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profileRobert Sackstein, M.D.,Ph.D.

TitleProfessor of Dermatology
InstitutionBrigham and Women's Hospital
DepartmentDermatology
AddressHarvard Institutes of Medicine
Room 671
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-5601
Fax617/525-5571
vCardDownload vCard (login for email)
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Other Positions
TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
DivisionHematology


Collapse Mentoring 
Collapse completed student projects
Use of Glycotransferase-Programed Stereosubsitution (GPS) to improve targeted stem cell therapies in Traumatic Brain Injury
Summer, 06/13/13 - 08/19/13

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
P01HL107146     (SACKSTEIN, ROBERT)Jul 1, 2011 - May 31, 2018
NIH/NHLBI
Biosynthesis and Function of Lactosaminyl Glycans in Hematopoiesis
Role: Principal Investigator

R01CA121335     (SACKSTEIN, ROBERT)Jul 1, 2007 - Jun 30, 2012
NIH/NCI
Molecular Analysis of CD44 on Colon Cancer Cells
Role: Principal Investigator

R21DK075012     (SACKSTEIN, ROBERT)Jul 1, 2007 - Jun 30, 2010
NIH/NIDDK
Characterization of A Novel 65kDa E-selectin Ligand on G-CSF Mobilized Leukocytes
Role: Principal Investigator

R01HL073714     (SACKSTEIN, ROBERT)Jul 11, 2003 - Jun 30, 2011
NIH/NHLBI
Optimizing Osteotropism of Human Mesenchymal Stem Cells
Role: Principal Investigator

R01CA084156     (SACKSTEIN, ROBERT)May 1, 2000 - Apr 30, 2005
NIH/NCI
ADHESION MOLECULES MEDIATING SKIN TROPISM IN ACUTE GVHD
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee J, Dykstra B, Spencer JA, Kenney LL, Greiner DL, Shultz LD, Brehm MA, Lin CP, Sackstein R, Rossi DJ. mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors. J Clin Invest. 2017 Jun 01; 127(6):2433-2437. PMID: 28481220.
    View in: PubMed
  2. Sackstein R, Schatton T, Barthel SR. T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy. Lab Invest. 2017 Jun; 97(6):669-697. PMID: 28346400.
    View in: PubMed
  3. Silva M, Fung RKF, Donnelly CB, Videira PA, Sackstein R. Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology. J Immunol. 2017 May 01; 198(9):3576-3587. PMID: 28330896.
    View in: PubMed
  4. Pachón-Peña G, Donnelly C, Ruiz-Cañada C, Katz A, Fernández-Veledo S, Vendrell J, Sackstein R. A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells. Stem Cells. 2017 Apr; 35(4):1080-1092. PMID: 27888602.
    View in: PubMed
  5. Buffone A, Nasirikenari M, Manhardt CT, Lugade A, Bogner PN, Sackstein R, Thanavala Y, Neelamegham S, Lau JT. Leukocyte-borne a(1,3)-fucose is a negative regulator of ß2-integrin-dependent recruitment in lung inflammation. J Leukoc Biol. 2017 Feb; 101(2):459-470. PMID: 27566832.
    View in: PubMed
  6. Dykstra B, Lee J, Mortensen LJ, Yu H, Wu ZL, Lin CP, Rossi DJ, Sackstein R. Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells. Stem Cells. 2016 Oct; 34(10):2501-2511. PMID: 27335219.
    View in: PubMed
  7. Sackstein R. Translational glycobiology: Patient-oriented glycoscience research. Glycobiology. 2016 06; 26(6):544-5. PMID: 27122387.
    View in: PubMed
  8. Sackstein R. Fulfilling Koch's postulates in glycoscience: HCELL, GPS and translational glycobiology. Glycobiology. 2016 Jun; 26(6):560-70. PMID: 26933169; PMCID: PMC4847618 [Available on 06/01/17].
  9. Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I. Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8. PMID: 26829621; PMCID: PMC4731185 [Available on 02/01/17].
  10. Merzaban JS, Imitola J, Starossom SC, Zhu B, Wang Y, Lee J, Ali AJ, Olah M, Abuelela AF, Khoury SJ, Sackstein R. Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple sclerosis. Glycobiology. 2015 Dec; 25(12):1392-409. PMID: 26153105; PMCID: PMC4634313 [Available on 12/01/16].
  11. Lee J, Dykstra B, Sackstein R, Rossi DJ. Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells. Curr Opin Hematol. 2015 Jul; 22(4):317-23. PMID: 26049752; PMCID: PMC4459525.
  12. Abdi R, Moore R, Sakai S, Donnelly CB, Mounayar M, Sackstein R. HCELL Expression on Murine MSC Licenses Pancreatotropism and Confers Durable Reversal of Autoimmune Diabetes in NOD Mice. Stem Cells. 2015 May; 33(5):1523-31. PMID: 25641589; PMCID: PMC4447299.
  13. Sackstein R, Fuhlbrigge R. Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay. Methods Mol Biol. 2015; 1312:399-410. PMID: 26044020.
    View in: PubMed
  14. Silvescu CI, Sackstein R. G-CSF induces membrane expression of a myeloperoxidase glycovariant that operates as an E-selectin ligand on human myeloid cells. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10696-701. PMID: 25002508; PMCID: PMC4115493.
  15. Batal I, Azzi J, Mounayar M, Abdoli R, Moore R, Lee JY, Rosetti F, Wang C, Fiorina P, Sackstein R, Ichimura T, Abdi R. The mechanisms of up-regulation of dendritic cell activity by oxidative stress. J Leukoc Biol. 2014 Aug; 96(2):283-93. PMID: 24676276; PMCID: PMC4101089.
  16. Dauber A, Ercan A, Lee J, James P, Jacobs PP, Ashline DJ, Wang SR, Miller T, Hirschhorn JN, Nigrovic PA, Sackstein R. Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect. Hum Mol Genet. 2014 Jun 01; 23(11):2880-7. PMID: 24403049; PMCID: PMC4014190.
  17. Peter Y, Sen N, Levantini E, Keller S, Ingenito EP, Ciner A, Sackstein R, Shapiro SD. CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture. J Tissue Eng Regen Med. 2013 Jul; 7(7):572-83. PMID: 22585451; PMCID: PMC4434406.
  18. Sackstein R. Re: "Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2R?(null) mice". Exp Hematol. 2012 Jul; 40(7):518-9; author reply 519-20. PMID: 22507642.
    View in: PubMed
  19. Sackstein R. Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution. Ann N Y Acad Sci. 2012 Apr; 1253:193-200. PMID: 22352800; PMCID: PMC3336002.
  20. Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIba metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 02; 119(5):1263-73. PMID: 22101895; PMCID: PMC3277358.
  21. Sackstein R. Glycoengineering of HCELL, the human bone marrow homing receptor: sweetly programming cell migration. Ann Biomed Eng. 2012 Apr; 40(4):766-76. PMID: 22068886; PMCID: PMC3311703.
  22. Jacobs PP, Sackstein R. CD44 and HCELL: preventing hematogenous metastasis at step 1. FEBS Lett. 2011 Oct 20; 585(20):3148-58. PMID: 21827751; PMCID: PMC3195965.
  23. Sackstein R. The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives. Curr Opin Hematol. 2011 Jul; 18(4):239-48. PMID: 21546828; PMCID: PMC3145154.
  24. Merzaban JS, Burdick MM, Gadhoum SZ, Dagia NM, Chu JT, Fuhlbrigge RC, Sackstein R. Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells. Blood. 2011 Aug 18; 118(7):1774-83. PMID: 21659548; PMCID: PMC3158712.
  25. Thankamony SP, Sackstein R. Enforced hematopoietic cell E- and L-selectin ligand (HCELL) expression primes transendothelial migration of human mesenchymal stem cells. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2258-63. PMID: 21257905; PMCID: PMC3038774.
  26. Sackstein R. Hitting the sweet spot for lymphoma. Blood. 2010 Jun 10; 115(23):4626-7. PMID: 20538811.
    View in: PubMed
  27. Sackstein R. Directing stem cell trafficking via GPS. Methods Enzymol. 2010; 479:93-105. PMID: 20816161.
    View in: PubMed
  28. Chester R, Sackstein R. Embryonic stem cell-based therapeutics: balancing scientific progress and bioethics. Health Matrix Clevel. 2010; 20(1):203-17. PMID: 20862929.
    View in: PubMed
  29. Lee JY, Buzney CD, Poznansky MC, Sackstein R. Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions. J Leukoc Biol. 2009 Dec; 86(6):1285-94. PMID: 19797295; PMCID: PMC2796626.
  30. Sackstein R. Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration. Immunol Rev. 2009 Jul; 230(1):51-74. PMID: 19594629; PMCID: PMC4306344.
  31. Nigro J, Wang A, Mukhopadhyay D, Lauer M, Midura RJ, Sackstein R, Hascall VC. Regulation of heparan sulfate and chondroitin sulfate glycosaminoglycan biosynthesis by 4-fluoro-glucosamine in murine airway smooth muscle cells. J Biol Chem. 2009 Jun 19; 284(25):16832-9. PMID: 19346253; PMCID: PMC2719319.
  32. Sackstein R, Fuhlbrigge R. Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay. Methods Mol Biol. 2009; 536:343-54. PMID: 19378073.
    View in: PubMed
  33. Gadhoum SZ, Sackstein R. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat Chem Biol. 2008 Dec; 4(12):751-7. PMID: 18953356; PMCID: PMC2597094.
  34. Ngo HT, Leleu X, Lee J, Jia X, Melhem M, Runnels J, Moreau AS, Burwick N, Azab AK, Roccaro A, Azab F, Sacco A, Farag M, Sackstein R, Ghobrial IM. SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. Blood. 2008 Jul 01; 112(1):150-8. PMID: 18448868; PMCID: PMC2435685.
  35. Resto VA, Burdick MM, Dagia NM, McCammon SD, Fennewald SM, Sackstein R. L-selectin-mediated lymphocyte-cancer cell interactions under low fluid shear conditions. J Biol Chem. 2008 Jun 06; 283(23):15816-24. PMID: 18385135; PMCID: PMC2414279.
  36. Shaulov A, Yue S, Wang R, Joyce RM, Balk SP, Kim HT, Avigan DE, Uhl L, Sackstein R, Exley MA. Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: implications for posttransplant survival. Exp Hematol. 2008 Apr; 36(4):464-72. PMID: 18261838; PMCID: PMC2390922.
  37. Sackstein R, Merzaban JS, Cain DW, Dagia NM, Spencer JA, Lin CP, Wohlgemuth R. Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med. 2008 Feb; 14(2):181-7. PMID: 18193058.
    View in: PubMed
  38. Parmar K, Mauch P, Vergilio JA, Sackstein R, Down JD. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5431-6. PMID: 17374716; PMCID: PMC1838452.
  39. Schreiber TH, Shinder V, Cain DW, Alon R, Sackstein R. Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm. Blood. 2007 Feb 15; 109(4):1381-6. PMID: 17038526; PMCID: PMC1794074.
  40. Dagia NM, Gadhoum SZ, Knoblauch CA, Spencer JA, Zamiri P, Lin CP, Sackstein R. G-CSF induces E-selectin ligand expression on human myeloid cells. Nat Med. 2006 Oct; 12(10):1185-90. PMID: 16980970.
    View in: PubMed
  41. Burdick MM, Chu JT, Godar S, Sackstein R. HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells. J Biol Chem. 2006 May 19; 281(20):13899-905. PMID: 16565092.
    View in: PubMed
  42. Sackstein R. A revision of Billingham's tenets: the central role of lymphocyte migration in acute graft-versus-host disease. Biol Blood Marrow Transplant. 2006 Jan; 12(1 Suppl 1):2-8. PMID: 16399577.
    View in: PubMed
  43. Sackstein R, Fuhlbrigge R. The blot rolling assay: a method for identifying adhesion molecules mediating binding under shear conditions. Methods Mol Biol. 2006; 341:217-26. PMID: 16799202.
    View in: PubMed
  44. Hanley WD, Napier SL, Burdick MM, Schnaar RL, Sackstein R, Konstantopoulos K. Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells. FASEB J. 2006 Feb; 20(2):337-9. PMID: 16352650.
    View in: PubMed
  45. Fuhlbrigge RC, King SL, Sackstein R, Kupper TS. CD43 is a ligand for E-selectin on CLA+ human T cells. Blood. 2006 Feb 15; 107(4):1421-6. PMID: 16269612; PMCID: PMC1895405.
  46. Sackstein R. The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr Opin Hematol. 2005 Nov; 12(6):444-50. PMID: 16217160.
    View in: PubMed
  47. Hanley WD, Burdick MM, Konstantopoulos K, Sackstein R. CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity. Cancer Res. 2005 Jul 01; 65(13):5812-7. PMID: 15994957.
    View in: PubMed
  48. Dey BR, McAfee S, Colby C, Cieply K, Caron M, Saidman S, Preffer F, Shaffer J, Tarbell N, Sackstein R, Sachs D, Sykes M, Spitzer TR. Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation. Br J Haematol. 2005 Feb; 128(3):351-9. PMID: 15667537.
    View in: PubMed
  49. Sackstein R. The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing. J Investig Dermatol Symp Proc. 2004 Sep; 9(3):215-23. PMID: 15369216.
    View in: PubMed
  50. Sackstein R. The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing. J Invest Dermatol. 2004 May; 122(5):1061-9. PMID: 15140204.
    View in: PubMed
  51. Elfenbein GJ, Sackstein R. Primed marrow for autologous and allogeneic transplantation: a review comparing primed marrow to mobilized blood and steady-state marrow. Exp Hematol. 2004 Apr; 32(4):327-39. PMID: 15050742.
    View in: PubMed
  52. Elfenbein GJ, Sackstein R, Oblon DJ. Do G-CSF mobilized, peripheral blood-derived stem cells from healthy, HLA-identical donors really engraft more rapidly than do G-CSF primed, bone marrow-derived stem cells? No! Blood Cells Mol Dis. 2004 Jan-Feb; 32(1):106-11. PMID: 14757423.
    View in: PubMed
  53. Dimitroff CJ, Kupper TS, Sackstein R. Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. J Clin Invest. 2003 Oct; 112(7):1008-18. PMID: 14523038; PMCID: PMC198531.
  54. Milinkovic M, Antin JH, Hergrueter CA, Underhill CB, Sackstein R. CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD. Blood. 2004 Jan 15; 103(2):740-2. PMID: 14504094.
    View in: PubMed
  55. Kraus AB, Shaffer J, Toh HC, Preffer F, Dombkowski D, Saidman S, Colby C, George R, McAfee S, Sackstein R, Dey B, Spitzer TR, Sykes M. Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation. Exp Hematol. 2003 Jul; 31(7):609-21. PMID: 12842706.
    View in: PubMed
  56. Daly A, McAfee S, Dey B, Colby C, Schulte L, Yeap B, Sackstein R, Tarbell NJ, Sachs D, Sykes M, Spitzer TR. Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants. Biol Blood Marrow Transplant. 2003 Jun; 9(6):373-82. PMID: 12813445.
    View in: PubMed
  57. Dey BR, McAfee S, Colby C, Sackstein R, Saidman S, Tarbell N, Sachs DH, Sykes M, Spitzer TR. Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2003 May; 9(5):320-9. PMID: 12766882.
    View in: PubMed
  58. Toh HC, Spitzer TR, Preffer F, Alexander SI, McAfee S, Dombkowski D, Clark JS, Colby C, Saidman S, Sackstein R, Sykes M. Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical related allogeneic bone marrow transplant. Cytokines Cell Mol Ther. 2002 Dec; 7(2):43-7. PMID: 12607794.
    View in: PubMed
  59. Bühler LH, Spitzer TR, Sykes M, Sachs DH, Delmonico FL, Tolkoff-Rubin N, Saidman SL, Sackstein R, McAfee S, Dey B, Colby C, Cosimi AB. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation. 2002 Nov 27; 74(10):1405-9. PMID: 12451240.
    View in: PubMed
  60. Bühler L, Kurilla-Mahon B, Chang Q, Abraham S, Alwayn IP, Appel JZ, Newman D, Awwad M, White-Scharf ME, Sackstein R, Sachs DH, Cooper DK, Down JD. Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells. Transplantation. 2002 Oct 27; 74(8):1159-66. PMID: 12438964.
    View in: PubMed
  61. Dimitroff CJ, Bernacki RJ, Sackstein R. Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin. Blood. 2003 Jan 15; 101(2):602-10. PMID: 12393521.
    View in: PubMed
  62. Sackstein R, Messina JL, Elfenbein GJ. In vitro adherence of lymphocytes to dermal endothelium under shear stress: implications in pathobiology and steroid therapy of acute cutaneous GVHD. Blood. 2003 Jan 15; 101(2):771-8. PMID: 12393384.
    View in: PubMed
  63. Theodore PR, Simon AR, Warrens AN, Sackstein R, Sykes M. Porcine mononuclear cells adhere to human fibronectin independently of very late antigen-5: implications for donor-specific tolerance induction in xenotransplantation. Xenotransplantation. 2002 Jul; 9(4):277-89. PMID: 12060464.
    View in: PubMed
  64. Fuhlbrigge RC, King SL, Dimitroff CJ, Kupper TS, Sackstein R. Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots. J Immunol. 2002 Jun 01; 168(11):5645-51. PMID: 12023362.
    View in: PubMed
  65. Bühler L, Awwad M, Treter S, Chang Q, Basker M, Alwayn IP, Teranishi K, Ericsson T, Moran K, Harper D, Kurilla-Mahon B, Huang CA, Sackstein R, Sykes M, White-Scharf ME, Sachs DH, Down JD, Cooper DK. Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. Transplantation. 2002 Jan 15; 73(1):12-22. PMID: 11792972.
    View in: PubMed
  66. Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, Avigan D, Sackstein R, Balk SP. A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol. 2001 Nov 15; 167(10):5531-4. PMID: 11698421.
    View in: PubMed
  67. Dimitroff CJ, Lee JY, Schor KS, Sandmaier BM, Sackstein R. differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1. J Biol Chem. 2001 Dec 14; 276(50):47623-31. PMID: 11591704.
    View in: PubMed
  68. González S, Sackstein R, Anderson RR, Rajadhyaksha M. Real-time evidence of in vivo leukocyte trafficking in human skin by reflectance confocal microscopy. J Invest Dermatol. 2001 Aug; 117(2):384-6. PMID: 11511322.
    View in: PubMed
  69. Alwayn IP, Buhler L, Appel JZ, Goepfert C, Csizmadia E, Correa L, Harper D, Kitamura H, Down J, Awwad M, Sackstein R, Cooper DK, Robson SC. Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. Transplantation. 2001 Jun 15; 71(11):1601-9. PMID: 11435972.
    View in: PubMed
  70. Dimitroff CJ, Lee JY, Rafii S, Fuhlbrigge RC, Sackstein R. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. J Cell Biol. 2001 Jun 11; 153(6):1277-86. PMID: 11402070; PMCID: PMC2192031.
  71. Bühler L, Goepfert C, Kitamura H, Basker M, Gojo S, Alwayn IP, Chang Q, Down JD, Tsai H, Wise R, Sachs DH, Cooper DK, Robson SC, Sackstein R. Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy. Bone Marrow Transplant. 2001 Jun; 27(12):1227-36. PMID: 11548840.
    View in: PubMed
  72. Dey BR, McAfee S, Sackstein R, Colby C, Saidman S, Weymouth D, Poliquin C, Vanderklish J, Sachs DH, Sykes M, Spitzer TR. Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation. Biol Blood Marrow Transplant. 2001; 7(11):604-12. PMID: 11760148.
    View in: PubMed
  73. Dimitroff CJ, Lee JY, Fuhlbrigge RC, Sackstein R. A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13841-6. PMID: 11095749; PMCID: PMC17663.
  74. Bühler L, Basker M, Alwayn IP, Goepfert C, Kitamura H, Kawai T, Gojo S, Kozlowski T, Ierino FL, Awwad M, Sachs DH, Sackstein R, Robson SC, Cooper DK. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation. 2000 Nov 15; 70(9):1323-31. PMID: 11087147.
    View in: PubMed
  75. Sackstein R, Dimitroff CJ. A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity. Blood. 2000 Oct 15; 96(8):2765-74. PMID: 11023510.
    View in: PubMed
  76. Bühler L, Awwad M, Basker M, Gojo S, Thall A, Down JD, Sykes M, Andrews D, Sackstein R, White-Scharf ME, Sachs DH, Cooper DK. A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons. Transplant Proc. 2000 Aug; 32(5):1100. PMID: 10936377.
    View in: PubMed
  77. Gopfert C, Buhler L, Wise R, Basker M, Gojo S, Imai M, Alwayn I, Sachs DH, Sackstein R, Cooper DK, Robson SC. Von willebrand factor concentration, multimeric patterns, and cleaving protease activity in baboons undergoing xenogeneic peripheral blood stem cell transplantation. Transplant Proc. 2000 Aug; 32(5):990. PMID: 10936315.
    View in: PubMed
  78. Alwayn IP, Buhler L, Basker M, Goepfert C, Kawai T, Kozlowski T, Ierino F, Sachs DH, Sackstein R, Robson SC, Cooper DK. Coagulation/thrombotic disorders associated with organ and cell xenotransplantation. Transplant Proc. 2000 Aug; 32(5):1099. PMID: 10936376.
    View in: PubMed
  79. Bühler L, Awwad M, Basker M, Gojo S, Watts A, Treter S, Nash K, Oravec G, Chang Q, Thall A, Down JD, Sykes M, Andrews D, Sackstein R, White-Scharf ME, Sachs DH, Cooper DK. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation. 2000 Jun 15; 69(11):2296-304. PMID: 10868629.
    View in: PubMed
  80. Colby C, Chang Q, Fuchimoto Y, Ferrara V, Murphy M, Sackstein R, Spitzer TR, White-Scharf ME, Sachs DH. Cytokine-mobilized peripheral blood progenitor cells for allogeneic reconstitution of miniature swine. Transplantation. 2000 Jan 15; 69(1):135-40. PMID: 10653392.
    View in: PubMed
  81. Toh HC, McAfee SL, Sackstein R, Multani P, Cox BF, Garcia-Carbonero R, Colby C, Spitzer TR. High-dose cyclophosphamide + carboplatin and interleukin-2 (IL-2) activated autologous stem cell transplantation followed by maintenance IL-2 therapy in metastatic breast carcinoma - a phase II study. Bone Marrow Transplant. 2000 Jan; 25(1):19-24. PMID: 10654009.
    View in: PubMed
  82. Spitzer TR, McAfee S, Sackstein R, Colby C, Toh HC, Multani P, Saidman S, Weyouth DW, Preffer F, Poliquin C, Foley A, Cox B, Andrews D, Sachs DH, Sykes M. Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. Biol Blood Marrow Transplant. 2000; 6(3A):309-20. PMID: 10905768.
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  83. Salgia R, Quackenbush E, Lin J, Souchkova N, Sattler M, Ewaniuk DS, Klucher KM, Daley GQ, Kraeft SK, Sackstein R, Alyea EP, von Andrian UH, Chen LB, Gutierrez-Ramos JC, Pendergast AM, Griffin JD. The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha. Blood. 1999 Dec 15; 94(12):4233-46. PMID: 10590068.
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  84. Colby C, McAfee S, Sackstein R, Finkelstein D, Fishman J, Spitzer T. A prospective randomized trial comparing the toxicity and safety of atovaquone with trimethoprim/sulfamethoxazole as Pneumocystis carinii pneumonia prophylaxis following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1999 Oct; 24(8):897-902. PMID: 10516703.
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  85. Toh HC, McAfee SL, Sackstein R, Cox BF, Colby C, Spitzer TR. Late onset veno-occlusive disease following high-dose chemotherapy and stem cell transplantation. Bone Marrow Transplant. 1999 Oct; 24(8):891-5. PMID: 10516702.
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  86. Spitzer TR, Delmonico F, Tolkoff-Rubin N, McAfee S, Sackstein R, Saidman S, Colby C, Sykes M, Sachs DH, Cosimi AB. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation. 1999 Aug 27; 68(4):480-4. PMID: 10480403.
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  87. Sykes M, Preffer F, McAfee S, Saidman SL, Weymouth D, Andrews DM, Colby C, Sackstein R, Sachs DH, Spitzer TR. Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation. Lancet. 1999 May 22; 353(9166):1755-9. PMID: 10347989.
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  88. Ballester OF, Tummala R, Janssen WE, Fields KK, Hiemenz JW, Goldstein SC, Perkins JB, Sullivan DM, Rosen R, Sackstein R, Zorsky P, Saez R, Elfenbein GJ. High-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with multiple myeloma and renal insufficiency. Bone Marrow Transplant. 1997 Oct; 20(8):653-6. PMID: 9383228.
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  89. Sackstein R, Fu L, Allen KL. A hematopoietic cell L-selectin ligand exhibits sulfate-independent binding activity. Blood. 1997 Apr 15; 89(8):2773-81. PMID: 9108395.
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  90. Sackstein R. Expression of an L-selectin ligand on hematopoietic progenitor cells. Acta Haematol. 1997; 97(1-2):22-8. PMID: 8980607.
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  91. Wasik MA, Sackstein R, Novick D, Butmarc JR, Zhang Q, Vonderheid EC, Kadin ME. Cutaneous CD56+ large T-cell lymphoma associated with high serum concentration of IL-2. Hum Pathol. 1996 Jul; 27(7):738-44. PMID: 8698322.
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  92. Sackstein R. Lymphocyte migration following bone marrow transplantation. Ann N Y Acad Sci. 1995 Dec 29; 770:177-88. PMID: 8597359.
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  93. Sackstein R. Physiologic basis of steroid-induced immunosuppression. Effects on lymphocyte migration to lymph nodes. J Fla Med Assoc. 1995 Sep; 82(9):613-5. PMID: 7595343.
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  94. Sackstein R, Meng L, Xu XM, Chin YH. Evidence of post-transcriptional regulation of L-selectin gene expression in rat lymphoid cells. Immunology. 1995 Jun; 85(2):198-204. PMID: 7543874; PMCID: PMC1383881.
  95. Sackstein R, Borenstein M. The effects of corticosteroids on lymphocyte recirculation in humans: analysis of the mechanism of impaired lymphocyte migration to lymph node following methylprednisolone administration. J Investig Med. 1995 Feb; 43(1):68-77. PMID: 7719761.
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  96. Oxley SM, Sackstein R. Detection of an L-selectin ligand on a hematopoietic progenitor cell line. Blood. 1994 Nov 15; 84(10):3299-306. PMID: 7524735.
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  97. Sackstein R. Adoptive Immunotherapy: The Magic Bullet of Cancer Therapy? Cancer Control. 1994 Jan; 1(1):65-66. PMID: 10886954.
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  98. Sackstein R. Effects of methylprednisolone administration on lymphocyte LECAM-1, CD44, and LFA-1 expression. Implications for steroid-induced lymphopenia. Ann N Y Acad Sci. 1993 Nov 30; 696:417-9. PMID: 7509137.
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  99. Sackstein R. Physiologic migration of lymphocytes to lymph nodes following bone marrow transplantation: role in immune recovery. Semin Oncol. 1993 Oct; 20(5 Suppl 6):34-9. PMID: 7692606.
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  100. Chin YH, Sackstein R, Cai JP. Lymphocyte-homing receptors and preferential migration pathways. Proc Soc Exp Biol Med. 1991 Apr; 196(4):374-80. PMID: 2008438.
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  101. Chin YH, Falanga V, Streilein JW, Sackstein R. Lymphocyte recognition of psoriatic endothelium: evidence for a tissue-specific receptor/ligand interaction. J Invest Dermatol. 1989 Aug; 93(2 Suppl):82S-87S. PMID: 2546996.
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  102. Sackstein R, Falanga V, Streilein JW, Chin YH. Lymphocyte adhesion to psoriatic dermal endothelium is mediated by a tissue-specific receptor/ligand interaction. J Invest Dermatol. 1988 Nov; 91(5):423-8. PMID: 3262692.
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  103. Chin YH, Falanga V, Streilein JW, Sackstein R. Specific lymphocyte-endothelial cell interactions regulate migration into lymph nodes, Peyer's patches, and skin. Reg Immunol. 1988 Jul-Aug; 1(1):78-83. PMID: 3079311.
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  104. Whitehead AS, Sackstein R. Molecular biology of the human and mouse MHC class III genes: phylogenetic conservation, genetics and regulation of expression. Immunol Rev. 1985 Oct; 87:185-208. PMID: 3902622.
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  105. Sackstein R, Colten HR. Molecular regulation of MHC class III (C4 and factor B) gene expression in mouse peritoneal macrophages. J Immunol. 1984 Sep; 133(3):1618-26. PMID: 6205089.
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  106. Chaplin DD, Sackstein R, Perlmutter DH, Weis JH, Kruse TA, Coligan J, Colten HR, Seidman JG. Expression of hemolytically active murine fourth component of complement in transfected L cells. Cell. 1984 Jun; 37(2):569-76. PMID: 6327077.
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  107. Sackstein R, Roos MH, Démant P, Colten HR. Subdivision of the S region of the mouse major histocompatibility complex by identification of genomic polymorphisms of the class III genes. Immunogenetics. 1984; 20(3):321-30. PMID: 6088393.
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  108. Sackstein R, Colten HR, Woods DE. Phylogenetic conservation of a class III major histocompatibility complex antigen, factor B. Isolation and nucleotide sequencing of mouse factor B cDNA clones. J Biol Chem. 1983 Dec 10; 258(23):14693-7. PMID: 6689022.
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