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Manfred Brigl, M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI125322 (BRIGL, MANFRED) Jun 9, 2016 - May 31, 2021
    MR1 and MAIT Cell Function in Intestinal Infection
    Role: Principal Investigator
  2. R21AI111039 (BRIGL, MANFRED) Apr 8, 2015 - Mar 31, 2017
    Role of MR1-Restricted MAIT Cells in Intestinal Infection
    Role: Principal Investigator
  3. R21AI103616 (BRIGL, MANFRED) May 24, 2013 - Apr 30, 2015
    Role of type II NKT cells during M. tuberculosis infection
    Role: Principal Investigator
  4. K08AI077795 (BRIGL, MANFRED) Feb 15, 2008 - Jan 31, 2013
    CD1d-restricted NKT cells in microbial infection
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rhee C, Baker MA, Tucker R, Vaidya V, Holtzman M, Seethala RR, Bentain-Melanson M, Lenox J, Smith AR, Boyer JC, Gassett A, Brigl M, Sater M, Huntley M, Woolley AE, Goldberg HJ, Reilly K, Resnick A, Pearson M, Klompas M. Cluster of Burkholderia cepacia Complex Infections Associated with Extracorporeal Membrane Oxygenation Water Heater Devices. Clin Infect Dis. 2022 Mar 10. PMID: 35271726.
    Citations:    Fields:    
  2. Tsai JM, Tolan NV, Petrides AK, Kanjilal S, Brigl M, Lindeman NI, Li YD, Tanasijevic MJ, Basu SS, Melanson SEF. How SARS-CoV-2 Transformed the Clinical Laboratory: Challenges and Lessons Learned. J Appl Lab Med. 2021 09 01; 6(5):1338-1354. PMID: 33822967.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  3. Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, Solomon IH, Kuo HH, Boucau J, Bowman K, Adhikari UD, Winkler ML, Mueller AA, Hsu TY, Desjardins M, Baden LR, Chan BT, Walker BD, Lichterfeld M, Brigl M, Kwon DS, Kanjilal S, Richardson ET, Jonsson AH, Alter G, Barczak AK, Hanage WP, Yu XG, Gaiha GD, Seaman MS, Cernadas M, Li JZ. Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host. N Engl J Med. 2020 12 03; 383(23):2291-2293. PMID: 33176080; PMCID: PMC7673303.
    Citations: 363     Fields:    Translation:HumansCells
  4. Matias WR, Vaidya A, Brigl M, Bebell LM. A Patient with Fever and Dyspnea. N Engl J Med. 2020 Nov 05; 383(19):e111. PMID: 33211933.
    Citations:    Fields:    Translation:HumansCells
  5. Almeida CF, Sundararaj S, Le Nours J, Praveena T, Cao B, Burugupalli S, Smith DGM, Patel O, Brigl M, Pellicci DG, Williams SJ, Uldrich AP, Godfrey DI, Rossjohn J. Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors. Nat Commun. 2019 11 20; 10(1):5242. PMID: 31748533.
    Citations: 8     Fields:    Translation:AnimalsCells
  6. Solomon IH, Lin C, Horback KL, Kanjilal S, Rojas-Rudilla V, Brigl M, Laga AC, Lindeman NI, Padera RF. Utility of Histologic and Histochemical Screening for 16S Ribosomal RNA Gene Sequencing of Formalin-Fixed, Paraffin-Embedded Tissue for Bacterial Endocarditis. Am J Clin Pathol. 2019 09 09; 152(4):431-437. PMID: 31172185.
    Citations: 1     Fields:    Translation:Humans
  7. Wolf BJ, Tatituri RV, Almeida CF, Le Nours J, Bhowruth V, Johnson D, Uldrich AP, Hsu FF, Brigl M, Besra GS, Rossjohn J, Godfrey DI, Brenner MB. Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells. J Immunol. 2015 Sep 15; 195(6):2540-51. PMID: 26254340; PMCID: PMC5030721.
    Citations: 25     Fields:    Translation:AnimalsCells
  8. Macho-Fernandez E, Brigl M. The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions. Front Immunol. 2015; 6:362. PMID: 26284062; PMCID: PMC4517383.
    Citations: 39     Fields:    
  9. Brennan PJ, Brigl M, Brenner MB. Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat Rev Immunol. 2013 Feb; 13(2):101-17. PMID: 23334244.
    Citations: 360     Fields:    Translation:HumansAnimalsCells
  10. Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, Brigl M. Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1827-32. PMID: 23307809.
    Citations: 70     Fields:    Translation:AnimalsCells
  11. Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB. Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nat Immunol. 2013 Jan; 14(1):90-9. PMID: 23202270.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  12. Bedel R, Matsuda JL, Brigl M, White J, Kappler J, Marrack P, Gapin L. Lower TCR repertoire diversity in Traj18-deficient mice. Nat Immunol. 2012 Jul 19; 13(8):705-6. PMID: 22814339.
    Citations: 61     Fields:    Translation:AnimalsCells
  13. Cohen NR, Tatituri RV, Rivera A, Watts GF, Kim EY, Chiba A, Fuchs BB, Mylonakis E, Besra GS, Levitz SM, Brigl M, Brenner MB. Innate recognition of cell wall ß-glucans drives invariant natural killer T cell responses against fungi. Cell Host Microbe. 2011 Nov 17; 10(5):437-50. PMID: 22100160.
    Citations: 59     Fields:    Translation:AnimalsCells
  14. Brennan PJ, Tatituri RV, Brigl M, Kim EY, Tuli A, Sanderson JP, Gadola SD, Hsu FF, Besra GS, Brenner MB. Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol. 2011 Oct 30; 12(12):1202-11. PMID: 22037601.
    Citations: 169     Fields:    Translation:HumansAnimalsCells
  15. Brigl M, Tatituri RV, Watts GF, Bhowruth V, Leadbetter EA, Barton N, Cohen NR, Hsu FF, Besra GS, Brenner MB. Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med. 2011 Jun 06; 208(6):1163-77. PMID: 21555485.
    Citations: 154     Fields:    Translation:AnimalsCells
  16. Brigl M, Brenner MB. How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens. Semin Immunol. 2010 Apr; 22(2):79-86. PMID: 19948416.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  17. Chiba A, Cohen N, Brigl M, Brennan PJ, Besra GS, Brenner MB. Rapid and reliable generation of invariant natural killer T-cell lines in vitro. Immunology. 2009 Nov; 128(3):324-33. PMID: 20067532.
    Citations: 16     Fields:    Translation:AnimalsCells
  18. Blomqvist M, Rhost S, Teneberg S, Löfbom L, Osterbye T, Brigl M, Månsson JE, Cardell SL. Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells. Eur J Immunol. 2009 Jul; 39(7):1726-35. PMID: 19582739.
    Citations: 58     Fields:    Translation:AnimalsCells
  19. Veerapen N, Brigl M, Garg S, Cerundolo V, Cox LR, Brenner MB, Besra GS. Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4288-91. PMID: 19502056.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  20. Leadbetter EA, Brigl M, Illarionov P, Cohen N, Luteran MC, Pillai S, Besra GS, Brenner MB. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8339-44. PMID: 18550809.
    Citations: 120     Fields:    Translation:AnimalsCells
  21. Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC. GATA-3 regulates the development and function of invariant NKT cells. J Immunol. 2006 Nov 15; 177(10):6650-9. PMID: 17082577.
    Citations: 65     Fields:    Translation:AnimalsCells
  22. Brigl M, van den Elzen P, Chen X, Meyers JH, Wu D, Wong CH, Reddington F, Illarianov PA, Besra GS, Brenner MB, Gumperz JE. Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors. J Immunol. 2006 Mar 15; 176(6):3625-34. PMID: 16517731.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  23. Bry L, Brigl M, Brenner MB. CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium. Infect Immun. 2006 Jan; 74(1):673-81. PMID: 16369024; PMCID: PMC1346620.
    Citations: 39     Fields:    Translation:AnimalsCells
  24. van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005 Oct 06; 437(7060):906-10. PMID: 16208376.
    Citations: 146     Fields:    Translation:HumansAnimalsCells
  25. Hava DL, Brigl M, van den Elzen P, Zajonc DM, Wilson IA, Brenner MB. CD1 assembly and the formation of CD1-antigen complexes. Curr Opin Immunol. 2005 Feb; 17(1):88-94. PMID: 15653316.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  26. Brigl M, Brenner MB. CD1: antigen presentation and T cell function. Annu Rev Immunol. 2004; 22:817-90. PMID: 15032598.
    Citations: 400     Fields:    Translation:HumansAnimalsCells
  27. Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol. 2003 Dec; 4(12):1230-7. PMID: 14578883.
    Citations: 288     Fields:    Translation:HumansAnimalsCells
  28. Berger T, Brigl M, Herrmann JM, Vielhauer V, Luckow B, Schlöndorff D, Kretzler M. The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins. J Cell Sci. 2000 Oct; 113 ( Pt 20):3603-12. PMID: 11017876.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  29. Banas B, Luckow B, Möller M, Klier C, Nelson PJ, Schadde E, Brigl M, Halevy D, Holthöfer H, Reinhart B, Schlöndorff D. Chemokine and chemokine receptor expression in a novel human mesangial cell line. J Am Soc Nephrol. 1999 Nov; 10(11):2314-22. PMID: 10541290.
    Citations: 28     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.