Harvard Catalyst Profiles

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Alexander Anastasios Soukas, Ph.D., M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG058256 (SOUKAS, ALEXANDER A) Dec 1, 2017 - Nov 30, 2022
    Genetic mechanisms of metformin's pro-longevity and anti-cancer effects
    Role: Principal Investigator
  2. R01DK101522 (SOUKAS, ALEXANDER A) Sep 12, 2014 - Jul 31, 2019
    Epigenetic regulation of metabolism by target of rapamycin complex 2
    Role: Principal Investigator
  3. R03DK098436 (SOUKAS, ALEXANDER A) Mar 1, 2013 - Feb 28, 2015
    Dissecting the molecular mechanism of metformin action
    Role: Principal Investigator
  4. K08DK087941 (SOUKAS, ALEXANDER A) Jul 1, 2010 - Jun 30, 2015
    Obesity and diabetes genetics in Caenorhabditis elegans.
    Role: Principal Investigator
  5. F32DK080607 (SOUKAS, ALEXANDER A) Sep 24, 2007 - Sep 23, 2010
    Obesity and diabetes genetics and therapeutics in Caenorhabditis elegans.
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang L, Sinnott-Armstrong N, Wagschal A, Wark AR, Camporez JP, Perry RJ, Ji F, Sohn Y, Oh J, Wu S, Chery J, Moud BN, Saadat A, Dankel SN, Mellgren G, Tallapragada DSP, Strobel SM, Lee MJ, Tewhey R, Sabeti PC, Schaefer A, Petri A, Kauppinen S, Chung RT, Soukas A, Avruch J, Fried SK, Hauner H, Sadreyev RI, Shulman GI, Claussnitzer M, Näär AM. A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 2020 Oct 29; 183(3):684-701.e14. PMID: 33058756.
    Citations:    Fields:    
  2. Pino EC, Soukas AA. Quantitative Profiling of Lipid Species in Caenorhabditis elegans with Gas Chromatography-Mass Spectrometry. Methods Mol Biol. 2020; 2144:111-123. PMID: 32410029.
    Citations:    Fields:    
  3. Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F, Ferreira LMR, Chen Z, Chen T, Loaiza N, Horwitz NB, Kacergis MC, Zhao L, Soukas AA, Kuivenhoven JA, Kathiresan S, Cowan CA. GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Cell. 2019 11 27; 179(6):1276-1288.e14. PMID: 31778654.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Nhan JD, Turner CD, Anderson SM, Yen CA, Dalton HM, Cheesman HK, Ruter DL, Uma Naresh N, Haynes CM, Soukas AA, Pukkila-Worley R, Curran SP. Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection. Proc Natl Acad Sci U S A. 2019 10 29; 116(44):22322-22330. PMID: 31611372.
    Citations: 4     Fields:    Translation:AnimalsCells
  5. Soukas AA, Hao H, Wu L. Metformin as Anti-Aging Therapy: Is It for Everyone? Trends Endocrinol Metab. 2019 10; 30(10):745-755. PMID: 31405774.
    Citations: 13     Fields:    Translation:HumansCells
  6. Zhou B, Soukas AA. Suppressing the dark side of autophagy. Autophagy. 2019 10; 15(10):1852-1853. PMID: 31313620.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Anderson SM, Cheesman HK, Peterson ND, Salisbury JE, Soukas AA, Pukkila-Worley R. The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans. PLoS Pathog. 2019 06; 15(6):e1007893. PMID: 31206555.
    Citations: 5     Fields:    Translation:Animals
  8. Yerevanian A, Soukas AA. Metformin: Mechanisms in Human Obesity and Weight Loss. Curr Obes Rep. 2019 Jun; 8(2):156-164. PMID: 30874963.
    Citations: 5     Fields:    Translation:HumansAnimals
  9. Soukas AA, Zhou B. Surviving starvation simply without TFEB. PLoS Biol. 2019 05; 17(5):e3000285. PMID: 31136567.
    Citations:    Fields:    Translation:AnimalsCells
  10. Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer KJ, Cedillo L, Zhang Y, Li S, Kacergis MC, Webster CM, Fejes-Toth G, Naray-Fejes-Toth A, Das S, Hansen M, Haas W, Soukas AA. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Cell. 2019 04 04; 177(2):299-314.e16. PMID: 30929899.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  11. Xu S, Feliu M, Lord AK, Lukason DP, Negoro PE, Khan NS, Dagher Z, Feldman MB, Reedy JL, Steiger SN, Tam JM, Soukas AA, Sykes DB, Mansour MK. Biguanides enhance antifungal activity against Candida glabrata. Virulence. 2018; 9(1):1150-1162. PMID: 29962263.
    Citations: 3     Fields:    Translation:HumansAnimals
  12. Webster CM, Pino EC, Carr CE, Wu L, Zhou B, Cedillo L, Kacergis MC, Curran SP, Soukas AA. Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival. Cell Rep. 2017 07 18; 20(3):627-640. PMID: 28723566.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Wu L, Zhou B, Oshiro-Rapley N, Li M, Paulo JA, Webster CM, Mou F, Kacergis MC, Talkowski ME, Carr CE, Gygi SP, Zheng B, Soukas AA. An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer. Cell. 2016 Dec 15; 167(7):1705-1718.e13. PMID: 27984722.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  14. Lynn DA, Dalton HM, Sowa JN, Wang MC, Soukas AA, Curran SP. Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15378-83. PMID: 26621724.
    Citations: 21     Fields:    Translation:AnimalsCells
  15. Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE. ß-Aminoisobutyric acid induces browning of white fat and hepatic ß-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 07; 19(1):96-108. PMID: 24411942.
    Citations: 129     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  16. Soukas AA, Carr CE, Ruvkun G. Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLoS Genet. 2013 Oct; 9(10):e1003908. PMID: 24204312.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  17. Webster CM, Wu L, Douglas D, Soukas AA. A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2. Development. 2013 Sep; 140(17):3601-12. PMID: 23884442.
    Citations: 9     Fields:    Translation:Animals
  18. Pino EC, Webster CM, Carr CE, Soukas AA. Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis elegans. J Vis Exp. 2013 Mar 30; (73). PMID: 23568026.
    Citations: 24     Fields:    Translation:Animals
  19. Yuan M, Pino E, Wu L, Kacergis M, Soukas AA. Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2. J Biol Chem. 2012 Aug 24; 287(35):29579-88. PMID: 22773877.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  20. O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 2009 Nov; 10(5):430-5. PMID: 19883620.
    Citations: 162     Fields:    Translation:AnimalsCells
  21. Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009 Feb 15; 23(4):496-511. PMID: 19240135.
    Citations: 169     Fields:    Translation:AnimalsCells
  22. Birsoy K, Soukas A, Torrens J, Ceccarini G, Montez J, Maffei M, Cohen P, Fayzikhodjaeva G, Viale A, Socci ND, Friedman JM. Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12985-90. PMID: 18753616.
    Citations: 17     Fields:    Translation:AnimalsCells
  23. Montez JM, Soukas A, Asilmaz E, Fayzikhodjaeva G, Fantuzzi G, Friedman JM. Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2537-42. PMID: 15699332.
    Citations: 27     Fields:    Translation:Animals
  24. Cohen P, Yang G, Yu X, Soukas AA, Wolfish CS, Friedman JM, Li C. Induction of leptin receptor expression in the liver by leptin and food deprivation. J Biol Chem. 2005 Mar 18; 280(11):10034-9. PMID: 15644325.
    Citations: 30     Fields:    Translation:AnimalsCells
  25. Asilmaz E, Cohen P, Miyazaki M, Dobrzyn P, Ueki K, Fayzikhodjaeva G, Soukas AA, Kahn CR, Ntambi JM, Socci ND, Friedman JM. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J Clin Invest. 2004 Feb; 113(3):414-24. PMID: 14755338.
    Citations: 64     Fields:    Translation:Animals
  26. Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science. 2002 Jul 12; 297(5579):240-3. PMID: 12114623.
    Citations: 214     Fields:    Translation:AnimalsCells
  27. Chiellini C, Bertacca A, Novelli SE, Görgün CZ, Ciccarone A, Giordano A, Xu H, Soukas A, Costa M, Gandini D, Dimitri R, Bottone P, Cecchetti P, Pardini E, Perego L, Navalesi R, Folli F, Benzi L, Cinti S, Friedman JM, Hotamisligil GS, Maffei M. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. J Cell Physiol. 2002 Feb; 190(2):251-8. PMID: 11807829.
    Citations: 19     Fields:    Translation:AnimalsCells
  28. Soukas A, Socci ND, Saatkamp BD, Novelli S, Friedman JM. Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem. 2001 Sep 07; 276(36):34167-74. PMID: 11445576.
    Citations: 112     Fields:    Translation:AnimalsCells
  29. Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol. 2000 Jul; 20(14):5343-9. PMID: 10866690.
    Citations: 117     Fields:    Translation:HumansAnimalsCells
  30. Soukas A, Cohen P, Socci ND, Friedman JM. Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev. 2000 Apr 15; 14(8):963-80. PMID: 10783168.
    Citations: 129     Fields:    Translation:AnimalsCells
  31. Ylikahri R, Heikkonen E, Soukas A. The sauna and alcohol. Ann Clin Res. 1988; 20(4):287-91. PMID: 3218903.
    Citations: 4     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.