Harvard Catalyst Profiles

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Philippe Leboulch, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL090921 (LEBOULCH, PHILIPPE) Apr 1, 2008 - Sep 30, 2012
    Cell selection strategies for the gene therapy of the beta-hemoglobinopathies
    Role: Principal Investigator
  2. R01DK065939 (LEBOULCH, PHILIPPE) Sep 1, 2004 - Jun 30, 2009
    Novel Lentiviral Packaging Systems
    Role: Principal Investigator
  3. R21EB002891 (LEBOULCH, PHILIPPE) Sep 19, 2003 - Aug 31, 2006
    Semi-Synthetic, Site-Specifically Integrating Lentivirus
    Role: Principal Investigator
  4. R43CA077969 (LEBOULCH, PHILIPPE) Aug 5, 1998 - Jul 31, 1999
    Role: Principal Investigator
  5. P01HL055435 (NAGEL, RONALD L) Sep 30, 1995 - Aug 31, 2007
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kanter J, Thompson AA, Pierciey FJ, Hsieh M, Uchida N, Leboulch P, Schmidt M, Bonner M, Guo R, Miller A, Ribeil JA, Davidson D, Asmal M, Walters MC, Tisdale JF. Lovo-cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB-206 study. Am J Hematol. 2022 Sep 25. PMID: 36161320.
    Citations:    Fields:    
  2. Luce E, Steichen C, Abed S, Weber A, Leboulch P, Maouche-Chrétien L, Dubart-Kupperschmitt A. Successful Derivation of Hepatoblasts, Cholangiocytes and Hepatocytes from Simian Induced Pluripotent Stem Cells. Int J Mol Sci. 2022 Sep 17; 23(18). PMID: 36142774; PMCID: PMC9504404.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Magrin E, Semeraro M, Hebert N, Joseph L, Magnani A, Chalumeau A, Gabrion A, Roudaut C, Marouene J, Lefrere F, Diana JS, Denis A, Neven B, Funck-Brentano I, Negre O, Renolleau S, Brousse V, Kiger L, Touzot F, Poirot C, Bourget P, El Nemer W, Blanche S, Tréluyer JM, Asmal M, Walls C, Beuzard Y, Schmidt M, Hacein-Bey-Abina S, Asnafi V, Guichard I, Poirée M, Monpoux F, Touraine P, Brouzes C, de Montalembert M, Payen E, Six E, Ribeil JA, Miccio A, Bartolucci P, Leboulch P, Cavazzana M. Long-term outcomes of lentiviral gene therapy for the ß-hemoglobinopathies: the HGB-205 trial. Nat Med. 2022 01; 28(1):81-88. PMID: 35075288.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  4. Nualkaew T, Sii-Felice K, Giorgi M, McColl B, Gouzil J, Glaser A, Voon HPJ, Tee HY, Grigoriadis G, Svasti S, Fucharoen S, Hongeng S, Leboulch P, Payen E, Vadolas J. Coordinated ß-globin expression and a2-globin reduction in a multiplex lentiviral gene therapy vector for ß-thalassemia. Mol Ther. 2021 09 01; 29(9):2841-2853. PMID: 33940155; PMCID: PMC8417505.
    Citations: 3     Fields:    Translation:HumansCells
  5. Sii-Felice K, Castillo Padilla J, Relouzat F, Cheuzeville J, Tantawet S, Maouche L, Le Grand R, Leboulch P, Payen E. Enhanced Transduction of Macaca fascicularis Hematopoietic Cells with Chimeric Lentiviral Vectors. Hum Gene Ther. 2019 10; 30(10):1306-1323. PMID: 30848170.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Goupille O, Kadri Z, Langelé A, Luccantoni S, Badoual C, Leboulch P, Chrétien S. The integrity of the FOG-2 LXCXE pRb-binding motif is required for small intestine homeostasis. Exp Physiol. 2019 07; 104(7):1074-1089. PMID: 31012180.
    Citations:    Fields:    Translation:AnimalsCells
  7. Ngom M, Imren S, Maetzig T, Adair JE, Knapp DJHF, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RK. UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells. Mol Ther Methods Clin Dev. 2018 Sep 21; 10:156-164. PMID: 30101153; PMCID: PMC6077133.
    Citations: 6     
  8. Sii-Felice K, Giorgi M, Leboulch P, Payen E. Hemoglobin disorders: lentiviral gene therapy in the starting blocks to enter clinical practice. Exp Hematol. 2018 08; 64:12-32. PMID: 29807062.
    Citations: 12     Fields:    Translation:HumansCells
  9. Thompson AA, Walters MC, Kwiatkowski J, Rasko JEJ, Ribeil JA, Hongeng S, Magrin E, Schiller GJ, Payen E, Semeraro M, Moshous D, Lefrere F, Puy H, Bourget P, Magnani A, Caccavelli L, Diana JS, Suarez F, Monpoux F, Brousse V, Poirot C, Brouzes C, Meritet JF, Pondarré C, Beuzard Y, Chrétien S, Lefebvre T, Teachey DT, Anurathapan U, Ho PJ, von Kalle C, Kletzel M, Vichinsky E, Soni S, Veres G, Negre O, Ross RW, Davidson D, Petrusich A, Sandler L, Asmal M, Hermine O, De Montalembert M, Hacein-Bey-Abina S, Blanche S, Leboulch P, Cavazzana M. Gene Therapy in Patients with Transfusion-Dependent ß-Thalassemia. N Engl J Med. 2018 04 19; 378(16):1479-1493. PMID: 29669226.
    Citations: 193     Fields:    Translation:HumansCellsCTClinical Trials
  10. Goupille O, Penglong T, Kadri Z, Granger-Locatelli M, Denis R, Luquet S, Badoual C, Fucharoen S, Maouche-Chrétien L, Leboulch P, Chrétien S. The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis. Cell Rep. 2017 Dec 19; 21(12):3524-3535. PMID: 29262331.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Leboulch P, Cavazzana M. Gene Therapy in a Patient with Sickle Cell Disease. N Engl J Med. 2017 05 25; 376(21):2094. PMID: 28538131.
    Citations:    Fields:    Translation:Humans
  12. Ribeil JA, Hacein-Bey-Abina S, Payen E, Magnani A, Semeraro M, Magrin E, Caccavelli L, Neven B, Bourget P, El Nemer W, Bartolucci P, Weber L, Puy H, Meritet JF, Grevent D, Beuzard Y, Chrétien S, Lefebvre T, Ross RW, Negre O, Veres G, Sandler L, Soni S, de Montalembert M, Blanche S, Leboulch P, Cavazzana M. Gene Therapy in a Patient with Sickle Cell Disease. N Engl J Med. 2017 03 02; 376(9):848-855. PMID: 28249145.
    Citations: 227     Fields:    Translation:HumansCells
  13. Mouka A, Izard V, Tachdjian G, Brisset S, Yates F, Mayeur A, Drévillon L, Jarray R, Leboulch P, Maouche-Chrétien L, Tosca L. Induced pluripotent stem cell generation from a man carrying a complex chromosomal rearrangement as a genetic model for infertility studies. Sci Rep. 2017 01 03; 7:39760. PMID: 28045072; PMCID: PMC5206619.
    Citations: 3     Fields:    Translation:HumansCells
  14. Rousselot P, Prost S, Guilhot J, Roy L, Etienne G, Legros L, Charbonnier A, Coiteux V, Cony-Makhoul P, Huguet F, Cayssials E, Cayuela JM, Relouzat F, Delord M, Bruzzoni-Giovanelli H, Morisset L, Mahon FX, Guilhot F, Leboulch P. Pioglitazone together with imatinib in chronic myeloid leukemia: A proof of concept study. Cancer. 2017 05 15; 123(10):1791-1799. PMID: 28026860; PMCID: PMC5434901.
    Citations: 36     Fields:    Translation:HumansCTClinical Trials
  15. Ling C, Bhukhai K, Yin Z, Tan M, Yoder MC, Leboulch P, Payen E, Srivastava A. High-Efficiency Transduction of Primary Human Hematopoietic Stem/Progenitor Cells by AAV6 Vectors: Strategies for Overcoming Donor-Variation and Implications in Genome Editing. Sci Rep. 2016 10 19; 6:35495. PMID: 27759036.
    Citations: 17     Fields:    Translation:HumansCells
  16. de Dreuzy E, Bhukhai K, Leboulch P, Payen E. Current and future alternative therapies for beta-thalassemia major. Biomed J. 2016 Feb; 39(1):24-38. PMID: 27105596.
    Citations: 26     Fields:    Translation:HumansAnimals
  17. Goupille O, Penglong T, Kadri Z, Granger-Locatelli M, Fucharoen S, Maouche-Chrétien L, Prost S, Leboulch P, Chrétien S. Inhibition of the acetyl lysine-binding pocket of bromodomain and extraterminal domain proteins interferes with adipogenesis. Biochem Biophys Res Commun. 2016 Apr 15; 472(4):624-30. PMID: 26972250.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  18. Negre O, Eggimann AV, Beuzard Y, Ribeil JA, Bourget P, Borwornpinyo S, Hongeng S, Hacein-Bey S, Cavazzana M, Leboulch P, Payen E. Gene Therapy of the ß-Hemoglobinopathies by Lentiviral Transfer of the ß(A(T87Q))-Globin Gene. Hum Gene Ther. 2016 Feb; 27(2):148-65. PMID: 26886832; PMCID: PMC4779296.
    Citations: 61     Fields:    Translation:HumansCells
  19. Kadri Z, Lefevre C, Goupille O, Penglong T, Granger-Locatelli M, Fucharoen S, Maouche-Chretien L, Leboulch P, Chretien S. Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis. Genes Dev. 2015 Dec 15; 29(24):2603-16. PMID: 26680303; PMCID: PMC4699388.
    Citations: 14     Fields:    Translation:AnimalsCells
  20. Prel A, Caval V, Gayon R, Ravassard P, Duthoit C, Payen E, Maouche-Chretien L, Creneguy A, Nguyen TH, Martin N, Piver E, Sevrain R, Lamouroux L, Leboulch P, Deschaseaux F, Bouillé P, Sensébé L, Pagès JC. Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles. Mol Ther Methods Clin Dev. 2015; 2:15039. PMID: 26528487; PMCID: PMC4613645.
    Citations: 20     
  21. Prost S, Relouzat F, Spentchian M, Ouzegdouh Y, Saliba J, Massonnet G, Beressi JP, Verhoeyen E, Raggueneau V, Maneglier B, Castaigne S, Chomienne C, Chrétien S, Rousselot P, Leboulch P. Erosion of the chronic myeloid leukaemia stem cell pool by PPAR? agonists. Nature. 2015 Sep 17; 525(7569):380-3. PMID: 26331539.
    Citations: 112     Fields:    Translation:HumansCells
  22. Abed S, Tubsuwan A, Chaichompoo P, Park IH, Pailleret A, Benyoucef A, Tosca L, De Dreuzy E, Paulard A, Granger-Locatelli M, Relouzat F, Prost S, Tachdjian G, Fucharoen S, Daley GQ, Payen E, Chrétien S, Leboulch P, Maouche-Chrétien L. Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice. Haematologica. 2015 Oct; 100(10):e428-31. PMID: 26088930.
    Citations: 6     Fields:    Translation:AnimalsCells
  23. Negre O, Bartholomae C, Beuzard Y, Cavazzana M, Christiansen L, Courne C, Deichmann A, Denaro M, de Dreuzy E, Finer M, Fronza R, Gillet-Legrand B, Joubert C, Kutner R, Leboulch P, Maouche L, Paulard A, Pierciey FJ, Rothe M, Ryu B, Schmidt M, von Kalle C, Payen E, Veres G. Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of ß-thalassemia and sickle cell disease. Curr Gene Ther. 2015; 15(1):64-81. PMID: 25429463.
    Citations: 54     Fields:    Translation:AnimalsCells
  24. Arlet JB, Ribeil JA, Guillem F, Negre O, Hazoume A, Marcion G, Beuzard Y, Dussiot M, Moura IC, Demarest S, de Beauchêne IC, Belaid-Choucair Z, Sevin M, Maciel TT, Auclair C, Leboulch P, Chretien S, Tchertanov L, Baudin-Creuza V, Seigneuric R, Fontenay M, Garrido C, Hermine O, Courtois G. HSP70 sequestration by free a-globin promotes ineffective erythropoiesis in ß-thalassaemia. Nature. 2014 Oct 09; 514(7521):242-6. PMID: 25156257.
    Citations: 46     Fields:    Translation:HumansCells
  25. Dussiot M, Maciel TT, Fricot A, Chartier C, Negre O, Veiga J, Grapton D, Paubelle E, Payen E, Beuzard Y, Leboulch P, Ribeil JA, Arlet JB, Coté F, Courtois G, Ginzburg YZ, Daniel TO, Chopra R, Sung V, Hermine O, Moura IC. An activin receptor IIA ligand trap corrects ineffective erythropoiesis in ß-thalassemia. Nat Med. 2014 Apr; 20(4):398-407. PMID: 24658077.
    Citations: 116     Fields:    Translation:AnimalsCells
  26. Grosselin J, Sii-Felice K, Payen E, Chretien S, Tronik-Le Roux D, Leboulch P. Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics. Stem Cells. 2013 Oct; 31(10):2162-71. PMID: 23554255.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  27. Tubsuwan A, Abed S, Deichmann A, Kardel MD, Bartholomä C, Cheung A, Negre O, Kadri Z, Fucharoen S, von Kalle C, Payen E, Chrétien S, Schmidt M, Eaves CJ, Leboulch P, Maouche-Chrétien L. Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted ß-thalassemia patient. Stem Cells. 2013 Sep; 31(9):1785-94. PMID: 23712774.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  28. Leboulch P. Gene therapy: primed for take-off. Nature. 2013 Aug 15; 500(7462):280-2. PMID: 23955226.
    Citations: 4     Fields:    Translation:HumansCells
  29. Goupille O, Penglong T, Lefèvre C, Granger M, Kadri Z, Fucharoen S, Maouche-Chrétien L, Leboulch P, Chrétien S. BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7. Biochem Biophys Res Commun. 2012 Dec 07; 429(1-2):1-5. PMID: 23137537.
    Citations: 9     Fields:    Translation:HumansCells
  30. Verhoeyen E, Relouzat F, Cambot M, Costa C, Nègre D, Legrand F, Joubert C, Le Grand R, Cosset FL, Leboulch P, Dubart-Kupperschmitt A, Prost S. Stem cell factor-displaying simian immunodeficiency viral vectors together with a low conditioning regimen allow for long-term engraftment of gene-marked autologous hematopoietic stem cells in macaques. Hum Gene Ther. 2012 Jul; 23(7):754-68. PMID: 22463386.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  31. Payen E, Leboulch P. Advances in stem cell transplantation and gene therapy in the ß-hemoglobinopathies. Hematology Am Soc Hematol Educ Program. 2012; 2012:276-83. PMID: 23233592.
    Citations: 19     Fields:    Translation:HumansCells
  32. Payen E, Colomb C, Negre O, Beuzard Y, Hehir K, Leboulch P. Lentivirus vectors in ß-thalassemia. Methods Enzymol. 2012; 507:109-24. PMID: 22365771.
    Citations: 9     Fields:    Translation:HumansCells
  33. Saadi I, Alkuraya FS, Gisselbrecht SS, Goessling W, Cavallesco R, Turbe-Doan A, Petrin AL, Harris J, Siddiqui U, Grix AW, Hove HD, Leboulch P, Glover TW, Morton CC, Richieri-Costa A, Murray JC, Erickson RP, Maas RL. Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting. Am J Hum Genet. 2011 Jul 15; 89(1):44-55. PMID: 21703590.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  34. Negre O, Fusil F, Colomb C, Roth S, Gillet-Legrand B, Henri A, Beuzard Y, Bushman F, Leboulch P, Payen E. Correction of murine ß-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion. Blood. 2011 May 19; 117(20):5321-31. PMID: 21436071; PMCID: PMC3109707.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  35. Brady T, Roth SL, Malani N, Wang GP, Berry CC, Leboulch P, Hacein-Bey-Abina S, Cavazzana-Calvo M, Papapetrou EP, Sadelain M, Savilahti H, Bushman FD. A method to sequence and quantify DNA integration for monitoring outcome in gene therapy. Nucleic Acids Res. 2011 Jun; 39(11):e72. PMID: 21415009.
    Citations: 42     Fields:    Translation:HumansCells
  36. Ronen K, Negre O, Roth S, Colomb C, Malani N, Denaro M, Brady T, Fusil F, Gillet-Legrand B, Hehir K, Beuzard Y, Leboulch P, Down JD, Payen E, Bushman FD. Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat ß-thalassemia. Mol Ther. 2011 Jul; 19(7):1273-86. PMID: 21386821.
    Citations: 27     Fields:    Translation:AnimalsCells
  37. Cavazzana-Calvo M, Fischer A, Bushman FD, Payen E, Hacein-Bey-Abina S, Leboulch P. Is normal hematopoiesis maintained solely by long-term multipotent stem cells? Blood. 2011 Apr 28; 117(17):4420-4. PMID: 21304104; PMCID: PMC3099566.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  38. Cavazzana-Calvo M, Payen E, Negre O, Wang G, Hehir K, Fusil F, Down J, Denaro M, Brady T, Westerman K, Cavallesco R, Gillet-Legrand B, Caccavelli L, Sgarra R, Maouche-Chrétien L, Bernaudin F, Girot R, Dorazio R, Mulder GJ, Polack A, Bank A, Soulier J, Larghero J, Kabbara N, Dalle B, Gourmel B, Socie G, Chrétien S, Cartier N, Aubourg P, Fischer A, Cornetta K, Galacteros F, Beuzard Y, Gluckman E, Bushman F, Hacein-Bey-Abina S, Leboulch P. Transfusion independence and HMGA2 activation after gene therapy of human ß-thalassaemia. Nature. 2010 Sep 16; 467(7313):318-22. PMID: 20844535.
    Citations: 548     Fields:    Translation:HumansCells
  39. Wang GP, Berry CC, Malani N, Leboulch P, Fischer A, Hacein-Bey-Abina S, Cavazzana-Calvo M, Bushman FD. Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial. Blood. 2010 Jun 03; 115(22):4356-66. PMID: 20228274; PMCID: PMC2881494.
    Citations: 67     Fields:    Translation:HumansCellsCTClinical Trials
  40. Cartier N, Hacein-Bey-Abina S, Bartholomae CC, Veres G, Schmidt M, Kutschera I, Vidaud M, Abel U, Dal-Cortivo L, Caccavelli L, Mahlaoui N, Kiermer V, Mittelstaedt D, Bellesme C, Lahlou N, Lefrère F, Blanche S, Audit M, Payen E, Leboulch P, l'Homme B, Bougnères P, Von Kalle C, Fischer A, Cavazzana-Calvo M, Aubourg P. Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science. 2009 Nov 06; 326(5954):818-23. PMID: 19892975.
    Citations: 573     Fields:    Translation:HumansAnimalsCells
  41. Kadri Z, Shimizu R, Ohneda O, Maouche-Chretien L, Gisselbrecht S, Yamamoto M, Romeo PH, Leboulch P, Chretien S. Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis. PLoS Biol. 2009 Jun 09; 7(6):e1000123. PMID: 19513100.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  42. Simonnet AJ, Nehmé J, Vaigot P, Barroca V, Leboulch P, Tronik-Le Roux D. Phenotypic and functional changes induced in hematopoietic stem/progenitor cells after gamma-ray radiation exposure. Stem Cells. 2009 Jun; 27(6):1400-9. PMID: 19489102.
    Citations: 28     Fields:    Translation:AnimalsCells
  43. Comoy EE, Casalone C, Lescoutra-Etchegaray N, Zanusso G, Freire S, Marcé D, Auvré F, Ruchoux MM, Ferrari S, Monaco S, Salès N, Caramelli M, Leboulch P, Brown P, Lasmézas CI, Deslys JP. Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primate. PLoS One. 2008 Aug 20; 3(8):e3017. PMID: 18714385.
    Citations: 55     Fields:    Translation:HumansAnimals
  44. Negre O, Fusil F, Henri A, Villette JM, Leboulch P, Beuzard Y, Payen E. Activation and inhibition of the erythropoietin receptor by a membrane-anchored erythropoietin. Exp Hematol. 2008 Apr; 36(4):412-23. PMID: 18295963.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  45. Westerman KA, Ao Z, Cohen EA, Leboulch P. Design of a trans protease lentiviral packaging system that produces high titer virus. Retrovirology. 2007 Dec 28; 4:96. PMID: 18163907.
    Citations: 17     Fields:    Translation:HumansCells
  46. Totsugawa T, Yong C, Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T, Westerman KA, Kohara M, Reth M, Tanaka N, Leboulch P, Kobayashi N. Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination. J Hepatol. 2007 Jul; 47(1):74-82. PMID: 17434229.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  47. de Piédoue G, Andrieu-Soler C, Concordet JP, Maurisse R, Sun JS, Lopez B, Kuzniak I, Leboulch P, Feugeas JP. Targeted gene correction with 5' acridine-oligonucleotide conjugates. Oligonucleotides. 2007; 17(2):258-63. PMID: 17638529.
    Citations: 5     Fields:    Translation:Humans
  48. Qiu HY, Fujimori Y, Nishioka K, Yamaguchi N, Hashimoto-Tamaoki T, Sugihara A, Terada N, Nagaya N, Kanda M, Kobayashi N, Tanaka N, Westerman KA, Leboulch P, Hara H. Postnatal neovascularization by endothelial progenitor cells immortalized with the simian virus 40T antigen gene. Int J Oncol. 2006 Apr; 28(4):815-21. PMID: 16525629.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  49. Narushima M, Kobayashi N, Okitsu T, Tanaka Y, Li SA, Chen Y, Miki A, Tanaka K, Nakaji S, Takei K, Gutierrez AS, Rivas-Carrillo JD, Navarro-Alvarez N, Jun HS, Westerman KA, Noguchi H, Lakey JR, Leboulch P, Tanaka N, Yoon JW. A human beta-cell line for transplantation therapy to control type 1 diabetes. Nat Biotechnol. 2005 Oct; 23(10):1274-82. PMID: 16186810.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  50. Kadri Z, Maouche-Chretien L, Rooke HM, Orkin SH, Romeo PH, Mayeux P, Leboulch P, Chretien S. Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Mol Cell Biol. 2005 Sep; 25(17):7412-22. PMID: 16107690; PMCID: PMC1190299.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  51. Zhang JL, Cai J, Walls S, Jackson JD, Kuszynski CA, Zhao Y, Pawliuk R, Leboulch P, Fox IJ. Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrow. Transplantation. 2005 Aug 15; 80(3):362-9. PMID: 16082332.
    Citations:    Fields:    Translation:AnimalsCells
  52. de Piédoue G, Maurisse R, Kuzniak I, Lopez B, Perrin A, Nègre O, Leboulch P, Feugeas JP. Improving gene replacement by intracellular formation of linear homologous DNA. J Gene Med. 2005 May; 7(5):649-56. PMID: 15641108.
    Citations: 1     Fields:    Translation:AnimalsCells
  53. Dalle B, Rubin JE, Alkan O, Sukonnik T, Pasceri P, Yao S, Pawliuk R, Leboulch P, Ellis J. eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides. Mol Ther. 2005 Apr; 11(4):591-9. PMID: 15771961.
    Citations: 15     Fields:    Translation:AnimalsCells
  54. Bank A, Dorazio R, Leboulch P. A phase I/II clinical trial of beta-globin gene therapy for beta-thalassemia. Ann N Y Acad Sci. 2005; 1054:308-16. PMID: 16339679.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  55. Pawliuk R, Tighe R, Wise RJ, Mathews-Roth MM, Leboulch P. Prevention of murine erythropoietic protoporphyria-associated skin photosensitivity and liver disease by dermal and hepatic ferrochelatase. J Invest Dermatol. 2005 Jan; 124(1):256-62. PMID: 15654982.
    Citations: 5     Fields:    Translation:AnimalsCells
  56. Dalle B, Rubin JE, Alkan O, Sukonnik T, Pasceri P, Yao S, Pawliuk R, Leboulch P, Ellis J. eGFP reporter genes silence LCRß-globin transgene expression via CpG dinucleotides. Mol Ther. 2005 Apr; 11(4):591-599. PMID: 28182869.
  57. Mahieu-Caputo D, Allain JE, Branger J, Coulomb A, Delgado JP, Andreoletti M, Mainot S, Frydman R, Leboulch P, Di Santo JP, Capron F, Weber A. Repopulation of athymic mouse liver by cryopreserved early human fetal hepatoblasts. Hum Gene Ther. 2004 Dec; 15(12):1219-28. PMID: 15684698.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  58. Imren S, Fabry ME, Westerman KA, Pawliuk R, Tang P, Rosten PM, Nagel RL, Leboulch P, Eaves CJ, Humphries RK. High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells. J Clin Invest. 2004 Oct; 114(7):953-62. PMID: 15467834; PMCID: PMC518665.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  59. Matsumura T, Takesue M, Westerman KA, Okitsu T, Sakaguchi M, Fukazawa T, Totsugawa T, Noguchi H, Yamamoto S, Stolz DB, Tanaka N, Leboulch P, Kobayashi N. Establishment of an immortalized human-liver endothelial cell line with SV40T and hTERT. Transplantation. 2004 May 15; 77(9):1357-65. PMID: 15167590.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  60. Oh IH, Fabry ME, Humphries RK, Pawliuk R, Leboulch P, Hoffman R, Nagel RL, Eaves C. Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells. Exp Hematol. 2004 May; 32(5):461-9. PMID: 15145214.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  61. Rivier F, Alkan O, Flint AF, Muskiewicz K, Allen PD, Leboulch P, Gussoni E. Role of bone marrow cell trafficking in replenishing skeletal muscle SP and MP cell populations. J Cell Sci. 2004 Apr 15; 117(Pt 10):1979-88. PMID: 15054107.
    Citations: 14     Fields:    Translation:AnimalsCells
  62. Geromin D, Bourge JF, Soulié A, Pawliuk R, Fleet C, Michel E, Denizot Y, Berthou C, Leboulch P, Sigaux F, Sasportes M. Glycoprotein 170 induces platelet-activating factor receptor membrane expression and confers tumor cell hypersensitivity to NK-dependent cell lysis. J Immunol. 2004 Mar 15; 172(6):3604-11. PMID: 15004162.
    Citations: 1     Fields:    Translation:HumansCells
  63. Maruyama M, Kobayashi N, Westerman KA, Sakaguchi M, Allain JE, Totsugawa T, Okitsu T, Fukazawa T, Weber A, Stolz DB, Leboulch P, Tanaka N. Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT. Transplantation. 2004 Feb 15; 77(3):446-51. PMID: 14966424.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  64. Okitsu T, Kobayashi N, Jun HS, Shin S, Kim SJ, Han J, Kwon H, Sakaguchi M, Totsugawa T, Kohara M, Westerman KA, Tanaka N, Leboulch P, Yoon JW. Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs. Diabetes. 2004 Jan; 53(1):105-12. PMID: 14693704.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  65. Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science. 2003 Oct 17; 302(5644):415-9. PMID: 14564000.
    Citations: 1178     Fields:    Translation:HumansCells
  66. Nishioka K, Fujimori Y, Hashimoto-Tamaoki T, Kai S, Qiu H, Kobayashi N, Tanaka N, Westerman KA, Leboulch P, Hara H. Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells. Int J Oncol. 2003 Oct; 23(4):925-32. PMID: 12963970.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  67. Watanabe T, Shibata N, Westerman KA, Okitsu T, Allain JE, Sakaguchi M, Totsugawa T, Maruyama M, Matsumura T, Noguchi H, Yamamoto S, Hikida M, Ohmori A, Reth M, Weber A, Tanaka N, Leboulch P, Kobayashi N. Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers. Transplantation. 2003 Jun 15; 75(11):1873-80. PMID: 12811248.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  68. de Franceschi L, Baron A, Scarpa A, Adrie C, Janin A, Barbi S, Kister J, Rouyer-Fessard P, Corrocher R, Leboulch P, Beuzard Y. Inhaled nitric oxide protects transgenic SAD mice from sickle cell disease-specific lung injury induced by hypoxia/reoxygenation. Blood. 2003 Aug 01; 102(3):1087-96. PMID: 12689931.
    Citations: 30     Fields:    Translation:Animals
  69. Gouze E, Pawliuk R, Gouze JN, Pilapil C, Fleet C, Palmer GD, Evans CH, Leboulch P, Ghivizzani SC. Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation. Mol Ther. 2003 Apr; 7(4):460-6. PMID: 12727108.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  70. Cao R, Bråkenhielm E, Pawliuk R, Wariaro D, Post MJ, Wahlberg E, Leboulch P, Cao Y. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med. 2003 May; 9(5):604-13. PMID: 12669032.
    Citations: 215     Fields:    Translation:Animals
  71. Imren S, Payen E, Westerman KA, Pawliuk R, Fabry ME, Eaves CJ, Cavilla B, Wadsworth LD, Beuzard Y, Bouhassira EE, Russell R, London IM, Nagel RL, Leboulch P, Humphries RK. Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14380-5. PMID: 12391330; PMCID: PMC137892.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  72. Nicolini FE, Imren S, Oh IH, Humphries RK, Leboulch P, Fabry ME, Nagel RL, Eaves CJ. Expression of a human beta-globin transgene in erythroid cells derived from retrovirally transduced transplantable human fetal liver and cord blood cells. Blood. 2002 Aug 15; 100(4):1257-64. PMID: 12149206.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  73. Cai J, Ito M, Nagata H, Westerman KA, Lafleur D, Chowdhury JR, Leboulch P, Fox IJ. Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes. Hepatology. 2002 Aug; 36(2):386-94. PMID: 12143047.
    Citations: 15     Fields:    Translation:AnimalsCells
  74. Maurisse R, Feugeas JP, Biet E, Kuzniak I, Leboulch P, Dutreix M, Sun JS. A new method (GOREC) for directed mutagenesis and gene repair by homologous recombination. Gene Ther. 2002 Jun; 9(11):703-7. PMID: 12032692.
    Citations: 2     Fields:    Translation:AnimalsCells
  75. Gouze E, Pawliuk R, Pilapil C, Gouze JN, Fleet C, Palmer GD, Evans CH, Leboulch P, Ghivizzani SC. In vivo gene delivery to synovium by lentiviral vectors. Mol Ther. 2002 Apr; 5(4):397-404. PMID: 11945066.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  76. Eisterer W, Jiang X, Bachelot T, Pawliuk R, Abramovich C, Leboulch P, Hogge D, Eaves C. Unfulfilled promise of endostatin in a gene therapy-xenotransplant model of human acute lymphocytic leukemia. Mol Ther. 2002 Apr; 5(4):352-9. PMID: 11945061.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  77. Pawliuk R, Bachelot T, Zurkiya O, Eriksson A, Cao Y, Leboulch P. Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells. Mol Ther. 2002 Apr; 5(4):345-51. PMID: 11945060.
    Citations: 8     Fields:    Translation:AnimalsCells
  78. Allain JE, Dagher I, Mahieu-Caputo D, Loux N, Andreoletti M, Westerman K, Briand P, Franco D, Leboulch P, Weber A. Immortalization of a primate bipotent epithelial liver stem cell. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3639-44. PMID: 11904425; PMCID: PMC122576.
    Citations: 16     Fields:    Translation:AnimalsCells
  79. Eriksson A, Cao R, Pawliuk R, Berg SM, Tsang M, Zhou D, Fleet C, Tritsaris K, Dissing S, Leboulch P, Cao Y. Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers. Cancer Cell. 2002 Feb; 1(1):99-108. PMID: 12086892.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  80. Noguchi H, Kobayashi N, Westerman KA, Sakaguchi M, Okitsu T, Totsugawa T, Watanabe T, Matsumura T, Fujiwara T, Ueda T, Miyazaki M, Tanaka N, Leboulch P. Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization. Hum Gene Ther. 2002 Jan 20; 13(2):321-34. PMID: 11812287.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  81. Pawliuk R, Westerman KA, Fabry ME, Payen E, Tighe R, Bouhassira EE, Acharya SA, Ellis J, London IM, Eaves CJ, Humphries RK, Beuzard Y, Nagel RL, Leboulch P. Correction of sickle cell disease in transgenic mouse models by gene therapy. Science. 2001 Dec 14; 294(5550):2368-71. PMID: 11743206.
    Citations: 149     Fields:    Translation:HumansAnimalsCells
  82. Han AP, Yu C, Lu L, Fujiwara Y, Browne C, Chin G, Fleming M, Leboulch P, Orkin SH, Chen JJ. Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J. 2001 Dec 03; 20(23):6909-18. PMID: 11726526; PMCID: PMC125753.
    Citations: 161     Fields:    Translation:AnimalsCells
  83. Kobayashi N, Miyazaki M, Westerman KA, Noguchi H, Sakaguchi M, Totsugawa T, Watanabe T, Matsumura T, Fujiwara T, Leboulch P, Tanaka N, Namba M. Construction of a differentiated human hepatocyte cell line expressing the herpes simplex virus-thymidine kinase gene. ASAIO J. 2001 Sep-Oct; 47(5):476-80. PMID: 11575821.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  84. Kobayashi N, Westerman KA, Tanaka N, Fox IJ, Leboulch P. A reversibly immortalized human hepatocyte cell line as a source of hepatocyte-based biological support. Addict Biol. 2001 Sep; 6(4):293-300. PMID: 11900607.
    Citations: 5     Fields:    
  85. Kobayashi N, Westerman KA, Taguchi T, Sakaguchi M, Fujiwara T, Urata H, Kishimoto N, Hayashi N, Nakaji S, Murakami T, Leboulch P, Tanaka N. Expansion of human hepatocyte populations by a retroviral gene transfer of simian virus 40 large T antigen. ASAIO J. 2001 Sep-Oct; 47(5):481-5. PMID: 11575822.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  86. Kobayashi N, Noguchi H, Westerman KA, Watanabe T, Matsumura T, Totsugawa T, Fujiwara T, Leboulch P, Tanaka N. Successful Retroviral Gene Transfer of Simian Virus 40 T Antigen and Herpes Simplex Virus-Thymidine Kinase into Human Hepatocytes 1. Cell Transplant. 2001 May/Jul; 10(4-5):377-381. PMID: 28886299.
    Citations: 1     Fields:    
  87. Kobayashi N, Noguchi H, Westerman KA, Watanabe T, Matsumura T, Totsugawa T, Fujiwara T, Leboulch P, Tanaka N. Cre/loxP-Based Reversible Immortalization of Human Hepatocytes 1. Cell Transplant. 2001 May/Jul; 10(4-5):383-386. PMID: 28886302.
    Citations: 1     Fields:    
  88. Kobayashi N, Noguchi H, Westerman KA, Watanabe T, Matsumura T, Totsugawa T, Fujiwara T, Leboulch P, Tanaka N. Successful retroviral gene transfer of simian virus 40 T antigen and herpes simplex virus-thymidine kinase into human hepatocytes. Cell Transplant. 2001; 10(4-5):377-81. PMID: 11549057.
    Citations:    Fields:    Translation:HumansCells
  89. Kobayashi N, Noguchi H, Westerman KA, Watanabe T, Matsumura T, Totsugawa T, Fujiwara T, Leboulch P, Tanaka N. Cre/loxP-based reversible immortalization of human hepatocytes. Cell Transplant. 2001; 10(4-5):383-6. PMID: 11549058.
    Citations: 4     Fields:    Translation:HumansCells
  90. Jouanneau E, Alberti L, Nejjari M, Treilleux I, Vilgrain I, Duc A, Combaret V, Favrot M, Leboulch P, Bachelot T. Lack of antitumor activity of recombinant endostatin in a human neuroblastoma xenograft model. J Neurooncol. 2001 Jan; 51(1):11-8. PMID: 11349875.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  91. Kobayashi N, Noguchi H, Watanabe T, Matsumura T, Totsugawa T, Fujiwara T, Taguchi T, Urata H, Kishimoto N, Hayashi N, Nakaji S, Westerman KA, Leboulch P, Murakami T, Tanaka N. A new approach to develop a biohybrid artificial liver using a tightly regulated human hepatocyte cell line. Hum Cell. 2000 Dec; 13(4):229-35. PMID: 11329939.
    Citations:    Fields:    Translation:HumansAnimalsCells
  92. Kobayashi N, Noguchi H, Fujiwara T, Westerman KA, Leboulch P, Tanaka N. Establishment of a highly differentiated immortalized adult human hepatocyte cell line by retroviral gene transfer. Transplant Proc. 2000 Nov; 32(7):2368-9. PMID: 11120203.
    Citations: 8     Fields:    Translation:HumansCells
  93. Crosby JS, Chefalo PJ, Yeh I, Ying S, London IM, Leboulch P, Chen JJ. Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase. Blood. 2000 Nov 01; 96(9):3241-8. PMID: 11050009.
    Citations: 17     Fields:    Translation:AnimalsCells
  94. Cai J, Ito M, Westerman KA, Kobayashi N, Leboulch P, Fox IJ. Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen. J Hepatol. 2000 Nov; 33(5):701-8. PMID: 11097476.
    Citations: 10     Fields:    Translation:AnimalsCells
  95. Kobayashi N, Noguchi H, Westerman KA, Matsumura T, Watanabe T, Totsugawa T, Fujiwara T, Leboulch P, Tanaka N. Efficient Cre/loxP site-specific recombination in a HepG2 human liver cell line. Cell Transplant. 2000 Sep-Oct; 9(5):737-42. PMID: 11144976.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  96. Rubin JE, Pasceri P, Wu X, Leboulch P, Ellis J. Locus control region activity by 5'HS3 requires a functional interaction with beta-globin gene regulatory elements: expression of novel beta/gamma-globin hybrid transgenes. Blood. 2000 May 15; 95(10):3242-9. PMID: 10807795.
    Citations: 8     Fields:    Translation:HumansAnimals
  97. Kalberer CP, Pawliuk R, Imren S, Bachelot T, Takekoshi KJ, Fabry M, Eaves CJ, London IM, Humphries RK, Leboulch P. Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5411-5. PMID: 10792053; PMCID: PMC25842.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  98. Kobayashi N, Noguchi H, Watanabe T, Matsumura T, Totsugawa T, Fujiwara T, Westerman K, Leboulch P, Fox IJ, Tanaka N. Establishment of a tightly regulated human cell line for the development of hepatocyte transplantation. Hum Cell. 2000 Mar; 13(1):7-13. PMID: 10937342.
    Citations: 1     Fields:    Translation:HumansCells
  99. Kobayashi N, Fujiwara T, Westerman KA, Inoue Y, Sakaguchi M, Noguchi H, Miyazaki M, Cai J, Tanaka N, Fox IJ, Leboulch P. Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes. Science. 2000 Feb 18; 287(5456):1258-62. PMID: 10678831.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  100. Feng YQ, Seibler J, Alami R, Eisen A, Westerman KA, Leboulch P, Fiering S, Bouhassira EE. Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange. J Mol Biol. 1999 Oct 01; 292(4):779-85. PMID: 10525404.
    Citations: 81     Fields:    Translation:AnimalsCells
  101. Lai CC, Gouras P, Doi K, Lu F, Kjeldbye H, Goff SP, Pawliuk R, Leboulch P, Tsang SH. Tracking RPE transplants labeled by retroviral gene transfer with green fluorescent protein. Invest Ophthalmol Vis Sci. 1999 Aug; 40(9):2141-6. PMID: 10440271.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  102. Pawliuk R, Bachelot T, Wise RJ, Mathews-Roth MM, Leboulch P. Long-term cure of the photosensitivity of murine erythropoietic protoporphyria by preselective gene therapy. Nat Med. 1999 Jul; 5(7):768-73. PMID: 10395321.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  103. Hennemann B, Conneally E, Pawliuk R, Leboulch P, Rose-John S, Reid D, Chuo JY, Humphries RK, Eaves CJ. Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables. Exp Hematol. 1999 May; 27(5):817-25. PMID: 10340397.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  104. Pawliuk R, Bachelot T, Raftopoulos H, Kalberer C, Humphries RK, Bank A, Leboulch P. Retroviral vectors aimed at the gene therapy of human beta-globin gene disorders. Ann N Y Acad Sci. 1998 Jun 30; 850:151-62. PMID: 9668537.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  105. Raftopoulos H, Ward M, Leboulch P, Bank A. Long-term transfer and expression of the human beta-globin gene in a mouse transplant model. Blood. 1997 Nov 01; 90(9):3414-22. PMID: 9345024.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  106. Bouhassira EE, Westerman K, Leboulch P. Transcriptional behavior of LCR enhancer elements integrated at the same chromosomal locus by recombinase-mediated cassette exchange. Blood. 1997 Nov 01; 90(9):3332-44. PMID: 9345015.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  107. Qing K, Bachelot T, Mukherjee P, Wang XS, Peng L, Yoder MC, Leboulch P, Srivastava A. Adeno-associated virus type 2-mediated transfer of ecotropic retrovirus receptor cDNA allows ecotropic retroviral transduction of established and primary human cells. J Virol. 1997 Jul; 71(7):5663-7. PMID: 9188645; PMCID: PMC191813.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  108. Liger D, vanderSpek JC, Gaillard C, Cansier C, Murphy JR, Leboulch P, Gillet D. Characterization and receptor specific toxicity of two diphtheria toxin-related interleukin-3 fusion proteins DAB389-mIL-3 and DAB389-(Gly4Ser)2-mIL-3. FEBS Lett. 1997 Apr 07; 406(1-2):157-61. PMID: 9109408.
    Citations: 2     Fields:    Translation:AnimalsCells
  109. Westerman KA, Leboulch P. Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):8971-6. PMID: 8799138; PMCID: PMC38579.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  110. Rosenwald IB, Kaspar R, Rousseau D, Gehrke L, Leboulch P, Chen JJ, Schmidt EV, Sonenberg N, London IM. Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. J Biol Chem. 1995 Sep 08; 270(36):21176-80. PMID: 7673150.
    Citations: 73     Fields:    Translation:AnimalsCells
  111. Takekoshi KJ, Oh YH, Westerman KW, London IM, Leboulch P. Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):3014-8. PMID: 7708766; PMCID: PMC42349.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  112. Leboulch P, Huang GM, Humphries RK, Oh YH, Eaves CJ, Tuan DY, London IM. Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure. EMBO J. 1994 Jul 01; 13(13):3065-76. PMID: 8039501; PMCID: PMC395197.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  113. Castella-Escola J, Ojcius DM, LeBoulch P, Joulin V, Blouquit Y, Garel MC, Valentin C, Rosa R, Climent-Romeo F, Cohen-Solal M. Isolation and characterization of the gene encoding the muscle-specific isozyme of human phosphoglycerate mutase. Gene. 1990 Jul 16; 91(2):225-32. PMID: 2145198.
    Citations: 8     Fields:    Translation:HumansCells
  114. Raich N, Mignotte V, Dubart A, Beaupain D, Leboulch P, Romana M, Chabret C, Charnay P, Papayannopoulou T, Goossens M, et al. Regulated expression of the overlapping ubiquitous and erythroid transcription units of the human porphobilinogen deaminase (PBG-D) gene introduced into non-erythroid and erythroid cells. J Biol Chem. 1989 Jun 15; 264(17):10186-92. PMID: 2542327.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.