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Jaehong Suh, PH.D.

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Overview
Dr. Jaehong Suh studies the genetic and molecular mechanisms of Alzheimer’s disease (AD) and other neurodegenerative disorders, with the aim of identifying novel therapeutic targets and developing effective treatments for patients. Suh was involved in the identification of novel mutations from late-onset AD families in the prodomain of ADAM10, a major alpha-secretase that cleaves beta-amyloid (Abeta) region of amyloid precursor protein (APP). Subsequently, Suh and his colleagues generated a mouse model with the same mutations and showed that the ADAM10 mutations attenuate alpha-secretase activity of the enzyme, potentiate the accumulation of Abeta and decrease the generation of new neurons in the brain. Suh and his lab continue to characterize additional ADAM10 mutations, and identify novel ADAM10 substrates in the brain. Additionally, Suh is pursing mechanistic studies on another AD-associated gene, Ataxin-1, which was found recently in a genetic screen of AD families. Expansion of CAG trinucleotide repeat in Ataxin-1 gene is known to cause spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disease that primarily impairs coordinated movement. At MGH, Suh has also studied the role of FE65 and FE65L1 APP-binding proteins on APP processing in neurons and identified abnormal eye and muscle phenotypes in the knockout mice for the two genes.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee JH, Suh JH, Choi SY, Kang HJ, Lee HH, Ye BJ, Lee GR, Jung SW, Kim CJ, Lee-Kwon W, Park J, Myung K, Park NH, Kwon HM. Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis. Gut. 2018 Feb 02. PMID: 29420225.
    View in: PubMed
  2. Ke K, Sul OJ, Chung SW, Suh JH, Choi HS. Lack of NOD2 attenuates ovariectomy-induced bone loss via inhibition of osteoclasts. J Endocrinol. 2017 Nov; 235(2):85-96. PMID: 28778866.
    View in: PubMed
  3. Ke K, Safder MA, Sul OJ, Kim WK, Suh JH, Joe Y, Chung HT, Choi HS. Hemeoxygenase-1 maintains bone mass via attenuating a redox imbalance in osteoclast. Mol Cell Endocrinol. 2015 Jul 05; 409:11-20. PMID: 25841764.
    View in: PubMed
  4. Suh J, Moncaster JA, Wang L, Hafeez I, Herz J, Tanzi RE, Goldstein LE, Guénette SY. FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness. FASEB J. 2015 Jun; 29(6):2628-39. PMID: 25757569; PMCID: PMC4447227.
  5. Nensa FM, Neumann MH, Schrötter A, Przyborski A, Mastalski T, Susdalzew S, Looße C, Helling S, El Magraoui F, Erdmann R, Meyer HE, Uszkoreit J, Eisenacher M, Suh J, Guénette SY, Röhner N, Kögel D, Theiss C, Marcus K, Müller T. Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain. Mol Cell Proteomics. 2014 Feb; 13(2):475-88. PMID: 24284412; PMCID: PMC3916648.
  6. Suh J, Choi SH, Romano DM, Gannon MA, Lesinski AN, Kim DY, Tanzi RE. ADAM10 missense mutations potentiate ß-amyloid accumulation by impairing prodomain chaperone function. Neuron. 2013 Oct 16; 80(2):385-401. PMID: 24055016; PMCID: PMC4105199.
  7. Suh J, Lyckman A, Wang L, Eckman EA, Guénette SY. FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing. J Neurochem. 2011 Oct; 119(2):377-88. PMID: 21824144; PMCID: PMC3188680.
  8. Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ, Gwag BJ. Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice. Exp Mol Med. 2010 May 31; 42(5):386-94. PMID: 20368688; PMCID: PMC2877248.
  9. Suh J, Im DS, Moon GJ, Ryu KS, de Silva R, Choi IS, Lees AJ, Guénette SY, Tanzi RE, Gwag BJ. Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing. J Neurochem. 2010 Jul; 114(1):160-70. PMID: 20374429.
    View in: PubMed
  10. Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet. 2009 Oct 15; 18(20):3987-96. PMID: 19608551; PMCID: PMC2748890.
  11. Lee JK, Shin JH, Suh J, Choi IS, Ryu KS, Gwag BJ. Tissue inhibitor of metalloproteinases-3 (TIMP-3) expression is increased during serum deprivation-induced neuronal apoptosis in vitro and in the G93A mouse model of amyotrophic lateral sclerosis: a potential modulator of Fas-mediated apoptosis. Neurobiol Dis. 2008 May; 30(2):174-85. PMID: 18316197.
    View in: PubMed
  12. Cho HR, Suh JH, Lee EA, Kim JE, Lee SC, Kwon B. Improved surgical technique for heterotopic aortic transplantation in mice. J Korean Med Sci. 2007 Feb; 22(1):12-5. PMID: 17297244; PMCID: PMC2693547.
  13. Suh J, Lee YA, Gwag BJ. Induction and attenuation of neuronal apoptosis by proteasome inhibitors in murine cortical cell cultures. J Neurochem. 2005 Nov; 95(3):684-94. PMID: 16144541.
    View in: PubMed
  14. Kang JS, Jeon YJ, Suh J, Park SK, Yang KH, Kim HM. 2-Acetylaminofluorene inhibits interleukin-1beta production in LPS-stimulated macrophages by blocking NF-kappaB/Rel activation. Cancer Lett. 2004 Jan 08; 203(1):91-8. PMID: 14670622.
    View in: PubMed
  15. Suh J, Kang JS, Yang KH, Kaminski NE. Antagonism of aryl hydrocarbon receptor-dependent induction of CYP1A1 and inhibition of IgM expression by di-ortho-substituted polychlorinated biphenyls. Toxicol Appl Pharmacol. 2003 Feb 15; 187(1):11-21. PMID: 12628580.
    View in: PubMed
  16. Suh J, Jeon YJ, Kim HM, Kang JS, Kaminski NE, Yang KH. Aryl hydrocarbon receptor-dependent inhibition of AP-1 activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in activated B cells. Toxicol Appl Pharmacol. 2002 Jun 01; 181(2):116-23. PMID: 12051995.
    View in: PubMed
  17. Jeon YJ, Youk ES, Lee SH, Suh J, Na YJ, Kim HM. Polychlorinated biphenyl-induced apoptosis of murine spleen cells is aryl hydrocarbon receptor independent but caspases dependent. Toxicol Appl Pharmacol. 2002 Jun 01; 181(2):69-78. PMID: 12051990.
    View in: PubMed
  18. Na YJ, Jeon YJ, Suh JH, Kang JS, Yang KH, Kim HM. Suppression of IL-8 gene expression by radicicol is mediated through the inhibition of ERK1/2 and p38 signaling and negative regulation of NF-kappaB and AP-1. Int Immunopharmacol. 2001 Sep; 1(9-10):1877-87. PMID: 11562079.
    View in: PubMed
  19. Chung J, Park ES, Kim D, Suh JM, Chung HK, Kim J, Kim H, Park SJ, Kwon OY, Ro HK, Shong M. Thyrotropin Modulates Interferon-?-Mediated Intercellular Adhesion Molecule-1 Gene Expression by Inhibiting Janus Kinase-1 and Signal Transducer and Activator of Transcription-1 Activation in Thyroid Cells. Endocrinology. 2000 Jun 01; 141(6):2090-2097. PMID: 28200942.
    View in: PubMed
  20. Lee YW, Han SH, Suh JH, Jeon YJ, Yang KH. Down-regulation of protein kinase C: a potential mechanism for 2-amino-3-methylimidazo[4,5-f]quinoline-mediated immunosuppression. Toxicol Lett. 1998 Dec 28; 102-103:79-83. PMID: 10022236.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.