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Elisabeth Dianne Riviello, M.D.

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Available: 07/01/23, Expires: 12/31/25

Acute hypoxemic respiratory failure is a common and deadly component of critical illness in low income countries (LICs). Even before the COVID-19 pandemic, the burden of hypoxemic critical illness in LICs was enormous, with pneumonia being the leading infectious cause of death worldwide, and hypoxemia causing additional mortality in other infections including malaria, tuberculosis, and resuscitated sepsis, as well as non-communicable diseases such as heart failure, asthma/COPD, cancer, and trauma. High flow oxygen therapy (HFO) is a system of delivering mixed humidified and heated oxygen and ambient air at flow rates up to 60 liters per minute through a large nasal cannula. HFO has been shown to reduce the need for intubation and in some cases reduce mortality, in adults with acute hypoxemic respiratory failure in high income countries (HICs). In LICs, the potential for mortality benefit from HFO may be greater because safe mechanical ventilation is largely unavailable. The goals of BREATHE are to quantify mortality impact and define implementation factors for HFO for adults with hypoxemia of any cause in LIC settings. A student on this project will be based at two sites in Rwanda, with trips to two sites in Kenya and one site in Malawi. The student will be integrally involved in all aspects of study design, team development, study staff training, patient enrolment, writing, and analysis. The student will facilitate all aspects of trial implementation at the sites, and may choose a sub-study area to primarily lead if desired. The student will learn about clinical trial implementation in resource variable settings.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mart MF, Sendagire C, Ely EW, Riviello ED, Twagirumugabe T. Oxygen as an Essential Medicine. Crit Care Clin. 2022 Oct; 38(4):795-808. PMID: 36162911; PMCID: PMC9417445.
    Citations:    Fields:    Translation:HumansPHPublic Health
  2. Riviello ED, Dechen T, O'Donoghue AL, Cocchi MN, Hayes MM, Molina RL, Moraco NH, Mosenthal A, Rosenblatt M, Talmor N, Walsh DP, Sontag DN, Stevens JP. Assessment of a Crisis Standards of Care Scoring System for Resource Prioritization and Estimated Excess Mortality by Race, Ethnicity, and Socially Vulnerable Area During a Regional Surge in COVID-19. JAMA Netw Open. 2022 03 01; 5(3):e221744. PMID: 35289860; PMCID: PMC8924715.
    Citations:    Fields:    Translation:Humans
  3. Gallifant J, Sharell D, Hashmi M, Riviello ED, Schultz MJ, Ulisubisya MM, Formenti F. Mechanical ventilators for low- and middle-income countries: informing a context-specific and sustainable design. Br J Anaesth. 2022 Apr; 128(4):e279-e281. PMID: 35151463; PMCID: PMC8828371.
    Citations:    Fields:    Translation:Humans
  4. Wick KD, McAuley DF, Levitt JE, Beitler JR, Annane D, Riviello ED, Calfee CS, Matthay MA. Promises and challenges of personalized medicine to guide ARDS therapy. Crit Care. 2021 11 23; 25(1):404. PMID: 34814925; PMCID: PMC8609268.
    Citations: 2     Fields:    Translation:Humans
  5. Cohen CL, Walker KH, Hsiang M, Sonenthal PD, Riviello ED, Rouhani SA, Lipnick MS, Merriam LT, Kim EY. Combating information chaos: a case for collaborative clinical guidelines in a pandemic. Cell Rep Med. 2021 08 17; 2(8):100375. PMID: 34337553; PMCID: PMC8313756.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  6. Smit MR, Pisani L, de Bock EJE, van der Heijden F, Paulus F, Beenen LFM, Leopold SJ, Huson MAM, Henwood PC, Riviello ED, Walden AP, Dondorp AM, Schultz MJ, Bos LDJ. Ultrasound versus Computed Tomography Assessment of Focal Lung Aeration in Invasively Ventilated ICU Patients. Ultrasound Med Biol. 2021 09; 47(9):2589-2597. PMID: 34172339.
    Citations: 2     Fields:    Translation:Humans
  7. Hopkinson DA, Mvukiyehe JP, Jayaraman SP, Syed AA, Dworkin MS, Mucyo W, Cyuzuzo T, Tuyizere A, Mukwesi C, Nyirigira G, Banguti PR, Riviello ED. Sepsis in two hospitals in Rwanda: A retrospective cohort study of presentation, management, outcomes, and predictors of mortality. PLoS One. 2021; 16(5):e0251321. PMID: 34038449.
    Citations:    Fields:    Translation:Humans
  8. Banerdt JK, Mateyo K, Yan Y, Liu D, Zuo Y, Di Gravio C, Thome JC, Riviello ED, Saylor D, Ely EW, Heimburger DC. Risk factors for delirium among hospitalized patients in Zambia. PLoS One. 2021; 16(4):e0249097. PMID: 33831010.
    Citations:    Fields:    Translation:Humans
  9. Banerdt JK, Mateyo K, Wang L, Lindsell CJ, Riviello ED, Saylor D, Heimburger DC, Ely EW. Delirium as a predictor of mortality and disability among hospitalized patients in Zambia. PLoS One. 2021; 16(2):e0246330. PMID: 33571227.
    Citations: 2     Fields:    Translation:Humans
  10. Klinger A, Mueller A, Sutherland T, Mpirimbanyi C, Nziyomaze E, Niyomugabo JP, Niyonsenga Z, Rickard J, Talmor DS, Riviello E. Predicting mortality in adults with suspected infection in a Rwandan hospital: an evaluation of the adapted MEWS, qSOFA and UVA scores. BMJ Open. 2021 02 10; 11(2):e040361. PMID: 33568365.
    Citations: 4     Fields:    Translation:Humans
  11. Rochwerg B, Einav S, Chaudhuri D, Mancebo J, Mauri T, Helviz Y, Goligher EC, Jaber S, Ricard JD, Rittayamai N, Roca O, Antonelli M, Maggiore SM, Demoule A, Hodgson CL, Mercat A, Wilcox ME, Granton D, Wang D, Azoulay E, Ouanes-Besbes L, Cinnella G, Rauseo M, Carvalho C, Dessap-Mekontso A, Fraser J, Frat JP, Gomersall C, Grasselli G, Hernandez G, Jog S, Pesenti A, Riviello ED, Slutsky AS, Stapleton RD, Talmor D, Thille AW, Brochard L, Burns KEA. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline. Intensive Care Med. 2020 12; 46(12):2226-2237. PMID: 33201321.
    Citations: 39     Fields:    Translation:Humans
  12. Papali A, Diaz JV, Carter EJ, Ferreira JC, Fowler R, Gebremariam TH, Gordon SB, Lee BW, Murthy S, Riviello ED, West TE, Adhikari NK. Academic careers in global pulmonary and critical care medicine. J Glob Health. 2020 Jun; 10(1):010313. PMID: 32257140.
    Citations:    Fields:    Translation:Humans
  13. Sutherland T, Moriau V, Niyonzima JM, Mueller A, Kabeja L, Twagirumugabe T, Rosenberg N, Umuhire OF, Talmor DS, Riviello ED. The "Just Right" Amount of Oxygen. Improving Oxygen Use in a Rwandan Emergency Department. Ann Am Thorac Soc. 2019 09; 16(9):1138-1142. PMID: 31145642.
    Citations: 2     Fields:    Translation:Humans
  14. Sutherland T, Mpirimbanyi C, Nziyomaze E, Niyomugabo JP, Niyonsenga Z, Muvunyi CM, Mueller A, Bebell LM, Nkubana T, Musoni E, Talmor D, Rickard J, Riviello ED. Widespread antimicrobial resistance among bacterial infections in a Rwandan referral hospital. PLoS One. 2019; 14(8):e0221121. PMID: 31443107.
    Citations: 8     Fields:    Translation:HumansCells
  15. Pisani L, Vercesi V, van Tongeren PSI, Lagrand WK, Leopold SJ, Huson MAM, Henwood PC, Walden A, Smit MR, Riviello ED, Pelosi P, Dondorp AM, Schultz MJ. The diagnostic accuracy for ARDS of global versus regional lung ultrasound scores - a post hoc analysis of an observational study in invasively ventilated ICU patients. Intensive Care Med Exp. 2019 Jul 25; 7(Suppl 1):44. PMID: 31346914; PMCID: PMC6658630.
    Citations: 19     
  16. Pingree EW, Freed JA, Riviello ED, Bilello LA, Hayne CC, Hibbert KA, Huang GC. A Tale of Two Rounds: Managing Conflict During the Worst of Times in Family-Centered Rounds. Hosp Pediatr. 2019 07; 9(7):563-565. PMID: 31217238.
    Citations:    Fields:    Translation:Humans
  17. Rochwerg B, Granton D, Wang DX, Helviz Y, Einav S, Frat JP, Mekontso-Dessap A, Schreiber A, Azoulay E, Mercat A, Demoule A, Lemiale V, Pesenti A, Riviello ED, Mauri T, Mancebo J, Brochard L, Burns K. High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis. Intensive Care Med. 2019 05; 45(5):563-572. PMID: 30888444.
    Citations: 133     Fields:    Translation:Humans
  18. Using research to prepare for outbreaks of severe acute respiratory infection. BMJ Glob Health. 2019; 4(1):e001061. PMID: 30899557; PMCID: PMC6407534.
    Citations: 4     Fields:    
  19. Diaz JV, Riviello ED, Papali A, Adhikari NKJ, Ferreira JC. Global Critical Care: Moving Forward in Resource-Limited Settings. Ann Glob Health. 2019 01 22; 85(1). PMID: 30741504.
    Citations: 19     Fields:    Translation:Humans
  20. Schultz MJ, Dünser MW, Dondorp AM, Adhikari NKJ, Iyer S, Kwizera A, Lubell Y, Papali A, Pisani L, Riviello ED, Angus DC, Azevedo LC, Baker T, Diaz JV, Festic E, Haniffa R, Jawa R, Jacob ST, Kissoon N, Lodha R, Martin-Loeches I, Lundeg G, Misango D, Mer M, Mohanty S, Murthy S, Musa N, Nakibuuka J, Neto AS, Mai NTH, Thien BN, Pattnaik R, Phua J, Preller J, Povoa P, Ranjit S, Talmor D, Thevanayagam J, Thwaites CL. Current Challenges in the Management of Sepsis in ICUs in Resource-Poor Settings and Suggestions for the Future. Sepsis Management in Resource-limited Settings. 2019. View Publication.
  21. Leopold SJ, Ghose A, Plewes KA, Mazumder S, Pisani L, Kingston HWF, Paul S, Barua A, Sattar MA, Huson MAM, Walden AP, Henwood PC, Riviello ED, Schultz MJ, Day NPJ, Kumar Dutta A, White NJ, Dondorp AM. Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study. PLoS One. 2018; 13(12):e0204832. PMID: 30540757; PMCID: PMC6291079.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  22. Vukoja M, Riviello ED, Schultz MJ. Critical care outcomes in resource-limited settings. Curr Opin Crit Care. 2018 10; 24(5):421-427. PMID: 30045088.
    Citations: 11     Fields:    Translation:Humans
  23. Vercesi V, Pisani L, van Tongeren PSI, Lagrand WK, Leopold SJ, Huson MMA, Henwood PC, Walden A, Smit M, Riviello ED, Pelosi P, Dondorp AM, Schultz MJ. Correction to: External confirmation and exploration of the Kigali modification for diagnosing moderate or severe ARDS. Intensive Care Med. 2018 03; 44(3):403-404. PMID: 29464297.
    Citations:    Fields:    
  24. Vercesi V, Pisani L, van Tongeren PSI, Lagrand WK, Leopold SJ, Huson MMA, Henwood PC, Walden A, Smit M, Riviello ED, Pelosi P, Dondorp AM, Schultz MJ. External confirmation and exploration of the Kigali modification for diagnosing moderate or severe ARDS. Intensive Care Med. 2018 04; 44(4):523-524. PMID: 29368056.
    Citations: 17     Fields:    Translation:Humans
  25. Haniffa R, Beane A, Baker T, Riviello ED, Schell CO, Dondorp AM. Development and internal validation of the Simplified Mortality Score for the Intensive Care Unit (SMS-ICU). Acta Anaesthesiol Scand. 2018 03; 62(3):407-408. PMID: 29368381.
    Citations: 2     Fields:    
  26. Pisani L, Riviello ED, Schultz MJ. Lung ultrasound and neonatal ARDS: is Montreux closer to Berlin than to Kigali? Lancet Respir Med. 2017 11; 5(11):e31. PMID: 29115272.
    Citations:    Fields:    Translation:Humans
  27. Schultz MJ, Dunser MW, Dondorp AM, Adhikari NK, Iyer S, Kwizera A, Lubell Y, Papali A, Pisani L, Riviello BD, Angus DC, Azevedo LC, Baker T, Diaz JV, Festic E, Haniffa R, Jawa R, Jacob ST, Kissoon N, Lodha R, Martin-Loeches I, Lundeg G, Misango D, Mer M, Mohanty S, Murthy S, Musa N, Nakibuuka J, Serpa Neto A, Nguyen Thi Hoang M, Nguyen Thien B, Pattnaik R, Phua J, Preller J, Povoa P, Ranjit S, Talmor D, Thevanayagam J, Thwaites CL. Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future. Intensive Care Med. 2017 May; 43(5):612-624. PMID: 28349179.
    Citations: 63     Fields:    Translation:Humans
  28. Riviello ED, Buregeya E, Twagirumugabe T. Diagnosing acute respiratory distress syndrome in resource limited settings: the Kigali modification of the Berlin definition. Curr Opin Crit Care. 2017 Feb; 23(1):18-23. PMID: 27875408.
    Citations: 10     Fields:    Translation:Humans
  29. Sutherland T, Musafiri S, Twagirumugabe T, Talmor D, Riviello ED. Oxygen as an Essential Medicine: Under- and Over-Treatment of Hypoxemia in Low- and High-Income Nations. Crit Care Med. 2016 10; 44(10):e1015-6. PMID: 27635514.
    Citations: 4     Fields:    Translation:Humans
  30. Riviello ED, Kiviri W, Fowler RA, Mueller A, Novack V, Banner-Goodspeed VM, Weinkauf JL, Talmor DS, Twagirumugabe T. Predicting Mortality in Low-Income Country ICUs: The Rwanda Mortality Probability Model (R-MPM). PLoS One. 2016; 11(5):e0155858. PMID: 27196252.
    Citations: 23     Fields:    Translation:Humans
  31. Riviello ED, Pisani L, Schultz MJ. What's new in ARDS: ARDS also exists in resource-constrained settings. Intensive Care Med. 2016 May; 42(5):794-796. PMID: 26984318; PMCID: PMC4828492.
    Citations: 4     Fields:    Translation:Humans
  32. Musabende M, Mukabatsinda C, Riviello ED, Ogbuagu O. Concurrent cryptococcal meningitis and disseminated tuberculosis occurring in an immunocompetent male. BMJ Case Rep. 2016 Feb 25; 2016. PMID: 26917794.
    Citations: 5     Fields:    Translation:Humans
  33. Riviello ED, Kiviri W, Twagirumugabe T, Mueller A, Banner-Goodspeed VM, Officer L, Novack V, Mutumwinka M, Talmor DS, Fowler RA. Hospital Incidence and Outcomes of the Acute Respiratory Distress Syndrome Using the Kigali Modification of the Berlin Definition. Am J Respir Crit Care Med. 2016 Jan 01; 193(1):52-9. PMID: 26352116.
    Citations: 111     Fields:    Translation:Humans
  34. Riviello ED, Letchford S, Cook EF, Waxman AB, Gaziano T. Improving decision making for massive transfusions in a resource poor setting: a preliminary study in Kenya. PLoS One. 2015; 10(5):e0127987. PMID: 26020935.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  35. Riviello ED, Sugira V, Twagirumugabe T. Sepsis research and the poorest of the poor. Lancet Infect Dis. 2015 May; 15(5):501-3. PMID: 25932573.
    Citations: 10     Fields:    Translation:Humans
  36. Riviello ED. Improving outcomes for severe sepsis in Africa: one step closer. Crit Care Med. 2014 Nov; 42(11):2439-40. PMID: 25319904.
    Citations: 4     Fields:    Translation:Humans
  37. Buregeya E, Fowler RA, Talmor DS, Twagirumugabe T, Kiviri W, Riviello ED. Acute respiratory distress syndrome in the global context. Glob Heart. 2014 Sep; 9(3):289-95. PMID: 25667180.
    Citations: 12     Fields:    Translation:Humans
  38. Vukoja M, Riviello E, Gavrilovic S, Adhikari NK, Kashyap R, Bhagwanjee S, Gajic O, Kilickaya O. A survey on critical care resources and practices in low- and middle-income countries. Glob Heart. 2014 Sep; 9(3):337-42.e1-5. PMID: 25667185.
    Citations: 36     Fields:    Translation:Humans
  39. Riviello ED, Letchford S, Achieng L, Newton MW. Critical care in resource-poor settings: lessons learned and future directions. Crit Care Med. 2011 Apr; 39(4):860-7. PMID: 21297458.
    Citations: 59     Fields:    Translation:Humans
  40. Riviello ED, Wang KC, Hochman ME, Sariban A, Da Rocha RC, Dogaru G, Christopher K. Vacuolization of tubules in gadolinium-associated acute renal failure. Rev Med Chir Soc Med Nat Iasi. 2009 Jan-Mar; 113(1):108-15. PMID: 21491811.
    Citations:    Fields:    Translation:Humans
  41. Riviello ED. Internship in Africa: death and life. Ann Intern Med. 2008 Sep 02; 149(5):353-4. PMID: 18765706.
    Citations:    Fields:    
  42. Poch E, Riviello ED, Christopher K. [Acute renal failure in the intensive care unit]. Med Clin (Barc). 2008 Feb 09; 130(4):141-8. PMID: 18279633.
    Citations:    Fields:    Translation:Humans
  43. Riviello ED, Sterling TR, Shepherd B, Fantan T, Makhema J. HIV in the workplace in Botswana: incidence, prevalence, and disease severity. AIDS Res Hum Retroviruses. 2007 Dec; 23(12):1453-60. PMID: 18160001.
    Citations: 3     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.