID: 11402070.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  82. Bühler L, Goepfert C, Kitamura H, Basker M, Gojo S, Alwayn IP, Chang Q, Down JD, Tsai H, Wise R, Sachs DH, Cooper DK, Robson SC, Sackstein R. Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy. Bone Marrow Transplant. 2001 Jun; 27(12):1227-36. PMID: 11548840.
    Citations: 5     Fields:    Translation:Animals
  83. Dey BR, McAfee S, Sackstein R, Colby C, Saidman S, Weymouth D, Poliquin C, Vanderklish J, Sachs DH, Sykes M, Spitzer TR. Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation. Biol Blood Marrow Transplant. 2001; 7(11):604-12. PMID: 11760148.
    Citations: 10     Fields:    Translation:Humans
  84. Dimitroff CJ, Lee JY, Fuhlbrigge RC, Sackstein R. A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13841-6. PMID: 11095749.
    Citations: 39     Fields:    Translation:HumansCells
  85. Bühler L, Basker M, Alwayn IP, Goepfert C, Kitamura H, Kawai T, Gojo S, Kozlowski T, Ierino FL, Awwad M, Sachs DH, Sackstein R, Robson SC, Cooper DK. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation. 2000 Nov 15; 70(9):1323-31. PMID: 11087147.
    Citations: 28     Fields:    Translation:HumansAnimals
  86. Sackstein R, Dimitroff CJ. A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity. Blood. 2000 Oct 15; 96(8):2765-74. PMID: 11023510.
    Citations: 22     Fields:    Translation:HumansCells
  87. Bühler L, Awwad M, Basker M, Gojo S, Thall A, Down JD, Sykes M, Andrews D, Sackstein R, White-Scharf ME, Sachs DH, Cooper DK. A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons. Transplant Proc. 2000 Aug; 32(5):1100. PMID: 10936377.
    Citations:    Fields:    Translation:AnimalsCells
  88. Gopfert C, Buhler L, Wise R, Basker M, Gojo S, Imai M, Alwayn I, Sachs DH, Sackstein R, Cooper DK, Robson SC. Von willebrand factor concentration, multimeric patterns, and cleaving protease activity in baboons undergoing xenogeneic peripheral blood stem cell transplantation. Transplant Proc. 2000 Aug; 32(5):990. PMID: 10936315.
    Citations:    Fields:    Translation:HumansAnimals
  89. Alwayn IP, Buhler L, Basker M, Goepfert C, Kawai T, Kozlowski T, Ierino F, Sachs DH, Sackstein R, Robson SC, Cooper DK. Coagulation/thrombotic disorders associated with organ and cell xenotransplantation. Transplant Proc. 2000 Aug; 32(5):1099. PMID: 10936376.
    Citations:    Fields:    Translation:Animals
  90. Bühler L, Awwad M, Basker M, Gojo S, Watts A, Treter S, Nash K, Oravec G, Chang Q, Thall A, Down JD, Sykes M, Andrews D, Sackstein R, White-Scharf ME, Sachs DH, Cooper DK. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation. 2000 Jun 15; 69(11):2296-304. PMID: 10868629.
    Citations: 27     Fields:    Translation:HumansAnimals
  91. Colby C, Chang Q, Fuchimoto Y, Ferrara V, Murphy M, Sackstein R, Spitzer TR, White-Scharf ME, Sachs DH. Cytokine-mobilized peripheral blood progenitor cells for allogeneic reconstitution of miniature swine. Transplantation. 2000 Jan 15; 69(1):135-40. PMID: 10653392.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  92. Toh HC, McAfee SL, Sackstein R, Multani P, Cox BF, Garcia-Carbonero R, Colby C, Spitzer TR. High-dose cyclophosphamide + carboplatin and interleukin-2 (IL-2) activated autologous stem cell transplantation followed by maintenance IL-2 therapy in metastatic breast carcinoma - a phase II study. Bone Marrow Transplant. 2000 Jan; 25(1):19-24. PMID: 10654009.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  93. Spitzer TR, McAfee S, Sackstein R, Colby C, Toh HC, Multani P, Saidman S, Weyouth DW, Preffer F, Poliquin C, Foley A, Cox B, Andrews D, Sachs DH, Sykes M. Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. Biol Blood Marrow Transplant. 2000; 6(3A):309-20. PMID: 10905768.
    Citations: 42     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  94. Salgia R, Quackenbush E, Lin J, Souchkova N, Sattler M, Ewaniuk DS, Klucher KM, Daley GQ, Kraeft SK, Sackstein R, Alyea EP, von Andrian UH, Chen LB, Gutierrez-Ramos JC, Pendergast AM, Griffin JD. The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha. Blood. 1999 Dec 15; 94(12):4233-46. PMID: 10590068.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  95. Colby C, McAfee S, Sackstein R, Finkelstein D, Fishman J, Spitzer T. A prospective randomized trial comparing the toxicity and safety of atovaquone with trimethoprim/sulfamethoxazole as Pneumocystis carinii pneumonia prophylaxis following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1999 Oct; 24(8):897-902. PMID: 10516703.
    Citations: 7     Fields:    Translation:HumansAnimalsCTClinical Trials
  96. Toh HC, McAfee SL, Sackstein R, Cox BF, Colby C, Spitzer TR. Late onset veno-occlusive disease following high-dose chemotherapy and stem cell transplantation. Bone Marrow Transplant. 1999 Oct; 24(8):891-5. PMID: 10516702.
    Citations: 12     Fields:    Translation:Humans
  97. Spitzer TR, Delmonico F, Tolkoff-Rubin N, McAfee S, Sackstein R, Saidman S, Colby C, Sykes M, Sachs DH, Cosimi AB. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation. 1999 Aug 27; 68(4):480-4. PMID: 10480403.
    Citations: 67     Fields:    Translation:Humans
  98. Sykes M, Preffer F, McAfee S, Saidman SL, Weymouth D, Andrews DM, Colby C, Sackstein R, Sachs DH, Spitzer TR. Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation. Lancet. 1999 May 22; 353(9166):1755-9. PMID: 10347989.
    Citations: 48     Fields:    Translation:HumansCTClinical Trials
  99. Ballester OF, Tummala R, Janssen WE, Fields KK, Hiemenz JW, Goldstein SC, Perkins JB, Sullivan DM, Rosen R, Sackstein R, Zorsky P, Saez R, Elfenbein GJ. High-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with multiple myeloma and renal insufficiency. Bone Marrow Transplant. 1997 Oct; 20(8):653-6. PMID: 9383228.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  100. Sackstein R, Fu L, Allen KL. A hematopoietic cell L-selectin ligand exhibits sulfate-independent binding activity. Blood. 1997 Apr 15; 89(8):2773-81. PMID: 9108395.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  101. Sackstein R. Expression of an L-selectin ligand on hematopoietic progenitor cells. Acta Haematol. 1997; 97(1-2):22-8. PMID: 8980607.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  102. Wasik MA, Sackstein R, Novick D, Butmarc JR, Zhang Q, Vonderheid EC, Kadin ME. Cutaneous CD56+ large T-cell lymphoma associated with high serum concentration of IL-2. Hum Pathol. 1996 Jul; 27(7):738-44. PMID: 8698322.
    Citations: 1     Fields:    Translation:Humans
  103. Sackstein R. Lymphocyte migration following bone marrow transplantation. Ann N Y Acad Sci. 1995 Dec 29; 770:177-88. PMID: 8597359.
    Citations: 2     Fields:    Translation:HumansCells
  104. Sackstein R. Physiologic basis of steroid-induced immunosuppression. Effects on lymphocyte migration to lymph nodes. J Fla Med Assoc. 1995 Sep; 82(9):613-5. PMID: 7595343.
    Citations:    Fields:    Translation:HumansAnimalsCells
  105. Sackstein R, Meng L, Xu XM, Chin YH. Evidence of post-transcriptional regulation of L-selectin gene expression in rat lymphoid cells. Immunology. 1995 Jun; 85(2):198-204. PMID: 7543874.
    Citations: 1     Fields:    Translation:AnimalsCells
  106. Sackstein R, Borenstein M. The effects of corticosteroids on lymphocyte recirculation in humans: analysis of the mechanism of impaired lymphocyte migration to lymph node following methylprednisolone administration. J Investig Med. 1995 Feb; 43(1):68-77. PMID: 7719761.
    Citations: 7     Fields:    Translation:HumansCellsCTClinical Trials
  107. Oxley SM, Sackstein R. Detection of an L-selectin ligand on a hematopoietic progenitor cell line. Blood. 1994 Nov 15; 84(10):3299-306. PMID: 7524735.
    Citations: 15     Fields:    Translation:HumansCells
  108. Sackstein R. Adoptive Immunotherapy: The Magic Bullet of Cancer Therapy? Cancer Control. 1994 Jan; 1(1):65-66. PMID: 10886954.
    Citations:    Fields:    
  109. Sackstein R. Effects of methylprednisolone administration on lymphocyte LECAM-1, CD44, and LFA-1 expression. Implications for steroid-induced lymphopenia. Ann N Y Acad Sci. 1993 Nov 30; 696:417-9. PMID: 7509137.
    Citations:    Fields:    Translation:HumansCells
  110. Sackstein R. Physiologic migration of lymphocytes to lymph nodes following bone marrow transplantation: role in immune recovery. Semin Oncol. 1993 Oct; 20(5 Suppl 6):34-9. PMID: 7692606.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  111. Chin YH, Sackstein R, Cai JP. Lymphocyte-homing receptors and preferential migration pathways. Proc Soc Exp Biol Med. 1991 Apr; 196(4):374-80. PMID: 2008438.
    Citations: 5     Fields:    Translation:HumansCells
  112. Chin YH, Falanga V, Streilein JW, Sackstein R. Lymphocyte recognition of psoriatic endothelium: evidence for a tissue-specific receptor/ligand interaction. J Invest Dermatol. 1989 Aug; 93(2 Suppl):82S-87S. PMID: 2546996.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  113. Sackstein R, Falanga V, Streilein JW, Chin YH. Lymphocyte adhesion to psoriatic dermal endothelium is mediated by a tissue-specific receptor/ligand interaction. J Invest Dermatol. 1988 Nov; 91(5):423-8. PMID: 3262692.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  114. Chin YH, Falanga V, Streilein JW, Sackstein R. Specific lymphocyte-endothelial cell interactions regulate migration into lymph nodes, Peyer's patches, and skin. Reg Immunol. 1988 Jul-Aug; 1(1):78-83. PMID: 3079311.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  115. Whitehead AS, Sackstein R. Molecular biology of the human and mouse MHC class III genes: phylogenetic conservation, genetics and regulation of expression. Immunol Rev. 1985 Oct; 87:185-208. PMID: 3902622.
    Citations: 2     Fields:    Translation:HumansAnimals
  116. Sackstein R, Colten HR. Molecular regulation of MHC class III (C4 and factor B) gene expression in mouse peritoneal macrophages. J Immunol. 1984 Sep; 133(3):1618-26. PMID: 6205089.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  117. Chaplin DD, Sackstein R, Perlmutter DH, Weis JH, Kruse TA, Coligan J, Colten HR, Seidman JG. Expression of hemolytically active murine fourth component of complement in transfected L cells. Cell. 1984 Jun; 37(2):569-76. PMID: 6327077.
    Citations: 13     Fields:    Translation:AnimalsCells
  118. Sackstein R, Roos MH, Démant P, Colten HR. Subdivision of the S region of the mouse major histocompatibility complex by identification of genomic polymorphisms of the class III genes. Immunogenetics. 1984; 20(3):321-30. PMID: 6088393.
    Citations: 10     Fields:    Translation:Animals
  119. Sackstein R, Colten HR, Woods DE. Phylogenetic conservation of a class III major histocompatibility complex antigen, factor B. Isolation and nucleotide sequencing of mouse factor B cDNA clones. J Biol Chem. 1983 Dec 10; 258(23):14693-7. PMID: 6689022.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.