Harvard Catalyst Profiles

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Jose Alberto Halperin, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK118528 (HALPERIN, JOSE A) Apr 1, 2019 - Mar 31, 2024
    Blood Levels of Glycated CD59, a Novel Biomarker to Assess Pregnancy-induced Glucose Intolerance
    Role: Principal Investigator
  2. R01DK101442 (HALPERIN, JOSE A) Aug 1, 2014 - Jul 31, 2020
    Human Studies on Blood Levels of Glycated CD59 as a Biomarker in Diabetes
    Role: Principal Investigator
  3. R21DK095429 (HALPERIN, JOSE A) Aug 15, 2012 - Jul 31, 2014
    Glycated CD59 as a novel biomarker of gestational diabetes mellitus
    Role: Principal Investigator
  4. R01HL107762 (HALPERIN, JOSE A) Dec 15, 2011 - Nov 30, 2017
    Glycation inactivation of human CD59 and diabetic complications
    Role: Principal Investigator
  5. R56DK089206 (HALPERIN, JOSE A) Jul 1, 2010 - Apr 30, 2012
    Glycated CD59 as a Biomarker for Diabetes
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bogdanet D, Castillo MT, Doheny H, Dervan L, Luque-Fernandez MA, Halperin JA, O'Shea PM, Dunne FP. The ability of pGCD59 to predict adverse pregnancy outcomes: a prospective study of non-diabetic pregnant women in Ireland. Acta Diabetol. 2022 Oct 29. PMID: 36309618; PMCID: PMC9617525.
    Citations:    Fields:    
  2. Bogdanet D, Luque-Fernandez MA, Toth-Castillo M, Desoye G, O'Shea PM, Dunne FP, Halperin JA. The role of early pregnancy maternal pGCD59 levels in predicting neonatal hypoglycaemia- sub-analysis of the DALI study. J Clin Endocrinol Metab. 2022 Sep 02. PMID: 36054347.
    Citations:    Fields:    
  3. Bogdanet D, Toth Castillo M, Doheny H, Dervan L, Angel Luque-Fernandez M, Halperin J, O'Shea PM, Dunne FP. The utility of first trimester plasma glycated CD59 (pGCD59) in predicting gestational diabetes mellitus: A prospective study of non-diabetic pregnant women in Ireland. Diabetes Res Clin Pract. 2022 Aug; 190:110023. PMID: 35907507; PMCID: PMC9483034.
    Citations:    Fields:    Translation:Humans
  4. Bogdanet D, Toth Castillo M, Doheny H, Dervan L, Luque-Fernandez MA, Halperin JA, O'Shea PM, Dunne FP. The Diagnostic Accuracy of Second Trimester Plasma Glycated CD59 (pGCD59) to Identify Women with Gestational Diabetes Mellitus Based on the 75 g OGTT Using the WHO Criteria: A Prospective Study of Non-Diabetic Pregnant Women in Ireland. J Clin Med. 2022 Jul 04; 11(13). PMID: 35807179; PMCID: PMC9267743.
  5. Andrews C, Toth-Castillo M, Aktas H, Fernandez ML, Wong SK, Sen S, Halperin J. Plasma-glycated CD59 as an early biomarker for gestational diabetes mellitus: prospective cohort study protocol. BMJ Open. 2022 04 20; 12(4):e054773. PMID: 35443950; PMCID: PMC9021770.
    Citations:    Fields:    Translation:Humans
  6. Benhalima K, Ma DD, Laenen A, Mathieu C, Halperin JA. Plasma glycated CD59 predicts postpartum glucose intolerance after gestational diabetes. Eur J Endocrinol. 2021 Oct 11; 185(5):755-763. PMID: 34524975; PMCID: PMC8511340.
    Citations:    Fields:    Translation:Humans
  7. Bogdanet D, Reddin C, Murphy D, Doheny HC, Halperin JA, Dunne F, O'Shea PM. Emerging Protein Biomarkers for the Diagnosis or Prediction of Gestational Diabetes-A Scoping Review. J Clin Med. 2021 Apr 06; 10(7). PMID: 33917484.
    Citations: 5     
  8. Meek CL, Tundidor D, Feig DS, Yamamoto JM, Scott EM, Ma DD, Halperin JA, Murphy HR, Corcoy R. Novel Biochemical Markers of Glycemia to Predict Pregnancy Outcomes in Women With Type 1 Diabetes. Diabetes Care. 2021 03; 44(3):681-689. PMID: 33495292; PMCID: PMC8051277.
    Citations: 3     Fields:    Translation:Humans
  9. Ma D, Luque-Fernandez MA, Bogdanet D, Desoye G, Dunne F, Halperin JA. Plasma Glycated CD59 Predicts Early Gestational Diabetes and Large for Gestational Age Newborns. J Clin Endocrinol Metab. 2020 04 01; 105(4). PMID: 32069353; PMCID: PMC7082084.
    Citations: 13     Fields:    Translation:HumansCells
  10. Zhang Q, Du R, Reis Monteiro Dos Santos GR, Yefidoff-Freedman R, Bohm A, Halperin J, Chorev M, Aktas BH. New activators of eIF2a Kinase Heme-Regulated Inhibitor (HRI) with improved biophysical properties. Eur J Med Chem. 2020 Feb 01; 187:111973. PMID: 31881453.
    Citations: 4     Fields:    Translation:HumansCells
  11. Sahoo R, Ghosh P, Chorev M, Halperin JA. A distinctive histidine residue is essential for in vivo glycation-inactivation of human CD59 transgenically expressed in mice erythrocytes: Implications for human diabetes complications. Am J Hematol. 2017 Nov; 92(11):1198-1203. PMID: 28815695.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. Yefidoff-Freedman R, Fan J, Yan L, Zhang Q, Dos Santos GRR, Rana S, Contreras JI, Sahoo R, Wan D, Young J, Dias Teixeira KL, Morisseau C, Halperin J, Hammock B, Natarajan A, Wang P, Chorev M, Aktas BH. Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2a) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response. J Med Chem. 2017 07 13; 60(13):5392-5406. PMID: 28590739; PMCID: PMC5567831.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  13. Ghosh P, Luque-Fernandez MA, Vaidya A, Ma D, Sahoo R, Chorev M, Zera C, McElrath TF, Williams MA, Seely EW, Halperin JA. Plasma Glycated CD59, a Novel Biomarker for Detection of Pregnancy-Induced Glucose Intolerance. Diabetes Care. 2017 07; 40(7):981-984. PMID: 28450368.
    Citations: 12     Fields:    Translation:Humans
  14. Liu F, Sahoo R, Ge X, Wu L, Ghosh P, Qin X, Halperin JA. Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice. J Diabetes Complications. 2017 Feb; 31(2):311-317. PMID: 27729184; PMCID: PMC5460985.
    Citations: 8     Fields:    Translation:Animals
  15. Ghosh P, Sahoo R, Vaidya A, Chorev M, Halperin JA. Role of complement and complement regulatory proteins in the complications of diabetes. Endocr Rev. 2015 Jun; 36(3):272-88. PMID: 25859860; PMCID: PMC4446516.
    Citations: 47     Fields:    Translation:HumansAnimals
  16. Aktas BH, Bordelois P, Peker S, Merajver S, Halperin JA. Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo. Oncotarget. 2015 Mar 30; 6(9):6902-14. PMID: 25762631.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  17. Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G. Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3187-95. PMID: 25049413.
    Citations: 36     Fields:    Translation:HumansCells
  18. Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M. Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction. J Med Chem. 2014 Jun 26; 57(12):5094-111. PMID: 24827861.
    Citations: 9     Fields:    Translation:HumansCells
  19. Ghosh P, Vaidya A, Sahoo R, Goldfine A, Herring N, Bry L, Chorev M, Halperin JA. Glycation of the complement regulatory protein CD59 is a novel biomarker for glucose handling in humans. J Clin Endocrinol Metab. 2014 Jun; 99(6):E999-E1006. PMID: 24628556; PMCID: PMC4037733.
    Citations: 20     Fields:    Translation:HumansCellsCTClinical Trials
  20. Takrouri K, Chen T, Papadopoulos E, Sahoo R, Kabha E, Chen H, Cantel S, Wagner G, Halperin JA, Aktas BH, Chorev M. Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors. Eur J Med Chem. 2014 Apr 22; 77:361-77. PMID: 24675136.
    Citations: 4     Fields:    Translation:HumansCells
  21. Yefidoff-Freedman R, Chen T, Sahoo R, Chen L, Wagner G, Halperin JA, Aktas BH, Chorev M. 3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction. Chembiochem. 2014 Mar 03; 15(4):595-611. PMID: 24458973.
    Citations: 3     Fields:    Translation:HumansCells
  22. Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock B, Chorev M, Aktas BH. Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase. J Med Chem. 2013 Dec 12; 56(23):9457-70. PMID: 24261904.
    Citations: 12     Fields:    Translation:HumansCells
  23. Aktas BH, Qiao Y, Ozdelen E, Schubert R, Sevinc S, Harbinski F, Grubissich L, Singer S, Halperin JA. Small-Molecule targeting of translation initiation for cancer therapy. Oncotarget. 2013 Oct; 4(10):1606-17. PMID: 24091475.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  24. Ghosh P, Sahoo R, Vaidya A, Cantel S, Kavishwar A, Goldfine A, Herring N, Bry L, Chorev M, Halperin JA. A specific and sensitive assay for blood levels of glycated CD59: a novel biomarker for diabetes. Am J Hematol. 2013 Aug; 88(8):670-6. PMID: 23670858.
    Citations: 19     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  25. Kusner LL, Halperin JA, Kaminski HJ. Cell surface complement regulators moderate experimental myasthenia gravis pathology. Muscle Nerve. 2013 Jan; 47(1):33-40. PMID: 23042232.
    Citations: 10     Fields:    Translation:AnimalsCells
  26. Chen L, Aktas BH, Wang Y, He X, Sahoo R, Zhang N, Denoyelle S, Kabha E, Yang H, Freedman RY, Supko JG, Chorev M, Wagner G, Halperin JA. Tumor suppression by small molecule inhibitors of translation initiation. Oncotarget. 2012 Aug; 3(8):869-81. PMID: 22935625.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  27. Soltys J, Halperin JA, Xuebin Q. DAF/CD55 and Protectin/CD59 modulate adaptive immunity and disease outcome in experimental autoimmune myasthenia gravis. J Neuroimmunol. 2012 Mar; 244(1-2):63-9. PMID: 22325826.
    Citations: 6     Fields:    Translation:AnimalsCells
  28. Chen T, Ozel D, Qiao Y, Harbinski F, Chen L, Denoyelle S, He X, Zvereva N, Supko JG, Chorev M, Halperin JA, Aktas BH. Chemical genetics identify eIF2a kinase heme-regulated inhibitor as an anticancer target. Nat Chem Biol. 2011 Jul 17; 7(9):610-6. PMID: 21765405.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  29. Hu W, Ge X, You T, Xu T, Zhang J, Wu G, Peng Z, Chorev M, Aktas BH, Halperin JA, Brown JR, Qin X. Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis. Cancer Res. 2011 Mar 15; 71(6):2298-307. PMID: 21252115.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  30. Hu W, Jin R, Zhang J, You T, Peng Z, Ge X, Bronson RT, Halperin JA, Loscalzo J, Qin X. The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model. Blood. 2010 Sep 02; 116(9):1613-22. PMID: 20511540; PMCID: PMC2938847.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  31. Wu G, Chen T, Shahsafaei A, Hu W, Bronson RT, Shi GP, Halperin JA, Aktas H, Qin X. Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. Circulation. 2010 Mar 23; 121(11):1338-46. PMID: 20212283; PMCID: PMC3057574.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  32. Hu W, Yu Q, Hu N, Byrd D, Amet T, Shikuma C, Shiramizu B, Halperin JA, Qin X. A high-affinity inhibitor of human CD59 enhances complement-mediated virolysis of HIV-1: implications for treatment of HIV-1/AIDS. J Immunol. 2010 Jan 01; 184(1):359-68. PMID: 19955519; PMCID: PMC4272871.
    Citations: 26     Fields:    Translation:HumansCells
  33. Qin X, Hu W, Song W, Blair P, Wu G, Hu X, Song Y, Bauer S, Feelisch M, Leopold JA, Loscalzo J, Halperin JA. Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009 Apr; 84(4):221-7. PMID: 19229985.
    Citations: 12     Fields:    Translation:AnimalsCells
  34. Carganico S, Rovero P, Halperin JA, Papini AM, Chorev M. Building blocks for the synthesis of post-translationally modified glycated peptides and proteins. J Pept Sci. 2009 Feb; 15(2):67-71. PMID: 19090529.
    Citations: 4     Fields:    Translation:Cells
  35. Qin X, Hu W, Song W, Grubissich L, Hu X, Wu G, Ferris S, Dobarro M, Halperin JA. Generation and phenotyping of mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009 Feb; 84(2):65-70. PMID: 19051264.
    Citations: 17     Fields:    Translation:AnimalsCells
  36. Wu G, Hu W, Shahsafaei A, Song W, Dobarro M, Sukhova GK, Bronson RR, Shi GP, Rother RP, Halperin JA, Qin X. Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. Circ Res. 2009 Feb 27; 104(4):550-8. PMID: 19131645.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  37. Cantel S, Kavishwar A, Schlimme M, Khatri A, Halperin JA, Chorev M. Glycated-CD59 antigen: exploration of synthetic approaches. Adv Exp Med Biol. 2009; 611:317-8. PMID: 19400208.
    Citations: 1     Fields:    Translation:Humans
  38. Cantel S, Halperin JA, Chorev M, Scrima M, D'Ursi AM, Levy JJ, DiMarchi RD, Le Chevalier A, Rovero P, Papini AM. Side chain-to-side chain cyclization by intramolecular click reaction--building blocks, solid phase synthesis and conformational characterization. Adv Exp Med Biol. 2009; 611:175-6. PMID: 19400147.
    Citations:    Fields:    Translation:Cells
  39. Cantel S, Isaad Ale C, Scrima M, Levy JJ, DiMarchi RD, Rovero P, Halperin JA, D'Ursi AM, Papini AM, Chorev M. Synthesis and conformational analysis of a cyclic peptide obtained via i to i+4 intramolecular side-chain to side-chain azide-alkyne 1,3-dipolar cycloaddition. J Org Chem. 2008 Aug 01; 73(15):5663-74. PMID: 18489158.
    Citations: 30     Fields:    Translation:Cells
  40. Hu W, Ferris SP, Tweten RK, Wu G, Radaeva S, Gao B, Bronson RT, Halperin JA, Qin X. Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin. Nat Med. 2008 Jan; 14(1):98-103. PMID: 18157141.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  41. Hyberts SG, Heffron GJ, Tarragona NG, Solanky K, Edmonds KA, Luithardt H, Fejzo J, Chorev M, Aktas H, Colson K, Falchuk KH, Halperin JA, Wagner G. Ultrahigh-resolution (1)H-(13)C HSQC spectra of metabolite mixtures using nonlinear sampling and forward maximum entropy reconstruction. J Am Chem Soc. 2007 Apr 25; 129(16):5108-16. PMID: 17388596; PMCID: PMC2631400.
    Citations: 60     Fields:    Translation:AnimalsCells
  42. Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007 Jan 26; 128(2):257-67. PMID: 17254965.
    Citations: 259     Fields:    Translation:HumansAnimalsCells
  43. Gelev V, Aktas H, Marintchev A, Ito T, Frueh D, Hemond M, Rovnyak D, Debus M, Hyberts S, Usheva A, Halperin J, Wagner G. Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance. J Mol Biol. 2006 Dec 01; 364(3):352-63. PMID: 17011579; PMCID: PMC3622519.
    Citations: 21     Fields:    Translation:Cells
  44. Qin X, Ferris S, Hu W, Guo F, Ziegeler G, Halperin JA. Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes. Genes Immun. 2006 Jun; 7(4):287-97. PMID: 16541098.
    Citations: 7     Fields:    Translation:AnimalsCells
  45. Qin X, Dobarro M, Bedford SJ, Ferris S, Miranda PV, Song W, Bronson RT, Visconti PE, Halperin JA. Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction. J Immunol. 2005 Nov 15; 175(10):6294-302. PMID: 16272280.
    Citations: 12     Fields:    Translation:AnimalsCells
  46. Natarajan A, Guo Y, Arthanari H, Wagner G, Halperin JA, Chorev M. Synthetic studies toward aryl-(4-aryl-4H-[1,2,4]triazole-3-yl)-amine from 1,3-diarylthiourea as urea mimetics. J Org Chem. 2005 Aug 05; 70(16):6362-8. PMID: 16050698; PMCID: PMC3258527.
    Citations: 4     Fields:    Translation:Cells
  47. Chen H, Fan YH, Natarajan A, Guo Y, Iyasere J, Harbinski F, Luus L, Christ W, Aktas H, Halperin JA. Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation. Bioorg Med Chem Lett. 2004 Nov 01; 14(21):5401-5. PMID: 15454234.
    Citations: 8     Fields:    Translation:HumansCells
  48. Natarajan A, Guo Y, Harbinski F, Fan YH, Chen H, Luus L, Diercks J, Aktas H, Chorev M, Halperin JA. Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation. J Med Chem. 2004 Oct 07; 47(21):4979-82. PMID: 15456240.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  49. Qin X, Goldfine A, Krumrei N, Grubissich L, Acosta J, Chorev M, Hays AP, Halperin JA. Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes. Diabetes. 2004 Oct; 53(10):2653-61. PMID: 15448097.
    Citations: 65     Fields:    Translation:HumansCells
  50. Aktas H, Halperin JA. Translational regulation of gene expression by omega-3 fatty acids. J Nutr. 2004 Sep; 134(9):2487S-2491S. PMID: 15333747.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  51. Fan YH, Chen H, Natarajan A, Guo Y, Harbinski F, Iyasere J, Christ W, Aktas H, Halperin JA. Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium. Bioorg Med Chem Lett. 2004 May 17; 14(10):2547-50. PMID: 15109648.
    Citations: 6     Fields:    Translation:HumansCells
  52. Natarajan A, Moerke N, Fan YH, Chen H, Christ WJ, Wagner G, Halperin JA. Synthesis of fluorescein labeled 7-methylguanosinemonophosphate. Bioorg Med Chem Lett. 2004 May 17; 14(10):2657-60. PMID: 15109672.
    Citations: 4     Fields:    Translation:HumansCells
  53. Natarajan A, Fan YH, Chen H, Guo Y, Iyasere J, Harbinski F, Christ WJ, Aktas H, Halperin JA. 3,3-diaryl-1,3-dihydroindol-2-ones as antiproliferatives mediated by translation initiation inhibition. J Med Chem. 2004 Apr 08; 47(8):1882-5. PMID: 15055987.
    Citations: 8     Fields:    Translation:HumansCells
  54. Acosta J, Qin X, Halperin J. Complement and complement regulatory proteins as potential molecular targets for vascular diseases. Curr Pharm Des. 2004; 10(2):203-11. PMID: 14754399.
    Citations: 25     Fields:    Translation:HumansAnimals
  55. Qin X, Krumrei N, Grubissich L, Dobarro M, Aktas H, Perez G, Halperin JA. Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility. Immunity. 2003 Feb; 18(2):217-27. PMID: 12594949.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  56. Palakurthi SS, Aktas H, Grubissich LM, Mortensen RM, Halperin JA. Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation. Cancer Res. 2001 Aug 15; 61(16):6213-8. PMID: 11507074.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  57. Qin X, Miwa T, Aktas H, Gao M, Lee C, Qian YM, Morton CC, Shahsafaei A, Song WC, Halperin JA. Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b. Mamm Genome. 2001 Aug; 12(8):582-9. PMID: 11471050.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  58. Qian YM, Qin X, Miwa T, Sun X, Halperin JA, Song WC. Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59. J Immunol. 2000 Sep 01; 165(5):2528-34. PMID: 10946279.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  59. Palakurthi SS, Flückiger R, Aktas H, Changolkar AK, Shahsafaei A, Harneit S, Kilic E, Halperin JA. Inhibition of translation initiation mediates the anticancer effect of the n-3 polyunsaturated fatty acid eicosapentaenoic acid. Cancer Res. 2000 Jun 01; 60(11):2919-25. PMID: 10850438.
    Citations: 25     Fields:    Translation:AnimalsCells
  60. Acosta J, Hettinga J, Flückiger R, Krumrei N, Goldfine A, Angarita L, Halperin J. Molecular basis for a link between complement and the vascular complications of diabetes. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5450-5. PMID: 10805801; PMCID: PMC25849.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  61. Aktas H, Flückiger R, Acosta JA, Savage JM, Palakurthi SS, Halperin JA. Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):8280-5. PMID: 9653178; PMCID: PMC20967.
    Citations: 31     Fields:    Translation:AnimalsCells
  62. Shen Y, Halperin JA, Benzaquen L, Lee CM. Characterization of neuronal cell death induced by complement activation. Brain Res Brain Res Protoc. 1997 May; 1(2):186-94. PMID: 9385083.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  63. Acosta JA, Benzaquen LR, Goldstein DJ, Tosteson MT, Halperin JA. The transient pore formed by homologous terminal complement complexes functions as a bidirectional route for the transport of autocrine and paracrine signals across human cell membranes. Mol Med. 1996 Nov; 2(6):755-65. PMID: 8972490; PMCID: PMC2230132.
    Citations: 10     Fields:    Translation:HumansCells
  64. Benzaquen LR, Brugnara C, Byers HR, Gatton-Celli S, Halperin JA. Clotrimazole inhibits cell proliferation in vitro and in vivo. Nat Med. 1995 Jun; 1(6):534-40. PMID: 7585119.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  65. Shen Y, Halperin JA, Lee CM. Complement-mediated neurotoxicity is regulated by homologous restriction. Brain Res. 1995 Feb 13; 671(2):282-92. PMID: 7743216.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  66. Benzaquen LR, Nicholson-Weller A, Halperin JA. Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells. J Exp Med. 1994 Mar 01; 179(3):985-92. PMID: 8113689; PMCID: PMC2191420.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  67. Berger HJ, Taratuska A, Smith TW, Halperin JA. Activated complement directly modifies the performance of isolated heart muscle cells from guinea pig and rat. Am J Physiol. 1993 Jul; 265(1 Pt 2):H267-72. PMID: 8342642.
    Citations: 8     Fields:    Translation:AnimalsCells
  68. Halperin JA, Taratuska A, Nicholson-Weller A. Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells. J Clin Invest. 1993 May; 91(5):1974-8. PMID: 8486768; PMCID: PMC288194.
    Citations: 40     Fields:    Translation:AnimalsCells
  69. Halperin JA, Taratuska A, Rynkiewicz M, Nicholson-Weller A. Transient changes in erythrocyte membrane permeability are induced by sublytic amounts of the complement membrane attack complex (C5b-9). Blood. 1993 Jan 01; 81(1):200-5. PMID: 7678066.
    Citations: 9     Fields:    Translation:HumansCells
  70. Nicholson-Weller A, Halperin JA. Membrane signaling by complement C5b-9, the membrane attack complex. Immunol Res. 1993; 12(3):244-57. PMID: 8288945.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  71. Halperin JA, Cornelius F. A voltage-activated cation transport pathway associated with the sodium pump. Biochim Biophys Acta. 1991 Dec 09; 1070(2):497-500. PMID: 1662540.
    Citations:    Fields:    Translation:AnimalsCells
  72. Tosteson MT, Halperin JA, Kishi Y, Tosteson DC. Palytoxin induces an increase in the cation conductance of red cells. J Gen Physiol. 1991 Nov; 98(5):969-85. PMID: 1684984; PMCID: PMC2229094.
    Citations: 14     Fields:    Translation:HumansCells
  73. Halperin JA, Brugnara C, Van Ha T, Tosteson DC. Voltage-activated cation permeability in high-potassium but not low-potassium red blood cells. Am J Physiol. 1990 Jun; 258(6 Pt 1):C1169-72. PMID: 1694398.
    Citations: 5     Fields:    Translation:AnimalsCells
  74. Lorenzo AV, Taratuska A, Halperin JA. Suppression of cerebrospinal fluid (CSF) production by a Na+/K+ pump inhibitor extracted from human cerebrospinal fluid. Z Kinderchir. 1989 Dec; 44 Suppl 1:24-6. PMID: 2560297.
    Citations: 1     Fields:    Translation:Animals
  75. Halperin JA, Brugnara C, Tosteson MT, Van Ha T, Tosteson DC. Voltage-activated cation transport in human erythrocytes. Am J Physiol. 1989 Nov; 257(5 Pt 1):C986-96. PMID: 2596592.
    Citations: 18     Fields:    Translation:HumansCells
  76. Halperin JA, Brugnara C, Nicholson-Weller A. Ca2+-activated K+ efflux limits complement-mediated lysis of human erythrocytes. J Clin Invest. 1989 May; 83(5):1466-71. PMID: 2708520; PMCID: PMC303848.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  77. Halperin JA. Digitalis-like properties of an inhibitor of the Na+/K+ pump in human cerebrospinal fluid. J Neurol Sci. 1989 Apr; 90(2):217-30. PMID: 2542468.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  78. Nicholson-Weller A, Halperin JA. Mechanisms by which the erythrocyte protects itself from complement damage. Prog Clin Biol Res. 1989; 297:263-70; discussion 270-1. PMID: 2479950.
    Citations:    Fields:    Translation:HumansCells
  79. Halperin JA, Nicholson-Weller A. Paroxysmal nocturnal hemoglobinuria. A complement-mediated disease. Complement Inflamm. 1989; 6(1):65-72. PMID: 2650991.
    Citations: 4     Fields:    Translation:Humans
  80. Halperin JA, Nicholson-Weller A, Brugnara C, Tosteson DC. Complement induces a transient increase in membrane permeability in unlysed erythrocytes. J Clin Invest. 1988 Aug; 82(2):594-600. PMID: 3403718; PMCID: PMC303553.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  81. Halperin JA, Riordan JF, Tosteson DC. Characteristics of an inhibitor of the Na+/K+ pump in human cerebrospinal fluid. J Biol Chem. 1988 Jan 15; 263(2):646-51. PMID: 2826458.
    Citations: 4     Fields:    Translation:HumansCells
  82. Halperin JA, Brugnara C, Kopin AS, Ingwall J, Tosteson DC. Properties of the Na+-K+ pump in human red cells with increased number of pump sites. J Clin Invest. 1987 Jul; 80(1):128-37. PMID: 2439543; PMCID: PMC442210.
    Citations: 6     Fields:    Translation:HumansCells
  83. Halperin JA, Lobb RR. Effect of heparin-binding growth factors on monovalent cation transport in Balb/C 3T3 cells. Biochem Biophys Res Commun. 1987 Apr 14; 144(1):115-22. PMID: 2437904.
    Citations:    Fields:    Translation:AnimalsCells
  84. Halperin JA, Martin AM, Malave S. Increased digitalis-like activity in human cerebrospinal fluid after expansion of the extracellular fluid volume. Life Sci. 1985 Aug 12; 37(6):561-6. PMID: 2991687.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  85. Goldstein DJ, Marante Perez DJ, Gunst JP, Halperin JA. Prostaglandin E1 inhibits acute cell dehydration thirst. Pharmacol Biochem Behav. 1979 Jun; 10(6):895-8. PMID: 482310.
    Citations: 1     Fields:    Translation:AnimalsCells
  86. Goldstein DJ, Pérez DJ, Gunst JP, Halperin JA. Increase in mast cell number and altered vascular permeability in thirsty rats. Life Sci. 1978 Oct 16; 23(15):1591-601. PMID: 82897.
    Citations:    Fields:    Translation:AnimalsCells
  87. Goldstein DJ, Halperin JA. Mast cell histamine and cell dehydration thirst. Nature. 1977 May 19; 267(5608):250-2. PMID: 405619.
    Citations: 4     Fields:    Translation:AnimalsCells
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