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Last Name

profileManfred Brigl, M.D.

TitleAssistant Professor of Pathology
InstitutionBrigham and Women's Hospital
AddressBrigham and Womens Hospital
75 Francis St
Boston MA 02115
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AI125322     (BRIGL, MANFRED)Jun 9, 2016 - May 31, 2021
MR1 and MAIT Cell Function in Intestinal Infection
Role: Principal Investigator

R21AI111039     (BRIGL, MANFRED)Apr 8, 2015 - Mar 31, 2017
Role of MR1-Restricted MAIT Cells in Intestinal Infection
Role: Principal Investigator

R21AI103616     (BRIGL, MANFRED)May 24, 2013 - Apr 30, 2015
Role of type II NKT cells during M. tuberculosis infection
Role: Principal Investigator

K08AI077795     (BRIGL, MANFRED)Feb 15, 2008 - Jan 31, 2013
CD1d-restricted NKT cells in microbial infection
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wolf BJ, Tatituri RV, Almeida CF, Le Nours J, Bhowruth V, Johnson D, Uldrich AP, Hsu FF, Brigl M, Besra GS, Rossjohn J, Godfrey DI, Brenner MB. Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells. J Immunol. 2015 Sep 15; 195(6):2540-51. PMID: 26254340.
    View in: PubMed
  2. Macho-Fernandez E, Brigl M. The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions. Front Immunol. 2015; 6:362. PMID: 26284062; PMCID: PMC4517383.
  3. Brennan PJ, Brigl M, Brenner MB. Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat Rev Immunol. 2013 Feb; 13(2):101-17. PMID: 23334244.
    View in: PubMed
  4. Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, Brigl M. Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1827-32. PMID: 23307809; PMCID: PMC3562825.
  5. Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB. Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nat Immunol. 2013 Jan; 14(1):90-9. PMID: 23202270; PMCID: PMC3764492.
  6. Bedel R, Matsuda JL, Brigl M, White J, Kappler J, Marrack P, Gapin L. Lower TCR repertoire diversity in Traj18-deficient mice. Nat Immunol. 2012 Jul 19; 13(8):705-6. PMID: 22814339; PMCID: PMC3748587.
  7. Cohen NR, Tatituri RV, Rivera A, Watts GF, Kim EY, Chiba A, Fuchs BB, Mylonakis E, Besra GS, Levitz SM, Brigl M, Brenner MB. Innate recognition of cell wall ß-glucans drives invariant natural killer T cell responses against fungi. Cell Host Microbe. 2011 Nov 17; 10(5):437-50. PMID: 22100160.
    View in: PubMed
  8. Brennan PJ, Tatituri RV, Brigl M, Kim EY, Tuli A, Sanderson JP, Gadola SD, Hsu FF, Besra GS, Brenner MB. Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol. 2011 Oct 30; 12(12):1202-11. PMID: 22037601; PMCID: PMC3242449.
  9. Brigl M, Tatituri RV, Watts GF, Bhowruth V, Leadbetter EA, Barton N, Cohen NR, Hsu FF, Besra GS, Brenner MB. Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med. 2011 Jun 06; 208(6):1163-77. PMID: 21555485; PMCID: PMC3173255.
  10. Brigl M, Brenner MB. How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens. Semin Immunol. 2010 Apr; 22(2):79-86. PMID: 19948416.
    View in: PubMed
  11. Chiba A, Cohen N, Brigl M, Brennan PJ, Besra GS, Brenner MB. Rapid and reliable generation of invariant natural killer T-cell lines in vitro. Immunology. 2009 Nov; 128(3):324-33. PMID: 20067532; PMCID: PMC2770680.
  12. Blomqvist M, Rhost S, Teneberg S, Löfbom L, Osterbye T, Brigl M, Månsson JE, Cardell SL. Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells. Eur J Immunol. 2009 Jul; 39(7):1726-35. PMID: 19582739; PMCID: PMC4212524.
  13. Veerapen N, Brigl M, Garg S, Cerundolo V, Cox LR, Brenner MB, Besra GS. Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4288-91. PMID: 19502056; PMCID: PMC2722241.
  14. Leadbetter EA, Brigl M, Illarionov P, Cohen N, Luteran MC, Pillai S, Besra GS, Brenner MB. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8339-44. PMID: 18550809; PMCID: PMC2448838.
  15. Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC. GATA-3 regulates the development and function of invariant NKT cells. J Immunol. 2006 Nov 15; 177(10):6650-9. PMID: 17082577.
    View in: PubMed
  16. Brigl M, van den Elzen P, Chen X, Meyers JH, Wu D, Wong CH, Reddington F, Illarianov PA, Besra GS, Brenner MB, Gumperz JE. Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors. J Immunol. 2006 Mar 15; 176(6):3625-34. PMID: 16517731.
    View in: PubMed
  17. Bry L, Brigl M, Brenner MB. CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium. Infect Immun. 2006 Jan; 74(1):673-81. PMID: 16369024; PMCID: PMC1346620.
  18. van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005 Oct 06; 437(7060):906-10. PMID: 16208376.
    View in: PubMed
  19. Hava DL, Brigl M, van den Elzen P, Zajonc DM, Wilson IA, Brenner MB. CD1 assembly and the formation of CD1-antigen complexes. Curr Opin Immunol. 2005 Feb; 17(1):88-94. PMID: 15653316.
    View in: PubMed
  20. Brigl M, Brenner MB. CD1: antigen presentation and T cell function. Annu Rev Immunol. 2004; 22:817-90. PMID: 15032598.
    View in: PubMed
  21. Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol. 2003 Dec; 4(12):1230-7. PMID: 14578883.
    View in: PubMed
  22. Berger T, Brigl M, Herrmann JM, Vielhauer V, Luckow B, Schlöndorff D, Kretzler M. The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins. J Cell Sci. 2000 Oct; 113 ( Pt 20):3603-12. PMID: 11017876.
    View in: PubMed
  23. Banas B, Luckow B, Möller M, Klier C, Nelson PJ, Schadde E, Brigl M, Halevy D, Holthöfer H, Reinhart B, Schlöndorff D. Chemokine and chemokine receptor expression in a novel human mesangial cell line. J Am Soc Nephrol. 1999 Nov; 10(11):2314-22. PMID: 10541290.
    View in: PubMed
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