Harvard Catalyst Profiles

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David Stuart Auld, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM053265 (AULD, DAVID S) Jan 1, 1995 - Dec 31, 1998
    Role: Principal Investigator
  2. R01GM047534 (AULD, DAVID S) Aug 1, 1992 - Jul 31, 1996
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Auld DS. The ins and outs of biological zinc sites. Biometals. 2009 Feb; 22(1):141-8. PMID: 19140015.
    Citations: 11     Fields:    Translation:HumansCells
  2. Bergman T, Zhang K, Palmberg C, Jörnvall H, Auld DS. Zinc binding to peptide analogs of the structural zinc site in alcohol dehydrogenase: implications for an entatic state. Cell Mol Life Sci. 2008 Dec; 65(24):4019-27. PMID: 18850316.
    Citations: 3     Fields:    Translation:AnimalsCells
  3. Chong CR, Auld DS. Catalysis of zinc transfer by D-penicillamine to secondary chelators. J Med Chem. 2007 Nov 01; 50(22):5524-7. PMID: 17918925.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Zhang K, Liu R, Irving T, Auld DS. A versatile rapid-mixing and flow device for X-ray absorption spectroscopy. J Synchrotron Radiat. 2004 Mar 01; 11(Pt 2):204-8. PMID: 14960787.
    Citations: 1     Fields:    Translation:Cells
  5. Auld DS. Zinc coordination sphere in biochemical zinc sites. Biometals. 2001 Sep-Dec; 14(3-4):271-313. PMID: 11831461.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  6. Groche D, Rashkovetsky LG, Falchuk KH, Auld DS. Subunit composition of the zinc proteins alpha- and beta-lipovitellin from chicken. J Protein Chem. 2000 Jul; 19(5):379-87. PMID: 11131145.
    Citations: 2     Fields:    Translation:Animals
  7. Chong CR, Auld DS. Inhibition of carboxypeptidase A by D-penicillamine: mechanism and implications for drug design. Biochemistry. 2000 Jun 27; 39(25):7580-8. PMID: 10858308.
    Citations: 2     Fields:    Translation:Cells
  8. Bergman T, Palmberg C, Jörnvall H, Auld DS, Vallee BL. Zinc binding characteristics of the synthetic peptide corresponding to the structural zinc site of horse liver alcohol dehydrogenase. Adv Exp Med Biol. 1999; 463:339-42. PMID: 10352703.
    Citations:    Fields:    Translation:AnimalsCells
  9. Cha J, Auld DS. Site-directed mutagenesis of the active site glutamate in human matrilysin: investigation of its role in catalysis. Biochemistry. 1997 Dec 16; 36(50):16019-24. PMID: 9398337.
    Citations: 12     Fields:    Translation:HumansCells
  10. Cha J, Pedersen MV, Auld DS. Metal and pH dependence of heptapeptide catalysis by human matrilysin. Biochemistry. 1996 Dec 10; 35(49):15831-8. PMID: 8961947.
    Citations: 8     Fields:    Translation:HumansCells
  11. Auld DS, Falchuk KH, Zhang K, Montorzi M, Vallee BL. X-ray absorption fine structure as a monitor of zinc coordination sites during oogenesis of Xenopus laevis. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3227-31. PMID: 8622918.
    Citations:    Fields:    Translation:AnimalsCells
  12. Soler D, Nomizu T, Brown WE, Shibata Y, Auld DS. Matrilysin: expression, purification, and characterization. J Protein Chem. 1995 Oct; 14(7):511-20. PMID: 8561847.
    Citations: 2     Fields:    Translation:HumansCells
  13. Auld DS. Removal and replacement of metal ions in metallopeptidases. Methods Enzymol. 1995; 248:228-42. PMID: 7674923.
    Citations: 17     Fields:    
  14. Vallee BL, Auld DS. Zinc metallochemistry in biochemistry. EXS. 1995; 73:259-77. PMID: 7579976.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  15. Soler D, Nomizu T, Brown WE, Chen M, Ye QZ, Van Wart HE, Auld DS. Zinc content of promatrilysin, matrilysin and the stromelysin catalytic domain. Biochem Biophys Res Commun. 1994 Jun 15; 201(2):917-23. PMID: 8003031.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  16. Zhang K, Auld DS. XAFS studies of carboxypeptidase A: detection of a structural alteration in the zinc coordination sphere coupled to the catalytically important alkaline pKa. Biochemistry. 1993 Dec 21; 32(50):13844-51. PMID: 8268159.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Vallee BL, Auld DS. New perspective on zinc biochemistry: cocatalytic sites in multi-zinc enzymes. Biochemistry. 1993 Jul 06; 32(26):6493-500. PMID: 8329379.
    Citations: 26     Fields:    Translation:AnimalsCells
  18. Vallee BL, Auld DS. Cocatalytic zinc motifs in enzyme catalysis. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):2715-8. PMID: 8464881.
    Citations: 24     Fields:    Translation:AnimalsCells
  19. Auld DS. Low-temperature stopped-flow rapid-scanning spectroscopy: performance tests and use of aqueous salt cryosolvents. Methods Enzymol. 1993; 226:553-65. PMID: 8277882.
    Citations: 2     Fields:    Translation:Cells
  20. Auld DS, Bertini I, Donaire A, Messori L, Moratal JM. pH-dependent properties of cobalt(II) carboxypeptidase A-inhibitor complexes. Biochemistry. 1992 Apr 21; 31(15):3840-6. PMID: 1567840.
    Citations:    Fields:    Translation:Animals
  21. Vallee BL, Auld DS. Active zinc binding sites of zinc metalloenzymes. Matrix Suppl. 1992; 1:5-19. PMID: 1480086.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  22. Vallee BL, Auld DS. Functional zinc-binding motifs in enzymes and DNA-binding proteins. Faraday Discuss. 1992; (93):47-65. PMID: 1290939.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  23. Larsen KS, Auld DS. Characterization of an inhibitory metal binding site in carboxypeptidase A. Biochemistry. 1991 Mar 12; 30(10):2613-8. PMID: 2001351.
    Citations: 18     Fields:    Translation:AnimalsCells
  24. Vallee BL, Coleman JE, Auld DS. Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains. Proc Natl Acad Sci U S A. 1991 Feb 01; 88(3):999-1003. PMID: 1846973.
    Citations: 65     Fields:    Translation:AnimalsCells
  25. Vallee BL, Auld DS. Zinc coordination, function, and structure of zinc enzymes and other proteins. Biochemistry. 1990 Jun 19; 29(24):5647-59. PMID: 2200508.
    Citations: 246     Fields:    Translation:HumansAnimalsCells
  26. Vallee BL, Auld DS. Active-site zinc ligands and activated H2O of zinc enzymes. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):220-4. PMID: 2104979.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  27. Larsen KS, Auld DS. Carboxypeptidase A: mechanism of zinc inhibition. Biochemistry. 1989 Dec 12; 28(25):9620-5. PMID: 2611251.
    Citations: 9     Fields:    Translation:Animals
  28. Ng M, Auld DS. A fluorescent oligopeptide energy transfer assay with broad applications for neutral proteases. Anal Biochem. 1989 Nov 15; 183(1):50-6. PMID: 2559628.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  29. Vallee BL, Auld DS. Short and long spacer sequences and other structural features of zinc binding sites in zinc enzymes. FEBS Lett. 1989 Oct 23; 257(1):138-40. PMID: 2572457.
    Citations: 11     Fields:    Translation:Cells
  30. Rybak SM, Auld DS, St Clair DK, Yao QZ, Fett JW. C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin. Biochem Biophys Res Commun. 1989 Jul 14; 162(1):535-43. PMID: 2473749.
    Citations: 2     Fields:    Translation:AnimalsCells
  31. Briganti F, Fong WP, Auld DS, Vallee BL. In vitro dissociation and reassociation of human alcohol dehydrogenase class I isozymes. Biochemistry. 1989 Jun 27; 28(13):5374-9. PMID: 2775712.
    Citations: 1     Fields:    Translation:HumansCells
  32. Martinelli RA, Hanson GR, Thompson JS, Holmquist B, Pilbrow JR, Auld DS, Vallee BL. Characterization of the inhibitor complexes of cobalt carboxypeptidase A by electron paramagnetic resonance spectroscopy. Biochemistry. 1989 Mar 07; 28(5):2251-8. PMID: 2541781.
    Citations: 4     Fields:    Translation:Cells
  33. Lee FS, Auld DS, Vallee BL. Tryptophan fluorescence as a probe of placental ribonuclease inhibitor binding to angiogenin. Biochemistry. 1989 Jan 10; 28(1):219-24. PMID: 2706245.
    Citations: 14     Fields:    Translation:Humans
  34. Tosteson MT, Auld DS, Tosteson DC. Voltage-gated channels formed in lipid bilayers by a positively charged segment of the Na-channel polypeptide. Proc Natl Acad Sci U S A. 1989 Jan; 86(2):707-10. PMID: 2536173.
    Citations: 20     Fields:    
  35. McEvily AJ, Holmquist B, Auld DS, Vallee BL. 3 beta-Hydroxy-5 beta-steroid dehydrogenase activity of human liver alcohol dehydrogenase is specific to gamma-subunits. Biochemistry. 1988 Jun 14; 27(12):4284-8. PMID: 3166980.
    Citations: 3     Fields:    Translation:Humans
  36. Maret W, Auld DS. Purification and characterization of human liver sorbitol dehydrogenase. Biochemistry. 1988 Mar 08; 27(5):1622-8. PMID: 3365415.
    Citations: 8     Fields:    Translation:HumansAnimals
  37. Bicknell R, Schäffer A, Bertini I, Luchinat C, Vallee BL, Auld DS. Interaction of anions with the active site of carboxypeptidase A. Biochemistry. 1988 Feb 09; 27(3):1050-7. PMID: 2835074.
    Citations: 1     Fields:    Translation:Cells
  38. Harper JW, Auld DS, Riordan JF, Vallee BL. Enzymatically active angiogenin/ribonuclease A hybrids formed by peptide interchange. Biochemistry. 1988 Jan 12; 27(1):219-26. PMID: 3349027.
    Citations: 3     Fields:    Translation:HumansCells
  39. Mårdh G, Auld DS, Vallee BL. Thyroid hormones selectively modulate human alcohol dehydrogenase isozyme catalyzed ethanol oxidation. Biochemistry. 1987 Dec 01; 26(24):7585-8. PMID: 3427094.
    Citations:    Fields:    Translation:HumansCells
  40. Mårdh G, Falchuk KH, Auld DS, Vallee BL. Testosterone allosterically regulates ethanol oxidation by homo- and heterodimeric gamma-subunit-containing isozymes of human alcohol dehydrogenase. Proc Natl Acad Sci U S A. 1986 May; 83(9):2836-40. PMID: 2939458.
    Citations: 3     Fields:    Translation:HumansCells
  41. Dasgupta D, Auld DS, Goldberg IH. Cryospectrokinetic evidence for the mode of reversible binding of neocarzinostatin chromophore to poly(deoxyadenylic-thymidylic acid). Biochemistry. 1985 Dec 03; 24(25):7049-54. PMID: 2935186.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.