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Last Name

profileAlexander Anastasios Soukas, Ph.D., M.D.

TitleAssistant Professor of Medicine
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Center for Human Genetic Research, CPZN6224
185 Cambridge St
Boston MA 02114
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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AG058256     (SOUKAS, ALEXANDER A)Dec 1, 2017 - Nov 30, 2022
Genetic mechanisms of metformin's pro-longevity and anti-cancer effects
Role: Principal Investigator

R01DK101522     (SOUKAS, ALEXANDER A)Sep 12, 2014 - Jul 31, 2019
Epigenetic regulation of metabolism by target of rapamycin complex 2
Role: Principal Investigator

R03DK098436     (SOUKAS, ALEXANDER A)Mar 1, 2013 - Feb 28, 2015
Dissecting the molecular mechanism of metformin action
Role: Principal Investigator

K08DK087941     (SOUKAS, ALEXANDER A)Jul 1, 2010 - Jun 30, 2015
Obesity and diabetes genetics in Caenorhabditis elegans.
Role: Principal Investigator

F32DK080607     (SOUKAS, ALEXANDER A)Sep 24, 2007 - Sep 23, 2010
Obesity and diabetes genetics and therapeutics in Caenorhabditis elegans.
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Webster CM, Pino EC, Carr CE, Wu L, Zhou B, Cedillo L, Kacergis MC, Curran SP, Soukas AA. Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival. Cell Rep. 2017 Jul 18; 20(3):627-640. PMID: 28723566.
    View in: PubMed
  2. Wu L, Zhou B, Oshiro-Rapley N, Li M, Paulo JA, Webster CM, Mou F, Kacergis MC, Talkowski ME, Carr CE, Gygi SP, Zheng B, Soukas AA. An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer. Cell. 2016 Dec 15; 167(7):1705-1718.e13. PMID: 27984722.
    View in: PubMed
  3. Lynn DA, Dalton HM, Sowa JN, Wang MC, Soukas AA, Curran SP. Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15378-83. PMID: 26621724; PMCID: PMC4687584.
  4. Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE. ß-Aminoisobutyric acid induces browning of white fat and hepatic ß-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 07; 19(1):96-108. PMID: 24411942; PMCID: PMC4017355.
  5. Soukas AA, Carr CE, Ruvkun G. Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLoS Genet. 2013 Oct; 9(10):e1003908. PMID: 24204312; PMCID: PMC3812091.
  6. Webster CM, Wu L, Douglas D, Soukas AA. A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2. Development. 2013 Sep; 140(17):3601-12. PMID: 23884442; PMCID: PMC3742143.
  7. Pino EC, Webster CM, Carr CE, Soukas AA. Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis elegans. J Vis Exp. 2013 Mar 30; (73). PMID: 23568026; PMCID: PMC3944676.
  8. Yuan M, Pino E, Wu L, Kacergis M, Soukas AA. Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2. J Biol Chem. 2012 Aug 24; 287(35):29579-88. PMID: 22773877; PMCID: PMC3436168.
  9. O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 2009 Nov; 10(5):430-5. PMID: 19883620; PMCID: PMC2921818.
  10. Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009 Feb 15; 23(4):496-511. PMID: 19240135; PMCID: PMC2648650.
  11. Birsoy K, Soukas A, Torrens J, Ceccarini G, Montez J, Maffei M, Cohen P, Fayzikhodjaeva G, Viale A, Socci ND, Friedman JM. Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12985-90. PMID: 18753616; PMCID: PMC2526100.
  12. Montez JM, Soukas A, Asilmaz E, Fayzikhodjaeva G, Fantuzzi G, Friedman JM. Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2537-42. PMID: 15699332; PMCID: PMC548993.
  13. Cohen P, Yang G, Yu X, Soukas AA, Wolfish CS, Friedman JM, Li C. Induction of leptin receptor expression in the liver by leptin and food deprivation. J Biol Chem. 2005 Mar 18; 280(11):10034-9. PMID: 15644325.
    View in: PubMed
  14. Asilmaz E, Cohen P, Miyazaki M, Dobrzyn P, Ueki K, Fayzikhodjaeva G, Soukas AA, Kahn CR, Ntambi JM, Socci ND, Friedman JM. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J Clin Invest. 2004 Feb; 113(3):414-24. PMID: 14755338; PMCID: PMC324539.
  15. Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science. 2002 Jul 12; 297(5579):240-3. PMID: 12114623.
    View in: PubMed
  16. Chiellini C, Bertacca A, Novelli SE, Görgün CZ, Ciccarone A, Giordano A, Xu H, Soukas A, Costa M, Gandini D, Dimitri R, Bottone P, Cecchetti P, Pardini E, Perego L, Navalesi R, Folli F, Benzi L, Cinti S, Friedman JM, Hotamisligil GS, Maffei M. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. J Cell Physiol. 2002 Feb; 190(2):251-8. PMID: 11807829.
    View in: PubMed
  17. Soukas A, Socci ND, Saatkamp BD, Novelli S, Friedman JM. Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem. 2001 Sep 07; 276(36):34167-74. PMID: 11445576.
    View in: PubMed
  18. Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol. 2000 Jul; 20(14):5343-9. PMID: 10866690; PMCID: PMC85983.
  19. Soukas A, Cohen P, Socci ND, Friedman JM. Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev. 2000 Apr 15; 14(8):963-80. PMID: 10783168; PMCID: PMC316534.
  20. Ylikahri R, Heikkonen E, Soukas A. The sauna and alcohol. Ann Clin Res. 1988; 20(4):287-91. PMID: 3218903.
    View in: PubMed
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