Harvard Catalyst Profiles

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M. Amin Arnaout, M.D.

Concepts

This page shows the publications M. Arnaout has written about Humans.
Connection Strength

0.227
  1. Structure-guided design of pure orthosteric inhibitors of aIIbß3 that prevent thrombosis but preserve hemostasis. Nat Commun. 2020 01 21; 11(1):398.
    View in: PubMed
    Score: 0.010
  2. Structural Basis of the Differential Binding of Engineered Knottins to Integrins aVß3 and a5ß1. Structure. 2019 09 03; 27(9):1443-1451.e6.
    View in: PubMed
    Score: 0.010
  3. The a-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in ß3 integrins. J Biol Chem. 2014 Aug 15; 289(33):23256-23263.
    View in: PubMed
    Score: 0.007
  4. Atomic basis for the species-specific inhibition of aV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of aVß3 ectodomain-17E6 Fab complex. J Biol Chem. 2014 May 16; 289(20):13801-9.
    View in: PubMed
    Score: 0.007
  5. Structural basis for pure antagonism of integrin aVß3 by a high-affinity form of fibronectin. Nat Struct Mol Biol. 2014 Apr; 21(4):383-8.
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    Score: 0.007
  6. EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane. PLoS One. 2013; 8(2):e57951.
    View in: PubMed
    Score: 0.006
  7. Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J Immunol. 2011 Dec 15; 187(12):6393-401.
    View in: PubMed
    Score: 0.006
  8. Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment. J Cell Biol. 2009 Aug 24; 186(4):589-600.
    View in: PubMed
    Score: 0.005
  9. Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function. J Immunol. 2008 Feb 01; 180(3):1713-8.
    View in: PubMed
    Score: 0.004
  10. A case management model to improve hemodialysis outpatient outcomes. Hemodial Int. 2007 Apr; 11(2):247-51.
    View in: PubMed
    Score: 0.004
  11. Purification, analysis, and crystal structure of integrins. Methods Enzymol. 2007; 426:307-36.
    View in: PubMed
    Score: 0.004
  12. The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood. 2007 Apr 15; 109(8):3513-20.
    View in: PubMed
    Score: 0.004
  13. The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells. Development. 2006 Sep; 133(18):3641-50.
    View in: PubMed
    Score: 0.004
  14. Integrin structure, allostery, and bidirectional signaling. Annu Rev Cell Dev Biol. 2005; 21:381-410.
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    Score: 0.004
  15. A novel adaptation of the integrin PSI domain revealed from its crystal structure. J Biol Chem. 2004 Sep 24; 279(39):40252-4.
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    Score: 0.003
  16. The structural basis of elasticity in fibrillin-based microfibrils. Structure. 2004 May; 12(5):734-6.
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    Score: 0.003
  17. Integrins, cations and ligands: making the connection. J Thromb Haemost. 2003 Jul; 1(7):1642-54.
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    Score: 0.003
  18. New insights into the structural basis of integrin activation. Blood. 2003 Aug 15; 102(4):1155-9.
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    Score: 0.003
  19. Coming to grips with integrin binding to ligands. Curr Opin Cell Biol. 2002 Oct; 14(5):641-51.
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    Score: 0.003
  20. The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene. Blood. 2003 Feb 01; 101(3):894-902.
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    Score: 0.003
  21. Integrin structure: new twists and turns in dynamic cell adhesion. Immunol Rev. 2002 Aug; 186:125-40.
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    Score: 0.003
  22. Does the integrin alphaA domain act as a ligand for its betaA domain? Curr Biol. 2002 May 14; 12(10):R340-2.
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    Score: 0.003
  23. During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter. J Immunol. 2002 Apr 15; 168(8):3887-93.
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    Score: 0.003
  24. Characterization of a conformationally sensitive murine monoclonal antibody directed to the metal ion-dependent adhesion site face of integrin CD11b. J Immunol. 2002 Feb 01; 168(3):1219-25.
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    Score: 0.003
  25. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Genomics. 2002 Jan; 79(1):87-94.
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    Score: 0.003
  26. Polycystin-1 interacts with intermediate filaments. J Biol Chem. 2001 Dec 07; 276(49):46544-52.
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    Score: 0.003
  27. Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science. 2001 Oct 12; 294(5541):339-45.
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    Score: 0.003
  28. Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease. Annu Rev Med. 2001; 52:93-123.
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    Score: 0.003
  29. An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain. J Biol Chem. 2000 Dec 08; 275(49):38762-7.
    View in: PubMed
    Score: 0.003
  30. The vasculopathy of autosomal dominant polycystic kidney disease: insights from animal models. Kidney Int. 2000 Dec; 58(6):2599-610.
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    Score: 0.003
  31. Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1731-6.
    View in: PubMed
    Score: 0.003
  32. uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. J Clin Invest. 2019 04 02; 129(5):1946-1959.
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    Score: 0.002
  33. Interaction of purified human proteinase 3 (PR3) with reconstituted lipid bilayers. Eur J Biochem. 1999 Apr; 261(1):155-62.
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    Score: 0.002
  34. High-Affinity Bent ß2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis. Cell Rep. 2019 01 02; 26(1):119-130.e5.
    View in: PubMed
    Score: 0.002
  35. Functional analysis of the beta 2 integrins. Methods Mol Biol. 1999; 129:105-24.
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    Score: 0.002
  36. Two functional states of the CD11b A-domain: correlations with key features of two Mn2+-complexed crystal structures. J Cell Biol. 1998 Dec 14; 143(6):1523-34.
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    Score: 0.002
  37. Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb. Genomics. 1998 Apr 15; 49(2):334-6.
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    Score: 0.002
  38. A microfluidic renal proximal tubule with active reabsorptive function. PLoS One. 2017; 12(10):e0184330.
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    Score: 0.002
  39. Emerging paradigms of integrin ligand binding and activation. Kidney Int. 1997 May; 51(5):1454-62.
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    Score: 0.002
  40. Integrin-ligand interactions: scratching the surface. Curr Opin Hematol. 1997 Jan; 4(1):67-74.
    View in: PubMed
    Score: 0.002
  41. Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2. J Immunol. 1996 Dec 15; 157(12):5597-605.
    View in: PubMed
    Score: 0.002
  42. Characterization and cell distribution of polycystin, the product of autosomal dominant polycystic kidney disease gene 1. Mol Med. 1996 Nov; 2(6):702-11.
    View in: PubMed
    Score: 0.002
  43. Solvent-accessible residues on the metal ion-dependent adhesion site face of integrin CR3 mediate its binding to the neutrophil inhibitory factor. J Biol Chem. 1996 Jul 05; 271(27):15858-61.
    View in: PubMed
    Score: 0.002
  44. Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB J. 2015 Dec; 29(12):4989-5005.
    View in: PubMed
    Score: 0.002
  45. Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis. Kidney Int. 1995 Jun; 47(6):1528-36.
    View in: PubMed
    Score: 0.002
  46. Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18. J Immunol. 1995 Apr 01; 154(7):3461-70.
    View in: PubMed
    Score: 0.002
  47. The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF. J Cell Biol. 1994 Dec; 127(6 Pt 2):2081-91.
    View in: PubMed
    Score: 0.002
  48. Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18). Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10680-4.
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    Score: 0.002
  49. The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements. Mol Cell Biol. 1994 Apr; 14(4):2604-15.
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    Score: 0.002
  50. Structure of the kidney slit diaphragm adapter protein CD2-associated protein as determined with electron microscopy. J Am Soc Nephrol. 2014 Jul; 25(7):1465-73.
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    Score: 0.002
  51. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2013 Dec 19; 369(25):2416-23.
    View in: PubMed
    Score: 0.002
  52. Cytoplasmic tails of human complement receptor type 3 (CR3, CD11b/CD18) regulate ligand avidity and the internalization of occupied receptors. J Immunol. 1993 Jul 15; 151(2):990-1002.
    View in: PubMed
    Score: 0.002
  53. Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5. J Immunol. 1993 Jul 15; 151(2):810-3.
    View in: PubMed
    Score: 0.002
  54. Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5364-8.
    View in: PubMed
    Score: 0.002
  55. Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers. Lab Chip. 2013 Jun 21; 13(12):2311-9.
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    Score: 0.002
  56. Cell adhesion molecules in inflammation and thrombosis: status and prospects. Am J Kidney Dis. 1993 Jan; 21(1):72-6.
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    Score: 0.002
  57. Antineutrophil cytoplasmic autoantibody-associated vasculitis presenting as Sjögren's syndrome. Arthritis Rheum. 1992 Nov; 35(11):1373-6.
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    Score: 0.002
  58. Wegener granulomatosis. Ann Intern Med. 1992 Oct 01; 117(7):620; author reply 620-1.
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    Score: 0.002
  59. Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins. J Biol Chem. 1992 Feb 15; 267(5):3351-7.
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    Score: 0.001
  60. The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10525-9.
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    Score: 0.001
  61. Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3106-10.
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    Score: 0.001
  62. Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin. Blood. 1990 Nov 15; 76(10):2162.
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    Score: 0.001
  63. The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. Prostaglandins Leukot Essent Fatty Acids. 2011 Jan-Feb; 84(1-2):43-50.
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    Score: 0.001
  64. Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response. Immunol Rev. 1990 Apr; 114:145-80.
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    Score: 0.001
  65. Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency. J Clin Invest. 1990 Mar; 85(3):977-81.
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    Score: 0.001
  66. Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules. J Cell Biol. 1989 Dec; 109(6 Pt 2):3435-44.
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    Score: 0.001
  67. Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase. Blood. 1989 Nov 01; 74(6):1888-93.
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    Score: 0.001
  68. The relationship between CR3 deficiency and neutrophil actin assembly. Blood. 1989 May 15; 73(7):1973-9.
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    Score: 0.001
  69. Relative contribution of the leukocyte molecules Mo1, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific. J Cell Physiol. 1988 Nov; 137(2):305-9.
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    Score: 0.001
  70. Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3). J Cell Biol. 1988 Jun; 106(6):2153-8.
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    Score: 0.001
  71. Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2776-80.
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    Score: 0.001
  72. A dysfunctional Mo1 glycoprotein is present on a subline of the KG1 acute myelogenous leukemia cell line. J Immunol. 1987 May 15; 138(10):3549-54.
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    Score: 0.001
  73. A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. J Biomol Screen. 2007 Apr; 12(3):406-17.
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    Score: 0.001
  74. Leukocytes from four patients with complete or partial Leu-CAM deficiency contain the common beta-subunit precursor and beta-subunit messenger RNA. J Clin Invest. 1987 Mar; 79(3):1010-5.
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    Score: 0.001
  75. Human complement receptor type 3. Methods Enzymol. 1987; 150:602-15.
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    Score: 0.001
  76. N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa. Biochim Biophys Acta. 1986 Dec 12; 874(3):368-71.
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    Score: 0.001
  77. Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies. J Immunol. 1986 Nov 15; 137(10):3259-63.
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    Score: 0.001
  78. Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes. J Clin Invest. 1986 Aug; 78(2):597-601.
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    Score: 0.001
  79. Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli. Protein Expr Purif. 2006 Sep; 49(1):121-8.
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    Score: 0.001
  80. Mo1 surface glycoprotein: structure, function and clinical importance. Pathol Immunopathol Res. 1986; 5(3-5):371-83.
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    Score: 0.001
  81. Deficiency of two human leukocyte surface membrane glycoproteins (Mo1 and LFA-1). Fed Proc. 1985 Jul; 44(10):2664-70.
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    Score: 0.001
  82. The modulated expression of Mo5, a human myelomonocytic plasma membrane antigen. Blood. 1985 Apr; 65(4):964-73.
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    Score: 0.001
  83. Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin. J Cell Biol. 2005 Mar 28; 168(7):1109-18.
    View in: PubMed
    Score: 0.001
  84. Increased expression of an adhesion-promoting surface glycoprotein in the granulocytopenia of hemodialysis. N Engl J Med. 1985 Feb 21; 312(8):457-62.
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    Score: 0.001
  85. Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes. J Clin Invest. 1984 Oct; 74(4):1291-300.
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    Score: 0.001
  86. Deficiency of a surface membrane glycoprotein (Mo1) in man. J Clin Invest. 1984 Jan; 73(1):153-9.
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    Score: 0.001
  87. Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). J Clin Invest. 1983 Jul; 72(1):171-9.
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    Score: 0.001
  88. Role of human factor I and C3b receptor in the cleavage of surface-bound C3bi molecules. Eur J Immunol. 1983 Jun; 13(6):465-70.
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    Score: 0.001
  89. CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD. Blood. 2003 May 15; 101(10):4033-41.
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    Score: 0.001
  90. Low ionic strength or chemical cross-linking of monomeric C3b increases its binding affinity to the human complement C3b receptor. Immunology. 1983 Feb; 48(2):229-37.
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    Score: 0.001
  91. Divalent cations and the relationship between alphaA and betaA domains in integrins. Biochem Pharmacol. 2002 Sep; 64(5-6):805-12.
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    Score: 0.001
  92. Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity. J Biol Chem. 2002 Jul 12; 277(28):24959-66.
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    Score: 0.001
  93. Deficiency of a granulocyte-membrane glycoprotein (gp150) in a boy with recurrent bacterial infections. N Engl J Med. 1982 Mar 25; 306(12):693-9.
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    Score: 0.001
  94. Characterization of the human complement (c3b) receptor with a fluid phase C3b dimer. J Immunol. 1981 Oct; 127(4):1348-54.
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    Score: 0.001
  95. Alternative complement pathway-dependent ingestion of fluolite particles by human granulocytes. J Immunol. 1981 Jul; 127(1):278-81.
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    Score: 0.001
  96. Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1182-7.
    View in: PubMed
    Score: 0.001
  97. CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA. Nucleic Acids Res. 2000 Jun 01; 28(11):2256-67.
    View in: PubMed
    Score: 0.001
  98. Solubilization of C3 fragments deposited on cross-linked dextran gel beads. Clin Immunol Immunopathol. 1979 Nov; 14(3):384-94.
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    Score: 0.001
  99. Complement activation in semisolid media: insolubilization of alternative pathway convertases in agar gels with C3 nephritic factor-containing sera. J Immunol. 1977 Oct; 119(4):1316-20.
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    Score: 0.001
  100. Outside-in signaling by lipopolysaccharide through a tailless integrin. J Immunol. 1997 Jul 01; 159(1):433-8.
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    Score: 0.001
  101. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996 Dec; 5(6):653-66.
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    Score: 0.001
  102. Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure. 1995 Dec 15; 3(12):1333-40.
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    Score: 0.000
  103. Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain. J Immunol. 1995 Oct 01; 155(7):3619-28.
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    Score: 0.000
  104. Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion. J Cell Biol. 1993 Feb; 120(3):785-98.
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    Score: 0.000
  105. Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways. J Cell Biol. 1992 May; 117(4):757-64.
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    Score: 0.000
  106. Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction. J Clin Invest. 1991 Nov; 88(5):1605-12.
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    Score: 0.000
  107. Cellular myosin heavy chain in human leukocytes: isolation of 5' cDNA clones, characterization of the protein, chromosomal localization, and upregulation during myeloid differentiation. Blood. 1991 Oct 01; 78(7):1826-33.
    View in: PubMed
    Score: 0.000
  108. Antigen-specific radioimmunoassays for anti-neutrophil cytoplasmic antibodies in the diagnosis of rapidly progressive glomerulonephritis. J Am Soc Nephrol. 1991 Jul; 2(1):27-36.
    View in: PubMed
    Score: 0.000
  109. Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. J Immunol. 1989 Apr 01; 142(7):2257-63.
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    Score: 0.000
  110. Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact. J Clin Immunol. 1989 Mar; 9(2):151-8.
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    Score: 0.000
  111. Differential expression of CD11b/CD18 (Mo1) and myeloperoxidase genes during myeloid differentiation. Blood. 1989 Jan; 73(1):131-6.
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    Score: 0.000
  112. Modulation of surface CD11/CD18 glycoproteins (Mo1, LFA-1, p150,95) by human mononuclear phagocytes. Clin Immunol Immunopathol. 1988 Feb; 46(2):272-83.
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    Score: 0.000
  113. LFA-1 beta-chain synthesis and degradation in patients with leukocyte-adhesive proteins deficiency. Eur J Immunol. 1987 Mar; 17(3):417-9.
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    Score: 0.000
  114. p150/95, Third member of the LFA-1/CR3 polypeptide family identified by anti-Leu M5 monoclonal antibody. Eur J Immunol. 1985 Jul; 15(7):713-8.
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    Score: 0.000
  115. Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion. J Clin Invest. 1984 Oct; 74(4):1280-90.
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    Score: 0.000
  116. Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of high molecular weight surface glycoproteins (GP138): common relationship to diminished cell adherence. J Clin Invest. 1984 Aug; 74(2):536-51.
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    Score: 0.000
  117. Induction of granulocyte histaminase release by particle-bound complement C3 cleavage products (C3b, C3bi) and IgG. J Immunol. 1983 Jul; 131(1):439-44.
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    Score: 0.000
  118. Complement (C3b) interaction with the human granulocyte receptor: correlation of binding of fluid-phase radiolabeled ligand with histaminase release. J Immunol. 1982 May; 128(5):2313-8.
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    Score: 0.000
  119. Complement-dependent histaminase release from human granulocytes. J Clin Invest. 1979 Jun; 63(6):1195-202.
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    Score: 0.000
  120. Transfer of C3 nephritic factor from mother to fetus. Is C3 nephritic factor IgG? N Engl J Med. 1977 Jul 21; 297(3):144-5.
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    Score: 0.000
  121. Hereditary xanthinuria: report on three patients and short review of the literature. Nephron. 1977; 19(6):328-32.
    View in: PubMed
    Score: 0.000
Connection Strength

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.