Harvard Catalyst Profiles

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Wenyi Wei, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA200651 (WEI, WENYI) Jun 3, 2016 - May 31, 2021
    NIH/NCI
    Targeting the APC/Cdc20 E3 ubiquitin ligase for chemoradiation sensitization
    Role: Principal Investigator
  2. R01CA200573 (WEI, WENYI) Jun 1, 2016 - May 31, 2021
    NIH/NCI
    Characterizing the signaling pathways that regulate Skp2 oncogenic function
    Role: Principal Investigator
  3. R01CA177910 (TOKER, ALEX) Jul 16, 2013 - May 31, 2018
    NIH/NCI
    Novel regulation of PI3K/Akt to direct targeted breast cancer therapies
    Role: Co-Principal Investigator
  4. R01CA229307 (WEI, WENYI) May 1, 2012 - Feb 28, 2023
    NIH/NCI
    Functional analysis of a tissue context-dependent role for beta-TRCP in lipid metabolism and tumorigenesis
    Role: Principal Investigator
  5. R01GM094777 (WEI, WENYI) May 1, 2012 - Jan 31, 2016
    NIH/NIGMS
    Functional analysis of beta-TRCP in cell cycle control and DNA damage response
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 05 17; 364(6441). PMID: 31097636.
    Citations:    
  2. Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2019 May; 21(5):662-663. PMID: 30783264.
    Citations:    
  3. Kim W, Cho YS, Wang X, Park O, Ma X, Kim H, Gan W, Jho EH, Cha B, Jeung YJ, Zhang L, Gao B, Wei W, Jiang J, Chung KS, Yang Y. Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1. Proc Natl Acad Sci U S A. 2019 May 07; 116(19):9423-9432. PMID: 31000600.
    Citations:    
  4. Cheng J, Guo J, North BJ, Tao K, Zhou P, Wei W. The emerging role for Cullin 4 family of E3 ligases in tumorigenesis. Biochim Biophys Acta Rev Cancer. 2019 Jan; 1871(1):138-159. PMID: 30602127.
    Citations:    
  5. Zhang J, Chen M, Zhu Y, Dai X, Dang F, Ren J, Ren S, Shulga YV, Beca F, Gan W, Wu F, Lin YM, Zhou X, DeCaprio JA, Beck AH, Lu KP, Huang J, Zhao C, Sun Y, Gao X, Pandolfi PP, Wei W. SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. Dev Cell. 2019 Feb 11; 48(3):329-344.e5. PMID: 30595538.
    Citations:    Fields:    
  6. Zhang J, Dang F, Ren J, Wei W. Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy. Trends Biochem Sci. 2018 12; 43(12):1014-1032. PMID: 30287140.
    Citations:    Fields:    
  7. Liu P, Gan W, Su S, Hauenstein AV, Fu TM, Brasher B, Schwerdtfeger C, Liang AC, Xu M, Wei W. K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair. Sci Signal. 2018 Jun 05; 11(533). PMID: 29871913.
    Citations:    Fields:    
  8. Clement E, Inuzuka H, Nihira NT, Wei W, Toker A. Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors. Sci Signal. 2018 Mar 13; 11(521). PMID: 29535262.
    Citations:    Fields:    
  9. Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M, Hung MC, Wei W. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Mol Cell. 2018 01 18; 69(2):279-291.e5. PMID: 29351847.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  10. Chen M, Wan L, Zhang J, Zhang J, Mendez L, Clohessy JG, Berry K, Victor J, Yin Q, Zhu Y, Wei W, Pandolfi PP. Deregulated PP1a phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. Nat Commun. 2018 01 15; 9(1):159. PMID: 29335436.
    Citations:    Fields:    Translation:HumansCells
  11. Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira NT, Tan Y, Ci Y, Wu F, Dai X, Guo J, Huang YH, Fan C, Ren S, Sun Y, Freeman GJ, Sicinski P, Wei W. Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2018 01 04; 553(7686):91-95. PMID: 29160310.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  12. Cheng J, Guo J, Wang Z, North BJ, Tao K, Dai X, Wei W. Functional analysis of Cullin 3 E3 ligases in tumorigenesis. Biochim Biophys Acta Rev Cancer. 2018 Jan; 1869(1):11-28. PMID: 29128526.
    Citations: 1     Translation:HumansAnimalsCells
  13. Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nat Med. 2017 Sep; 23(9):1063-1071. PMID: 28805820.
    Citations: 18     Fields:    Translation:HumansCells
  14. Guo J, Cheng J, North BJ, Wei W. Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology. Biochim Biophys Acta Rev Cancer. 2017 Dec; 1868(2):341-358. PMID: 28694093.
    Citations: 5     Translation:HumansAnimalsCells
  15. Zhang J, Liu J, Wei W. "FEM1"nism controls SLBP stability during cell cycle. Cell Cycle. 2017 04 03; 16(7):597-598. PMID: 28324668.
    Citations:    Fields:    
  16. Nihira NT, Ogura K, Shimizu K, North BJ, Zhang J, Gao D, Inuzuka H, Wei W. Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Sci Signal. 2017 02 14; 10(466). PMID: 28196907.
    Citations: 4     Fields:    Translation:HumansCells
  17. Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kolodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, Gygi SP, Wei W, Sicinski P. G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Nat Cell Biol. 2017 03; 19(3):177-188. PMID: 28192421.
    Citations: 10     Fields:    Translation:AnimalsCells
  18. Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discov. 2017 04; 7(4):424-441. PMID: 28174173.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  19. Zhang L, Peng S, Dai X, Gan W, Nie X, Wei W, Hu G, Guo J. Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells. Cancer Lett. 2017 04 01; 390:11-20. PMID: 28089830.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  20. Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W. The SCFß-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Sci Signal. 2017 01 03; 10(460). PMID: 28049764.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  21. Dai X, Wang Z, Wei W. SPOP-mediated degradation of BRD4 dictates cellular sensitivity to BET inhibitors. Cell Cycle. 2017; 16(24):2326-2329. PMID: 29108467.
    Citations: 2     Fields:    
  22. Wu F, Dai X, Gan W, Wan L, Li M, Mitsiades N, Wei W, Ding Q, Zhang J. Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation. Cancer Lett. 2017 01 28; 385:207-214. PMID: 27780719.
    Citations: 5     Fields:    Translation:HumansCells
  23. Cheng J, Zhang T, Ji H, Tao K, Guo J, Wei W. Functional characterization of AMP-activated protein kinase signaling in tumorigenesis. Biochim Biophys Acta. 2016 12; 1866(2):232-251. PMID: 27681874.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  24. Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, Asara JM, Kaelin WG, Wei W. pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science. 2016 08 26; 353(6302):929-32. PMID: 27563096.
    Citations: 21     Fields:    Translation:HumansCells
  25. Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Mol Cell. 2016 06 16; 62(6):929-942. PMID: 27237051.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  26. Liu J, Wan L, Liu J, Yuan Z, Zhang J, Guo J, Malumbres M, Liu J, Zou W, Wei W. Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discov. 2016; 2:15044. PMID: 27462441.
    Citations: 4     
  27. Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W. SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. Mol Cell. 2015 Sep 17; 59(6):917-30. PMID: 26344095.
    Citations: 40     Fields:    Translation:HumansCells
  28. Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discov. 2015 Nov; 5(11):1194-209. PMID: 26293922.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  29. Gan W, Liu P, Wei W. Akt promotes tumorigenesis in part through modulating genomic instability via phosphorylating XLF. Nucleus. 2015; 6(4):261-5. PMID: 26225792.
    Citations: 3     Fields:    Translation:HumansCells
  30. Gan W, Liu P, Wei W. Cell cycle status dictates effectiveness of rapamycin. Cell Cycle. 2015; 14(16):2556-7. PMID: 26126171.
    Citations: 2     Fields:    Translation:Humans
  31. Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W. Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair. Mol Cell. 2015 Feb 19; 57(4):648-661. PMID: 25661488.
    Citations: 14     Fields:    Translation:HumansCells
  32. Liu J, Shaik S, Dai X, Wu Q, Zhou X, Wang Z, Wei W. Targeting the ubiquitin pathway for cancer treatment. Biochim Biophys Acta. 2015 Jan; 1855(1):50-60. PMID: 25481052.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  33. Xu K, Liu P, Wei W. mTOR signaling in tumorigenesis. Biochim Biophys Acta. 2014 Dec; 1846(2):638-54. PMID: 25450580.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  34. Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol Cell. 2014 Nov 20; 56(4):595-607. PMID: 25458846.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  35. Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC, Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT, Sicinski P. Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014 Nov; 16(11):1080-91. PMID: 25344755.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  36. Wu X, Fukushima H, North BJ, Nagaoka Y, Nagashima K, Deng F, Okabe K, Inuzuka H, Wei W. SCFß-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination. Oncotarget. 2014 Jun 30; 5(12):4211-21. PMID: 24961988.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  37. Liu P, Wang Z, Wei W. Phosphorylation of Akt at the C-terminal tail triggers Akt activation. Cell Cycle. 2014; 13(14):2162-4. PMID: 24933731.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  38. Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Dev Cell. 2014 May 27; 29(4):377-91. PMID: 24871945.
    Citations: 27     Fields:    Translation:HumansCells
  39. Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, Pinton P, Bronson RT, Wei W, Pandolfi PP. Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell. 2014 Apr 24; 157(3):595-610. PMID: 24766807.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  40. Yu G, Gail MH, Shi J, Klepac-Ceraj V, Paster BJ, Dye BA, Wang GQ, Wei WQ, Fan JH, Qiao YL, Dawsey SM, Freedman ND, Abnet CC. Association between upper digestive tract microbiota and cancer-predisposing states in the esophagus and stomach. Cancer Epidemiol Biomarkers Prev. 2014 May; 23(5):735-41. PMID: 24700175.
    Citations: 21     Fields:    Translation:Humans
  41. Wang Z, Liu P, Inuzuka H, Wei W. Roles of F-box proteins in cancer. Nat Rev Cancer. 2014 Apr; 14(4):233-47. PMID: 24658274.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  42. Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24; 508(7497):541-5. PMID: 24670654.
    Citations: 84     Fields:    Translation:AnimalsCells
  43. Liu P, Guo J, Gan W, Wei W. Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity. Protein Cell. 2014 Mar; 5(3):171-7. PMID: 24481632.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  44. Zhang J, Wan L, Dai X, Sun Y, Wei W. Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis. Biochim Biophys Acta. 2014 Apr; 1845(2):277-93. PMID: 24569229.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  45. Zhong J, Shaik S, Wan L, Tron AE, Wang Z, Sun L, Inuzuka H, Wei W. SCF ß-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration. Oncotarget. 2013 Dec; 4(12):2339-53. PMID: 24318128.
    Citations: 20     Fields:    Translation:HumansCells
  46. Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2013 Nov; 15(11):1340-50. PMID: 24161930.
    Citations: 76     Fields:    Translation:HumansCells
  47. Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep. 2013 Aug 29; 4(4):803-16. PMID: 23972993.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  48. Lau AW, Inuzuka H, Fukushima H, Wan L, Liu P, Gao D, Sun Y, Wei W. Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. Cell Res. 2013 Jul; 23(7):947-61. PMID: 23670162.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  49. Wang Z, Wan L, Zhong J, Inuzuka H, Liu P, Sarkar FH, Wei W. Cdc20: a potential novel therapeutic target for cancer treatment. Curr Pharm Des. 2013; 19(18):3210-4. PMID: 23151139.
    Citations: 17     Fields:    Translation:HumansAnimals
  50. Wei W, Lin HK. The key role of ubiquitination and sumoylation in signaling and cancer: a research topic. Front Oncol. 2012; 2:187. PMID: 23227454.
    Citations: 4     
  51. Wang Z, Inuzuka H, Zhong J, Liu P, Sarkar FH, Sun Y, Wei W. Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. Oncotarget. 2012 Nov; 3(11):1294-300. PMID: 23230084.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  52. Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, Wei W. DNA damage-induced activation of ATM promotes ß-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 2012 Sep; 3(9):1026-35. PMID: 22976441.
    Citations: 10     Fields:    Translation:HumansCells
  53. Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 06; 150(1):179-93. PMID: 22770219.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  54. Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. SCF(ß-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J Exp Med. 2012 Jul 02; 209(7):1289-307. PMID: 22711876.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  55. Wang Z, Wei W, Sarkar FH. miR-23a, a critical regulator of "migR"ation and metastasis in colorectal cancer. Cancer Discov. 2012 Jun; 2(6):489-91. PMID: 22684455.
    Citations: 14     Fields:    Translation:HumansAnimals
  56. Lau AW, Fukushima H, Wei W. The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis. Front Biosci (Landmark Ed). 2012 Jun 01; 17:2197-212. PMID: 22652772.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  57. Fukushima H, Matsumoto A, Inuzuka H, Zhai B, Lau AW, Wan L, Gao D, Shaik S, Yuan M, Gygi SP, Jimi E, Asara JM, Nakayama K, Nakayama KI, Wei W. SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction. Cell Rep. 2012 May 31; 1(5):434-43. PMID: 22708077.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  58. Min SH, Lau AW, Lee TH, Inuzuka H, Wei S, Huang P, Shaik S, Lee DY, Finn G, Balastik M, Chen CH, Luo M, Tron AE, Decaprio JA, Zhou XZ, Wei W, Lu KP. Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol Cell. 2012 Jun 29; 46(6):771-83. PMID: 22608923.
    Citations: 50     Fields:    Translation:HumansCells
  59. Wang Z, Zhong J, Inuzuka H, Gao D, Shaik S, Sarkar FH, Wei W. An evolving role for DEPTOR in tumor development and progression. Neoplasia. 2012 May; 14(5):368-75. PMID: 22745583.
    Citations: 21     Fields:    Translation:HumansCells
  60. Wang Z, Zhong J, Gao D, Inuzuka H, Liu P, Wei W. DEPTOR ubiquitination and destruction by SCF(ß-TrCP). Am J Physiol Endocrinol Metab. 2012 Jul 15; 303(2):E163-9. PMID: 22454292.
    Citations: 4     Fields:    Translation:HumansCells
  61. Wang Z, Inuzuka H, Zhong J, Wan L, Fukushima H, Sarkar FH, Wei W. Tumor suppressor functions of FBW7 in cancer development and progression. FEBS Lett. 2012 May 21; 586(10):1409-18. PMID: 22673505.
    Citations: 61     Fields:    Translation:HumansAnimals
  62. Wang G, Wang Z, Sarkar FH, Wei W. Targeting prostate cancer stem cells for cancer therapy. Discov Med. 2012 Feb; 13(69):135-42. PMID: 22369972.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  63. Wang Z, Fukushima H, Inuzuka H, Wan L, Liu P, Gao D, Sarkar FH, Wei W. Skp2 is a promising therapeutic target in breast cancer. Front Oncol. 2012 Jan 04; 1(57). PMID: 22279619.
    Citations: 27     
  64. Wang Z, Inuzuka H, Fukushima H, Wan L, Gao D, Shaik S, Sarkar FH, Wei W. Emerging roles of the FBW7 tumour suppressor in stem cell differentiation. EMBO Rep. 2011 Dec 23; 13(1):36-43. PMID: 22157894.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  65. Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH, Wei W. Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell. 2011 Dec 09; 44(5):721-33. PMID: 22152476.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  66. Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW, Wei W. mTOR drives its own activation via SCF(ßTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell. 2011 Oct 21; 44(2):290-303. PMID: 22017875.
    Citations: 85     Fields:    Translation:HumansCells
  67. Wang Z, Gao D, Fukushima H, Inuzuka H, Liu P, Wan L, Sarkar FH, Wei W. Skp2: a novel potential therapeutic target for prostate cancer. Biochim Biophys Acta. 2012 Jan; 1825(1):11-7. PMID: 21963805.
    Citations: 40     Fields:    Translation:HumansCells
  68. Wang Z, Fukushima H, Gao D, Inuzuka H, Wan L, Lau AW, Liu P, Wei W. The two faces of FBW7 in cancer drug resistance. Bioessays. 2011 Nov; 33(11):851-9. PMID: 22006825.
    Citations: 22     Fields:    Translation:HumansCells
  69. Wei W, Kaelin WG. Good COP1 or bad COP1? In vivo veritas. J Clin Invest. 2011 Apr; 121(4):1263-5. PMID: 21403396.
    Citations: 11     Fields:    Translation:HumansAnimals
  70. Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 2011 Mar 03; 471(7336):104-9. PMID: 21368833.
    Citations: 209     Fields:    Translation:HumansAnimalsCells
  71. Inuzuka H, Fukushima H, Shaik S, Liu P, Lau AW, Wei W. Mcl-1 ubiquitination and destruction. Oncotarget. 2011 Mar; 2(3):239-44. PMID: 21608150.
    Citations: 39     Fields:    Translation:HumansCells
  72. Inuzuka H, Fukushima H, Shaik S, Wei W. Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction. Oncotarget. 2010 Nov; 1(7):685-90. PMID: 21317463.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  73. Gao D, Wan L, Wei W. Phosphorylation of Rictor at Thr1135 impairs the Rictor/Cullin-1 complex to ubiquitinate SGK1. Protein Cell. 2010 Oct; 1(10):881-5. PMID: 21204013.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  74. Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10; 39(5):797-808. PMID: 20832730.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  75. Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG, Harper JW, Wei W. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 2010 Aug 09; 18(2):147-59. PMID: 20708156.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  76. Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell. 2010 Mar 15; 21(6):1140-52. PMID: 20110348.
    Citations: 38     Fields:    Translation:HumansCells
  77. Gao D, Inuzuka H, Tseng A, Wei W. Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1. Cell Div. 2009 Jun 23; 4:11. PMID: 19549334.
    Citations: 12     
  78. Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N, Wei W. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell. 2009 Jul; 20(14):3305-16. PMID: 19477924.
    Citations: 30     Fields:    Translation:HumansCells
  79. Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol. 2009 Apr; 11(4):397-408. PMID: 19270695.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  80. Tseng A, Inuzuka H, Gao D, Singh A, Wei W. Experimental approaches to investigate the proteasomal degradation pathways involved in regulation of apoptosis. Methods Enzymol. 2008; 446:205-23. PMID: 18603124.
    Citations:    Fields:    Translation:HumansCells
  81. Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG, Näär AM, Dyson NJ. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat Cell Biol. 2007 Feb; 9(2):225-32. PMID: 17187060.
    Citations: 83     Fields:    Translation:HumansCells
  82. Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell. 2005 Aug; 8(2):155-67. PMID: 16098468.
    Citations: 148     Fields:    Translation:HumansCells
  83. Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell. 2005 Jul; 8(1):25-33. PMID: 16023596.
    Citations: 153     Fields:    Translation:HumansCells
  84. Yuan ZL, Guan YJ, Wang L, Wei W, Kane AB, Chin YE. Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol. 2004 Nov; 24(21):9390-400. PMID: 15485908.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  85. Zhang GJ, Safran M, Wei W, Sorensen E, Lassota P, Zhelev N, Neuberg DS, Shapiro G, Kaelin WG. Bioluminescent imaging of Cdk2 inhibition in vivo. Nat Med. 2004 Jun; 10(6):643-8. PMID: 15122251.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  86. Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature. 2004 Mar 11; 428(6979):194-8. PMID: 15014503.
    Citations: 173     Fields:    Translation:HumansAnimalsCells
  87. Martin-Ruiz C, Saretzki G, Petrie J, Ladhoff J, Jeyapalan J, Wei W, Sedivy J, von Zglinicki T. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J Biol Chem. 2004 Apr 23; 279(17):17826-33. PMID: 14963037.
    Citations: 26     Fields:    Translation:HumansCells
  88. Herbig U, Wei W, Dutriaux A, Jobling WA, Sedivy JM. Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence. Aging Cell. 2003 12; 2(6):295-304. PMID: 14677632.
    Citations: 9     Fields:    Translation:HumansCells
  89. Wei W, Herbig U, Wei S, Dutriaux A, Sedivy JM. Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts. EMBO Rep. 2003 Nov; 4(11):1061-6. PMID: 14566323.
    Citations: 22     Fields:    Translation:HumansCells
  90. Wei W, Jobling WA, Chen W, Hahn WC, Sedivy JM. Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Mol Cell Biol. 2003 Apr; 23(8):2859-70. PMID: 12665584.
    Citations: 24     Fields:    Translation:HumansCells
  91. Han Z, Wei W, Dunaway S, Darnowski JW, Calabresi P, Sedivy J, Hendrickson EA, Balan KV, Pantazis P, Wyche JH. Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. J Biol Chem. 2002 May 10; 277(19):17154-60. PMID: 11877436.
    Citations: 48     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.