Harvard Catalyst Profiles

I am a cardiologist at Brigham and Women’s Hospital and Professor of Medicine at Harvard Medical School. I also serve as Executive Director of Cardiometabolic Trials at the Baim Institute of Clinical Research. Over the past 27 years, I have been the principal investigator of more than 18 multicenter clinical trials including TACTICS-TIMI 18, PROVE IT-TIMI 22, IMPROVE IT and currently the RE-DUAL PCI trial.  My research has focused on management and prevention of acute coronary syndromes (ACS) with a goal of trying to directly improve patient care. Collaborating with others, we have helped establish various antithrombotic and interventional strategies for ACS, as well as long-term lipid management approaches for prevention that are included in current international guidelines. More recently, I am also studying prevention approaches in diabetes and in atrial fibrillation. Finally, I help lead registries and quality improvement educational initiatives with an aim toward implementation of research advances in clinical practice.