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Toni K. Choueiri, M.D.

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Biography
2006
AACR/ASCO Workshop on Methods in Clinical Cancer Research
2006 - 2007
Research Program Committee (RPC) Award Program
2006
TAP CaPSURE™ Scholarship
2007
ASCO Foundation MERIT Award
2007
ASCO-PROSTATE foundation MERIT Award
2007
Korea Urological Cancer Society Recognition Award
2013
The George P. Canellos Award for Excellence in Clinical Investigation and Patient Care
2016
Eugene P. Schonfeld Award
2018
Aresty Scholar
2018 - 2022
Highly Cited Researcher, Clinical Medicine (Top 1%)
2021
Giant of Cancer Care, Genitourinary Cancer
2022
Lifetime Achievement Award in Global Oncology

Overview
I lead the Genitourinary (GU) Medical Oncology Division at Dana-Farber Cancer Institute and I am a clinician and translational scientist specialized in the management of renal cell carcinoma (RCC). My clinical expertise in this area guides my translational research, which involves understanding RCC tumor biology (including genetics and the tumor microenvironment) and investigating tissue- and blood-based biomarkers. My laboratory initially focused on interrogating genomic alterations as biomarkers for anti-angiogenic drug efficacy in advanced RCC. Using multi-OMICS approaches, our focus has expanded to deciphering mechanisms of response and resistance to systemic therapy, including immune checkpoint inhibitors (ICIs) and novel agents. We also are designing biomarker-based clinical trials to provide rationale systemic therapies in patients with renal cancers. I have contributed to the understanding of the underlying biology and rationale for therapies in rare RCC variants such as papillary and sarcomatoid renal cancers, in addition to my contributions to the three The Cancer Genome Atlas (TCGA) working groups dedicated to kidney cancer. Finally, I have conceived, planned, and led several randomized clinical trials in metastatic and adjuvant RCC that lead to multiple FDA approvals. In any research project, I seek to assemble a team of scientists, clinicians, and statisticians at various career stages and from multiple disciplines, and emphasize critical thinking, teamwork, and mentorship to achieve our aims.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA266424 (CHOUEIRI, TONI) Jul 1, 2022 - Jun 30, 2027
    NIH
    Tissue-based biomarkers of anti-PD-1-based therapy in metastatic renal cell carcinoma
    Role: PI
  2. R21CA238053 (SIGNORETTI, SABINA) Jan 10, 2020 - Jun 30, 2022
    NIH
    Tissue-based predictive biomarkers for Cabozantinib therapy in metastatic renal cell carcinoma
    Role: Co-PI
  3. R21CA220253 (BRASTIANOS, PRISCILLA KALIOPI) Sep 1, 2018 - Aug 31, 2021
    NIH
    Identification of genomic drivers of brain metastases in renal cell carcinoma
    Role: Co-PI
  4. R21CA191687 (CHOUEIRI, TONI) Jul 9, 2015 - Jun 30, 2017
    NIH
    Genetic Predictors of Response to mTOR inhibitors in advanced Renal Cancer
    Role: PI

Featured Content

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.