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Jaehong Suh, Ph.D.

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Dr. Jaehong Suh studies the genetic and molecular mechanisms of Alzheimer’s disease (AD) and other neurodegenerative disorders, with the aim of identifying novel therapeutic targets and developing effective treatments for patients. Suh was involved in the identification of novel mutations from late-onset AD families in the prodomain of ADAM10, a major alpha-secretase that cleaves beta-amyloid (Abeta) region of amyloid precursor protein (APP). Subsequently, Suh and his colleagues generated a mouse model with the same mutations and showed that the ADAM10 mutations attenuate alpha-secretase activity of the enzyme, potentiate the accumulation of Abeta and decrease the generation of new neurons in the brain. Suh and his lab continue to characterize additional ADAM10 mutations, and identify novel ADAM10 substrates in the brain. Additionally, Suh is pursing mechanistic studies on another AD-associated gene, Ataxin-1, which was found recently in a genetic screen of AD families. Expansion of CAG trinucleotide repeat in Ataxin-1 gene is known to cause spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disease that primarily impairs coordinated movement. At MGH, Suh has also studied the role of FE65 and FE65L1 APP-binding proteins on APP processing in neurons and identified abnormal eye and muscle phenotypes in the knockout mice for the two genes.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG056775 (SUH, JAEHONG) Aug 15, 2018 - Apr 30, 2023
    Role of Ataxin-1 in BACE1 Expression and Alzheimer's Disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Pagire SH, Pagire HS, Park KY, Bae EJ, Kim KE, Kim M, Yoon J, Parameswaran S, Choi JH, Park S, Jeon JH, Song JS, Bae MA, Lee IK, Kim H, Suh JM, Ahn JH. Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease. Molecules. 2022 May 25; 27(11). PMID: 35684355; PMCID: PMC9182086.
    Citations:    Fields:    Translation:Animals
  2. Choi WG, Choi W, Oh TJ, Cha HN, Hwang I, Lee YK, Lee SY, Shin H, Lim A, Ryu D, Suh JM, Park SY, Choi SH, Kim H. Inhibiting serotonin signaling through HTR2B in visceral adipose tissue improves obesity-related insulin resistance. J Clin Invest. 2021 12 01; 131(23). PMID: 34618686; PMCID: PMC8631597.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  3. Park SJ, Kim H, Shin K, Hong TH, Suh JH, Lee MA. Nanoliposomal irinotecan plus fluorouracil and folinic acid as a second-line treatment option in patients with metastatic pancreatic ductal adenocarcinoma: a retrospective cohort study. BMC Cancer. 2021 Nov 03; 21(1):1176. PMID: 34732161; PMCID: PMC8567553.
    Citations:    Fields:    Translation:Humans
  4. Kang SG, Choi MJ, Jung SB, Chung HK, Chang JY, Kim JT, Kang YE, Lee JH, Hong HJ, Jun SM, Ro HJ, Suh JM, Kim H, Auwerx J, Yi HS, Shong M. Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response. iScience. 2021 Mar 19; 24(3):102181. PMID: 33718833.
    Citations: 8     
  5. Lee JH, Suh JH, Kang HJ, Choi SY, Jung SW, Lee-Kwon W, Park SA, Kim H, Ye BJ, Yoo EJ, Jeong GW, Park NH, Kwon HM. Tonicity-responsive enhancer-binding protein promotes stemness of liver cancer and cisplatin resistance. EBioMedicine. 2020 Aug; 58:102926. PMID: 32739873.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  6. Son MJ, Oh KJ, Park A, Kwon MG, Suh JM, Kim IC, Kim S, Lee SC, Kim WK, Bae KH. GATA3 induces the upregulation of UCP-1 by directly binding to PGC-1a during adipose tissue browning. Metabolism. 2020 08; 109:154280. PMID: 32473155.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Kang HS, Lee JH, Oh KJ, Lee EW, Han BS, Park KY, Suh JM, Min JK, Chi SW, Lee SC, Bae KH, Kim WK. IDH1-dependent a-KG regulates brown fat differentiation and function by modulating histone methylation. Metabolism. 2020 04; 105:154173. PMID: 32035087.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Kim H, Yoon BH, Oh CM, Lee J, Lee K, Song H, Kim E, Yi K, Kim MY, Kim H, Kim YK, Seo EH, Heo H, Kim HJ, Lee J, Suh JM, Koo SH, Seong JK, Kim S, Ju YS, Shong M, Kim M, Kim H. PRMT1 Is Required for the Maintenance of Mature ß-Cell Identity. Diabetes. 2020 03; 69(3):355-368. PMID: 31848151.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, Zoghbi HY, Tanzi RE. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019 08 22; 178(5):1159-1175.e17. PMID: 31442405; PMCID: PMC6726125.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  10. Choi W, Namkung J, Hwang I, Kim H, Lim A, Park HJ, Lee HW, Han KH, Park S, Jeong JS, Bang G, Kim YH, Yadav VK, Karsenty G, Ju YS, Choi C, Suh JM, Park JY, Park S, Kim H. Publisher Correction: Serotonin signals through a gut-liver axis to regulate hepatic steatosis. Nat Commun. 2019 01 08; 10(1):158. PMID: 30622275.
    Citations: 1     Fields:    
  11. Choi W, Namkung J, Hwang I, Kim H, Lim A, Park HJ, Lee HW, Han KH, Park S, Jeong JS, Bang G, Kim YH, Yadav VK, Karsenty G, Ju YS, Choi C, Suh JM, Park JY, Park S, Kim H. Serotonin signals through a gut-liver axis to regulate hepatic steatosis. Nat Commun. 2018 11 16; 9(1):4824. PMID: 30446669.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  12. Lee JH, Suh JH, Choi SY, Kang HJ, Lee HH, Ye BJ, Lee GR, Jung SW, Kim CJ, Lee-Kwon W, Park J, Myung K, Park NH, Kwon HM. Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis. Gut. 2019 02; 68(2):347-358. PMID: 29420225; PMCID: PMC6352413.
    Citations: 16     Fields:    Translation:HumansAnimals
  13. Ke K, Sul OJ, Chung SW, Suh JH, Choi HS. Lack of NOD2 attenuates ovariectomy-induced bone loss via inhibition of osteoclasts. J Endocrinol. 2017 Nov; 235(2):85-96. PMID: 28778866.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. Ke K, Safder MA, Sul OJ, Kim WK, Suh JH, Joe Y, Chung HT, Choi HS. Hemeoxygenase-1 maintains bone mass via attenuating a redox imbalance in osteoclast. Mol Cell Endocrinol. 2015 Jul 05; 409:11-20. PMID: 25841764.
    Citations: 15     Fields:    Translation:AnimalsCells
  15. Suh J, Moncaster JA, Wang L, Hafeez I, Herz J, Tanzi RE, Goldstein LE, Guénette SY. FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness. FASEB J. 2015 Jun; 29(6):2628-39. PMID: 25757569; PMCID: PMC4447227.
    Citations: 5     Fields:    Translation:AnimalsCells
  16. Nensa FM, Neumann MH, Schrötter A, Przyborski A, Mastalski T, Susdalzew S, Looße C, Helling S, El Magraoui F, Erdmann R, Meyer HE, Uszkoreit J, Eisenacher M, Suh J, Guénette SY, Röhner N, Kögel D, Theiss C, Marcus K, Müller T. Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain. Mol Cell Proteomics. 2014 Feb; 13(2):475-88. PMID: 24284412.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  17. Suh J, Choi SH, Romano DM, Gannon MA, Lesinski AN, Kim DY, Tanzi RE. ADAM10 missense mutations potentiate ß-amyloid accumulation by impairing prodomain chaperone function. Neuron. 2013 Oct 16; 80(2):385-401. PMID: 24055016.
    Citations: 87     Fields:    Translation:HumansAnimals
  18. Suh J, Lyckman A, Wang L, Eckman EA, Guénette SY. FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing. J Neurochem. 2011 Oct; 119(2):377-88. PMID: 21824144.
    Citations: 10     Fields:    Translation:AnimalsCells
  19. Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ, Gwag BJ. Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice. Exp Mol Med. 2010 May 31; 42(5):386-94. PMID: 20368688; PMCID: PMC2877248.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  20. Suh J, Im DS, Moon GJ, Ryu KS, de Silva R, Choi IS, Lees AJ, Guénette SY, Tanzi RE, Gwag BJ. Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing. J Neurochem. 2010 Jul; 114(1):160-70. PMID: 20374429.
    Citations: 7     Fields:    Translation:AnimalsCells
  21. Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet. 2009 Oct 15; 18(20):3987-96. PMID: 19608551.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  22. Lee JK, Shin JH, Suh J, Choi IS, Ryu KS, Gwag BJ. Tissue inhibitor of metalloproteinases-3 (TIMP-3) expression is increased during serum deprivation-induced neuronal apoptosis in vitro and in the G93A mouse model of amyotrophic lateral sclerosis: a potential modulator of Fas-mediated apoptosis. Neurobiol Dis. 2008 May; 30(2):174-85. PMID: 18316197.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  23. Cho HR, Suh JH, Lee EA, Kim JE, Lee SC, Kwon B. Improved surgical technique for heterotopic aortic transplantation in mice. J Korean Med Sci. 2007 Feb; 22(1):12-5. PMID: 17297244; PMCID: PMC2693547.
    Citations: 2     Fields:    Translation:Animals
  24. Suh J, Lee YA, Gwag BJ. Induction and attenuation of neuronal apoptosis by proteasome inhibitors in murine cortical cell cultures. J Neurochem. 2005 Nov; 95(3):684-94. PMID: 16144541.
    Citations: 14     Fields:    Translation:AnimalsCells
  25. Kang JS, Jeon YJ, Suh J, Park SK, Yang KH, Kim HM. 2-Acetylaminofluorene inhibits interleukin-1beta production in LPS-stimulated macrophages by blocking NF-kappaB/Rel activation. Cancer Lett. 2004 Jan 08; 203(1):91-8. PMID: 14670622.
    Citations:    Fields:    Translation:AnimalsCells
  26. Suh J, Kang JS, Yang KH, Kaminski NE. Antagonism of aryl hydrocarbon receptor-dependent induction of CYP1A1 and inhibition of IgM expression by di-ortho-substituted polychlorinated biphenyls. Toxicol Appl Pharmacol. 2003 Feb 15; 187(1):11-21. PMID: 12628580.
    Citations: 18     Fields:    Translation:AnimalsCells
  27. Suh J, Jeon YJ, Kim HM, Kang JS, Kaminski NE, Yang KH. Aryl hydrocarbon receptor-dependent inhibition of AP-1 activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in activated B cells. Toxicol Appl Pharmacol. 2002 Jun 01; 181(2):116-23. PMID: 12051995.
    Citations: 28     Fields:    Translation:AnimalsCells
  28. Jeon YJ, Youk ES, Lee SH, Suh J, Na YJ, Kim HM. Polychlorinated biphenyl-induced apoptosis of murine spleen cells is aryl hydrocarbon receptor independent but caspases dependent. Toxicol Appl Pharmacol. 2002 Jun 01; 181(2):69-78. PMID: 12051990.
    Citations: 6     Fields:    Translation:Animals
  29. Na YJ, Jeon YJ, Suh JH, Kang JS, Yang KH, Kim HM. Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1/2 and p38 signaling and negative regulation of NF-kappaB and AP-1. Int Immunopharmacol. 2001 Sep; 1(9-10):1877-87. PMID: 11562079.
    Citations: 7     Fields:    Translation:HumansCells
  30. Chung J, Park ES, Kim D, Suh JM, Chung HK, Kim J, Kim H, Park SJ, Kwon OY, Ro HK, Shong M. Thyrotropin Modulates Interferon-?-Mediated Intercellular Adhesion Molecule-1 Gene Expression by Inhibiting Janus Kinase-1 and Signal Transducer and Activator of Transcription-1 Activation in Thyroid Cells. Endocrinology. 2000 Jun 01; 141(6):2090-2097. PMID: 28200942.
  31. Lee YW, Han SH, Suh JH, Jeon YJ, Yang KH. Down-regulation of protein kinase C: a potential mechanism for 2-amino-3-methylimidazo[4,5-f]quinoline-mediated immunosuppression. Toxicol Lett. 1998 Dec 28; 102-103:79-83. PMID: 10022236.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.